ATE496288T1 - Gleichzeitige mehrfachanalyse klinischer proben - Google Patents

Gleichzeitige mehrfachanalyse klinischer proben

Info

Publication number
ATE496288T1
ATE496288T1 AT96936310T AT96936310T ATE496288T1 AT E496288 T1 ATE496288 T1 AT E496288T1 AT 96936310 T AT96936310 T AT 96936310T AT 96936310 T AT96936310 T AT 96936310T AT E496288 T1 ATE496288 T1 AT E496288T1
Authority
AT
Austria
Prior art keywords
beadset
real
time
analysis
clinical samples
Prior art date
Application number
AT96936310T
Other languages
English (en)
Inventor
Van Chandler
R Fulton
Mark Chandler
Original Assignee
Luminex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/542,401 external-priority patent/US5736330A/en
Priority claimed from US08/540,814 external-priority patent/US5981180A/en
Application filed by Luminex Corp filed Critical Luminex Corp
Application granted granted Critical
Publication of ATE496288T1 publication Critical patent/ATE496288T1/de

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1012—Calibrating particle analysers; References therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1456—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/1012—Calibrating particle analysers; References therefor
    • G01N2015/1014—Constitution of reference particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1477—Multiparameters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486—Counting the particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1488—Methods for deciding
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/973—Simultaneous determination of more than one analyte

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Ecology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Ultra Sonic Daignosis Equipment (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
AT96936310T 1995-10-11 1996-10-10 Gleichzeitige mehrfachanalyse klinischer proben ATE496288T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/542,401 US5736330A (en) 1995-10-11 1995-10-11 Method and compositions for flow cytometric determination of DNA sequences
US08/540,814 US5981180A (en) 1995-10-11 1995-10-11 Multiplexed analysis of clinical specimens apparatus and methods
PCT/US1996/016198 WO1997014028A2 (en) 1995-10-11 1996-10-10 Multiplexed analysis of clinical specimens apparatus and method

Publications (1)

Publication Number Publication Date
ATE496288T1 true ATE496288T1 (de) 2011-02-15

Family

ID=27066528

Family Applications (1)

Application Number Title Priority Date Filing Date
AT96936310T ATE496288T1 (de) 1995-10-11 1996-10-10 Gleichzeitige mehrfachanalyse klinischer proben

Country Status (7)

Country Link
US (2) US6524793B1 (de)
EP (1) EP0852004B1 (de)
AT (1) ATE496288T1 (de)
AU (1) AU7398996A (de)
CA (1) CA2227895C (de)
DE (1) DE69638321D1 (de)
WO (1) WO1997014028A2 (de)

Families Citing this family (336)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6406848B1 (en) 1997-05-23 2002-06-18 Lynx Therapeutics, Inc. Planar arrays of microparticle-bound polynucleotides
USRE43097E1 (en) 1994-10-13 2012-01-10 Illumina, Inc. Massively parallel signature sequencing by ligation of encoded adaptors
US7041510B2 (en) 1996-04-25 2006-05-09 Bioarray Solutions Ltd. System and method for programmable illumination pattern generation
EP0907889B1 (de) 1996-04-25 2007-07-04 BioArray Solutions Ltd. Licht-regulierte, elektrokinetische zusammensetzung von partikeln an oberflächen
SE9602545L (sv) 1996-06-25 1997-12-26 Michael Mecklenburg Metod för att diskriminera komplexa biologiska prover
US20030027126A1 (en) 1997-03-14 2003-02-06 Walt David R. Methods for detecting target analytes and enzymatic reactions
US7622294B2 (en) 1997-03-14 2009-11-24 Trustees Of Tufts College Methods for detecting target analytes and enzymatic reactions
US6327410B1 (en) * 1997-03-14 2001-12-04 The Trustees Of Tufts College Target analyte sensors utilizing Microspheres
US6023540A (en) * 1997-03-14 2000-02-08 Trustees Of Tufts College Fiber optic sensor with encoded microspheres
US6406845B1 (en) 1997-05-05 2002-06-18 Trustees Of Tuft College Fiber optic biosensor for selectively detecting oligonucleotide species in a mixed fluid sample
WO1998053093A1 (en) 1997-05-23 1998-11-26 Bioarray Solutions Llc Color-encoding and in-situ interrogation of matrix-coupled chemical compounds
US5948627A (en) * 1997-05-30 1999-09-07 One Lambda Immunobead flow cytometric detection of anti-HLA panel-reactive antibody
US7348181B2 (en) * 1997-10-06 2008-03-25 Trustees Of Tufts College Self-encoding sensor with microspheres
US7115884B1 (en) 1997-10-06 2006-10-03 Trustees Of Tufts College Self-encoding fiber optic sensor
JP2003502005A (ja) * 1997-10-28 2003-01-21 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア フローサイトメトリーを用いるｄｎａ塩基ミスマッチ検出
EP1248110A3 (de) 1997-11-18 2005-01-26 Bio-Rad Laboratories, Inc. Multiplex-Zufluss-Immunotest mit magnetischen Teilchen als Festphase
US7271009B1 (en) 1997-11-18 2007-09-18 Bio-Rad Laboratories, Inc. Multi-analyte diagnostic test for thyroid disorders
CA2313047A1 (en) * 1997-12-04 1999-12-16 Nicholas Thomas Multiple assay method
US6210910B1 (en) 1998-03-02 2001-04-03 Trustees Of Tufts College Optical fiber biosensor array comprising cell populations confined to microcavities
US6455263B2 (en) * 1998-03-24 2002-09-24 Rigel Pharmaceuticals, Inc. Small molecule library screening using FACS
AU3555599A (en) 1998-04-13 1999-11-01 Luminex Corporation Liquid labeling with fluorescent microparticles
EP1090138A4 (de) * 1998-06-24 2003-01-02 Glaxo Group Ltd Nachweisverfahren für nukleotide
US7060431B2 (en) * 1998-06-24 2006-06-13 Illumina, Inc. Method of making and decoding of array sensors with microspheres
US6642062B2 (en) 1998-09-03 2003-11-04 Trellis Bioinformatics, Inc. Multihued labels
JP4533536B2 (ja) * 1998-09-03 2010-09-01 トレリス バイオサイエンス， インコーポレイテッド 複数色の標識
US6429027B1 (en) 1998-12-28 2002-08-06 Illumina, Inc. Composite arrays utilizing microspheres
US6846460B1 (en) 1999-01-29 2005-01-25 Illumina, Inc. Apparatus and method for separation of liquid phases of different density and for fluorous phase organic syntheses
US6696304B1 (en) 1999-02-24 2004-02-24 Luminex Corporation Particulate solid phase immobilized protein quantitation
GB9905807D0 (en) * 1999-03-12 1999-05-05 Amersham Pharm Biotech Uk Ltd Analysis of differential gene expression
US20060275782A1 (en) * 1999-04-20 2006-12-07 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
AU4476900A (en) * 1999-04-20 2000-11-02 Illumina, Inc. Detection of nucleic acid reactions on bead arrays
US6355431B1 (en) 1999-04-20 2002-03-12 Illumina, Inc. Detection of nucleic acid amplification reactions using bead arrays
AU4710800A (en) * 1999-05-12 2000-11-21 Axys Pharmaceuticals, Inc. Methods of software driven flow sorting for reiterative synthesis cycles
US6544732B1 (en) 1999-05-20 2003-04-08 Illumina, Inc. Encoding and decoding of array sensors utilizing nanocrystals
CA2374390A1 (en) 1999-05-20 2000-12-14 Illumina, Inc. Combinatorial decoding of random nucleic acid arrays
US8481268B2 (en) 1999-05-21 2013-07-09 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US8080380B2 (en) 1999-05-21 2011-12-20 Illumina, Inc. Use of microfluidic systems in the detection of target analytes using microsphere arrays
US6673554B1 (en) 1999-06-14 2004-01-06 Trellie Bioinformatics, Inc. Protein localization assays for toxicity and antidotes thereto
AU5764500A (en) * 1999-06-25 2001-01-31 Motorola, Inc. Novel methods and products for arrayed microsphere analysis
US6649414B1 (en) * 1999-08-17 2003-11-18 Luminex Corporation Microparticles with multiple fluorescent signals and methods of using same
CA2382157C (en) 1999-08-18 2012-04-03 Illumina, Inc. Compositions and methods for preparing oligonucleotide solutions
CA2382436C (en) 1999-08-30 2011-05-17 Illumina, Inc. Methods for improving signal detection from an array
EP1250675A2 (de) * 1999-09-15 2002-10-23 Luminex Corporation Datenbankerstellung für biochemische daten und benutzungsverfahren
AU7712400A (en) * 1999-09-23 2001-04-24 Gene Logic, Inc. Indexing populations
JP3781934B2 (ja) 1999-12-22 2006-06-07 株式会社ニチレイバイオサイエンス 酵素−タンパク質複合体
ATE418070T1 (de) * 1999-12-23 2009-01-15 Illumina Inc Dekodierung von matrixsensoren mit mikrokugeln
US6913884B2 (en) 2001-08-16 2005-07-05 Illumina, Inc. Compositions and methods for repetitive use of genomic DNA
US6812005B2 (en) 2000-02-07 2004-11-02 The Regents Of The University Of California Nucleic acid detection methods using universal priming
CA2399733C (en) 2000-02-07 2011-09-20 Illumina, Inc. Nucleic acid detection methods using universal priming
US7582420B2 (en) 2001-07-12 2009-09-01 Illumina, Inc. Multiplex nucleic acid reactions
US7361488B2 (en) 2000-02-07 2008-04-22 Illumina, Inc. Nucleic acid detection methods using universal priming
US6770441B2 (en) 2000-02-10 2004-08-03 Illumina, Inc. Array compositions and methods of making same
DE60136335D1 (de) 2000-02-16 2008-12-11 Illumina Inc Parallele genotypisierung mehrerer patientenproben
US20010026920A1 (en) * 2000-02-25 2001-10-04 Mark Chandler Internal standards and controls for multiplexed assay
AU2001249444A1 (en) * 2000-03-28 2001-10-08 The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services Methods and compositions for the simultaneous detection of multiple analytes
ES2370232T3 (es) 2000-05-04 2011-12-13 Siemens Healthcare Diagnostics Products Gmbh Procedimiento para la detección de múltiples analitos.
DE10065632A1 (de) 2000-05-12 2001-11-15 Smtech Biovision Holding Ag Ec Verfahren zum Nachweis von Polynukleotiden
WO2001085991A2 (de) * 2000-05-12 2001-11-15 Gnothis Holding Sa Verfahren zum nachweis von polynukleotiden durch fluoreszenzkorrelationsspektroskopie
US9709559B2 (en) 2000-06-21 2017-07-18 Bioarray Solutions, Ltd. Multianalyte molecular analysis using application-specific random particle arrays
US7465540B2 (en) * 2000-09-21 2008-12-16 Luminex Corporation Multiple reporter read-out for bioassays
US20030045005A1 (en) 2000-10-17 2003-03-06 Michael Seul Light-controlled electrokinetic assembly of particles near surfaces
AU2002229977A1 (en) * 2001-02-13 2002-08-28 Smartbead Technologies Limited Biochemical method and apparatus for detecting genetic characteristics
EP1360491B1 (de) * 2001-02-13 2007-04-11 Pronostics Limited Biochemisches verfahren und vorrichtung zur bestimmung von eigenschaften von proteinen
WO2002084249A2 (en) 2001-04-10 2002-10-24 The Board Of Trustees Of The Leland Stanford Junior University Therapeutic and diagnostic uses of antibody specificity profiles
US7262063B2 (en) 2001-06-21 2007-08-28 Bio Array Solutions, Ltd. Directed assembly of functional heterostructures
US7473767B2 (en) 2001-07-03 2009-01-06 The Institute For Systems Biology Methods for detection and quantification of analytes in complex mixtures
US7479630B2 (en) 2004-03-25 2009-01-20 Bandura Dmitry R Method and apparatus for flow cytometry linked with elemental analysis
US8148171B2 (en) 2001-10-09 2012-04-03 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
EP2722395B1 (de) 2001-10-15 2018-12-19 Bioarray Solutions Ltd Gemultiplexte Analyse polymorphischer Stellen durch gleichzeitige Abfrage und enzymvermittelte Detektion
US6838289B2 (en) * 2001-11-14 2005-01-04 Beckman Coulter, Inc. Analyte detection system
AU2002362013B2 (en) 2001-11-21 2008-04-24 Applied Biosystems, Llc. Digital assay
US7232691B2 (en) * 2001-11-27 2007-06-19 Los Alamos National Security, Llc Bioassay and biomolecular identification, sorting, and collection methods using magnetic microspheres
US20030109067A1 (en) 2001-12-06 2003-06-12 Immunetech, Inc. Homogeneous immunoassays for multiple allergens
US20030119073A1 (en) * 2001-12-21 2003-06-26 Stephen Quirk Sensors and methods of detection for proteinase enzymes
EP1365034A3 (de) 2002-05-21 2004-02-18 Bayer HealthCare AG Verfahren und Zusammensetzungen zur Vorhersage, Diagnose, Prognose, Prävention und Behandlung von malignen Tumoren
CA2492631C (en) * 2002-05-31 2013-03-12 Genetic Technologies Limited Maternal antibodies as fetal cell markers to identify and enrich fetal cells from maternal blood
US7190522B2 (en) * 2002-09-12 2007-03-13 Cyvera Corporation Chemical synthesis using diffraction grating-based encoded optical elements
US7164533B2 (en) 2003-01-22 2007-01-16 Cyvera Corporation Hybrid random bead/chip based microarray
US7441703B2 (en) * 2002-08-20 2008-10-28 Illumina, Inc. Optical reader for diffraction grating-based encoded optical identification elements
US7619819B2 (en) * 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7872804B2 (en) * 2002-08-20 2011-01-18 Illumina, Inc. Encoded particle having a grating with variations in the refractive index
US7900836B2 (en) * 2002-08-20 2011-03-08 Illumina, Inc. Optical reader system for substrates having an optically readable code
WO2004019276A1 (en) * 2002-08-20 2004-03-04 Cyvera Corporation Diffraction grating-based optical identification element
US7508608B2 (en) * 2004-11-17 2009-03-24 Illumina, Inc. Lithographically fabricated holographic optical identification element
US20040126875A1 (en) * 2002-09-12 2004-07-01 Putnam Martin A. Assay stick
US20050227252A1 (en) * 2002-08-20 2005-10-13 Moon John A Diffraction grating-based encoded articles for multiplexed experiments
US7901630B2 (en) * 2002-08-20 2011-03-08 Illumina, Inc. Diffraction grating-based encoded microparticle assay stick
US7923260B2 (en) 2002-08-20 2011-04-12 Illumina, Inc. Method of reading encoded particles
WO2004019277A1 (en) * 2002-08-20 2004-03-04 Cyvera Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
AU2002950953A0 (en) * 2002-08-23 2002-09-12 Genera Biosystems Pty Ltd Coded nucleic acid carriers
AU2003270726A1 (en) * 2002-09-12 2004-04-30 Cidra Corporation Diffraction grating-based encoded micro-particles for multiplexed experiments
US7092160B2 (en) * 2002-09-12 2006-08-15 Illumina, Inc. Method of manufacturing of diffraction grating-based optical identification element
US20100255603A9 (en) 2002-09-12 2010-10-07 Putnam Martin A Method and apparatus for aligning microbeads in order to interrogate the same
CA2499037A1 (en) * 2002-09-12 2004-03-25 Cyvera Corporation Method and apparatus for labelling using diffraction grating-based encoded optical identification elements
CA2498933C (en) * 2002-09-12 2012-08-28 Cyvera Corporation Method and apparatus for aligning elongated microbeads in order to interrogate the same
US7526114B2 (en) 2002-11-15 2009-04-28 Bioarray Solutions Ltd. Analysis, secure access to, and transmission of array images
WO2004065000A1 (en) 2003-01-21 2004-08-05 Illumina Inc. Chemical reaction monitor
ITMI20030339A1 (it) * 2003-02-26 2004-08-27 Pranha 50 Ltda Metodo, apparato e dispositivi per il risanamento di condotte mediante introduzione di tubi in materiale plastico.
US8394582B2 (en) 2003-03-05 2013-03-12 Genetic Technologies, Inc Identification of fetal DNA and fetal cell markers in maternal plasma or serum
US8173443B2 (en) * 2003-03-31 2012-05-08 Women's And Children's Hospital Multiplex screening for lysosomal storage disorders (LSDs)
FR2855613B1 (fr) * 2003-05-26 2005-08-19 Biocytex Procede de detection et de quantification multiplex d'analytes dans un echantillon a l'aide de microspheres
US20050053980A1 (en) 2003-06-20 2005-03-10 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20050181394A1 (en) * 2003-06-20 2005-08-18 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
US20040259100A1 (en) * 2003-06-20 2004-12-23 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
AU2003903417A0 (en) 2003-07-04 2003-07-17 Genera Biosystems Pty Ltd Multiplex detection
US7260485B2 (en) * 2003-07-18 2007-08-21 Luminex Corporation Method and systems for distinguishing between materials having similar spectra
CA2949524C (en) * 2003-07-18 2017-07-04 Bio-Rad Laboratories, Inc. System and method for multi-analyte detection
US8012768B2 (en) * 2003-07-18 2011-09-06 Bio-Rad Laboratories, Inc. System and method for multi-analyte detection
WO2005012548A2 (en) * 2003-08-01 2005-02-10 Dynal Biotech Inc. Self-hybridizing multiple target nucleic acid probes and methods of use
AU2003270759A1 (en) * 2003-08-04 2005-03-07 Emory University Porous materials embedded with nanospecies
US7692773B2 (en) * 2003-08-05 2010-04-06 Luminex Corporation Light emitting diode based measurement systems
US7069191B1 (en) 2003-08-06 2006-06-27 Luminex Corporation Methods for reducing the susceptibility of a peak search to signal noise
KR101166180B1 (ko) * 2003-08-13 2012-07-18 루미넥스 코포레이션 유세포 분석기식 측정 시스템의 하나 이상의 파라미터의 제어 방법
US20060057729A1 (en) * 2003-09-12 2006-03-16 Illumina, Inc. Diffraction grating-based encoded element having a substance disposed thereon
GB0321508D0 (en) * 2003-09-13 2003-10-15 Secr Defence Antibody-based identification of bacterial phenotypes
WO2005029078A1 (en) * 2003-09-17 2005-03-31 Guava Technologies, Inc. Compositions and methods for analysis of target analytes
WO2005031305A2 (en) 2003-09-22 2005-04-07 Bioarray Solutions, Ltd. Surface immobilized polyelectrolyte with multiple functional groups capable of covalently bonding to biomolecules
EP1522594A3 (de) 2003-10-06 2005-06-22 Bayer HealthCare AG Verfahren und kit zur untersuchung von krebs
JP2007521017A (ja) 2003-10-28 2007-08-02 バイオアレイ ソリューションズ リミテッド 固定化捕捉プローブを用いる遺伝子発現分析法の最適化
US20050136414A1 (en) * 2003-12-23 2005-06-23 Kevin Gunderson Methods and compositions for making locus-specific arrays
WO2005071412A2 (en) 2004-01-09 2005-08-04 Applera Corporation Phosphor particle coded beads
CA2553025A1 (en) * 2004-01-14 2005-07-28 Luminex Corporation Methods and systems for dynamic range expansion
WO2005071389A1 (en) 2004-01-14 2005-08-04 Luminex Corporation Methods for altering one or more parameters of a measurement system
US7433123B2 (en) * 2004-02-19 2008-10-07 Illumina, Inc. Optical identification element having non-waveguide photosensitive substrate with diffraction grating therein
US7229778B2 (en) 2004-02-26 2007-06-12 The Procter & Gamble Company Methods for determining the relative benefits and/or evaluating quantitative changes of products on epithelial tissue
US20050266432A1 (en) * 2004-02-26 2005-12-01 Illumina, Inc. Haplotype markers for diagnosing susceptibility to immunological conditions
US20050221363A1 (en) * 2004-04-01 2005-10-06 Rules-Based Medicine, Inc. Universal shotgun assay
US7702466B1 (en) 2004-06-29 2010-04-20 Illumina, Inc. Systems and methods for selection of nucleic acid sequence probes
US7635563B2 (en) * 2004-06-30 2009-12-22 Massachusetts Institute Of Technology High throughput methods relating to microRNA expression analysis
US7848889B2 (en) 2004-08-02 2010-12-07 Bioarray Solutions, Ltd. Automated analysis of multiplexed probe-target interaction patterns: pattern matching and allele identification
CA2583531A1 (en) 2004-10-12 2006-04-27 Luminex Corporation Methods for forming dyed microspheres and populations of dyed microspheres
JP4988578B2 (ja) * 2004-10-12 2012-08-01 ルミネックス コーポレーション ミクロスフェアの表面特性を変化させるための方法
US8088629B1 (en) 2004-10-12 2012-01-03 Luminex Corporation Methods for forming dyed microspheres and populations of microspheres
EP1820001A1 (de) * 2004-11-12 2007-08-22 Luminex Corporation Verfahren und systeme zur positionierung von mikrokugeln für die bilderzeugung
US7604173B2 (en) * 2004-11-16 2009-10-20 Illumina, Inc. Holographically encoded elements for microarray and other tagging labeling applications, and method and apparatus for making and reading the same
WO2006055736A1 (en) * 2004-11-16 2006-05-26 Illumina, Inc. And methods and apparatus for reading coded microbeads
CA2589195A1 (en) * 2004-11-29 2006-06-01 Perkinelmer Las, Inc. Particle-based multiplex assay for identifying glycosylation
CA2589912C (en) 2004-12-10 2019-03-05 Genera Biosystems Pty Ltd A beadset and method for detecting human papilloma virus (hpv)
KR20070095306A (ko) * 2004-12-17 2007-09-28 루미넥스 코포레이션 시스템, 조명 서브 시스템 및 형광원에 의해 방출된 형광을증가하는 방법
US20060160102A1 (en) 2005-01-18 2006-07-20 Hossein Fakhrai-Rad Identification of rare alleles by enzymatic enrichment of mismatched heteroduplexes
DE602006015908D1 (de) 2005-01-20 2010-09-16 Luminex Corp Mikrokugeln mit fluoreszente und magnetische eigenschaften
CA2495138C (en) * 2005-01-20 2012-10-23 Alison Jane Basile Multiplexed analysis for determining a serodiagnosis of viral infection
JP2008538609A (ja) * 2005-04-20 2008-10-30 ベクトン・ディキンソン・アンド・カンパニー マルチプレックスマイクロ粒子システム
JP4520361B2 (ja) * 2005-05-25 2010-08-04 日立ソフトウエアエンジニアリング株式会社 プローブビーズの品質検査方法
CA2611671C (en) 2005-06-15 2013-10-08 Callida Genomics, Inc. Single molecule arrays for genetic and chemical analysis
US20070043510A1 (en) * 2005-08-19 2007-02-22 Beckman Coulter, Inc. Assay system
US7504235B2 (en) 2005-08-31 2009-03-17 Kimberly-Clark Worldwide, Inc. Enzyme detection technique
EP4071458A1 (de) * 2005-09-21 2022-10-12 Luminex Corporation Verfahren und systeme für die bilddatenverarbeitung
GB2432419A (en) 2005-11-16 2007-05-23 Agency Science Tech & Res Influenza A virus detection method
US7623624B2 (en) * 2005-11-22 2009-11-24 Illumina, Inc. Method and apparatus for labeling using optical identification elements characterized by X-ray diffraction
EP1969372A4 (de) * 2005-12-23 2009-04-22 Perkinelmer Las Inc Verfahren und zusammensetzungen zum nachweis enzymatischer aktivität
CA2640385C (en) 2005-12-23 2014-07-15 Nanostring Technologies, Inc. Nanoreporters and methods of manufacturing and use thereof
WO2007075891A2 (en) * 2005-12-23 2007-07-05 Perkinelmer Las, Inc. Multiplex assays using magnetic and non-magnetic particles
WO2008018905A2 (en) * 2006-01-17 2008-02-14 Cellumen, Inc. Method for predicting biological systems responses
US8309025B1 (en) 2006-01-26 2012-11-13 Luminex Corporation Methods and systems for determining composition and completion of an experiment
US20070190560A1 (en) 2006-02-13 2007-08-16 Olga Ornatsky Element-tagged olignucleotide gene expression analysis
CA2571904A1 (en) * 2006-02-15 2007-08-15 Fio Corporation System and method of detecting pathogens
US20070207513A1 (en) * 2006-03-03 2007-09-06 Luminex Corporation Methods, Products, and Kits for Identifying an Analyte in a Sample
US7914988B1 (en) * 2006-03-31 2011-03-29 Illumina, Inc. Gene expression profiles to predict relapse of prostate cancer
US8758989B2 (en) 2006-04-06 2014-06-24 Kimberly-Clark Worldwide, Inc. Enzymatic detection techniques
US8124943B1 (en) 2006-04-06 2012-02-28 Lugade Ananda G Methods and systems for altering fluorescent intensities of a plurality of particles
US7830575B2 (en) * 2006-04-10 2010-11-09 Illumina, Inc. Optical scanner with improved scan time
CN101421414A (zh) * 2006-04-17 2009-04-29 卢米尼克斯股份有限公司 用来测定激酶的活性的方法、颗粒和试剂盒
CN101484806A (zh) 2006-05-17 2009-07-15 协乐民公司 一种对组织进行自动分析的方法
CN101454653B (zh) * 2006-05-17 2013-01-16 卢米尼克斯股份有限公司 用于分析荧光标记颗粒的基于芯片的流式细胞器类系统
EP2038655A2 (de) 2006-06-02 2009-03-25 Luminex Corporation Systeme und verfahren zur durchführung von messungen eines oder mehrerer materialien
US8296088B2 (en) 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
EP2057465A4 (de) 2006-08-09 2010-04-21 Homestead Clinical Corp Organspezifische proteine und anwendungsverfahren dafür
US8283624B2 (en) 2006-08-15 2012-10-09 Dvs Sciences Inc. Apparatus and method for elemental analysis of particles by mass spectrometry
US7501290B2 (en) * 2006-09-13 2009-03-10 Hanley Brian P Intraplexing method for improving precision of suspended microarray assays
US9465036B2 (en) 2006-11-02 2016-10-11 Fluidigm Canada Inc. Particles containing detectable elemental code
US8062609B2 (en) 2006-11-10 2011-11-22 Luminex Corporation Flow cytometer and fluidic line assembly with multiple injection needles
EP2095119A2 (de) * 2006-11-10 2009-09-02 Cellumen, Inc. Biosensoren für protein-protein-interaktion und verfahren zu ihrer verwendung
SG143090A1 (en) * 2006-11-27 2008-06-27 Agency Science Tech & Res Influenza b virus detection method and kit therefor
BRPI0721095B1 (pt) 2006-12-13 2015-09-29 Luminex Corp Sistemas e métodos para a análise multíplex de pcr em tempo real
US7897360B2 (en) 2006-12-15 2011-03-01 Kimberly-Clark Worldwide, Inc. Enzyme detection techniques
CA2580589C (en) * 2006-12-19 2016-08-09 Fio Corporation Microfluidic detection system
US8003312B2 (en) * 2007-02-16 2011-08-23 The Board Of Trustees Of The Leland Stanford Junior University Multiplex cellular assays using detectable cell barcodes
US20080241831A1 (en) * 2007-03-28 2008-10-02 Jian-Bing Fan Methods for detecting small RNA species
US8360321B2 (en) 2007-04-02 2013-01-29 Fio Corporation System and method of deconvolving multiplexed fluorescence spectral signals generated by quantum dot optical coding technology
JP2010530912A (ja) 2007-06-22 2010-09-16 フィオ コーポレイション 量子ドットをドープしたポリマーマイクロビーズの製造システム及び方法
EP2395113A1 (de) 2007-06-29 2011-12-14 Population Genetics Technologies Ltd. Verfahren und Zusammensetzungen zur Isolierung von Nukleinsäuresequenzvarianten
WO2009006739A1 (en) * 2007-07-09 2009-01-15 Fio Corporation Systems and methods for enhancing fluorescent detection of target molecules in a test sample
WO2009012585A1 (en) * 2007-07-23 2009-01-29 Fio Corporation A method and system for collating, storing, analyzing and enabling access to collected and analyzed data associated with biological and environmental test subjects
US20090029347A1 (en) * 2007-07-27 2009-01-29 Thornthwaite Jerry T Method for Identifying Multiple Analytes Using Flow Cytometry
CA2699319A1 (en) 2007-09-17 2009-03-26 Luminex Corporation Systems, storage mediums, and methods for identifying particles in flow
CN101861203B (zh) 2007-10-12 2014-01-22 Fio公司 用于形成浓缩体积的微珠的流动聚焦方法和系统以及形成的微珠
US20090170214A1 (en) * 2007-12-27 2009-07-02 Luminex Corporation Luminescent Reporter Modality for Analyzing an Assay
WO2009091643A1 (en) 2008-01-07 2009-07-23 Luminex Corporation Isolation and enumeration of cells from a complex sample matrix
CN101939648B (zh) * 2008-01-07 2013-09-04 卢米耐克斯公司 生物靶标的免疫磁性捕获和成像
EP2706121A1 (de) 2008-03-13 2014-03-12 PerkinElmer Health Sciences, Inc. Enzymatische Substrat Bauelementen zum Mehrfachdetektionssysteme
CN102066899A (zh) * 2008-04-23 2011-05-18 卢米耐克斯公司 建立针对生物来源之起始材料中多种分析物的标准品的方法
WO2009155704A1 (en) 2008-06-25 2009-12-30 Fio Corporation Bio-threat alert system
CA2730982C (en) * 2008-07-17 2017-11-14 Luminex Corporation Methods, storage mediums, and systems for configuring classification regions within a classification matrix of an analysis system and for classifying particles of an assay
JP5836803B2 (ja) 2008-08-14 2015-12-24 ナノストリング テクノロジーズ， インコーポレイテッド 安定したナノレポーター
EP2326727B1 (de) * 2008-08-15 2016-05-04 Litmus Rapid-B LLC Auf durchflusszytometer basierende systeme und verfahren für den nachweis von mikroben
BRPI0917839A2 (pt) 2008-08-29 2015-11-24 Fio Corp dispositivo de teste de diagnóstico portátil de uso único, e um sistema associado e método para teste de amostras de teste ambientais e biológicas
FR2935802B1 (fr) * 2008-09-05 2012-12-28 Horiba Abx Sas Procede et dispositif de classification, de visualisation et d'exploration de donnees biologiques
WO2010048337A2 (en) 2008-10-22 2010-04-29 Illumina, Inc. Preservation of information related to genomic dna methylation
WO2010054385A2 (en) 2008-11-10 2010-05-14 Luminex Corporation Method and system for manufacture and use of macroporous beads in a multiplex assay
CA2749660C (en) 2009-01-13 2017-10-31 Fio Corporation A handheld diagnostic test device and method for use with an electronic device and a test cartridge in a rapid diagnostic test
US20100220315A1 (en) * 2009-02-27 2010-09-02 Beckman Coulter, Inc. Stabilized Optical System for Flow Cytometry
US20110046919A1 (en) * 2009-03-02 2011-02-24 Juliesta Elaine Sylvester Method for accurate measurement of enzyme activities
US20100261292A1 (en) 2009-04-10 2010-10-14 Meso Scale Technologies, Llc Methods for Conducting Assays
AU2010239131A1 (en) 2009-04-21 2011-11-17 Genetic Technologies Limited Methods for obtaining fetal genetic material
US8343775B2 (en) * 2009-05-06 2013-01-01 Hanley Brian P Method and device for affinity differential intraplexing
EP2290102A1 (de) 2009-07-08 2011-03-02 Administración General De La Communidad Autónoma De Euskadi Verfahren zur Diagnose von multipler Sklerose basierend auf dem MikroRNA-Expressionsprofil
JP5954876B2 (ja) 2009-10-13 2016-07-20 ナノストリング テクノロジーズ， インコーポレイテッド ナノレポーターによるタンパク質の検出
GB2475226A (en) 2009-11-03 2011-05-18 Genetic Analysis As Universal Prokaryote 16S ribosome PCR primer pair
EP2336769A1 (de) 2009-12-18 2011-06-22 F. Hoffmann-La Roche AG Assay zur Unterscheidung zwischen rheumatischen und nicht rheumatischen Leiden
WO2011100541A2 (en) 2010-02-11 2011-08-18 Nanostring Technologies, Inc. Compositions and methods for the detection of small rnas
GB201002627D0 (en) 2010-02-16 2010-03-31 Loxbridge Res Llp Aptamer based analyte detection method
WO2011106314A2 (en) 2010-02-25 2011-09-01 Advanced Liquid Logic, Inc. Method of making nucleic acid libraries
WO2011127390A2 (en) 2010-04-09 2011-10-13 Luminex Corporation Magnetic separation device
AU2011243039B2 (en) 2010-04-16 2015-01-15 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services, Centers For Disease Control And Prevention Real time PCR assay for detection of bacterial respiratory pathogens
US9228240B2 (en) 2010-06-03 2016-01-05 California Institute Of Technology Methods for detecting and quantifying viable bacterial endo-spores
US8274656B2 (en) 2010-06-30 2012-09-25 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device
US8767069B2 (en) 2010-06-30 2014-07-01 Luminex Corporation Apparatus, system, and method for increasing measurement accuracy in a particle imaging device using light distribution
EP4300100A3 (de) 2010-10-14 2024-09-04 Meso Scale Technologies, LLC Reagenzienlagerung in einer assay-vorrichtung
US9115408B2 (en) 2010-10-26 2015-08-25 The United States Of America As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention Rapid Salmonella serotyping assay
US9163287B2 (en) 2010-10-26 2015-10-20 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services, Centers For Disease Control And Prevention Rapid salmonella serotyping assay
EP3193180A1 (de) 2010-11-17 2017-07-19 Advanced Liquid Logic, Inc. Kapazitätsdetektion in einem tröpfchenaktuator
GB201021397D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Diagnosis of Crohn's disease
GB201021399D0 (en) 2010-12-16 2011-01-26 Genetic Analysis As Oligonucleotide probe set and methods of microbiota profiling
CN103460043A (zh) * 2011-01-05 2013-12-18 宙斯科技公司 诊断方法
GB201102693D0 (en) 2011-02-16 2011-03-30 Genetic Analysis As Method for identifying neonates at risk for necrotizing enterocolitis
AU2012229102B2 (en) 2011-03-17 2016-02-04 Cernostics, Inc. Systems and compositions for diagnosing Barrett's esophagus and methods of using the same
US9758834B2 (en) 2011-03-28 2017-09-12 Nanostring Technologies, Inc. Compositions and methods for diagnosing cancer
US20140174926A1 (en) 2011-05-02 2014-06-26 Advanced Liquid Logic, Inc. Molecular diagnostics platform
US9188615B2 (en) 2011-05-09 2015-11-17 Advanced Liquid Logic, Inc. Microfluidic feedback using impedance detection
US9140635B2 (en) 2011-05-10 2015-09-22 Advanced Liquid Logic, Inc. Assay for measuring enzymatic modification of a substrate by a glycoprotein having enzymatic activity
EP2546358A1 (de) 2011-07-15 2013-01-16 Laboratorios Del. Dr. Esteve, S.A. Verfahren und Reagenzien zur effizienten Steuerung des HIV-Fortschritts
EP2761032B1 (de) 2011-09-29 2017-07-19 Luminex Corporation Hydrolysesonden
US8859996B2 (en) 2011-10-18 2014-10-14 Luminex Corporation Methods and systems for image data processing
WO2013070990A1 (en) 2011-11-11 2013-05-16 Glezer Eli N Co-binder assisted assay methods
US10731199B2 (en) 2011-11-21 2020-08-04 Advanced Liquid Logic, Inc. Glucose-6-phosphate dehydrogenase assays
MX349562B (es) 2011-12-09 2017-08-02 Pasteur Institut Ensayo de inmuno deteccion multiplex.
WO2013119763A1 (en) 2012-02-07 2013-08-15 Intuitive Biosciences, Inc. Mycobacterium tuberculosis specific peptides for detection of infection or immunization in non-human primates
US20130274125A1 (en) * 2012-04-16 2013-10-17 Bio-Rad Laboratories Inc. Multiplex immunoassay for rheumatoid arthritis and other autoimmune diseases
US9012022B2 (en) 2012-06-08 2015-04-21 Illumina, Inc. Polymer coatings
ES2434853B1 (es) 2012-06-12 2014-09-30 Fundación Centro Nacional De Investigaciones Cardiovasculares Carlos Iii Marcador molecular de potencia terapéutica de células madre mesenquimales humanas y sus usos
US9394574B2 (en) 2012-06-12 2016-07-19 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Methods for detecting Legionella nucleic acids in a sample
CN104541152B (zh) 2012-06-15 2017-08-25 卢米尼克斯股份有限公司 使用拟合选择标准的高斯残差的图像归一化装置、系统和方法
EP2972353B1 (de) 2013-03-11 2023-02-22 Meso Scale Technologies, LLC Verbesserte verfahren zur durchführung von multiplex-assays
AU2014248759B2 (en) 2013-03-13 2020-02-27 Meso Scale Technologies, Llc. Improved assay methods
US10114015B2 (en) 2013-03-13 2018-10-30 Meso Scale Technologies, Llc. Assay methods
US9921224B2 (en) 2013-03-14 2018-03-20 Children's Medical Center Corporation Use of CD36 to identify cancer subjects for treatment
CN105209532B (zh) 2013-03-15 2017-11-28 路博润先进材料公司 不含重金属的cpvc组合物
EP2970356B1 (de) 2013-03-15 2018-05-30 Illumina Cambridge Limited Modifizierte nucleotide und nucleoside
US20150064153A1 (en) 2013-03-15 2015-03-05 The Trustees Of Princeton University High efficiency microfluidic purification of stem cells to improve transplants
EP2971287B1 (de) 2013-03-15 2019-08-14 GPB Scientific, LLC Mikrofluidische on-chip-verarbeitung von partikeln
CN105247042B (zh) 2013-03-15 2021-06-11 普林斯顿大学理事会 用于高通量纯化的方法和设备
CN111537426A (zh) * 2013-03-15 2020-08-14 贝克曼考尔特公司 用于设计流式细胞术中的面板的系统和方法
CA2906839A1 (en) 2013-03-15 2014-09-18 Perkinelmer Health Sciences, Inc. Compounds and methods relating to testing for lysosomal storage disorders
EP2787349A1 (de) 2013-04-03 2014-10-08 Affiris AG Verfahren zur Erkennung von proteinopathiespezifischen Antikörpern in einer biologischen Probe
EP2787348A1 (de) 2013-04-03 2014-10-08 Affiris AG Verfahren zur Erkennung von aSyn-spezifischen Antikörpern in einer biologischen Probe
EP2787347A1 (de) * 2013-04-03 2014-10-08 Affiris AG Verfahren zur Erkennung von Aß-spezifischen Antikörpern in einer biologischen Probe
CN103235120B (zh) * 2013-04-22 2014-12-31 苏州华益美生物科技有限公司 一种复合检测戊型肝炎病毒抗体谱的试剂盒及其应用
ES2523016B1 (es) 2013-05-20 2015-09-09 3P Biopharmaceuticals Vectores alfavirales y líneas celulares para la producción de proteínas recombinantes
US20140378327A1 (en) 2013-06-19 2014-12-25 Luminex Corporation Real-time multiplexed hydrolysis probe assay using spectrally identifiable microspheres
AU2014284584B2 (en) 2013-07-01 2019-08-01 Illumina, Inc. Catalyst-free surface functionalization and polymer grafting
KR102398399B1 (ko) 2013-08-09 2022-05-16 루미넥스 코포레이션 핵산 에세이에서의 향상된 용융 식별 및 복합화를 위한 프로브
CN111957453B (zh) 2013-08-13 2022-08-19 先进流体逻辑公司 使用作为流体输入的接通致动器储液器来提高液滴计量的准确度和精度的方法
WO2015026873A1 (en) 2013-08-19 2015-02-26 Singular Bio, Inc. Assays for single molecule detection and use thereof
AU2014312043A1 (en) 2013-08-30 2016-02-25 Illumina France Manipulation of droplets on hydrophilic or variegated-hydrophilic surfaces
IL284969B (en) 2013-10-21 2022-07-01 Dyax Corp Diagnosis and treatment of autoimmune diseases
US10682829B2 (en) 2013-12-19 2020-06-16 Illumina, Inc. Substrates comprising nano-patterning surfaces and methods of preparing thereof
CN112322735A (zh) 2014-01-16 2021-02-05 启迪公司 用于前列腺癌复发的预后的基因表达面板
EP3134735A4 (de) 2014-04-24 2018-06-20 Immusant Inc. Verfahren zur gewinnung antigenspezifischer t-zellen
EP3137601B1 (de) 2014-04-29 2020-04-08 Illumina, Inc. Multiplexierte einzelzellengenexpressionsanalyse mittels vorlagenwechsel und tagmentation
JP6695280B2 (ja) 2014-05-15 2020-05-20 メソ スケール テクノロジーズ エルエルシー 改善されたアッセイ方法
GB201414098D0 (en) 2014-08-08 2014-09-24 Illumina Cambridge Ltd Modified nucleotide linkers
CN106715720B (zh) 2014-08-11 2021-08-13 卢米耐克斯公司 用于在核酸测定中改善解链分辨和多重性的探针
EP3183577B1 (de) 2014-08-21 2020-08-19 Illumina Cambridge Limited Reversible oberflächenfunktionalisierung
US20160097082A1 (en) 2014-09-23 2016-04-07 Ohmx Corporation Prostate specific antigen proteolytic activity for clinical use
WO2016061509A1 (en) 2014-10-17 2016-04-21 The Broad Institute, Inc. Compositions and methods of treatng muscular dystrophy
ES2905706T3 (es) 2014-10-31 2022-04-11 Illumina Cambridge Ltd Polímeros y recubrimientos de copolímeros de ADN
CA2968422A1 (en) 2014-11-21 2016-05-26 Immusant, Inc. Peptides for use in treatment and diagnosis of type 1 diabetes
CN107847930B (zh) 2015-03-20 2020-06-30 亿明达股份有限公司 在竖直或大致竖直的位置中使用的流体盒
CA2992492A1 (en) 2015-07-17 2017-01-26 Nanostring Technologies, Inc. Simultaneous quantification of gene expression in a user-defined region of a cross-sectioned tissue
ES2975361T3 (es) 2015-07-17 2024-07-04 Nanostring Technologies Inc Cuantificación simultánea de una pluralidad de proteínas en una región definida por el usuario de un tejido seccionado transversalmente
WO2017015018A1 (en) 2015-07-17 2017-01-26 Illumina, Inc. Polymer sheets for sequencing applications
US10976232B2 (en) 2015-08-24 2021-04-13 Gpb Scientific, Inc. Methods and devices for multi-step cell purification and concentration
JP6743150B2 (ja) 2015-08-28 2020-08-19 イルミナ インコーポレイテッド 単一細胞の核酸配列分析
WO2017091658A1 (en) 2015-11-25 2017-06-01 Cernostics, Inc. Methods of predicting progression of barrett's esophagus
CN109312396A (zh) 2016-04-07 2019-02-05 伊鲁米那股份有限公司 用于构建标准化核酸文库的方法和系统
EP3458913B1 (de) 2016-05-18 2020-12-23 Illumina, Inc. Selbstassemblierte strukturierung mit gemusterten hydrophoben oberflächen
US20170336397A1 (en) 2016-05-19 2017-11-23 Roche Molecular Systems, Inc. RFID Detection Systems And Methods
US11448648B2 (en) 2016-11-11 2022-09-20 Ascendant Diagnostics, LLC Compositions and methods for diagnosing and differentiating systemic juvenile idiopathic arthritis and Kawasaki disease
CN110225980B (zh) 2016-11-21 2023-01-06 纳米线科技公司 化学组合物及其使用方法
US20200271657A1 (en) 2017-10-04 2020-08-27 Opko Pharmaceuticals, Llc Articles and methods directed to personalized therapy of cancer
EP3490237A1 (de) 2017-11-23 2019-05-29 Viramed Biotech AG Vorrichtung und verfahren zur parallelen auswertung mehrerer testflächen
KR102653725B1 (ko) 2018-01-29 2024-04-01 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 핵산 증폭을 위한 방법
CN112154216A (zh) 2018-02-12 2020-12-29 纳米线科技公司 生物分子探针以及检测基因和蛋白表达的方法
FI3756009T3 (fi) 2018-02-23 2023-12-01 Meso Scale Technologies Llc Menetelmiä antigeeniä sitovien molekyylien seulontaan normalisoimalla antigeeniä sitovan molekyylin pitoisuus
CN112703255A (zh) 2018-05-14 2021-04-23 纳米线科技公司 化学组合物及其使用方法
US20210389304A1 (en) 2018-05-17 2021-12-16 Meso Scale Technologies, Llc. Methods for isolating surface marker displaying agents
US10936163B2 (en) 2018-07-17 2021-03-02 Methodical Mind, Llc. Graphical user interface system
US11929171B2 (en) 2018-10-18 2024-03-12 The Board Of Trustees Of The Leland Stanford Junior University Methods for evaluation and treatment of glycemic dysregulation and atherosclerotic cardiovascular disease and applications thereof
US20210382043A1 (en) 2018-10-23 2021-12-09 Meso Scale Technologies, Llc. Methods for isolating surface marker displaying agents
US11293061B2 (en) 2018-12-26 2022-04-05 Illumina Cambridge Limited Sequencing methods using nucleotides with 3′ AOM blocking group
US20220099661A1 (en) 2019-03-01 2022-03-31 Meso Scale Technologies, Llc. Electrochemiluminescent labeled probes for use in immunoassay methods, methods using such and kits comprising same
US11421271B2 (en) 2019-03-28 2022-08-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing using photoswitchable labels
AU2020389779A1 (en) 2019-11-27 2022-05-26 Illumina Cambridge Limited Cyclooctatetraene containing dyes and compositions
BR112022019541A2 (pt) 2020-03-30 2022-11-16 Illumina Inc Métodos e composições para preparação de bibliotecas de ácido nucleico
CN115867560A (zh) 2020-06-22 2023-03-28 伊鲁米纳剑桥有限公司 具有3’缩醛封端基团的核苷与核苷酸
WO2022020234A2 (en) * 2020-07-20 2022-01-27 Bio-Rad Laboratories, Inc. Immunoassay for sars-cov-2 neutralizing antibodies and materials therefor
US11981964B2 (en) 2020-07-28 2024-05-14 Illumina Cambridge Limited Substituted coumarin dyes and uses as fluorescent labels
US20230349920A1 (en) 2020-09-04 2023-11-02 Meso Scale Technologies, Llc. Methods for isolating central nervous system surface marker displaying agents
US20220195517A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Long stokes shift chromenoquinoline dyes and uses in sequencing applications
US20220195516A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Methods, systems and compositions for nucleic acid sequencing
US20220195196A1 (en) 2020-12-17 2022-06-23 Illumina Cambridge Limited Alkylpyridinium coumarin dyes and uses in sequencing applications
US20220195518A1 (en) 2020-12-22 2022-06-23 Illumina Cambridge Limited Methods and compositions for nucleic acid sequencing
WO2022150711A1 (en) 2021-01-11 2022-07-14 Meso Scale Technologies, Llc. Assay system calibration systems and methods
CA3206950A1 (en) * 2021-01-29 2022-08-04 Flowmetric Life Sciences, Inc. Detecting sars-cov-2 and other infective agents
EP4330672A1 (de) 2021-04-26 2024-03-06 Meso Scale Technologies, LLC. Verfahren zur isolierung und analyse eines zielanalyts, das von einem oberflächenmarker-anzeigemittel eingekapselt ist
AU2022269804A1 (en) 2021-05-05 2023-11-02 Illumina Cambridge Limited Fluorescent dyes containing bis-boron fused heterocycles and uses in sequencing
AU2022277632A1 (en) 2021-05-20 2023-11-09 Illumina Cambridge Limited Compositions and methods for sequencing by synthesis
WO2022265994A1 (en) 2021-06-15 2022-12-22 Illumina, Inc. Hydrogel-free surface functionalization for sequencing
JP2024533947A (ja) 2021-07-21 2024-09-18 メソディカル マインド，エルエルシー． グラフィカルユーザインターフェースシステムガイドモジュール
CN117813391A (zh) 2021-07-23 2024-04-02 因美纳有限公司 制备用于dna测序的基底表面的方法
US20230304086A1 (en) 2022-03-28 2023-09-28 Illumina Cambridge Limited Labeled avidin and methods for sequencing
US20230314322A1 (en) 2022-03-29 2023-10-05 Illumina, Inc. Systems and methods of sequencing polynucleotides
WO2023212315A2 (en) 2022-04-29 2023-11-02 Meso Scale Technologies, Llc. Methods for detecting and isolating extracellular vesicles
WO2023232829A1 (en) 2022-05-31 2023-12-07 Illumina, Inc Compositions and methods for nucleic acid sequencing
US20230416279A1 (en) 2022-06-28 2023-12-28 Illumina Cambridge Limited Fluorescent dyes containing fused tetracyclic bis-boron heterocycle and uses in sequencing
WO2024039516A1 (en) 2022-08-19 2024-02-22 Illumina, Inc. Third dna base pair site-specific dna detection
WO2024068889A2 (en) 2022-09-30 2024-04-04 Illumina, Inc. Compositions and methods for reducing photo damage during sequencing
WO2024137774A1 (en) 2022-12-22 2024-06-27 Illumina, Inc. Palladium catalyst compositions and methods for sequencing by synthesis
AU2023409138A1 (en) 2022-12-22 2024-10-03 Illumina, Inc. Transition-metal catalyst compositions and methods for sequencing by synthesis
US20240271206A1 (en) 2022-12-27 2024-08-15 Illumina, Inc. Methods of sequencing using 3' allyl blocked nucleotides
US20240241620A1 (en) 2023-01-09 2024-07-18 Methodical Mind, Llc Graphical user interface system for quality control
US20240266044A1 (en) 2023-01-25 2024-08-08 Methodical Mind, Llc Laboratory coordination devices, methods, and systems
US20240327910A1 (en) 2023-03-29 2024-10-03 Illumina, Inc. Naphthalimide dyes and uses in nucleic acid sequencing
US20240327909A1 (en) 2023-03-30 2024-10-03 Illumina, Inc. Compositions and methods for nucleic acid sequencing
CN116794313B (zh) * 2023-08-18 2023-11-03 江西赛基生物技术有限公司 基于流式细胞仪同时检测三项肿瘤标志物的试剂盒及方法

Family Cites Families (88)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4166105A (en) 1973-07-30 1979-08-28 Block Engineering, Inc. Dye tagged reagent
GB1451669A (en) 1974-01-02 1976-10-06 Radiochemical Centre Ltd Protein staining
US4108972A (en) 1974-03-15 1978-08-22 Dreyer William J Immunological reagent employing radioactive and other tracers
US3959650A (en) 1974-08-26 1976-05-25 Intelcom Rad Tech Method for detecting and identifying allergy
SE7412164L (sv) 1974-09-27 1976-03-29 Pharmacia Ab Medel for intravaskuler administrering
US3952091A (en) 1974-10-23 1976-04-20 Hoffmann-La Roche Inc. Simultaneous multiple radioimmunoassay
US4169137A (en) 1974-12-20 1979-09-25 Block Engineering, Inc. Antigen detecting reagents
US4075462A (en) * 1975-01-08 1978-02-21 William Guy Rowe Particle analyzer apparatus employing light-sensitive electronic detector array
US4010250A (en) 1975-03-06 1977-03-01 The United States Of America As Represented By The Secretary Of The Navy Radioactive iodine (125I) labeling of latex particles
US4166102A (en) 1975-04-07 1979-08-28 Becton, Dickinson And Company Immobilized immunoadsorbent
US4018884A (en) 1975-06-26 1977-04-19 Hoffmann-La Roche Inc. Fluorogenic materials and labeling techniques
US4341957A (en) 1975-11-26 1982-07-27 Analytical Radiation Corporation Fluorescent antibody composition for immunofluorometric assay
US4317810A (en) 1975-09-29 1982-03-02 Cordis Laboratories, Inc. Waffle-like matrix for immunoassay and preparation thereof
US4201763A (en) 1975-10-09 1980-05-06 Bio-Rad Laboratories, Inc. Solid phase immunofluorescent assay method
US4113433A (en) 1975-12-15 1978-09-12 Gyaneshwar Prasad Khare Radioimmunoassay of hormones and metabolites in blood serum and plasma
US4028056A (en) 1976-04-20 1977-06-07 Technicon Instruments Corporation Substance separation technique
GB1582956A (en) 1976-07-30 1981-01-21 Ici Ltd Composite magnetic particles
US4108974A (en) 1976-08-27 1978-08-22 Bio-Rad Laboratories, Inc. Radioimmunoassay for thyroid hormone
US4090850A (en) 1976-11-01 1978-05-23 E. R. Squibb & Sons, Inc. Apparatus for use in radioimmunoassays
US4088746A (en) 1976-11-11 1978-05-09 Bio-Rad Laboratories, Inc. Radioimmunoassay for thyroid-stimulating hormone (TSH)
US4182750A (en) 1977-04-21 1980-01-08 Sullivan Thomas E Bloodcompatible functional polymers
DE2720704C2 (de) 1977-05-07 1986-09-25 Behringwerke Ag, 3550 Marburg Neues Glycoprotein, Verfahren zu seiner Herstellung und seine Verwendung
US4115535A (en) 1977-06-22 1978-09-19 General Electric Company Diagnostic method employing a mixture of normally separable protein-coated particles
US4219335A (en) 1978-09-18 1980-08-26 E. I. Du Pont De Nemours And Company Immunochemical testing using tagged reagents
US4184849A (en) 1977-12-05 1980-01-22 Technicon Instruments Corporation Mixed agglutination
US4231750A (en) 1977-12-13 1980-11-04 Diagnostic Reagents, Inc. Methods for performing chemical assays using fluorescence and photon counting
US4283382A (en) 1977-12-28 1981-08-11 Eastman Kodak Company Fluorescent labels comprising rare earth chelates
US4225783A (en) 1978-07-24 1980-09-30 Abbott Laboratories Determination of microbial cells in aqueous samples
US4302536A (en) 1978-08-15 1981-11-24 Longenecker Robert W Colorimetric immunoassay process
US4244940A (en) 1978-09-05 1981-01-13 Bio-Rad Laboratories, Inc. Single-incubation two-site immunoassay
US4259313A (en) 1978-10-18 1981-03-31 Eastman Kodak Company Fluorescent labels
US4342739A (en) 1979-01-09 1982-08-03 Fuji Photo Film Co., Ltd. Novel material for immunological assay of biochemical components and a process for the determination of said components
US4278653A (en) 1979-02-01 1981-07-14 New England Nuclear Corporation Methods and kits for double antibody immunoassay providing a colored pellet for easy visualization
US4254096A (en) 1979-10-04 1981-03-03 Bio-Rad Laboratories, Inc. Reagent combination for solid phase immunofluorescent assay
US4340564A (en) 1980-07-21 1982-07-20 Daryl Laboratories, Inc. Immunoadsorptive surface coating for solid-phase immunosubstrate and solid-phase immunosubstrate
US4673288A (en) 1981-05-15 1987-06-16 Ratcom, Inc. Flow cytometry
US4499052A (en) * 1982-08-30 1985-02-12 Becton, Dickinson And Company Apparatus for distinguishing multiple subpopulations of cells
JPS59174742A (ja) 1983-03-25 1984-10-03 Agency Of Ind Science & Technol 微小粒子を区分又は選別する方法及びその装置
US4713348A (en) 1983-04-05 1987-12-15 Syntex (U.S.A.) Inc. Fluorescent multiparameter particle analysis
DE3322373C2 (de) 1983-05-19 1986-12-04 Ioannis Dr. 3000 Hannover Tripatzis Testmittel und Verfahren zum Nachweis von Antigenen und/oder Antikörpern
US4710021A (en) 1983-10-14 1987-12-01 Sequoia-Turner Corporation Particulate matter analyzing apparatus and method
US4665020A (en) 1984-05-30 1987-05-12 United States Department Of Energy Flow cytometer measurement of binding assays
US4661913A (en) 1984-09-11 1987-04-28 Becton, Dickinson And Company Apparatus and method for the detection and classification of articles using flow cytometry techniques
US4676640A (en) 1984-09-12 1987-06-30 Syntex (U.S.A.) Inc. Fluctuation analysis for enhanced particle detection
US5093234A (en) 1984-12-24 1992-03-03 Caribbean Microparticles Corporation Method of aligning, compensating, and calibrating a flow cytometer for analysis of samples, and microbead standards kit therefor
US4918004A (en) 1984-12-24 1990-04-17 Caribbean Microparticles Corporation Method of calibrating a flow cytometer or fluorescence microscope for quantitating binding antibodies on a selected sample, and microbead calibration kit therefor
US5380663A (en) * 1984-12-24 1995-01-10 Caribbean Microparticles Corporation Automated system for performance analysis and fluorescence quantitation of samples
US4857451A (en) 1984-12-24 1989-08-15 Flow Cytometry Standards Corporation Method of compensating and calibrating a flow cytometer, and microbead standards kit therefor
US4884886A (en) 1985-02-08 1989-12-05 The United States Of America As Represented By The Department Of Energy Biological particle identification apparatus
EP0200132A3 (de) 1985-04-23 1987-08-26 Hoechst-Roussel Pharmaceuticals Incorporated (Aminoalkylthio)-hydroxydibenzoxepine, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
EP0200113A3 (de) * 1985-04-30 1987-03-18 Pandex Laboratories, Inc. Verfahren der Nukleinsäuren-Hybridisierungsprobe unter Zusatz eines lumineszierenden Labels
US4868104A (en) 1985-09-06 1989-09-19 Syntex (U.S.A.) Inc. Homogeneous assay for specific polynucleotides
US5281517A (en) * 1985-11-04 1994-01-25 Cell Analysis Systems, Inc. Methods for immunoploidy analysis
US4767205A (en) 1986-01-28 1988-08-30 Flow Cytometry Standards Corporation Composition and method for hidden identification
CA1301606C (en) * 1986-05-02 1992-05-26 David H. Gillespie Chaotropic method for evaluating nucleic acids in a biological sample
US5319079A (en) 1986-05-15 1994-06-07 Beckman Instruments, Inc. Process for terminal substituting of a polynucleotide
SE458968B (sv) * 1987-06-16 1989-05-22 Wallac Oy Biospecifikt analysfoerfarande foer flera analyter i vilket ingaar partikelraekning och maerkning med fluorescerande maerksubstanser
US4987539A (en) * 1987-08-05 1991-01-22 Stanford University Apparatus and method for multidimensional characterization of objects in real time
US5403711A (en) 1987-11-30 1995-04-04 University Of Iowa Research Foundation Nucleic acid hybridization and amplification method for detection of specific sequences in which a complementary labeled nucleic acid probe is cleaved
US4887721A (en) 1987-11-30 1989-12-19 The United States Of America As Represented By The United States Department Of Energy Laser particle sorter
US5104791A (en) * 1988-02-09 1992-04-14 E. I. Du Pont De Nemours And Company Particle counting nucleic acid hybridization assays
US5385822A (en) 1988-05-02 1995-01-31 Zynaxis, Inc. Methods for detection and quantification of cell subsets within subpopulations of a mixed cell population
NO164622C (no) * 1988-05-11 1990-10-24 Tore Lindmo Binaer immunometrisk partikkelbasert metode for maaling av spesifikke serum-antigener ved hjelp av vaeskestroemsmikrofotometri og et ferdigpreparert maaloppsett derav.
US4905169A (en) 1988-06-02 1990-02-27 The United States Of America As Represented By The United States Department Of Energy Method and apparatus for simultaneously measuring a plurality of spectral wavelengths present in electromagnetic radiation
US5149661A (en) 1988-06-08 1992-09-22 Sarasep, Inc. Fluid analysis with particulate reagent suspension
US5408307A (en) 1988-07-11 1995-04-18 Omron Tateisi Electronics Co. Cell analyzer
FR2638848B1 (fr) 1988-11-04 1993-01-22 Chemunex Sa Procede de detection et/ou de dosage dans un milieu liquide ou semi-liquide d'au moins une substance organique, biologique ou medicamenteuse soluble, par une methode d'agglutination
GB8902689D0 (en) * 1989-02-07 1989-03-30 Ici Plc Assay method
US5156810A (en) 1989-06-15 1992-10-20 Biocircuits Corporation Biosensors employing electrical, optical and mechanical signals
CA1341094C (en) 1989-09-25 2000-09-05 Ronald G. Worton Diagnosis for malignant hyperthermia
US5107422A (en) 1989-10-02 1992-04-21 Kamentsky Louis A Method and apparatus for measuring multiple optical properties of biological specimens
US5401847A (en) 1990-03-14 1995-03-28 Regents Of The University Of California DNA complexes with dyes designed for energy transfer as fluorescent markers
US5150313A (en) 1990-04-12 1992-09-22 Regents Of The University Of California Parallel pulse processing and data acquisition for high speed, low error flow cytometry
US5326692B1 (en) 1992-05-13 1996-04-30 Molecular Probes Inc Fluorescent microparticles with controllable enhanced stokes shift
US5224058A (en) 1990-05-01 1993-06-29 Becton, Dickinson And Company Method for data transformation
US5273881A (en) 1990-05-07 1993-12-28 Daikin Industries, Ltd. Diagnostic applications of double D-loop formation
US5127730A (en) 1990-08-10 1992-07-07 Regents Of The University Of Minnesota Multi-color laser scanning confocal imaging system
US5204884A (en) 1991-03-18 1993-04-20 University Of Rochester System for high-speed measurement and sorting of particles
US5199576A (en) 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
AU1791192A (en) * 1991-04-05 1992-11-02 Pattern Recognition Direct data base analysis, forecasting and diagnosis method
US5286452A (en) 1991-05-20 1994-02-15 Sienna Biotech, Inc. Simultaneous multiple assays
ATE171543T1 (de) * 1991-07-16 1998-10-15 Transmed Biotech Inc Verfahren und zusammensetzungen für die gleichzeitige analyse einer vielzahl von analyten
US5290707A (en) * 1991-11-25 1994-03-01 The United States Of America As Represented By The Secretary Of The Army Method for detection of microorganisms
AU5407994A (en) 1992-10-30 1994-05-24 Cetac Technologies Incorporated Method for particulate reagent sample treatment
US5429923A (en) 1992-12-11 1995-07-04 President And Fellows Of Harvard College Method for detecting hypertrophic cardiomyophathy associated mutations
US5367474A (en) 1993-02-08 1994-11-22 Coulter Corporation Flow cytometer
CA2125228A1 (en) * 1993-06-08 1994-12-09 Thomas J. Mercolino Three-color flow cytometry with automatic gating function
US5981180A (en) * 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods

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CA2227895A1 (en) 1997-04-17
WO1997014028A3 (en) 1997-09-25
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US6939720B2 (en) 2005-09-06
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EP0852004B1 (de) 2011-01-19
WO1997014028A2 (en) 1997-04-17

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