DE69306570T2 - Verfahren zur herstellung von ribonukleotid-reduktasehemmern - Google Patents

Verfahren zur herstellung von ribonukleotid-reduktasehemmern

Info

Publication number
DE69306570T2
DE69306570T2 DE69306570T DE69306570T DE69306570T2 DE 69306570 T2 DE69306570 T2 DE 69306570T2 DE 69306570 T DE69306570 T DE 69306570T DE 69306570 T DE69306570 T DE 69306570T DE 69306570 T2 DE69306570 T2 DE 69306570T2
Authority
DE
Germany
Prior art keywords
reductase inhibitors
ribonucleotide reductase
producing
producing ribonucleotide
oxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69306570T
Other languages
English (en)
Other versions
DE69306570D1 (de
Inventor
James Mccarthy
Donald Matthews
Jeffrey Sabol
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Publication of DE69306570D1 publication Critical patent/DE69306570D1/de
Application granted granted Critical
Publication of DE69306570T2 publication Critical patent/DE69306570T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
DE69306570T 1992-05-12 1993-04-01 Verfahren zur herstellung von ribonukleotid-reduktasehemmern Expired - Fee Related DE69306570T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88197892A 1992-05-12 1992-05-12
US3101293A 1993-03-26 1993-03-26
PCT/US1993/003023 WO1993023414A1 (en) 1992-05-12 1993-04-01 A process for the preparation of ribonucleotide reductase inhibitors

Publications (2)

Publication Number Publication Date
DE69306570D1 DE69306570D1 (de) 1997-01-23
DE69306570T2 true DE69306570T2 (de) 1997-04-10

Family

ID=26706717

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69306570T Expired - Fee Related DE69306570T2 (de) 1992-05-12 1993-04-01 Verfahren zur herstellung von ribonukleotid-reduktasehemmern

Country Status (15)

Country Link
EP (1) EP0640092B1 (de)
JP (1) JP3265548B2 (de)
KR (1) KR100255258B1 (de)
AT (1) ATE146183T1 (de)
AU (1) AU662630B2 (de)
CA (1) CA2133961C (de)
DE (1) DE69306570T2 (de)
DK (1) DK0640092T3 (de)
ES (1) ES2098032T3 (de)
FI (1) FI106127B (de)
GR (1) GR3022400T3 (de)
HU (1) HU217963B (de)
NO (1) NO302524B1 (de)
NZ (1) NZ251886A (de)
WO (1) WO1993023414A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69421721T2 (de) * 1994-01-07 2000-04-27 Merrell Pharma Inc (e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydrat
AU2768295A (en) * 1994-07-11 1996-02-09 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
WO2003068162A2 (en) * 2002-02-14 2003-08-21 Pharmasset Ltd. Modified fluorinated nucleoside analogues
CN102435068B (zh) * 2011-09-01 2013-12-25 安徽海螺建材设计研究院 一种水泥熟料烧成系统
SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU204843B (en) * 1988-09-27 1992-02-28 Merrell Dow Pharma Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
ZA898567B (en) * 1988-11-15 1990-08-29 Merrell Dow Pharma Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives

Also Published As

Publication number Publication date
FI106127B (fi) 2000-11-30
NO302524B1 (no) 1998-03-16
NZ251886A (en) 1996-02-27
ATE146183T1 (de) 1996-12-15
GR3022400T3 (en) 1997-04-30
KR950701641A (ko) 1995-04-28
KR100255258B1 (ko) 2000-05-01
HUT68903A (en) 1995-08-28
HU9403252D0 (en) 1995-02-28
CA2133961C (en) 1998-03-31
FI945290A0 (fi) 1994-11-10
EP0640092B1 (de) 1996-12-11
CA2133961A1 (en) 1993-11-25
NO944309D0 (no) 1994-11-11
FI945290A (fi) 1994-11-10
EP0640092A1 (de) 1995-03-01
JP3265548B2 (ja) 2002-03-11
JPH07507774A (ja) 1995-08-31
NO944309L (no) 1994-11-11
DK0640092T3 (da) 1996-12-30
ES2098032T3 (es) 1997-04-16
HU217963B (hu) 2000-05-28
DE69306570D1 (de) 1997-01-23
WO1993023414A1 (en) 1993-11-25
AU662630B2 (en) 1995-09-07
AU4024793A (en) 1993-12-13

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee