JP4233524B2 - 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 - Google Patents
8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 Download PDFInfo
- Publication number
- JP4233524B2 JP4233524B2 JP2004530186A JP2004530186A JP4233524B2 JP 4233524 B2 JP4233524 B2 JP 4233524B2 JP 2004530186 A JP2004530186 A JP 2004530186A JP 2004530186 A JP2004530186 A JP 2004530186A JP 4233524 B2 JP4233524 B2 JP 4233524B2
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- xanthine
- piperidin
- esi
- mass spectrum
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000002360 preparation method Methods 0.000 title claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 title claims description 3
- WNHHLYZOSOUUQW-UHFFFAOYSA-N 8-(3-aminopiperidin-1-yl)-3,7-dihydropurine-2,6-dione Chemical compound C1C(N)CCCN1C(N1)=NC2=C1C(=O)NC(=O)N2 WNHHLYZOSOUUQW-UHFFFAOYSA-N 0.000 title 1
- -1 4-methoxy-1-naphthylmethyl group Chemical group 0.000 claims description 591
- 150000001875 compounds Chemical class 0.000 claims description 132
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 80
- 239000000203 mixture Substances 0.000 claims description 71
- 229940075420 xanthine Drugs 0.000 claims description 67
- 150000003839 salts Chemical class 0.000 claims description 57
- 238000006243 chemical reaction Methods 0.000 claims description 28
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims description 27
- 238000000034 method Methods 0.000 claims description 19
- 238000011282 treatment Methods 0.000 claims description 17
- ILTRPILDWNCOMQ-QGZVFWFLSA-N 8-[(3r)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-(quinazolin-2-ylmethyl)purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=CN=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](N)C1 ILTRPILDWNCOMQ-QGZVFWFLSA-N 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 9
- 230000008569 process Effects 0.000 claims description 9
- 125000006239 protecting group Chemical group 0.000 claims description 9
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical compound O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 claims description 5
- 208000008589 Obesity Diseases 0.000 claims description 4
- 239000000969 carrier Substances 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 150000007522 mineralic acids Chemical class 0.000 claims description 4
- 235000020824 obesity Nutrition 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 4
- DFWUAFCLJJBUNR-LJQANCHMSA-N 8-[(3r)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](N)C1 DFWUAFCLJJBUNR-LJQANCHMSA-N 0.000 claims description 3
- DFWUAFCLJJBUNR-IBGZPJMESA-N 8-[(3s)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@H](N)C1 DFWUAFCLJJBUNR-IBGZPJMESA-N 0.000 claims description 3
- PEUGKEHLRUVPAN-UHFFFAOYSA-N piperidin-3-amine Chemical compound NC1CCCNC1 PEUGKEHLRUVPAN-UHFFFAOYSA-N 0.000 claims description 3
- VLFSSWGBDCUQHN-ONEGZZNKSA-N 8-(3-aminopiperidin-1-yl)-7-[(e)-but-2-enyl]-1-(isoquinolin-1-ylmethyl)-3-methylpurine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=CN=3)C(=O)C=2N(C/C=C/C)C=1N1CCCC(N)C1 VLFSSWGBDCUQHN-ONEGZZNKSA-N 0.000 claims description 2
- UPFJNOBWVRMCRL-UHFFFAOYSA-N 8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-1-(isoquinolin-1-ylmethyl)-3-methylpurine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=CN=3)C(=O)C=2N(CC#CC)C=1N1CCCC(N)C1 UPFJNOBWVRMCRL-UHFFFAOYSA-N 0.000 claims description 2
- HZLSPAMVOSFVEA-UHFFFAOYSA-N 8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-1-[(4-methoxynaphthalen-1-yl)methyl]-3-methylpurine-2,6-dione Chemical compound C12=CC=CC=C2C(OC)=CC=C1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCCC(N)C1 HZLSPAMVOSFVEA-UHFFFAOYSA-N 0.000 claims description 2
- ILTRPILDWNCOMQ-UHFFFAOYSA-N 8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(quinazolin-2-ylmethyl)purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=CN=3)C(=O)C=2N(CC#CC)C=1N1CCCC(N)C1 ILTRPILDWNCOMQ-UHFFFAOYSA-N 0.000 claims description 2
- IVWUOVGPOSTUDO-UHFFFAOYSA-N 8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(quinolin-4-ylmethyl)purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4N=CC=3)C(=O)C=2N(CC#CC)C=1N1CCCC(N)C1 IVWUOVGPOSTUDO-UHFFFAOYSA-N 0.000 claims description 2
- QXEHNRZVDHJFSB-UHFFFAOYSA-N 8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(quinolin-6-ylmethyl)purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C=C4C=CC=NC4=CC=3)C(=O)C=2N(CC#CC)C=1N1CCCC(N)C1 QXEHNRZVDHJFSB-UHFFFAOYSA-N 0.000 claims description 2
- DFWUAFCLJJBUNR-UHFFFAOYSA-N 8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCCC(N)C1 DFWUAFCLJJBUNR-UHFFFAOYSA-N 0.000 claims description 2
- MXOCXLWHNGNQEB-UHFFFAOYSA-N 8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-[(4-methylisoquinolin-1-yl)methyl]purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(C)=CN=3)C(=O)C=2N(CC#CC)C=1N1CCCC(N)C1 MXOCXLWHNGNQEB-UHFFFAOYSA-N 0.000 claims description 2
- PMEPJDSKCVFSDO-REMYHPOOSA-N 8-[(3r)-3-aminopiperidin-1-yl]-7-[(e)-but-2-enyl]-3-methyl-1-(quinazolin-2-ylmethyl)purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=CN=3)C(=O)C=2N(C/C=C/C)C=1N1CCC[C@@H](N)C1 PMEPJDSKCVFSDO-REMYHPOOSA-N 0.000 claims description 2
- UCTWCIQYPZZXKW-VZSQWMKGSA-N 8-[(3r)-3-aminopiperidin-1-yl]-7-[(e)-but-2-enyl]-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=C(C)N=3)C(=O)C=2N(C/C=C/C)C=1N1CCC[C@@H](N)C1 UCTWCIQYPZZXKW-VZSQWMKGSA-N 0.000 claims description 2
- HZLSPAMVOSFVEA-LJQANCHMSA-N 8-[(3r)-3-aminopiperidin-1-yl]-7-but-2-ynyl-1-[(4-methoxynaphthalen-1-yl)methyl]-3-methylpurine-2,6-dione Chemical compound C12=CC=CC=C2C(OC)=CC=C1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCC[C@@H](N)C1 HZLSPAMVOSFVEA-LJQANCHMSA-N 0.000 claims description 2
- MXOCXLWHNGNQEB-GOSISDBHSA-N 8-[(3r)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[(4-methylisoquinolin-1-yl)methyl]purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(C)=CN=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](N)C1 MXOCXLWHNGNQEB-GOSISDBHSA-N 0.000 claims description 2
- PMEPJDSKCVFSDO-IDOMTICXSA-N 8-[(3s)-3-aminopiperidin-1-yl]-7-[(e)-but-2-enyl]-3-methyl-1-(quinazolin-2-ylmethyl)purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=CN=3)C(=O)C=2N(C/C=C/C)C=1N1CCC[C@H](N)C1 PMEPJDSKCVFSDO-IDOMTICXSA-N 0.000 claims description 2
- UCTWCIQYPZZXKW-PXPVJAHISA-N 8-[(3s)-3-aminopiperidin-1-yl]-7-[(e)-but-2-enyl]-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=C(C)N=3)C(=O)C=2N(C/C=C/C)C=1N1CCC[C@H](N)C1 UCTWCIQYPZZXKW-PXPVJAHISA-N 0.000 claims description 2
- HZLSPAMVOSFVEA-IBGZPJMESA-N 8-[(3s)-3-aminopiperidin-1-yl]-7-but-2-ynyl-1-[(4-methoxynaphthalen-1-yl)methyl]-3-methylpurine-2,6-dione Chemical compound C12=CC=CC=C2C(OC)=CC=C1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCC[C@H](N)C1 HZLSPAMVOSFVEA-IBGZPJMESA-N 0.000 claims description 2
- ILTRPILDWNCOMQ-KRWDZBQOSA-N 8-[(3s)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-(quinazolin-2-ylmethyl)purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=CN=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@H](N)C1 ILTRPILDWNCOMQ-KRWDZBQOSA-N 0.000 claims description 2
- MXOCXLWHNGNQEB-SFHVURJKSA-N 8-[(3s)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[(4-methylisoquinolin-1-yl)methyl]purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(C)=CN=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@H](N)C1 MXOCXLWHNGNQEB-SFHVURJKSA-N 0.000 claims description 2
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- 208000001132 Osteoporosis Diseases 0.000 claims description 2
- 206010003246 arthritis Diseases 0.000 claims description 2
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical compound N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims description 2
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- 238000002054 transplantation Methods 0.000 claims description 2
- 239000008196 pharmacological composition Substances 0.000 claims 8
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- PEUGKEHLRUVPAN-RXMQYKEDSA-N (3r)-piperidin-3-amine Chemical compound N[C@@H]1CCCNC1 PEUGKEHLRUVPAN-RXMQYKEDSA-N 0.000 claims 1
- NNJKEVOXNDMLBL-SHCNBLLESA-N 8-[(3r)-3-aminopiperidin-1-yl]-7-[(e)-but-2-enyl]-3-methyl-1-[(4-methylisoquinolin-1-yl)methyl]purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(C)=CN=3)C(=O)C=2N(C/C=C/C)C=1N1CCC[C@@H](N)C1 NNJKEVOXNDMLBL-SHCNBLLESA-N 0.000 claims 1
- NNJKEVOXNDMLBL-WRFKIARRSA-N 8-[(3s)-3-aminopiperidin-1-yl]-7-[(e)-but-2-enyl]-3-methyl-1-[(4-methylisoquinolin-1-yl)methyl]purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(C)=CN=3)C(=O)C=2N(C/C=C/C)C=1N1CCC[C@H](N)C1 NNJKEVOXNDMLBL-WRFKIARRSA-N 0.000 claims 1
- LTXREWYXXSTFRX-KRWDZBQOSA-N 8-[(3s)-3-aminopiperidin-1-yl]-7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]purine-2,6-dione Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@H](N)C1 LTXREWYXXSTFRX-KRWDZBQOSA-N 0.000 claims 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 1014
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 778
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 748
- 238000001819 mass spectrum Methods 0.000 description 624
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 443
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- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 169
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- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 10
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- SHRMUBVUMXDVPY-FHVRUZERSA-N tert-butyl n-[(3r)-1-[7-[(e)-but-2-enyl]-3-methyl-2,6-dioxo-1-[2-oxo-2-[2-(propanoylamino)phenyl]ethyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound CCC(=O)NC1=CC=CC=C1C(=O)CN1C(=O)C(N(C\C=C\C)C(N2C[C@@H](CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O SHRMUBVUMXDVPY-FHVRUZERSA-N 0.000 description 1
- UJKIEIPDMMUQFJ-ROUKRRSUSA-N tert-butyl n-[(3r)-1-[7-[(e)-but-2-enyl]-3-methyl-2,6-dioxo-1-phenacylpurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(C/C=C/C)C(N3C[C@@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1 UJKIEIPDMMUQFJ-ROUKRRSUSA-N 0.000 description 1
- QKNDSSUJHFJZTD-KTRBRXNASA-N tert-butyl n-[(3r)-1-[7-[(e)-but-2-enyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)NC(=O)C=2N(C/C=C/C)C=1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1 QKNDSSUJHFJZTD-KTRBRXNASA-N 0.000 description 1
- ZIPKVZVXXBBGKA-XMMPIXPASA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-1-[(4-cyanonaphthalen-1-yl)methyl]-3-cyclopropyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1N(CC=2C3=CC=CC=C3C(C#N)=CC=2)C(=O)C=2N(CC#CC)C(N3C[C@@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N1C1CC1 ZIPKVZVXXBBGKA-XMMPIXPASA-N 0.000 description 1
- FUXLBXYENAXCTK-HSZRJFAPSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-1-[(4-cyanonaphthalen-1-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(C#N)=CC=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1 FUXLBXYENAXCTK-HSZRJFAPSA-N 0.000 description 1
- AGXRZAGACCISEI-OAQYLSRUSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-1-[(4-fluoronaphthalen-1-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(F)=CC=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1 AGXRZAGACCISEI-OAQYLSRUSA-N 0.000 description 1
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- HTACRSYPEXPVPQ-LJQANCHMSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-1-[2-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC(=O)C=3C=4OCCOC=4C=CC=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1 HTACRSYPEXPVPQ-LJQANCHMSA-N 0.000 description 1
- DIHJABIPYKBHOZ-LJQANCHMSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-1-[2-(2-methoxyphenyl)-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound COC1=CC=CC=C1C(=O)CN1C(=O)C(N(CC#CC)C(N2C[C@@H](CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O DIHJABIPYKBHOZ-LJQANCHMSA-N 0.000 description 1
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- MQADSMBWBSAEEY-HXUWFJFHSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-1-[2-(3-methoxyphenyl)-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound COC1=CC=CC(C(=O)CN2C(C=3N(CC#CC)C(N4C[C@@H](CCC4)NC(=O)OC(C)(C)C)=NC=3N(C)C2=O)=O)=C1 MQADSMBWBSAEEY-HXUWFJFHSA-N 0.000 description 1
- BAXMUYCKKYDOTR-HXUWFJFHSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-1-[[3-(difluoromethyl)isoquinolin-1-yl]methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=C(N=3)C(F)F)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1 BAXMUYCKKYDOTR-HXUWFJFHSA-N 0.000 description 1
- VMHNVRHMRKDPEV-OAQYLSRUSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-1-[[4-(difluoromethoxy)naphthalen-1-yl]methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(OC(F)F)=CC=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1 VMHNVRHMRKDPEV-OAQYLSRUSA-N 0.000 description 1
- ATKKEHMAJJJHPQ-HSZRJFAPSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-cyclopropyl-1-[(3-methylisoquinolin-1-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1N(CC=2C3=CC=CC=C3C=C(C)N=2)C(=O)C=2N(CC#CC)C(N3C[C@@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N1C1CC1 ATKKEHMAJJJHPQ-HSZRJFAPSA-N 0.000 description 1
- WUXLYGGCAQLWFG-HXUWFJFHSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-1-(1,5-naphthyridin-4-ylmethyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=NC=CC=C4N=CC=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1 WUXLYGGCAQLWFG-HXUWFJFHSA-N 0.000 description 1
- AAMOFATWOXYVIJ-JOCHJYFZSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1 AAMOFATWOXYVIJ-JOCHJYFZSA-N 0.000 description 1
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- PQEIZFATTRGTNW-HXUWFJFHSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1 PQEIZFATTRGTNW-HXUWFJFHSA-N 0.000 description 1
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- NOZWKVXKRXFUKL-OAQYLSRUSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-1-[(8-methylquinoxalin-6-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C=C4N=CC=NC4=C(C)C=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1 NOZWKVXKRXFUKL-OAQYLSRUSA-N 0.000 description 1
- GTQRYYITVWWQSK-GOSISDBHSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-1-[2-(2-nitrophenyl)-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1[N+]([O-])=O GTQRYYITVWWQSK-GOSISDBHSA-N 0.000 description 1
- GADBCBBAZIBHAC-GOSISDBHSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-1-[2-(3-methyl-2-oxo-1,3-benzoxazol-4-yl)-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC(=O)C=3C=4N(C)C(=O)OC=4C=CC=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1 GADBCBBAZIBHAC-GOSISDBHSA-N 0.000 description 1
- NHLCQOFYKHZAHJ-OAQYLSRUSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-1-[2-[2-(2-methylpropanoylamino)phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1NC(=O)C(C)C NHLCQOFYKHZAHJ-OAQYLSRUSA-N 0.000 description 1
- DPWONWYJLCXXLE-JOCHJYFZSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-(2-oxo-4-phenylbutyl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)CCC1=CC=CC=C1 DPWONWYJLCXXLE-JOCHJYFZSA-N 0.000 description 1
- JFUAYBBHAABEII-HXUWFJFHSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-(quinazolin-2-ylmethyl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=CN=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1 JFUAYBBHAABEII-HXUWFJFHSA-N 0.000 description 1
- MOILAUCKDPSUKH-AREMUKBSSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-[(3-phenylisoquinolin-1-yl)methyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(C1=CC=CC=C1C=1)=NC=1C1=CC=CC=C1 MOILAUCKDPSUKH-AREMUKBSSA-N 0.000 description 1
- GEKDBUOOXAPXBX-XMMPIXPASA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-[(4-phenylquinazolin-2-yl)methyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(N=C1C=CC=CC1=1)=NC=1C1=CC=CC=C1 GEKDBUOOXAPXBX-XMMPIXPASA-N 0.000 description 1
- AQGHRIHFXRHMTA-RUZDIDTESA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-[(8-phenylquinoxalin-6-yl)methyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(C=C1N=CC=NC1=1)=CC=1C1=CC=CC=C1 AQGHRIHFXRHMTA-RUZDIDTESA-N 0.000 description 1
- YCVSIZAIDSXEPN-XMMPIXPASA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-[2-oxo-2-(2-phenylphenyl)ethyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1C1=CC=CC=C1 YCVSIZAIDSXEPN-XMMPIXPASA-N 0.000 description 1
- OGRZFRWRFXYSRD-AREMUKBSSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-[2-oxo-2-(3-phenylphenyl)ethyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C(C=1)=CC=CC=1C1=CC=CC=C1 OGRZFRWRFXYSRD-AREMUKBSSA-N 0.000 description 1
- LYCVDUZOWLPYBU-HXUWFJFHSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-[2-oxo-2-[2-(propanoylamino)phenyl]ethyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound CCC(=O)NC1=CC=CC=C1C(=O)CN1C(=O)C(N(CC#CC)C(N2C[C@@H](CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O LYCVDUZOWLPYBU-HXUWFJFHSA-N 0.000 description 1
- VWSDJYLVKPBTDH-LJQANCHMSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-[2-oxo-2-[3-(trifluoromethoxy)phenyl]ethyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC(OC(F)(F)F)=C1 VWSDJYLVKPBTDH-LJQANCHMSA-N 0.000 description 1
- QWYVCFPJEIVEAU-HXUWFJFHSA-N tert-butyl n-[(3r)-1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-[[3-(trifluoromethyl)isoquinolin-1-yl]methyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=C(N=3)C(F)(F)F)C(=O)C=2N(CC#CC)C=1N1CCC[C@@H](NC(=O)OC(C)(C)C)C1 QWYVCFPJEIVEAU-HXUWFJFHSA-N 0.000 description 1
- NDVNVORHXGSIPU-FQEVSTJZSA-N tert-butyl n-[(3s)-1-(7-but-2-ynyl-3-methyl-2,6-dioxo-1-phenacylpurin-8-yl)piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1 NDVNVORHXGSIPU-FQEVSTJZSA-N 0.000 description 1
- PQMMRCVKDSTGNG-SFHVURJKSA-N tert-butyl n-[(3s)-1-[1-[2-(1,3-benzodioxol-4-yl)-2-oxoethyl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC(=O)C=3C=4OCOC=4C=CC=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@H](NC(=O)OC(C)(C)C)C1 PQMMRCVKDSTGNG-SFHVURJKSA-N 0.000 description 1
- OOACCIVEOZYSJF-NRFANRHFSA-N tert-butyl n-[(3s)-1-[1-[2-(2-acetamidophenyl)-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3C[C@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1NC(C)=O OOACCIVEOZYSJF-NRFANRHFSA-N 0.000 description 1
- GKYJZNLVRGBMJA-DUIUGDAFSA-N tert-butyl n-[(3s)-1-[1-[2-(2-acetamidophenyl)-2-oxoethyl]-7-[(e)-but-2-enyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(C/C=C/C)C(N3C[C@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1NC(C)=O GKYJZNLVRGBMJA-DUIUGDAFSA-N 0.000 description 1
- PBZLEUCNUIWWHC-IBGZPJMESA-N tert-butyl n-[(3s)-1-[1-[2-(2-aminophenyl)-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3C[C@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1N PBZLEUCNUIWWHC-IBGZPJMESA-N 0.000 description 1
- LFEUCHARDAQECR-DKFQHHCZSA-N tert-butyl n-[(3s)-1-[1-[2-(2-aminophenyl)-2-oxoethyl]-7-[(e)-but-2-enyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(C/C=C/C)C(N3C[C@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1N LFEUCHARDAQECR-DKFQHHCZSA-N 0.000 description 1
- YDJDBKTWGFBOPV-IBGZPJMESA-N tert-butyl n-[(3s)-1-[1-[2-(2-hydroxyphenyl)-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3C[C@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1O YDJDBKTWGFBOPV-IBGZPJMESA-N 0.000 description 1
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- RFAUTJYAQNNKDF-OEAKIKGJSA-N tert-butyl n-[(3s)-1-[7-[(e)-but-2-enyl]-1-[2-[2-[2-(ethylamino)-2-oxoethoxy]phenyl]-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CCNC(=O)COC1=CC=CC=C1C(=O)CN1C(=O)C(N(C\C=C\C)C(N2C[C@H](CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O RFAUTJYAQNNKDF-OEAKIKGJSA-N 0.000 description 1
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- SHRMUBVUMXDVPY-JCOOBLOPSA-N tert-butyl n-[(3s)-1-[7-[(e)-but-2-enyl]-3-methyl-2,6-dioxo-1-[2-oxo-2-[2-(propanoylamino)phenyl]ethyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound CCC(=O)NC1=CC=CC=C1C(=O)CN1C(=O)C(N(C\C=C\C)C(N2C[C@H](CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O SHRMUBVUMXDVPY-JCOOBLOPSA-N 0.000 description 1
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- ADOLZOPNKNMYRN-QFIPXVFZSA-N tert-butyl n-[(3s)-1-[7-but-2-ynyl-1-[(4-methoxynaphthalen-1-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C12=CC=CC=C2C(OC)=CC=C1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCC[C@H](NC(=O)OC(C)(C)C)C1 ADOLZOPNKNMYRN-QFIPXVFZSA-N 0.000 description 1
- XUWMHIOBVSWHCE-KRWDZBQOSA-N tert-butyl n-[(3s)-1-[7-but-2-ynyl-1-[2-(2,2-difluoro-1,3-benzodioxol-4-yl)-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC(=O)C=3C=4OC(F)(F)OC=4C=CC=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@H](NC(=O)OC(C)(C)C)C1 XUWMHIOBVSWHCE-KRWDZBQOSA-N 0.000 description 1
- HTACRSYPEXPVPQ-IBGZPJMESA-N tert-butyl n-[(3s)-1-[7-but-2-ynyl-1-[2-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC(=O)C=3C=4OCCOC=4C=CC=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@H](NC(=O)OC(C)(C)C)C1 HTACRSYPEXPVPQ-IBGZPJMESA-N 0.000 description 1
- RXRMFGGOINGAOV-SFHVURJKSA-N tert-butyl n-[(3s)-1-[7-but-2-ynyl-1-[2-(2-hydroxyphenyl)-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1O RXRMFGGOINGAOV-SFHVURJKSA-N 0.000 description 1
- IGEXTOXNTIQTSL-NRFANRHFSA-N tert-butyl n-[(3s)-1-[7-but-2-ynyl-1-[2-[2-[2-(ethylamino)-2-oxoethoxy]phenyl]-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CCNC(=O)COC1=CC=CC=C1C(=O)CN1C(=O)C(N(CC#CC)C(N2C[C@H](CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O IGEXTOXNTIQTSL-NRFANRHFSA-N 0.000 description 1
- AAMOFATWOXYVIJ-QFIPXVFZSA-N tert-butyl n-[(3s)-1-[7-but-2-ynyl-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@H](NC(=O)OC(C)(C)C)C1 AAMOFATWOXYVIJ-QFIPXVFZSA-N 0.000 description 1
- QYYOKJZHSMMBRR-NRFANRHFSA-N tert-butyl n-[(3s)-1-[7-but-2-ynyl-3-methyl-1-[(4-methylisoquinolin-1-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(C)=CN=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@H](NC(=O)OC(C)(C)C)C1 QYYOKJZHSMMBRR-NRFANRHFSA-N 0.000 description 1
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- GTQRYYITVWWQSK-SFHVURJKSA-N tert-butyl n-[(3s)-1-[7-but-2-ynyl-3-methyl-1-[2-(2-nitrophenyl)-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1[N+]([O-])=O GTQRYYITVWWQSK-SFHVURJKSA-N 0.000 description 1
- NHLCQOFYKHZAHJ-NRFANRHFSA-N tert-butyl n-[(3s)-1-[7-but-2-ynyl-3-methyl-1-[2-[2-(2-methylpropanoylamino)phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1NC(=O)C(C)C NHLCQOFYKHZAHJ-NRFANRHFSA-N 0.000 description 1
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- JFUAYBBHAABEII-FQEVSTJZSA-N tert-butyl n-[(3s)-1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-(quinazolin-2-ylmethyl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=CN=3)C(=O)C=2N(CC#CC)C=1N1CCC[C@H](NC(=O)OC(C)(C)C)C1 JFUAYBBHAABEII-FQEVSTJZSA-N 0.000 description 1
- GEKDBUOOXAPXBX-DEOSSOPVSA-N tert-butyl n-[(3s)-1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-[(4-phenylquinazolin-2-yl)methyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3C[C@H](CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(N=C1C=CC=CC1=1)=NC=1C1=CC=CC=C1 GEKDBUOOXAPXBX-DEOSSOPVSA-N 0.000 description 1
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- ACBRZJMXXPNWSU-UHFFFAOYSA-N tert-butyl n-[1-(7-but-2-ynyl-3-cyclopropyl-2,6-dioxopurin-8-yl)piperidin-3-yl]carbamate Chemical compound O=C1NC(=O)C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N1C1CC1 ACBRZJMXXPNWSU-UHFFFAOYSA-N 0.000 description 1
- NDVNVORHXGSIPU-UHFFFAOYSA-N tert-butyl n-[1-(7-but-2-ynyl-3-methyl-2,6-dioxo-1-phenacylpurin-8-yl)piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1 NDVNVORHXGSIPU-UHFFFAOYSA-N 0.000 description 1
- YGTIPELGJHFPHX-UHFFFAOYSA-N tert-butyl n-[1-[1-(1-benzothiophen-3-ylmethyl)-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4SC=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 YGTIPELGJHFPHX-UHFFFAOYSA-N 0.000 description 1
- MSJTYGJIAUBBNE-UHFFFAOYSA-N tert-butyl n-[1-[1-(1h-benzimidazol-2-ylmethyl)-7-but-2-ynyl-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3NC4=CC=CC=C4N=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 MSJTYGJIAUBBNE-UHFFFAOYSA-N 0.000 description 1
- QENFSKREOVBEHA-UHFFFAOYSA-N tert-butyl n-[1-[1-(2-cyclohexyl-2-oxoethyl)-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1CCCCC1 QENFSKREOVBEHA-UHFFFAOYSA-N 0.000 description 1
- BHIPZMQUGZFQMJ-UHFFFAOYSA-N tert-butyl n-[1-[1-(3,3-dimethyl-2-oxobutyl)-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC(=O)C(C)(C)C)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 BHIPZMQUGZFQMJ-UHFFFAOYSA-N 0.000 description 1
- UBNXHBMUEWYBEO-UHFFFAOYSA-N tert-butyl n-[1-[1-(cinnolin-4-ylmethyl)-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4N=NC=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 UBNXHBMUEWYBEO-UHFFFAOYSA-N 0.000 description 1
- LAVBGSUGFOOIOW-UHFFFAOYSA-N tert-butyl n-[1-[1-(isoquinolin-3-ylmethyl)-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3N=CC4=CC=CC=C4C=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 LAVBGSUGFOOIOW-UHFFFAOYSA-N 0.000 description 1
- XCACLHCSWYUXIY-UHFFFAOYSA-N tert-butyl n-[1-[1-[(4-aminoquinazolin-2-yl)methyl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=C(N)N=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 XCACLHCSWYUXIY-UHFFFAOYSA-N 0.000 description 1
- GTEIBIXQCXUNEB-UHFFFAOYSA-N tert-butyl n-[1-[1-[(4-bromo-3-methoxyisoquinolin-1-yl)methyl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=12C=CC=CC2=C(Br)C(OC)=NC=1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCCC(NC(=O)OC(C)(C)C)C1 GTEIBIXQCXUNEB-UHFFFAOYSA-N 0.000 description 1
- WFOUXHIOVMYZTP-UHFFFAOYSA-N tert-butyl n-[1-[1-[(5-aminoisoquinolin-1-yl)methyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC(N)=C4C=CN=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 WFOUXHIOVMYZTP-UHFFFAOYSA-N 0.000 description 1
- BKNRGNALQKCBFP-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-(1,3-benzodioxol-4-yl)-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC(=O)C=3C=4OCOC=4C=CC=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 BKNRGNALQKCBFP-UHFFFAOYSA-N 0.000 description 1
- AMEGIGLDGRAOOW-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-(2,3-dihydro-1,4-benzodioxin-5-yl)-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC(=O)C=3C=4OCCOC=4C=CC=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 AMEGIGLDGRAOOW-UHFFFAOYSA-N 0.000 description 1
- KLLYGXTZIAHRDW-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-(2,3-dimethoxyphenyl)-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound COC1=CC=CC(C(=O)CN2C(C=3N(CC=C(C)C)C(N4CC(CCC4)NC(=O)OC(C)(C)C)=NC=3N(C)C2=O)=O)=C1OC KLLYGXTZIAHRDW-UHFFFAOYSA-N 0.000 description 1
- HLKSDBJNXDJXMD-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-(2,6-dimethoxyphenyl)-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound COC1=CC=CC(OC)=C1C(=O)CN1C(=O)C(N(CC=C(C)C)C(N2CC(CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O HLKSDBJNXDJXMD-UHFFFAOYSA-N 0.000 description 1
- CIKIIRTZGHXTED-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-(2-acetamidophenyl)-2-oxoethyl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1NC(C)=O CIKIIRTZGHXTED-UHFFFAOYSA-N 0.000 description 1
- BCCLFHKSZGAMGH-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-(2-amino-3-methoxyphenyl)-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound COC1=CC=CC(C(=O)CN2C(C=3N(CC=C(C)C)C(N4CC(CCC4)NC(=O)OC(C)(C)C)=NC=3N(C)C2=O)=O)=C1N BCCLFHKSZGAMGH-UHFFFAOYSA-N 0.000 description 1
- XICDDKPGSIJZLF-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-(2-aminoanilino)-2-oxoethyl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)NC1=CC=CC=C1N XICDDKPGSIJZLF-UHFFFAOYSA-N 0.000 description 1
- PBZLEUCNUIWWHC-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-(2-aminophenyl)-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1N PBZLEUCNUIWWHC-UHFFFAOYSA-N 0.000 description 1
- LHTAXYAKCYGEIT-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-(2-aminophenyl)-2-oxoethyl]-7-(cyclopenten-1-ylmethyl)-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1CCCC=1CN1C=2C(=O)N(CC(=O)C=3C(=CC=CC=3)N)C(=O)N(C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 LHTAXYAKCYGEIT-UHFFFAOYSA-N 0.000 description 1
- LFEUCHARDAQECR-VOTSOKGWSA-N tert-butyl n-[1-[1-[2-(2-aminophenyl)-2-oxoethyl]-7-[(e)-but-2-enyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(C/C=C/C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1N LFEUCHARDAQECR-VOTSOKGWSA-N 0.000 description 1
- XYWFRPTZXDEQMC-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-(2-aminophenyl)-2-oxoethyl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1N XYWFRPTZXDEQMC-UHFFFAOYSA-N 0.000 description 1
- BDJKEXFARMRVEU-VOTSOKGWSA-N tert-butyl n-[1-[1-[2-(2-benzamidophenyl)-2-oxoethyl]-7-[(e)-but-2-enyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(C/C=C/C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1NC(=O)C1=CC=CC=C1 BDJKEXFARMRVEU-VOTSOKGWSA-N 0.000 description 1
- QHYSLXZYAJYAFJ-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-(3-hydroxyphenyl)-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC(O)=C1 QHYSLXZYAJYAFJ-UHFFFAOYSA-N 0.000 description 1
- REEOTTBHTFUDCU-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-(3-methoxy-2-nitrophenyl)-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound COC1=CC=CC(C(=O)CN2C(C=3N(CC=C(C)C)C(N4CC(CCC4)NC(=O)OC(C)(C)C)=NC=3N(C)C2=O)=O)=C1[N+]([O-])=O REEOTTBHTFUDCU-UHFFFAOYSA-N 0.000 description 1
- DSBRUGDRJWUFPE-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-(dimethylamino)-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CC(C)=CCN1C=2C(=O)N(CC(=O)N(C)C)C(=O)N(C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 DSBRUGDRJWUFPE-UHFFFAOYSA-N 0.000 description 1
- BGXQXVMIJBWASZ-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-[2-(1-amino-1-oxopropan-2-yl)oxyphenyl]-2-oxoethyl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1OC(C)C(N)=O BGXQXVMIJBWASZ-UHFFFAOYSA-N 0.000 description 1
- PXUXSGRAHCFXTK-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-[2-(2-amino-2-oxoethoxy)phenyl]-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1OCC(N)=O PXUXSGRAHCFXTK-UHFFFAOYSA-N 0.000 description 1
- YVGYSCHSVDDVCR-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-[2-(2-amino-2-oxoethoxy)phenyl]-2-oxoethyl]-7-but-2-ynyl-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1OCC(N)=O YVGYSCHSVDDVCR-UHFFFAOYSA-N 0.000 description 1
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- OLVKTQYDNBUFLU-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-[2-(dimethylcarbamoyl)phenyl]-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CN(C)C(=O)C1=CC=CC=C1C(=O)CN1C(=O)C(N(CC=C(C)C)C(N2CC(CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O OLVKTQYDNBUFLU-UHFFFAOYSA-N 0.000 description 1
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- ZHKBUNREDGDIHM-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-[2-[2-(dimethylamino)-2-oxoethoxy]phenyl]-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CN(C)C(=O)COC1=CC=CC=C1C(=O)CN1C(=O)C(N(CC=C(C)C)C(N2CC(CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O ZHKBUNREDGDIHM-UHFFFAOYSA-N 0.000 description 1
- JZWAANDVSRNUDO-UHFFFAOYSA-N tert-butyl n-[1-[1-[2-[3-(dimethylcarbamoyl)phenyl]-2-oxoethyl]-3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CN(C)C(=O)C1=CC=CC(C(=O)CN2C(C=3N(CC=C(C)C)C(N4CC(CCC4)NC(=O)OC(C)(C)C)=NC=3N(C)C2=O)=O)=C1 JZWAANDVSRNUDO-UHFFFAOYSA-N 0.000 description 1
- ATJMLNSSJLTHOF-UHFFFAOYSA-N tert-butyl n-[1-[3-(cyanomethyl)-7-(3-methylbut-2-enyl)-2,6-dioxo-1-phenacylpurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(CC#N)C(=O)N1CC(=O)C1=CC=CC=C1 ATJMLNSSJLTHOF-UHFFFAOYSA-N 0.000 description 1
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- WAXGXIZMFYWMHY-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-1-[2-[2-[2-(methylamino)-2-oxoethoxy]phenyl]-2-oxoethyl]-7-(3-methylbut-2-enyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CNC(=O)COC1=CC=CC=C1C(=O)CN1C(=O)C(N(CC=C(C)C)C(N2CC(CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O WAXGXIZMFYWMHY-UHFFFAOYSA-N 0.000 description 1
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- LDEWQWALLVFFMP-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-1-[(3-methyl-4-oxophthalazin-1-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(=O)N(C)N=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 LDEWQWALLVFFMP-UHFFFAOYSA-N 0.000 description 1
- ZGXDAHIEHZUYON-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-1-[(5-nitroisoquinolin-1-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC(=C4C=CN=3)[N+]([O-])=O)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 ZGXDAHIEHZUYON-UHFFFAOYSA-N 0.000 description 1
- MVCSMSRQEQLNDU-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-1-[2-(2-nitrophenyl)-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1[N+]([O-])=O MVCSMSRQEQLNDU-UHFFFAOYSA-N 0.000 description 1
- XMOSMSVYLXFHKS-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-1-[2-(3-methyl-2-oxo-1,3-benzoxazol-4-yl)-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC(=O)C=3C=4N(C)C(=O)OC=4C=CC=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 XMOSMSVYLXFHKS-UHFFFAOYSA-N 0.000 description 1
- ZZGVKHPZAZCPGU-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-1-[2-(3-methyl-2-oxo-1,3-benzoxazol-7-yl)-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC(=O)C=3C=4OC(=O)N(C)C=4C=CC=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 ZZGVKHPZAZCPGU-UHFFFAOYSA-N 0.000 description 1
- XHHMKLPBWRTDMA-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-1-[2-(3-methylsulfonylphenyl)-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC(S(C)(=O)=O)=C1 XHHMKLPBWRTDMA-UHFFFAOYSA-N 0.000 description 1
- LEFWRVPNZOHTHO-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-1-[2-(3-nitrophenyl)-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC([N+]([O-])=O)=C1 LEFWRVPNZOHTHO-UHFFFAOYSA-N 0.000 description 1
- UXPRJJXCAJAQKJ-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-1-[2-[2-(2-methylpropanoylamino)phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CC(C)C(=O)NC1=CC=CC=C1C(=O)CN1C(=O)C(N(CC=C(C)C)C(N2CC(CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O UXPRJJXCAJAQKJ-UHFFFAOYSA-N 0.000 description 1
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- LOBGZUUGDLXXSU-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-1-[2-[3-(methylcarbamoyl)phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CNC(=O)C1=CC=CC(C(=O)CN2C(C=3N(CC=C(C)C)C(N4CC(CCC4)NC(=O)OC(C)(C)C)=NC=3N(C)C2=O)=O)=C1 LOBGZUUGDLXXSU-UHFFFAOYSA-N 0.000 description 1
- GDZXVEHDCABHEA-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-1-[2-[3-(methylsulfanylmethoxy)phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CSCOC1=CC=CC(C(=O)CN2C(C=3N(CC=C(C)C)C(N4CC(CCC4)NC(=O)OC(C)(C)C)=NC=3N(C)C2=O)=O)=C1 GDZXVEHDCABHEA-UHFFFAOYSA-N 0.000 description 1
- IHIJKCWEFUXBHE-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-1-[2-[3-(methylsulfinylmethoxy)phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC(OCS(C)=O)=C1 IHIJKCWEFUXBHE-UHFFFAOYSA-N 0.000 description 1
- WWGPVNRUXJPEDB-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-1-[2-[3-(morpholine-4-carbonyl)phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C(C=1)=CC=CC=1C(=O)N1CCOCC1 WWGPVNRUXJPEDB-UHFFFAOYSA-N 0.000 description 1
- RAAJSNZAJQGURT-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxo-1-(1-oxo-1-phenylpropan-2-yl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1N(C)C=2N=C(N3CC(CCC3)NC(=O)OC(C)(C)C)N(CC=C(C)C)C=2C(=O)N1C(C)C(=O)C1=CC=CC=C1 RAAJSNZAJQGURT-UHFFFAOYSA-N 0.000 description 1
- UOQHAXFRWQZCPE-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxo-1-(2-oxo-2-piperidin-1-ylethyl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)N1CCCCC1 UOQHAXFRWQZCPE-UHFFFAOYSA-N 0.000 description 1
- HKRFHNFHWBPSDR-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxo-1-(2-oxo-2-pyrrolidin-1-ylethyl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)N1CCCC1 HKRFHNFHWBPSDR-UHFFFAOYSA-N 0.000 description 1
- ITENZOOWGQRYLP-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxo-1-(quinazolin-4-ylmethyl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4N=CN=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 ITENZOOWGQRYLP-UHFFFAOYSA-N 0.000 description 1
- GZCTXHGXTJKNSR-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxo-1-[(2-oxochromen-4-yl)methyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C=4C=CC=CC=4OC(=O)C=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 GZCTXHGXTJKNSR-UHFFFAOYSA-N 0.000 description 1
- GUYRUBCPOQQSQG-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxo-1-[(3-phenyl-1,2,4-oxadiazol-5-yl)methyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(ON=1)=NC=1C1=CC=CC=C1 GUYRUBCPOQQSQG-UHFFFAOYSA-N 0.000 description 1
- IWEJHYUZDNSOEF-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxo-1-[(4-oxo-3h-phthalazin-1-yl)methyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(=O)NN=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 IWEJHYUZDNSOEF-UHFFFAOYSA-N 0.000 description 1
- YNOSVMIFBSMKIP-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxo-1-[(4-phenylphenyl)methyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(C=C1)=CC=C1C1=CC=CC=C1 YNOSVMIFBSMKIP-UHFFFAOYSA-N 0.000 description 1
- QEFPUNCCUIUVKM-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxo-1-[(4-phenylpyridin-2-yl)methyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(N=CC=1)=CC=1C1=CC=CC=C1 QEFPUNCCUIUVKM-UHFFFAOYSA-N 0.000 description 1
- IEQOFOJIXHMSBS-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxo-1-[(5-phenylpyridin-2-yl)methyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(N=C1)=CC=C1C1=CC=CC=C1 IEQOFOJIXHMSBS-UHFFFAOYSA-N 0.000 description 1
- KENSGPCARNEVFW-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxo-1-[2-oxo-2-[2-(propanoylamino)phenyl]ethyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound CCC(=O)NC1=CC=CC=C1C(=O)CN1C(=O)C(N(CC=C(C)C)C(N2CC(CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O KENSGPCARNEVFW-UHFFFAOYSA-N 0.000 description 1
- IDEXWCBYHNLTHE-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxo-1-[2-oxo-2-[3-(2-oxoimidazolidin-1-yl)phenyl]ethyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C(C=1)=CC=CC=1N1CCNC1=O IDEXWCBYHNLTHE-UHFFFAOYSA-N 0.000 description 1
- NKVHJFSNENYNNZ-UHFFFAOYSA-N tert-butyl n-[1-[3-methyl-7-(3-methylbut-2-enyl)-2,6-dioxo-1-[[4-oxo-3-(2-trimethylsilylethoxymethyl)phthalazin-1-yl]methyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(=O)N(COCC[Si](C)(C)C)N=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 NKVHJFSNENYNNZ-UHFFFAOYSA-N 0.000 description 1
- KDXZQXUPDBEGDS-FBCYGCLPSA-N tert-butyl n-[1-[3-methyl-7-[(e)-2-methylbut-2-enyl]-2,6-dioxo-1-phenacylpurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC(/C)=C/C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1 KDXZQXUPDBEGDS-FBCYGCLPSA-N 0.000 description 1
- KDXZQXUPDBEGDS-GXHLCREISA-N tert-butyl n-[1-[3-methyl-7-[(z)-2-methylbut-2-enyl]-2,6-dioxo-1-phenacylpurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC(\C)=C/C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1 KDXZQXUPDBEGDS-GXHLCREISA-N 0.000 description 1
- RNMLHWFSQVAKHV-UHFFFAOYSA-N tert-butyl n-[1-[7-(2,3-dimethylbut-2-enyl)-3-methyl-2,6-dioxo-1-phenacylpurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC(C)=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1 RNMLHWFSQVAKHV-UHFFFAOYSA-N 0.000 description 1
- ILMBROFYYKTCIB-UHFFFAOYSA-N tert-butyl n-[1-[7-(2,3-dimethylbut-2-enyl)-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)NC(=O)C=2N(CC(C)=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 ILMBROFYYKTCIB-UHFFFAOYSA-N 0.000 description 1
- COWWHLDTRDXSGM-UHFFFAOYSA-N tert-butyl n-[1-[7-(3-methylbut-2-enyl)-1-[(2-methyl-1-oxoisoquinolin-4-yl)methyl]-2,6-dioxo-3h-purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2NC(=O)N(CC=3C4=CC=CC=C4C(=O)N(C)C=3)C(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 COWWHLDTRDXSGM-UHFFFAOYSA-N 0.000 description 1
- PBWLDAVXSGYFFS-UHFFFAOYSA-N tert-butyl n-[1-[7-(3-methylbut-2-enyl)-2,6-dioxo-1-phenacyl-3-(2-trimethylsilylethoxymethyl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(COCC[Si](C)(C)C)C(=O)N1CC(=O)C1=CC=CC=C1 PBWLDAVXSGYFFS-UHFFFAOYSA-N 0.000 description 1
- KJBYGYWHWGIPPE-UHFFFAOYSA-N tert-butyl n-[1-[7-(3-methylbut-2-enyl)-2,6-dioxo-1-phenacyl-3h-purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC=C(C)C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2NC(=O)N1CC(=O)C1=CC=CC=C1 KJBYGYWHWGIPPE-UHFFFAOYSA-N 0.000 description 1
- COXNJUOKZZWFPB-UHFFFAOYSA-N tert-butyl n-[1-[7-(3-methylbut-2-enyl)-2,6-dioxo-3-(2-trimethylsilylethoxymethyl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(COCC[Si](C)(C)C)C(=O)NC(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 COXNJUOKZZWFPB-UHFFFAOYSA-N 0.000 description 1
- JGMFMWWOUIEEQP-UHFFFAOYSA-N tert-butyl n-[1-[7-(3-methylbut-2-enyl)-2,6-dioxo-3h-purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2NC(=O)NC(=O)C=2N(CC=C(C)C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 JGMFMWWOUIEEQP-UHFFFAOYSA-N 0.000 description 1
- BMTYAODFVANLBH-UHFFFAOYSA-N tert-butyl n-[1-[7-(cyclopenten-1-ylmethyl)-1-[2-(2-hydroxyphenyl)-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1CCCC=1CN1C=2C(=O)N(CC(=O)C=3C(=CC=CC=3)O)C(=O)N(C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 BMTYAODFVANLBH-UHFFFAOYSA-N 0.000 description 1
- UBUZNVXNXWBITR-UHFFFAOYSA-N tert-butyl n-[1-[7-(cyclopenten-1-ylmethyl)-1-[2-[2-(cyclopropanecarbonylamino)phenyl]-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1CCCC=1CN1C=2C(=O)N(CC(=O)C=3C(=CC=CC=3)NC(=O)C3CC3)C(=O)N(C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 UBUZNVXNXWBITR-UHFFFAOYSA-N 0.000 description 1
- CVYOXNASRFXMTF-UHFFFAOYSA-N tert-butyl n-[1-[7-(cyclopenten-1-ylmethyl)-3-methyl-1-[2-[2-[2-(methylamino)-2-oxoethoxy]phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CNC(=O)COC1=CC=CC=C1C(=O)CN1C(=O)C(N(CC=2CCCC=2)C(N2CC(CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O CVYOXNASRFXMTF-UHFFFAOYSA-N 0.000 description 1
- MADGZLZFOMCKJD-UHFFFAOYSA-N tert-butyl n-[1-[7-(cyclopenten-1-ylmethyl)-3-methyl-2,6-dioxo-1-phenacylpurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1CCCC=1CN1C=2C(=O)N(CC(=O)C=3C=CC=CC=3)C(=O)N(C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 MADGZLZFOMCKJD-UHFFFAOYSA-N 0.000 description 1
- LXRSYECGYLOEDX-UHFFFAOYSA-N tert-butyl n-[1-[7-(furan-2-ylmethyl)-3-methyl-2,6-dioxo-1-phenacylpurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1C=COC=1CN1C=2C(=O)N(CC(=O)C=3C=CC=CC=3)C(=O)N(C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 LXRSYECGYLOEDX-UHFFFAOYSA-N 0.000 description 1
- LUZSXJUPOIFKFA-UHFFFAOYSA-N tert-butyl n-[1-[7-[(2-bromophenyl)methyl]-1,3-dimethyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1C=CC=C(Br)C=1CN1C=2C(=O)N(C)C(=O)N(C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 LUZSXJUPOIFKFA-UHFFFAOYSA-N 0.000 description 1
- OOPDXQNJSWMYLE-UHFFFAOYSA-N tert-butyl n-[1-[7-[(2-chlorophenyl)methyl]-1,3-dimethyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1C=CC=C(Cl)C=1CN1C=2C(=O)N(C)C(=O)N(C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 OOPDXQNJSWMYLE-UHFFFAOYSA-N 0.000 description 1
- QYHDDGPOSXQWDF-UHFFFAOYSA-N tert-butyl n-[1-[7-[(2-cyanophenyl)methyl]-1-(2-methoxyethyl)-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1C=CC=C(C#N)C=1CN1C=2C(=O)N(CCOC)C(=O)N(C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 QYHDDGPOSXQWDF-UHFFFAOYSA-N 0.000 description 1
- GJTMDPMSKFSRRV-UHFFFAOYSA-N tert-butyl n-[1-[7-[(2-cyanophenyl)methyl]-1-methyl-2,6-dioxo-3-(2-trimethylsilylethoxymethyl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1C=CC=C(C#N)C=1CN1C=2C(=O)N(C)C(=O)N(COCC[Si](C)(C)C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 GJTMDPMSKFSRRV-UHFFFAOYSA-N 0.000 description 1
- SDUBJZNOSOSYCG-UHFFFAOYSA-N tert-butyl n-[1-[7-[(2-cyanophenyl)methyl]-1-methyl-2,6-dioxo-3-phenylpurin-8-yl]piperidin-3-yl]carbamate Chemical compound C1=2N=C(N3CC(CCC3)NC(=O)OC(C)(C)C)N(CC=3C(=CC=CC=3)C#N)C=2C(=O)N(C)C(=O)N1C1=CC=CC=C1 SDUBJZNOSOSYCG-UHFFFAOYSA-N 0.000 description 1
- VCDYCJSPNMTHKK-UHFFFAOYSA-N tert-butyl n-[1-[7-[(2-cyanophenyl)methyl]-1-methyl-2,6-dioxo-3-prop-2-enylpurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1C=CC=C(C#N)C=1CN1C=2C(=O)N(C)C(=O)N(CC=C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 VCDYCJSPNMTHKK-UHFFFAOYSA-N 0.000 description 1
- BBKIEGQSZRDDPM-UHFFFAOYSA-N tert-butyl n-[1-[7-[(2-cyanophenyl)methyl]-1-methyl-2,6-dioxo-3-prop-2-ynylpurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1C=CC=C(C#N)C=1CN1C=2C(=O)N(C)C(=O)N(CC#C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 BBKIEGQSZRDDPM-UHFFFAOYSA-N 0.000 description 1
- FKFKYSJONJQNNU-UHFFFAOYSA-N tert-butyl n-[1-[7-[(2-cyanophenyl)methyl]-1-methyl-2,6-dioxo-3-propan-2-ylpurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1C=CC=C(C#N)C=1CN1C=2C(=O)N(C)C(=O)N(C(C)C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 FKFKYSJONJQNNU-UHFFFAOYSA-N 0.000 description 1
- HPEQQFYYDMGEOD-UHFFFAOYSA-N tert-butyl n-[1-[7-[(2-cyanophenyl)methyl]-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C(C)=CC2=CC=CC=C2C=1CN(C(C=1N2CC=3C(=CC=CC=3)C#N)=O)C(=O)N(C)C=1N=C2N1CCCC(NC(=O)OC(C)(C)C)C1 HPEQQFYYDMGEOD-UHFFFAOYSA-N 0.000 description 1
- QUNOPHRBRIZZOW-UHFFFAOYSA-N tert-butyl n-[1-[7-[(2-cyanophenyl)methyl]-3-methyl-2,6-dioxo-1-(2-phenoxyethyl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1C=CC=C(C#N)C=1CN1C=2C(=O)N(CCOC=3C=CC=CC=3)C(=O)N(C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 QUNOPHRBRIZZOW-UHFFFAOYSA-N 0.000 description 1
- YCCMMCNGYDYTCM-UHFFFAOYSA-N tert-butyl n-[1-[7-[(2-cyanophenyl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=1C=CC=C(C#N)C=1CN1C=2C(=O)NC(=O)N(C)C=2N=C1N1CCCC(NC(=O)OC(C)(C)C)C1 YCCMMCNGYDYTCM-UHFFFAOYSA-N 0.000 description 1
- MLGPARVHAHUUTB-FRKPEAEDSA-N tert-butyl n-[1-[7-[(e)-but-1-enyl]-3-methyl-2,6-dioxo-1-phenacylpurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(/C=C/CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1 MLGPARVHAHUUTB-FRKPEAEDSA-N 0.000 description 1
- FDGPLVWOGVHXBM-VOTSOKGWSA-N tert-butyl n-[1-[7-[(e)-but-2-enyl]-1-(isoquinolin-1-ylmethyl)-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=CN=3)C(=O)C=2N(C/C=C/C)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 FDGPLVWOGVHXBM-VOTSOKGWSA-N 0.000 description 1
- PKHQSRYHZPLUKX-VOTSOKGWSA-N tert-butyl n-[1-[7-[(e)-but-2-enyl]-1-[2-(2-hydroxyphenyl)-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(C/C=C/C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1O PKHQSRYHZPLUKX-VOTSOKGWSA-N 0.000 description 1
- QHORXPBZCCDKKI-CMDGGOBGSA-N tert-butyl n-[1-[7-[(e)-but-2-enyl]-3-methyl-1-[2-[2-(2-methylpropanoylamino)phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(C/C=C/C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1NC(=O)C(C)C QHORXPBZCCDKKI-CMDGGOBGSA-N 0.000 description 1
- ONPJSYUMODSLHC-BQYQJAHWSA-N tert-butyl n-[1-[7-[(e)-but-2-enyl]-3-methyl-1-[2-[2-[2-(methylamino)-2-oxoethoxy]phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CNC(=O)COC1=CC=CC=C1C(=O)CN1C(=O)C(N(C\C=C\C)C(N2CC(CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O ONPJSYUMODSLHC-BQYQJAHWSA-N 0.000 description 1
- UJKIEIPDMMUQFJ-VOTSOKGWSA-N tert-butyl n-[1-[7-[(e)-but-2-enyl]-3-methyl-2,6-dioxo-1-phenacylpurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(C/C=C/C)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1 UJKIEIPDMMUQFJ-VOTSOKGWSA-N 0.000 description 1
- BQLYDCHAAWINTJ-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-(2-cyanoimino-2-phenylethyl)-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=NC#N)C1=CC=CC=C1 BQLYDCHAAWINTJ-UHFFFAOYSA-N 0.000 description 1
- UVPCRPRNGGKEIL-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-(imidazo[1,2-a]pyridin-2-ylmethyl)-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CN4C=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 UVPCRPRNGGKEIL-UHFFFAOYSA-N 0.000 description 1
- GTUJIRJFCAIIIS-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-(isoquinolin-1-ylmethyl)-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=CN=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 GTUJIRJFCAIIIS-UHFFFAOYSA-N 0.000 description 1
- CZVIBNGOGNRTDO-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[(2,3-dimethylquinoxalin-6-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C=C4N=C(C)C(C)=NC4=CC=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 CZVIBNGOGNRTDO-UHFFFAOYSA-N 0.000 description 1
- BFNNYKRIUWEYBW-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[(2-cyano-1-benzofuran-3-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4OC=3C#N)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 BFNNYKRIUWEYBW-UHFFFAOYSA-N 0.000 description 1
- QDAQALIGBUPAKU-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[(2-methoxynaphthalen-1-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound COC1=CC=C2C=CC=CC2=C1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCCC(NC(=O)OC(C)(C)C)C1 QDAQALIGBUPAKU-UHFFFAOYSA-N 0.000 description 1
- DLAGCJRDJNUMIQ-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[(2-methyl-1-oxoisoquinolin-4-yl)methyl]-2,6-dioxo-3h-purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2NC(=O)N(CC=3C4=CC=CC=C4C(=O)N(C)C=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 DLAGCJRDJNUMIQ-UHFFFAOYSA-N 0.000 description 1
- PYRDKNIQKOVGAT-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[(3,4-dimethyl-5,6,7,8-tetrahydroisoquinolin-1-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C=4CCCCC=4C(C)=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 PYRDKNIQKOVGAT-UHFFFAOYSA-N 0.000 description 1
- GYKIWRBTPQRTIF-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[(3-methoxynaphthalen-2-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound COC1=CC2=CC=CC=C2C=C1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCCC(NC(=O)OC(C)(C)C)C1 GYKIWRBTPQRTIF-UHFFFAOYSA-N 0.000 description 1
- LVFJPIWBEHBWDE-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[(4-chloro-3-methoxyisoquinolin-1-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C=12C=CC=CC2=C(Cl)C(OC)=NC=1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCCC(NC(=O)OC(C)(C)C)C1 LVFJPIWBEHBWDE-UHFFFAOYSA-N 0.000 description 1
- MBUSBNKEWWHEPI-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[(4-ethoxyquinazolin-2-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C2=CC=CC=C2C(OCC)=NC=1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCCC(NC(=O)OC(C)(C)C)C1 MBUSBNKEWWHEPI-UHFFFAOYSA-N 0.000 description 1
- ADOLZOPNKNMYRN-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[(4-methoxynaphthalen-1-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C12=CC=CC=C2C(OC)=CC=C1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCCC(NC(=O)OC(C)(C)C)C1 ADOLZOPNKNMYRN-UHFFFAOYSA-N 0.000 description 1
- PKYGRGBHASQKNC-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[(5-methoxyisoquinolin-8-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C12=CN=CC=C2C(OC)=CC=C1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCCC(NC(=O)OC(C)(C)C)C1 PKYGRGBHASQKNC-UHFFFAOYSA-N 0.000 description 1
- BOEAQMVGAJBWHB-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[(5-methoxyquinolin-8-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C12=NC=CC=C2C(OC)=CC=C1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCCC(NC(=O)OC(C)(C)C)C1 BOEAQMVGAJBWHB-UHFFFAOYSA-N 0.000 description 1
- CTYUBSNJAIPAGC-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[(8-methoxyquinolin-5-yl)methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound C12=CC=CN=C2C(OC)=CC=C1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCCC(NC(=O)OC(C)(C)C)C1 CTYUBSNJAIPAGC-UHFFFAOYSA-N 0.000 description 1
- YKTRWBHCWVZFOA-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[2-(1,3-dimethyl-2-oxobenzimidazol-4-yl)-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC(=O)C=3C=4N(C)C(=O)N(C)C=4C=CC=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 YKTRWBHCWVZFOA-UHFFFAOYSA-N 0.000 description 1
- DSOCACVNIIQZHK-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[2-[2-(cyanomethoxy)phenyl]-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1OCC#N DSOCACVNIIQZHK-UHFFFAOYSA-N 0.000 description 1
- IGEXTOXNTIQTSL-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[2-[2-[2-(ethylamino)-2-oxoethoxy]phenyl]-2-oxoethyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CCNC(=O)COC1=CC=CC=C1C(=O)CN1C(=O)C(N(CC#CC)C(N2CC(CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O IGEXTOXNTIQTSL-UHFFFAOYSA-N 0.000 description 1
- SFALGRMIDSDAKN-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[[1-(2-cyanoethyl)benzimidazol-2-yl]methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3N(C4=CC=CC=C4N=3)CCC#N)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 SFALGRMIDSDAKN-UHFFFAOYSA-N 0.000 description 1
- RTAYIAUOXYYZBT-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[[1-(2-cyanopropan-2-yl)isoquinolin-3-yl]methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C(C4=CC=CC=C4C=3)C(C)(C)C#N)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 RTAYIAUOXYYZBT-UHFFFAOYSA-N 0.000 description 1
- XQBXXGRDEXLEIQ-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[[2-(2,2-dimethylpropanoyl)-1-benzofuran-3-yl]methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4OC=3C(=O)C(C)(C)C)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 XQBXXGRDEXLEIQ-UHFFFAOYSA-N 0.000 description 1
- WLZOTUYUZMVQBZ-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[[4-(dimethylamino)naphthalen-1-yl]methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(N(C)C)=CC=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 WLZOTUYUZMVQBZ-UHFFFAOYSA-N 0.000 description 1
- VYRFENWPHQECHR-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-1-[[4-(dimethylamino)quinazolin-2-yl]methyl]-3-methyl-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=C(N(C)C)N=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 VYRFENWPHQECHR-UHFFFAOYSA-N 0.000 description 1
- ATKKEHMAJJJHPQ-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-cyclopropyl-1-[(3-methylisoquinolin-1-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1N(CC=2C3=CC=CC=C3C=C(C)N=2)C(=O)C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N1C1CC1 ATKKEHMAJJJHPQ-UHFFFAOYSA-N 0.000 description 1
- MJVNGTMBPLUGSO-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-cyclopropyl-2,6-dioxo-1-[(4-phenylquinazolin-2-yl)methyl]purin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1N(CC=2N=C3C=CC=CC3=C(C=3C=CC=CC=3)N=2)C(=O)C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N1C1CC1 MJVNGTMBPLUGSO-UHFFFAOYSA-N 0.000 description 1
- XVPQSFBSKCSQJY-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-(1,5-naphthyridin-2-ylmethyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=NC4=CC=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 XVPQSFBSKCSQJY-UHFFFAOYSA-N 0.000 description 1
- JKYKRTFPIVDHRL-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-(1,6-naphthyridin-5-ylmethyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CN=C4C=CN=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 JKYKRTFPIVDHRL-UHFFFAOYSA-N 0.000 description 1
- PUPRDLFDROZSON-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-(1,8-naphthyridin-2-ylmethyl)-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4N=CC=CC4=CC=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 PUPRDLFDROZSON-UHFFFAOYSA-N 0.000 description 1
- ZMSCIIHKSABKIQ-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[(1-methyl-2-oxoquinolin-4-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4N(C)C(=O)C=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 ZMSCIIHKSABKIQ-UHFFFAOYSA-N 0.000 description 1
- GJIZRDNRGGUOJT-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[(1-methyl-2-oxoquinolin-6-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C=C4C=CC(=O)N(C)C4=CC=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 GJIZRDNRGGUOJT-UHFFFAOYSA-N 0.000 description 1
- FXYGVSMRJWIPCW-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[(1-methylbenzimidazol-2-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3N(C4=CC=CC=C4N=3)C)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 FXYGVSMRJWIPCW-UHFFFAOYSA-N 0.000 description 1
- NCSSPTJFQWDRDC-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[(2-methyl-1,3-benzothiazol-6-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C=C4SC(C)=NC4=CC=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 NCSSPTJFQWDRDC-UHFFFAOYSA-N 0.000 description 1
- RZNZHYLWLHHWQQ-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[(2-methylnaphthalen-1-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=CC=3C)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 RZNZHYLWLHHWQQ-UHFFFAOYSA-N 0.000 description 1
- AAMOFATWOXYVIJ-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[(3-methylisoquinolin-1-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C=C(C)N=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 AAMOFATWOXYVIJ-UHFFFAOYSA-N 0.000 description 1
- JOMHDULOSAEZBE-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[(3-methylquinoxalin-2-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C(=NC4=CC=CC=C4N=3)C)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 JOMHDULOSAEZBE-UHFFFAOYSA-N 0.000 description 1
- QYYOKJZHSMMBRR-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[(4-methylisoquinolin-1-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(C)=CN=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 QYYOKJZHSMMBRR-UHFFFAOYSA-N 0.000 description 1
- KNLNFPZYNXCOQI-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[(4-methylphthalazin-1-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC=C4C(C)=NN=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 KNLNFPZYNXCOQI-UHFFFAOYSA-N 0.000 description 1
- IIXXXJZKQFLCDZ-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[(4-morpholin-4-ylquinazolin-2-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(N=C1C=CC=CC1=1)=NC=1N1CCOCC1 IIXXXJZKQFLCDZ-UHFFFAOYSA-N 0.000 description 1
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- RECLHFQAJZUBKN-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[(5-nitronaphthalen-1-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C4=CC=CC(=C4C=CC=3)[N+]([O-])=O)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 RECLHFQAJZUBKN-UHFFFAOYSA-N 0.000 description 1
- NOZWKVXKRXFUKL-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[(8-methylquinoxalin-6-yl)methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C=C4N=CC=NC4=C(C)C=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 NOZWKVXKRXFUKL-UHFFFAOYSA-N 0.000 description 1
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- NHLCQOFYKHZAHJ-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[2-[2-(2-methylpropanoylamino)phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1NC(=O)C(C)C NHLCQOFYKHZAHJ-UHFFFAOYSA-N 0.000 description 1
- ABBNNWHMTFSEPI-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[2-[2-(2-morpholin-4-yl-2-oxoethoxy)phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1OCC(=O)N1CCOCC1 ABBNNWHMTFSEPI-UHFFFAOYSA-N 0.000 description 1
- KHSSSUHAHMFXGO-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[2-[2-(methylsulfanylmethoxy)phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CSCOC1=CC=CC=C1C(=O)CN1C(=O)C(N(CC#CC)C(N2CC(CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O KHSSSUHAHMFXGO-UHFFFAOYSA-N 0.000 description 1
- HBVZLPHQJHNFPU-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[2-[2-(methylsulfinylmethoxy)phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound O=C1C=2N(CC#CC)C(N3CC(CCC3)NC(=O)OC(C)(C)C)=NC=2N(C)C(=O)N1CC(=O)C1=CC=CC=C1OCS(C)=O HBVZLPHQJHNFPU-UHFFFAOYSA-N 0.000 description 1
- GWDNCFCAWWMWJO-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[2-[2-[2-(methylamino)-2-oxoethoxy]phenyl]-2-oxoethyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound CNC(=O)COC1=CC=CC=C1C(=O)CN1C(=O)C(N(CC#CC)C(N2CC(CCC2)NC(=O)OC(C)(C)C)=N2)=C2N(C)C1=O GWDNCFCAWWMWJO-UHFFFAOYSA-N 0.000 description 1
- UACOCVHKKVTLIR-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[[1-[2-(methylamino)-2-oxoethyl]benzimidazol-2-yl]methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C2=CC=CC=C2N(CC(=O)NC)C=1CN(C(C=1N2CC#CC)=O)C(=O)N(C)C=1N=C2N1CCCC(NC(=O)OC(C)(C)C)C1 UACOCVHKKVTLIR-UHFFFAOYSA-N 0.000 description 1
- YLAXGLJRBJGUKG-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-1-[[2-methyl-1-(2-trimethylsilylethoxymethyl)benzimidazol-5-yl]methyl]-2,6-dioxopurin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C=C4N=C(C)N(COCC[Si](C)(C)C)C4=CC=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 YLAXGLJRBJGUKG-UHFFFAOYSA-N 0.000 description 1
- AJEKJFIHZVHLFY-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-(pyrazolo[1,5-a]pyridin-2-ylmethyl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC3=NN4C=CC=CC4=C3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 AJEKJFIHZVHLFY-UHFFFAOYSA-N 0.000 description 1
- JFUAYBBHAABEII-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-(quinazolin-2-ylmethyl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3N=C4C=CC=CC4=CN=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 JFUAYBBHAABEII-UHFFFAOYSA-N 0.000 description 1
- NQCUSZYDXXLSJI-UHFFFAOYSA-N tert-butyl n-[1-[7-but-2-ynyl-3-methyl-2,6-dioxo-1-(quinolin-3-ylmethyl)purin-8-yl]piperidin-3-yl]carbamate Chemical compound N=1C=2N(C)C(=O)N(CC=3C=C4C=CC=CC4=NC=3)C(=O)C=2N(CC#CC)C=1N1CCCC(NC(=O)OC(C)(C)C)C1 NQCUSZYDXXLSJI-UHFFFAOYSA-N 0.000 description 1
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- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
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- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
- C07D473/12—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1, 3, and 7, e.g. caffeine
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10238243A DE10238243A1 (de) | 2002-08-21 | 2002-08-21 | 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
DE10312353A DE10312353A1 (de) | 2003-03-20 | 2003-03-20 | 8-[3-Amino-piperidin-1-yl]-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
PCT/EP2003/009127 WO2004018468A2 (de) | 2002-08-21 | 2003-08-18 | 8-[3-amino-piperidin-1-yl]-xanthine, deren herstellung und deren verwendung als arzneimittel |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
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JP2008152875A Division JP4971251B2 (ja) | 2002-08-21 | 2008-06-11 | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
JP2008267827A Division JP5351486B2 (ja) | 2002-08-21 | 2008-10-16 | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
Publications (3)
Publication Number | Publication Date |
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JP2006503013A JP2006503013A (ja) | 2006-01-26 |
JP2006503013A5 JP2006503013A5 (uk) | 2008-08-21 |
JP4233524B2 true JP4233524B2 (ja) | 2009-03-04 |
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JP2004530186A Expired - Lifetime JP4233524B2 (ja) | 2002-08-21 | 2003-08-18 | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
JP2008152875A Expired - Lifetime JP4971251B2 (ja) | 2002-08-21 | 2008-06-11 | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
JP2008267827A Expired - Lifetime JP5351486B2 (ja) | 2002-08-21 | 2008-10-16 | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
JP2012090295A Expired - Lifetime JP5623459B2 (ja) | 2002-08-21 | 2012-04-11 | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
JP2014108575A Expired - Lifetime JP6114231B2 (ja) | 2002-08-21 | 2014-05-26 | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
JP2016132807A Expired - Lifetime JP6139004B2 (ja) | 2002-08-21 | 2016-07-04 | 1−[([1,5]ナフチリジン−2−イル)メチル]−3−メチル−7−(2−ブチン−1−イル)−8−((r)−3−アミノ−ピペリジン−1−イル)−キサンチン、又はその塩 |
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JP2008152875A Expired - Lifetime JP4971251B2 (ja) | 2002-08-21 | 2008-06-11 | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
JP2008267827A Expired - Lifetime JP5351486B2 (ja) | 2002-08-21 | 2008-10-16 | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
JP2012090295A Expired - Lifetime JP5623459B2 (ja) | 2002-08-21 | 2012-04-11 | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
JP2014108575A Expired - Lifetime JP6114231B2 (ja) | 2002-08-21 | 2014-05-26 | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
JP2016132807A Expired - Lifetime JP6139004B2 (ja) | 2002-08-21 | 2016-07-04 | 1−[([1,5]ナフチリジン−2−イル)メチル]−3−メチル−7−(2−ブチン−1−イル)−8−((r)−3−アミノ−ピペリジン−1−イル)−キサンチン、又はその塩 |
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EP (6) | EP2308878A3 (uk) |
JP (6) | JP4233524B2 (uk) |
KR (2) | KR101111101B1 (uk) |
CN (4) | CN107674077A (uk) |
AR (3) | AR041025A1 (uk) |
AT (1) | ATE453644T1 (uk) |
AU (2) | AU2003253418B2 (uk) |
BE (1) | BE2011C038I2 (uk) |
BR (2) | BR122012026540B8 (uk) |
CA (1) | CA2496249C (uk) |
CY (3) | CY1109928T1 (uk) |
DE (2) | DE50312295D1 (uk) |
DK (1) | DK1532149T3 (uk) |
EA (3) | EA016166B1 (uk) |
EC (2) | ECSP055617A (uk) |
EG (1) | EG25011A (uk) |
ES (1) | ES2339112T3 (uk) |
FR (1) | FR11C0052I2 (uk) |
HK (6) | HK1081552A1 (uk) |
HR (2) | HRP20050157B1 (uk) |
HU (1) | HUS1100028I1 (uk) |
IL (1) | IL166964A (uk) |
IN (2) | IN2015DN01133A (uk) |
LU (2) | LU91889I2 (uk) |
ME (1) | ME00396B (uk) |
MX (1) | MXPA05001684A (uk) |
MY (2) | MY137619A (uk) |
NO (4) | NO333970B1 (uk) |
PE (1) | PE20040897A1 (uk) |
PL (2) | PL216134B1 (uk) |
PT (1) | PT1532149E (uk) |
RS (2) | RS52142B (uk) |
SA (1) | SA03240448B1 (uk) |
SI (1) | SI1532149T1 (uk) |
TW (3) | TWI388325B (uk) |
UA (1) | UA84275C2 (uk) |
UY (1) | UY27946A1 (uk) |
WO (1) | WO2004018468A2 (uk) |
Cited By (2)
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JP2006512311A (ja) * | 2002-11-08 | 2006-04-13 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | キサンチン誘導体、その製法及びその医薬組成物としての使用 |
JP2009079061A (ja) * | 2002-08-21 | 2009-04-16 | Boehringer Ingelheim Pharma Gmbh & Co Kg | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
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AR040232A1 (es) * | 2002-05-31 | 2005-03-23 | Schering Corp | Proceso para preparar inhibidores de la xantina fosfodiesterasa v, y precursores de los mismos |
GB0215293D0 (en) | 2002-07-03 | 2002-08-14 | Rega Foundation | Viral inhibitors |
US7407955B2 (en) | 2002-08-21 | 2008-08-05 | Boehringer Ingelheim Pharma Gmbh & Co., Kg | 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions |
US7569574B2 (en) | 2002-08-22 | 2009-08-04 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Purine derivatives, the preparation thereof and their use as pharmaceutical compositions |
US7495005B2 (en) | 2002-08-22 | 2009-02-24 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, their preparation and their use in pharmaceutical compositions |
US7482337B2 (en) | 2002-11-08 | 2009-01-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
DE10254304A1 (de) * | 2002-11-21 | 2004-06-03 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue Xanthinderivate, deren Herstellung und deren Verwendung als Arzneimittel |
EP1620091B1 (en) | 2003-05-05 | 2010-03-31 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
US7566707B2 (en) | 2003-06-18 | 2009-07-28 | Boehringer Ingelheim International Gmbh | Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions |
DE10355304A1 (de) | 2003-11-27 | 2005-06-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Neue 8-(Piperazin-1-yl)-und 8-([1,4]Diazepan-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel |
AU2004309390B2 (en) | 2003-12-22 | 2011-06-02 | Gilead Sciences, Inc. | Imidazo[4,5-c]pyridine compounds and methods of antiviral treatment |
DE10360835A1 (de) * | 2003-12-23 | 2005-07-21 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische Imidazolverbindungen, deren Herstellung und deren Verwendung als Arzneimittel |
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US7501426B2 (en) | 2004-02-18 | 2009-03-10 | Boehringer Ingelheim International Gmbh | 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions |
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US7393847B2 (en) | 2004-03-13 | 2008-07-01 | Boehringer Ingleheim International Gmbh | Imidazopyridazinediones, their preparation and their use as pharmaceutical compositions |
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US7439370B2 (en) | 2004-05-10 | 2008-10-21 | Boehringer Ingelheim International Gmbh | Imidazole derivatives, their preparation and their use as intermediates for the preparation of pharmaceutical compositions and pesticides |
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CN114989147B (zh) * | 2022-06-20 | 2024-05-17 | 广东晨康生物科技有限公司 | 一种苯并嘧啶类化合物或其药学上可接受的盐及其制备方法和应用 |
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JP2009079061A (ja) * | 2002-08-21 | 2009-04-16 | Boehringer Ingelheim Pharma Gmbh & Co Kg | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
JP2012162555A (ja) * | 2002-08-21 | 2012-08-30 | Boehringer Ingelheim Pharma Gmbh & Co Kg | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
JP2014177485A (ja) * | 2002-08-21 | 2014-09-25 | Boehringer Ingelheim Pharma Gmbh & Co Kg | 8−[3−アミノ−ピペリジン−1−イル]−キサンチン、その製造およびその薬理組成物としての使用 |
JP2016199572A (ja) * | 2002-08-21 | 2016-12-01 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | 1−[([1,5]ナフチリジン−2−イル)メチル]−3−メチル−7−(2−ブチン−1−イル)−8−((r)−3−アミノ−ピペリジン−1−イル)−キサンチン、又はその塩 |
JP2006512311A (ja) * | 2002-11-08 | 2006-04-13 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | キサンチン誘導体、その製法及びその医薬組成物としての使用 |
JP2011012085A (ja) * | 2002-11-08 | 2011-01-20 | Boehringer Ingelheim Pharma Gmbh & Co Kg | キサンチン誘導体、その製法及びその医薬組成物としての使用 |
JP4832758B2 (ja) * | 2002-11-08 | 2011-12-07 | ベーリンガー インゲルハイム ファルマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | キサンチン誘導体、その製法及びその医薬組成物としての使用 |
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