DK1150999T3 - Cyclosporinderivater og fremgangsmåde til fremstilling deraf - Google Patents

Cyclosporinderivater og fremgangsmåde til fremstilling deraf

Info

Publication number
DK1150999T3
DK1150999T3 DK00901297T DK00901297T DK1150999T3 DK 1150999 T3 DK1150999 T3 DK 1150999T3 DK 00901297 T DK00901297 T DK 00901297T DK 00901297 T DK00901297 T DK 00901297T DK 1150999 T3 DK1150999 T3 DK 1150999T3
Authority
DK
Denmark
Prior art keywords
preparation
cyclosporin derivatives
derivatives
relates
cyclosporin
Prior art date
Application number
DK00901297T
Other languages
English (en)
Inventor
Jean-Francois Guichou
Manfred Mutter
Roland M Wenger
Michael C O A Miller Keller
Thomas Ruckle
Torsten Woehr
Original Assignee
Debiopharm Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Debiopharm Sa filed Critical Debiopharm Sa
Application granted granted Critical
Publication of DK1150999T3 publication Critical patent/DK1150999T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C07K7/645—Cyclosporins; Related peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DK00901297T 1999-02-05 2000-02-07 Cyclosporinderivater og fremgangsmåde til fremstilling deraf DK1150999T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CH22099 1999-02-05

Publications (1)

Publication Number Publication Date
DK1150999T3 true DK1150999T3 (da) 2006-10-30

Family

ID=4182021

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00901297T DK1150999T3 (da) 1999-02-05 2000-02-07 Cyclosporinderivater og fremgangsmåde til fremstilling deraf

Country Status (10)

Country Link
US (1) US6790935B1 (da)
EP (1) EP1150999B1 (da)
AT (1) ATE330968T1 (da)
AU (1) AU2125300A (da)
CY (1) CY1105452T1 (da)
DE (1) DE60028936T2 (da)
DK (1) DK1150999T3 (da)
ES (1) ES2267492T3 (da)
PT (1) PT1150999E (da)
WO (1) WO2000046239A1 (da)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1507451A (zh) * 2001-04-20 2004-06-23 �±Ȱ·�ķ�ɷ����޹�˾ 可用作前体药物的修饰环孢菌素及其应用
WO2006072639A1 (fr) * 2005-01-10 2006-07-13 Debiopharm S.A. Utilisation d’un undecapeptide cyclique pour la preparation d’un médicament administrable lors de situations ischemiques myocardiques
BRPI0605658B8 (pt) * 2006-12-29 2021-05-25 Embrapa Pesquisa Agropecuaria peptídeo antibiótico rico em glicina derivado de planta
US8153815B2 (en) * 2008-10-07 2012-04-10 Hoffman-La Roche Inc. Pseudoproline dipeptides
CA3013000C (en) 2008-12-19 2022-12-13 Vertex Pharmaceuticals Incorporated Pyrazine derivatives useful as inhibitors of atr kinase
US8349312B2 (en) * 2009-07-09 2013-01-08 Enanta Pharmaceuticals, Inc. Proline substituted cyclosporin analogues
US8367053B2 (en) * 2009-07-09 2013-02-05 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
US8685917B2 (en) * 2009-07-09 2014-04-01 Enanta Pharmaceuticals, Inc. Cyclosporin analogues
SG185524A1 (en) 2010-05-12 2012-12-28 Vertex Pharma Compounds useful as inhibitors of atr kinase
PT2651965T (pt) 2010-12-15 2019-01-28 Contravir Pharmaceuticals Inc Moléculas analógas de ciclosporinas modificadas ao nivel dos aminoácidos 1 e 3
WO2013049726A2 (en) 2011-09-30 2013-04-04 Vertex Pharmaceuticals Incorporated Processes for making compounds useful as inhibitors of atr kinase
CA2850491C (en) 2011-09-30 2020-10-27 Vertex Pharmaceuticals Incorporated Treating pancreatic cancer and non-small cell lung cancer with atr inhibiors
MX358818B (es) 2012-04-05 2018-09-05 Vertex Pharma Compuestos utiles como inhibidores de cinasa ataxia telangiectasia mutada y rad3 relacionados (atr) y terapias de combinacion de estos.
AR090964A1 (es) * 2012-05-09 2014-12-17 Novartis Ag Proceso para la elaboracion de undecapeptidos ciclicos
WO2013181339A2 (en) 2012-06-01 2013-12-05 Allergan, Inc. Cyclosporin a analogs
WO2014055756A1 (en) 2012-10-04 2014-04-10 Vertex Pharmaceuticals Incorporated Method for measuring atr inhibition mediated increases in dna damage
US9914755B2 (en) 2015-01-08 2018-03-13 Allergan, Inc. Cyclosporin derivatives wherein the MeBmt sidechain has been cyclized
CA3000684A1 (en) 2015-09-30 2017-04-06 Vertex Pharmaceuticals Incorporated Method for treating cancer using a combination of dna damaging agents and atr inhibitors
CN107176970B (zh) * 2017-07-06 2019-11-19 中国医药集团总公司四川抗菌素工业研究所 一种树脂催化法合成伪脯氨酸杂环肽的方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU548156B2 (en) * 1980-02-14 1985-11-28 Novartis Ag Cyclo sporin
US4798823A (en) 1987-06-03 1989-01-17 Merck & Co., Inc. New cyclosporin analogs with modified "C-9 amino acids"
GB8717300D0 (en) * 1987-07-22 1987-08-26 Nat Res Dev Cyclosporins
USRE40987E1 (en) 1998-07-01 2009-11-17 Debiopharm S.A. Cyclosporin with improved activity profile

Also Published As

Publication number Publication date
EP1150999A1 (fr) 2001-11-07
AU2125300A (en) 2000-08-25
DE60028936D1 (de) 2006-08-03
DE60028936T2 (de) 2007-01-11
PT1150999E (pt) 2006-10-31
WO2000046239A1 (fr) 2000-08-10
CY1105452T1 (el) 2010-04-28
US6790935B1 (en) 2004-09-14
EP1150999B1 (fr) 2006-06-21
ES2267492T3 (es) 2007-03-16
ATE330968T1 (de) 2006-07-15

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