ATE330968T1 - Cyclosporin-derivate und verfahren zu deren herstellung - Google Patents
Cyclosporin-derivate und verfahren zu deren herstellungInfo
- Publication number
- ATE330968T1 ATE330968T1 AT00901297T AT00901297T ATE330968T1 AT E330968 T1 ATE330968 T1 AT E330968T1 AT 00901297 T AT00901297 T AT 00901297T AT 00901297 T AT00901297 T AT 00901297T AT E330968 T1 ATE330968 T1 AT E330968T1
- Authority
- AT
- Austria
- Prior art keywords
- production
- derivatives
- cyclosporine derivatives
- relates
- cyclosporine
- Prior art date
Links
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical class CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 title abstract 2
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/64—Cyclic peptides containing only normal peptide links
- C07K7/645—Cyclosporins; Related peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH22099 | 1999-02-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE330968T1 true ATE330968T1 (de) | 2006-07-15 |
Family
ID=4182021
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT00901297T ATE330968T1 (de) | 1999-02-05 | 2000-02-07 | Cyclosporin-derivate und verfahren zu deren herstellung |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US6790935B1 (de) |
| EP (1) | EP1150999B1 (de) |
| AT (1) | ATE330968T1 (de) |
| AU (1) | AU2125300A (de) |
| CY (1) | CY1105452T1 (de) |
| DE (1) | DE60028936T2 (de) |
| DK (1) | DK1150999T3 (de) |
| ES (1) | ES2267492T3 (de) |
| PT (1) | PT1150999E (de) |
| WO (1) | WO2000046239A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60208180T2 (de) * | 2001-04-20 | 2006-08-17 | Debiopharm S.A. | Modifiziertes, als medikamentvorstufe anwendbares cyclosporin und dessen verwendung |
| SI1853296T1 (sl) * | 2005-01-10 | 2012-10-30 | Debiopharm Sa | Uporaba cikličnega undekapeptida za pripravo zdravila za dajanje med miokardnimi ishemičnimi dogodki |
| BRPI0605658B8 (pt) * | 2006-12-29 | 2021-05-25 | Embrapa Pesquisa Agropecuaria | peptídeo antibiótico rico em glicina derivado de planta |
| US8153815B2 (en) | 2008-10-07 | 2012-04-10 | Hoffman-La Roche Inc. | Pseudoproline dipeptides |
| BRPI0924084B1 (pt) | 2008-12-19 | 2021-12-21 | Vertex Pharmaceuticals Incorporated | Derivados de pirazina e composição farmacêutica que os compreende |
| US8349312B2 (en) * | 2009-07-09 | 2013-01-08 | Enanta Pharmaceuticals, Inc. | Proline substituted cyclosporin analogues |
| US8685917B2 (en) * | 2009-07-09 | 2014-04-01 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| US8367053B2 (en) * | 2009-07-09 | 2013-02-05 | Enanta Pharmaceuticals, Inc. | Cyclosporin analogues |
| AU2011253025A1 (en) | 2010-05-12 | 2012-11-29 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of ATR kinase |
| JP6144627B2 (ja) | 2010-12-15 | 2017-06-07 | コントラヴィア ファーマシューティカルズ、インク． | アミノ酸１および３で修飾されたシクロスポリン類似体分子 |
| SG10201606774UA (en) | 2011-09-30 | 2016-10-28 | Vertex Pharma | Processes for making compounds useful as inhibitors of atr kinase |
| IN2014CN02501A (de) | 2011-09-30 | 2015-06-26 | Vertex Pharma | |
| US20140044802A1 (en) | 2012-04-05 | 2014-02-13 | Vertex Pharmaceuticals Incorporated | Compounds useful as inhibitors of atr kinase and combination therapies thereof |
| AR090964A1 (es) * | 2012-05-09 | 2014-12-17 | Novartis Ag | Proceso para la elaboracion de undecapeptidos ciclicos |
| EP2855508B1 (de) | 2012-06-01 | 2018-02-14 | Allergan, Inc. | Cyclosporin-a-analoga |
| DK2904406T3 (en) | 2012-10-04 | 2018-06-18 | Vertex Pharma | METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE |
| WO2016112321A1 (en) | 2015-01-08 | 2016-07-14 | Allergan, Inc. | Cyclosporin derivatives wherein the mebmt sidechain has been cyclized |
| KR102678021B1 (ko) | 2015-09-30 | 2024-06-26 | 버텍스 파마슈티칼스 인코포레이티드 | Dna 손상제와 병용되는, atr 저해제를 포함하는 암 치료용 약제학적 조성물 |
| CN107176970B (zh) * | 2017-07-06 | 2019-11-19 | 中国医药集团总公司四川抗菌素工业研究所 | 一种树脂催化法合成伪脯氨酸杂环肽的方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0034567B1 (de) * | 1980-02-14 | 1984-11-07 | Sandoz Ag | Verfahren zur Totalsynthese von Cyclosporinen und neue Cyclosporine |
| US4798823A (en) | 1987-06-03 | 1989-01-17 | Merck & Co., Inc. | New cyclosporin analogs with modified "C-9 amino acids" |
| GB8717300D0 (en) * | 1987-07-22 | 1987-08-26 | Nat Res Dev | Cyclosporins |
| PT1091975E (pt) | 1998-07-01 | 2006-05-31 | Debiopharm Sa | Nova ciclosporina com um perfil de actividade melhorado |
-
2000
- 2000-02-07 ES ES00901297T patent/ES2267492T3/es not_active Expired - Lifetime
- 2000-02-07 AU AU21253/00A patent/AU2125300A/en not_active Abandoned
- 2000-02-07 DE DE60028936T patent/DE60028936T2/de not_active Expired - Fee Related
- 2000-02-07 WO PCT/IB2000/000133 patent/WO2000046239A1/fr not_active Ceased
- 2000-02-07 EP EP00901297A patent/EP1150999B1/de not_active Expired - Lifetime
- 2000-02-07 DK DK00901297T patent/DK1150999T3/da active
- 2000-02-07 US US09/890,636 patent/US6790935B1/en not_active Expired - Fee Related
- 2000-02-07 AT AT00901297T patent/ATE330968T1/de not_active IP Right Cessation
- 2000-02-07 PT PT00901297T patent/PT1150999E/pt unknown
-
2006
- 2006-09-14 CY CY20061101311T patent/CY1105452T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2000046239A1 (fr) | 2000-08-10 |
| US6790935B1 (en) | 2004-09-14 |
| DE60028936D1 (de) | 2006-08-03 |
| EP1150999A1 (de) | 2001-11-07 |
| PT1150999E (pt) | 2006-10-31 |
| CY1105452T1 (el) | 2010-04-28 |
| DK1150999T3 (da) | 2006-10-30 |
| AU2125300A (en) | 2000-08-25 |
| ES2267492T3 (es) | 2007-03-16 |
| DE60028936T2 (de) | 2007-01-11 |
| EP1150999B1 (de) | 2006-06-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
Ref document number: 1150999 Country of ref document: EP |
|
| REN | Ceased due to non-payment of the annual fee |