KR101353829B1 - Ｐｉ-3 키나제 억제제로서 사용되는 피리미딘 유도체 - Google Patents

Ｐｉ-3 키나제 억제제로서 사용되는 피리미딘 유도체 Download PDF

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KR101353829B1
KR101353829B1 KR1020087020198A KR20087020198A KR101353829B1 KR 101353829 B1 KR101353829 B1 KR 101353829B1 KR 1020087020198 A KR1020087020198 A KR 1020087020198A KR 20087020198 A KR20087020198 A KR 20087020198A KR 101353829 B1 KR101353829 B1 KR 101353829B1
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South Korea
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substituted
unsubstituted
amine
compound
pyridin
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KR20080096776A (ko
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매튜 버거
지-지에 니
사비나 페키
고다나 아탈라
사라 바툴리스
켈리 프레지어
아론 스미스
조엘 버하겐
얀첸 장
앨런 웨그먼
사이먼 엔지
키스 피스터
대니얼 푼
알리시아 루이
테레사 피크
폴 바산티
에드윈 이바노비치
웬디 팬틀
토마스 헨드릭슨
마크 냅
한 메리트
찰스 볼리바
매리언 위즈먼
시아후아 신
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노파르티스 아게
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020087020198A 2006-01-20 2007-01-22 Ｐｉ-3 키나제 억제제로서 사용되는 피리미딘 유도체 Expired - Fee Related KR101353829B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US76078906P 2006-01-20 2006-01-20
US60/760,789 2006-01-20
PCT/US2007/001708 WO2007084786A1 (en) 2006-01-20 2007-01-22 Pyrimidine derivatives used as pi-3 kinase inhibitors

Publications (2)

Publication Number Publication Date
KR20080096776A KR20080096776A (ko) 2008-11-03
KR101353829B1 true KR101353829B1 (ko) 2014-01-21

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KR1020087020198A Expired - Fee Related KR101353829B1 (ko) 2006-01-20 2007-01-22 Ｐｉ-3 키나제 억제제로서 사용되는 피리미딘 유도체

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US (2) US8217035B2 (enExample)
EP (2) EP1984350B1 (enExample)
JP (1) JP5161110B2 (enExample)
KR (1) KR101353829B1 (enExample)
CN (1) CN101389622B (enExample)
AR (2) AR059087A1 (enExample)
AT (1) ATE478064T1 (enExample)
AU (1) AU2007206048B2 (enExample)
BR (1) BRPI0707189B1 (enExample)
CA (1) CA2636993C (enExample)
CR (1) CR10163A (enExample)
CY (1) CY1111091T1 (enExample)
DE (1) DE602007008529D1 (enExample)
DK (2) DK1984350T3 (enExample)
EA (1) EA018083B1 (enExample)
EC (1) ECSP088630A (enExample)
ES (2) ES2351172T3 (enExample)
GE (1) GEP20115147B (enExample)
GT (1) GT200800143A (enExample)
HN (1) HN2008001144A (enExample)
HR (2) HRP20100603T1 (enExample)
IL (1) IL192763A (enExample)
JO (1) JO2660B1 (enExample)
MA (1) MA30208B1 (enExample)
ME (2) ME00012B (enExample)
MY (1) MY144233A (enExample)
NO (1) NO342183B1 (enExample)
NZ (1) NZ569771A (enExample)
PE (1) PE20071322A1 (enExample)
PL (2) PL1984350T3 (enExample)
PT (2) PT1984350E (enExample)
RS (2) RS51548B (enExample)
SI (2) SI1984350T1 (enExample)
SM (1) SMP200800048B (enExample)
SV (1) SV2008002984A (enExample)
TN (1) TNSN08305A1 (enExample)
TW (2) TWI385170B (enExample)
UA (1) UA96284C2 (enExample)
WO (1) WO2007084786A1 (enExample)
ZA (1) ZA200806017B (enExample)

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