JP2017023813A - 自動式注射装置 - Google Patents
自動式注射装置 Download PDFInfo
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- JP2017023813A JP2017023813A JP2016214237A JP2016214237A JP2017023813A JP 2017023813 A JP2017023813 A JP 2017023813A JP 2016214237 A JP2016214237 A JP 2016214237A JP 2016214237 A JP2016214237 A JP 2016214237A JP 2017023813 A JP2017023813 A JP 2017023813A
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- needle
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Abstract
Description
(i)米国特許出願公開第2006/0040358号明細書(2006年2月23日公開)、米国特許出願公開第2005/0008642号明細書(2005年1月13日公開)、米国特許出願公開第2004/0228859号明細書(2004年11月18日公開)。これら抗体は、限定されないが、例えば、抗体1A(DSMZ寄託番号DSMACC2586)、抗体8(DSMZ寄託番号DSMACC2589)、抗体23(DSMZ寄託番号DSMACC2588)及び上記公報に記載されたような抗体18を含む。
(ii)国際公開第06/138729号(2006年12月28日公開)、国際公開第05/0169709号(2005年2月24日公開)、及びLuなどの2004, J Biol. Chem. 279: 2856 - 65。これら抗体は、限定されないが、上記文献に記載されたような抗体2F8、A12及びIMC−A12を含む。
(iii)国際公開第07/012614号(2007年2月1日公開)、国際公開第07/000328号(2007年1月4日公開)、国際公開第06/013472号(2006年2月9日公開)、国際公開第05/058967号(2005年6月30日公開)及び国際公開第03/059951号(2003年7月24日公開)。
(iv)米国特許出願公開第2005/0084906号明細書(2005年4月21日公開)。これら抗体は、限定されないが、公報に記載されているように、抗体7C10、キメラ抗体C7C10、抗体h7C10、抗体7H2M、キメラ抗体*7C10、抗体GM607、ヒト化抗体7C10バージョン1、ヒト化抗体7C10バージョン2、ヒト化抗体7C10バージョン3、及び、抗体7H2HMを含む。
(v)米国特許出願公開第2005/0249728(2005年11月10日公開)、米国特許出願公開第2005/0186203(2005年8月25日公開)、米国特許出願公開第2004/0265307(2004年12月30日公開)、及び、米国特許出願公開第2003/0235582(2003年12月25日公開)、並びにMaloney等の2003, Cancer Res. 63: 5073 - 83。これら抗体は、文献に記載されているように、限定されないが、抗体EM164、表面再構成されたEM164、ヒト化EM164、huEM164バージョン1.0、huEM164バージョン1.1、huEM164バージョン1.2、及び、huEM164バージョン1.3、を含む。
(vi)米国特許第7037498(2006年5月2日発行)、米国特許出願公開第2005/0244408号明細書(2005年11月30日公開)、米国特許出願公開第2004/0086503号明細書(2004年5月6日)、及び、Cohen等のClinicalCancerRes.11:2063-73、例えば、抗体CP−751、871。これら抗体は、文献に記載されているように、限定されないが、ATCC寄託番号PTA−2792、PTA−2788、PTA−2790、PTA−2791、PTA−2789、PTA−2793を有するハイブリドーマにより生成された抗体、並びに、抗体2.12.1、2.13.2、2.14.3、3.1.1、4.9.2及び4.17.3、のいずれかを含む。
(vii)米国特許出願公開第2005/0136063号明細書(2005年6月23日公開)及び米国特許出願公開第2004/0018191号明細書(2004年1月29日公開)。これら抗体は、公報に記載されているように、限定されないが、抗体19D12と、ATCCの下の番号PTA−5214で寄託されたプラスミド15H12/19D12HCA(γ4)におけるポリヌクレオチドによってコード化された重鎖及びATCCの下の番号PTA−5220で寄託されたプラスミド15H12/19D12LCF(κ)におけるポリヌクレオチドによってコード化された軽鎖を含む抗体と、を含む。
(vii)米国特許出願公開第2004/0202655号明細書(2004年10月14日)。これら抗体は、公報に記載されているように、限定されないが、抗体PINT−6A1、PINT−7A2、PINT−7A4、PINT−7A5、PINT−7A6、PINT−8A1、PINT−9A2、PINT−11A1、PINT−11A2、PINT−11A3、PINT−11A4、PINT−11A5、PINT−11A7、PINT−11A12、PINT−12A1、PINT−12A2、PINT−12A3、PINT−12A4、及びPINT−12A5を含む。
これらそれぞれ及びこれらすべては、その全体を、特にIGF−1受容体を標的とする上記抗体、ペプチボディ及び関連タンパク質などに関して、参考として本願に組み込まれる。
33(抗IFNAR);抗CD38mAb(HuMaxCD38);抗CD40LmAb;抗CriptomAb;抗CTGF特発性肺線維症フェーズIフィブリノゲン(FG−3019);抗CTLA4mAb;抗eotaxin1mAb(CAT−213);抗FGF8mAb;抗ガングリオシドGD2mAb;抗ガングリオシドGM2mAb;抗GDF−8ヒトmAb(MYO−029);抗GM−CSF受容体mAb(CAM−3001);抗HepCmAb(HuMaxHepC);抗IFNαmAb(MEDI−545,MDX−1103);抗IGF1RmAb;抗IGF−1RmAb(HuMax−Inflam);抗IL12mAb(ABT−874);抗IL12/IL23mAb(CNTO1275);抗IL13mAb(CAT−354);抗IL2RamAb(HuMax−TAC);抗IL5受容体mAb;抗インテグリン受容体mAb(MDX−018,CNTO95);抗IP10潰瘍性大腸炎mAb(MDX−1100);抗LLY抗体;BMS−66513;抗マンノース受容体/hCGβmAb(MDX−1307);抗メソテリンdsFv−PE38接合体(CAT−5001);抗PD1mAb(MDX−1106(ONO−4538));抗PDGFRα抗体(IMC−3G3);抗TGFβmAb(GC−1008);抗ヒトTRAIL受容体−2mAb(HGS−ETR2);抗TWEAKmAb;抗VEGFR/Flt−1mAb;抗ZP3mAb(HuMax−ZP3);NVS抗体♯1;及び、NVS抗体♯2、である。
A)、アルファ−フェトタンパク質(AFP)、腫瘍壊死因子(TNF)、CTLA−4(細胞傷害性のT細胞関連抗原である)、Fc−γ−1受容体、HLA−DR10ベータ、HLA−DA抗原、L−セレクチン、呼吸系発疹ウイルス、ヒト免疫不全ウイルス(HIV)、B型肝炎ウイルス(HBV)、ミュータンス連鎖球菌、並びに、黄色ブドウ球菌、である。
Claims (33)
- 治療薬を注射するための装置であって、
前記治療薬を収容するシリンジを隠すカセットと、
自動注射器と、
を備え、
前記自動注射器が、針挿入薬押出駆動手段と、
ドアであって、開口位置において前記カセットを当該ドア内に挿入することを可能とし、閉鎖位置において前記カセットを前記挿入押出駆動手段と位置合わせさせる、ドアと、
を備えることを特徴とする装置。 - 前記カセットが、前記カセットの前記ドア内への正確な方向での挿入を補助する機械構造体を有することを特徴とする請求項1に記載の装置。
- 前記カセットが、前記カセットの前記ドア内への正確な方向での挿入を補助するための表示を有することを特徴とする請求項1または2に記載の装置。
- 前記カセットドアが、前記カセットのための挿入入口点を表示するための表示を有することを特徴とする請求項1から3のいずれか1項に記載の装置。
- シリンジ内に収容された治療薬を注射するための自動注射器であって、
前記シリンジが、カセット内に隠されており、
モータ駆動式針挿入治療薬押出駆動手段と、
ドアであって、開口位置において前記カセットを当該ドア内に挿入することを可能とし、閉鎖位置において前記カセットを前記挿入押出駆動手段と位置合わせさせる、ドアと、
を備えることを特徴とする自動注射器。 - 前記カセットドアが、前記カセットのための挿入入口点を表示するための表示を有することを特徴とする請求項5に記載の自動注射器。
- 前記モータ駆動式駆動手段が、挿入駆動モータと、ラックと、前記挿入駆動モータの回転運動を前記ラックに伝達させる挿入駆動ギアトレインと、を備える針挿入駆動部を有することを特徴とする請求項5または6に記載の自動注射器。
- 前記ギアトレインが、複数のギアを有することを特徴とする請求項7に記載の自動注射器。
- 前記ラックが、間隔をあけた第1及び第2突出部と、前記ギアトレインに係合するラック歯部と、を有することを特徴とする請求項7に記載の自動注射器。
- 針挿入サイクル中において、前記ラックの前記第1突出部が、前記カセット内で前記シリンダを担持する内側スリーブとラッチ解除し、前記内側スリーブを前記カセット内で前方に駆動させ、
針後退サイクル中において、前記ラックの前記第2突出部が、前記内側スリーブに係合して前記内側スリーブを前記カセット内で後方に引っ張ることを特徴とする請求項9に記載の自動注射器。 - 前記モータ駆動式駆動手段が、押出駆動モータと、プランジャロッドと、リードネジと、押出駆動ギアトレインと、を備える治療薬駆動押出駆動部を備え、
前記プランジャロッドが、前記リードネジ及び前記押出駆動ギアトレインを介して前記押出駆動モータによって駆動されることを特徴とする請求項5または6に記載の自動注射器。 - 前記プランジャロッドが、プッシャを有し、
前記リードネジが、螺合式ナットを有し、
前記ナットが、前記プランジャロッドを前記リードネジに結合し、
前記ナットが、前記プランジャロッドの前記プッシャを固定して保持していることを特徴とする請求項11に記載の自動注射器。 - 前記押出駆動ギアトレインが、前記押出駆動モータ及び前記リードネジに各別に結合された複数のギアを有し、これにより、前記押出駆動ギアトレインが前記押出駆動モータの回転運動を伝達させて前記リードネジを駆動させることを可能としていることを特徴とする請求項11に記載の自動注射器。
- 薬物押出サイクル中において、前記押出駆動モータが、前記リードネジを第1方向に回転させ、前記リードネジが、前記ナットを当該リードネジに沿って前方に移動させ、前記プランジャロッドを前記カセット内へ前方に駆動させ、前記シリンジを駆動させて前記治療薬を前記シリンジから放出させ、その後、前記薬物押出駆動モータが、前記リードネジを第2方向に回転させ、前記リードネジが、前記ナットを当該リードネジに沿って後方に移動させ、前記プランジャロッドを前記シリンジ及び前記カセットから引き抜くことを特徴とする請求項12に記載の自動注射器。
- 前記モータ駆動式針挿入治療薬押出駆動手段を制御して監視するためのマイクロプロセッサをさらに備え、これにより、針挿入、薬物押出及び針後退を自動化させていることを特徴とする請求項5に記載の自動注射器。
- 自動注射器と共に使用するためのカセットであって、
治療薬を収容するシリンジであって、当該シリンジの使用前後において当該カセット内に隠される、シリンジと、
当該カセットの前記自動注射器のドア内への正確な方向での挿入を補助する機械構造体と、
を備えることを特徴とするカセット。 - 当該カセットの前記ドア内への正確な方向での挿入を補助するための表示をさらに備えることを特徴とする請求項16に記載のカセット。
- 当該カセットを前記自動注射器内に設置したときに前記自動注射器の窓部と位置合わせされる両側の窓部をさらに備えることを特徴とする請求項16または17に記載のカセット。
- 当該カセット内での前記シリンジの進行を制限する硬質停止部をさらに備え、これにより、所望のあらかじめ設定した設計までの針侵入深さを確実にすることを特徴とする請求項16から18のいずれか1項に記載のカセット。
- シリンジ内に収容された治療薬を注射するための自動注射器であって、
前記シリンジが、カセット内で隠されており、
細長いハンドルセクションと、細長い前記ハンドルセクションに沿うカセット受容セクションと、を備えるケーシングを備え、
細長い前記ハンドルセクションが、軟質把持領域を有することを特徴とする自動注射器。 - 前記ケーシングの細長い前記ハンドルセクションの自由端部が、注射開始ボタンを有し、
前記注射開始ボタンが、親指を当該ボタン上に置くことを最適化するための凹凸部を有することを特徴とする請求項20に記載の自動注射器。 - 前記ケーシングの細長い前記ハンドルセクションの前記自由端部が、当該ケーシングの長手方向軸に対して傾けられており、親指を前記ボタン上に置くことをさらに最適化していることを特徴とする請求項21に記載の自動注射器。
- 前記注射開始ボタンが、当該自動注射器のオペレータまたはユーザに視覚信号を提供するために選択的に照明されており、前記視覚信号が、あらかじめ設定した動作事象を表示させることを特徴とする請求項21または22に記載の自動注射器。
- 前記軟質把持部分が、前記ケーシングの細長い前記ハンドルセクションの後側にあることを特徴とする請求項20から23のいずれか1項に記載の自動注射器。
- 前記ケーシングの前記カセット受容セクションが、当該カセット受容セクションの両側にある窓部と、前記カセットを当該自動注射器内に設置するためのカセットドアと、を有し、
前記カセット受容セクションの前記窓部が、前記カセットを当該自動注射器内に設置したときに前記カセットの窓部と位置合わせされることを特徴とする請求項20から24のいずれか1項に記載の自動注射器。 - 前記カセット窓部と前記カセット内に配置された前記シリンジとを照明するために前記ケーシング内に配置された発光部をさらに備え、オペレータまたはユーザが当該自動注射器の前記カセット及び前記ケーシングの前記窓部を通して注射サイクルを観測することを可能とすることを特徴とする請求項25に記載の自動注射器。
- シリンジ内に収容された治療薬を注射するための自動注射器であって、
前記シリンジが、カセット内に隠されており、
ハンドルセクションと、前記ハンドルセクションに沿うカセット受容セクションと、を有するケーシングを備え、
前記カセット受容セクションが、当該自動注射器を支持面で位置付けるためのベースを形成する平坦な端壁部を画成することを特徴とする自動注射器。 - 前記シリンジが、注射針と、前記注射針を被覆する針シールドと、を有し、
前記カセットが、前記注射針を被覆する前記針シールドを取り外すための針シールド取外器を有し、
前記端壁部が、前記カセットを当該自動注射器内に設置したときに前記針シールド取外器を前記カセットから取り外すことを可能とするアパーチャを有し、これにより、前記注射針を被覆する前記針シールドを取り外すことを特徴とする請求項27に記載の自動注射器。 - 前記端壁部の一部が、前記ケーシングの前記カセット受容セクションのカセットドアによって形成されており、
前記カセットドアが、前記カセットを当該自動注射器内に設置するためのものであり、
前記カセットドアが、前記カセットを当該自動注射器内に設置したときに前記針シールド取外器を前記カセットから取り外すことを可能とする前記アパーチャを有することを特徴とする請求項28に記載の自動注射器。 - 前記端壁部が、前記シールド取外器を前記カセットから取り外すときに照明する標的ライトをさらに有し、注射場所を視覚化して選択するときにオペレータまたはユーザを補助することを特徴とする請求項29に記載の自動注射器。
- 前記端壁部が皮膚に触れるまたは接触するか判断するための皮膚センサをさらに有し、皮膚接触を検出すると、音声の及び視覚のうちの少なくとも一方を表示することを特徴とする請求項27から30のいずれか1項に記載の自動注射器。
- 前記皮膚センサが、容量ベースのセンサであることを特徴とする請求項31に記載の自動注射器。
- 前記皮膚センサが、前記端壁部内に埋め込まれた2つの電極を有し、
前記電極が、皮膚接触を形成したか判断するためにマイクロプロセッサによって使用される容量信号を発生させることを特徴とする請求項32に記載の自動注射器。
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2020138475A1 (ja) * | 2018-12-27 | 2020-07-02 | 株式会社ダイセル | 無針注射器 |
US10786629B2 (en) | 2013-03-15 | 2020-09-29 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
US10792426B2 (en) | 2008-05-20 | 2020-10-06 | Avant Medical Corp. | Autoinjector system |
USD898908S1 (en) | 2012-04-20 | 2020-10-13 | Amgen Inc. | Pharmaceutical product cassette for an injection device |
US10918805B2 (en) | 2011-04-20 | 2021-02-16 | Amgen Inc. | Autoinjector apparatus |
US11724032B2 (en) | 2008-07-23 | 2023-08-15 | Avant Medical Corp. | System and method for an injection using a syringe needle |
Families Citing this family (95)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080311078A1 (en) | 2005-06-14 | 2008-12-18 | Gokarn Yatin R | Self-Buffering Protein Formulations |
CA2711886C (en) | 2008-01-11 | 2016-02-16 | Darrell P. Morgan | Systems and methods for administering medication |
US8177749B2 (en) | 2008-05-20 | 2012-05-15 | Avant Medical Corp. | Cassette for a hidden injection needle |
US9393369B2 (en) | 2008-09-15 | 2016-07-19 | Medimop Medical Projects Ltd. | Stabilized pen injector |
US9427529B2 (en) | 2008-09-15 | 2016-08-30 | Medimop Medical Projects Ltd. | Safeguard mechanism for autoinjector needle |
EP2714157B1 (en) | 2011-06-02 | 2016-08-10 | UCB Biopharma SPRL | Auto-injector |
AR087305A1 (es) * | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
US10485869B2 (en) | 2011-10-18 | 2019-11-26 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with meglumine |
ES2959510T3 (es) | 2011-10-21 | 2024-02-26 | Icu Medical Inc | Sistema de actualización de dispositivos médicos |
CA2878194C (en) * | 2012-07-05 | 2021-06-22 | Unitract Syringe Pty Ltd | Automatic injectors for injectable cartridges and drive control mechanisms therefor |
WO2014020001A1 (en) | 2012-07-30 | 2014-02-06 | Ucb Pharma S.A. | Auto-injector |
WO2014019999A1 (en) | 2012-07-30 | 2014-02-06 | Ucb Pharma S.A. | Auto-injector |
WO2014020000A1 (en) | 2012-07-30 | 2014-02-06 | Ucb Pharma S.A. | Auto-injector |
EP2879735B1 (en) | 2012-07-30 | 2019-11-20 | UCB Biopharma SPRL | Auto-injector |
ES2659491T3 (es) | 2012-09-05 | 2018-03-15 | E3D Agricultural Cooperative Association Ltd. | Dispositivo de autoinyección electrónico |
GB201218913D0 (en) * | 2012-10-22 | 2012-12-05 | Ucb Pharma Sa | Auto-injector and drive unit therefor |
GB2523512A (en) | 2012-12-27 | 2015-08-26 | Kaleo Inc | Devices, systems and methods for locating and interacting with medicament delivery systems |
AU2014206985B2 (en) * | 2013-01-16 | 2018-07-12 | Bayer Pharma Aktiengesellschaft | Lock for drug injection device |
US8652100B1 (en) * | 2013-03-08 | 2014-02-18 | Teva Pharmaceutical Industries, Ltd. | Re-useable injector device for syringe |
KR101738889B1 (ko) | 2013-03-08 | 2017-05-23 | 테바 파마슈티컬 인더스트리즈 리미티드 | 주사기용 재사용 가능한 주입기 장치 |
JP6073507B2 (ja) * | 2013-03-08 | 2017-02-01 | テバ ファーマシューティカル インダストリーズ リミティド | 注射器用の再使用可能な注入器装置 |
EP2968760B1 (en) * | 2013-03-15 | 2024-01-03 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
GB201313888D0 (en) * | 2013-08-02 | 2013-09-18 | Consort Medical Plc | Assembly for an autoinjector device |
GB201314381D0 (en) | 2013-08-12 | 2013-09-25 | Ucb Pharma Sa | Injector |
EP3038683B1 (en) | 2013-08-29 | 2018-07-18 | Sanofi | Safety device for a medicament container |
ES2706738T3 (es) * | 2013-08-29 | 2019-04-01 | Sanofi Sa | Capuchón para un recipiente de medicamentos |
US20150066531A1 (en) | 2013-08-30 | 2015-03-05 | James D. Jacobson | System and method of monitoring and managing a remote infusion regimen |
CN105592877B (zh) * | 2013-09-30 | 2019-06-28 | 麦迪麦珀医疗工程有限公司 | 用于自动注射器的针头退回机构 |
PL3060275T3 (pl) * | 2013-10-24 | 2019-12-31 | Amgen Inc. | Wstrzykiwacz i sposób montażu |
GB2519974B (en) * | 2013-11-01 | 2017-06-14 | Consort Medical Plc | Medicament delivery device sub-assembly |
WO2015110532A1 (en) | 2014-01-27 | 2015-07-30 | Ucb Biopharma Sprl | Auto-injector |
EP3099350B1 (en) * | 2014-01-27 | 2019-06-12 | UCB Biopharma SPRL | Auto-injector |
EP3099351B1 (en) | 2014-01-27 | 2019-11-06 | UCB Biopharma SPRL | Auto-injector |
FR3017956B1 (fr) * | 2014-02-21 | 2018-02-09 | Horiba Jobin Yvon Sas | Systeme et procede de transfert d'un echantillon fluidique dans une cellule fluidique |
IL281354B2 (en) | 2014-06-03 | 2024-06-01 | Amgen Inc | Devices and methods to assist the user of a drug delivery device |
CA2952167C (en) | 2014-06-13 | 2023-06-13 | Aterica Inc. | System and device for management of medication delivery devices |
US9724470B2 (en) | 2014-06-16 | 2017-08-08 | Icu Medical, Inc. | System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy |
EP3185934B1 (en) * | 2014-08-28 | 2018-06-20 | UNL Holdings LLC | Skin sensors for drug delivery devices |
EP3185933B1 (en) | 2014-08-28 | 2020-08-19 | UNL Holdings LLC | Sensor systems for drug delivery devices |
US9539383B2 (en) | 2014-09-15 | 2017-01-10 | Hospira, Inc. | System and method that matches delayed infusion auto-programs with manually entered infusion programs and analyzes differences therein |
GB201416985D0 (en) | 2014-09-26 | 2014-11-12 | Ucb Biopharma Sprl And Bespak Europ Ltd | Housing part for an auto-injector |
US10293120B2 (en) * | 2015-04-10 | 2019-05-21 | West Pharma. Services IL, Ltd. | Redundant injection device status indication |
US11160929B2 (en) | 2015-06-26 | 2021-11-02 | Quio Technologies Llc | Auto-injector device with interchangeable modules for dimensional and operational compatibility with a variety of diverse pre-filled cartridges |
EA201890519A1 (ru) | 2015-08-18 | 2018-07-31 | Ридженерон Фармасьютикалз, Инк. | Ингибирующие антитела против pcsk9 для лечения пациентов с гиперлипидемией, подвергающихся аферезу липопротеинов |
US20170136144A1 (en) | 2015-11-12 | 2017-05-18 | John C. Herr | Compositions and methods for vas-occlusive contraception |
KR102181488B1 (ko) * | 2015-12-08 | 2020-11-23 | 벡톤 디킨슨 프랑스 | 의료용 주입기용 t자 형상의 캡 |
US10300216B2 (en) | 2015-12-08 | 2019-05-28 | Becton Dickinson France S.A.S. | Cap with hemisphere portion for medical injector |
WO2017098438A1 (en) | 2015-12-08 | 2017-06-15 | Becton Dickinson France S.A.S. | Cap for medical injector |
US10737036B2 (en) | 2015-12-08 | 2020-08-11 | Becton Dickinson France S.A.S. | Housing and cap for medical injector |
JP7082568B2 (ja) * | 2015-12-09 | 2022-06-08 | アムジエン・インコーポレーテツド | 信号伝達キャップ付き自動注射器 |
EP3395385A4 (en) | 2015-12-24 | 2019-05-08 | PHC Holdings Corporation | DRUG INFUSION DEVICE, CARTRIDGE ADAPTER, AND DRUG INFUSION SYSTEM |
US10894129B2 (en) * | 2015-12-24 | 2021-01-19 | Phc Holdings Corporation | Drug injection device, cartridge adapter, and drug injection system |
EP3397321B1 (en) * | 2015-12-30 | 2022-10-05 | Ascendis Pharma A/S | Auto injector with temperature control |
NZ742538A (en) | 2015-12-30 | 2023-06-30 | Ascendis Pharma As | Auto injector with adaptable air-shot mechanism |
WO2017114912A1 (en) | 2015-12-30 | 2017-07-06 | Ascendis Pharma A/S | Auto injector with charger safety |
JP7335072B2 (ja) | 2015-12-30 | 2023-08-29 | アセンディス ファーマ エー/エス | 使用済みカートリッジの検出を備える自動注射器および関連の方法 |
AU2016383021B2 (en) | 2015-12-30 | 2021-04-29 | Ascendis Pharma A/S | Auto injector with cartridge locking system |
ES2814287T3 (es) * | 2016-03-15 | 2021-03-26 | Amgen Inc | Reducir la probabilidad de rotura de cristal en dispositivos de administración de fármaco |
WO2017176928A1 (en) * | 2016-04-08 | 2017-10-12 | Icu Medical, Inc. | Control of a drug infusion device |
GB2565978B (en) * | 2016-06-06 | 2022-03-02 | E3D Agricultural Cooporative Association Ltd | Multiple use computerized injector |
CH712753A2 (de) | 2016-07-28 | 2018-01-31 | Tecpharma Licensing Ag | Trennen einer Nadelschutzkappe von einem Produktbehälter und Verfahren zum Montieren einer Injektionsvorrichtung. |
MX2019004580A (es) | 2016-10-21 | 2019-08-12 | Amgen Inc | Formulaciones farmaceuticas y metodos para prepararlas. |
EP3544658B1 (en) | 2016-11-22 | 2024-07-03 | LTS Device Technologies Ltd | Apparatus for delivering a therapeutic substance |
AU2017379094B2 (en) * | 2016-12-23 | 2023-08-24 | Kaleo, Inc. | Medicament delivery device and methods for delivering drugs to infants and children |
EP3570906A4 (en) | 2017-01-17 | 2020-10-21 | Kaleo, Inc. | WIRELESS CONNECTIVITY AND EVENT DETECTION DRUG DELIVERY DEVICES |
KR102110292B1 (ko) * | 2017-01-20 | 2020-05-14 | 엘.쥐.피. 테크노로지 홀딩스 엘엘씨 | 자동 주사기 장치 |
AU2018233465A1 (en) * | 2017-03-16 | 2019-08-15 | Novartis Ag | Injector device |
JP7146816B2 (ja) | 2017-05-23 | 2022-10-04 | アセンディス ファーマ エー/エス | 可変プランジャ力を備えた自動注射器 |
WO2018222521A1 (en) | 2017-05-30 | 2018-12-06 | West Pharma. Services IL, Ltd. | Modular drive train for wearable injector |
MX2019014525A (es) | 2017-06-08 | 2020-02-10 | Becton Dickinson Co | Dispositivo de separacion de liquidos biologicos. |
KR20240001266A (ko) | 2017-06-29 | 2024-01-03 | 아센디스 파마 에이에스 | 재구성 처리 지원을 갖춘 자동 인젝터 |
GB201718315D0 (en) * | 2017-11-06 | 2017-12-20 | Owen Mumford Ltd | Auto-injector |
AU2018368338A1 (en) | 2017-11-16 | 2020-04-09 | Amgen Inc. | Autoinjector with stall and end point detection |
WO2019213187A1 (en) * | 2018-05-01 | 2019-11-07 | Portal Instruments, Inc. | Active injection guide |
US11929160B2 (en) | 2018-07-16 | 2024-03-12 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and compliance detection |
ES2962660T3 (es) | 2018-07-17 | 2024-03-20 | Icu Medical Inc | Sistemas y métodos para facilitar la mensajería clínica en un entorno de red |
AU2019306490A1 (en) | 2018-07-17 | 2021-02-04 | Icu Medical, Inc. | Updating infusion pump drug libraries and operational software in a networked environment |
EP3744368A1 (en) | 2018-10-05 | 2020-12-02 | Sorrel Medical Ltd. | Triggering sequence |
EP3880273A4 (en) | 2018-11-13 | 2022-08-24 | Contraline, Inc. | BIOMATERIALS DELIVERY SYSTEMS AND METHODS |
CA3131538A1 (en) * | 2019-04-17 | 2020-10-22 | Amgen Inc. | Cassette for an autoinjector and related methods |
US20220362472A1 (en) * | 2019-08-01 | 2022-11-17 | Amgen Inc. | Drug delivery device with temperature measurement and related method |
CA3157193A1 (en) * | 2019-10-08 | 2021-04-15 | Amgen Inc. | Cassette for an autoinjector and related methods |
DE102019220296A1 (de) * | 2019-12-19 | 2021-06-24 | Vetter Pharma-Fertigung GmbH & Co. KG | Injektionseinrichtung zum Injizieren einer pharmazeutischen Substanz, und Injektionsladeteil für eine solche Injektionseinrichtung |
WO2021149591A1 (ja) | 2020-01-23 | 2021-07-29 | Phcホールディングス株式会社 | カセット、薬剤注入装置および薬剤注入システム |
USD948039S1 (en) * | 2020-05-08 | 2022-04-05 | Vitagoods, LLC | Serum pen |
CN113749724A (zh) | 2020-06-03 | 2021-12-07 | 巴德阿克塞斯系统股份有限公司 | 包括感测闭塞器的骨内装置 |
JPWO2022004876A1 (ja) * | 2020-07-02 | 2022-01-06 | ||
CN215839325U (zh) * | 2020-09-09 | 2022-02-18 | 巴德阿克塞斯系统股份有限公司 | 用于骨内进入系统的抽吸设备 |
EP4232124A1 (en) | 2020-10-23 | 2023-08-30 | Eli Lilly and Company | Medication delivery device including disposable and reusable portions |
US20230293101A1 (en) * | 2021-07-16 | 2023-09-21 | Eli Lilly And Company | Methods and systems for selecting an injection site |
KR20240035559A (ko) * | 2021-08-19 | 2024-03-15 | 일라이 릴리 앤드 캄파니 | 일회용 및 재사용가능 부분을 포함하는 치료제 전달 장치 |
WO2023023292A1 (en) * | 2021-08-20 | 2023-02-23 | Eli Lilly And Company | Therapeutic agent delivery device with user input |
CN118201667A (zh) * | 2021-11-01 | 2024-06-14 | 贝克顿·迪金森公司 | 用于药物输送装置的警报指示器 |
EP4108277A1 (en) | 2022-07-22 | 2022-12-28 | Ypsomed AG | Syringe unit for a reusable injection device |
EP4275719A3 (en) | 2023-09-07 | 2024-04-24 | Ypsomed AG | Safety mechanism for an autoinjector |
Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03501216A (ja) * | 1987-09-09 | 1991-03-22 | エピメト クンストシュトッフテヒニク ゲゼルシャフト ミット ベシュレンクテル ハフツング | 変形可能なアンプルを有する注射装置 |
JP2826196B2 (ja) * | 1993-04-02 | 1998-11-18 | エリ リリー アンド カンパニー | 多岐管医薬注射の装置と方法 |
JP2000510021A (ja) * | 1996-10-09 | 2000-08-08 | エクイダイン システムズ インコーポレイティド | ジェット式皮下注射装置 |
WO2009143255A1 (en) * | 2008-05-20 | 2009-11-26 | Avant Medical Corp. | Autoinjector system |
WO2010099850A1 (de) * | 2009-03-03 | 2010-09-10 | Dieter Hölzle Technik-Projekte GmbH | Injektionsvorrichtung mit injektionsvolumeneinstellung |
EP2301611A1 (en) * | 2009-09-25 | 2011-03-30 | Letcat Aktiebolag | Medical delivery device |
JP2014502887A (ja) * | 2010-12-21 | 2014-02-06 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 自動注射器 |
Family Cites Families (660)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6241704B1 (en) * | 1901-11-22 | 2001-06-05 | Sims Deltec, Inc. | Drug pump systems and methods |
US2525398A (en) | 1948-02-02 | 1950-10-10 | Arthur L Collins | Hypodermic syringe holder and guide |
US2565081A (en) | 1948-09-15 | 1951-08-21 | Emma C Maynes | Device for operating hypodermic syringes |
US2701566A (en) | 1950-02-07 | 1955-02-08 | Becton Dickinson Co | Injection apparatus |
US2702547A (en) | 1950-02-27 | 1955-02-22 | Antonina S Glass | Motor-driven medical injection apparatus and cartridges therefor |
GB909898A (en) | 1958-04-17 | 1962-11-07 | Donald Travers Lewis | Improvements in or relating to a device for automatically effecting injections with a hypodermic syringe |
US3051173A (en) | 1960-05-12 | 1962-08-28 | Alvin P Johnson | Veterinary hypodermic syringe |
GB999506A (en) | 1960-11-02 | 1965-07-28 | Engis Ltd | Improvements in syringes for dispensing paste or the like |
US3203269A (en) | 1962-10-22 | 1965-08-31 | Lockheed Aircraft Corp | Telescoping screw sequencing device |
US3297210A (en) | 1964-12-28 | 1967-01-10 | Hewlett Packard Co | Dispensing apparatus |
US3623474A (en) | 1966-07-25 | 1971-11-30 | Medrad Inc | Angiographic injection equipment |
US3720211A (en) | 1971-08-18 | 1973-03-13 | G Kyrias | Automatic injection system |
US3964481A (en) | 1972-04-28 | 1976-06-22 | Albert Joseph Gourlandt | Automatic injection device |
US3859996A (en) | 1973-07-18 | 1975-01-14 | Mizzy Inc | Multi-dose injector |
FR2348709A1 (fr) | 1976-04-23 | 1977-11-18 | Pistor Michel | Procede de traitement mesotherapique et dispositif d'injection,formant micro-injecteur automatique,en comportant application |
US4273122A (en) | 1976-11-12 | 1981-06-16 | Whitney Douglass G | Self contained powered injection system |
FR2390175A2 (fr) | 1977-05-10 | 1978-12-08 | Endoscoptic Sarl | Procede de traitement mesotherapique et dispositif d'injection formant micro-injecteur automatique, en comportant application |
DE2812729A1 (de) * | 1978-03-23 | 1979-09-27 | Michael Becker | Injektionsvorrichtung zur intramuskulaeren einspritzung, vornehmlich von insulin |
US4198975A (en) | 1978-10-06 | 1980-04-22 | Haller J Gilbert | Self-injecting hypodermic syringe device |
DE2929425A1 (de) | 1979-07-20 | 1981-02-12 | Lothar Kling | Vorrichtung fuer injektionsspritzen zur intramuskulaeren und subentanen injektion |
DE8006721U1 (de) | 1980-03-12 | 1981-09-03 | Becker, Michael, 5020 Frechen | Injektionsvorrichtung zur intramuskulaeren einspritzung eines medikamentes, insbesondere von insulin |
US4276879A (en) | 1980-03-14 | 1981-07-07 | Vineland Laboratories, Inc. | Automatic injection apparatus |
US4421107A (en) | 1980-10-15 | 1983-12-20 | Estes Roger Q | Surgical retractor elements and assembly |
SE436687B (sv) | 1981-12-14 | 1985-01-21 | Anders Blomberg | Injektionsanordning |
IL65031A (en) | 1982-02-16 | 1983-07-31 | Abic Ltd | Automatic injection apparatus |
US4465478A (en) | 1982-10-14 | 1984-08-14 | Collagen Corporation | Syringe force amplification device |
US4493704A (en) | 1982-11-29 | 1985-01-15 | Oximetrix, Inc. | Portable fluid infusion apparatus |
US4504263A (en) | 1982-12-22 | 1985-03-12 | Valleylab, Inc. | Flow rate monitor with optical sensing chamber |
US4502488A (en) | 1983-01-13 | 1985-03-05 | Allied Corporation | Injection system |
DE3468173D1 (en) | 1983-09-07 | 1988-02-04 | Disetronic Ag | Portable infusion apparatus |
US4758227A (en) | 1983-09-24 | 1988-07-19 | Morf Inc. | Bird injection system |
NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
KR850004274A (ko) | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
US4685903A (en) | 1984-01-06 | 1987-08-11 | Pacesetter Infusion, Ltd. | External infusion pump apparatus |
US4613328A (en) | 1984-10-22 | 1986-09-23 | Cecil Boyd | Bio-medical injector apparatus |
US4573975A (en) * | 1985-01-04 | 1986-03-04 | Frist Brian S | Protective shield for needle receiver |
FR2581548B1 (fr) | 1985-05-09 | 1990-07-20 | Villette Alain | Dispositif d'injection intraosseuse de produits biocompatibles |
US4689042A (en) | 1985-05-20 | 1987-08-25 | Survival Technology, Inc. | Automatic medicament ingredient mixing and injecting apparatus |
US4838857A (en) | 1985-05-29 | 1989-06-13 | Becton, Dickinson And Company | Medical infusion device |
US4636201A (en) | 1985-11-01 | 1987-01-13 | American Hospital Supply Corporation | Hypodermic syringe having a protective sheath cover |
US4680027A (en) | 1985-12-12 | 1987-07-14 | Injet Medical Products, Inc. | Needleless hypodermic injection device |
FR2592307A1 (fr) | 1985-12-30 | 1987-07-03 | Guez Bernard | Dispositif commande par microprocesseur pour administrer ou prelever des produits ainsi que des micro-courants. |
FR2594341B1 (fr) | 1986-02-14 | 1990-08-10 | Charton Jean Pierre | Appareil injecteur pour la pratique de la mesotherapie |
WO1987007160A1 (en) | 1986-05-29 | 1987-12-03 | Baxter Travenol Laboratories, Inc. | Drug delivery apparatus with piston injection site |
US5180371A (en) | 1986-05-30 | 1993-01-19 | Spintech, Inc. | Hypodermic anesthetic injection apparatus and method |
EP0310629A1 (en) | 1986-08-05 | 1989-04-12 | University of Wales College of Medicine | Proximity detector |
DE3645245C2 (de) | 1986-11-14 | 1994-01-27 | Haselmeier Wilhelm Fa | Injektionsgerät |
US5569190A (en) | 1987-06-08 | 1996-10-29 | D'antonio; Nicholas F. | Hypodermic fluid dispenser |
US5080648A (en) | 1987-06-08 | 1992-01-14 | Antonio Nicholas F D | Hypodermic fluid dispenser |
US6056716A (en) | 1987-06-08 | 2000-05-02 | D'antonio Consultants International Inc. | Hypodermic fluid dispenser |
US4877034A (en) | 1987-06-18 | 1989-10-31 | Smith & Nephew, Inc. | Method and device for detection of tissue infiltration |
FR2622457A1 (fr) | 1987-11-03 | 1989-05-05 | Piccinali Eric | Injecteur mesotherapique a microprocesseur |
US4919596A (en) | 1987-12-04 | 1990-04-24 | Pacesetter Infusion, Ltd. | Fluid delivery control and monitoring apparatus for a medication infusion system |
CH675078A5 (ja) | 1988-01-22 | 1990-08-31 | Nosta Ag | |
US5013299A (en) | 1988-03-04 | 1991-05-07 | Clark William C | Syringe resheathing device |
JPH028157A (ja) | 1988-06-28 | 1990-01-11 | Matsushita Electric Ind Co Ltd | コード巻取装置 |
IL87559A (en) | 1988-08-25 | 1993-06-10 | Amir Avni Carmiel And Menachem | Injection apparatus for veterinary use |
US4902279A (en) | 1988-10-05 | 1990-02-20 | Autoject Systems Inc. | Liquid medicament safety injector |
US4929237A (en) | 1988-11-07 | 1990-05-29 | David Medway | Hypodermic needle protection device |
US5024616A (en) | 1988-11-15 | 1991-06-18 | International Medication Systems, Limited | Disposable sheath for hypodermic cannula used with a syringe |
FR2639234B1 (fr) | 1988-11-21 | 1994-05-06 | Denance Raymond | Dispositif d'injection a usage medical et veterinaire dont la mire stabilisatrice est a usage unique et actionne un moyen faisant office de clapet au niveau de l'aiguille |
US5569236A (en) | 1989-06-16 | 1996-10-29 | Science Incorporated | Fluid delivery apparatus |
US5085641A (en) | 1989-07-17 | 1992-02-04 | Survival Technology, Inc. | Conveniently carried frequent use auto-injector with improved cap structure |
KR100221066B1 (ko) | 1989-10-13 | 1999-10-01 | 스튜어트 엘.왓트 | 에리트로포이에틴 유사체와 그를 포함하는 제약학적 조성물 |
US5856298A (en) | 1989-10-13 | 1999-01-05 | Amgen Inc. | Erythropoietin isoforms |
US5149792A (en) | 1989-12-19 | 1992-09-22 | Amgen Inc. | Platelet-derived growth factor B chain analogs |
US5272064A (en) | 1989-12-19 | 1993-12-21 | Amgen Inc. | DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof |
US4986818A (en) | 1990-03-30 | 1991-01-22 | Becton, Dickinson And Company | Syringe assembly |
US5092843A (en) | 1990-04-12 | 1992-03-03 | Survival Technology, Inc. | Dispersion multichamber auto-injector |
USD334233S (en) | 1990-07-08 | 1993-03-23 | Baxter International Inc. | Cannula hub body with viewing lens |
US5114404A (en) | 1990-07-24 | 1992-05-19 | Paxton Gerald R | Multifunctional retractable needle type general purpose disabling syringe having enhanced safety features and related method of operation |
WO1992006725A1 (en) | 1990-10-12 | 1992-04-30 | Habley Medical Technology Corporation | Disposal module with sleeve for prefilled cartridges |
US5114411A (en) | 1990-11-19 | 1992-05-19 | Habley Medical Technology Corporation | Multi-chamber vial |
US5352196A (en) | 1990-11-19 | 1994-10-04 | Habley Medical Technology Corporation | Mixing vial |
US5354287A (en) | 1991-01-16 | 1994-10-11 | Senetek Plc | Injector for delivering fluid to internal target tissue |
US5098400A (en) | 1991-02-14 | 1992-03-24 | Sherwood Medical Company | Needle shield |
US5451210A (en) | 1991-04-29 | 1995-09-19 | Lifequest Medical, Inc. | System and method for rapid vascular drug delivery |
US5868711A (en) | 1991-04-29 | 1999-02-09 | Board Of Regents, The University Of Texas System | Implantable intraosseous device for rapid vascular access |
US5176643A (en) | 1991-04-29 | 1993-01-05 | George C. Kramer | System and method for rapid vascular drug delivery |
US5300031A (en) | 1991-06-07 | 1994-04-05 | Liebel-Flarsheim Company | Apparatus for injecting fluid into animals and disposable front loadable syringe therefor |
DE59202070D1 (de) | 1991-07-24 | 1995-06-08 | Medico Dev Investment Co | Injektor. |
US5200604A (en) | 1991-08-07 | 1993-04-06 | Laser Engineering, Inc. | Handpiece optical proximity detector for disabling surgical laser beam |
DE69130365T2 (de) | 1991-08-07 | 1999-06-02 | Abbott Lab | Einheit aus sicherheitsspritze und im voraus gefüllte medikamentenbehälter |
US5221268A (en) | 1991-12-06 | 1993-06-22 | Block Medical, Inc. | Multiple dose control apparatus |
CA2127359C (en) | 1992-01-07 | 2006-05-30 | John Glyndwr Wilmot | Automatic injectors |
IL101720A (en) | 1992-04-29 | 1998-09-24 | Mali Tech Ltd | Needle for syringe or the like |
US6290683B1 (en) | 1992-04-29 | 2001-09-18 | Mali-Tech Ltd. | Skin piercing needle assembly |
US5382785A (en) | 1992-05-04 | 1995-01-17 | Diolase Corporation | Laser beam delivery path and target proximity sensor |
US5300041A (en) | 1992-06-01 | 1994-04-05 | Habley Medical Technology Corporation | Dose setting and repeating syringe |
US5269766A (en) | 1992-06-09 | 1993-12-14 | Habley Medical Technology Corporation | Dental syringe having an automatically retractable medication carpule and needle cannula |
FR2693112B1 (fr) | 1992-07-01 | 1994-09-02 | Raymond Denance | Dispositif électromécanique d'injection à usage médical et vétérinaire actionné par une gâchette. |
US5271413A (en) | 1992-07-22 | 1993-12-21 | Dalamagas Photios P | Method to sense the tissue for injection from a hypodermic needle |
GB9219849D0 (en) | 1992-09-19 | 1992-10-28 | Hypoguard Uk Ltd | Device |
AU5132993A (en) | 1992-09-21 | 1994-04-12 | Habley Medical Technology Corporation | Device and method for containing an ampule and transferring liquid within the ampule to a container |
IL107038A (en) | 1992-10-05 | 1997-04-15 | Senetek Plc | Medicament injectors and methods for injection using same |
US5569212A (en) | 1994-07-22 | 1996-10-29 | Raya Systems, Inc. | Apparatus for electrically determining injection doses in syringes |
US5681291A (en) | 1992-11-19 | 1997-10-28 | Tebro S.A. | Disposable auto-injector for prefilled syringes |
FR2701211B1 (fr) | 1993-02-08 | 1995-05-24 | Aguettant Lab | Instrument doseur, notamment d'injection |
ATE173171T1 (de) | 1993-03-23 | 1998-11-15 | Focal Inc | Gerät und methode für den lokalen auftrag von polymermaterial auf gewebe |
US5584815A (en) | 1993-04-02 | 1996-12-17 | Eli Lilly And Company | Multi-cartridge medication injection device |
US5746714A (en) | 1993-04-05 | 1998-05-05 | P.A.T.H. | Air powered needleless hypodermic injector |
US5366118A (en) | 1993-04-30 | 1994-11-22 | Guardian Personal Security Products, Inc. | Dispenser for aerosol device |
GB9309151D0 (en) | 1993-05-04 | 1993-06-16 | Zeneca Ltd | Syringes and syringe pumps |
US5540664A (en) | 1993-05-27 | 1996-07-30 | Washington Biotech Corporation | Reloadable automatic or manual emergency injection system |
US5425715A (en) | 1993-08-05 | 1995-06-20 | Survival Technology, Inc. | Reloadable injector |
ZA946122B (en) | 1993-08-17 | 1995-03-20 | Amgen Inc | Erythropoietin analogs |
US5431627A (en) | 1993-11-12 | 1995-07-11 | Abbott Laboratories | Cassette identification system for use with a multi-program drug infusion pump |
US5830851A (en) | 1993-11-19 | 1998-11-03 | Affymax Technologies N.V. | Methods of administering peptides that bind to the erythropoietin receptor |
US5773569A (en) | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
US5531697A (en) * | 1994-04-15 | 1996-07-02 | Sims Deltec, Inc. | Systems and methods for cassette identification for drug pumps |
CA2129284C (en) | 1993-11-24 | 1999-03-09 | Kenneth J. Niehoff | Controlling plunger drives for fluid injection in animals |
US5354286A (en) | 1993-12-07 | 1994-10-11 | Survival Technology, Inc. | Injection device having polyparaxylylene coated container |
US5478316A (en) | 1994-02-02 | 1995-12-26 | Becton, Dickinson And Company | Automatic self-injection device |
US5514097A (en) | 1994-02-14 | 1996-05-07 | Genentech, Inc. | Self administered injection pen apparatus and method |
EP0693949B1 (fr) | 1994-02-14 | 1998-05-06 | Sanofi | Module injecteur pour une seringue |
FR2716375B3 (fr) | 1994-02-23 | 1996-05-24 | Alain Villette | Injecteur médical. |
US5536249A (en) | 1994-03-09 | 1996-07-16 | Visionary Medical Products, Inc. | Pen-type injector with a microprocessor and blood characteristic monitor |
AU1990495A (en) | 1994-03-18 | 1995-10-09 | Vitajet Corporation | Air-powered needleless hypodermic injector |
AU1994295A (en) | 1994-05-16 | 1995-12-05 | Washington Biotech Corporation | Modular automatic or manual emergency medicine injection system |
WO1995032749A2 (de) | 1994-05-30 | 1995-12-07 | Medico Development Investment Company | Injektionsgerät |
GB9412301D0 (en) | 1994-06-17 | 1994-08-10 | Safe T Ltd | Hollow-needle drugs etc applicators |
US5885574A (en) | 1994-07-26 | 1999-03-23 | Amgen Inc. | Antibodies which activate an erythropoietin receptor |
AU3272695A (en) | 1994-08-12 | 1996-03-07 | Immunomedics Inc. | Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells |
US5569197A (en) | 1994-12-21 | 1996-10-29 | Schneider (Usa) Inc | Drug delivery guidewire |
US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
US5690618A (en) | 1995-02-22 | 1997-11-25 | Mark Timothy Smith | Electronic syringe |
GB9503969D0 (en) | 1995-02-28 | 1995-04-19 | Sams Bernard | Incrementing mechanism |
US5647853A (en) | 1995-03-03 | 1997-07-15 | Minimed Inc. | Rapid response occlusion detector for a medication infusion pump |
JP4373495B2 (ja) | 1995-03-23 | 2009-11-25 | イミュネックス・コーポレーション | Il−17受容体 |
FR2733155B1 (fr) | 1995-04-18 | 1997-09-19 | Tebro | Auto-injecteur rechargeable |
US6099502A (en) | 1995-04-20 | 2000-08-08 | Acist Medical Systems, Inc. | Dual port syringe |
AU705105B2 (en) | 1995-06-02 | 1999-05-13 | Novo Nordisk A/S | Automatic withdrawal of piston rod |
US5686292A (en) | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
US5767078A (en) | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
CA2151407A1 (en) | 1995-06-09 | 1996-12-10 | Duncan Newman | Injection device |
US5647851A (en) | 1995-06-12 | 1997-07-15 | Pokras; Norman M. | Method and apparatus for vibrating an injection device |
PT902694E (pt) | 1995-08-22 | 2003-09-30 | Mdc Invest Holdings Inc | Ampolas de injeccao pre-cheias dotadas de agulha retractil |
US5779675A (en) * | 1995-08-25 | 1998-07-14 | Medrad, Inc. | Front load pressure jacket system with syringe holder |
DE19536566C1 (de) | 1995-10-02 | 1997-02-06 | Arburg Gmbh & Co | Verfahren zur Regelung des Werkzeuginnendrucks an einer zyklisch arbeitenden Maschine |
US6283951B1 (en) | 1996-10-11 | 2001-09-04 | Transvascular, Inc. | Systems and methods for delivering drugs to selected locations within the body |
JP2001505069A (ja) | 1996-02-29 | 2001-04-17 | メディ―ジェクト コーポレイション | 調整可能なプランジャ移動ギャップを備えたノズル組立体 |
GB9606829D0 (en) | 1996-03-30 | 1996-06-05 | Jeffrey Peter | Supplying materials etc |
ES2121536B1 (es) | 1996-07-15 | 1999-05-16 | Arjona Perez Mariano | Aparato automatico para la aplicacion de inyecciones. |
US5843036A (en) | 1996-08-23 | 1998-12-01 | Becton Dickinson And Company | Non-dosing cartridge for an injection device |
US5709662A (en) | 1996-08-23 | 1998-01-20 | Becton Dickinson France, S.A. | Cartridge for an injection device |
JP2001521409A (ja) | 1996-09-03 | 2001-11-06 | エム ディー シー インベストメント ホールディングス,インコーポレイテッド | 予め充填されている収縮可能な針注射器 |
AU5251198A (en) | 1996-11-15 | 1998-06-03 | Beloit Technologies, Inc. | Dual feed flow system apparatus for a paper web coater |
WO1998028032A1 (en) | 1996-12-20 | 1998-07-02 | Novo Nordisk A/S | Needle insertion mechanism |
US6203530B1 (en) | 1997-01-28 | 2001-03-20 | Pos-T-Vac, Inc. | Auto-injection device |
US6171283B1 (en) | 1997-03-10 | 2001-01-09 | Safety Syringes, Inc. | Disposable self-shielding unit dose syringe guard |
US6159184A (en) | 1997-03-10 | 2000-12-12 | Safety Syringes, Inc. | Disposable self-shielding unit dose syringe guard |
US5928158A (en) | 1997-03-25 | 1999-07-27 | Aristides; Arellano | Medical instrument with nerve sensor |
DE19717107B4 (de) | 1997-04-23 | 2005-06-23 | Disetronic Licensing Ag | System aus Behältnis und Antriebsvorrichtung für einen Kolben, der in dem ein Medikamentfluid enthaltenden Behältnis gehalten ist |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
US5968063A (en) | 1997-05-14 | 1999-10-19 | Jennifer Chu | Intramuscular stimulation therapy facilitating device and method |
US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
US5911703A (en) | 1997-05-22 | 1999-06-15 | Avant Drug Delivery Systems, Inc. | Two-stage fluid medicament jet injector |
CA2296770A1 (en) | 1997-07-14 | 1999-01-28 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
US6569127B1 (en) * | 1997-07-18 | 2003-05-27 | Liebel-Flarsheim Company | Adapter and syringe for front-loading medical fluid injector |
US6391633B1 (en) | 1997-07-23 | 2002-05-21 | Roche Diagnostics Gmbh | Production of erythropoietin by endogenous gene activation |
GB9716065D0 (en) | 1997-07-31 | 1997-10-01 | Owen Mumford Ltd | Improvements relating to injection devices |
US6171276B1 (en) | 1997-08-06 | 2001-01-09 | Pharmacia & Upjohn Ab | Automated delivery device and method for its operation |
US5921966A (en) | 1997-08-11 | 1999-07-13 | Becton Dickinson And Company | Medication delivery pen having an improved clutch assembly |
PT1003580E (pt) | 1997-08-21 | 2004-01-30 | Ares Trading Sa | Aperfeicoamento relativos a dispositivos para injeccoes |
US6149626A (en) | 1997-10-03 | 2000-11-21 | Bachynsky; Nicholas | Automatic injecting syringe apparatus |
US6019747A (en) | 1997-10-21 | 2000-02-01 | I-Flow Corporation | Spring-actuated infusion syringe |
CA2223659A1 (fr) | 1997-12-03 | 1999-06-03 | Alain Villette | Injecteur medical |
AU738058B2 (en) | 1997-12-16 | 2001-09-06 | Meridian Medical Technologies, Inc. | Automatic injector |
ATE269669T1 (de) | 1998-01-12 | 2004-07-15 | Alsensa Aps | Injektionseinheit |
DE29801168U1 (de) | 1998-01-24 | 1999-08-12 | Medico Dev Investment Co | Injektionsgerät |
GB9803084D0 (en) | 1998-02-14 | 1998-04-08 | Owen Mumford Ltd | Improvements relating to medical injection devices |
US6090082A (en) | 1998-02-23 | 2000-07-18 | Becton, Dickinson And Company | Vial retainer interface to a medication delivery pen |
US6030086A (en) | 1998-03-02 | 2000-02-29 | Becton, Dickinson And Company | Flash tube reflector with arc guide |
US6183442B1 (en) | 1998-03-02 | 2001-02-06 | Board Of Regents Of The University Of Texas System | Tissue penetrating device and methods for using same |
US6104941A (en) | 1998-03-26 | 2000-08-15 | Ge Marquette Medical Systems, Inc. | Physiological sensor |
JPH11276583A (ja) | 1998-03-31 | 1999-10-12 | Miyota Kk | 注射器及び注射液充填用カートリッジ |
US6616639B2 (en) * | 1998-04-17 | 2003-09-09 | Becton, Dickinson And Company | Safety shield system for syringes |
US6310078B1 (en) | 1998-04-20 | 2001-10-30 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted amino acids as erythropoietin mimetics |
DE19819409A1 (de) | 1998-04-30 | 1999-11-11 | Schering Ag | Injektionsvorrichtung |
JP3427171B2 (ja) | 1998-05-01 | 2003-07-14 | 日創電機株式会社 | 成形機 |
DE19822031C2 (de) | 1998-05-15 | 2000-03-23 | Disetronic Licensing Ag | Autoinjektionsgerät |
US20050181482A1 (en) | 2004-02-12 | 2005-08-18 | Meade Harry M. | Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk |
EP1087808B1 (en) | 1998-06-15 | 2003-12-03 | Medrad Inc. | Encoding of syringe information |
US6743202B2 (en) | 1998-06-15 | 2004-06-01 | Medrad, Inc. | Encoding of syringe information |
DE69933216T2 (de) | 1998-06-15 | 2007-09-20 | GTC Biotherapeutics, Inc., Framingham | Erythropoietin-analog-menschliches serum-albumin fusionsprotein |
JP2002520097A (ja) | 1998-07-08 | 2002-07-09 | ノボ ノルディスク アクティーゼルスカブ | 薬剤放出装置並びにこれに使用されるカートリッジ集合体 |
US6428528B2 (en) | 1998-08-11 | 2002-08-06 | Antares Pharma, Inc. | Needle assisted jet injector |
GB9817662D0 (en) | 1998-08-13 | 1998-10-07 | Crocker Peter J | Substance delivery |
US5993423A (en) | 1998-08-18 | 1999-11-30 | Choi; Soo Bong | Portable automatic syringe device and injection needle unit thereof |
EP1813624B1 (en) | 1998-10-23 | 2010-08-11 | Amgen Inc. | Methods and compositions for the prevention and treatment of anemia |
TWI250988B (en) | 1998-10-23 | 2006-03-11 | Kirin Amgen Inc | Thrombopoietic compounds |
SE9803662D0 (sv) | 1998-10-26 | 1998-10-26 | Pharmacia & Upjohn Ab | Autoinjector |
US6800071B1 (en) | 1998-10-29 | 2004-10-05 | Medtronic Minimed, Inc. | Fluid reservoir piston |
US6248093B1 (en) | 1998-10-29 | 2001-06-19 | Minimed Inc. | Compact pump drive system |
CA2349382C (en) | 1998-10-30 | 2007-12-11 | Immunex Corporation | Method and apparatus for operating a syringe and vial for injections |
ES2350454T3 (es) | 1998-11-27 | 2011-01-24 | Ucb Pharma S.A. | Composiciones y métodos para incrementar la mineralización de la sustancia ósea. |
US6540672B1 (en) | 1998-12-09 | 2003-04-01 | Novo Nordisk A/S | Medical system and a method of controlling the system for use by a patient for medical self treatment |
US6077055A (en) * | 1998-12-03 | 2000-06-20 | Sims Deltec, Inc. | Pump system including cassette sensor and occlusion sensor |
EP1006184A1 (en) | 1998-12-03 | 2000-06-07 | F. Hoffmann-La Roche Ag | IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof |
US6238335B1 (en) | 1998-12-11 | 2001-05-29 | Enteric Medical Technologies, Inc. | Method for treating gastroesophageal reflux disease and apparatus for use therewith |
US20010018937A1 (en) | 1998-12-28 | 2001-09-06 | Shigeru Nemoto | Method and device for pre-filling a syringe with a contrast agent |
US6645177B1 (en) | 1999-02-09 | 2003-11-11 | Alaris Medical Systems, Inc. | Directly engaged syringe driver system |
JP2000237309A (ja) | 1999-02-25 | 2000-09-05 | Ichiro Takai | インスリン注入経歴把握装置 |
EP1169352A4 (en) | 1999-04-14 | 2005-05-04 | Smithkline Beecham Corp | ANTIBODY AGAINST THE ERYTHROPOIETIN RECEPTOR |
US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
SE9901366D0 (sv) | 1999-04-16 | 1999-04-16 | Pharmacia & Upjohn Ab | Injector device and method for its operation |
SE9901736D0 (sv) | 1999-05-12 | 1999-05-12 | Pharmacia & Upjohn Ab | Injectino device and method for ITS operation |
US6752787B1 (en) | 1999-06-08 | 2004-06-22 | Medtronic Minimed, Inc., | Cost-sensitive application infusion device |
US6270481B1 (en) | 1999-06-16 | 2001-08-07 | Breg, Inc. | Patient-controlled medication delivery system |
AU5774500A (en) | 1999-06-30 | 2001-01-31 | Baxter International Inc. | Syringe for transfer of medication from a prefilled medication container |
CZ299516B6 (cs) | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
EP1200144A1 (en) | 1999-07-30 | 2002-05-02 | Medrad, Inc. | Injector systems and syringe adapters for use therewith |
US6213987B1 (en) * | 1999-08-02 | 2001-04-10 | Michael N. Hirsch | Shroud for a used hypodermic syringe needle |
US6318647B1 (en) | 1999-08-18 | 2001-11-20 | The Procter & Gamble Company | Disposable cartridge for use in a hand-held electrostatic sprayer apparatus |
US6520928B1 (en) | 1999-08-19 | 2003-02-18 | Alceu Meibach Rosa Junior | Medical liquid injection system and method |
JP2003508164A (ja) | 1999-09-07 | 2003-03-04 | コンピューター・コントロールド・シリンジ・インコーポレーテッド | 引っ込み可能な針装置 |
AU7839900A (en) | 1999-09-29 | 2001-04-30 | Sterling Medivations, Inc. | Reusable medication delivery device |
US6569123B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Prefillable intradermal injector |
US20050202538A1 (en) | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
EP1228214A2 (en) | 1999-11-12 | 2002-08-07 | MERCK PATENT GmbH | Erythropoietin forms with improved properties |
US6520930B2 (en) | 1999-11-24 | 2003-02-18 | Medrad, Inc. | Injectors, injector systems and injector control |
ES2287041T3 (es) | 1999-11-24 | 2007-12-16 | Medrad, Inc. | Inyector de carga frontal y jeringa. |
AU1816701A (en) | 1999-12-07 | 2001-06-18 | Medrad, Inc. | Syringes, syringe tubing and fluid transfer systems |
US6652489B2 (en) | 2000-02-07 | 2003-11-25 | Medrad, Inc. | Front-loading medical injector and syringes, syringe interfaces, syringe adapters and syringe plungers for use therewith |
AUPQ599700A0 (en) | 2000-03-03 | 2000-03-23 | Super Internet Site System Pty Ltd | On-line geographical directory |
US6485465B2 (en) | 2000-03-29 | 2002-11-26 | Medtronic Minimed, Inc. | Methods, apparatuses, and uses for infusion pump fluid pressure and force detection |
US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
US6190361B1 (en) | 2000-04-18 | 2001-02-20 | Gettig Technologies, Inc. | Selectively lockable needle guard |
EP1961425B1 (en) | 2000-04-21 | 2017-07-19 | Amgen Inc. | Methods and erythropoeitin analogs for the prevention and treatment of anemia |
US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
GB0012165D0 (en) | 2000-05-20 | 2000-07-12 | Team Consulting Ltd | Portable device with consistent power output |
US6673048B1 (en) | 2000-05-24 | 2004-01-06 | Acist Medical Systems, Inc. | Pressure sleeve assembly |
US6645169B1 (en) | 2000-06-08 | 2003-11-11 | Avant Drug Delivery Systems, Inc. | Air-in-tip jet injector |
US6406456B1 (en) | 2000-06-08 | 2002-06-18 | Avant Drug Delivery Systems, Inc. | Jet injector |
JP2001357132A (ja) | 2000-06-12 | 2001-12-26 | Iwami Kaihatsu Kk | 医薬品の投与システム及び投与方法 |
WO2002007812A2 (en) | 2000-07-20 | 2002-01-31 | Acist Medical Systems, Inc. | Syringe plunger locking mechanism |
JP3794252B2 (ja) | 2000-07-26 | 2006-07-05 | 東芝機械株式会社 | 電動式射出成形機および電動式射出成形機の射出制御方法 |
US6986760B2 (en) | 2000-08-02 | 2006-01-17 | Becton, Dickinson And Company | Pen needle and safety shield system |
DE60126782T2 (de) | 2000-08-10 | 2007-12-06 | Novo Nordisk A/S | Vorrichtung zur verabreichung von medikamenten mit einem halter für eine kassette |
US7078376B1 (en) | 2000-08-11 | 2006-07-18 | Baxter Healthcare S.A. | Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects |
AU2001281753A1 (en) | 2000-08-29 | 2002-03-13 | Novo-Nordisk A/S | Automatic injection device with torsion function for retraction of needle |
JP2004518621A (ja) | 2000-09-08 | 2004-06-24 | グリフォン セラピューティクス,インコーポレーテッド | 「擬似」天然型化学的ライゲーション |
EP1324792A2 (en) | 2000-09-21 | 2003-07-09 | Elan Pharma International Limited | Reconstitution and injection system |
WO2002024257A1 (en) | 2000-09-22 | 2002-03-28 | Novo Nordisk A/S | A medication delivery device |
US6641561B1 (en) | 2000-10-10 | 2003-11-04 | Meridian Medical Technologies, Inc. | Drug delivery device |
US6770052B2 (en) | 2000-10-10 | 2004-08-03 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
US6652483B2 (en) | 2000-11-07 | 2003-11-25 | Avant Drug Delivery Systems, Inc. | Needleless jet injector system with separate drug reservoir |
US6503454B1 (en) | 2000-11-22 | 2003-01-07 | Xerox Corporation | Multi-ejector system for ejecting biofluids |
US7271689B1 (en) | 2000-11-22 | 2007-09-18 | Fonar Corporation | Magnet structure |
WO2002043573A2 (en) | 2000-11-29 | 2002-06-06 | Docusys, Inc. | Drug delivery device incorporating a tracking code |
SE518981C2 (sv) | 2000-12-14 | 2002-12-17 | Shl Medical Ab | Autoinjektor |
DE60144439D1 (de) | 2000-12-20 | 2011-05-26 | Hoffmann La Roche | Konjugate von erythropoietin (epo) mit polyethylenglykol (peg) |
US6387078B1 (en) | 2000-12-21 | 2002-05-14 | Gillespie, Iii Richard D. | Automatic mixing and injecting apparatus |
IT1320868B1 (it) | 2000-12-29 | 2003-12-10 | Cane Srl | Dispositivo portatile per infusione di farmaci. |
WO2002060513A2 (en) | 2001-01-02 | 2002-08-08 | Safety Syringes, Inc. | Systems and method for tracking administration of medical products |
JP2004531217A (ja) | 2001-01-05 | 2004-10-14 | ファイザー・インク | インスリン様成長因子i受容体に対する抗体 |
ATE381360T1 (de) | 2001-02-14 | 2008-01-15 | Novo Nordisk As | Elektronisch gesteuerte injektions- oder infusionsvorrichtung |
JP3845857B2 (ja) | 2001-03-15 | 2006-11-15 | ニプロ株式会社 | 簡易薬液注入器 |
EP1383927B1 (en) | 2001-04-04 | 2009-07-08 | GenOdyssee | New polynucleotides and polypeptides of the erythropoietin gene |
US6817986B2 (en) | 2001-04-13 | 2004-11-16 | Avant Medical Corp. | Jet injector with data logging system for use in compliance and dose monitoring programs |
WO2002083209A1 (en) | 2001-04-13 | 2002-10-24 | Nipro Diabetes Systems | Drive system for an infusion pump |
EP2292655B1 (en) | 2001-05-11 | 2012-03-14 | Amgen SF, LLC | Peptides and related molecules that bind to tall-1 |
EP2258425B1 (en) | 2001-05-16 | 2013-01-30 | Eli Lilly and Company | Medication injector apparatus |
US7308300B2 (en) | 2001-05-30 | 2007-12-11 | Acist Medical Systems, Inc. | Medical injection system |
EP1420693A4 (en) | 2001-06-05 | 2007-05-30 | Barnev Ltd | ANCHORING ELEMENT FOR PROBE |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
DE10129584B4 (de) | 2001-06-20 | 2007-06-28 | Tecpharma Licensing Ag | Auslöseeinrichtung für einen Druckstrahlinjektor |
US7364736B2 (en) | 2001-06-26 | 2008-04-29 | Amgen Inc. | Antibodies to OPGL |
US6416322B2 (en) | 2001-07-03 | 2002-07-09 | Danny W. Qualliotine | Powdering attachment for applying powder to tooth surfaces |
US6835193B2 (en) | 2001-07-10 | 2004-12-28 | Myocardial Therapeutics, Inc. | Methods for controlled depth injections into interior body cavities |
US6796957B2 (en) | 2001-07-10 | 2004-09-28 | Myocardial Therapeutics, Inc. | Sterile aspiration/reinjection systems |
DE60203118T2 (de) | 2001-07-16 | 2006-04-13 | Eli Lilly And Co., Indianapolis | Medikamentenverabreichungsvorrichtung mit durch rotation ausführbarem priming und durch zug-/schubbewegung ausführbarer injektion |
US20030065536A1 (en) | 2001-08-13 | 2003-04-03 | Hansen Henrik Egesborg | Portable device and method of communicating medical data information |
US6900292B2 (en) | 2001-08-17 | 2005-05-31 | Lee-Hwei K. Sun | Fc fusion proteins of human erythropoietin with increased biological activities |
US7247304B2 (en) | 2001-08-23 | 2007-07-24 | Genmab A/S | Methods of treating using anti-IL-15 antibodies |
EA014802B1 (ru) | 2001-08-23 | 2011-02-28 | Генмаб А/С | АНТИТЕЛА К ИНТЕРЛЕЙКИНУ 15 (ВАРИАНТЫ), СПОСОБ ИХ ПОЛУЧЕНИЯ, ИММУНОКОНЪЮГАТ НА ИХ ОСНОВЕ, ГИБРИДОМА, ТРАНСФЕКТОМА, ТРАНСГЕННОЕ ЖИВОТНОЕ, ЭКСПРЕССИОННЫЙ ВЕКТОР (ВАРИАНТЫ) И НУКЛЕИНОВАЯ КИСЛОТА ДЛЯ ИХ ПОЛУЧЕНИЯ, СПОСОБ ЛЕЧЕНИЯ (ВАРИАНТЫ) И СПОСОБ ДИАГНОСТИКИ ЗАБОЛЕВАНИЙ, ОПОСРЕДОВАННЫХ ИЛ-15, СПОСОБ ИНГИБИРОВАНИЯ ИНДУЦИРОВАННОЙ ИЛ-15 ПРОДУКЦИИ TNF-α И СПОСОБ ИНГИБИРОВАНИЯ ИНДУЦИРОВАННОЙ ИЛ-15 ПРОЛИФЕРАЦИИ КЛЕТОК |
US6669664B2 (en) | 2001-09-07 | 2003-12-30 | Avant Drug Delivery Systems, Inc. | Vacuum control cycle for jet injector |
EP1433456A4 (en) | 2001-09-12 | 2007-05-30 | Terumo Corp | MEDICATION CONTAINERS AND MEDICATION INJECTION DEVICE CONTAINING THEM |
US6930086B2 (en) | 2001-09-25 | 2005-08-16 | Hoffmann-La Roche Inc. | Diglycosylated erythropoietin |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
EP1446328B1 (en) | 2001-10-16 | 2017-05-31 | Medical Instill Technologies, Inc. | DISPENSER WITH SEALED CHAMBER AND ONE−WAY VALVE FOR PROVIDING METERED AMOUNTS OF SUBSTANCES |
GB0125604D0 (en) | 2001-10-25 | 2001-12-19 | Glaxo Group Ltd | Novel process |
KR100877302B1 (ko) | 2001-11-09 | 2009-01-07 | 알자 코포레이션 | 접이식 주사기 카트리지 |
CN1315544C (zh) | 2001-11-09 | 2007-05-16 | 阿尔扎公司 | 气动自动注射器 |
US20030105430A1 (en) | 2001-11-30 | 2003-06-05 | Elan Pharma International Limited Wil House | Automatic injector |
GB0129173D0 (en) | 2001-12-06 | 2002-01-23 | Dca Design Int Ltd | Improvements in and relating to a medicament cartridge |
GB0130140D0 (en) | 2001-12-18 | 2002-02-06 | Dca Design Int Ltd | Improvements in and relating to medicament delivery service |
JP2003180828A (ja) | 2001-12-21 | 2003-07-02 | Matsushita Electric Ind Co Ltd | 電動流体吐出装置 |
AU2002351746A1 (en) | 2001-12-21 | 2003-07-15 | Maxygen Aps | Erythropoietin conjugates |
US6648858B2 (en) | 2001-12-21 | 2003-11-18 | Visual Connections, Inc. | Safety device for a sheathed, prefilled injection syringe |
EP1492818B1 (en) * | 2001-12-21 | 2012-08-08 | CellAct Pharma GmbH | Anti-tirc7 antibodies and tnf-alpha antagonists in combination -therapy of inflammatory diseases |
US7241444B2 (en) | 2002-01-18 | 2007-07-10 | Pierre Fabre Medicament | Anti-IGF-IR antibodies and uses thereof |
ES2427964T3 (es) | 2002-01-18 | 2013-11-05 | Pierre Fabre Medicament | Nuevos anticuerpos anti-IGF-IR y sus aplicaciones |
JP2003220142A (ja) | 2002-01-30 | 2003-08-05 | Yoshino Kogyosho Co Ltd | 注射器 |
WO2003064664A1 (en) | 2002-01-31 | 2003-08-07 | Oxford Biomedica (Uk) Limited | Physiologically regulated erythropoietin- exprressing vector for the treatment of anaemia |
GB0202252D0 (en) | 2002-01-31 | 2002-03-20 | Oxford Biomedica Ltd | Anemia |
US6828908B2 (en) | 2002-02-06 | 2004-12-07 | Ronald Scott Clark | Locator system with an implanted transponder having an organically-rechargeable battery |
AUPS135702A0 (en) | 2002-03-25 | 2002-05-09 | Occupational & Medical Innovations Ltd | A medical syringe container |
AU2002247896A1 (en) | 2002-03-26 | 2003-10-08 | Lek Pharmaceutical And Chemical Company D.D. | Process for the preparation of a desired erythropoietin glyco-isoform profile |
AU2003222069A1 (en) | 2002-03-29 | 2003-10-20 | Centocor, Inc. | Mammalian cdr mimetibodies, compositions, methods and uses |
USD483116S1 (en) | 2002-04-05 | 2003-12-02 | Penjet Corporation | Needle-less injector |
US6960192B1 (en) | 2002-04-23 | 2005-11-01 | Insulet Corporation | Transcutaneous fluid delivery system |
EA006960B1 (ru) | 2002-05-02 | 2006-06-30 | Па Нолидж Лимитед | Инъекционное устройство |
US6808507B2 (en) | 2002-05-10 | 2004-10-26 | Cambridge Biostability Ltd. | Safety injectors |
CA2485365A1 (en) | 2002-05-13 | 2003-11-20 | Modigenetech Ltd. | Ctp-extended erythropoietin |
US6979316B1 (en) | 2002-05-23 | 2005-12-27 | Seedlings Life Science Ventures Llc | Apparatus and method for rapid auto-injection of medication |
EP1511526A1 (en) | 2002-05-24 | 2005-03-09 | Eli Lilly And Company | Medical syringe pump with motor driven piston |
EP2316922B1 (en) | 2002-05-24 | 2013-05-22 | Merck Sharp & Dohme Corp. | Neutralizing human anti-IGFR antibody |
US7553294B2 (en) | 2002-05-30 | 2009-06-30 | Medrad, Inc. | Syringe plunger sensing mechanism for a medical injector |
US7811260B2 (en) | 2002-05-31 | 2010-10-12 | Vidacare Corporation | Apparatus and method to inject fluids into bone marrow and other target sites |
US8641715B2 (en) | 2002-05-31 | 2014-02-04 | Vidacare Corporation | Manual intraosseous device |
US7150724B2 (en) | 2002-06-05 | 2006-12-19 | Cardinal Health 303, Inc. | Syringe plunger driver system |
US8034904B2 (en) | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
TWI314464B (en) | 2002-06-24 | 2009-09-11 | Alza Corp | Reusable, spring driven autoinjector |
JP2006504406A (ja) | 2002-06-28 | 2006-02-09 | セントカー・インコーポレーテツド | 哺乳動物のch1欠失ミメティボディ、組成物、方法および使用 |
AU2003256336A1 (en) | 2002-06-28 | 2004-01-19 | Centocor, Inc. | Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses |
DE10229122B4 (de) | 2002-06-28 | 2006-09-07 | Tecpharma Licensing Ag | Verabreichungsgerät mit rücksetzbarer Betätigungssperre |
EP2286857A1 (en) | 2002-07-02 | 2011-02-23 | Panasonic Corporation | Automatic administration instrument for medical use |
US7328064B2 (en) | 2002-07-04 | 2008-02-05 | Inovio As | Electroporation device and injection apparatus |
AU2003246486A1 (en) | 2002-07-19 | 2004-02-09 | Cangene Corporation | Pegylated erythropoietic compounds |
AU2003254950A1 (en) | 2002-08-26 | 2004-03-11 | Kirin Beer Kabushiki Kaisha | Peptides and drugs containing the same |
TWI289668B (en) | 2002-09-06 | 2007-11-11 | Amgen Inc | Therapeutic human anti-IL-1R1 monoclonal antibody |
RU2328505C2 (ru) | 2002-09-11 | 2008-07-10 | Фрезениус Каби Дойчланд Гмбх | Полипептиды, обработанные has, особенно эритропоэтин, обработанный has |
US6919426B2 (en) | 2002-09-19 | 2005-07-19 | Amgen Inc. | Peptides and related molecules that modulate nerve growth factor activity |
US7135027B2 (en) | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
TWI320716B (en) | 2002-10-14 | 2010-02-21 | Abbott Lab | Erythropoietin receptor binding antibodies |
US7396913B2 (en) | 2002-10-14 | 2008-07-08 | Abbott Laboratories | Erythropoietin receptor binding antibodies |
US20040071694A1 (en) | 2002-10-14 | 2004-04-15 | Devries Peter J. | Erythropoietin receptor binding antibodies |
AU2003285874A1 (en) | 2002-10-16 | 2004-05-04 | Amgen Inc. | HUMAN ANTI-IFN-Gamma NEUTRALIZING ANTIBODIES AS SELECTIVE IFN-Gamma PATHWAY INHIBITORS |
US20040091961A1 (en) | 2002-11-08 | 2004-05-13 | Evans Glen A. | Enhanced variants of erythropoietin and methods of use |
AU2003275895B2 (en) | 2002-11-25 | 2009-02-05 | Tecpharma Licensing Ag | Auto-injector comprising a resettable releasing safety device |
EP1572270A1 (de) | 2002-11-25 | 2005-09-14 | Tecpharma Licensing AG | Injektionsvorrichtung mit nadelschutz |
WO2004047896A1 (de) | 2002-11-25 | 2004-06-10 | Tecpharma Licensing Ag | Vorrichtung zum vorrübergehenden festhalten einer nadelschutzkappe einer injektionsvorrichtung |
GB0229345D0 (en) | 2002-12-17 | 2003-01-22 | Safe T Ltd | Hollow needle applicators |
AU2003301195B2 (en) | 2002-12-20 | 2010-01-07 | Amgen Inc. | Binding agents which inhibit myostatin |
US6767336B1 (en) | 2003-01-09 | 2004-07-27 | Sheldon Kaplan | Automatic injector |
US7699804B2 (en) | 2003-01-31 | 2010-04-20 | Creare Inc. | Fluid ejection system |
EP1603948A1 (en) | 2003-03-14 | 2005-12-14 | Pharmacia Corporation | Antibodies to igf-i receptor for the treatment of cancers |
CA2433205A1 (en) | 2003-03-18 | 2004-09-18 | James Alexander Keenan | Drug delivery, bodily fluid drainage, and biopsy device with enhanced ultrasonic visibility |
JP4762131B2 (ja) | 2003-03-24 | 2011-08-31 | ノボ・ノルデイスク・エー/エス | 薬用カートリッジの透明な電子マーキング |
ATE549359T1 (de) | 2003-04-02 | 2012-03-15 | Hoffmann La Roche | Antikörper gegen den insulinähnlichen wachstumsfaktor i-rezeptor und deren verwendungen |
TWI235706B (en) | 2003-04-07 | 2005-07-11 | Sumitomo Heavy Industries | Method of controlling injection molding machine |
US8383158B2 (en) | 2003-04-15 | 2013-02-26 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
US7220410B2 (en) | 2003-04-18 | 2007-05-22 | Galaxy Biotech, Llc | Monoclonal antibodies to hepatocyte growth factor |
WO2005016970A2 (en) | 2003-05-01 | 2005-02-24 | Imclone Systems Incorporated | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
US6805686B1 (en) | 2003-05-06 | 2004-10-19 | Abbott Laboratories | Autoinjector with extendable needle protector shroud |
AU2004238870B8 (en) | 2003-05-12 | 2010-04-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
KR20120094001A (ko) | 2003-05-12 | 2012-08-23 | 아피맥스, 인크. | 에리스로포이에틴 수용체에 결합하는 펩티드 |
DE602004028725D1 (de) | 2003-05-12 | 2010-09-30 | Affymax Inc | Neue poly(ethylenglycol) modifizierte erythropoietinagonisten und deren verwendungen |
US7074755B2 (en) | 2003-05-17 | 2006-07-11 | Centocor, Inc. | Erythropoietin conjugate compounds with extended half-lives |
EP1633417B1 (en) | 2003-05-30 | 2007-01-31 | Eli Lilly And Company | Multiple chamber medication dispensing apparatus |
CN1826131A (zh) | 2003-05-30 | 2006-08-30 | 森托科尔公司 | 利用转谷氨酰胺酶形成新的促红细胞生成素缀合物 |
WO2005001136A1 (en) | 2003-06-04 | 2005-01-06 | Irm Llc | Methods and compositions for modulating erythropoietin expression |
AR046071A1 (es) | 2003-07-10 | 2005-11-23 | Hoffmann La Roche | Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos |
MEP31508A (en) | 2003-07-15 | 2010-10-10 | Amgen Inc | Human anti-ngf neutralizing antibodies as selective ngf pathway inhibitors |
PL1648998T3 (pl) | 2003-07-18 | 2015-03-31 | Amgen Inc | Specyficzne czynniki wiążące czynnik wzrostu hepatocytów |
US7500963B2 (en) * | 2003-07-22 | 2009-03-10 | Safety Syringes, Inc. | Systems and methods for automatic medical injection with safeguard |
US20050019914A1 (en) | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
US20050022823A1 (en) | 2003-07-30 | 2005-02-03 | Suzanne Davison | Apparatus, system and method for treating dry eye conditions and promoting healthy eyes |
US20050027255A1 (en) | 2003-07-31 | 2005-02-03 | Sid Technologies, Llc | Automatic injector |
DE20311996U1 (de) | 2003-08-01 | 2003-10-16 | Hoelzle Dieter Tech Projekte | Injektionsvorrichtung |
US20090018505A1 (en) | 2003-08-11 | 2009-01-15 | Andrew Arguedas | Powered automatic injection device |
AU2004266131C1 (en) | 2003-08-12 | 2010-12-16 | Eli Lilly And Company | Medication dispensing apparatus with triple screw threads for mechanical advantage |
US7097637B2 (en) | 2003-08-27 | 2006-08-29 | C. R. Bard, Inc. | Safety needle with positive flush |
JP2007512001A (ja) | 2003-08-28 | 2007-05-17 | バイオレクシス ファーマシューティカル コーポレイション | Epoミメティックペプチドおよび融合タンパク質 |
DE10339794A1 (de) | 2003-08-28 | 2005-04-07 | Tecpharma Licensing Ag | Verabreichungsvorrichtung mit einer Schutzkappenabziehvorrichtung und einer Nadelschutzhülsenblockiereinrichtung |
BRPI0409650A (pt) | 2003-09-09 | 2006-04-25 | Warren Pharmaceuticals Inc | métodos para regular o nìvel hematócrito e humanos, produtos de eritropoietina artificial, métodos para preparar um produto de eritropoietina e pra tratar anemia em pacientes em risco de dano no tecido, e, composição farmacêutica |
DE10342059B4 (de) | 2003-09-11 | 2007-03-01 | Tecpharma Licensing Ag | Verabreichungsvorrichtung mit Einstech- und Ausschütteinrichtung |
IL157984A (en) | 2003-09-17 | 2015-02-26 | Dali Medical Devices Ltd | Automatic needle |
US8422413B2 (en) | 2003-09-18 | 2013-04-16 | Dentsply International Inc. | Process and device for the wireless transmission of dental process data |
JP4767857B2 (ja) | 2003-09-30 | 2011-09-07 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ベンゾイミダゾール化合物 |
UA89481C2 (uk) | 2003-09-30 | 2010-02-10 | Центокор, Инк. | Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування |
AU2004277306A1 (en) | 2003-10-03 | 2005-04-14 | Novo Nordisk A/S | Container comprising code information elements |
JP2005131007A (ja) | 2003-10-29 | 2005-05-26 | Nemoto Kyorindo:Kk | 薬液注入システム |
US7635348B2 (en) | 2003-11-04 | 2009-12-22 | Meridian Medical Technologies, Inc. | Container for medicament automatic injector and automatic injector adapted therefor |
DE10351594A1 (de) | 2003-11-05 | 2005-06-16 | Tecpharma Licensing Ag | Vorrichtung für die Verabreichung eines injizierbaren Produkts |
DE10351596B4 (de) | 2003-11-05 | 2007-10-11 | Tecpharma Licensing Ag | Autoinjektor mit variabler Dosis |
UA93653C2 (ru) | 2003-11-07 | 2011-03-10 | Иммунекс Корпорейшн | Выделенное антитело, kotopoe специфически связывается c человеческим рецептором il-4 (il-4r) |
PE20050928A1 (es) | 2003-11-21 | 2005-11-08 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti-igfr1 |
KR20060120141A (ko) | 2003-11-24 | 2006-11-24 | 네오스 테크놀로지스, 인크. | 글리코페질화 에리트로포이에틴 |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
US7666169B2 (en) | 2003-11-25 | 2010-02-23 | Medrad, Inc. | Syringe and syringe plungers for use with medical injectors |
US20050177395A1 (en) | 2003-12-04 | 2005-08-11 | Blomquist Michael L. | Programming medical pumps with electronic standing order template |
WO2005058967A2 (en) | 2003-12-16 | 2005-06-30 | Pierre Fabre Medicament | Novel anti-insulin/igf-i hybrid receptor or anti-insulin/igf-i hybrid receptor and igf-ir antibodies and uses thereof |
CH696421A5 (de) | 2003-12-18 | 2007-06-15 | Tecpharma Licensing Ag | Autoinjektor mit Arretierung des Wirkstoffbehälters. |
WO2005058396A1 (de) | 2003-12-18 | 2005-06-30 | Tecpharma Licensing Ag | Auslösbares injektionsgerät |
EP1548031A1 (en) | 2003-12-22 | 2005-06-29 | Dubai Genetics FZ-LLC | Nature-identical erythropoietin |
RU2370276C2 (ru) | 2003-12-31 | 2009-10-20 | Мерк Патент Гмбх | Fc-ЭРИТРОПОЭТИН СЛИТЫЙ БЕЛОК С УЛУЧШЕННОЙ ФАРМАКОКИНЕТИКОЙ |
US7273469B1 (en) | 2003-12-31 | 2007-09-25 | Advanced Cardiovascular Systems, Inc. | Modified needle catheter for directional orientation delivery |
AU2004311796A1 (en) | 2003-12-31 | 2005-07-21 | Centocor, Inc. | Novel recombinant proteins with N-terminal free thiol |
US7423139B2 (en) | 2004-01-20 | 2008-09-09 | Insight Biopharmaceuticals Ltd. | High level expression of recombinant human erythropoietin having a modified 5′-UTR |
WO2005070451A1 (en) | 2004-01-22 | 2005-08-04 | Zafena Aktiebolag | Pharmaceutical composition comprising non-glycosylated erythropoietin |
AU2005205966B2 (en) | 2004-01-23 | 2010-08-05 | Shl Medical Ag | Injection device |
DE102004005311A1 (de) | 2004-02-03 | 2005-08-18 | Tecpharma Licensing Ag | Ampullenerkennung |
US7670314B2 (en) | 2004-02-17 | 2010-03-02 | Children's Hospital Medical Center | Injection device for administering a vaccine |
KR101136115B1 (ko) * | 2004-02-18 | 2012-04-17 | 아레스 트레이딩 에스.아. | 손에 들고 사용하며, 전자적으로 제어되어 액체 약물을주사하기 위한 주사장치 |
WO2005084711A1 (fr) | 2004-03-02 | 2005-09-15 | Chengdu Institute Of Biological Products | Erythropoietine recombinante pegylee a activite in vivo |
EP1570875A1 (en) | 2004-03-04 | 2005-09-07 | Roche Diagnostics GmbH | Pyrotechnically driven needle-free liquid jet injection device with low-cost components and production |
JP4549079B2 (ja) | 2004-03-05 | 2010-09-22 | パナソニック株式会社 | 医療用投与器具 |
WO2005092369A2 (en) | 2004-03-11 | 2005-10-06 | Fresenius Kabi Deutschland Gmbh | Conjugates of hydroxyethyl starch and erythropoietin |
JP2007529243A (ja) | 2004-03-16 | 2007-10-25 | グレノード・ピイティワイ・リミテッド | 1回使用引込み式注射器 |
WO2005097240A1 (en) | 2004-03-30 | 2005-10-20 | Eli Lilly And Company | Medication dispensing apparatus with gear set having drive member accommodating opening |
CN1938061B (zh) | 2004-03-30 | 2010-10-06 | 诺和诺德公司 | 包括检测装置的致动器系统 |
JP4507671B2 (ja) | 2004-03-31 | 2010-07-21 | パナソニック株式会社 | 医療用投与器具 |
DK1732627T3 (da) | 2004-03-31 | 2010-08-16 | Lilly Co Eli | Injektionsapparat, som har en nålekassette til afgivelse af en farmaceutisk væske |
US20050227289A1 (en) | 2004-04-09 | 2005-10-13 | Reilly Edward B | Antibodies to erythropoietin receptor and uses thereof |
AU2005235794A1 (en) | 2004-04-23 | 2005-11-03 | Cambridge Antibody Technology Limited | Erythropoietin protein variants |
GB2414399B (en) | 2004-05-28 | 2008-12-31 | Cilag Ag Int | Injection device |
GB2414404B (en) | 2004-05-28 | 2009-06-03 | Cilag Ag Int | Injection device |
GB2414405B (en) | 2004-05-28 | 2009-01-14 | Cilag Ag Int | Injection device |
BRPI0513029A (pt) | 2004-07-07 | 2008-04-22 | Lundbeck & Co As H | método para produzir uma proteìna de eritropoietina carbamilada, proteìna de eritropoietina carbamilada, composto, composição farmacêutica, métodos de tratamento de uma doença ou condição crÈnica, sub-crÈnica e aguda e de tratamento de uma doença do sistema nervoso central ou sistema nervoso periférico, e, uso de um composto |
JP4925828B2 (ja) | 2004-07-14 | 2012-05-09 | 株式会社根本杏林堂 | 薬液注入システム |
FR2873699B1 (fr) | 2004-07-29 | 2009-08-21 | Pierre Fabre Medicament Sa | Nouveaux anticorps anti igf ir rt leurs utilisations |
US7449012B2 (en) | 2004-08-06 | 2008-11-11 | Meridian Medical Technologies, Inc. | Automatic injector |
US7255684B2 (en) | 2004-08-09 | 2007-08-14 | Boris Zubry | Medical injection system |
DE102004039020B4 (de) | 2004-08-11 | 2018-01-25 | Tecpharma Licensing Ag | Autoinjektor |
WO2006029094A2 (en) | 2004-09-02 | 2006-03-16 | Xencor, Inc. | Erythropoietin derivatives with altered immunogenicity |
EP1827537B1 (en) | 2004-10-21 | 2019-08-14 | Novo Nordisk A/S | Medication delivery system with a detector for providing a signal indicative of an amount of an ejected dose of drug |
WO2006052737A1 (en) | 2004-11-04 | 2006-05-18 | Sid Technologies, Llc | Automatic injector |
CA2586915A1 (en) | 2004-11-10 | 2006-05-18 | Aplagen Gmbh | Molecules which promote hematopoiesis |
CN101115515B (zh) | 2004-11-11 | 2010-10-13 | 株式会社根本杏林堂 | 化学液体注射系统 |
US20090149744A1 (en) | 2004-11-18 | 2009-06-11 | Shigeru Nemoto | Chemical liquid infusion system |
US7648483B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US7648482B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems, and methods for medicament delivery |
EP1814615B1 (en) | 2004-11-24 | 2015-10-28 | SHL Group AB | Injection device |
US7905352B2 (en) | 2004-12-06 | 2011-03-15 | Washington Biotech Corporation | Kits containing medicine injection devices and containers |
NZ554828A (en) | 2004-12-06 | 2010-07-30 | Washington Biotech Corp | Medicine injection devices and methods |
MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
WO2006081171A1 (en) | 2005-01-24 | 2006-08-03 | Amgen Inc. | Humanized anti-amyloid antibody |
CA2762072C (en) | 2005-02-01 | 2017-08-29 | Intelliject, Inc. | Devices, systems, and methods for medicament delivery |
US8226610B2 (en) | 2005-02-01 | 2012-07-24 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
US7731686B2 (en) | 2005-02-01 | 2010-06-08 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US20060258986A1 (en) | 2005-02-11 | 2006-11-16 | Hunter Ian W | Controlled needle-free transport |
EP1858568A2 (en) | 2005-02-14 | 2007-11-28 | Novo Nordisk A/S | A dosing operation in a medical device |
JP2008529689A (ja) | 2005-02-21 | 2008-08-07 | ノボ・ノルデイスク・エー/エス | 注射装置内のモータ速度を一定に保つ方法 |
JP4762571B2 (ja) | 2005-02-24 | 2011-08-31 | 昭和薬品化工株式会社 | 歯科用カートリッジ式電動注射器における薬液注入速度制御装置 |
GB2424836B (en) | 2005-04-06 | 2010-09-22 | Cilag Ag Int | Injection device (bayonet cap removal) |
GB2427826B (en) | 2005-04-06 | 2010-08-25 | Cilag Ag Int | Injection device comprising a locking mechanism associated with integrally formed biasing means |
EP1870121A1 (en) | 2005-04-11 | 2007-12-26 | Nemoto Kyorindo Co., Ltd. | Medical liquid injection system |
US7390319B2 (en) | 2005-04-13 | 2008-06-24 | Steven Friedman | Automatic needle injector having safety triggering mechanism |
FR2884721A1 (fr) | 2005-04-20 | 2006-10-27 | Becton Dickinson France Soc Pa | Ensemble d'injection et dispositif d'assistance a l'injection |
US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
US8277415B2 (en) | 2006-08-23 | 2012-10-02 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with drive device for driving plunger in reservoir |
US7831545B1 (en) * | 2005-05-31 | 2010-11-09 | Google Inc. | Identifying the unifying subject of a set of facts |
US9011386B2 (en) | 2005-06-01 | 2015-04-21 | Shl Group Ab | Device for delivering medicament |
CN101613409B (zh) | 2005-06-17 | 2014-06-04 | 英克隆有限责任公司 | 抗-PDGFRα抗体 |
US7918824B2 (en) | 2005-06-21 | 2011-04-05 | Eli Lilly And Company | Needled pharmaceutical delivery device with triggered automatic needle insertion and manually controlled pharmaceutical injection |
WO2007000328A1 (en) | 2005-06-27 | 2007-01-04 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Antibodies that bind to an epitope on insulin-like growth factor 1 receptor and uses thereof |
US7955304B2 (en) | 2005-07-15 | 2011-06-07 | Shl Group Ab | Injector |
EP2397497A3 (en) | 2005-07-18 | 2013-11-27 | Amgen, Inc | Human anti-B7RP1 neutralizing antibodies |
FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
US20070025879A1 (en) | 2005-07-27 | 2007-02-01 | Dakocytomation Denmark A/S | Method and apparatus for syringe-based sample introduction within a flow cytometer |
PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
JP4850457B2 (ja) | 2005-09-06 | 2012-01-11 | キヤノン株式会社 | 薄膜トランジスタ及び薄膜ダイオード |
US8202249B2 (en) | 2005-09-20 | 2012-06-19 | Panasonic Corporation | Injection device with puncture function, method for controlling injection device with puncture function, chemical solution administration device, and method for controlling chemical solution administration device |
JP4983180B2 (ja) | 2005-09-20 | 2012-07-25 | パナソニック株式会社 | 穿刺機能付注射装置、穿刺機能付注射装置の制御方法、薬液投与装置、および薬液投与装置の制御方法 |
US7534226B2 (en) | 2005-09-26 | 2009-05-19 | M2 Group Holdings, Inc. | Dispensing fluid from an infusion pump system |
EP1948112A4 (en) | 2005-10-11 | 2011-04-13 | Podaima Blake | SMART MEDICAL COMPLIANCE PROCESS AND SYSTEM |
CA2619454A1 (en) | 2005-10-11 | 2007-04-26 | Eli Lilly And Company | Apparatus for injecting a pharmaceutical |
WO2007044980A2 (en) | 2005-10-13 | 2007-04-19 | Argos Therapeutics, Inc. | Devices, systems and related methods suitable for delivery of a liquid medicament stored at cryogenic temperatures |
US7713232B2 (en) | 2005-11-04 | 2010-05-11 | Medrad, Inc. | System for washing and processing of cells for delivery thereof to tissue |
JP2007127086A (ja) | 2005-11-04 | 2007-05-24 | Terumo Corp | ポンプ |
US7988675B2 (en) | 2005-12-08 | 2011-08-02 | West Pharmaceutical Services Of Delaware, Inc. | Automatic injection and retraction devices for use with pre-filled syringe cartridges |
JP5112330B2 (ja) | 2005-12-20 | 2013-01-09 | アンタレス・ファーマ・インコーポレーテッド | 無針注入デバイス |
US20070173770A1 (en) | 2006-01-23 | 2007-07-26 | The Medical House Plc | Injection device |
GB0601309D0 (en) | 2006-01-23 | 2006-03-01 | Medical House The Plc | Injection device |
NZ569395A (en) | 2006-01-31 | 2010-12-24 | Ares Trading Sa | Injection device with a capacitive proximity sensor including an elextrode with a concave shape |
TW200744697A (en) | 2006-02-28 | 2007-12-16 | Verus Pharmaceuticals Inc | Shock absorber for an automatic injector |
US20090005735A1 (en) | 2006-03-03 | 2009-01-01 | Shl Group Ab | Medical Device with Orientation Sensitive Priming Mechanism |
GB2449027B (en) | 2006-03-29 | 2011-07-13 | Intelliject Inc | Devices, systems and methods for medicament delivery |
FR2899482A1 (fr) | 2006-04-11 | 2007-10-12 | Becton Dickinson France Soc Pa | Dispositif d'injection automatique |
DE102006017209A1 (de) | 2006-04-12 | 2007-10-18 | Tecpharma Licensing Ag | Injektionsvorrichtung mit Spannfeder und Spannelement |
JP4982722B2 (ja) | 2006-04-19 | 2012-07-25 | ノボ・ノルデイスク・エー/エス | 流体注入システム、同システムの組み立て方法、及び同システムに使用される薬剤容器 |
TWI395754B (zh) | 2006-04-24 | 2013-05-11 | Amgen Inc | 人類化之c-kit抗體 |
DE602007004972D1 (de) | 2006-05-16 | 2010-04-08 | Novo Nordisk As | Getriebemechanismus für ein injektionsgerät |
CN103255162A (zh) | 2006-05-19 | 2013-08-21 | 格利科菲公司 | 促红细胞生成素组合物 |
GB2438590B (en) | 2006-06-01 | 2011-02-09 | Cilag Gmbh Int | Injection device |
GB2438629B (en) | 2006-06-01 | 2011-02-23 | Cilag Gmbh Int | Injection device |
AU2007257173B2 (en) | 2006-06-07 | 2013-03-14 | Acushot Inc. | Charging mechanism for a needle-free injector |
TWI542374B (zh) | 2006-06-30 | 2016-07-21 | 艾伯維生物技術有限責任公司 | 自動注射裝置 |
JP5149798B2 (ja) | 2006-07-06 | 2013-02-20 | 株式会社根本杏林堂 | 薬液充填注入システムおよび薬液充填装置 |
JP2009543629A (ja) * | 2006-07-15 | 2009-12-10 | ノボ・ノルデイスク・エー/エス | 非対称のコード化手段を有する薬剤投与システム |
US7618396B2 (en) | 2006-08-09 | 2009-11-17 | Avant Medical Corp. | Injection system with hidden needles |
US7681606B2 (en) | 2006-08-10 | 2010-03-23 | Fht, Inc. | Automated system and process for filling drug delivery devices of multiple sizes |
US7736338B2 (en) | 2006-08-23 | 2010-06-15 | Medtronic Minimed, Inc. | Infusion medium delivery system, device and method with needle inserter and needle inserter device and method |
DE102006053055A1 (de) | 2006-09-01 | 2008-04-17 | Tecpharma Licensing Ag | Nadelschutzvorrichtung mit blockierter Schutzposition |
CL2007002567A1 (es) | 2006-09-08 | 2008-02-01 | Amgen Inc | Proteinas aisladas de enlace a activina a humana. |
EP3626289B1 (de) | 2006-09-15 | 2020-12-02 | Ypsomed AG | Injektionsgerät mit verbessertem förderelement |
US7833527B2 (en) | 2006-10-02 | 2010-11-16 | Amgen Inc. | Methods of treating psoriasis using IL-17 Receptor A antibodies |
US7811254B2 (en) | 2006-10-18 | 2010-10-12 | Meridian Medical Technologies, Inc. | Autoinjector with needle depth adapter |
US9345831B2 (en) | 2006-10-19 | 2016-05-24 | E3D Agricultural Cooperative Association Ltd | Automatic injection device |
US7760099B2 (en) | 2006-11-03 | 2010-07-20 | Codan Us Corporation | Radio frequency verification system and device |
EP1923083A1 (en) | 2006-11-17 | 2008-05-21 | Sanofi-Aventis Deutschland GmbH | Drive mechanisms for use in drug delivery devices |
EP1923085A1 (en) | 2006-11-17 | 2008-05-21 | Sanofi-Aventis Deutschland GmbH | Dosing and drive mechanism for drug delivery device |
US20100042054A1 (en) * | 2006-11-17 | 2010-02-18 | Novo Nordisk A/S | Medical Delivery System Comprising a Coding Mechanism Between Dosing Assembly and Medicament Container |
EP1923084A1 (en) | 2006-11-17 | 2008-05-21 | Sanofi-Aventis Deutschland GmbH | Dosing and drive mechanism for drug delivery device |
JP5680852B2 (ja) | 2006-11-21 | 2015-03-04 | カレオ,インコーポレイテッド | 薬物送達のための装置 |
FR2908999B1 (fr) * | 2006-11-29 | 2012-04-27 | Biomerieux Sa | Nouveau medicament destine a l'inhibition, la prevention ou le traitement de la polyarthrite rhumatoide. |
US8382713B2 (en) | 2006-12-11 | 2013-02-26 | Kenergy Scientific, Inc. | Drug delivery device and methodology |
GB0625169D0 (en) | 2006-12-18 | 2007-01-24 | Medical House Plc The | Improved autoinjector |
US9326742B2 (en) | 2007-01-01 | 2016-05-03 | Bayer Healthcare Llc | Systems for integrated radiopharmaceutical generation, preparation, transportation and administration |
JP2009526241A (ja) * | 2007-01-09 | 2009-07-16 | マリンクロット インコーポレイテッド | ニードルキャップイジェクターを備えた放射線遮蔽シリンジ |
WO2008095124A1 (en) | 2007-01-31 | 2008-08-07 | Somark Innovations, Inc. | Device and method for providing a readable mark |
JP2010527248A (ja) | 2007-02-01 | 2010-08-12 | ピーエー ノウレッジ リミテッド | 自動注入器及び自動注入器の針を覆うアダプタ |
GB0704351D0 (en) | 2007-03-07 | 2007-04-11 | Medical House Plc The | Improved autoinjector |
CN101641127B (zh) | 2007-03-21 | 2012-11-28 | 诺沃-诺迪斯克有限公司 | 具有容器识别的医药输送系统和用于医药输送系统的容器 |
CN101674857A (zh) | 2007-03-22 | 2010-03-17 | 特克法马许可公司 | 具有触发保险的注射装置 |
EP3865161A1 (de) | 2007-03-22 | 2021-08-18 | Ypsomed AG | Injektionsvorrichtung mit gesteuertem nadelrückzug |
US8597253B2 (en) | 2007-04-20 | 2013-12-03 | Bard Access Systems | Huber needle with safety sheath |
US20100137802A1 (en) | 2007-05-11 | 2010-06-03 | Ofer Yodfat | Methods and appratus for monitoring rotation of an infusion pump driving mechanism |
GB0710433D0 (en) | 2007-05-31 | 2007-07-11 | Ucb Pharma Sa | Auto-injector |
US8171634B2 (en) | 2007-07-09 | 2012-05-08 | Pratt & Whitney Canada Corp. | Method of producing effusion holes |
GB2451665B (en) | 2007-08-08 | 2012-09-26 | Cilag Gmbh Int | Injection device |
EP2051755B1 (en) | 2007-08-23 | 2010-07-07 | Mallinckrodt, Inc. | Syringe content detection using rf energy |
US8012120B2 (en) | 2007-09-13 | 2011-09-06 | Avant Medical Corp. | Device and method for the automatic initiation of an injection |
WO2009040602A1 (en) | 2007-09-25 | 2009-04-02 | Becton Dickinson France | Autoinject0r with deactivating means moveable by a safety shield |
EP2190501A1 (en) | 2007-09-28 | 2010-06-02 | Mallinckrodt Inc. | Coupling of powerhead ram and power injector syringe |
US7922695B2 (en) | 2007-10-18 | 2011-04-12 | Roche Diagnostics Operations, Inc. | Drug delivery pump drive using linear piezoelectric motor |
CN101909674B (zh) | 2007-11-12 | 2013-04-10 | 邦奥鲁夫森梅迪康股份有限公司 | 带有自动针头缩回功能的自动注射装置 |
USD619702S1 (en) | 2007-11-15 | 2010-07-13 | Tecpharma Licensing Ag | Medicine injector |
DE102007055636A1 (de) | 2007-11-21 | 2009-05-28 | Robert Bosch Gmbh | Medikamenten-Dosiervorrichtung zum Verabreichen eines flüssigen Medikaments |
DE102007061775A1 (de) | 2007-12-20 | 2009-07-02 | Geiger Technik Gmbh | Spritzgussverfahren und zugehörige Anlage |
GB0800103D0 (en) | 2008-01-04 | 2008-02-13 | Owen Mumford Ltd | Sheath removver device |
MX2010008099A (es) * | 2008-01-28 | 2010-08-04 | Medimmune Ltd | Anticuerpos y angiopoyetina-2 estabilizados y sus usos. |
US8814834B2 (en) | 2008-03-10 | 2014-08-26 | Antares Pharma, Inc. | Injector safety device |
US20090254060A1 (en) | 2008-04-02 | 2009-10-08 | Hetherington Hugh E | Motor assembly for injection control device |
WO2009125879A1 (en) | 2008-04-07 | 2009-10-15 | Jong-Soo Choi | Automatic injection apparatus |
JP5313236B2 (ja) | 2008-04-10 | 2013-10-09 | パナソニック株式会社 | 薬剤投与装置 |
MY148822A (en) | 2008-05-02 | 2013-06-14 | Sanofi Aventis Deutschland | Medication delivery device |
EP2274029B1 (en) | 2008-05-02 | 2011-11-02 | Sanofi-Aventis Deutschland GmbH | Medication delivery device |
US8052645B2 (en) | 2008-07-23 | 2011-11-08 | Avant Medical Corp. | System and method for an injection using a syringe needle |
US8177749B2 (en) | 2008-05-20 | 2012-05-15 | Avant Medical Corp. | Cassette for a hidden injection needle |
KR20110037979A (ko) | 2008-05-30 | 2011-04-13 | 알러간, 인코포레이티드 | 액체 상태 또는 젤 상태의 연조직 증대 필러, 생활성 제제 및 기타 생체적합성 물질을 위한 주사 장치 |
GB2461088B (en) | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Injection device |
ATE510575T1 (de) | 2008-06-30 | 2011-06-15 | Animas Corp | Antriebsmechanismus |
WO2010006870A1 (en) | 2008-07-15 | 2010-01-21 | Shl Group Ab | Medicament delivery device |
PL2326371T3 (pl) | 2008-07-18 | 2020-02-28 | Ucb Biopharma Sprl | Systemy podawania leków dla pacjentów z reumatoidalnym zapaleniem stawów |
CA2732812C (en) | 2008-08-05 | 2017-10-31 | Antares Pharma, Inc. | Multiple dosage injector |
ES2528596T3 (es) | 2008-08-08 | 2015-02-10 | Mallinckrodt Llc | Inyector automático con función automática de autodirección de ariete |
DE102008037310B4 (de) | 2008-08-11 | 2023-11-16 | Ypsomed Ag | Automatische Injektionsvorrichtung für die Verabreichung einer festen Dosis |
USD636077S1 (en) | 2008-08-27 | 2011-04-12 | Deka Products Limited Partnership | Fluidic connector |
GB2463034B (en) * | 2008-08-28 | 2012-11-07 | Owen Mumford Ltd | Autoinjection devices |
GB2463071A (en) | 2008-09-02 | 2010-03-03 | Owen Mumford Ltd | Auto-injector syringe with safety shield |
WO2010029054A1 (en) | 2008-09-10 | 2010-03-18 | F. Hoffmann-La Roche Ag | Delivery device for use with a therapeutic drug |
EP2326370B1 (en) | 2008-09-18 | 2020-08-05 | Becton, Dickinson and Company | Medical injector with slidable sleeve activation |
ES2677902T3 (es) | 2008-09-29 | 2018-08-07 | Becton Dickinson France | Dispositivo de inyección automática |
WO2010041592A1 (ja) | 2008-10-06 | 2010-04-15 | テルモ株式会社 | シリンジポンプ |
USD619706S1 (en) | 2008-11-11 | 2010-07-13 | Artema Medical Ab | Pneumatic connector |
ES2567715T3 (es) | 2008-11-17 | 2016-04-26 | Becton Dickinson And Company | Dispositivo de fuerza adicional para pluma de administración de medicamento para inyección de medicación intradérmica |
DE102008063517A1 (de) | 2008-12-18 | 2010-07-01 | Lts Lohmann Therapie-Systeme Ag | Einmalinjektor mit einem biegeelastischen Gehäuse II |
EP3216471B1 (en) | 2008-12-29 | 2018-12-12 | Sanofi-Aventis Deutschland GmbH | Medical injection device with electric motor drive control |
US8152779B2 (en) | 2008-12-30 | 2012-04-10 | Medimop Medical Projects Ltd. | Needle assembly for drug pump |
JP5752053B2 (ja) | 2009-02-04 | 2015-07-22 | マリンクロッド エルエルシー | 視覚的な使用表示を有するシリンジ |
DK2393534T3 (en) * | 2009-02-05 | 2015-11-23 | Sanofi Aventis Deutschland | ANORDNINGAR FÖR TILLDELNING AV Läkemedel |
WO2010100213A1 (en) | 2009-03-05 | 2010-09-10 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device |
MX2011010101A (es) | 2009-03-30 | 2011-10-19 | Sanofi Aventis Deutschland | Dispositivo de administracion de farmaco con un vastago de piston mejorado. |
EP2414011B1 (en) | 2009-04-01 | 2016-04-27 | SHL Group AB | Medicament delivery device |
EP2416823A1 (en) | 2009-04-08 | 2012-02-15 | Mallinckrodt LLC | Medical fluid delivery system with reusable rfid fixture |
US8529503B2 (en) | 2009-04-24 | 2013-09-10 | Shl Group Ab | Medicament delivery device |
US20110023281A1 (en) * | 2009-04-30 | 2011-02-03 | Stat Medical Devices, Inc. | Pen injection device cap with integral pen needle quick release and/or removal system |
NZ596182A (en) | 2009-05-07 | 2014-03-28 | Medical Injection Devices Inc | Medicament dispensing device |
CA3068441C (en) | 2009-07-29 | 2024-01-09 | Icu Medical, Inc. | Fluid transfer devices and methods of use |
EP2292286A1 (en) | 2009-09-07 | 2011-03-09 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a medication delivery device and medication delivery device |
DE102009048497A1 (de) | 2009-09-26 | 2011-03-31 | Haselmeier Gmbh | Injektionsgerät |
TW201127435A (en) | 2009-09-30 | 2011-08-16 | Sanofi Aventis Deutschland | Drive mechanism for a drug delivery device |
US20110097229A1 (en) | 2009-10-09 | 2011-04-28 | Cauley Iii Thomas Henry | Feedback Controlled Syringe Pump |
EA023390B1 (ru) | 2009-10-16 | 2016-05-31 | Янссен Байотек, Инк. | Устройство для доставки лекарственных веществ, приводимое в действие ладонью руки |
WO2011057065A1 (en) | 2009-11-06 | 2011-05-12 | The Uab Research Foundation | Apparatuses and methods for delivering substances to the inner eye |
US8394053B2 (en) * | 2009-11-06 | 2013-03-12 | Crisi Medical Systems, Inc. | Medication injection site and data collection system |
USD637713S1 (en) | 2009-11-20 | 2011-05-10 | Carmel Pharma Ab | Medical device adaptor |
CN102686257B (zh) | 2009-12-07 | 2014-09-03 | 赛诺菲-安万特德国有限公司 | 用于药物传输装置的驱动组件和药物传输装置 |
JP5951505B2 (ja) | 2010-01-22 | 2016-07-13 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | コード化された折り畳み可能な薬物リザーバ |
JP5598903B2 (ja) | 2010-01-29 | 2014-10-01 | 富士電機エフテック株式会社 | 薬液用電動注射器 |
EP2351591A1 (en) | 2010-02-02 | 2011-08-03 | Sanofi-Aventis Deutschland GmbH | Assembly for a drug delivery device and drug delivery device |
CA2790190A1 (en) | 2010-02-17 | 2011-08-25 | Sanofi-Aventis Deutschland Gmbh | Automatic injection device with torsional spring |
JP5872490B2 (ja) | 2010-02-18 | 2016-03-01 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | クラッチ機構 |
US8911410B2 (en) | 2010-02-18 | 2014-12-16 | Sanofi-Aventis Deutschland Gmbh | Auto-injector |
WO2011101381A2 (en) | 2010-02-22 | 2011-08-25 | Sanofi-Aventis Deutschland Gmbh | Gearbox |
JP5671730B2 (ja) | 2010-03-01 | 2015-02-18 | パナソニックヘルスケアホールディングス株式会社 | 薬剤投与装置 |
US20110270220A1 (en) | 2010-03-03 | 2011-11-03 | Aktivpak, Inc. | Linearly actuated dispenser and therapeutic package suitable for administering a therapeutic substance and related method |
USD625015S1 (en) | 2010-03-12 | 2010-10-05 | Sonosite, Inc. | Medical device stand docking station |
IL211800A (en) | 2010-03-21 | 2014-03-31 | Isaac Zukier | Liquid or clot injection device |
JP2013523294A (ja) | 2010-04-09 | 2013-06-17 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬物送達デバイスを識別するための方法及びシステム |
CA2736841C (en) | 2010-04-15 | 2014-02-18 | Teneo Innovations Inc. | Device and electronic controller for syringe piston control |
MX369242B (es) | 2010-05-20 | 2019-11-01 | Becton Dickinson Co | Dispositivo de administracion de farmacos. |
US20130190719A1 (en) | 2010-06-11 | 2013-07-25 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device with drive member having indication elements |
DK2579927T3 (en) | 2010-06-11 | 2018-06-06 | Sanofi Aventis Deutschland | DRIVE MECHANISM FOR A PHARMACEUTICAL DISPENSER AND MEDICINE DISPENSER |
US8961473B2 (en) | 2010-06-11 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for a drug delivery device and drug delivery device |
EP2399627A1 (en) | 2010-06-28 | 2011-12-28 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
CN105747218A (zh) * | 2010-06-28 | 2016-07-13 | 雀巢产品技术援助有限公司 | 低热量、高蛋白质营养组合物及其应用方法 |
EP2399634A1 (en) | 2010-06-28 | 2011-12-28 | Sanofi-Aventis Deutschland GmbH | Needle safety arrangement and method for operating it |
CA2808469A1 (en) * | 2010-08-19 | 2012-02-23 | Sanofi-Aventis Deutschland Gmbh | Method and system for determining information related to a drug reservoir using an electronic sensor |
USD642261S1 (en) | 2010-09-15 | 2011-07-26 | Abbott Medical Optics Inc. | Securing device for cannula attachment to syringe body |
USD650070S1 (en) | 2010-09-16 | 2011-12-06 | Panasonic Corporation | Injector |
EP2438949A1 (en) | 2010-10-06 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a drug delivery device and drug delivery device |
EP2438946A1 (en) | 2010-10-08 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
EP2438942A1 (en) | 2010-10-08 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
DK2635334T3 (en) | 2010-11-03 | 2014-11-17 | Sanofi Aventis Deutschland | System for prevention of leak of a drug |
TWI464002B (zh) * | 2010-11-08 | 2014-12-11 | Shl Group Ab | 容器支撐總成和藥物輸送裝置總成 |
EP2452711A1 (en) | 2010-11-12 | 2012-05-16 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a drug delivery device and drug delivery device |
US8609621B2 (en) | 2010-11-15 | 2013-12-17 | E I Du Pont De Nemours And Company | Acid-cleavable linkers exhibiting altered rates of acid hydrolysis |
EP2460553A1 (fr) | 2010-12-02 | 2012-06-06 | Debiotech S.A. | Dispositif pour l'insertion d'aiguilles |
GB201020472D0 (en) | 2010-12-02 | 2011-01-19 | Oval Medical Technologies Ltd | A drive assembly for an autoinjector |
GB201020475D0 (en) | 2010-12-02 | 2011-01-19 | Oval Medical Technologies Ltd | Delivery mechanism for an autoinjector |
JP6145044B2 (ja) | 2010-12-17 | 2017-06-07 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬剤投与 |
EP2468329A1 (en) | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Auto injector with a torsion spring |
EP2468333A1 (en) | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
USD679008S1 (en) | 2011-01-07 | 2013-03-26 | Remot Medical Innovation, LLC | Endotracheal tube adaptor |
CA2824454C (en) | 2011-01-24 | 2018-10-23 | Abbvie Biotechnology Ltd. | Removal of needle shields from syringes and automatic injection devices |
USD677380S1 (en) | 2011-01-24 | 2013-03-05 | Abbvie Biotechnology Ltd. | Automatic injection device |
EP2489383A1 (en) | 2011-02-18 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
EP2489390A1 (en) | 2011-02-18 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Detent mechanism |
EP2489385A1 (en) | 2011-02-18 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
GB2488579A (en) | 2011-03-02 | 2012-09-05 | Owen Mumford Ltd | Autoinjector with "injection complete" indicator |
US20120253314A1 (en) | 2011-03-30 | 2012-10-04 | Ziv Harish | Palm-controlled injectors |
SI2699293T1 (sl) | 2011-04-20 | 2019-05-31 | Amgen Inc. | Avtoinjekcijski aparat |
EP4299093A3 (en) | 2011-04-21 | 2024-03-13 | AbbVie Inc. | Wearable automatic injection device for controlled administration of therapeutic agents |
EP2714157B1 (en) | 2011-06-02 | 2016-08-10 | UCB Biopharma SPRL | Auto-injector |
US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
USD679391S1 (en) | 2011-07-19 | 2013-04-02 | Timothy Mark Chinowsky | Cartridge for medical device |
WO2013032841A1 (en) | 2011-08-29 | 2013-03-07 | Sid Technologies Llc | Subcutaneous and intradermal patch infusers |
RU2626132C2 (ru) | 2011-09-09 | 2017-07-21 | Мерк Патент Гмбх | Автоматический инъектор для инъекции адреналина |
EP2583704A1 (en) | 2011-10-21 | 2013-04-24 | Sanofi-Aventis Deutschland GmbH | Autoinjector |
IL216158A0 (en) | 2011-11-06 | 2011-12-29 | Medimop Medical Projects Ltd | Electronic autoinjector apparatus and cassettes for use therewith |
EP2780020A4 (en) | 2011-11-14 | 2016-03-02 | Regenerative Sciences Llc | SUSPENDED PARTICLE DISTRIBUTION SYSTEMS AND METHODS |
USD673677S1 (en) | 2011-12-14 | 2013-01-01 | Insightra Medical, Inc. | Fibrotic band interrupter and implant introducing device |
EP2606925A1 (en) | 2011-12-21 | 2013-06-26 | Sanofi-Aventis Deutschland GmbH | Autoinjector |
USD702835S1 (en) | 2012-01-04 | 2014-04-15 | Anteis Sa | Needle retaining device |
EP2819724B1 (en) | 2012-02-27 | 2019-03-20 | F.Hoffmann-La Roche Ag | Spring force assembly for biasing or actuating stoppers of syringes, injection pen cartridges and the like |
EP2633874A1 (en) | 2012-03-02 | 2013-09-04 | Sanofi-Aventis Deutschland GmbH | Fixed-dose medicament delivery device |
US8603026B2 (en) | 2012-03-20 | 2013-12-10 | Medtronic Minimed, Inc. | Dynamic pulse-width modulation motor control and medical device incorporating same |
US8523803B1 (en) | 2012-03-20 | 2013-09-03 | Medtronic Minimed, Inc. | Motor health monitoring and medical device incorporating same |
US8603027B2 (en) | 2012-03-20 | 2013-12-10 | Medtronic Minimed, Inc. | Occlusion detection using pulse-width modulation and medical device incorporating same |
USD898908S1 (en) | 2012-04-20 | 2020-10-13 | Amgen Inc. | Pharmaceutical product cassette for an injection device |
US9675760B2 (en) | 2012-05-30 | 2017-06-13 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for a drug delivery device and drug delivery device |
EP2674180A1 (en) | 2012-06-15 | 2013-12-18 | Ares Trading S.A. | Injection device |
EP2867528A1 (en) | 2012-06-27 | 2015-05-06 | Sanofi-Aventis Deutschland GmbH | Linear actor arrangement |
CN104684603B (zh) | 2012-08-20 | 2017-11-24 | 卡贝欧洲有限公司 | 自动注射装置 |
US8960827B2 (en) | 2012-08-24 | 2015-02-24 | Ssw Holding Company, Inc. | Anti-tip and retention assembly for appliance support plate |
USD718439S1 (en) | 2012-12-17 | 2014-11-25 | B. Braun Melsungen Ag | Actuator assembly for a valved catheter |
PT2953667T (pt) | 2013-02-11 | 2020-01-28 | Antares Pharma Inc | Dispositivo de injeção a jato auxiliado por agulha tendo força de gatilho reduzida |
US9308321B2 (en) | 2013-02-18 | 2016-04-12 | Medtronic Minimed, Inc. | Infusion device having gear assembly initialization |
JP6030803B2 (ja) | 2013-03-11 | 2016-11-24 | アンタレス・ファーマ・インコーポレーテッド | ピニオンシステムを有する用量注射器 |
TWI639453B (zh) | 2013-03-15 | 2018-11-01 | 美商安美基公司 | 用於注射器之匣盒 |
EP2968760B1 (en) | 2013-03-15 | 2024-01-03 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
DK2991705T3 (da) | 2013-05-01 | 2020-02-03 | Unl Holdings Llc | Stempeldrevne autoinjektorer |
US9340346B2 (en) | 2013-11-21 | 2016-05-17 | Smarthealth, Inc. | Precision dispensing device of small volume from pre-filled syringes |
USD748783S1 (en) | 2014-03-12 | 2016-02-02 | Adhezion Biomedical, Llc | Dispensing applicator |
JP2015186876A (ja) | 2014-03-27 | 2015-10-29 | 日清紡メカトロニクス株式会社 | ダイアフラムシートの製造方法 |
DK3137136T3 (en) | 2014-04-29 | 2018-07-23 | Carebay Europe Ltd | DEVICE FOR ADJUSTING DEADLINE DEPTH |
USD768851S1 (en) | 2014-06-30 | 2016-10-11 | Htl-Strefa Spolka Akcyjna | Safety needle device |
USD768852S1 (en) | 2014-06-30 | 2016-10-11 | Htl-Strefa Spolka Akcyjna | Safety needle device |
USD765241S1 (en) | 2014-09-15 | 2016-08-30 | Owen Mumford Ltd. | Syringe |
USD757254S1 (en) | 2015-01-07 | 2016-05-24 | Sanofi-Aventis Deutschland Gmbh | Autoinjector housing |
-
2012
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- 2012-04-20 MX MX2013012144A patent/MX364177B/es active IP Right Grant
- 2012-04-20 EP EP19154409.7A patent/EP3498323B1/en active Active
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Patent Citations (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH03501216A (ja) * | 1987-09-09 | 1991-03-22 | エピメト クンストシュトッフテヒニク ゲゼルシャフト ミット ベシュレンクテル ハフツング | 変形可能なアンプルを有する注射装置 |
JP2826196B2 (ja) * | 1993-04-02 | 1998-11-18 | エリ リリー アンド カンパニー | 多岐管医薬注射の装置と方法 |
JP2000510021A (ja) * | 1996-10-09 | 2000-08-08 | エクイダイン システムズ インコーポレイティド | ジェット式皮下注射装置 |
WO2009143255A1 (en) * | 2008-05-20 | 2009-11-26 | Avant Medical Corp. | Autoinjector system |
WO2010099850A1 (de) * | 2009-03-03 | 2010-09-10 | Dieter Hölzle Technik-Projekte GmbH | Injektionsvorrichtung mit injektionsvolumeneinstellung |
EP2301611A1 (en) * | 2009-09-25 | 2011-03-30 | Letcat Aktiebolag | Medical delivery device |
JP2014502887A (ja) * | 2010-12-21 | 2014-02-06 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 自動注射器 |
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US10864324B2 (en) | 2008-05-20 | 2020-12-15 | Avant Medical Corp. | Autoinjector system |
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US11724032B2 (en) | 2008-07-23 | 2023-08-15 | Avant Medical Corp. | System and method for an injection using a syringe needle |
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CN113226406A (zh) * | 2018-12-27 | 2021-08-06 | 株式会社大赛璐 | 无针注射器 |
WO2020138475A1 (ja) * | 2018-12-27 | 2020-07-02 | 株式会社ダイセル | 無針注射器 |
CN113226406B (zh) * | 2018-12-27 | 2023-11-03 | 株式会社大赛璐 | 无针注射器 |
EP3903859A4 (en) * | 2018-12-27 | 2022-09-14 | Daicel Corporation | SYRINGE WITHOUT NEEDLE |
JP7119121B2 (ja) | 2018-12-27 | 2022-08-16 | 株式会社ダイセル | 無針注射器 |
JPWO2020138475A1 (ja) * | 2018-12-27 | 2021-09-27 | 株式会社ダイセル | 無針注射器 |
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