FI945290A - Menetelmä ribonukleotidireduktaasi-inhibiittoreiden valmistamista varten - Google Patents

Menetelmä ribonukleotidireduktaasi-inhibiittoreiden valmistamista varten Download PDF

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Publication number
FI945290A
FI945290A FI945290A FI945290A FI945290A FI 945290 A FI945290 A FI 945290A FI 945290 A FI945290 A FI 945290A FI 945290 A FI945290 A FI 945290A FI 945290 A FI945290 A FI 945290A
Authority
FI
Finland
Prior art keywords
reductase inhibitors
ribonucleotide reductase
preparing
oxy
methylene
Prior art date
Application number
FI945290A
Other languages
English (en)
Swedish (sv)
Other versions
FI106127B (fi
FI945290A0 (fi
Inventor
James Ray Mccarthy
Donald Paul Matthews
Jeffrey Stephen Sabol
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of FI945290A0 publication Critical patent/FI945290A0/fi
Publication of FI945290A publication Critical patent/FI945290A/fi
Application granted granted Critical
Publication of FI106127B publication Critical patent/FI106127B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
FI945290A 1992-05-12 1994-11-10 Menetelmiä ribonukleotidireduktaasi-inhibiittoreiden valmistamiseksi ja uusia välituotteita FI106127B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US88197892A 1992-05-12 1992-05-12
US88197892 1992-05-12
US3101293A 1993-03-26 1993-03-26
US3101293 1993-03-26
PCT/US1993/003023 WO1993023414A1 (en) 1992-05-12 1993-04-01 A process for the preparation of ribonucleotide reductase inhibitors
US9303023 1993-04-01

Publications (3)

Publication Number Publication Date
FI945290A0 FI945290A0 (fi) 1994-11-10
FI945290A true FI945290A (fi) 1994-11-10
FI106127B FI106127B (fi) 2000-11-30

Family

ID=26706717

Family Applications (1)

Application Number Title Priority Date Filing Date
FI945290A FI106127B (fi) 1992-05-12 1994-11-10 Menetelmiä ribonukleotidireduktaasi-inhibiittoreiden valmistamiseksi ja uusia välituotteita

Country Status (15)

Country Link
EP (1) EP0640092B1 (fi)
JP (1) JP3265548B2 (fi)
KR (1) KR100255258B1 (fi)
AT (1) ATE146183T1 (fi)
AU (1) AU662630B2 (fi)
CA (1) CA2133961C (fi)
DE (1) DE69306570T2 (fi)
DK (1) DK0640092T3 (fi)
ES (1) ES2098032T3 (fi)
FI (1) FI106127B (fi)
GR (1) GR3022400T3 (fi)
HU (1) HU217963B (fi)
NO (1) NO302524B1 (fi)
NZ (1) NZ251886A (fi)
WO (1) WO1993023414A1 (fi)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69421721T2 (de) * 1994-01-07 2000-04-27 Merrell Pharma Inc (e)-2'-deoxy-2'-(fluormethylen)cytidin-monohydrat
AU2768295A (en) * 1994-07-11 1996-02-09 Hoechst Marion Roussel, Inc. Method of treating a neoplastic disease state by conjunctive therapy with 2'-fluoromethylidene derivatives and radiation or chemotherapy
WO2003068162A2 (en) * 2002-02-14 2003-08-21 Pharmasset Ltd. Modified fluorinated nucleoside analogues
CN102435068B (zh) * 2011-09-01 2013-12-25 安徽海螺建材设计研究院 一种水泥熟料烧成系统
SG10201610936RA (en) 2011-12-22 2017-02-27 Alios Biopharma Inc Substituted nucleosides, nucleotides and analogs thereof
US9441007B2 (en) 2012-03-21 2016-09-13 Alios Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof
USRE48171E1 (en) 2012-03-21 2020-08-25 Janssen Biopharma, Inc. Substituted nucleosides, nucleotides and analogs thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU204843B (en) * 1988-09-27 1992-02-28 Merrell Dow Pharma Process for producing 2'-halogen-methylidene adenosine derivatives and pharmaceutical compositions comprising same
ZA898567B (en) * 1988-11-15 1990-08-29 Merrell Dow Pharma Novel 2'-halomethylidene,2'-ethenylidene and 2'-ethynyl cytidine,uridine and guanosine derivatives

Also Published As

Publication number Publication date
FI106127B (fi) 2000-11-30
NO302524B1 (no) 1998-03-16
NZ251886A (en) 1996-02-27
ATE146183T1 (de) 1996-12-15
GR3022400T3 (en) 1997-04-30
KR950701641A (ko) 1995-04-28
KR100255258B1 (ko) 2000-05-01
HUT68903A (en) 1995-08-28
HU9403252D0 (en) 1995-02-28
CA2133961C (en) 1998-03-31
FI945290A0 (fi) 1994-11-10
EP0640092B1 (en) 1996-12-11
CA2133961A1 (en) 1993-11-25
NO944309D0 (no) 1994-11-11
EP0640092A1 (en) 1995-03-01
JP3265548B2 (ja) 2002-03-11
JPH07507774A (ja) 1995-08-31
NO944309L (no) 1994-11-11
DK0640092T3 (da) 1996-12-30
ES2098032T3 (es) 1997-04-16
HU217963B (hu) 2000-05-28
DE69306570D1 (de) 1997-01-23
WO1993023414A1 (en) 1993-11-25
AU662630B2 (en) 1995-09-07
AU4024793A (en) 1993-12-13
DE69306570T2 (de) 1997-04-10

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Legal Events

Date Code Title Description
PC Transfer of assignment of patent

Owner name: AVENTIS INC.

Free format text: AVENTIS INC.

MA Patent expired