NO931694L - Nye 4-arylpiperaciner og 4-arylpiperidiner - Google Patents
Nye 4-arylpiperaciner og 4-arylpiperidinerInfo
- Publication number
- NO931694L NO931694L NO93931694A NO931694A NO931694L NO 931694 L NO931694 L NO 931694L NO 93931694 A NO93931694 A NO 93931694A NO 931694 A NO931694 A NO 931694A NO 931694 L NO931694 L NO 931694L
- Authority
- NO
- Norway
- Prior art keywords
- arylpiperacines
- arylpiperidines
- new
- compounds
- disclosed
- Prior art date
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Classifications
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
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- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
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- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/62—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to atoms of the carbocyclic ring
- C07D317/66—Nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Otolaryngology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75788191A | 1991-09-11 | 1991-09-11 | |
PCT/US1992/007754 WO1993004682A1 (en) | 1991-09-11 | 1992-09-11 | Novel 4-arylpiperazines and 4-arylpiperidines |
Publications (3)
Publication Number | Publication Date |
---|---|
NO931694D0 NO931694D0 (no) | 1993-05-10 |
NO931694L true NO931694L (no) | 1993-06-30 |
NO303780B1 NO303780B1 (no) | 1998-08-31 |
Family
ID=25049613
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO93931695A NO931695L (no) | 1991-09-11 | 1993-05-10 | Nye 4-arylpiperaciner og 4-arylpiperidiner |
NO931694A NO303780B1 (no) | 1991-09-11 | 1993-05-10 | Nye 4-arylpiperaziner og 4-arylpiperidiner, sammensetning inneholdende dem samt deres anvendelse til fremstilling av terapeutikum |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO93931695A NO931695L (no) | 1991-09-11 | 1993-05-10 | Nye 4-arylpiperaciner og 4-arylpiperidiner |
Country Status (21)
Country | Link |
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EP (2) | EP0562049A4 (no) |
JP (2) | JPH06502183A (no) |
KR (1) | KR100196249B1 (no) |
AT (1) | ATE219938T1 (no) |
AU (2) | AU1363392A (no) |
CA (2) | CA2095826A1 (no) |
DE (1) | DE69232665T2 (no) |
DK (1) | DK0563345T3 (no) |
ES (1) | ES2179822T3 (no) |
FI (2) | FI111639B (no) |
HU (2) | HU217068B (no) |
IE (1) | IE914218A1 (no) |
MX (1) | MX9102407A (no) |
NO (2) | NO931695L (no) |
NZ (1) | NZ240863A (no) |
PT (1) | PT99700A (no) |
RU (1) | RU2139867C1 (no) |
SG (1) | SG70980A1 (no) |
TW (1) | TW209867B (no) |
WO (2) | WO1993004684A1 (no) |
ZA (1) | ZA919629B (no) |
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US5807858A (en) * | 1996-06-05 | 1998-09-15 | Delta Pharmaceutical, Inc. | Compositions and methods for reducing respiratory depression |
US5985880A (en) | 1996-06-05 | 1999-11-16 | Delta Pharmaceuticals | Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds |
US5681830A (en) * | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
US5332743A (en) * | 1992-06-12 | 1994-07-26 | Mcneilab, Inc. | Benzyl and benzhydryl alcohols |
US5314885A (en) * | 1992-09-11 | 1994-05-24 | Mcneilab, Inc. | Cyclic benzylamino, benzylamido, and benzylimido antipsychotic agents |
MY111348A (en) * | 1993-07-30 | 1999-11-30 | Ardent Pharmaceuticals Inc | Opioid diarylmethylpiperazines and piperidines |
IL112099A (en) * | 1993-12-23 | 1999-07-14 | Ortho Pharma Corp | N-oxides of 4-arylpiperazines and 4-arylpiperidines and pharmaceutical compositions containing them |
US6225312B1 (en) * | 1996-03-29 | 2001-05-01 | Duphar International Research B.V. | Piperazine and piperidine compounds |
US5859246A (en) | 1997-01-30 | 1999-01-12 | Neurogen Corporation | 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands |
TW530054B (en) * | 1997-09-24 | 2003-05-01 | Duphar Int Res | New piperazine and piperidine compounds |
EP0982304B1 (en) * | 1998-06-30 | 2002-10-02 | Eli Lilly And Company | Piperidine derivatives having effects on serotonin related systems |
GB2352240A (en) * | 1999-07-13 | 2001-01-24 | Lilly Co Eli | Novel sulphonamides useful in treating CNS disorders |
SE9904723D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission II |
SE9904724D0 (sv) | 1999-12-22 | 1999-12-22 | Carlsson A Research Ab | New modulators of dopamine neurotransmission I |
USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
US6727264B1 (en) | 2001-07-05 | 2004-04-27 | Synaptic Pharmaceutical Corporation | Substituted anilinic piperidines as MCH selective antagonists |
WO2004029048A1 (en) * | 2002-09-26 | 2004-04-08 | Warner-Lambert Company Llc | Heterocyclic substituted piperazines for the treatment of schizophrenia |
AU2003272030A1 (en) * | 2002-11-08 | 2004-06-07 | Warner-Lambert Company Llc | Phenylalkyl and pyridylalkyl piperazine derivatives |
US7160888B2 (en) | 2003-08-22 | 2007-01-09 | Warner Lambert Company Llc | [1,8]naphthyridin-2-ones and related compounds for the treatment of schizophrenia |
US7851629B2 (en) | 2004-06-08 | 2010-12-14 | Nsab, Filial Af Neurosearch Sweden Ab, Sverige | Disubstituted phenylpiperidines as modulators of dopamine and serotonin neurotransmission |
MXPA06013944A (es) | 2004-06-08 | 2007-10-08 | Neurosearch Sweden Ab | Nuevas fenilpiperidinas/piperazinas disustituidas como moduladores de la neurotransmision de dopamina. |
SE0401465D0 (sv) | 2004-06-08 | 2004-06-08 | Carlsson A Research Ab | New substituted piperdines as modulators of dopamine neurotransmission |
PL1802573T3 (pl) | 2004-10-13 | 2017-03-31 | Teva Pharmaceuticals International Gmbh | Proces syntezy 4-(3-metanosulfonylofenylo)-1-N-propylopiperydyny |
JP5118975B2 (ja) | 2004-12-24 | 2013-01-16 | アストラゼネカ・アクチエボラーグ | Ccr2bアンタゴニストとしてのヘテロ環式化合物 |
RS51311B (sr) | 2005-09-16 | 2010-12-31 | Janssen Pharmaceutica N.V. | Ciklopropil amini kao modulatori histaminskog h3 receptora |
SE529246C2 (sv) | 2005-10-13 | 2007-06-12 | Neurosearch Sweden Ab | Nya disubstituerade fenyl-piperidiner som modulatorer för dopaminneurotransmission |
GB0525957D0 (en) | 2005-12-21 | 2006-02-01 | Astrazeneca Ab | Methods |
US20080221116A1 (en) * | 2006-09-15 | 2008-09-11 | Baxter Ellen W | ISOXAZOLINE ALPHA 1a/1d ADRENORECEPTOR ANTAGONISTS |
AR068509A1 (es) * | 2007-09-19 | 2009-11-18 | Jerini Ag | Antagosnistas del receptor de bradiquinina b1 |
NZ597107A (en) | 2009-06-25 | 2013-12-20 | Alkermes Pharma Ireland Ltd | Heterocyclic compounds for the treatment of neurological and psychological disorders |
US8697911B2 (en) | 2010-07-07 | 2014-04-15 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
US9079880B2 (en) | 2010-07-07 | 2015-07-14 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
WO2012027495A1 (en) | 2010-08-27 | 2012-03-01 | University Of The Pacific | Piperazinylpyrimidine analogues as protein kinase inhibitors |
US9000154B2 (en) | 2010-10-19 | 2015-04-07 | Boehringer Ingelheim International Gmbh | Rho kinase inhibitors |
CN103130737B (zh) * | 2011-12-05 | 2015-12-02 | 江苏恒谊药业有限公司 | 环己烷胺类化合物及其作为抗精神分裂症药物的应用 |
TWI579272B (zh) | 2011-12-08 | 2017-04-21 | 梯瓦製藥國際有限責任公司 | 普多比啶(pridopidine)之氫溴酸鹽 |
BR112014024672A8 (pt) | 2012-04-04 | 2018-04-03 | Ivax Int Gmbh | Composições farmacêuticas para terapia de combinação |
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US3988371A (en) * | 1972-03-09 | 1976-10-26 | Hansl Nikolaus R | Meta-[2-(benzylamino)-ethyl] benzoic acid amides |
DE2926472A1 (de) * | 1979-06-30 | 1981-01-15 | Thomae Gmbh Dr K | Neue benzoylderivate, deren herstellung und deren verwendung als arzneimittel |
ZA825719B (en) * | 1981-09-03 | 1983-06-29 | Recordati Chem Pharm | Alkanoylanilides |
US4666924A (en) * | 1982-07-26 | 1987-05-19 | E. I. Du Pont De Nemours & Co. | Certain pyridyl substituted aminomethyl benzene derivatives having anti-arrhythmic activity |
DE3571436D1 (en) * | 1984-12-21 | 1989-08-17 | Duphar Int Res | New pharmaceutical compositions having anti-psychotic properties |
GB8603120D0 (en) * | 1986-02-07 | 1986-03-12 | Pfizer Ltd | Anti-dysrhythmia agents |
CA1279645C (en) * | 1986-02-27 | 1991-01-29 | Ineke Van Wijngaarden | Aryl-substituted (n-piperidinyl)methyl- and (n-piperazinyl)methylazoles having antipsychotic properties |
JPS62246560A (ja) * | 1986-04-18 | 1987-10-27 | Kanebo Ltd | 新規なビペラジン誘導体および該化合物を有効成分とする抗潰瘍薬 |
EP0288575A4 (en) * | 1986-10-27 | 1990-10-10 | Yoshitomi Pharmaceutical Industries, Ltd. | Piperazine compounds and their medicinal use |
US4782062A (en) * | 1987-05-11 | 1988-11-01 | Merck & Co., Inc. | 9-(2-hydroxymethyl)cycloalkylmethyl) guanines |
US4992441A (en) * | 1987-10-14 | 1991-02-12 | Mcneilab, Inc. | 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia |
GB8909209D0 (en) * | 1989-04-22 | 1989-06-07 | Wyeth John & Brother Ltd | Piperazine derivatives |
DK0395312T3 (da) * | 1989-04-22 | 1999-06-23 | Wyeth John & Brother Ltd | Piperazinderivater |
PT93824B (pt) * | 1989-04-22 | 1996-09-30 | Wyeth John & Brother Ltd | Processo para a preparacao de derivados de piperazina |
DK0402644T3 (da) * | 1989-05-19 | 1996-01-02 | Hoechst Roussel Pharma | N-(Aryloxyalkyl)-heteroarylpiperidiner og -heteroarylpiperaziner, fremgangsmåde til deres fremstilli ng samt deres anvendelse som medikamenter |
FR2671350A1 (fr) * | 1991-01-08 | 1992-07-10 | Adir | Nouveaux derives de benzisoxazole et de benzisothiazole, leur procede de preparation, et les compositions pharmaceutiques les renfermant. |
FR2670491B1 (fr) * | 1990-12-14 | 1993-02-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les renfermant. |
-
1991
- 1991-12-04 NZ NZ240863A patent/NZ240863A/en not_active IP Right Cessation
- 1991-12-04 IE IE421891A patent/IE914218A1/en not_active Application Discontinuation
- 1991-12-05 MX MX9102407A patent/MX9102407A/es not_active IP Right Cessation
- 1991-12-05 PT PT99700A patent/PT99700A/pt not_active Application Discontinuation
- 1991-12-05 ZA ZA919629A patent/ZA919629B/xx unknown
- 1991-12-20 JP JP4506154A patent/JPH06502183A/ja active Pending
- 1991-12-20 WO PCT/US1991/009082 patent/WO1993004684A1/en not_active Application Discontinuation
- 1991-12-20 HU HU9301362A patent/HU217068B/hu unknown
- 1991-12-20 CA CA002095826A patent/CA2095826A1/en not_active Abandoned
- 1991-12-20 AU AU13633/92A patent/AU1363392A/en not_active Withdrawn
- 1991-12-20 EP EP9292906123A patent/EP0562049A4/en not_active Withdrawn
-
1992
- 1992-01-30 TW TW081100689A patent/TW209867B/zh active
- 1992-09-11 AU AU26599/92A patent/AU657799B2/en not_active Ceased
- 1992-09-11 DK DK92920313T patent/DK0563345T3/da active
- 1992-09-11 EP EP92920313A patent/EP0563345B1/en not_active Expired - Lifetime
- 1992-09-11 HU HU9301361A patent/HUT64535A/hu unknown
- 1992-09-11 RU RU93041055A patent/RU2139867C1/ru not_active IP Right Cessation
- 1992-09-11 DE DE69232665T patent/DE69232665T2/de not_active Expired - Fee Related
- 1992-09-11 KR KR1019930701410A patent/KR100196249B1/ko not_active IP Right Cessation
- 1992-09-11 AT AT92920313T patent/ATE219938T1/de not_active IP Right Cessation
- 1992-09-11 WO PCT/US1992/007754 patent/WO1993004682A1/en active IP Right Grant
- 1992-09-11 JP JP5505525A patent/JP2941945B2/ja not_active Expired - Fee Related
- 1992-09-11 ES ES92920313T patent/ES2179822T3/es not_active Expired - Lifetime
- 1992-09-11 CA CA002095847A patent/CA2095847A1/en not_active Abandoned
- 1992-09-11 SG SG1996005506A patent/SG70980A1/en unknown
-
1993
- 1993-05-10 FI FI932104A patent/FI111639B/fi active
- 1993-05-10 NO NO93931695A patent/NO931695L/no unknown
- 1993-05-10 NO NO931694A patent/NO303780B1/no unknown
- 1993-05-10 FI FI932103A patent/FI932103A0/fi unknown
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