JP5259537B2 - 大環状ｃ型肝炎セリンプロテアーゼ阻害薬 - Google Patents

大環状ｃ型肝炎セリンプロテアーゼ阻害薬 Download PDF

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Publication number
JP5259537B2
JP5259537B2 JP2009208935A JP2009208935A JP5259537B2 JP 5259537 B2 JP5259537 B2 JP 5259537B2 JP 2009208935 A JP2009208935 A JP 2009208935A JP 2009208935 A JP2009208935 A JP 2009208935A JP 5259537 B2 JP5259537 B2 JP 5259537B2
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Japan
Prior art keywords
carboxamide
yloxy
dioxo
pyrrolo
hexadecahydrocyclopropa
Prior art date
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Expired - Fee Related
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JP2009208935A
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English (en)
Japanese (ja)
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JP2010065035A (ja
JP2010065035A5 (enExample
Inventor
イーイン・クー
キース・エフ・マクダニエル
ホイ−チユイ・チエン
ジエイソン・ピー・シヤンレイ
デイル・ジエイ・ケンプ
デイビツド・ジエイ・グランポブニク
イン・スン
ドン・リウ
ヨンホワ・ガイ
ヤツト・スン・オア
シーベル・エイチ・ワゴー
ケン・エングストローム
テイム・グリーム
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Abbott Laboratories
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Abbott Laboratories
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Publication of JP2010065035A5 publication Critical patent/JP2010065035A5/ja
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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2009208935A 2008-09-11 2009-09-10 大環状ｃ型肝炎セリンプロテアーゼ阻害薬 Expired - Fee Related JP5259537B2 (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US19172508P 2008-09-11 2008-09-11
US61/191,725 2008-09-11
US20968909P 2009-03-10 2009-03-10
US61/209,689 2009-03-10

Related Child Applications (1)

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JP2012046166A Division JP5534533B2 (ja) 2008-09-11 2012-03-02 大環状ｃ型肝炎セリンプロテアーゼ阻害薬

Publications (3)

Publication Number Publication Date
JP2010065035A JP2010065035A (ja) 2010-03-25
JP2010065035A5 JP2010065035A5 (enExample) 2011-08-04
JP5259537B2 true JP5259537B2 (ja) 2013-08-07

Family

ID=42005677

Family Applications (4)

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JP2009208935A Expired - Fee Related JP5259537B2 (ja) 2008-09-11 2009-09-10 大環状ｃ型肝炎セリンプロテアーゼ阻害薬
JP2012046166A Expired - Fee Related JP5534533B2 (ja) 2008-09-11 2012-03-02 大環状ｃ型肝炎セリンプロテアーゼ阻害薬
JP2013092319A Expired - Fee Related JP5902123B2 (ja) 2008-09-11 2013-04-25 大環状ｃ型肝炎セリンプロテアーゼ阻害薬
JP2013092318A Expired - Fee Related JP5801342B2 (ja) 2008-09-11 2013-04-25 大環状ｃ型肝炎セリンプロテアーゼ阻害薬

Family Applications After (3)

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JP2012046166A Expired - Fee Related JP5534533B2 (ja) 2008-09-11 2012-03-02 大環状ｃ型肝炎セリンプロテアーゼ阻害薬
JP2013092319A Expired - Fee Related JP5902123B2 (ja) 2008-09-11 2013-04-25 大環状ｃ型肝炎セリンプロテアーゼ阻害薬
JP2013092318A Expired - Fee Related JP5801342B2 (ja) 2008-09-11 2013-04-25 大環状ｃ型肝炎セリンプロテアーゼ阻害薬

Country Status (41)

Country Link
US (3) US8420596B2 (enExample)
EP (5) EP2468287B1 (enExample)
JP (4) JP5259537B2 (enExample)
KR (3) KR101379365B1 (enExample)
CN (3) CN103896950A (enExample)
AR (3) AR073568A1 (enExample)
AU (1) AU2009292182B2 (enExample)
BR (2) BR122012005261A8 (enExample)
CA (1) CA2736895C (enExample)
CL (2) CL2011000512A1 (enExample)
CO (1) CO6341565A2 (enExample)
CR (1) CR20140180A (enExample)
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DK (5) DK2805726T3 (enExample)
DO (1) DOP2011000077A (enExample)
EA (2) EA022891B1 (enExample)
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LU (1) LU92667I2 (enExample)
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MY (1) MY159820A (enExample)
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PE (3) PE20140961A1 (enExample)
PL (5) PL2805726T3 (enExample)
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TR (1) TR201809771T4 (enExample)
TW (3) TWI429449B (enExample)
UY (3) UY32099A (enExample)
WO (1) WO2010030359A2 (enExample)
ZA (2) ZA201101558B (enExample)

Cited By (2)

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JP2012136546A (ja) * 2008-09-11 2012-07-19 Abbott Lab 大環状ｃ型肝炎セリンプロテアーゼ阻害薬
JP2013522208A (ja) * 2010-03-10 2013-06-13 アボット・ラボラトリーズ 固体組成物

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