JP5244103B2 - 器官特異的蛋白質およびその使用方法 - Google Patents
器官特異的蛋白質およびその使用方法 Download PDFInfo
- Publication number
- JP5244103B2 JP5244103B2 JP2009523868A JP2009523868A JP5244103B2 JP 5244103 B2 JP5244103 B2 JP 5244103B2 JP 2009523868 A JP2009523868 A JP 2009523868A JP 2009523868 A JP2009523868 A JP 2009523868A JP 5244103 B2 JP5244103 B2 JP 5244103B2
- Authority
- JP
- Japan
- Prior art keywords
- organ
- protein
- specific
- detected
- proteins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
- G01N33/6845—Methods of identifying protein-protein interactions in protein mixtures
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US83698606P | 2006-08-09 | 2006-08-09 | |
| US60/836,986 | 2006-08-09 | ||
| PCT/US2007/017868 WO2008021290A2 (en) | 2006-08-09 | 2007-08-09 | Organ-specific proteins and methods of their use |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010500568A JP2010500568A (ja) | 2010-01-07 |
| JP2010500568A5 JP2010500568A5 (cg-RX-API-DMAC7.html) | 2012-03-08 |
| JP5244103B2 true JP5244103B2 (ja) | 2013-07-24 |
Family
ID=39082660
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009523868A Expired - Fee Related JP5244103B2 (ja) | 2006-08-09 | 2007-08-09 | 器官特異的蛋白質およびその使用方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8586006B2 (cg-RX-API-DMAC7.html) |
| EP (2) | EP2057465A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5244103B2 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2007284651B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2660286A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2008021290A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (365)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10254601A1 (de) | 2002-11-22 | 2004-06-03 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| DE102004024617A1 (de) | 2004-05-18 | 2005-12-29 | Ganymed Pharmaceuticals Ag | Differentiell in Tumoren exprimierte Genprodukte und deren Verwendung |
| WO2006063462A1 (en) | 2004-12-13 | 2006-06-22 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in the process of bone remodeling |
| US8044179B2 (en) | 2005-09-13 | 2011-10-25 | National Research Council Of Canada | Methods and compositions for modulating tumor cell activity |
| EP1790664A1 (en) | 2005-11-24 | 2007-05-30 | Ganymed Pharmaceuticals AG | Monoclonal antibodies against claudin-18 for treatment of cancer |
| US8168181B2 (en) | 2006-02-13 | 2012-05-01 | Alethia Biotherapeutics, Inc. | Methods of impairing osteoclast differentiation using antibodies that bind siglec-15 |
| EP2438962A3 (en) | 2006-02-13 | 2012-07-18 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in the process of bone remodeling |
| US20120128661A1 (en) * | 2006-06-23 | 2012-05-24 | Alethia Biotherapeutics Inc. | Polynucleotide and polypeptide sequences involved in cancer |
| EP2502628B1 (en) | 2006-06-23 | 2016-12-14 | Alethia Biotherapeutics Inc. | Polynucleotides and polypeptide sequences involved in cancer |
| AU2007284651B2 (en) * | 2006-08-09 | 2014-03-20 | Institute For Systems Biology | Organ-specific proteins and methods of their use |
| WO2008026010A1 (en) | 2006-08-29 | 2008-03-06 | Oxford Genome Sciences (Uk) Ltd | Identification of protein associated with hepatocellular carcinoma, glioblastoma and lung cancer |
| WO2008057795A2 (en) * | 2006-10-27 | 2008-05-15 | Temple University - Of The Commonwealth System Of Higher Education | Novel tumor antigens elicit anti-tumor humoral immune reactions in a subset of patients with polycythemia vera |
| WO2008054764A2 (en) * | 2006-10-31 | 2008-05-08 | George Mason Intellectual Properties, Inc. | Biomarkers for colorectal cancer |
| JP4866467B2 (ja) | 2007-01-30 | 2012-02-01 | エピバックス インコーポレーテッド | 調節性t細胞エピトープ、組成物およびその使用 |
| WO2008104803A2 (en) | 2007-02-26 | 2008-09-04 | Oxford Genome Sciences (Uk) Limited | Proteins |
| US20090062144A1 (en) * | 2007-04-03 | 2009-03-05 | Nancy Lan Guo | Gene signature for prognosis and diagnosis of lung cancer |
| WO2008128161A2 (en) * | 2007-04-13 | 2008-10-23 | University Of Florida Research Foundation Inc. | Identification of cardiac specific myosin light chain kinase |
| JP2010529843A (ja) * | 2007-06-03 | 2010-09-02 | オンコティーエックス インコーポレイテッド | バイオマーカーおよび薬物標的としての、転写因子複合体の構成要素のがん関連アイソフォーム |
| FR2919064B1 (fr) | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de l'apolipoproteine all pour le diagnostic in vitro du cancer colorectal |
| FR2919062B1 (fr) | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de l'aminoacylase 1 pour le diagnostic in vitro du cancer colorectal. |
| FR2919060B1 (fr) | 2007-07-19 | 2012-11-30 | Biomerieux Sa | Procede de dosage de l'ezrine pour le diagnostic in vitro du cancer colorectal. |
| ES2565512T3 (es) | 2007-07-19 | 2016-04-05 | bioMérieux | Procedimiento de ensayo de la proteína de unión a ácidos grasos del hígado, de ACE y de CA19-9 para el diagnóstico in vitro del cáncer colorrectal |
| FR2919061B1 (fr) | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de la plastine-i pour le diagnostic in vitro du cancer colorectal. |
| FR2919065B1 (fr) | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage de l'apolipoproteine ai pour le diagnostic in vitro du cancer colorectal |
| FR2919063B1 (fr) | 2007-07-19 | 2009-10-02 | Biomerieux Sa | Procede de dosage du leucocyte elastase inhibitor pour le diagnostic in vitro du cancer colorectal. |
| US10247736B2 (en) * | 2007-07-20 | 2019-04-02 | Brigham Young University | Identification and quantification of biomarkers for evaluating the risk of preterm birth |
| DE102007036678B4 (de) * | 2007-08-03 | 2015-05-21 | Sirs-Lab Gmbh | Verwendung von Polynukleotiden zur Erfassung von Genaktivitäten für die Unterscheidung zwischen lokaler und systemischer Infektion |
| US7858759B2 (en) * | 2007-10-04 | 2010-12-28 | Zymogenetics, Inc. | Anti-zB7H6 antibody-drug conjugates |
| ES2505440T3 (es) * | 2007-10-19 | 2014-10-09 | Rappaport Family Institute For Research In The Medical Sciences | Composiciones que comprenden semaforinas para el tratamiento de las enfermedades relacionadas con la angiogénesis y los procedimientos de selección de las mismas |
| US9808506B2 (en) | 2007-10-19 | 2017-11-07 | Rappaport Family Institute For Research In The Medical Sciences | Compositions comprising semaphorins for the treatment of cancer and methods of selection thereof |
| AU2008316317B2 (en) * | 2007-10-23 | 2015-04-30 | Clinical Genomics Pty. Ltd. | A method of diagnosing neoplasms |
| US9404932B2 (en) * | 2007-11-05 | 2016-08-02 | Nordic Bioscience A/S | Pathology biomarker assay |
| RU2486200C2 (ru) * | 2008-01-14 | 2013-06-27 | Дженентек, Инк. | Способы ингибирования ангиогенеза с помощью антагонистов egfl8 |
| US8470977B2 (en) | 2008-03-14 | 2013-06-25 | Transgene S.A. | Antibody against the CSF-1R |
| NZ587830A (en) | 2008-03-14 | 2012-08-31 | Transgene Sa | Antibody against the colony-stimulating factor-1 receptor (CSF-1R) |
| EP2279414A4 (en) * | 2008-04-21 | 2011-06-29 | Merck Sharp & Dohme | PANCREATIC BETA CELL MASSE BIOMARKERS |
| US8173369B2 (en) * | 2008-05-15 | 2012-05-08 | The Regents Of The University Of California | Peripheral gene expression biomarkers for autism |
| JP5428527B2 (ja) * | 2008-06-03 | 2014-02-26 | 住友化学株式会社 | 化学物質が有する発生毒性の予測方法 |
| FR2933773B1 (fr) * | 2008-07-10 | 2013-02-15 | Biomerieux Sa | Procede de dosage de la proteine disulfide isomerase pour le diagnostic in vitro du cancer colorectal |
| EP2310861B1 (en) * | 2008-07-31 | 2015-01-07 | Queen Mary And Westfield College, University Of London | Healthy kidney biomarkers |
| EP2161031A1 (en) * | 2008-09-05 | 2010-03-10 | SuppreMol GmbH | Fc gamma receptor for the treatment of B cell mediated multiple sclerosis |
| US9855291B2 (en) | 2008-11-03 | 2018-01-02 | Adc Therapeutics Sa | Anti-kidney associated antigen 1 (KAAG1) antibodies |
| DK2391653T3 (en) | 2009-01-28 | 2015-02-09 | Ind Tech Res Inst | Biomarkers associated nephropathy |
| DK2623517T3 (en) | 2009-01-28 | 2015-11-23 | Ind Tech Res Inst | Urine and serum biomarkers associated with diabetic nephropathy |
| EP2524928A1 (en) * | 2011-05-18 | 2012-11-21 | Atlas Antibodies AB | RBM3 in bladder cancer |
| EP2221066A1 (en) | 2009-02-18 | 2010-08-25 | Sanofi-Aventis | Use of VgII3 activity modulator for the modulation of adipogenesis |
| EP2403864B1 (en) | 2009-02-27 | 2015-08-12 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
| PL2403878T3 (pl) | 2009-03-05 | 2017-12-29 | E. R. Squibb & Sons, L.L.C. | W pełni ludzkie przeciwciała specyficzne dla CADM1 |
| GB0904382D0 (en) * | 2009-03-13 | 2009-04-29 | Univ Dundee | Treatment of cell proliferation and differentiation disorders |
| ES2742251T3 (es) | 2009-03-16 | 2020-02-13 | Pangu Biopharma Ltd | Composiciones y procedimientos que comprenden variantes de splicing de histidil-tarn sintetasa que tienen actividades biológicas no canónicas |
| WO2010120509A2 (en) | 2009-03-31 | 2010-10-21 | Atyr Pharma, Inc. | Compositions and methods comprising aspartyl-trna synthetases having non-canonical biological activities |
| US8399663B2 (en) | 2009-04-03 | 2013-03-19 | Astellas Pharma Inc. | Salt of 1,3,5-triazine-2,4,6-triamine derivative |
| CA2756927A1 (en) * | 2009-04-09 | 2010-10-14 | Centre For Addiction And Mental Health | Dopamine d2 receptor-disc1 interaction, compositions and methods for modulating same |
| CA2763918A1 (en) | 2009-06-05 | 2010-12-09 | The University Of North Carolina At Chapel Hill | Soga polynucleotides and polypeptides and uses thereof |
| CA2767616A1 (en) | 2009-07-09 | 2011-01-13 | The Scripps Research Institute | Gene expression profiles associated with chronic allograft nephropathy |
| US9796761B2 (en) * | 2009-07-14 | 2017-10-24 | National Institute Of Advanced Industrial Science And Technology | Glycan markers as measure of disease state of hepatic diseases |
| WO2011009218A1 (en) * | 2009-07-24 | 2011-01-27 | Université de Montréal | Raf dimers and uses thereof |
| US9410965B2 (en) * | 2009-09-17 | 2016-08-09 | Battelle Energy Alliance, Llc | Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual |
| EP2483690A1 (de) * | 2009-09-29 | 2012-08-08 | Protagen AG | Markersequenzen für pankreaskrebserkrankungen, pankreaskarzinom und deren verwendung |
| JP5695383B2 (ja) | 2009-10-05 | 2015-04-01 | 花王株式会社 | 毛髪形状感受性遺伝子 |
| JP5695385B2 (ja) | 2009-10-05 | 2015-04-01 | 花王株式会社 | 毛髪形状感受性遺伝子 |
| JP5695384B2 (ja) | 2009-10-05 | 2015-04-01 | 花王株式会社 | 毛髪形状感受性遺伝子 |
| EP2494361B2 (en) | 2009-10-26 | 2019-01-09 | Externautics S.p.A. | Ovary tumor markers and methods of use thereof |
| WO2011051271A2 (en) * | 2009-10-26 | 2011-05-05 | Externautics S.P.A. | Prostate tumor markers and methods of use thereof |
| US9588121B2 (en) | 2009-11-06 | 2017-03-07 | Go Therapeutics, Inc. | Method for early detection of cancer |
| EA034462B1 (ru) | 2009-11-24 | 2020-02-11 | Алетиа Байотерапьютикс Инк. | Антикластериновые антитела и антигенсвязывающие фрагменты и их использование для уменьшения объема новообразований |
| SG10201408598XA (en) | 2009-11-30 | 2015-02-27 | Genentech Inc | Antibodies for treating and diagnosing tumors expressing slc34a2 (tat211 = seqid2 ) |
| WO2011067624A1 (en) * | 2009-12-01 | 2011-06-09 | Universita' Degli Studi Di Modena E Reggio Emilia | Peptides binding to the dimer interface of thymidylate synthase for the treatment of cancer |
| US9127268B2 (en) | 2009-12-11 | 2015-09-08 | Atyr Pharma, Inc. | Aminoacyl tRNA synthetases for modulating inflammation |
| US8835358B2 (en) | 2009-12-15 | 2014-09-16 | Cellular Research, Inc. | Digital counting of individual molecules by stochastic attachment of diverse labels |
| US9624547B2 (en) | 2010-02-10 | 2017-04-18 | The Regents Of The University Of California | Salivary transcriptomic and proteomic biomarkers for breast cancer detection |
| CN103037900B (zh) | 2010-02-24 | 2016-04-06 | 伊缪诺金公司 | 叶酸受体1抗体与免疫缀合物以及其用途 |
| WO2011115225A1 (ja) * | 2010-03-17 | 2011-09-22 | 国立大学法人 鹿児島大学 | 歯周病特異的ペプチド、並びにそれを用いた歯周病の治療および診断 |
| SG184345A1 (en) * | 2010-03-31 | 2012-11-29 | Agency Science Tech & Res | Amphiphilic linear peptide/peptoid and hydrogel comprising the same |
| AU2011248625B2 (en) | 2010-04-26 | 2017-01-05 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
| ES2638311T3 (es) | 2010-04-27 | 2017-10-19 | Atyr Pharma, Inc. | Descubrimiento innovador de composiciones terapéuticas, diagnósticas y de anticuerpos relacionadas con fragmentos de proteína de treonil ARNt sintetasas |
| WO2011139799A2 (en) | 2010-04-27 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of isoleucyl trna synthetases |
| WO2011139853A2 (en) | 2010-04-28 | 2011-11-10 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of alanyl trna synthetases |
| US8986680B2 (en) | 2010-04-29 | 2015-03-24 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Asparaginyl tRNA synthetases |
| JP5991963B2 (ja) | 2010-04-29 | 2016-09-14 | エータイアー ファーマ, インコーポレイテッド | バリルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| CA2797277C (en) | 2010-05-03 | 2021-02-23 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of arginyl-trna synthetases |
| US9034321B2 (en) | 2010-05-03 | 2015-05-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases |
| JP6039546B2 (ja) | 2010-05-03 | 2016-12-07 | エータイアー ファーマ, インコーポレイテッド | セリルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| US8759298B2 (en) | 2010-05-03 | 2014-06-24 | Scott & White Healthcare | Protein therapy for corneal inflammation, epithelial wound healing, and photoreceptor degeneration |
| US8981045B2 (en) | 2010-05-03 | 2015-03-17 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of methionyl-tRNA synthetases |
| WO2011139387A1 (en) * | 2010-05-03 | 2011-11-10 | Opko Curna, Llc | Treatment of sirtuin (sirt) related diseases by inhibition of natural antisense transcript to a sirtuin (sirt) |
| JP6008844B2 (ja) | 2010-05-04 | 2016-10-19 | エータイアー ファーマ, インコーポレイテッド | p38MULTI−tRNA合成酵素複合体のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
| EP2566492B1 (en) | 2010-05-04 | 2016-10-26 | aTyr Pharma, Inc. | Innovative discovery of therapeutic compositions related to protein fragments of glutamyl-prolyl-trna synthetases |
| AU2011252990B2 (en) | 2010-05-14 | 2017-04-20 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases |
| AU2011256366C1 (en) | 2010-05-17 | 2017-06-15 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of leucyl-tRNA synthetases |
| GB201008541D0 (en) * | 2010-05-21 | 2010-07-07 | Univ Geneve | Diagnostic methods |
| CN103096913B (zh) | 2010-05-27 | 2017-07-18 | Atyr 医药公司 | 与谷氨酰胺酰‑tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
| DK2577316T3 (en) | 2010-05-31 | 2017-05-08 | Univ Hospital Of Basel | Procedure for testing for lower respiratory tract infections or inflammation |
| AU2011261486B2 (en) | 2010-06-01 | 2017-02-23 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of lysyl-tRNA synthetases |
| CA3155662C (en) | 2010-06-03 | 2023-05-16 | Idexx Laboratories, Inc. | Markers for renal disease |
| AU2015230872B2 (en) * | 2010-06-03 | 2017-05-11 | Idexx Laboratories, Inc. | Markers for renal disease |
| CN103118695B (zh) | 2010-07-12 | 2016-08-03 | Atyr医药公司 | 与甘氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的发现 |
| US20130202576A1 (en) | 2010-07-12 | 2013-08-08 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of histidyl-trna synthetases |
| US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
| WO2012009289A2 (en) | 2010-07-12 | 2012-01-19 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of aspartyl-trna synthetases |
| JP6603009B2 (ja) | 2010-08-13 | 2019-11-06 | アリゾナ ボード オブ リージェンツ ア ボディー コーポレート アクティング オン ビハーフ オブ アリゾナ ステイト ユニバーシティ | 乳がんの検出を補助する方法、並びに乳がん検出用のポリペプチドプローブセット |
| JP6021151B2 (ja) * | 2010-08-16 | 2016-11-09 | 国立大学法人九州大学 | 腫瘍の検査用試薬及び腫瘍の予防用医薬組成物 |
| CA2808539C (en) | 2010-08-25 | 2021-05-25 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tyrosyl-trna synthetases |
| US9552973B2 (en) * | 2010-09-02 | 2017-01-24 | University Of The Sciences In Philadelphia | System and method for ionization of molecules for mass spectrometry and ion mobility spectrometry |
| WO2012035066A1 (en) * | 2010-09-14 | 2012-03-22 | Max-Planck-Gesellschaft Zur Förderung Der Wissenschften E.V. | Hot1 and uses thereof |
| WO2012038503A1 (en) * | 2010-09-23 | 2012-03-29 | Qiagen Gmbh | Method for detecting and/or quantifying human dna |
| ES2645019T3 (es) | 2010-10-06 | 2017-12-01 | Atyr Pharma, Inc. | Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de triptofanil-ARNt sintetasas |
| FR2968560A1 (fr) * | 2010-12-13 | 2012-06-15 | Oreal | Utilisation de l'ide comme biomarqueur d'un etat du cuir chevelu |
| JP2014503222A (ja) | 2011-01-18 | 2014-02-13 | エバリスト ジェノミックス, インコーポレイテッド | 結腸直腸がん再発に関する予後のサイン |
| US9364414B2 (en) | 2011-02-01 | 2016-06-14 | Isp Investments Inc. | Method to protect skin from ultraviolet radiation using novel peptides involved in the improvement of microparasol organization in keratinocytes |
| FR2970968A1 (fr) * | 2011-02-01 | 2012-08-03 | Isp Investments Inc | Nouveaux peptides intervenant dans la voie de signalisation scf c-kit et compositions les comprenant |
| US9157125B2 (en) | 2011-02-02 | 2015-10-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | GRIN2A mutations and use thereof for the diagnosis of melanoma |
| WO2012118988A1 (en) * | 2011-03-01 | 2012-09-07 | The Scripps Research Institute | Direct reprogramming of human fibroblasts to functional neurons under defined conditions |
| JP2012197258A (ja) * | 2011-03-23 | 2012-10-18 | Tohoku Univ | 個別化治療診断のためのマーカータンパク質絶対量の定量方法 |
| US20140113297A1 (en) * | 2011-03-26 | 2014-04-24 | Oregon Health & Science University | Gene expression predictors of cancer prognosis |
| JP5800180B2 (ja) * | 2011-03-28 | 2015-10-28 | 国立大学法人 長崎大学 | 日焼けの原因遺伝子 |
| SMT201900505T1 (it) | 2011-03-31 | 2019-11-13 | Adc Therapeutics Sa | Anticorpi contro l'antigene 1 associato ai reni e loro frammenti leganti l'antigene |
| CA2831426C (en) | 2011-04-01 | 2023-02-21 | Immunogen, Inc. | Methods for increasing efficacy of folr1 cancer therapy |
| CA2832115C (en) | 2011-04-08 | 2021-03-02 | Tufts Medical Center, Inc. | Pepducin design and use |
| SG194099A1 (en) * | 2011-04-15 | 2013-11-29 | Compugen Ltd | Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer |
| CN106053835A (zh) * | 2011-04-15 | 2016-10-26 | 儿童医疗中心有限公司 | 川崎病的诊断标志物和治疗靶点 |
| WO2012149481A1 (en) * | 2011-04-27 | 2012-11-01 | The Board Of Regents On The University Of Texas System | Novel peptide inhibitors of serotonin 5-ht2c receptor:pten interaction |
| WO2012156665A2 (en) * | 2011-05-13 | 2012-11-22 | King's College London | Methods and compositions relating to platelet sensitivity |
| WO2012166626A1 (en) * | 2011-05-27 | 2012-12-06 | University Of Washington Through Its Center For Commercialization | Reagents and methods for treating dental disease |
| EP2715367A2 (en) * | 2011-06-03 | 2014-04-09 | University of South Alabama | Methods and compositions for detecting endometrial or ovarian cancer |
| CN103842503A (zh) * | 2011-07-26 | 2014-06-04 | 独立行政法人产业技术综合研究所 | 上皮性卵巢癌标志物检测用抗体和上皮性卵巢癌判定方法 |
| WO2013022982A2 (en) | 2011-08-09 | 2013-02-14 | Atyr Pharma, Inc. | Pegylated tyrosyl-trna synthetase polypeptides |
| WO2013059740A1 (en) | 2011-10-21 | 2013-04-25 | Foundation Medicine, Inc. | Novel alk and ntrk1 fusion molecules and uses thereof |
| CN102337285A (zh) * | 2011-10-25 | 2012-02-01 | 上海交通大学医学院附属仁济医院 | 一种含HIhh的逆转录病毒载体和病毒颗粒及其应用 |
| KR20140092905A (ko) * | 2011-11-15 | 2014-07-24 | 온코사이트 코포레이션 | 방광암의 치료 및 진단을 위한 방법 및 조성물 |
| WO2013086216A1 (en) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Improved aspartyl-trna synthetases |
| US9822353B2 (en) | 2011-12-06 | 2017-11-21 | Atyr Pharma, Inc. | PEGylated aspartyl-tRNA synthetase polypeptides |
| US9187529B2 (en) * | 2011-12-21 | 2015-11-17 | Regents Of The University Of Minnesota | Cationic peptides and use of such peptides for inhibiting exotoxin production |
| CA2858613A1 (en) | 2011-12-29 | 2013-08-08 | Atyr Pharma, Inc. | Aspartyl-trna synthetase-fc conjugates |
| CA2857400A1 (en) | 2012-01-09 | 2013-07-18 | Alethia Biotherapeutics Inc. | Anti-kaag1 antibodies or antigen binding fragment thereof for treatment of triple negative breast cancer |
| CN105585629B (zh) * | 2012-01-16 | 2019-12-06 | 狮王株式会社 | 代谢综合征患病风险判定用标记肽及其用途 |
| DE102012100781B4 (de) | 2012-01-31 | 2013-08-14 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Forensisches Verfahren |
| AU2013221317B2 (en) | 2012-02-16 | 2017-07-06 | Pangu Biopharma Limited | Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases |
| US9345755B2 (en) * | 2012-02-20 | 2016-05-24 | University Of Virginia Patent Foundation | Composition and methods for treating melanoma |
| JP2015512877A (ja) | 2012-02-22 | 2015-04-30 | アレシア・バイオセラピューティクス・インコーポレーテッド | 癌を治療するためのクラステリン阻害剤とegfr阻害剤の併用 |
| US10941396B2 (en) | 2012-02-27 | 2021-03-09 | Becton, Dickinson And Company | Compositions and kits for molecular counting |
| WO2013135836A1 (en) * | 2012-03-14 | 2013-09-19 | Centre Hospitalier Universitaire Pontchaillou | Itih5 as a diagnostic marker of uterine development and functional defects |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| WO2013151663A1 (en) * | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of membrane proteins |
| WO2013155567A1 (en) * | 2012-04-20 | 2013-10-24 | Mat Malta Advanced Technologies Limited | Sex determination genes |
| WO2013167153A1 (en) | 2012-05-09 | 2013-11-14 | Ganymed Pharmaceuticals Ag | Antibodies useful in cancer diagnosis |
| EP2850229A4 (en) | 2012-05-16 | 2016-02-17 | Expression Pathology Inc | SRM / MRM METHOD FOR HISTOLOGICAL SUBTYPING OF PULMONARY TUMORS |
| ES2791251T3 (es) * | 2012-05-21 | 2020-11-03 | Univ Colorado Regents | Péptidos de Ledgf y formulaciones de los mismos para el tratamiento de trastornos degenerativos |
| US20150141340A1 (en) * | 2012-06-04 | 2015-05-21 | Yale University | Method of treating and preventing ocular angiogenesis |
| WO2013184912A2 (en) * | 2012-06-06 | 2013-12-12 | Oncomed Pharmaceuticals, Inc. | Binding agents that modulate the hippo pathway and uses thereof |
| EA201492284A1 (ru) | 2012-06-27 | 2015-11-30 | Берг Ллк | Применение маркеров в диагностике и лечении рака предстательной железы |
| NZ629538A (en) * | 2012-06-28 | 2016-10-28 | Caldera Health Ltd | Targeted rna-seq methods and materials for the diagnosis of prostate cancer |
| EP2875051B1 (en) | 2012-07-19 | 2019-02-20 | Daiichi Sankyo Company, Limited | Anti-siglec-15 antibodies |
| DK3489261T3 (da) | 2012-08-24 | 2020-12-14 | Univ California | Antistoffer og vacciner til anvendelse ved behandling af ror1-cancere og hæmning af metastase |
| CN104755498B (zh) | 2012-08-31 | 2019-06-18 | 伊缪诺金公司 | 用于检测叶酸受体1的诊断测定和试剂盒 |
| US9120841B2 (en) | 2012-09-28 | 2015-09-01 | Agency For Science, Technology And Research | Amphiphilic linear peptidepeptoid and hydrogel comprising the same |
| US9701714B2 (en) * | 2012-10-22 | 2017-07-11 | University Of Virginia Patent Foundation | Compositions and methods for regulating arterial tone |
| US11230589B2 (en) | 2012-11-05 | 2022-01-25 | Foundation Medicine, Inc. | Fusion molecules and uses thereof |
| EP2914621B1 (en) | 2012-11-05 | 2023-06-07 | Foundation Medicine, Inc. | Novel ntrk1 fusion molecules and uses thereof |
| EP2918600B1 (en) * | 2012-11-06 | 2019-04-24 | University of Miyazaki | Novel peptide and use thereof |
| JP6196034B2 (ja) * | 2012-12-20 | 2017-09-13 | ライオン株式会社 | 高血糖リスク判定用マーカーペプチドおよびその用途 |
| EP2934586A4 (en) * | 2012-12-21 | 2016-05-25 | Univ California | TSPAN 33 AS A CANDIDATE FOR ANTIBODY-TREATED THERAPY FOR THE TREATMENT OF B-CELL HODGKIN LYMPHOMES |
| SG2012096699A (en) * | 2012-12-31 | 2014-07-30 | Agency Science Tech & Res | Amphiphilic linear peptide/peptoid and hydrogel comprising the same |
| US10980804B2 (en) | 2013-01-18 | 2021-04-20 | Foundation Medicine, Inc. | Methods of treating cholangiocarcinoma |
| EP2966087B1 (en) | 2013-03-08 | 2020-05-06 | Osaka University | Antibody against peptide encoded by exon-21 of periostin, and pharmaceutical composition for preventing or treating inflammation-associated diseases containing the same |
| CN105378075B (zh) | 2013-03-15 | 2022-04-05 | Atyr 医药公司 | 组氨酰-trna合成酶-fc缀合物 |
| US20160039877A1 (en) | 2013-03-15 | 2016-02-11 | Shenzhen Hightide Biopharmaceutical, Ltd. | Compositions and methods of using islet neogenesis peptides and analogs thereof |
| TWI522367B (zh) * | 2013-04-12 | 2016-02-21 | Univ Chang Gung | Urine biomarkers are used to predict bladder and kidney cancer |
| JP6498114B2 (ja) * | 2013-04-25 | 2019-04-10 | 国立大学法人 宮崎大学 | 成人t細胞白血病の診断方法および成人t細胞白血病の治療薬のスクリーニング方法 |
| WO2014186809A2 (en) * | 2013-05-17 | 2014-11-20 | The Translational Genomics Research Institute | A genetic test to predict patient response to bone morphogenetic protein in arthrodesis |
| CN103319571B (zh) * | 2013-05-30 | 2015-04-08 | 北京正旦国际科技有限责任公司 | 一种鼻咽癌放疗敏感性多肽标志物spg03及其elisa试剂盒 |
| CA2913512A1 (en) * | 2013-05-30 | 2014-12-04 | Memorial University Of Newfoundland | Methods and compositions for detecting progressive hearing loss |
| GB201310203D0 (en) * | 2013-06-07 | 2013-07-24 | Electrophoretics Ltd | Materials and methods relating to Alzheimer's disease |
| WO2014199780A1 (ja) | 2013-06-12 | 2014-12-18 | マルハニチロ株式会社 | ジペプチジルペプチダーゼiv(dppiv)阻害ペプチド化合物、それを含有する組成物、及びその製造方法 |
| US20160175351A1 (en) * | 2013-06-24 | 2016-06-23 | Duke University | Cancer treatment |
| US9797912B2 (en) | 2013-06-28 | 2017-10-24 | Newsouth Innovations Pty Limited | Diagnostic method for inflammatory bowel disease |
| EP3039158B1 (en) | 2013-08-28 | 2018-11-14 | Cellular Research, Inc. | Massively parallel single cell analysis |
| US9637547B2 (en) | 2013-08-30 | 2017-05-02 | Immunogen, Inc. | Monoclonal antibodies for detection of folate receptor 1 |
| US10119143B2 (en) | 2013-10-04 | 2018-11-06 | Alnylam Pharmaceuticals, Inc. | Compositions and methods for inhibiting expression of the ALAS1 gene |
| CU24320B1 (es) | 2013-10-11 | 2018-02-08 | Berlin Chemie Ag | Anticuerpos conjugados contra antígeno linfocitario 75 para el tratamiento del cáncer |
| ES2730429T3 (es) | 2013-10-18 | 2019-11-11 | Univ Do Minho | Composición peptídica y usos de la misma |
| IL229134A0 (en) * | 2013-10-29 | 2014-03-31 | Omrix Biopharmaceuticals Ltd | Compounds and methods for stabilizing thrombin activity |
| CN106029874B (zh) | 2013-12-16 | 2020-09-15 | 北卡罗来纳-查佩尔山大学 | 浆细胞样树突状细胞的耗竭 |
| EP3092252B1 (en) * | 2014-01-08 | 2019-09-18 | The U.S.A. as represented by the Secretary, Department of Health and Human Services | Antibody targeting cell surface deposited complement protein c3d and use thereof |
| CN103756984B (zh) * | 2014-02-18 | 2015-10-14 | 吉林大学 | 高活力谷胱甘肽过氧化物酶gpx2突变体及其制备方法 |
| WO2015144861A1 (en) * | 2014-03-26 | 2015-10-01 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Flattop (fltp) is a novel biomarker for beta cell maturation |
| US10041077B2 (en) | 2014-04-09 | 2018-08-07 | Dna2.0, Inc. | DNA vectors, transposons and transposases for eukaryotic genome modification |
| US10155008B2 (en) * | 2014-04-18 | 2018-12-18 | Yantai Jujie Bioengineering Limited Company | Use of 15 male fertility related proteins or combination thereof |
| WO2015171822A1 (en) | 2014-05-06 | 2015-11-12 | Genentech, Inc. | Production of heteromultimeric proteins using mammalian cells |
| US11104951B2 (en) | 2014-05-22 | 2021-08-31 | The Scripps Research Institute | Molecular signatures for distinguishing liver transplant rejections or injuries |
| US10443100B2 (en) | 2014-05-22 | 2019-10-15 | The Scripps Research Institute | Gene expression profiles associated with sub-clinical kidney transplant rejection |
| GB201409519D0 (en) * | 2014-05-29 | 2014-07-16 | Univ Leicester | Senescent cell biomarkers |
| CN106687123A (zh) * | 2014-06-05 | 2017-05-17 | 科罗拉多州大学评议会 | Map44多肽和基于天然抗体的构建体及其用途 |
| CN105879053A (zh) * | 2014-09-26 | 2016-08-24 | 北京大学 | Cmtm1-v5基因及其编码蛋白的应用 |
| WO2016054075A1 (en) * | 2014-09-29 | 2016-04-07 | University Of Rochester | U2af65 variants and uses thereof |
| WO2016054114A1 (en) | 2014-09-29 | 2016-04-07 | The Regents Of The University Of California | Compositions for expanding regulatory t cells (treg), and treating autoimmune and inflammatory diseases and conditions |
| CA2961520A1 (en) * | 2014-10-01 | 2016-04-07 | Centre For Addiction And Mental Health | Markers for mood disorders |
| ES2568702B1 (es) * | 2014-10-01 | 2017-02-13 | Servizo Galego De Saude (Sergas) | Método para el diagnóstico de artrosis |
| CN104225088A (zh) * | 2014-10-06 | 2014-12-24 | 李先强 | 治疗慢性肺心病的混合中药 |
| CN107428821B (zh) | 2014-12-08 | 2022-06-24 | 博格有限责任公司 | 包括细丝蛋白a的标志物在诊断和治疗前列腺癌中的用途 |
| CA2969659A1 (en) * | 2014-12-09 | 2016-06-16 | Sapporo Medical University | Tumor antigen peptide |
| CA3237043A1 (en) | 2014-12-12 | 2016-06-16 | Tufts University | Collagenase-derived peptides promote tissue regeneration and wound healing |
| LT3616706T (lt) | 2014-12-23 | 2022-02-10 | Immatics Biotechnologies Gmbh | Nauji peptidai ir peptidų deriniai, skirti naudoti imunoterapijai prieš hepatoceliulinę karcinomą (hck) ir kitų rūšių vėžį |
| GB201501017D0 (en) | 2014-12-23 | 2015-03-04 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against hepatocellular carcinoma (HCC) and other cancers |
| CN104673762B (zh) * | 2015-01-19 | 2017-10-20 | 江苏大学 | 抗泛素连接酶Nedd4‑1的特异性抗体及其应用 |
| US20180002692A1 (en) * | 2015-01-30 | 2018-01-04 | Anushree Chatterjee | Sequence Specific and Organism Specific Antimicrobials and Related Materials and Methods |
| CN105985423A (zh) * | 2015-01-30 | 2016-10-05 | 天津奥维亚生物技术有限公司 | 一种人c1qb多肽及其抗体制备方法 |
| US10302652B2 (en) * | 2015-02-17 | 2019-05-28 | Elena SANTONICO | Hybrid protein for the identification of neddylated substrates |
| PT3258951T (pt) | 2015-02-19 | 2020-08-18 | Compugen Ltd | Anticorpos anti-pvrig e métodos de utilização |
| DK3259597T3 (da) | 2015-02-19 | 2022-05-09 | Compugen Ltd | Pvrig-polypeptider og fremgangsmåder til behandling |
| US9727810B2 (en) | 2015-02-27 | 2017-08-08 | Cellular Research, Inc. | Spatially addressable molecular barcoding |
| ES2952959T3 (es) | 2015-03-27 | 2023-11-07 | Immatics Biotechnologies Gmbh | Nuevos péptidos y nuevas combinaciones de péptidos para el uso en la inmunoterapia contra diversos tumores (SEQ ID N.º 25 - MXRA5-003) |
| GB201505305D0 (en) | 2015-03-27 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel Peptides and combination of peptides for use in immunotherapy against various tumors |
| JP7508191B2 (ja) | 2015-03-30 | 2024-07-01 | ベクトン・ディキンソン・アンド・カンパニー | コンビナトリアルバーコーディングのための方法および組成物 |
| GB201505585D0 (en) | 2015-03-31 | 2015-05-13 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides and scaffolds for use in immunotherapy against renal cell carinoma (RCC) and other cancers |
| HK1249140A1 (zh) | 2015-04-03 | 2018-10-26 | Ionis Pharmaceuticals, Inc. | 用於调节tmprss6表达的化合物和方法 |
| WO2016172373A1 (en) | 2015-04-23 | 2016-10-27 | Cellular Research, Inc. | Methods and compositions for whole transcriptome amplification |
| GB201507030D0 (en) * | 2015-04-24 | 2015-06-10 | Immatics Biotechnologies Gmbh | Immunotherapy against lung cancers, in particular NSCLC |
| WO2016187250A1 (en) | 2015-05-19 | 2016-11-24 | La Jolla Institute For Allergy And Immunology | Human apob100 epitopes, methods and uses for modulating inflammatory responses, and treating adverse cardiovascular events, disease and atherosclerosis |
| WO2016196229A1 (en) | 2015-06-01 | 2016-12-08 | Cellular Research, Inc. | Methods for rna quantification |
| CN107771285A (zh) | 2015-06-08 | 2018-03-06 | 阿奎尔诊断有限公司 | 方法 |
| EP3304084B1 (en) | 2015-06-08 | 2022-03-23 | Arquer Diagnostics Limited | Methods and kits |
| WO2016210137A1 (en) | 2015-06-26 | 2016-12-29 | The Regents Of The University Of California | Antigenic peptides and uses thereof for diagnosing and treating autism |
| EP3115058A1 (fr) * | 2015-07-09 | 2017-01-11 | Institut Gustave Roussy | Peptides immunogenes de preprocalcitonine |
| MX2018001566A (es) | 2015-08-07 | 2019-04-25 | Imaginab Inc | Construcciones de union a antigeno para moleculas diana. |
| EP3130680A1 (en) | 2015-08-11 | 2017-02-15 | Universitat de Girona | Method for the detection, follow up and/or classification of intestinal diseases |
| CN112961213A (zh) * | 2015-08-12 | 2021-06-15 | 肿瘤疗法科学股份有限公司 | Depdc1衍生的肽和包含它们的疫苗 |
| WO2017031342A1 (en) * | 2015-08-20 | 2017-02-23 | Rhode Island Hospital | Circulating biomarker for brugada syndrome |
| JP6757924B2 (ja) * | 2015-08-24 | 2020-09-23 | 国立大学法人 東京大学 | オキシトシン感受性予測マーカー |
| KR102395450B1 (ko) | 2015-09-11 | 2022-05-09 | 셀룰러 리서치, 인크. | 핵산 라이브러리 정규화를 위한 방법 및 조성물 |
| IL257531B2 (en) | 2015-09-17 | 2023-04-01 | Immunogen Inc | Medicinal compositions containing anti-folr1 immunoconjugates |
| HUE056009T2 (hu) | 2015-10-08 | 2022-01-28 | Dna Twopointo Inc | DNS vektorok, transzpozonok és transzpozázok eukarióta genom módosítására |
| DK3359210T3 (da) * | 2015-10-08 | 2021-07-12 | Univ Geneve | Periostin-fragmenter og anvendelse deraf |
| US10844109B2 (en) | 2015-10-16 | 2020-11-24 | Institut National Transfusion Sanguine | Method for producing erythrocyte proteins |
| US11634470B2 (en) | 2015-10-23 | 2023-04-25 | Jai Prakash | Integrin binding peptides and uses thereof |
| EP3373950B1 (en) | 2015-11-11 | 2024-05-01 | Serimmune Inc. | Methods and compositions for assessing antibody specificities |
| EP3374386B1 (en) | 2015-11-13 | 2024-05-29 | Oasis Pharmaceuticals, LLC | Protease-activated receptor-2 modulators |
| CA3005633C (en) | 2015-11-16 | 2023-11-21 | Research Institute Of Nationwide Children's Hospital | Materials and methods for treatment of titin-based myopathies and other titinopathies |
| GB201520550D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201607534D0 (en) * | 2016-04-29 | 2016-06-15 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520542D0 (en) * | 2015-11-23 | 2016-01-06 | Immunocore Ltd & Adaptimmune Ltd | Peptides |
| GB201520568D0 (en) | 2015-11-23 | 2016-01-06 | Immunocore Ltd | Peptides |
| IL298653A (en) | 2015-12-11 | 2023-01-01 | Immatics Biotechnologies Gmbh | New peptides and a combination of peptides for use in immunotherapy against several types of cancer |
| GB201521894D0 (en) | 2015-12-11 | 2016-01-27 | Immatics Biotechnologies Gmbh | Novel peptides and combination of peptides for use in immunotherapy against various cancers |
| CN109072219B (zh) * | 2015-12-28 | 2024-02-27 | 北海道公立大学法人札幌医科大学 | 肿瘤抗原肽 |
| CN105622742B (zh) * | 2016-02-22 | 2019-01-18 | 西安交通大学 | 一种孤独症血清多肽标志物fabp1-a及其应用 |
| AR107786A1 (es) | 2016-03-02 | 2018-06-06 | Idexx Lab Inc | Métodos y composiciones para la detección y el diagnóstico de enfermedad renal y enfermedad periodontal |
| KR102411975B1 (ko) | 2016-04-06 | 2022-06-22 | 이매틱스 바이오테크놀로지스 게엠베하 | Aml 및 다른 암에 대한 면역요법에 사용하기 위한 펩티드 및 펩티드의 조합 |
| HRP20240580T1 (hr) | 2016-04-15 | 2024-07-19 | Research Institute At Nationwide Children's Hospital | ISPORUKA ADENO-POVEZANIM VIRUSNIM VEKTOROM β-SARKOGLIKANA I MIKRORNA-29 I LIJEČENJE MIŠIĆNE DISTROFIJE |
| EP3452614B1 (en) | 2016-05-02 | 2023-06-28 | Becton, Dickinson and Company | Accurate molecular barcoding |
| WO2017190218A1 (en) * | 2016-05-06 | 2017-11-09 | University Health Network | Liquid-biopsy signatures for prostate cancer |
| US10301677B2 (en) | 2016-05-25 | 2019-05-28 | Cellular Research, Inc. | Normalization of nucleic acid libraries |
| US10640763B2 (en) | 2016-05-31 | 2020-05-05 | Cellular Research, Inc. | Molecular indexing of internal sequences |
| US10202641B2 (en) | 2016-05-31 | 2019-02-12 | Cellular Research, Inc. | Error correction in amplification of samples |
| CA2971303A1 (en) | 2016-06-21 | 2017-12-21 | Bamboo Therapeutics, Inc. | Optimized mini-dystrophin genes and expression cassettes and their use |
| JP7109007B2 (ja) | 2016-06-27 | 2022-07-29 | ザ・リージエンツ・オブ・ザ・ユニバーシテイー・オブ・カリフオルニア | がん治療の組み合わせ |
| US20240002459A1 (en) * | 2016-07-14 | 2024-01-04 | Emory University | Granulin Compositions and Uses Related Thereto |
| CN110088132B (zh) | 2016-08-17 | 2020-10-27 | 康姆普根有限公司 | 抗tigit抗体,抗pvrig抗体及其组合 |
| TWI796299B (zh) | 2016-08-26 | 2023-03-21 | 德商英麥提克生物技術股份有限公司 | 用於頭頸鱗狀細胞癌和其他癌症免疫治療的新型肽和支架 |
| NZ751906A (en) | 2016-09-23 | 2025-10-31 | Regeneron Pharma | Anti-steap2 antibodies, antibody-drug conjugates, and bispecific antigen-binding molecules that bind steap2 and cd3, and uses thereof |
| EP3516400B1 (en) | 2016-09-26 | 2023-08-16 | Becton, Dickinson and Company | Measurement of protein expression using reagents with barcoded oligonucleotide sequences |
| EP3522909A4 (en) * | 2016-10-07 | 2020-07-08 | Board of Regents, The University of Texas System | HLA RESTRICTED VGLL1 PEPTIDES AND THEIR USE |
| US11981943B2 (en) | 2016-10-11 | 2024-05-14 | University Of Iowa Research Foundation | Methods and composition for detecting CAPN5 |
| WO2018120610A1 (zh) * | 2016-12-27 | 2018-07-05 | 浙江大学 | 一种Leg1蛋白、Leg1基因及其应用和药物 |
| US11319583B2 (en) | 2017-02-01 | 2022-05-03 | Becton, Dickinson And Company | Selective amplification using blocking oligonucleotides |
| WO2018147960A1 (en) | 2017-02-08 | 2018-08-16 | Imaginab, Inc. | Extension sequences for diabodies |
| WO2018183449A1 (en) * | 2017-03-31 | 2018-10-04 | Alexion Pharmaceuticals, Inc. | Method for simultaneous quantification of alxn1210 and eculizumab in human serum or urine |
| US11767520B2 (en) | 2017-04-20 | 2023-09-26 | Atyr Pharma, Inc. | Compositions and methods for treating lung inflammation |
| US11531030B2 (en) * | 2017-04-21 | 2022-12-20 | Mayo Foundation For Medical Education And Research | Polypeptide-antibody complexes and uses thereof |
| KR102606810B1 (ko) | 2017-05-05 | 2023-11-27 | 유니버시티 오브 플로리다 리서치 파운데이션, 인코포레이티드 | 오토펄린을 발현시키기 위한 조성물 및 방법 |
| CA3064331A1 (en) | 2017-06-01 | 2018-12-06 | Compugen Ltd. | Triple combination antibody therapies |
| JP7536450B2 (ja) | 2017-06-05 | 2024-08-20 | ベクトン・ディキンソン・アンド・カンパニー | 単一細胞用のサンプルインデックス付加 |
| US20200124605A1 (en) * | 2017-06-08 | 2020-04-23 | University Of Miyazaki | Method for detection of lung cancer |
| US12374423B2 (en) | 2017-06-27 | 2025-07-29 | The Broad Institute, Inc | Systems and methods for MHC class II epitope prediction |
| CN107326090B (zh) * | 2017-08-23 | 2020-05-26 | 武汉大学 | 用于非小细胞肺癌诊断的血小板LncRNA的定量检测方法 |
| ES2702617B2 (es) * | 2017-09-04 | 2019-11-18 | Univ Rovira I Virgili | Hidrolizados de garras de patas de pollo, sus péptidos y usos de los mismos |
| KR102034929B1 (ko) * | 2017-09-27 | 2019-10-22 | 한양대학교 산학협력단 | Nckap1 단백질 또는 상기 단백질을 암호화하는 유전자를 포함하는 신경계 퇴행성질환의 예방 또는 치료용 약학적 조성물 |
| CA3077084A1 (en) | 2017-10-05 | 2019-04-11 | Epivax, Inc. | Regulatory t cell epitopes |
| CN107641626B (zh) * | 2017-11-23 | 2018-06-01 | 黄志清 | 912位点发生突变的RanBP9突变基因及其应用 |
| WO2019117690A1 (ko) * | 2017-12-15 | 2019-06-20 | 경북대학교 산학협력단 | Pd-l1에 결합하는 펩타이드 및 이의 용도 |
| CN111492068B (zh) | 2017-12-19 | 2025-03-21 | 贝克顿迪金森公司 | 与寡核苷酸相关联的颗粒 |
| CN120818057A (zh) * | 2017-12-28 | 2025-10-21 | 磨石生物公司 | 靶向共同抗原的抗原结合蛋白 |
| KR20200122320A (ko) * | 2018-01-16 | 2020-10-27 | 씨엘에스 테라퓨틱스 리미티드 | 데옥시리보뉴클레아제 (dnase) 활성을 갖는 효소의 간 발현에 의한 질환의 치료 |
| CN108409851B (zh) * | 2018-01-29 | 2020-12-08 | 上海交通大学 | 肾细胞癌中高水平表达的蛋白及其应用 |
| KR20250099758A (ko) | 2018-01-31 | 2025-07-02 | 더 리서치 인스티튜트 앳 네이션와이드 칠드런스 하스피탈 | 2c형 지대근이영양증에 대한 유전자 치료 |
| US20210238690A1 (en) * | 2018-04-26 | 2021-08-05 | Intellexon Gmbh | Hla-j and medical/diagnostic uses thereof |
| CN112272710A (zh) | 2018-05-03 | 2021-01-26 | 贝克顿迪金森公司 | 高通量多组学样品分析 |
| CN118910215A (zh) | 2018-05-03 | 2024-11-08 | 贝克顿迪金森公司 | 在相对的转录物末端进行分子条形码化 |
| TW202016131A (zh) | 2018-05-16 | 2020-05-01 | 德商英麥提克生物技術股份有限公司 | 用於抗癌免疫治療的肽 |
| CN112543810A (zh) | 2018-06-29 | 2021-03-23 | 全国儿童医院研究所 | 治疗肢带型肌营养不良2a型的重组腺相关病毒产品和方法 |
| US11401339B2 (en) | 2018-08-23 | 2022-08-02 | Seagen Inc. | Anti-TIGIT antibodies |
| US11712410B2 (en) | 2018-09-05 | 2023-08-01 | K18, Inc. | Composition for improving hair health |
| US11639517B2 (en) | 2018-10-01 | 2023-05-02 | Becton, Dickinson And Company | Determining 5′ transcript sequences |
| JP7619939B2 (ja) | 2018-10-05 | 2025-01-22 | シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート | 原発性免疫不全症、シスチン症、及びウィルソン病に関する新生児スクリーニング |
| WO2020093018A1 (en) | 2018-11-01 | 2020-05-07 | University Of Florida Research Foundation, Incorporated | A codon optimized otoferlin aav dual vector gene therapy |
| US11932849B2 (en) | 2018-11-08 | 2024-03-19 | Becton, Dickinson And Company | Whole transcriptome analysis of single cells using random priming |
| TWI863941B (zh) | 2018-11-15 | 2024-12-01 | 美商寬騰矽公司 | 用於蛋白質定序之方法及組合物 |
| CN113195717A (zh) | 2018-12-13 | 2021-07-30 | 贝克顿迪金森公司 | 单细胞全转录组分析中的选择性延伸 |
| CN109456968B (zh) * | 2018-12-29 | 2022-10-04 | 上海奕谱生物科技有限公司 | 基于甲基化修饰的肿瘤标记物 |
| CN109651500B (zh) * | 2019-01-15 | 2021-08-13 | 南京蜂瑞生物科技有限公司 | 一种具有抑制白血病细胞增殖作用的多肽 |
| WO2020150356A1 (en) | 2019-01-16 | 2020-07-23 | Becton, Dickinson And Company | Polymerase chain reaction normalization through primer titration |
| EP4242322B1 (en) | 2019-01-23 | 2024-08-21 | Becton, Dickinson and Company | Oligonucleotides associated with antibodies |
| EP3921032A4 (en) | 2019-02-08 | 2022-11-30 | Decibel Therapeutics, Inc. | Compositions and methods for treating sensorineural hearing loss using otoferlin dual vector systems |
| EP3695883A1 (en) * | 2019-02-13 | 2020-08-19 | Alytas Therapeutics GmbH | Means for specifically eliminating perilipin-1 fragment presenting adipocytes |
| US12071617B2 (en) | 2019-02-14 | 2024-08-27 | Becton, Dickinson And Company | Hybrid targeted and whole transcriptome amplification |
| CN113785052B (zh) * | 2019-02-19 | 2024-06-28 | 维也纳兽医大学 | 新重组二胺氧化酶及其治疗以过量组胺为特征的疾病的用途 |
| CN113766935A (zh) | 2019-02-26 | 2021-12-07 | 全国儿童医院研究所 | β-肌聚糖的腺相关病毒载体递送和肌营养不良症的治疗 |
| JP7630176B2 (ja) | 2019-04-01 | 2025-02-17 | テナヤ セラピューティクス, インコーポレイテッド | 操作されたカプシドを有するアデノ随伴ウイルス |
| CN110045130B (zh) * | 2019-04-17 | 2022-03-29 | 中山大学附属第一医院 | 一种与IgA肾病相关的多肽的免疫分析检测试剂盒 |
| EP4252783A3 (en) * | 2019-07-10 | 2023-11-15 | Masonic Medical Research Laboratory | Vgll4 with ucp-1 cis-regulatory element and method of use thereof |
| US20220291220A1 (en) * | 2019-07-15 | 2022-09-15 | Oncocyte Corporation | Methods and compositions for detection and treatment of lung cancer |
| US11939622B2 (en) | 2019-07-22 | 2024-03-26 | Becton, Dickinson And Company | Single cell chromatin immunoprecipitation sequencing assay |
| EP4488287A3 (en) | 2019-08-21 | 2025-03-05 | Research Institute at Nationwide Children's Hospital | Adeno-associated virus vector delivery of alpha-sarcoglycan and the treatment of muscular dystrophy |
| WO2021050510A1 (en) * | 2019-09-09 | 2021-03-18 | The Wistar Institute Of Anatomy And Biology | Engineered peptide and peptide mimetic compositions and methods |
| CN110706749B (zh) * | 2019-09-10 | 2022-06-10 | 至本医疗科技(上海)有限公司 | 一种基于组织器官分化层次关系的癌症类型预测系统和方法 |
| US20220347279A1 (en) * | 2019-10-03 | 2022-11-03 | Board Of Regents, The University Of Texas System | Vcx/y peptides and use thereof |
| CN110669104B (zh) * | 2019-10-30 | 2021-11-05 | 上海交通大学 | 一组来源于人外周血单核细胞的标志物及其应用 |
| JP7522189B2 (ja) | 2019-11-08 | 2024-07-24 | ベクトン・ディキンソン・アンド・カンパニー | 免疫レパートリーシーケンシングのための完全長v(d)j情報を得るためのランダムプライミングの使用 |
| WO2021146207A1 (en) | 2020-01-13 | 2021-07-22 | Becton, Dickinson And Company | Methods and compositions for quantitation of proteins and rna |
| WO2021143932A1 (zh) * | 2020-01-19 | 2021-07-22 | 北京生命科学研究所 | 乙型肝炎病毒感染的特异性宿主因子及其应用 |
| ES2993319T3 (en) | 2020-01-29 | 2024-12-27 | Becton Dickinson Co | Barcoded wells for spatial mapping of single cells through sequencing |
| KR20220134571A (ko) * | 2020-01-31 | 2022-10-05 | 벤 바이오사이언시스 코포레이션 | 난소암 진단용 바이오마커 |
| EP3868884A1 (en) * | 2020-02-19 | 2021-08-25 | Aarhus Universitet | Method for subtyping bladder cancer using aptamers |
| CN115151810A (zh) | 2020-02-25 | 2022-10-04 | 贝克顿迪金森公司 | 实现使用单细胞样品作为单色补偿对照的双特异性探针 |
| KR20210121585A (ko) * | 2020-03-30 | 2021-10-08 | 한국세라믹기술원 | 반응성 및 안정성 그리고 항체회수가 향상된 z-도메인 및 칼시퀘스트린 융합단백질 및 이를 이용한 항체의 분리 및 정제 방법 |
| US11940448B2 (en) | 2020-03-31 | 2024-03-26 | Seattle Children's Hospital | Proteomic screening for lysosomal storage diseases |
| WO2021202817A1 (en) | 2020-04-01 | 2021-10-07 | University Of Florida Research Foundation, Incorporated | Dual aav-myo7a vectors with improved safety for the treatment of ush1b |
| IT202000006973A1 (it) * | 2020-04-02 | 2021-10-02 | Istituto Naz Tumori Irccs Fondazione G Pascale | Antigeni herv tumore-specifici e loro uso nella immunoterapia del cancro |
| WO2021226111A1 (en) * | 2020-05-04 | 2021-11-11 | University Of Utah Research Foundation | Immunothrombosis in covid-19 acute respiratory distress syndrome |
| CN115605614A (zh) | 2020-05-14 | 2023-01-13 | 贝克顿迪金森公司(Us) | 用于免疫组库谱分析的引物 |
| KR20230012052A (ko) * | 2020-05-20 | 2023-01-25 | 퀀텀-에스아이 인코포레이티드 | 단백질 시퀀싱을 위한 방법 및 조성물 |
| US20210371534A1 (en) * | 2020-06-01 | 2021-12-02 | Musc Foundation For Research Development | Recombinant Fusion Proteins Targeting P-selectin, and Methods of Use Thereof for Treating Diseases and Disorders |
| CN115803445A (zh) | 2020-06-02 | 2023-03-14 | 贝克顿迪金森公司 | 用于5撇基因表达测定的寡核苷酸和珠 |
| TW202216111A (zh) | 2020-07-03 | 2022-05-01 | 米尼奧大學 | 香氛釋放機制、方法及其用途 |
| US11932901B2 (en) | 2020-07-13 | 2024-03-19 | Becton, Dickinson And Company | Target enrichment using nucleic acid probes for scRNAseq |
| WO2022026909A1 (en) | 2020-07-31 | 2022-02-03 | Becton, Dickinson And Company | Single cell assay for transposase-accessible chromatin |
| WO2022031733A2 (en) * | 2020-08-03 | 2022-02-10 | Cornell University | Keratinolytic polypeptides and methods of use |
| BR112023003929A2 (pt) * | 2020-10-01 | 2023-04-11 | Genzyme Corp | Cassete de expressão de pah humano para tratamento de pku por terapia de reposição gênica direcionada ao fígado |
| US11781156B2 (en) * | 2020-10-09 | 2023-10-10 | Tenaya Therapeutics, Inc. | Plakophillin-2 gene therapy methods and compositions |
| US12012441B2 (en) | 2020-10-26 | 2024-06-18 | Neptune Biosciences Llc | Engineered human IL-21 cytokines and methods for using the same |
| WO2022109343A1 (en) | 2020-11-20 | 2022-05-27 | Becton, Dickinson And Company | Profiling of highly expressed and lowly expressed proteins |
| US12392771B2 (en) | 2020-12-15 | 2025-08-19 | Becton, Dickinson And Company | Single cell secretome analysis |
| CN112552394B (zh) * | 2020-12-30 | 2023-03-21 | 青海瑞肽生物科技有限公司 | 一种牦牛降压肽及其制备方法 |
| CN113061176B (zh) * | 2021-03-12 | 2022-08-16 | 华中农业大学 | 一种草鱼抗菌蛋白lect2及其制备方法和应用 |
| EP4324841A4 (en) * | 2021-04-15 | 2025-05-07 | Onecuregen Co., Ltd. | Cell-penetrating peptide, anticancer peptide and pharmaceutical composition for preventing or treating cancer therewith |
| CN117597364A (zh) * | 2021-05-12 | 2024-02-23 | 百进生物科技公司 | 抗ccr8抗体、其抗原结合片段、以及试剂和组合物及其制备和使用方法 |
| WO2023049541A1 (en) * | 2021-07-23 | 2023-03-30 | Cassava Sciences, Inc. | Blood-based diagnostic assays for alzheimer's disease |
| TWI800922B (zh) * | 2021-09-14 | 2023-05-01 | 東海大學 | 短胜肽、含有該短胜肽之水解物及其用於預防或/及治療神經損傷相關疾病之用途 |
| TWI838648B (zh) * | 2021-09-28 | 2024-04-11 | 臺北醫學大學 | 用於檢測大腸直腸癌的組合物的用途與方法 |
| TW202321440A (zh) * | 2021-10-07 | 2023-06-01 | 美商肝特斯公司 | 追蹤接受者中之供體細胞之方法 |
| EP4219726A1 (en) | 2021-10-15 | 2023-08-02 | Research Institute at Nationwide Children's Hospital | Self-complementary adeno-associated virus vector and its use in treatment of muscular dystrophy |
| CN114195884B (zh) * | 2021-10-27 | 2024-03-29 | 禾美生物科技(浙江)有限公司 | 一种重组人源胶原蛋白及其制备方法 |
| CN113845571B (zh) * | 2021-11-10 | 2023-08-15 | 华南理工大学 | 一种抑制肝癌细胞生长的活性多肽及其制备方法和应用 |
| GB2621640A (en) * | 2021-11-10 | 2024-02-21 | Univ South China Tech | Active polypeptide for inhibiting growth of liver cancer cells, and preparation method therefor and use thereof |
| WO2023092057A1 (en) * | 2021-11-18 | 2023-05-25 | Ionis Pharmaceuticals, Inc. | Compounds and methods for modulating progranulin expression |
| AU2022399828A1 (en) * | 2021-11-30 | 2024-05-23 | Venn Biosciences Corporation | Diagnosis of pancreatic cancer using targeted quantification of site-specific protein glycosylation |
| WO2023196898A1 (en) * | 2022-04-07 | 2023-10-12 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Beta globin mimetic peptides and their use |
| TWI845024B (zh) * | 2022-11-15 | 2024-06-11 | 長庚大學 | 用以診斷和預斷大腸直腸癌的方法 |
| WO2024115743A1 (en) * | 2022-12-02 | 2024-06-06 | Cézanne S.A.S. | Protein biomarkers for use in methods for the diagnosis or prognosis of chronic airflow limitation (cal) and chronic obstructive pulmonary disease (copd) |
| CN115894623B (zh) * | 2022-12-20 | 2025-05-13 | 中国科学院昆明动物研究所 | 一种具有双重调节dbh和ddc酶活性功能的多肽nr6及其应用 |
| CN116891523B (zh) * | 2023-05-24 | 2024-05-17 | 深圳晶蛋生物医药科技有限公司 | 一种trpm3截短体、包含其的细胞系及其用途 |
| WO2025003457A1 (en) * | 2023-06-29 | 2025-01-02 | University Of Fribourg | Targeted proteomics for monitoring autophagy |
| KR20250031017A (ko) * | 2023-08-23 | 2025-03-06 | 재단법인 아산사회복지재단 | Pibf1 또는 이를 코딩하는 유전자를 포함하는 벡터를 포함하는 태반 또는 태아 심혈관 이상과 관련된 임신 합병증의 예방 또는 치료용 약학 조성물 |
| CN119899273B (zh) * | 2025-01-15 | 2025-10-31 | 中国人民解放军空军军医大学 | 一种人pgk1第131位赖氨酸乳酸化修饰的抗体制备方法与应用 |
Family Cites Families (272)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US493495A (en) | 1893-03-14 | Lantern | ||
| US604823A (en) | 1898-05-31 | Op stratiidon | ||
| US197506A (en) | 1877-11-27 | Improvement in hernia-trusses | ||
| US4437975A (en) | 1977-07-20 | 1984-03-20 | Mobil Oil Corporation | Manufacture of lube base stock oil |
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4690715A (en) | 1982-06-18 | 1987-09-01 | American Telephone And Telegraph Company, At&T Bell Laboratories | Modification of the properties of metals |
| WO1984003506A1 (en) | 1983-03-08 | 1984-09-13 | Commw Serum Lab Commission | Antigenically active amino acid sequences |
| NZ207394A (en) | 1983-03-08 | 1987-03-06 | Commw Serum Lab Commission | Detecting or determining sequence of amino acids |
| CA1247080A (en) | 1983-03-08 | 1988-12-20 | Commonwealth Serum Laboratories Commission | Antigenically active amino acid sequences |
| US4483105A (en) | 1983-03-11 | 1984-11-20 | Maschinenfabrik Gehring, Gesellschaft Mit Beschrankter Haftung & Co. Kommanditgesellschaft | Device to hold workpieces for the honing of their axial center bore |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4644545A (en) | 1983-05-16 | 1987-02-17 | Data General Corporation | Digital encoding and decoding apparatus |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5242794A (en) | 1984-12-13 | 1993-09-07 | Applied Biosystems, Inc. | Detection of specific sequences in nucleic acids |
| US5333675C1 (en) | 1986-02-25 | 2001-05-01 | Perkin Elmer Corp | Apparatus and method for performing automated amplification of nucleic acid sequences and assays using heating and cooling steps |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| DE229046T1 (de) | 1985-03-30 | 1987-12-17 | Marc Genf/Geneve Ballivet | Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren. |
| US6492107B1 (en) | 1986-11-20 | 2002-12-10 | Stuart Kauffman | Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique |
| NZ215865A (en) | 1985-04-22 | 1988-10-28 | Commw Serum Lab Commission | Method of determining the active site of a receptor-binding analogue |
| US4886743A (en) * | 1985-04-24 | 1989-12-12 | California Institute Of Technology | Diagnostic reagents based on unique sequences within the variable region of the T cell receptor and uses thereof |
| US5045995A (en) | 1985-06-24 | 1991-09-03 | Vicom Systems, Inc. | Selective operation of processing elements in a single instruction multiple data stream (SIMD) computer system |
| US4965108A (en) | 1985-09-11 | 1990-10-23 | First Brands Corporation | Low temperature impact and puncture resistant thermoplastic films and bags therefrom |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
| IL86724A (en) | 1987-06-19 | 1995-01-24 | Siska Diagnostics Inc | Methods and kits for amplification and testing of nucleic acid sequences |
| US4833195A (en) | 1987-07-20 | 1989-05-23 | Bp Performance Polymers, Inc. | High flow drapable polymer compositions |
| JP2774121B2 (ja) | 1987-07-31 | 1998-07-09 | ザ ボード オブ トラスティーズ オブ ザ リーランド スタンフォード ジュニア ユニバーシティ | 標的ポリヌクレオチド配列の選択的増幅 |
| EP0308936B1 (en) | 1987-09-23 | 1994-07-06 | Bristol-Myers Squibb Company | Antibody heteroconjugates for the killing of HIV-infected cells |
| JP2650159B2 (ja) | 1988-02-24 | 1997-09-03 | アクゾ・ノベル・エヌ・ベー | 核酸増幅方法 |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| US4988617A (en) | 1988-03-25 | 1991-01-29 | California Institute Of Technology | Method of detecting a nucleotide change in nucleic acids |
| US5266684A (en) | 1988-05-02 | 1993-11-30 | The Reagents Of The University Of California | Peptide mixtures |
| US5571689A (en) | 1988-06-16 | 1996-11-05 | Washington University | Method of N-acylating peptide and proteins with diheteroatom substituted analogs of myristic acid |
| US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
| US5663143A (en) | 1988-09-02 | 1997-09-02 | Dyax Corp. | Engineered human-derived kunitz domains that inhibit human neutrophil elastase |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| HU216105B (hu) | 1988-12-16 | 1999-04-28 | Akzo Nobel N.V. | Amplifikációs eljárás önfenntartó szekvenciareplikációs rendszerrel |
| US5856092A (en) | 1989-02-13 | 1999-01-05 | Geneco Pty Ltd | Detection of a nucleic acid sequence or a change therein |
| US5081584A (en) | 1989-03-13 | 1992-01-14 | United States Of America | Computer-assisted design of anti-peptides based on the amino acid sequence of a target peptide |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5242974A (en) | 1991-11-22 | 1993-09-07 | Affymax Technologies N.V. | Polymer reversal on solid surfaces |
| US5925525A (en) | 1989-06-07 | 1999-07-20 | Affymetrix, Inc. | Method of identifying nucleotide differences |
| US5547839A (en) | 1989-06-07 | 1996-08-20 | Affymax Technologies N.V. | Sequencing of surface immobilized polymers utilizing microflourescence detection |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5424186A (en) | 1989-06-07 | 1995-06-13 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| US6346413B1 (en) | 1989-06-07 | 2002-02-12 | Affymetrix, Inc. | Polymer arrays |
| US5527681A (en) | 1989-06-07 | 1996-06-18 | Affymax Technologies N.V. | Immobilized molecular synthesis of systematically substituted compounds |
| US6309822B1 (en) | 1989-06-07 | 2001-10-30 | Affymetrix, Inc. | Method for comparing copy number of nucleic acid sequences |
| US5871928A (en) | 1989-06-07 | 1999-02-16 | Fodor; Stephen P. A. | Methods for nucleic acid analysis |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| AU641673B2 (en) | 1989-06-29 | 1993-09-30 | Medarex, Inc. | Bispecific reagents for aids therapy |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| ATE141956T1 (de) | 1989-07-11 | 1996-09-15 | Gen Probe Inc | Verfahren zur vervielfältigung von nukleinsäuresequenzen |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5252743A (en) | 1989-11-13 | 1993-10-12 | Affymax Technologies N.V. | Spatially-addressable immobilization of anti-ligands on surfaces |
| US5498538A (en) | 1990-02-15 | 1996-03-12 | The University Of North Carolina At Chapel Hill | Totally synthetic affinity reagents |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| US5494810A (en) | 1990-05-03 | 1996-02-27 | Cornell Research Foundation, Inc. | Thermostable ligase-mediated DNA amplifications system for the detection of genetic disease |
| US5723286A (en) | 1990-06-20 | 1998-03-03 | Affymax Technologies N.V. | Peptide library and screening systems |
| CA2090015A1 (en) | 1990-08-24 | 1992-02-25 | Brant J. Bassam | Dna amplification fingerprinting |
| WO1992003918A1 (en) | 1990-08-29 | 1992-03-19 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5698426A (en) | 1990-09-28 | 1997-12-16 | Ixsys, Incorporated | Surface expression libraries of heteromeric receptors |
| US5770434A (en) | 1990-09-28 | 1998-06-23 | Ixsys Incorporated | Soluble peptides having constrained, secondary conformation in solution and method of making same |
| CA2027434C (en) * | 1990-10-12 | 1999-01-05 | George Jackowski | Diagnostic kit for diagnosing and distinguishing chest pain in early onset thereof |
| WO1992007095A1 (en) | 1990-10-15 | 1992-04-30 | Stratagene | Arbitrarily primed polymerase chain reaction method for fingerprinting genomes |
| AU668347B2 (en) | 1990-11-21 | 1996-05-02 | Torrey Pines Institute For Molecular Studies | Synthesis of equimolar multiple oligomer mixtures, especially of oligopeptide mixtures |
| DK0564531T3 (da) | 1990-12-03 | 1998-09-28 | Genentech Inc | Berigelsesfremgangsmåde for variantproteiner med ændrede bindingsegenskaber |
| US6582908B2 (en) | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| CA2102511A1 (en) | 1991-05-14 | 1992-11-15 | Paul J. Higgins | Heteroconjugate antibodies for treatment of hiv infection |
| US5539082A (en) | 1993-04-26 | 1996-07-23 | Nielsen; Peter E. | Peptide nucleic acids |
| CA2103059C (en) | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| US5270170A (en) | 1991-10-16 | 1993-12-14 | Affymax Technologies N.V. | Peptide library and screening method |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| US5270184A (en) | 1991-11-19 | 1993-12-14 | Becton, Dickinson And Company | Nucleic acid target generation |
| US5412087A (en) | 1992-04-24 | 1995-05-02 | Affymax Technologies N.V. | Spatially-addressable immobilization of oligonucleotides and other biological polymers on surfaces |
| ATE293011T1 (de) | 1991-11-22 | 2005-04-15 | Affymetrix Inc A Delaware Corp | Kombinatorische strategien für die polymersynthese |
| US5550215A (en) | 1991-11-22 | 1996-08-27 | Holmes; Christopher P. | Polymer reversal on solid surfaces |
| US5384261A (en) | 1991-11-22 | 1995-01-24 | Affymax Technologies N.V. | Very large scale immobilized polymer synthesis using mechanically directed flow paths |
| US5324633A (en) | 1991-11-22 | 1994-06-28 | Affymax Technologies N.V. | Method and apparatus for measuring binding affinity |
| IT1252624B (it) | 1991-12-05 | 1995-06-19 | Cons Ric Microelettronica | Dispositivo semiconduttore incapsulato in resina e elettricamente isolato di migliorate caratteristiche di isolamento,e relativo processo di fabbricazione |
| US5346994A (en) | 1992-01-28 | 1994-09-13 | Piotr Chomczynski | Shelf-stable product and process for isolating RNA, DNA and proteins |
| DE69333807T2 (de) | 1992-02-06 | 2006-02-02 | Chiron Corp., Emeryville | Marker für krebs und biosynthetisches bindeprotein dafür |
| CA2064683A1 (en) | 1992-03-26 | 1993-09-27 | Krishna Mohan Rao Kallury | Formation of thermostable enzymes with extra-ordinary heat tolerance by immobilization on phospholipid matrices |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| GB9208733D0 (en) | 1992-04-22 | 1992-06-10 | Medical Res Council | Dna sequencing method |
| US5541061A (en) | 1992-04-29 | 1996-07-30 | Affymax Technologies N.V. | Methods for screening factorial chemical libraries |
| CA2140280A1 (en) | 1992-08-17 | 1994-03-03 | Avi J. Ashkenazi | Bispecific immunoadhesins |
| DE69329503T2 (de) | 1992-11-13 | 2001-05-03 | Idec Pharma Corp | Therapeutische Verwendung von chimerischen und markierten Antikörpern, die gegen ein Differenzierung-Antigen gerichtet sind, dessen Expression auf menschliche B Lymphozyt beschränkt ist, für die Behandlung von B-Zell-Lymphoma |
| FR2703359B1 (fr) | 1993-03-31 | 1995-06-23 | Cis Bio Int | Copolymère nucléotide(s)/polymère conducteur électronique ; son procédé de préparation et son utilisation . |
| US5491074A (en) | 1993-04-01 | 1996-02-13 | Affymax Technologies Nv | Association peptides |
| US5312790A (en) | 1993-06-09 | 1994-05-17 | The United States Of America As Represented By The Secretary Of The Army | Ceramic ferroelectric material |
| US5858659A (en) | 1995-11-29 | 1999-01-12 | Affymetrix, Inc. | Polymorphism detection |
| DE69431719T2 (de) | 1993-06-25 | 2003-09-18 | Affymetrix, Inc. (N.D.Ges.D.Staates Delaware) | Hybridisierung und sequenzierung von nukleinsäuren |
| US5837832A (en) | 1993-06-25 | 1998-11-17 | Affymetrix, Inc. | Arrays of nucleic acid probes on biological chips |
| ATE208658T1 (de) | 1993-07-28 | 2001-11-15 | Pe Corp Ny | Vorrichtung und verfahren zur nukleinsäurevervielfältigung |
| US6045996A (en) | 1993-10-26 | 2000-04-04 | Affymetrix, Inc. | Hybridization assays on oligonucleotide arrays |
| US5429708A (en) | 1993-12-22 | 1995-07-04 | The Board Of Trustees Of The Leland Stanford Junior University | Molecular layers covalently bonded to silicon surfaces |
| US5631734A (en) | 1994-02-10 | 1997-05-20 | Affymetrix, Inc. | Method and apparatus for detection of fluorescently labeled materials |
| US6090555A (en) | 1997-12-11 | 2000-07-18 | Affymetrix, Inc. | Scanned image alignment systems and methods |
| US5578832A (en) | 1994-09-02 | 1996-11-26 | Affymetrix, Inc. | Method and apparatus for imaging a sample on a device |
| JP3552264B2 (ja) | 1994-03-04 | 2004-08-11 | ヤマハ株式会社 | 自動演奏装置 |
| US5648211A (en) | 1994-04-18 | 1997-07-15 | Becton, Dickinson And Company | Strand displacement amplification using thermophilic enzymes |
| DE69503126T2 (de) | 1994-05-05 | 1998-11-12 | Beckman Instruments Inc | Repetitive oligonukleotide matrix |
| US5571639A (en) | 1994-05-24 | 1996-11-05 | Affymax Technologies N.V. | Computer-aided engineering system for design of sequence arrays and lithographic masks |
| WO1995034683A1 (en) | 1994-06-10 | 1995-12-21 | Symbiotech, Inc. | Method of detecting compounds utilizing genetically modified lambdoid bacteriophage |
| US5403464A (en) | 1994-06-15 | 1995-04-04 | Modern Controls, Inc. | High permeability rate oxygen sensor |
| US5807522A (en) | 1994-06-17 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for fabricating microarrays of biological samples |
| US5627024A (en) | 1994-08-05 | 1997-05-06 | The Scripps Research Institute | Lambdoid bacteriophage vectors for expression and display of foreign proteins |
| US5620850A (en) | 1994-09-26 | 1997-04-15 | President And Fellows Of Harvard College | Molecular recognition at surfaces derivatized with self-assembled monolayers |
| US6013445A (en) | 1996-06-06 | 2000-01-11 | Lynx Therapeutics, Inc. | Massively parallel signature sequencing by ligation of encoded adaptors |
| US5695934A (en) | 1994-10-13 | 1997-12-09 | Lynx Therapeutics, Inc. | Massively parallel sequencing of sorted polynucleotides |
| US5846719A (en) | 1994-10-13 | 1998-12-08 | Lynx Therapeutics, Inc. | Oligonucleotide tags for sorting and identification |
| US5545539A (en) | 1994-10-18 | 1996-08-13 | Genzyme Corporation | Method for nucleotide sequence amplification |
| US5795716A (en) | 1994-10-21 | 1998-08-18 | Chee; Mark S. | Computer-aided visualization and analysis system for sequence evaluation |
| US6214388B1 (en) | 1994-11-09 | 2001-04-10 | The Regents Of The University Of California | Immunoliposomes that optimize internalization into target cells |
| US5688642A (en) | 1994-12-01 | 1997-11-18 | The United States Of America As Represented By The Secretary Of The Navy | Selective attachment of nucleic acid molecules to patterned self-assembled surfaces |
| CA2207869A1 (en) | 1994-12-02 | 1996-06-06 | Chiron Corporation | Method of promoting an immune response with a bispecific antibody |
| NO179986C (no) | 1994-12-08 | 1997-01-22 | Norske Stats Oljeselskap | Fremgangsmåte og system for fremstilling av flytendegjort naturgass til havs |
| US6270962B1 (en) | 1995-01-30 | 2001-08-07 | The Regents Of The University Of California | Methods for the elimination of DNA sequencing artifacts |
| US5599695A (en) | 1995-02-27 | 1997-02-04 | Affymetrix, Inc. | Printing molecular library arrays using deprotection agents solely in the vapor phase |
| US5959098A (en) | 1996-04-17 | 1999-09-28 | Affymetrix, Inc. | Substrate preparation process |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
| US5739277A (en) | 1995-04-14 | 1998-04-14 | Genentech Inc. | Altered polypeptides with increased half-life |
| US5624711A (en) | 1995-04-27 | 1997-04-29 | Affymax Technologies, N.V. | Derivatization of solid supports and methods for oligomer synthesis |
| WO1996038726A1 (en) | 1995-05-30 | 1996-12-05 | Ecole Polytechnique Federale De Lausanne (Epfl) | Covalently immobilized phospholipid bilayers on solid surfaces |
| US5545531A (en) | 1995-06-07 | 1996-08-13 | Affymax Technologies N.V. | Methods for making a device for concurrently processing multiple biological chip assays |
| US5837234A (en) | 1995-06-07 | 1998-11-17 | Cytotherapeutics, Inc. | Bioartificial organ containing cells encapsulated in a permselective polyether suflfone membrane |
| US5968740A (en) | 1995-07-24 | 1999-10-19 | Affymetrix, Inc. | Method of Identifying a Base in a Nucleic Acid |
| US5671894A (en) | 1995-08-11 | 1997-09-30 | Alliedsignal Inc. | Retractor with load limiting spool with decoupled pretensioner |
| DK0854933T3 (da) | 1995-09-07 | 2003-07-21 | Novozymes As | Fagfremvisning for detergentenzym aktivitet |
| US5733729A (en) | 1995-09-14 | 1998-03-31 | Affymetrix, Inc. | Computer-aided probability base calling for arrays of nucleic acid probes on chips |
| EP0852004B1 (en) | 1995-10-11 | 2011-01-19 | Luminex Corporation | Multiplexed analysis of clinical specimens |
| DE19544393A1 (de) | 1995-11-15 | 1997-05-22 | Hoechst Schering Agrevo Gmbh | Synergistische herbizide Mischungen |
| US6300063B1 (en) | 1995-11-29 | 2001-10-09 | Affymetrix, Inc. | Polymorphism detection |
| US6063026A (en) * | 1995-12-07 | 2000-05-16 | Carbon Based Corporation | Medical diagnostic analysis system |
| US6147205A (en) | 1995-12-15 | 2000-11-14 | Affymetrix, Inc. | Photocleavable protecting groups and methods for their use |
| EP0914335A2 (en) * | 1996-03-15 | 1999-05-12 | Corixa Corporation | Compounds and methods for immunotherapy and immunodiagnosis of prostate cancer |
| AU713744B2 (en) | 1996-03-20 | 1999-12-09 | Dyax Corp. | Engineering affinity ligands for macromolecules |
| US6114122A (en) | 1996-03-26 | 2000-09-05 | Affymetrix, Inc. | Fluidics station with a mounting system and method of using |
| EP0902885A4 (en) | 1996-05-16 | 2006-09-27 | Affymetrix Inc | SYSTEMS AND METHODS FOR DETECTION OF BRANDED PRODUCTS |
| KR20000016414A (ko) | 1996-06-06 | 2000-03-25 | 와이즈먼 앤드루 | Apl 면역반응성 펩티드, 그것의 콘주게이트 및 apl항체-매개병변의 치료방법 |
| JP2880453B2 (ja) | 1996-06-07 | 1999-04-12 | 三桜工業株式会社 | 配管用継手装置のリテーナ |
| AU735015B2 (en) | 1996-06-10 | 2001-06-28 | Scripps Research Institute, The | Use of substrate subtraction libraries to distinguish enzyme specificities |
| US5766905A (en) | 1996-06-14 | 1998-06-16 | Associated Universities Inc. | Cytoplasmic bacteriophage display system |
| US5922845A (en) | 1996-07-11 | 1999-07-13 | Medarex, Inc. | Therapeutic multispecific compounds comprised of anti-Fcα receptor antibodies |
| DE69736667T2 (de) | 1996-07-16 | 2007-09-06 | Gen-Probe Inc., San Diego | Verfahren zum nachweis und amplifikation von nukleinsäuresequenzen unter verbrauch von modifizierten oligonukleotiden mit erhöhter zielschmelztemperatur (tm) |
| WO1998014277A1 (en) | 1996-10-04 | 1998-04-09 | Whatman, Inc. | Device and method for simultaneous multiple chemical syntheses |
| AU4474497A (en) | 1996-10-08 | 1998-05-05 | U-Bisys B.V. | Methods and means for selecting peptides and proteins having specific affinity for a target |
| CA2268740C (en) | 1996-11-06 | 2010-07-20 | Sequenom, Inc. | High density immobilization of nucleic acids |
| WO1998020036A1 (en) | 1996-11-06 | 1998-05-14 | Genentech, Inc. | Constrained helical peptides and methods of making same |
| IL119587A (en) | 1996-11-07 | 2000-12-06 | Univ Ramot | Method of preparing and for obtaining bimolecular interactions |
| IL119586A (en) | 1996-11-07 | 2001-09-13 | Univ Ramot | Discontinuous library of a single biological unit and a method for its preparation |
| US6025681A (en) | 1997-02-05 | 2000-02-15 | Duly Research Inc. | Dielectric supported radio-frequency cavities |
| JP3756313B2 (ja) | 1997-03-07 | 2006-03-15 | 武 今西 | 新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体 |
| US6969488B2 (en) | 1998-05-22 | 2005-11-29 | Solexa, Inc. | System and apparatus for sequential processing of analytes |
| WO1998056954A1 (en) | 1997-06-13 | 1998-12-17 | Affymetrix, Inc. | Method to detect gene polymorphisms and monitor allelic expression employing a probe array |
| US6333179B1 (en) | 1997-06-20 | 2001-12-25 | Affymetrix, Inc. | Methods and compositions for multiplex amplification of nucleic acids |
| US6172211B1 (en) * | 1997-07-11 | 2001-01-09 | Boehringer Ingelheim International Gmbh | Nucleic acid encoding tag7 polypeptide |
| EP1009861A4 (en) | 1997-07-25 | 2002-10-16 | Affymetrix Inc | GENE EXPRESSION AND EVALUATION SYSTEM |
| US6420108B2 (en) | 1998-02-09 | 2002-07-16 | Affymetrix, Inc. | Computer-aided display for comparative gene expression |
| US5878832A (en) | 1997-08-13 | 1999-03-09 | General Motors Corporation | Steering apparatus for motor vehicle |
| US6223127B1 (en) | 1997-08-15 | 2001-04-24 | Affymetrix, Inc. | Polymorphism detection utilizing clustering analysis |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US6124120A (en) | 1997-10-08 | 2000-09-26 | Yale University | Multiple displacement amplification |
| US6033860A (en) | 1997-10-31 | 2000-03-07 | Affymetrix, Inc. | Expression profiles in adult and fetal organs |
| US6013449A (en) | 1997-11-26 | 2000-01-11 | The United States Of America As Represented By The Department Of Health And Human Services | Probe-based analysis of heterozygous mutations using two-color labelling |
| US6201639B1 (en) | 1998-03-20 | 2001-03-13 | James W. Overbeck | Wide field of view and high speed scanning microscopy |
| US6428752B1 (en) | 1998-05-14 | 2002-08-06 | Affymetrix, Inc. | Cleaning deposit devices that form microarrays and the like |
| US6269846B1 (en) | 1998-01-13 | 2001-08-07 | Genetic Microsystems, Inc. | Depositing fluid specimens on substrates, resulting ordered arrays, techniques for deposition of arrays |
| US6185030B1 (en) | 1998-03-20 | 2001-02-06 | James W. Overbeck | Wide field of view and high speed scanning microscopy |
| US6020135A (en) | 1998-03-27 | 2000-02-01 | Affymetrix, Inc. | P53-regulated genes |
| US5936324A (en) | 1998-03-30 | 1999-08-10 | Genetic Microsystems Inc. | Moving magnet scanner |
| US6525185B1 (en) | 1998-05-07 | 2003-02-25 | Affymetrix, Inc. | Polymorphisms associated with hypertension |
| US6335155B1 (en) | 1998-06-26 | 2002-01-01 | Sunesis Pharmaceuticals, Inc. | Methods for rapidly identifying small organic molecule ligands for binding to biological target molecules |
| US6787308B2 (en) | 1998-07-30 | 2004-09-07 | Solexa Ltd. | Arrayed biomolecules and their use in sequencing |
| US6171239B1 (en) | 1998-08-17 | 2001-01-09 | Emory University | Systems, methods, and devices for controlling external devices by signals derived directly from the nervous system |
| US6185561B1 (en) | 1998-09-17 | 2001-02-06 | Affymetrix, Inc. | Method and apparatus for providing and expression data mining database |
| AR021833A1 (es) | 1998-09-30 | 2002-08-07 | Applied Research Systems | Metodos de amplificacion y secuenciacion de acido nucleico |
| US6262216B1 (en) | 1998-10-13 | 2001-07-17 | Affymetrix, Inc. | Functionalized silicon compounds and methods for their synthesis and use |
| WO2000024939A1 (en) | 1998-10-27 | 2000-05-04 | Affymetrix, Inc. | Complexity management and analysis of genomic dna |
| US6252743B1 (en) | 1998-11-02 | 2001-06-26 | Read-Rite Corporation | Read/write positioning arm with interspaced amplifier chips |
| WO2000028082A1 (fr) | 1998-11-09 | 2000-05-18 | Eiken Kagaku Kabushiki Kaisha | Procede de synthese d'acide nucleique |
| JP2002533726A (ja) | 1998-12-28 | 2002-10-08 | サネシス ファーマシューティカルス インコーポレイテッド | 結合のための小有機分子リガンドの同定 |
| US6470305B1 (en) | 1998-12-31 | 2002-10-22 | Ajay N. Jain | Chemical analysis by morphological similarity |
| US20060134637A1 (en) | 1999-01-06 | 2006-06-22 | Chondrogene Limited | Method for the detection of cancer related gene transcripts in blood |
| US6492505B1 (en) * | 1999-02-01 | 2002-12-10 | Incyte Genomics, Inc. | Composition for detection of genes encoding membrane-associated proteins |
| US6177248B1 (en) | 1999-02-24 | 2001-01-23 | Affymetrix, Inc. | Downstream genes of tumor suppressor WT1 |
| JP2002539849A (ja) | 1999-03-26 | 2002-11-26 | ホワイトヘッド インスチチュート フォアー バイオメディカル リサーチ | ユニバーサルアレイ |
| US6268141B1 (en) | 1999-05-12 | 2001-07-31 | Beckman Coulter, Inc. | Immobilization of unmodified biopolymers to acyl fluoride activated substrates |
| US6026601A (en) | 1999-05-25 | 2000-02-22 | Kiel; Walter J. | Ironing board adapted to vertical surface |
| US6300070B1 (en) | 1999-06-04 | 2001-10-09 | Mosaic Technologies, Inc. | Solid phase methods for amplifying multiple nucleic acids |
| US6218803B1 (en) | 1999-06-04 | 2001-04-17 | Genetic Microsystems, Inc. | Position sensing with variable capacitance transducers |
| WO2001023610A2 (en) | 1999-09-29 | 2001-04-05 | Solexa Ltd. | Polynucleotide sequencing |
| US6958225B2 (en) | 1999-10-27 | 2005-10-25 | Affymetrix, Inc. | Complexity management of genomic DNA |
| DE19957827C2 (de) | 1999-11-25 | 2003-06-12 | Epigenomics Ag | Verwendung eines Oligomer-Arrays mit PNA- und/oder DNA-Oligomeren auf einer Oberfläche |
| IL150018A0 (en) * | 1999-12-06 | 2002-12-01 | Agensys Inc | Novel serpentine transmembrane antigens expressed in human cancers and uses thereof |
| US6582938B1 (en) | 2001-05-11 | 2003-06-24 | Affymetrix, Inc. | Amplification of nucleic acids |
| US20030097222A1 (en) | 2000-01-25 | 2003-05-22 | Craford David M. | Method, system, and computer software for providing a genomic web portal |
| JP3490368B2 (ja) | 2000-02-07 | 2004-01-26 | インターナショナル・ビジネス・マシーンズ・コーポレーション | 信号出力装置、ドライバ回路、信号伝送システム、および信号伝送方法 |
| US6267152B1 (en) | 2000-02-18 | 2001-07-31 | Wisconsin Label Corporation | Hang tag and method of applying hang tag to an elongated object |
| US6696620B2 (en) | 2000-05-02 | 2004-02-24 | Epicyte Pharmaceutical, Inc. | Immunoglobulin binding protein arrays in eukaryotic cells |
| US6593425B2 (en) | 2000-05-31 | 2003-07-15 | General Electric Company | Data storage media containing transparent polycarbonate blends |
| US20060166227A1 (en) | 2000-06-20 | 2006-07-27 | Stephen Kingsmore | Protein expression profiling |
| US6531283B1 (en) | 2000-06-20 | 2003-03-11 | Molecular Staging, Inc. | Protein expression profiling |
| US6386749B1 (en) | 2000-06-26 | 2002-05-14 | Affymetrix, Inc. | Systems and methods for heating and mixing fluids |
| US6323009B1 (en) | 2000-06-28 | 2001-11-27 | Molecular Staging, Inc. | Multiply-primed amplification of nucleic acid sequences |
| US7567870B1 (en) * | 2000-07-31 | 2009-07-28 | Institute For Systems Biology | Multiparameter analysis for predictive medicine |
| JP2002071687A (ja) | 2000-08-31 | 2002-03-12 | Canon Inc | 変異遺伝子のスクリーニング方法 |
| US6897023B2 (en) | 2000-09-27 | 2005-05-24 | The Molecular Sciences Institute, Inc. | Method for determining relative abundance of nucleic acid sequences |
| EP1390523B1 (en) * | 2000-11-20 | 2007-05-09 | Eastern Virginia Medical School | Methods and devices for the quantitative detection of prostate specific membrane antigen and other prostatic markers |
| US6391592B1 (en) | 2000-12-14 | 2002-05-21 | Affymetrix, Inc. | Blocker-aided target amplification of nucleic acids |
| US6448387B1 (en) | 2000-12-18 | 2002-09-10 | Monsanto Technology, Llc | Polymeric arrays adapted for high expressing polynucleotides |
| US6405783B1 (en) | 2000-12-23 | 2002-06-18 | Advanced Innovations, Llc. | Horizontal window blind apparatus |
| US20020183936A1 (en) | 2001-01-24 | 2002-12-05 | Affymetrix, Inc. | Method, system, and computer software for providing a genomic web portal |
| US20030120432A1 (en) | 2001-01-29 | 2003-06-26 | Affymetrix, Inc. | Method, system and computer software for online ordering of custom probe arrays |
| US6689568B2 (en) | 2001-02-01 | 2004-02-10 | Agilent Technologies, Inc. | Capture arrays using polypeptide capture agents |
| US7713705B2 (en) * | 2002-12-24 | 2010-05-11 | Biosite, Inc. | Markers for differential diagnosis and methods of use thereof |
| WO2002084252A2 (en) | 2001-04-17 | 2002-10-24 | Xenoport, Inc. | Epitope-captured antibody display |
| US7473767B2 (en) | 2001-07-03 | 2009-01-06 | The Institute For Systems Biology | Methods for detection and quantification of analytes in complex mixtures |
| US20030100995A1 (en) | 2001-07-16 | 2003-05-29 | Affymetrix, Inc. | Method, system and computer software for variant information via a web portal |
| US6632611B2 (en) | 2001-07-20 | 2003-10-14 | Affymetrix, Inc. | Method of target enrichment and amplification |
| US6872529B2 (en) | 2001-07-25 | 2005-03-29 | Affymetrix, Inc. | Complexity management of genomic DNA |
| US7343247B2 (en) | 2001-07-30 | 2008-03-11 | The Institute For Systems Biology | Methods of classifying drug responsiveness using multiparameter analysis |
| US7229774B2 (en) * | 2001-08-02 | 2007-06-12 | Regents Of The University Of Michigan | Expression profile of prostate cancer |
| US20030044320A1 (en) | 2001-08-31 | 2003-03-06 | Shun Luo | High throughput screening micro array platform |
| US7057026B2 (en) | 2001-12-04 | 2006-06-06 | Solexa Limited | Labelled nucleotides |
| AU2002357147A1 (en) * | 2001-12-14 | 2003-06-30 | Incyte Genomics, Inc. | Transporters and ion channels |
| US20040002818A1 (en) | 2001-12-21 | 2004-01-01 | Affymetrix, Inc. | Method, system and computer software for providing microarray probe data |
| US7011945B2 (en) | 2001-12-21 | 2006-03-14 | Eastman Kodak Company | Random array of micro-spheres for the analysis of nucleic acids |
| US20030219801A1 (en) | 2002-03-06 | 2003-11-27 | Affymetrix, Inc. | Aptamer base technique for ligand identification |
| DE60332406D1 (de) | 2002-03-15 | 2010-06-17 | Affymetrix Inc | System und Verfahren zur Abtastung von biologischen Materialien |
| US20040049354A1 (en) | 2002-04-26 | 2004-03-11 | Affymetrix, Inc. | Method, system and computer software providing a genomic web portal for functional analysis of alternative splice variants |
| US20040126840A1 (en) | 2002-12-23 | 2004-07-01 | Affymetrix, Inc. | Method, system and computer software for providing genomic ontological data |
| EP1362929A3 (en) | 2002-05-17 | 2004-05-19 | Affymetrix, Inc. | Methods for genotyping |
| ES2346646T5 (es) | 2002-05-30 | 2018-02-15 | The Scripps Research Institute | Ligación catalizada con cobre de azidas y acetilenos |
| EP1514107B1 (en) | 2002-06-03 | 2013-05-15 | The Institute for Systems Biology | Methods for quantitative proteome analysis of glycoproteins |
| US20040072217A1 (en) | 2002-06-17 | 2004-04-15 | Affymetrix, Inc. | Methods of analysis of linkage disequilibrium |
| US7011949B2 (en) | 2002-09-30 | 2006-03-14 | Agilent Technologies, Inc. | Methods and compositions for producing labeled probe nucleic acids for use in array based comparative genomic hybridization applications |
| US7459273B2 (en) | 2002-10-04 | 2008-12-02 | Affymetrix, Inc. | Methods for genotyping selected polymorphism |
| AU2003291481A1 (en) | 2002-11-11 | 2004-06-03 | Affymetrix, Inc. | Methods for identifying dna copy number changes |
| CA2511501A1 (en) * | 2002-12-24 | 2004-07-15 | Biosite Incorporated | Markers for differential diagnosis and methods of use thereof |
| US20040146883A1 (en) | 2003-01-28 | 2004-07-29 | Affymetrix, Inc. | Methods for prenatal diagnosis |
| US7028629B2 (en) | 2003-02-03 | 2006-04-18 | Richard Walcome | Self-sealing port light assembly |
| AU2004264948A1 (en) * | 2003-08-15 | 2005-02-24 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Multifactorial assay for cancer detection |
| US20060094064A1 (en) * | 2003-11-19 | 2006-05-04 | Sandip Ray | Methods and compositions for diagnosis, stratification, and monitoring of alzheimer's disease and other neurological disorders in body fluids |
| AU2005241003B2 (en) | 2004-04-14 | 2011-05-19 | President And Fellows Of Harvard College | Nucleic-acid programmable protein arrays |
| EP1607898A3 (en) | 2004-05-18 | 2006-03-29 | Neal E. Solomon | A bioinformatics system for functional proteomics modelling |
| DK1766412T3 (da) | 2004-05-21 | 2009-05-25 | Inst Systems Biology | Sammensætninger og fremgangsmåder til kvantificering af serumglycoproteiner |
| CA2572451C (en) * | 2004-06-02 | 2016-05-10 | Sidney Kimmel Cancer Center | Annexin a1 based vascular targets for detecting, imaging and treating neoplasia or neovasculature |
| US7883858B2 (en) * | 2005-01-27 | 2011-02-08 | Institute For Systems Biology | Methods for identifying and monitoring drug side effects |
| US9002652B1 (en) * | 2005-01-27 | 2015-04-07 | Institute For Systems Biology | Methods for identifying and using organ-specific proteins in blood |
| US20070099251A1 (en) * | 2005-10-17 | 2007-05-03 | Institute For Systems Biology | Tissue-and serum-derived glycoproteins and methods of their use |
| AU2007284651B2 (en) * | 2006-08-09 | 2014-03-20 | Institute For Systems Biology | Organ-specific proteins and methods of their use |
| CN102803955B (zh) * | 2009-05-21 | 2015-10-21 | 系统生物学研究所 | 肝损伤的新标志物 |
-
2007
- 2007-08-09 AU AU2007284651A patent/AU2007284651B2/en not_active Ceased
- 2007-08-09 WO PCT/US2007/017868 patent/WO2008021290A2/en not_active Ceased
- 2007-08-09 JP JP2009523868A patent/JP5244103B2/ja not_active Expired - Fee Related
- 2007-08-09 CA CA002660286A patent/CA2660286A1/en not_active Abandoned
- 2007-08-09 EP EP07836742A patent/EP2057465A4/en not_active Ceased
- 2007-08-09 EP EP12174646A patent/EP2520935A3/en not_active Ceased
- 2007-08-09 US US12/376,951 patent/US8586006B2/en active Active
-
2013
- 2013-11-05 US US14/072,651 patent/US20140106981A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| EP2057465A2 (en) | 2009-05-13 |
| CA2660286A1 (en) | 2008-02-21 |
| US8586006B2 (en) | 2013-11-19 |
| WO2008021290A9 (en) | 2009-04-16 |
| AU2007284651B2 (en) | 2014-03-20 |
| US20120087862A1 (en) | 2012-04-12 |
| EP2057465A4 (en) | 2010-04-21 |
| WO2008021290A2 (en) | 2008-02-21 |
| WO2008021290A8 (en) | 2008-04-17 |
| WO2008021290A3 (en) | 2008-11-13 |
| JP2010500568A (ja) | 2010-01-07 |
| AU2007284651A1 (en) | 2008-02-21 |
| EP2520935A3 (en) | 2013-02-13 |
| EP2520935A2 (en) | 2012-11-07 |
| US20140106981A1 (en) | 2014-04-17 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5244103B2 (ja) | 器官特異的蛋白質およびその使用方法 | |
| JP2010500568A5 (cg-RX-API-DMAC7.html) | ||
| CN105755112B (zh) | 结肠直肠癌的诊断 | |
| US20070099251A1 (en) | Tissue-and serum-derived glycoproteins and methods of their use | |
| EP3732489B1 (en) | Novel biomarkers and methods for diagnosing and evaluating traumatic brain injury | |
| CN104969071B (zh) | 用于评估结肠肿瘤的存在或风险的方法 | |
| US8969009B2 (en) | Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual | |
| JP2018153184A (ja) | 広汎性発達障害の診断および治療のための組成物および方法 | |
| CN107533058A (zh) | 使用蛋白、肽和寡核苷酸抗原诊断系统性红斑狼疮 | |
| JP2017520775A (ja) | 結腸直腸腫瘍を検出するためのタンパク質バイオマーカープロファイル | |
| JP6104796B2 (ja) | 方法、アレイ、およびこれらの使用 | |
| JP2008545139A (ja) | 急性冠症候群の診断方法及び診断キット | |
| CN101313220A (zh) | 肝细胞癌的分子标志物及其应用 | |
| US9410965B2 (en) | Identification of discriminant proteins through antibody profiling, methods and apparatus for identifying an individual | |
| JP2019526810A (ja) | バイオマーカーサインおよびそれらの使用 | |
| US9921225B2 (en) | Phenyl glyoxal probes | |
| US20210333275A1 (en) | Pan-isotype immunoglobulin fingerprinting | |
| Cox et al. | Fingerprinting disease-derived protein aggregates reveals unique signature of Motor Neuron Disease | |
| CN116413430B (zh) | 一种用于肝癌早期预测的自身抗体/抗原组合及检测试剂盒 | |
| EP3157543B1 (en) | Compositions and methods for the diagnosis of systemic autoimmune disease | |
| US20140274758A1 (en) | Antibody profiling, methods and apparatus for identifying an individual or source of a biological material | |
| US20030092197A1 (en) | Proteins, genes and their use for diagnosis and treatment of cardiac response | |
| KR20200077779A (ko) | 퇴행성 뇌질환 발병 위험성 예측용 조성물 및 이를 이용한 퇴행성 뇌질환의 발병 위험성 예측 방법 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20100806 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20100806 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110803 |
|
| A524 | Written submission of copy of amendment under article 19 pct |
Free format text: JAPANESE INTERMEDIATE CODE: A524 Effective date: 20110909 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20120118 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20120820 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20120822 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20121119 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20121127 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20121219 |
|
| A602 | Written permission of extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A602 Effective date: 20121227 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20130207 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20130306 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20130405 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20160412 Year of fee payment: 3 |
|
| R150 | Certificate of patent or registration of utility model |
Free format text: JAPANESE INTERMEDIATE CODE: R150 Ref document number: 5244103 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| S111 | Request for change of ownership or part of ownership |
Free format text: JAPANESE INTERMEDIATE CODE: R313117 |
|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |