DE602006015908D1 - Mikrokugeln mit fluoreszente und magnetische eigenschaften - Google Patents

Mikrokugeln mit fluoreszente und magnetische eigenschaften

Info

Publication number
DE602006015908D1
DE602006015908D1 DE602006015908T DE602006015908T DE602006015908D1 DE 602006015908 D1 DE602006015908 D1 DE 602006015908D1 DE 602006015908 T DE602006015908 T DE 602006015908T DE 602006015908 T DE602006015908 T DE 602006015908T DE 602006015908 D1 DE602006015908 D1 DE 602006015908D1
Authority
DE
Germany
Prior art keywords
microspheres
fluorescent
microsphere
subsets
microballs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602006015908T
Other languages
English (en)
Inventor
Don J Chandler
Jason Bedre
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Luminex Corp
Original Assignee
Luminex Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Luminex Corp filed Critical Luminex Corp
Publication of DE602006015908D1 publication Critical patent/DE602006015908D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G01N33/54326—Magnetic particles
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y25/00—Nanomagnetism, e.g. magnetoimpedance, anisotropic magnetoresistance, giant magnetoresistance or tunneling magnetoresistance
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/02—Use of particular materials as binders, particle coatings or suspension media therefor
    • C09K11/025—Use of particular materials as binders, particle coatings or suspension media therefor non-luminescent particle coatings or suspension media
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6486—Measuring fluorescence of biological material, e.g. DNA, RNA, cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0036—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties showing low dimensional magnetism, i.e. spin rearrangements due to a restriction of dimensions, e.g. showing giant magnetoresistivity
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/0302—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity characterised by unspecified or heterogeneous hardness or specially adapted for magnetic hardness transitions
    • H01F1/0311—Compounds
    • H01F1/0313—Oxidic compounds
    • H01F1/0315—Ferrites
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/04—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys
    • H01F1/06—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/04—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys
    • H01F1/06—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder
    • H01F1/063—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials metals or alloys in the form of particles, e.g. powder with a non magnetic core
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/032—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials
    • H01F1/10—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure
    • H01F1/11—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure in the form of particles
    • H01F1/111—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of hard-magnetic materials non-metallic substances, e.g. ferrites, e.g. [(Ba,Sr)O(Fe2O3)6] ferrites with hexagonal structure in the form of particles with a non-magnetic core
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/0018—Diamagnetic or paramagnetic materials, i.e. materials with low susceptibility and no hysteresis
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/01—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials
    • H01F1/03—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity
    • H01F1/12—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials
    • H01F1/34—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites
    • H01F1/36—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of inorganic materials characterised by their coercivity of soft-magnetic materials non-metallic substances, e.g. ferrites in the form of particles
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2995—Silane, siloxane or silicone coating
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2996—Glass particles or spheres
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/32—Composite [nonstructural laminate] of inorganic material having metal-compound-containing layer and having defined magnetic layer

Landscapes

  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Power Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Nanotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Food Science & Technology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Optics & Photonics (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Luminescent Compositions (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)
DE602006015908T 2005-01-20 2006-01-19 Mikrokugeln mit fluoreszente und magnetische eigenschaften Active DE602006015908D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US64554905P 2005-01-20 2005-01-20
PCT/US2006/002257 WO2006079016A1 (en) 2005-01-20 2006-01-19 Magnetic microspheres for use in fluorescence-based applications

Publications (1)

Publication Number Publication Date
DE602006015908D1 true DE602006015908D1 (de) 2010-09-16

Family

ID=36540172

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602006015908T Active DE602006015908D1 (de) 2005-01-20 2006-01-19 Mikrokugeln mit fluoreszente und magnetische eigenschaften

Country Status (12)

Country Link
US (6) US7718262B2 (de)
EP (2) EP2244270B1 (de)
JP (1) JP5042859B2 (de)
KR (1) KR101253265B1 (de)
CN (2) CN100541677C (de)
AT (1) ATE476744T1 (de)
CA (1) CA2595292C (de)
DE (1) DE602006015908D1 (de)
DK (1) DK2244270T3 (de)
ES (1) ES2391529T3 (de)
HK (2) HK1116913A1 (de)
WO (1) WO2006079016A1 (de)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2244270B1 (de) * 2005-01-20 2012-06-06 Luminex Corporation Magnetische Microkugeln und Fluoreszenz-basierte Anwendungen
US8296088B2 (en) 2006-06-02 2012-10-23 Luminex Corporation Systems and methods for performing measurements of one or more materials
JP2009540270A (ja) 2006-06-02 2009-11-19 ルミネックス・コーポレーション 磁性粒子を使用することと磁界を印加することを含む、１つ又は複数の材料の測定を実施するシステム及び方法
JP5401724B2 (ja) * 2007-12-03 2014-01-29 多摩川精機株式会社 被覆磁性微粒子を用いたバイオセンシング方法及び該方法に用いるバイオセンシング装置
CN101939649B (zh) * 2008-01-07 2013-10-23 卢米耐克斯公司 从复杂样品基质中对细胞进行分离和计数
EP2240775B1 (de) * 2008-01-07 2011-09-28 Luminex Corporation Immunomagnetische erfassung und abbildung biologischer zielmoleküle
JP2011516833A (ja) 2008-03-21 2011-05-26 アボット・ポイント・オブ・ケア 蛍光消光及び／又は蛍光退色を用いて個々の細胞又は粒状物質を分析するための方法及び装置
WO2009117652A1 (en) 2008-03-21 2009-09-24 Abbott Point Of Care, Inc. Method and apparatus for determining the hematocrit of a blood sample utilizing the intrinsic pigmentation of hemoglobin contained within the red blood cells
ES2398488T3 (es) 2008-03-21 2013-03-19 Abbott Point Of Care, Inc. Método y aparato para determinar los índices de células sanguíneas rojas en una muestra de sangre utilizando la pigmentación intrínseca de la hemoglobina contenida en células sanguíneas rojas
CA2719004C (en) 2008-03-21 2013-06-18 Abbott Point Of Care, Inc. Method and apparatus for determining a focal position of an imaging device adapted to image a biologic sample
WO2009117682A1 (en) * 2008-03-21 2009-09-24 Abbott Point Of Care, Inc. Method and apparatus for detecting and counting platelets individually and in aggregate clumps
JP5539958B2 (ja) 2008-04-02 2014-07-02 アボット ポイント オブ ケア インコーポレイテッド 薄膜状体液試料において実施される血清学的凝集イムノアッセイ及び他のイムノアッセイのための方法
ES2597927T3 (es) * 2008-04-09 2017-01-24 Abbott Point Of Care, Inc. Procedimiento para medir el área de una muestra dispuesta dentro de una cámara de análisis
JP5301894B2 (ja) * 2008-06-27 2013-09-25 富士フイルム株式会社 検出方法
WO2010029739A1 (ja) * 2008-09-11 2010-03-18 国立大学法人東京工業大学 蛍光分子を含有するポリマー粒子およびその製造方法
US20100255605A1 (en) * 2009-04-02 2010-10-07 Abbott Point Of Care, Inc. Method and device for transferring biologic fluid samples
JP5620154B2 (ja) * 2009-10-15 2014-11-05 公益財団法人神奈川科学技術アカデミー 中空微小体およびその作製方法
JP5678565B2 (ja) * 2009-12-08 2015-03-04 Jnc株式会社 磁性微粒子およびその製造方法
ES2438841T3 (es) * 2009-12-31 2014-01-20 Abbott Point Of Care, Inc. Método y aparato para determinar el volumen celular medio de los glóbulos rojos en la sangre
US9500644B2 (en) 2010-02-23 2016-11-22 Luminex Corporation Particle populations and assays having varying amounts of magnetic material and particle concentrations among different subsets of particles and methods for processing assays having such particle populations
EP3072968A1 (de) 2010-02-25 2016-09-28 Advanced Liquid Logic, Inc. Verfahren zur herstellung von nukleinsäure-bibliotheken
WO2011116305A1 (en) 2010-03-18 2011-09-22 Abbott Point Of Care, Inc. Method and apparatus for optically determining at least one hemoglobin related parameter of a whole blood sample
US20130105709A1 (en) * 2010-06-04 2013-05-02 Michael Himmelhaus Optical Cavity Mode Excitations in Magnetic Fluorescent Microparticles
WO2012068055A2 (en) 2010-11-17 2012-05-24 Advanced Liquid Logic, Inc. Capacitance detection in a droplet actuator
EP2705374A4 (de) 2011-05-02 2014-11-12 Advanced Liquid Logic Inc Molekulare diagnoseplattform
CA2833897C (en) 2011-05-09 2020-05-19 Advanced Liquid Logic, Inc. Microfluidic feedback using impedance detection
AU2012253595B2 (en) 2011-05-10 2016-10-20 Advanced Liquid Logic, Inc. Enzyme concentration and assays
CN102343240B (zh) * 2011-06-27 2013-07-10 苏州科技学院 荧光磁性双功能树状分子微球及其制备方法
WO2013078216A1 (en) 2011-11-21 2013-05-30 Advanced Liquid Logic Inc Glucose-6-phosphate dehydrogenase assays
US9803237B2 (en) 2012-04-24 2017-10-31 California Institute Of Technology Slip-induced compartmentalization
US20140072959A1 (en) 2012-09-12 2014-03-13 Force Diagnostics, Inc. Rapid tests for insurance underwriting
US20140243231A1 (en) 2013-02-28 2014-08-28 The Terasaki Family Foundation Methods and compositions for the efficient reuse of multiply dyed particles
EP2973404B1 (de) 2013-03-15 2019-02-27 Luminex Corporation Echtzeitverfolgung und korrelation von mikrokugeln
WO2014150816A1 (en) 2013-03-15 2014-09-25 Ameriforge Group Inc. Drilling riser assemblies
US9753042B2 (en) * 2013-04-23 2017-09-05 Rosalind Franklin University Of Medicine And Science Kits for determining male fertility by measuring levels of a2V-ATPase, G-CSF, MIP 1 alpha, MCP-1, and methods and kits for improving reproductive outcomes in artificial insemination procedures
WO2015010379A1 (zh) 2013-07-26 2015-01-29 清华大学 基于闭合超导线圈组的磁场屏蔽系统及磁场屏蔽设备
WO2015023747A1 (en) 2013-08-13 2015-02-19 Advanced Liquid Logic, Inc. Methods of improving accuracy and precision of droplet metering using an on-actuator reservoir as the fluid input
CA2920390A1 (en) 2013-08-30 2015-03-05 Illumina, Inc. Manipulation of droplets on hydrophilic or variegated-hydrophilic surfaces
CN103752821B (zh) * 2014-01-24 2016-01-20 云南大学 一种制备金属微粉覆盖表面的导电复合微球材料方法
AU2015249592A1 (en) 2014-04-24 2016-12-15 Immusant, Inc. Use of Interleukin-2 for diagnosis of Celiac disease
SG11201609053YA (en) 2014-04-29 2016-11-29 Illumina Inc Multiplexed single cell gene expression analysis using template switch and tagmentation
CN104356323B (zh) * 2014-10-13 2017-05-17 北京大学 一种磁性分子印迹纳米颗粒及其制备方法和应用
US10319502B2 (en) 2014-10-23 2019-06-11 Corning Incorporated Polymer-encapsulated magnetic nanoparticles
EP3221344A2 (de) 2014-11-21 2017-09-27 Immusant Inc. Peptide zur behandlung und diagnose von typ-1-diabetes
CN104559674A (zh) * 2015-01-20 2015-04-29 芜湖县双宝建材有限公司 一种高韧性高去污性能涂料
EP3271073B1 (de) 2015-03-20 2019-06-12 Illumina, Inc. Fluidikkassette zur verwendung in vertikaler oder weitgehend vertikaler position
EP4086357A1 (de) 2015-08-28 2022-11-09 Illumina, Inc. Nukleinsäuresequenzanalyse aus einzelnen zellen
CA3016221C (en) 2016-04-07 2021-09-28 Illumina, Inc. Methods and systems for construction of normalized nucleic acid libraries
US10317413B2 (en) 2016-11-14 2019-06-11 The Board Of Regents Of The University Of Texas System Method and kit for detection of anti-zika virus antibodies
EP3579974A4 (de) * 2017-02-08 2020-12-30 Becton, Dickinson and Company Vorrichtungen für getrocknete farbstoffreagenzien und verfahren zur herstellung und verwendung davon
AU2019212953B2 (en) 2018-01-29 2023-02-02 St. Jude Children's Research Hospital, Inc. Method for nucleic acid amplification
CN110732296B (zh) * 2018-07-18 2021-09-03 苏州为度生物技术有限公司 具有蓬松壳层的磁性微球的制备方法
CN109158063A (zh) * 2018-07-31 2019-01-08 湖南华腾制药有限公司 一种磁性高分子微球结构及其制备
CN109092219A (zh) * 2018-07-31 2018-12-28 湖南华腾制药有限公司 一种磁性高分子微球结构及其制备
CN109331753A (zh) * 2018-10-18 2019-02-15 中翰盛泰生物技术股份有限公司 一种羧基磁性微球、制备方法及应用
AU2021249046A1 (en) 2020-03-30 2022-10-20 Illumina, Inc. Methods and compositions for preparing nucleic acid libraries
CN111393574B (zh) * 2020-03-31 2022-02-22 中国科学院过程工程研究所 一种表面带有功能基团的磁性微球及其制备方法和用途
DE102020132495B3 (de) 2020-12-07 2022-05-12 Bundesrepublik Deutschland, Wirtschaft und Energie, Bundesanstalt für Materialforschung und -prüfung (BAM) Partikel, die aus einem organischen Polymerkern, einer ersten anorganischen Oxidschale, die ein magnetisches Material enthält, und einer mesoporösen zweiten anorganischen Schale bestehen
CN112745833B (zh) * 2020-12-18 2024-01-05 华侨大学 一种时间分辨荧光磁性纳米微球的制备方法
CN115127974A (zh) * 2021-03-24 2022-09-30 深圳市帝迈生物技术有限公司 磁珠及其制作方法
CN114152742B (zh) * 2021-11-30 2024-05-28 深圳市易瑞生物技术股份有限公司 包含磁性发光微球的光激化学发光免疫检测的试剂盒及其应用

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2017125B (en) * 1978-03-17 1982-07-21 California Inst Of Techn Polyglutaraldehyde synthesis and protein bonding substrates
US5200270A (en) * 1986-02-25 1993-04-06 Toyo Soda Manufacturing Co., Ltd. Carrier for a biologically active component for immunoassay or enzymatic reaction
US5091206A (en) 1987-10-26 1992-02-25 Baxter Diagnostics Inc. Process for producing magnetically responsive polymer particles and application thereof
US6013531A (en) 1987-10-26 2000-01-11 Dade International Inc. Method to use fluorescent magnetic polymer particles as markers in an immunoassay
US5032381A (en) 1988-12-20 1991-07-16 Tropix, Inc. Chemiluminescence-based static and flow cytometry
US5091200A (en) 1989-01-10 1992-02-25 International Flavors & Fragrances Inc. Process for microwave browning uncooked baked goods foodstuffs
WO1991009141A1 (en) 1989-12-14 1991-06-27 Baxter Diagnostics Inc. Magnetically responsive fluorescent polymer particles and application thereof
EP0543988B1 (de) * 1991-06-17 1995-06-21 Dade International Inc. Verfahren zur Herstellung magnetisch empfindlicherPolymerpartikel und ihre Anwendung
US5648124A (en) 1993-07-09 1997-07-15 Seradyn, Inc. Process for preparing magnetically responsive microparticles
US5981180A (en) 1995-10-11 1999-11-09 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and methods
ATE496288T1 (de) 1995-10-11 2011-02-15 Luminex Corp Gleichzeitige mehrfachanalyse klinischer proben
US5736330A (en) 1995-10-11 1998-04-07 Luminex Corporation Method and compositions for flow cytometric determination of DNA sequences
GB9524393D0 (en) * 1995-11-29 1996-01-31 Mini Agriculture & Fisheries Extraction and labelling of materials
US6449562B1 (en) 1996-10-10 2002-09-10 Luminex Corporation Multiplexed analysis of clinical specimens apparatus and method
US5948627A (en) 1997-05-30 1999-09-07 One Lambda Immunobead flow cytometric detection of anti-HLA panel-reactive antibody
AU8148898A (en) 1997-06-23 1999-01-04 Luminex Corporation Interlaced lasers for multiple fluorescence measurement
WO1999019515A1 (en) 1997-10-14 1999-04-22 Luminex Corporation Precision fluorescently dyed particles and methods of making and using same
JP3468750B2 (ja) 1998-01-22 2003-11-17 ルミネックス コーポレイション 多数の蛍光シグナルを有する微小粒子
WO1999058955A1 (en) * 1998-05-14 1999-11-18 Luminex Corporation Multi-analyte diagnostic system and computer implemented process for same
AU3996299A (en) 1998-05-14 1999-11-29 Luminex Corporation Diode laser based measurement apparatus
CA2328408C (en) 1998-05-14 2005-02-15 Luminex Corporation Zero dead time architecture and method for flow cytometer
AU4324900A (en) * 1999-02-05 2000-08-25 University Of Maryland At Baltimore Luminescence spectral properties of cds nanoparticles
US7179660B1 (en) * 2000-03-06 2007-02-20 Dade Behring Marburg Gmbh Carriers coated with polysaccharides, their preparation and use
US6548264B1 (en) * 2000-05-17 2003-04-15 University Of Florida Coated nanoparticles
US20030186465A1 (en) 2001-11-27 2003-10-02 Kraus Robert H. Apparatus used in identification, sorting and collection methods using magnetic microspheres and magnetic microsphere kits
KR20070095306A (ko) 2004-12-17 2007-09-28 루미넥스 코포레이션 시스템, 조명 서브 시스템 및 형광원에 의해 방출된 형광을증가하는 방법
EP2244270B1 (de) * 2005-01-20 2012-06-06 Luminex Corporation Magnetische Microkugeln und Fluoreszenz-basierte Anwendungen

Also Published As

Publication number Publication date
HK1141133A1 (en) 2010-10-29
CN101107680A (zh) 2008-01-16
CA2595292A1 (en) 2006-07-27
US20160266103A1 (en) 2016-09-15
ES2391529T3 (es) 2012-11-27
EP1842211B1 (de) 2010-08-04
US7718262B2 (en) 2010-05-18
KR101253265B1 (ko) 2013-04-10
US8283037B2 (en) 2012-10-09
US9645142B2 (en) 2017-05-09
US20140042366A1 (en) 2014-02-13
EP2244270A2 (de) 2010-10-27
JP5042859B2 (ja) 2012-10-03
WO2006079016A1 (en) 2006-07-27
EP2244270B1 (de) 2012-06-06
US20060159962A1 (en) 2006-07-20
US8568881B2 (en) 2013-10-29
DK2244270T3 (da) 2012-09-10
KR20070101339A (ko) 2007-10-16
HK1116913A1 (en) 2009-01-02
CN100541677C (zh) 2009-09-16
CN101650998B (zh) 2013-02-06
CA2595292C (en) 2014-03-04
JP2008528973A (ja) 2008-07-31
EP1842211A1 (de) 2007-10-10
CN101650998A (zh) 2010-02-17
EP2244270A3 (de) 2011-02-23
US8968874B2 (en) 2015-03-03
US20100178709A1 (en) 2010-07-15
US9376613B2 (en) 2016-06-28
US20150152325A1 (en) 2015-06-04
ATE476744T1 (de) 2010-08-15
US20130095573A1 (en) 2013-04-18

Similar Documents

Publication Publication Date Title
DE602006015908D1 (de) Mikrokugeln mit fluoreszente und magnetische eigenschaften
DE60221006D1 (de) Reibungsmaterial mit Nanopartikel enthaltender Reibungsveräanderungsschicht
DE602005009343D1 (de) Thermoplastische Matrix enthaltend silanisierte pyrogene Kieselsäure
GB0900179D0 (en) Electroluminescent materials
DK1836239T3 (da) Kompositmaterialer, der indeholder carbonnanopartikler
DE50214010D1 (de) Indanverbindungen mit negativer dielektrischer anisotropie
EP1709699B8 (de) Konjugierte polymere, deren darstellung und verwendung
ATE404155T1 (de) Prepreg, verbundmaterial und ihre anwendungen
DE60231511D1 (de) Strukturen mit anorganischen polymerteilchenmischungen
DE602005006850D1 (de) Cholestere monoschichten und monoschichtpigmente mit besonderen eigenschaften, deren herstellung und verwendung
TW200643091A (en) Polymer nanocomposite having surface modified nanoparticles and methods of preparing same
ATE513890T1 (de) Kern-hülle-nanopartikel und herstellungsverfahren dafür
ATE302825T1 (de) Pulverlacke mit niedrigem glanz
BRPI0606575A2 (pt) mistura aquecida, sistema de pigmentos de alto desempenho, e papel decorativo
ATE519727T1 (de) 4-chlor-4-alkoxy-1,1,1-trifluor-2-butanone, deren herstellung und deren verwendung bei der herstellung von 4-alkoxy-1,1,1-trifluor-3-buten-2-onen
EP1160246B8 (de) Funktionalisierte Thiophenoligomere und ihre Verwendung als Fluoreszenzmarker
EP1707655A4 (de) Carbonfasergebilde
JP2007324210A5 (de)
ATE452166T1 (de) Beschichtungsstoffe und ihre verwendung zur herstellung schweissbarer beschichtungen
DE602004022979D1 (de) Verbundstoff aus hochschmelzendem polymer und nanoton mit verbesserten eigenschaften
TW200621887A (en) Light-diffusing polycarbonate resin composition
DE50206607D1 (de) Poröses Tintenstrahlaufzeichnungsmaterial
ATE303864T1 (de) Herstellung von polymerteilchen
TW200613445A (en) Light-diffusive resin composition
ZA200806372B (en) Novel monomeric and polymeric materials