JP5836367B2 - Ａｔｒキナーゼ阻害剤として有用な化合物 - Google Patents

Ａｔｒキナーゼ阻害剤として有用な化合物 Download PDF

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Publication number
JP5836367B2
JP5836367B2 JP2013510300A JP2013510300A JP5836367B2 JP 5836367 B2 JP5836367 B2 JP 5836367B2 JP 2013510300 A JP2013510300 A JP 2013510300A JP 2013510300 A JP2013510300 A JP 2013510300A JP 5836367 B2 JP5836367 B2 JP 5836367B2
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Japan
Prior art keywords
alkyl
pharmaceutically acceptable
acceptable salt
compound
cancer
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Expired - Fee Related
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JP2013510300A
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Japanese (ja)
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JP2013526541A (ja
JP2013526541A5 (enExample
Inventor
ジャン−ダミアン シャリエ，
ジャン−ダミアン シャリエ，
ヘイリー マリー ビンチ，
ヘイリー マリー ビンチ，
デニス ジェームズ ハーレイ，
デニス ジェームズ ハーレイ，
トーマス クリーブランド，
トーマス クリーブランド，
プラモッド ジョシ，
プラモッド ジョシ，
レブ タイラー デューイ ファニング，
レブ タイラー デューイ ファニング，
ジョアン ピンダー，
ジョアン ピンダー，
マイケル オドネル，
マイケル オドネル，
アニーサ ニザラーリ ビラーニ，
アニーサ ニザラーリ ビラーニ，
ロナルド マルセレス アルフォンサス ネグテル，
ロナルド マルセレス アルフォンサス ネグテル，
スティーブン ジョン デュラント，
スティーブン ジョン デュラント，
スティーブン クリントン ヤング，
スティーブン クリントン ヤング，
ピエール−アンリ ストーク，
ピエール−アンリ ストーク，
ケイ，　デイビッド
デイビッド ケイ，
フィリップ マイケル リーパー，
フィリップ マイケル リーパー，
マシュー ポール グローテ，
マシュー ポール グローテ，
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Publication of JP2013526541A publication Critical patent/JP2013526541A/ja
Publication of JP2013526541A5 publication Critical patent/JP2013526541A5/ja
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Expired - Fee Related legal-status Critical Current
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013510300A 2010-05-12 2011-05-12 Ａｔｒキナーゼ阻害剤として有用な化合物 Expired - Fee Related JP5836367B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33386710P 2010-05-12 2010-05-12
US61/333,867 2010-05-12
US201161470585P 2011-04-01 2011-04-01
US61/470,585 2011-04-01
PCT/US2011/036246 WO2011143426A1 (en) 2010-05-12 2011-05-12 Compounds useful as inhibitors of atr kinase

Publications (3)

Publication Number Publication Date
JP2013526541A JP2013526541A (ja) 2013-06-24
JP2013526541A5 JP2013526541A5 (enExample) 2014-06-26
JP5836367B2 true JP5836367B2 (ja) 2015-12-24

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JP2013510300A Expired - Fee Related JP5836367B2 (ja) 2010-05-12 2011-05-12 Ａｔｒキナーゼ阻害剤として有用な化合物

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Country Link
US (1) US9630956B2 (enExample)
EP (1) EP2569313A1 (enExample)
JP (1) JP5836367B2 (enExample)
KR (1) KR20130066633A (enExample)
CN (1) CN103228651A (enExample)
AU (1) AU2011253025A1 (enExample)
CA (1) CA2798763A1 (enExample)
IL (1) IL222968A0 (enExample)
MX (1) MX2012013081A (enExample)
NZ (1) NZ603477A (enExample)
RU (1) RU2012153675A (enExample)
SG (1) SG185524A1 (enExample)
WO (1) WO2011143426A1 (enExample)
ZA (1) ZA201208373B (enExample)

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US9340546B2 (en) 2012-12-07 2016-05-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
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