ATE135352T1 - 3-keto-hmg-coa reduktase-inhibitoren - Google Patents

3-keto-hmg-coa reduktase-inhibitoren

Info

Publication number
ATE135352T1
ATE135352T1 AT90306236T AT90306236T ATE135352T1 AT E135352 T1 ATE135352 T1 AT E135352T1 AT 90306236 T AT90306236 T AT 90306236T AT 90306236 T AT90306236 T AT 90306236T AT E135352 T1 ATE135352 T1 AT E135352T1
Authority
AT
Austria
Prior art keywords
hmg
coa reductase
keto
reductase inhibitors
inhibitors
Prior art date
Application number
AT90306236T
Other languages
English (en)
Inventor
Henry Joshua
Kenneth E Wilson
Michael S Schwartz
Ta Jyh Lee
Gerald E Stokker
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/363,792 external-priority patent/US4968693A/en
Priority claimed from US07/473,784 external-priority patent/US5001241A/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE135352T1 publication Critical patent/ATE135352T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D309/00Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30Oxygen atoms, e.g. delta-lactones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40Unsaturated compounds
    • C07C59/76Unsaturated compounds containing keto groups
    • C07C59/90Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02Silicon compounds
    • C07F7/08Compounds having one or more C—Si linkages
    • C07F7/18Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804Compounds having Si-O-C linkages
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02Oxygen as only ring hetero atoms
    • C12P17/06Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/62Carboxylic acid esters

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT90306236T 1989-06-09 1990-06-08 3-keto-hmg-coa reduktase-inhibitoren ATE135352T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/363,792 US4968693A (en) 1988-03-02 1989-06-09 3-keto HMG-COA reductase inhibitors
US07/473,784 US5001241A (en) 1989-06-09 1990-02-02 3-KETO HMG-CoA reductase inhibitors

Publications (1)

Publication Number Publication Date
ATE135352T1 true ATE135352T1 (de) 1996-03-15

Family

ID=27002201

Family Applications (1)

Application Number Title Priority Date Filing Date
AT90306236T ATE135352T1 (de) 1989-06-09 1990-06-08 3-keto-hmg-coa reduktase-inhibitoren

Country Status (3)

Country Link
EP (1) EP0409399B1 (de)
AT (1) ATE135352T1 (de)
DE (1) DE69025817T2 (de)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019076269A1 (zh) 2017-10-16 2019-04-25 清华大学 甲羟戊酸通路抑制剂及其药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5815968A (ja) * 1981-07-21 1983-01-29 Sankyo Co Ltd Ml−236b誘導体およびその製法
JPS5835144A (ja) * 1981-08-27 1983-03-01 Sankyo Co Ltd Mb−530b誘導体およびその製造法
JPS5855443A (ja) * 1981-09-25 1983-04-01 Sankyo Co Ltd オクタヒドロナフタリン誘導体およびその製造法

Also Published As

Publication number Publication date
DE69025817D1 (de) 1996-04-18
EP0409399B1 (de) 1996-03-13
EP0409399A1 (de) 1991-01-23
DE69025817T2 (de) 1996-11-14

Similar Documents

Publication Publication Date Title
ATE196761T1 (de) Inhibitoren retroviraler proteasen
ES2101960T3 (es) Lactamas benzo-condensadas.
IT1237793B (it) Composti attivi come inibitori dell'enzima hmg-coa reduttasi
DK354189D0 (da) Fremgangsmaade til lactonisering af mevinsyreforbindelser
NO914092D0 (no) Fremgangsmaate for fremstilling av mercaptoacetylamidderivater
FI906045A0 (fi) Kvaevehaltiga spirocykliska foereningar.
NO931795D0 (no) Dobbeltvirkende inhibitorer
ES2088076T3 (es) Piperacinil- y piperidinilciclohexanoles.
ATE126509T1 (de) Disäuren von diarylstyrylchinolin.
ATE263771T1 (de) Totalsynthese von acylfulvenen mit antitumorwirkung
ATE209199T1 (de) Chinolin und chinazolin derivate zur behandlung von arthritis
DK51087A (da) Antihypercholesterolaemiske forbindelser
DK0791007T3 (da) Antifungale sordaridinderivater
DE3772015D1 (de) Chinolinverbindung.
ES2179254T3 (es) 1-poliarilpirazoles plaguicidas.
ES2087247T3 (es) Inhibidor de aldosa reductasa.
DE69007695D1 (de) Fucosidase-Inhibitoren.
IT1237792B (it) Composti attivi come inibitori dell'enzima hmg-coa reduttasi
ATE135352T1 (de) 3-keto-hmg-coa reduktase-inhibitoren
NO904335D0 (no) Fenylsulfon-derivater.
FI911124A (fi) Nya pyridinderivat och foerfaranden foer deras syntetisering.
DE3869282D1 (de) Inhibitoren von hmg-coa-reduktase.
DK656889D0 (da) Hidtil ukendte forbindelser
ITMI921854A0 (it) Composti attivi come inibitori dell'enzima hmg-coa reduttasi

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties