CY1105452T1 - Παραγωγα της κυκλοσπορινης και μεθοδος παρασκευης των εν λογω παραγωγων - Google Patents

Παραγωγα της κυκλοσπορινης και μεθοδος παρασκευης των εν λογω παραγωγων

Info

Publication number
CY1105452T1
CY1105452T1 CY20061101311T CY061101311T CY1105452T1 CY 1105452 T1 CY1105452 T1 CY 1105452T1 CY 20061101311 T CY20061101311 T CY 20061101311T CY 061101311 T CY061101311 T CY 061101311T CY 1105452 T1 CY1105452 T1 CY 1105452T1
Authority
CY
Cyprus
Prior art keywords
derivatives
cyclosporin
preparation
cyclosporin derivatives
pseudoproline
Prior art date
Application number
CY20061101311T
Other languages
English (en)
Inventor
Manfred Mutter
Roland M. Wenger
Jean-Francois Guichou
Michael Keller
Thomas Ruckle
Torsten Woehr
Original Assignee
Debiopharm S.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm S.A. filed Critical Debiopharm S.A.
Publication of CY1105452T1 publication Critical patent/CY1105452T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Η παρούσα εφεύρεση αφορά παράγωγα της κυκλοσπορίνης των οποίων η πεπτιδική αλληλουχία περιλαμβάνει τουλάχιστον ένα κατάλοιπο μη φυσικού αμινοξέως τύπου ψευδοπρολίνης καθώς και μία μέθοδο παρασκευής των εν λόγω παραγώγων.
CY20061101311T 1999-02-05 2006-09-14 Παραγωγα της κυκλοσπορινης και μεθοδος παρασκευης των εν λογω παραγωγων CY1105452T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH22099 1999-02-05
PCT/IB2000/000133 WO2000046239A1 (fr) 1999-02-05 2000-02-07 Derives de cyclosporine et procede de preparation desdits derives

Publications (1)

Publication Number Publication Date
CY1105452T1 true CY1105452T1 (el) 2010-04-28

Family

ID=4182021

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20061101311T CY1105452T1 (el) 1999-02-05 2006-09-14 Παραγωγα της κυκλοσπορινης και μεθοδος παρασκευης των εν λογω παραγωγων

Country Status (10)

Country Link
US (1) US6790935B1 (el)
EP (1) EP1150999B1 (el)
AT (1) ATE330968T1 (el)
AU (1) AU2125300A (el)
CY (1) CY1105452T1 (el)
DE (1) DE60028936T2 (el)
DK (1) DK1150999T3 (el)
ES (1) ES2267492T3 (el)
PT (1) PT1150999E (el)
WO (1) WO2000046239A1 (el)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL158385A0 (en) * 2001-04-20 2004-05-12 Debiopharm Sa Modified cyclosporin which can be used as a pro-drug and use thereof
SI1853296T1 (sl) * 2005-01-10 2012-10-30 Debiopharm Sa Uporaba cikličnega undekapeptida za pripravo zdravila za dajanje med miokardnimi ishemičnimi dogodki
BRPI0605658B8 (pt) * 2006-12-29 2021-05-25 Embrapa Pesquisa Agropecuaria peptídeo antibiótico rico em glicina derivado de planta
US8153815B2 (en) 2008-10-07 2012-04-10 Hoffman-La Roche Inc. Pseudoproline dipeptides
CA2747252C (en) 2008-12-19 2018-09-18 Vertex Pharmaceuticals Incorporated Pyrazine derivatives useful as inhibitors of atr kinase
US8685917B2 (en) * 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8367053B2 (en) * 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8349312B2 (en) * 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
CA2798763A1 (en) 2010-05-12 2011-11-17 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of atr kinase
DK2651965T3 (en) 2010-12-15 2019-02-18 Contravir Pharmaceuticals Inc CYCLOSPORIN ANALOGUAL MODULES MODIFIED BY AMINO ACID 1 AND 3
US9035053B2 (en) 2011-09-30 2015-05-19 Vertex Pharmaceuticals Incorporated Processes for making compounds useful as inhibitors of ATR kinase
AU2012315384B2 (en) 2011-09-30 2017-08-10 Vertex Pharmaceuticals Incorporated Treating pancreatic cancer and non-small cell lung cancer with ATR inhibitors
LT2833973T (lt) 2012-04-05 2018-02-12 Vertex Pharmaceuticals Incorporated Junginiai, tinkami naudoti kaip atr kinazės inhibitoriai, ir jų kombinuotas gydymas
AR090964A1 (es) * 2012-05-09 2014-12-17 Novartis Ag Proceso para la elaboracion de undecapeptidos ciclicos
AU2013267435B2 (en) 2012-06-01 2017-11-09 Allergan, Inc. Cyclosporin A analogs
EP2904406B1 (en) 2012-10-04 2018-03-21 Vertex Pharmaceuticals Incorporated Method for measuring atr inhibition mediated increases in dna damage
TW201639873A (zh) 2015-01-08 2016-11-16 歐樂根公司 Ｍｅｂｍｔ側鏈已環化之環孢菌素衍生物
JP7187308B2 (ja) 2015-09-30 2022-12-12 バーテックス ファーマシューティカルズ インコーポレイテッド Ｄｎａ損傷剤とａｔｒ阻害剤との組み合わせを使用する、がんを処置するための方法
CN107176970B (zh) * 2017-07-06 2019-11-19 中国医药集团总公司四川抗菌素工业研究所 一种树脂催化法合成伪脯氨酸杂环肽的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0034567B1 (en) 1980-02-14 1984-11-07 Sandoz Ag A method for the total synthesis of cyclosporins and novel cyclosporins
US4798823A (en) 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
GB8717300D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
DE69928938T2 (de) * 1998-07-01 2006-08-17 Debiopharm S.A. Neues cyclosporin mit verbesserter wirkung

Also Published As

Publication number Publication date
DE60028936D1 (de) 2006-08-03
DK1150999T3 (da) 2006-10-30
AU2125300A (en) 2000-08-25
ES2267492T3 (es) 2007-03-16
WO2000046239A1 (fr) 2000-08-10
ATE330968T1 (de) 2006-07-15
US6790935B1 (en) 2004-09-14
DE60028936T2 (de) 2007-01-11
EP1150999B1 (fr) 2006-06-21
EP1150999A1 (fr) 2001-11-07
PT1150999E (pt) 2006-10-31

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