NO302524B1 - Fremgangsmåte for fremstilling av ribonukleotidreduktaseinhibitorer - Google Patents

Fremgangsmåte for fremstilling av ribonukleotidreduktaseinhibitorer

Info

Publication number
NO302524B1
NO302524B1 NO944309A NO944309A NO302524B1 NO 302524 B1 NO302524 B1 NO 302524B1 NO 944309 A NO944309 A NO 944309A NO 944309 A NO944309 A NO 944309A NO 302524 B1 NO302524 B1 NO 302524B1
Authority
NO
Norway
Prior art keywords
reductase inhibitors
ribonucleotide reductase
preparation
oxy
methylene
Prior art date
Application number
NO944309A
Other languages
English (en)
Other versions
NO944309D0 (no
NO944309L (no
Inventor
James Ray Mccarthy
Donald Paul Matthews
Jeffrey Stephen Sabol
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of NO944309D0 publication Critical patent/NO944309D0/no
Publication of NO944309L publication Critical patent/NO944309L/no
Publication of NO302524B1 publication Critical patent/NO302524B1/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
NO944309A 1992-05-12 1994-11-11 Fremgangsmåte for fremstilling av ribonukleotidreduktaseinhibitorer NO302524B1 (no)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88197892A 1992-05-12 1992-05-12
US3101293A 1993-03-26 1993-03-26
PCT/US1993/003023 WO1993023414A1 (en) 1992-05-12 1993-04-01 A process for the preparation of ribonucleotide reductase inhibitors

Publications (3)

Publication Number Publication Date
NO944309D0 NO944309D0 (no) 1994-11-11
NO944309L NO944309L (no) 1994-11-11
NO302524B1 true NO302524B1 (no) 1998-03-16

Family

ID=26706717

Family Applications (1)

Application Number Title Priority Date Filing Date
NO944309A NO302524B1 (no) 1992-05-12 1994-11-11 Fremgangsmåte for fremstilling av ribonukleotidreduktaseinhibitorer

Country Status (15)

Country Link
EP (1) EP0640092B1 (no)
JP (1) JP3265548B2 (no)
KR (1) KR100255258B1 (no)
AT (1) ATE146183T1 (no)
AU (1) AU662630B2 (no)
CA (1) CA2133961C (no)
DE (1) DE69306570T2 (no)
DK (1) DK0640092T3 (no)
ES (1) ES2098032T3 (no)
FI (1) FI106127B (no)
GR (1) GR3022400T3 (no)
HU (1) HU217963B (no)
NO (1) NO302524B1 (no)
NZ (1) NZ251886A (no)
WO (1) WO1993023414A1 (no)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2179987C (en) * 1994-01-07 1999-01-19 Richard E. Donaldson Monohydrate of (e)-2'-deoxy-2'-(fluoromethylene)cytidine
AU2768295A (en) * 1994-07-11 1996-02-09 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
AU2003217402A1 (en) * 2002-02-14 2003-09-04 Pharmasset Inc Modified fluorinated nucleoside analogues
CN102435068B (zh) * 2011-09-01 2013-12-25 安徽海螺建材设计研究院 一种水泥熟料烧成系统
LT2794627T (lt) 2011-12-22 2019-01-10 Alios Biopharma, Inc. Pakeistieji nukleozidai, nukleotidai ir jų analogai
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU204843B (en) * 1988-09-27 1992-02-28 Merrell Dow Pharma Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
ZA898567B (en) * 1988-11-15 1990-08-29 Merrell Dow Pharma Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives

Also Published As

Publication number Publication date
HUT68903A (en) 1995-08-28
DE69306570T2 (de) 1997-04-10
ATE146183T1 (de) 1996-12-15
KR950701641A (ko) 1995-04-28
CA2133961C (en) 1998-03-31
JP3265548B2 (ja) 2002-03-11
HU217963B (hu) 2000-05-28
KR100255258B1 (ko) 2000-05-01
NO944309D0 (no) 1994-11-11
FI106127B (fi) 2000-11-30
ES2098032T3 (es) 1997-04-16
NO944309L (no) 1994-11-11
FI945290A0 (fi) 1994-11-10
WO1993023414A1 (en) 1993-11-25
AU662630B2 (en) 1995-09-07
CA2133961A1 (en) 1993-11-25
FI945290A (fi) 1994-11-10
DK0640092T3 (da) 1996-12-30
DE69306570D1 (de) 1997-01-23
HU9403252D0 (en) 1995-02-28
EP0640092A1 (en) 1995-03-01
AU4024793A (en) 1993-12-13
EP0640092B1 (en) 1996-12-11
JPH07507774A (ja) 1995-08-31
GR3022400T3 (en) 1997-04-30
NZ251886A (en) 1996-02-27

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