ATE330968T1 - Cyclosporin-derivate und verfahren zu deren herstellung - Google Patents
Cyclosporin-derivate und verfahren zu deren herstellungInfo
- Publication number
- ATE330968T1 ATE330968T1 AT00901297T AT00901297T ATE330968T1 AT E330968 T1 ATE330968 T1 AT E330968T1 AT 00901297 T AT00901297 T AT 00901297T AT 00901297 T AT00901297 T AT 00901297T AT E330968 T1 ATE330968 T1 AT E330968T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- derivatives
- cyclosporine derivatives
- relates
- cyclosporine
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH22099 | 1999-02-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE330968T1 true ATE330968T1 (de) | 2006-07-15 |
Family
ID=4182021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00901297T ATE330968T1 (de) | 1999-02-05 | 2000-02-07 | Cyclosporin-derivate und verfahren zu deren herstellung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6790935B1 (de) |
| EP (1) | EP1150999B1 (de) |
| AT (1) | ATE330968T1 (de) |
| AU (1) | AU2125300A (de) |
| CY (1) | CY1105452T1 (de) |
| DE (1) | DE60028936T2 (de) |
| DK (1) | DK1150999T3 (de) |
| ES (1) | ES2267492T3 (de) |
| PT (1) | PT1150999E (de) |
| WO (1) | WO2000046239A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60208180T2 (de) * | 2001-04-20 | 2006-08-17 | Debiopharm S.A. | Modifiziertes, als medikamentvorstufe anwendbares cyclosporin und dessen verwendung |
| US8889629B2 (en) * | 2005-01-10 | 2014-11-18 | Debiopharm International Sa | Use of a cyclic undecapeptide for the preparation of a medicament for administration during myocardial ischaemic events |
| BRPI0605658B8 (pt) * | 2006-12-29 | 2021-05-25 | Embrapa Pesquisa Agropecuaria | peptídeo antibiótico rico em glicina derivado de planta |
| US8153815B2 (en) * | 2008-10-07 | 2012-04-10 | Hoffman-La Roche Inc. | Pseudoproline dipeptides |
| ES2921576T3 (es) | 2008-12-19 | 2022-08-29 | Vertex Pharma | Compuestos útiles como inhibidores de la quinasa ATR |
| US8367053B2 (en) * | 2009-07-09 | 2013-02-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8349312B2 (en) * | 2009-07-09 | 2013-01-08 | Enanta Pharmaceuticals, Inc. | Proline substituted cyclosporin analogues |
| US8685917B2 (en) * | 2009-07-09 | 2014-04-01 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| EP2569313A1 (de) | 2010-05-12 | 2013-03-20 | Vertex Pharmaceuticals Incorporated | Als art-kinasehemmer nützliche verbindungen |
| LT2651965T (lt) | 2010-12-15 | 2019-01-10 | Contravir Pharmaceuticals, Inc. | Ciklosporino analogo molekulės su modifikuotomis 1 ir 3 aminorūgštimis |
| RU2018108589A (ru) | 2011-09-30 | 2019-02-25 | Вертекс Фармасьютикалз Инкорпорейтед | Лечение рака поджелудочной железы и немелкоклеточного рака легкого ингибиторами atr |
| EP3878851A1 (de) | 2011-09-30 | 2021-09-15 | Vertex Pharmaceuticals Incorporated | Verfahren zur herstellung von verbindungen welche als hemmer der atr-kinase nützlich sind |
| PT2833973T (pt) | 2012-04-05 | 2017-12-21 | Vertex Pharma | Compostos úteis como inibidores da cinase atr e terapias de combinação dos mesmos |
| AR090964A1 (es) * | 2012-05-09 | 2014-12-17 | Novartis Ag | Proceso para la elaboracion de undecapeptidos ciclicos |
| CA2874548A1 (en) | 2012-06-01 | 2013-12-05 | Allergan, Inc. | Cyclosporin a analogs |
| WO2014055756A1 (en) | 2012-10-04 | 2014-04-10 | Vertex Pharmaceuticals Incorporated | Method for measuring atr inhibition mediated increases in dna damage |
| WO2016112321A1 (en) | 2015-01-08 | 2016-07-14 | Allergan, Inc. | Cyclosporin derivatives wherein the mebmt sidechain has been cyclized |
| EP3355926B1 (de) | 2015-09-30 | 2025-12-24 | Vertex Pharmaceuticals Inc. | Kombination von dna-schädigenden mitteln und atr-inhibitoren zur verwendung in einem verfahren zur behandlung von krebs |
| CN107176970B (zh) * | 2017-07-06 | 2019-11-19 | 中国医药集团总公司四川抗菌素工业研究所 | 一种树脂催化法合成伪脯氨酸杂环肽的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE43335T1 (de) * | 1980-02-14 | 1989-06-15 | Sandoz Ag | Peptide die einen (1s,2r,3r)- oder (1r,2s,3s)-1nitrilo-1-carbonyl-3-methyl-2-oxyheptan oder hept-5-en-rest enthalten brauchbar in totaler synsthese von cyclosporinen, und verfahren zu ihrer herstellung. |
| US4798823A (en) * | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
| GB8717300D0 (en) * | 1987-07-22 | 1987-08-26 | Nat Res Dev | Cyclosporins |
| USRE40987E1 (en) * | 1998-07-01 | 2009-11-17 | Debiopharm S.A. | Cyclosporin with improved activity profile |
-
2000
- 2000-02-07 WO PCT/IB2000/000133 patent/WO2000046239A1/fr not_active Ceased
- 2000-02-07 AU AU21253/00A patent/AU2125300A/en not_active Abandoned
- 2000-02-07 ES ES00901297T patent/ES2267492T3/es not_active Expired - Lifetime
- 2000-02-07 AT AT00901297T patent/ATE330968T1/de not_active IP Right Cessation
- 2000-02-07 DE DE60028936T patent/DE60028936T2/de not_active Expired - Fee Related
- 2000-02-07 DK DK00901297T patent/DK1150999T3/da active
- 2000-02-07 PT PT00901297T patent/PT1150999E/pt unknown
- 2000-02-07 US US09/890,636 patent/US6790935B1/en not_active Expired - Fee Related
- 2000-02-07 EP EP00901297A patent/EP1150999B1/de not_active Expired - Lifetime
-
2006
- 2006-09-14 CY CY20061101311T patent/CY1105452T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1150999B1 (de) | 2006-06-21 |
| PT1150999E (pt) | 2006-10-31 |
| AU2125300A (en) | 2000-08-25 |
| ES2267492T3 (es) | 2007-03-16 |
| DK1150999T3 (da) | 2006-10-30 |
| US6790935B1 (en) | 2004-09-14 |
| EP1150999A1 (de) | 2001-11-07 |
| CY1105452T1 (el) | 2010-04-28 |
| DE60028936D1 (de) | 2006-08-03 |
| DE60028936T2 (de) | 2007-01-11 |
| WO2000046239A1 (fr) | 2000-08-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE330968T1 (de) | Cyclosporin-derivate und verfahren zu deren herstellung | |
| DE69803721D1 (de) | P-typ Stickstoff-Verbindungshalbleiter und Verfahren zu dessen Herstellung | |
| NO20020348D0 (no) | Peptid acceptor ligeringsmetoder | |
| DE60011875D1 (de) | System und verfahren zum ermöglichen sicherer verbindungen für h.323 voip anrufe | |
| ATE440863T1 (de) | Chemokine peptide, varianten, derivate und analoge. ihre verwendung in methode für die hemmung oder erhíhung von einer entzündungsreaktion | |
| DE69812489D1 (de) | Korrosionsbeständiges Bauteil, Waferträger und Verfahren zu deren Herstellung | |
| ATE327443T1 (de) | Befestigungsmittel und verfahren zu seiner herstellung | |
| DK1091975T3 (da) | Ny cyclosporin med forbedret aktivitetsprofil | |
| NO20014508D0 (no) | Fremgangsmåte for acylering av peptider, og nye acyleringsmidler | |
| DZ2196A1 (fr) | Compositions nanoparticulaires de cyclosporine a. | |
| FI980862A0 (fi) | Kiraalisia metyylifenyylioksatsolidinoneja | |
| DK0909312T3 (da) | Fremgangsmåde til fremstilling af polypeptider | |
| ATE368688T1 (de) | Peptide, deren herstellung und verwendung zur bindung von immunglobulinen | |
| DE69906938D1 (de) | Glococorticoid selektive entzündungshemmende mittel | |
| ATE509886T1 (de) | Peptidnanostrukturen, verfahren zu deren herstellung und verwendung | |
| ATE398630T1 (de) | Zyklische conotoxin-peptide | |
| ATE313557T1 (de) | Modifiziertes, als medikamentvorstufe anwendbares cyclosporin und dessen verwendung | |
| TR199801954T2 (xx) | Eprosartan dihidrat ve �retimi ve form�lasyonu i�in bir proses. | |
| CY1111802T1 (el) | Πρωτεϊνη συμμετεχουσα σε αποκατασταση γονιμοτητας φυτου με κυτταροπλασματικη ανδροστειροτητα και γονιδιο που την κωδικοποιει | |
| DE60023860D1 (de) | Verfahren zur herstellung von rekombinanten peptiden | |
| DE69820184D1 (de) | Lichtemittierendes Halbleiterbauelement und Verfahren zu dessen Herstellung | |
| GB9914045D0 (en) | Novel compounds | |
| DE69808475D1 (de) | Aminosäurederivate zur behandlung von schlaganfall | |
| DE60034885D1 (de) | Enzymlauge und verfahren zu deren herstellung, enzymzubereitung, proteasezubereitungen und proteaseproduzierendes bakterium | |
| IL139604A (en) | Fibrinogen-beta chain derived peptide, compositions comprising same and use thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1150999 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |