JP7275111B2 - 脂質ナノ粒子の生成方法 - Google Patents

脂質ナノ粒子の生成方法 Download PDF

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Publication number
JP7275111B2
JP7275111B2 JP2020512372A JP2020512372A JP7275111B2 JP 7275111 B2 JP7275111 B2 JP 7275111B2 JP 2020512372 A JP2020512372 A JP 2020512372A JP 2020512372 A JP2020512372 A JP 2020512372A JP 7275111 B2 JP7275111 B2 JP 7275111B2
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lipid
mir
optionally substituted
peg
glycero
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Japanese (ja)
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JP2020532528A (ja
JP2020532528A5 (enExample
Inventor
シャリター、ジョセフ
ハセット、キンバリー
スミス、マイク
アルマーソン、オルン
ブリット、ルイス
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ModernaTx Inc
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ModernaTx Inc
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Priority to JP2023076121A priority Critical patent/JP2023093756A/ja
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Publication of JP7275111B2 publication Critical patent/JP7275111B2/ja
Priority to JP2025072087A priority patent/JP2025108727A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2020512372A 2017-08-31 2018-08-31 脂質ナノ粒子の生成方法 Active JP7275111B2 (ja)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2023076121A JP2023093756A (ja) 2017-08-31 2023-05-02 脂質ナノ粒子の生成方法
JP2025072087A JP2025108727A (ja) 2017-08-31 2025-04-24 脂質ナノ粒子の生成方法

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762553088P 2017-08-31 2017-08-31
US201762553085P 2017-08-31 2017-08-31
US62/553,085 2017-08-31
US62/553,088 2017-08-31
US201762590193P 2017-11-22 2017-11-22
US62/590,193 2017-11-22
PCT/US2018/049251 WO2019046809A1 (en) 2017-08-31 2018-08-31 METHODS OF MANUFACTURING LIPID NANOPARTICLES

Related Child Applications (1)

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JP2023076121A Division JP2023093756A (ja) 2017-08-31 2023-05-02 脂質ナノ粒子の生成方法

Publications (3)

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JP2020532528A JP2020532528A (ja) 2020-11-12
JP2020532528A5 JP2020532528A5 (enExample) 2021-10-07
JP7275111B2 true JP7275111B2 (ja) 2023-05-17

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JP2020512372A Active JP7275111B2 (ja) 2017-08-31 2018-08-31 脂質ナノ粒子の生成方法
JP2023076121A Pending JP2023093756A (ja) 2017-08-31 2023-05-02 脂質ナノ粒子の生成方法
JP2025072087A Pending JP2025108727A (ja) 2017-08-31 2025-04-24 脂質ナノ粒子の生成方法

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JP2023076121A Pending JP2023093756A (ja) 2017-08-31 2023-05-02 脂質ナノ粒子の生成方法
JP2025072087A Pending JP2025108727A (ja) 2017-08-31 2025-04-24 脂質ナノ粒子の生成方法

Country Status (8)

Country Link
US (2) US11744801B2 (enExample)
EP (1) EP3675817A1 (enExample)
JP (3) JP7275111B2 (enExample)
CN (1) CN111315359A (enExample)
AU (1) AU2018326799A1 (enExample)
CA (1) CA3073211A1 (enExample)
MX (1) MX2020002348A (enExample)
WO (1) WO2019046809A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023093756A (ja) * 2017-08-31 2023-07-04 モデルナティエックス インコーポレイテッド 脂質ナノ粒子の生成方法

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