CA2736895C - Macrocyclic hepatitis c serine protease inhibitors - Google Patents

Macrocyclic hepatitis c serine protease inhibitors Download PDF

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Publication number
CA2736895C
CA2736895C CA2736895A CA2736895A CA2736895C CA 2736895 C CA2736895 C CA 2736895C CA 2736895 A CA2736895 A CA 2736895A CA 2736895 A CA2736895 A CA 2736895A CA 2736895 C CA2736895 C CA 2736895C
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CA
Canada
Prior art keywords
optionally substituted
dioxo
yloxy
pyrrolo
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CA2736895A
Other languages
English (en)
French (fr)
Other versions
CA2736895A1 (en
Inventor
Yiyin Ku
Keith F. Mcdaniel
Hui-Ju Chen
Jason P. Shanley
Dale J. Kempf
David J. Grampovnik
Ying Sun
Dong Liu
Yonghua Gai
Yat Sun Or
Sable H. Wagaw
Ken Engstrom
Tim Grieme
Ahmad Sheikh
Jianzhang Mei
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AbbVie Ireland ULC
Enanta Pharmaceuticals Inc
Original Assignee
AbbVie Bahamas Ltd
Enanta Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42005677&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CA2736895(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by AbbVie Bahamas Ltd, Enanta Pharmaceuticals Inc filed Critical AbbVie Bahamas Ltd
Publication of CA2736895A1 publication Critical patent/CA2736895A1/en
Application granted granted Critical
Publication of CA2736895C publication Critical patent/CA2736895C/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
    • C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA2736895A 2008-09-11 2009-09-10 Macrocyclic hepatitis c serine protease inhibitors Active CA2736895C (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US19172508P 2008-09-11 2008-09-11
US61/191,725 2008-09-11
US20968909P 2009-03-10 2009-03-10
US61/209,689 2009-03-10
PCT/US2009/005082 WO2010030359A2 (en) 2008-09-11 2009-09-10 Macrocyclic hepatitis c serine protease inhibitors

Publications (2)

Publication Number Publication Date
CA2736895A1 CA2736895A1 (en) 2010-03-18
CA2736895C true CA2736895C (en) 2016-02-09

Family

ID=42005677

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2736895A Active CA2736895C (en) 2008-09-11 2009-09-10 Macrocyclic hepatitis c serine protease inhibitors

Country Status (41)

Country Link
US (3) US8420596B2 (enExample)
EP (5) EP2468287B1 (enExample)
JP (4) JP5259537B2 (enExample)
KR (3) KR101379365B1 (enExample)
CN (3) CN102641271B (enExample)
AR (3) AR073568A1 (enExample)
AU (1) AU2009292182B2 (enExample)
BR (2) BR122012005261A8 (enExample)
CA (1) CA2736895C (enExample)
CL (2) CL2011000512A1 (enExample)
CO (1) CO6341565A2 (enExample)
CR (1) CR20140180A (enExample)
CY (6) CY1115137T1 (enExample)
DK (5) DK2468287T3 (enExample)
DO (1) DOP2011000077A (enExample)
EA (2) EA020580B1 (enExample)
EC (2) ECSP11010879A (enExample)
ES (5) ES2677644T3 (enExample)
GT (2) GT201100056AA (enExample)
HR (5) HRP20140494T1 (enExample)
HU (2) HUE039478T2 (enExample)
IL (2) IL218441A (enExample)
LT (2) LT2805726T (enExample)
LU (1) LU92667I2 (enExample)
MX (1) MX2011002486A (enExample)
MY (1) MY159820A (enExample)
NL (1) NL300730I2 (enExample)
NO (1) NO2015014I1 (enExample)
NZ (2) NZ592170A (enExample)
PA (1) PA8842201A1 (enExample)
PE (3) PE20121312A1 (enExample)
PL (5) PL2340029T3 (enExample)
PT (5) PT2468286E (enExample)
SG (1) SG179414A1 (enExample)
SI (5) SI2468286T1 (enExample)
SM (1) SMT201800407T1 (enExample)
TR (1) TR201809771T4 (enExample)
TW (3) TWI510245B (enExample)
UY (3) UY32099A (enExample)
WO (1) WO2010030359A2 (enExample)
ZA (2) ZA201101558B (enExample)

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