ATE330968T1 - Cyclosporin-derivate und verfahren zu deren herstellung - Google Patents

Cyclosporin-derivate und verfahren zu deren herstellung

Info

Publication number
ATE330968T1
ATE330968T1 AT00901297T AT00901297T ATE330968T1 AT E330968 T1 ATE330968 T1 AT E330968T1 AT 00901297 T AT00901297 T AT 00901297T AT 00901297 T AT00901297 T AT 00901297T AT E330968 T1 ATE330968 T1 AT E330968T1
Authority
AT
Austria
Prior art keywords
production
derivatives
cyclosporine derivatives
relates
cyclosporine
Prior art date
Application number
AT00901297T
Other languages
English (en)
Inventor
Manfred Mutter
Roland M Wenger
Jean-Francois Guichou
De Chimie Batiment
Michael Keller
Chemistry
Thomas Ruckle
Torsten Woehr
Original Assignee
Debiopharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Sa filed Critical Debiopharm Sa
Application granted granted Critical
Publication of ATE330968T1 publication Critical patent/ATE330968T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
AT00901297T 1999-02-05 2000-02-07 Cyclosporin-derivate und verfahren zu deren herstellung ATE330968T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH22099 1999-02-05

Publications (1)

Publication Number Publication Date
ATE330968T1 true ATE330968T1 (de) 2006-07-15

Family

ID=4182021

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00901297T ATE330968T1 (de) 1999-02-05 2000-02-07 Cyclosporin-derivate und verfahren zu deren herstellung

Country Status (10)

Country Link
US (1) US6790935B1 (de)
EP (1) EP1150999B1 (de)
AT (1) ATE330968T1 (de)
AU (1) AU2125300A (de)
CY (1) CY1105452T1 (de)
DE (1) DE60028936T2 (de)
DK (1) DK1150999T3 (de)
ES (1) ES2267492T3 (de)
PT (1) PT1150999E (de)
WO (1) WO2000046239A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6995139B2 (en) * 2001-04-20 2006-02-07 Debiopharm S.A. Cyclic undecapeptide pro-drugs and uses thereof
ES2387682T3 (es) * 2005-01-10 2012-09-28 Debiopharm S.A. Utilización de un undecapéptido cíclico para la preparación de un medicamento administrable durante situaciones isquémicas miocárdicas
BRPI0605658B8 (pt) * 2006-12-29 2021-05-25 Embrapa Pesquisa Agropecuaria peptídeo antibiótico rico em glicina derivado de planta
US8153815B2 (en) * 2008-10-07 2012-04-10 Hoffman-La Roche Inc. Pseudoproline dipeptides
CN102300862B (zh) 2008-12-19 2016-11-23 沃泰克斯药物股份有限公司 用作atr激酶抑制剂的化合物
US8349312B2 (en) * 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8685917B2 (en) * 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8367053B2 (en) * 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
NZ603477A (en) 2010-05-12 2014-09-26 Vertex Pharma Compounds useful as inhibitors of atr kinase
HUE042490T2 (hu) 2010-12-15 2019-07-29 Contravir Pharmaceuticals Inc 1-es és 3-as aminosav-pozícióban módosított ciklosporin analóg molekulák
MX2014003785A (es) 2011-09-30 2014-07-24 Vertex Phamaceuticals Inc Tratamiento del cancer de pancreas y del cancer de pulmon de celulas no pequeñas con inhibidores de atr.
EP2940017B1 (de) 2011-09-30 2019-08-28 Vertex Pharmaceuticals Incorporated Verfahren zur Herstellung von als Hemmer der ATR-Kinase nützlichen Verbindungen
NZ720511A (en) 2012-04-05 2016-12-23 Vertex Pharma Compounds useful as inhibitors of atr kinase and combination therapies thereof
AR090964A1 (es) 2012-05-09 2014-12-17 Novartis Ag Proceso para la elaboracion de undecapeptidos ciclicos
AU2013267435B2 (en) 2012-06-01 2017-11-09 Allergan, Inc. Cyclosporin A analogs
DK2904406T3 (en) 2012-10-04 2018-06-18 Vertex Pharma METHOD OF DETERMINING THE ATR INHIBITION, INCREASED DNA DAMAGE
US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
WO2017059357A1 (en) 2015-09-30 2017-04-06 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna damaging agents and atr inhibitors
CN107176970B (zh) * 2017-07-06 2019-11-19 中国医药集团总公司四川抗菌素工业研究所 一种树脂催化法合成伪脯氨酸杂环肽的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE43335T1 (de) 1980-02-14 1989-06-15 Sandoz Ag Peptide die einen (1s,2r,3r)- oder (1r,2s,3s)-1nitrilo-1-carbonyl-3-methyl-2-oxyheptan oder hept-5-en-rest enthalten brauchbar in totaler synsthese von cyclosporinen, und verfahren zu ihrer herstellung.
US4798823A (en) * 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
GB8717300D0 (en) 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
JP4350898B2 (ja) 1998-07-01 2009-10-21 デビオファーム・ソシエテ・アノニム 活性の特徴が改善された新規のシクロスポリン

Also Published As

Publication number Publication date
EP1150999A1 (de) 2001-11-07
DE60028936T2 (de) 2007-01-11
DE60028936D1 (de) 2006-08-03
CY1105452T1 (el) 2010-04-28
ES2267492T3 (es) 2007-03-16
WO2000046239A1 (fr) 2000-08-10
DK1150999T3 (da) 2006-10-30
PT1150999E (pt) 2006-10-31
US6790935B1 (en) 2004-09-14
AU2125300A (en) 2000-08-25
EP1150999B1 (de) 2006-06-21

Similar Documents

Publication Publication Date Title
ATE330968T1 (de) Cyclosporin-derivate und verfahren zu deren herstellung
DE69803721D1 (de) P-typ Stickstoff-Verbindungshalbleiter und Verfahren zu dessen Herstellung
NO20020348D0 (no) Peptid acceptor ligeringsmetoder
ATE440863T1 (de) Chemokine peptide, varianten, derivate und analoge. ihre verwendung in methode für die hemmung oder erhíhung von einer entzündungsreaktion
ATE327443T1 (de) Befestigungsmittel und verfahren zu seiner herstellung
NO20100324L (no) Fremgangsmate for trinnvis festing av polyetylenglykol (PEG) andeler i serie til et polypeptid
DK1091975T3 (da) Ny cyclosporin med forbedret aktivitetsprofil
HUP0300246A2 (en) Delivery system
NO20014508L (no) Fremgangsmåte for acylering av peptider, og nye acyleringsmidler
ATE368688T1 (de) Peptide, deren herstellung und verwendung zur bindung von immunglobulinen
DK0909312T3 (da) Fremgangsmåde til fremstilling af polypeptider
TR199801954T2 (xx) Eprosartan dihidrat ve �retimi ve form�lasyonu i�in bir proses.
CY1111802T1 (el) Πρωτεϊνη συμμετεχουσα σε αποκατασταση γονιμοτητας φυτου με κυτταροπλασματικη ανδροστειροτητα και γονιδιο που την κωδικοποιει
ATE398630T1 (de) Zyklische conotoxin-peptide
ATE509886T1 (de) Peptidnanostrukturen, verfahren zu deren herstellung und verwendung
DE60233478D1 (de) Gruppe iii nitrid-basiertes lichtemittierendes halbleiterbauelement und verfahren zu dessen herstellung
DE69820184D1 (de) Lichtemittierendes Halbleiterbauelement und Verfahren zu dessen Herstellung
ATE313557T1 (de) Modifiziertes, als medikamentvorstufe anwendbares cyclosporin und dessen verwendung
MY141607A (en) Lactam compound
HK1041686A1 (en) N-arylsulfonyl amino acid omega amedes.
DE69808475D1 (de) Aminosäurederivate zur behandlung von schlaganfall
WO2000077032A3 (en) Spermine:peptide-based surfactant compounds
IL139604A (en) Fibrinogen-beta chain derived peptide, compositions comprising same and use thereof
WO2001087239A3 (en) Methods of affecting laminin 5 processing
DK1117682T3 (da) Chi-conotoksin-peptider som inhibitorer af neuronale amintransportere

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 1150999

Country of ref document: EP

REN Ceased due to non-payment of the annual fee