DK1089968T3 - Thyroideahormonanaloger og fremgangsmåder til deres fremstilling - Google Patents
Thyroideahormonanaloger og fremgangsmåder til deres fremstillingInfo
- Publication number
- DK1089968T3 DK1089968T3 DK99932002T DK99932002T DK1089968T3 DK 1089968 T3 DK1089968 T3 DK 1089968T3 DK 99932002 T DK99932002 T DK 99932002T DK 99932002 T DK99932002 T DK 99932002T DK 1089968 T3 DK1089968 T3 DK 1089968T3
- Authority
- DK
- Denmark
- Prior art keywords
- preparation
- methods
- thyroid hormone
- hormone analogues
- analogues
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- AUYYCJSJGJYCDS-LBPRGKRZSA-N Thyrolar Chemical class IC1=CC(C[C@H](N)C(O)=O)=CC(I)=C1OC1=CC=C(O)C(I)=C1 AUYYCJSJGJYCDS-LBPRGKRZSA-N 0.000 title abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C321/00—Thiols, sulfides, hydropolysulfides or polysulfides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
- C07C69/67—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of saturated acids
- C07C69/708—Ethers
- C07C69/712—Ethers the hydroxy group of the ester being etherified with a hydroxy compound having the hydroxy group bound to a carbon atom of a six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
- A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/11—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/16—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
- C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
- C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
- C07C59/70—Ethers of hydroxy-acetic acid, e.g. substitutes on the ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
- C07F7/1804—Compounds having Si-O-C linkages
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Endocrinology (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9118598P | 1998-06-30 | 1998-06-30 | |
| EP99932002A EP1089968B1 (en) | 1998-06-30 | 1999-06-28 | Thyroid hormone analogues and methods for their preparation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1089968T3 true DK1089968T3 (da) | 2005-08-22 |
Family
ID=22226506
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK99932002T DK1089968T3 (da) | 1998-06-30 | 1999-06-28 | Thyroideahormonanaloger og fremgangsmåder til deres fremstilling |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US6107517A (da) |
| EP (2) | EP1089968B1 (da) |
| JP (1) | JP2002519340A (da) |
| KR (1) | KR20010053277A (da) |
| AT (1) | ATE293595T1 (da) |
| AU (1) | AU4840199A (da) |
| CA (1) | CA2335551C (da) |
| DE (1) | DE69924846T2 (da) |
| DK (1) | DK1089968T3 (da) |
| ES (1) | ES2241294T3 (da) |
| IL (1) | IL140140A0 (da) |
| PT (1) | PT1089968E (da) |
| WO (1) | WO2000000468A1 (da) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5883294A (en) * | 1997-06-18 | 1999-03-16 | The Regeants Of The University Of California | Selective thyroid hormone analogs |
| US6680344B1 (en) | 1999-06-01 | 2004-01-20 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using diphenylmethane derivatives |
| JP2003500433A (ja) * | 1999-06-01 | 2003-01-07 | ザ・ユニバーシティ・オブ・テキサス・サウスウエスタン・メディカル・センター | ジフェニルメタン誘導体を用いる脱毛の処置方法 |
| US6723717B1 (en) | 1999-06-01 | 2004-04-20 | The University Of Texas Southwestern Medical Center | Sulfur-containing thyroxane derivatives and their use as hair growth promotors |
| US6646005B1 (en) | 1999-06-01 | 2003-11-11 | The University Of Texas Southwestern Medical Center | Method of treating hair loss using sulfonyl thyromimetic compounds |
| WO2002056880A1 (en) * | 2001-01-19 | 2002-07-25 | Cytokinetics, Inc. | Triphenylmethane kinesin inhibitors |
| US7302347B2 (en) * | 2002-12-10 | 2007-11-27 | The Regents Of The University Of California | Method for creating specific, high affinity nuclear receptor pharmaceuticals |
| SE526033C3 (sv) * | 2003-11-06 | 2009-12-08 | Metso Paper Inc | Silanordning och silkorg för silning av massasuspensioner |
| AU2006249350B2 (en) | 2003-11-19 | 2012-02-16 | Metabasis Therapeutics, Inc. | Thyromimetics for the treatment of fatty liver diseases |
| EP2428516A1 (en) * | 2003-11-19 | 2012-03-14 | Metabasis Therapeutics, Inc. | Novel phosphorus-containing thyromimetics |
| WO2006128056A2 (en) * | 2005-05-26 | 2006-11-30 | Metabasis Therapeutics, Inc. | Novel phosphinic acid-containing thyromimetics |
| WO2007002036A1 (en) * | 2005-06-24 | 2007-01-04 | Thomas Lavin | Tyroid hormone in burn and adipose deposites |
| WO2014178892A1 (en) | 2013-05-03 | 2014-11-06 | Scanlan Thomas S | Use of sobetirome in the treatment of x-linked adrenolenoleukodystrophy |
| HUE056357T2 (hu) | 2016-05-18 | 2022-02-28 | Univ Oregon Health & Science | Szobetirom származékok |
| MX2019005730A (es) | 2016-11-21 | 2019-10-21 | Viking Therapeutics Inc | Metodo para tratar enfermedad de almacenamiento de glucogeno. |
| EA201992703A1 (ru) | 2017-06-05 | 2020-04-15 | Вайкинг Терапьютикс, Инк. | Композиции для лечения фиброза |
| AU2019238090A1 (en) | 2018-03-22 | 2020-10-08 | Viking Therapeutics, Inc. | Crystalline forms and methods of producing crystalline forms of a compound |
| CN113423684A (zh) | 2018-12-12 | 2021-09-21 | 速通医疗公司 | 新型拟甲状腺素药 |
| US11667606B2 (en) | 2019-03-01 | 2023-06-06 | Autobahn Therapeutics, Inc. | Thyromimetics |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3332957A (en) * | 1964-09-02 | 1967-07-25 | Ciba Geigy Corp | Amino esters of substituted phenoxy acetic acids |
| JPS5195049A (en) * | 1975-02-12 | 1976-08-20 | * **********so*****no***tsu*****************************************ni*no | |
| US4323691A (en) * | 1979-10-09 | 1982-04-06 | Abbott Laboratories | Hydroxyaminomethyl derivatives of benzoyl di-substituted α-phenoxyalkanoyl esters |
| US5883294A (en) * | 1997-06-18 | 1999-03-16 | The Regeants Of The University Of California | Selective thyroid hormone analogs |
-
1999
- 1999-06-28 PT PT99932002T patent/PT1089968E/pt unknown
- 1999-06-28 ES ES99932002T patent/ES2241294T3/es not_active Expired - Lifetime
- 1999-06-28 EP EP99932002A patent/EP1089968B1/en not_active Expired - Lifetime
- 1999-06-28 IL IL14014099A patent/IL140140A0/xx unknown
- 1999-06-28 CA CA002335551A patent/CA2335551C/en not_active Expired - Fee Related
- 1999-06-28 DE DE69924846T patent/DE69924846T2/de not_active Expired - Lifetime
- 1999-06-28 DK DK99932002T patent/DK1089968T3/da active
- 1999-06-28 AU AU48401/99A patent/AU4840199A/en not_active Abandoned
- 1999-06-28 KR KR1020007014984A patent/KR20010053277A/ko not_active Application Discontinuation
- 1999-06-28 WO PCT/US1999/014627 patent/WO2000000468A1/en active IP Right Grant
- 1999-06-28 EP EP05008536A patent/EP1598334A1/en not_active Withdrawn
- 1999-06-28 AT AT99932002T patent/ATE293595T1/de not_active IP Right Cessation
- 1999-06-28 JP JP2000557229A patent/JP2002519340A/ja not_active Withdrawn
- 1999-06-30 US US09/345,673 patent/US6107517A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2335551A1 (en) | 2000-01-06 |
| EP1598334A1 (en) | 2005-11-23 |
| DE69924846T2 (de) | 2006-04-27 |
| EP1089968B1 (en) | 2005-04-20 |
| EP1089968A4 (en) | 2002-08-21 |
| ES2241294T3 (es) | 2005-10-16 |
| DE69924846D1 (de) | 2005-05-25 |
| IL140140A0 (en) | 2002-02-10 |
| PT1089968E (pt) | 2005-08-31 |
| US6107517A (en) | 2000-08-22 |
| WO2000000468A1 (en) | 2000-01-06 |
| CA2335551C (en) | 2009-03-03 |
| ATE293595T1 (de) | 2005-05-15 |
| EP1089968A1 (en) | 2001-04-11 |
| KR20010053277A (ko) | 2001-06-25 |
| JP2002519340A (ja) | 2002-07-02 |
| AU4840199A (en) | 2000-01-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DK1089968T3 (da) | Thyroideahormonanaloger og fremgangsmåder til deres fremstilling | |
| DK1149905T3 (da) | Fremgangsmåder og præparat til polypeptidteknologi | |
| DK0548114T5 (da) | Mometason-furoat-monohydrat, fremgangsmåde til fremtilling deraf og farmaceutiske præparater indeholdende dette | |
| YU19903A (sh) | Novi receptor nukleinskih kiselina i polipeptida | |
| EP0991618A4 (en) | SELECTIVE ANALOGS OF THYROID HORMONES | |
| DK146688D0 (da) | Blegemiddelaktivatorsammensaetning, detergentsammensaetning indeholdende samme fremgangsmaade til fremstilling af saadanne sammensaetninger | |
| DK573384A (da) | Sphingosinderivater, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende disse derivater | |
| IL149459A0 (en) | Recombinant gelatins | |
| DK0915898T3 (da) | Krystalform I af clarithromycin | |
| NO331093B1 (no) | Somatostatinanaloger, fremgangsmåte for fremstilling, farmasøytisk sammensetning og anvendelse derav. | |
| BR9401183A (pt) | Composto e formulação farmacêutica | |
| DK1010374T3 (da) | Fiberblanding til enterale sammensætninger | |
| DK165988C (da) | Modificerede egliner b og c, deres anvendelse som proteaseinhibitorer, fremgangsmaade til fremstilling deraf samt farmaceutiske praeparater indeholdende de modificerede egliner b og c | |
| DK605786A (da) | Stabiliserede human-vaevsplasminogenaktivator-praeparater | |
| UA66865C2 (uk) | Інденопіролокарбазоли, фармацевтична композиція, спосіб інгібування кіназної активності та спосіб лікування (варіанти) | |
| HK1050535A1 (en) | Novel oligosaccharides, preparation method and pharmaceutical compositions containing same | |
| DK0482097T3 (da) | Tensidpræparater og fremgangsmåder | |
| ES2159260A1 (es) | Nueva composicion de metanosulfonato de paroxetina | |
| DK1037613T3 (da) | Fremgangsmåde til fremstilling af farmaceutiske formuleringer, der indeholder en ekstrakt | |
| DK4287D0 (da) | Polyfluoralkylthiomethyl-forbindelser, fremgangsmaade til fremstilling deraf og anvendelse af saadanneforbindelser som overfladeaktive midler | |
| DK0972521T3 (da) | Farmaceutisk præparat, der indeholder interferon-gamma-stimulatorer | |
| DK0864653T3 (da) | Fremgangsmåde til fremstilling af 4-(4-(4-(hydroxydiphenyl)-1-piperidinyl)-1-hydroxybutyl)-alfa,alfa-dimethylphenyleddikesyre og phosphorylerede derivater deraf | |
| DK630088D0 (da) | Azelastinembonat, fremgangsmaade til fremstilling deraf og farmaceutiske praeparater med indhold af denne forbindelse som aktivt middel | |
| DK162889C (da) | Substituerede hexahydrobenzindenoazepiner, fremgangsmaader til fremstilling af saadanne forbindelser, farmaceutiske praeparater indeholdende forbindelserne, anvendelse af forbindelserne til fremstilling af farmaceutiske praeparater samt fremgangsmaade til fremstilling af saadanne farmaceutiske praeparater | |
| DK1284102T3 (da) | Sirupholdige sammensætninger og fremgangsmåder til fremstilling af samme |