JP2018202221A - 自動式注射装置 - Google Patents
自動式注射装置 Download PDFInfo
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- JP2018202221A JP2018202221A JP2018188224A JP2018188224A JP2018202221A JP 2018202221 A JP2018202221 A JP 2018202221A JP 2018188224 A JP2018188224 A JP 2018188224A JP 2018188224 A JP2018188224 A JP 2018188224A JP 2018202221 A JP2018202221 A JP 2018202221A
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- cassette
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Abstract
Description
(i)米国特許出願公開第2006/0040358号明細書(2006年2月23日公開)、米国特許出願公開第2005/0008642号明細書(2005年1月13日公開)、米国特許出願公開第2004/0228859号明細書(2004年11月18日公開)。これら抗体は、限定されないが、例えば、抗体1A(DSMZ寄託番号DSMACC2586)、抗体8(DSMZ寄託番号DSMACC2589)、抗体23(DSMZ寄託番号DSMACC2588)及び上記公報に記載されたような抗体18を含む。
(ii)国際公開第06/138729号(2006年12月28日公開)、国際公開第05/0169709号(2005年2月24日公開)、及びLuなどの2004, J Biol. Chem. 279: 2856 - 65。これら抗体は、限定されないが、上記文献に記載されたような抗体2F8、A12及びIMC−A12を含む。
(iii)国際公開第07/012614号(2007年2月1日公開)、国際公開第07/000328号(2007年1月4日公開)、国際公開第06/013472号(2006年2月9日公開)、国際公開第05/058967号(2005年6月30日公開)及び国際公開第03/059951号(2003年7月24日公開)。
(iv)米国特許出願公開第2005/0084906号明細書(2005年4月21日公開)。これら抗体は、限定されないが、公報に記載されているように、抗体7C10、キメラ抗体C7C10、抗体h7C10、抗体7H2M、キメラ抗体*7C10、抗体GM607、ヒト化抗体7C10バージョン1、ヒト化抗体7C10バージョン2、ヒト化抗体7C10バージョン3、及び、抗体7H2HMを含む。
(v)米国特許出願公開第2005/0249728(2005年11月10日公開)、米国特許出願公開第2005/0186203(2005年8月25日公開)、米国特許出願公開第2004/0265307(2004年12月30日公開)、及び、米国特許出願公開第2003/0235582(2003年12月25日公開)、並びにMaloney等の2003, Cancer Res. 63: 5073 - 83。これら抗体は、文献に記載されているように、限定されないが、抗体EM164、表面再構成されたEM164、ヒト化EM164、huEM164バージョン1.0、huEM164バージョン1.1、huEM164バージョン1.2、及び、huEM164バージョン1.3、を含む。
(vi)米国特許第7037498(2006年5月2日発行)、米国特許出願公開第2005/0244408号明細書(2005年11月30日公開)、米国特許出願公開第2004/0086503号明細書(2004年5月6日)、及び、Cohen等のClinicalCancerRes.11:2063-73、例えば、抗体CP−751、871。これら抗体は、文献に記載されているように、限定されないが、ATCC寄託番号PTA−2792、PTA−2788、PTA−2790、PTA−2791、PTA−2789、PTA−2793を有するハイブリドーマにより生成された抗体、並びに、抗体2.12.1、2.13.2、2.14.3、3.1.1、4.9.2及び4.17.3、のいずれかを含む。
(vii)米国特許出願公開第2005/0136063号明細書(2005年6月23日公開)及び米国特許出願公開第2004/0018191号明細書(2004年1月29日公開)。これら抗体は、公報に記載されているように、限定されないが、抗体19D12と、ATCCの下の番号PTA−5214で寄託されたプラスミド15H12/19D12HCA(γ4)におけるポリヌクレオチドによってコード化された重鎖及びATCCの下の番号PTA−5220で寄託されたプラスミド15H12/19D12LCF(κ)におけるポリヌクレオチドによってコード化された軽鎖を含む抗体と、を含む。
(vii)米国特許出願公開第2004/0202655号明細書(2004年10月14日)。これら抗体は、公報に記載されているように、限定されないが、抗体PINT−6A1、PINT−7A2、PINT−7A4、PINT−7A5、PINT−7A6、PINT−8A1、PINT−9A2、PINT−11A1、PINT−11A2、PINT−11A3、PINT−11A4、PINT−11A5、PINT−11A7、PINT−11A12、PINT−12A1、PINT−12A2、PINT−12A3、PINT−12A4、及びPINT−12A5を含む。
これらそれぞれ及びこれらすべては、その全体を、特にIGF−1受容体を標的とする上記抗体、ペプチボディ及び関連タンパク質などに関して、参考として本願に組み込まれる。
33(抗IFNAR);抗CD38mAb(HuMaxCD38);抗CD40LmAb;抗CriptomAb;抗CTGF特発性肺線維症フェーズIフィブリノゲン(FG−3019);抗CTLA4mAb;抗eotaxin1mAb(CAT−213);抗FGF8mAb;抗ガングリオシドGD2mAb;抗ガングリオシドGM2mAb;抗GDF−8ヒトmAb(MYO−029);抗GM−CSF受容体mAb(CAM−3001);抗HepCmAb(HuMaxHepC);抗IFNαmAb(MEDI−545,MDX−1103);抗IGF1RmAb;抗IGF−1RmAb(HuMax−Inflam);抗IL12mAb(ABT−874);抗IL12/IL23mAb(CNTO1275);抗IL13mAb(CAT−354);抗IL2RamAb(HuMax−TAC);抗IL5受容体mAb;抗インテグリン受容体mAb(MDX−018,CNTO95);抗IP10潰瘍性大腸炎mAb(MDX−1100);抗LLY抗体;BMS−66513;抗マンノース受容体/hCGβmAb(MDX−1307);抗メソテリンdsFv−PE38接合体(CAT−5001);抗PD1mAb(MDX−1106(ONO−4538));抗PDGFRα抗体(IMC−3G3);抗TGFβmAb(GC−1008);抗ヒトTRAIL受容体−2mAb(HGS−ETR2);抗TWEAKmAb;抗VEGFR/Flt−1mAb;抗ZP3mAb(HuMax−ZP3);NVS抗体♯1;及び、NVS抗体♯2、である。
A)、アルファ−フェトタンパク質(AFP)、腫瘍壊死因子(TNF)、CTLA−4(細胞傷害性のT細胞関連抗原である)、Fc−γ−1受容体、HLA−DR10ベータ、HLA−DA抗原、L−セレクチン、呼吸系発疹ウイルス、ヒト免疫不全ウイルス(HIV)、B型肝炎ウイルス(HBV)、ミュータンス連鎖球菌、並びに、黄色ブドウ球菌、である。
Claims (33)
- 治療薬を注射するための装置であって、
前記治療薬を収容するシリンジを隠すカセットと、
自動注射器と、
を備え、
前記自動注射器が、針挿入薬押出駆動手段と、
ドアであって、開口位置において前記カセットを当該ドア内に挿入することを可能とし、閉鎖位置において前記カセットを前記挿入押出駆動手段と位置合わせさせる、ドアと、
を備えることを特徴とする装置。 - 前記カセットが、前記カセットの前記ドア内への正確な方向での挿入を補助する機械構造体を有することを特徴とする請求項1に記載の装置。
- 前記カセットが、前記カセットの前記ドア内への正確な方向での挿入を補助するための表示を有することを特徴とする請求項1または2に記載の装置。
- 前記カセットドアが、前記カセットのための挿入入口点を表示するための表示を有することを特徴とする請求項1から3のいずれか1項に記載の装置。
- シリンジ内に収容された治療薬を注射するための自動注射器であって、
前記シリンジが、カセット内に隠されており、
モータ駆動式針挿入治療薬押出駆動手段と、
ドアであって、開口位置において前記カセットを当該ドア内に挿入することを可能とし、閉鎖位置において前記カセットを前記挿入押出駆動手段と位置合わせさせる、ドアと、
を備えることを特徴とする自動注射器。 - 前記カセットドアが、前記カセットのための挿入入口点を表示するための表示を有することを特徴とする請求項5に記載の自動注射器。
- 前記モータ駆動式駆動手段が、挿入駆動モータと、ラックと、前記挿入駆動モータの回転運動を前記ラックに伝達させる挿入駆動ギアトレインと、を備える針挿入駆動部を有することを特徴とする請求項5または6に記載の自動注射器。
- 前記ギアトレインが、複数のギアを有することを特徴とする請求項7に記載の自動注射器。
- 前記ラックが、間隔をあけた第1及び第2突出部と、前記ギアトレインに係合するラック歯部と、を有することを特徴とする請求項7に記載の自動注射器。
- 針挿入サイクル中において、前記ラックの前記第1突出部が、前記カセット内で前記シリンダを担持する内側スリーブとラッチ解除し、前記内側スリーブを前記カセット内で前方に駆動させ、
針後退サイクル中において、前記ラックの前記第2突出部が、前記内側スリーブに係合して前記内側スリーブを前記カセット内で後方に引っ張ることを特徴とする請求項9に記載の自動注射器。 - 前記モータ駆動式駆動手段が、押出駆動モータと、プランジャロッドと、リードネジと、押出駆動ギアトレインと、を備える治療薬駆動押出駆動部を備え、
前記プランジャロッドが、前記リードネジ及び前記押出駆動ギアトレインを介して前記押出駆動モータによって駆動されることを特徴とする請求項5または6に記載の自動注射器。 - 前記プランジャロッドが、プッシャを有し、
前記リードネジが、螺合式ナットを有し、
前記ナットが、前記プランジャロッドを前記リードネジに結合し、
前記ナットが、前記プランジャロッドの前記プッシャを固定して保持していることを特徴とする請求項11に記載の自動注射器。 - 前記押出駆動ギアトレインが、前記押出駆動モータ及び前記リードネジに各別に結合された複数のギアを有し、これにより、前記押出駆動ギアトレインが前記押出駆動モータの回転運動を伝達させて前記リードネジを駆動させることを可能としていることを特徴とする請求項11に記載の自動注射器。
- 薬物押出サイクル中において、前記押出駆動モータが、前記リードネジを第1方向に回転させ、前記リードネジが、前記ナットを当該リードネジに沿って前方に移動させ、前記プランジャロッドを前記カセット内へ前方に駆動させ、前記シリンジを駆動させて前記治療薬を前記シリンジから放出させ、その後、前記薬物押出駆動モータが、前記リードネジを第2方向に回転させ、前記リードネジが、前記ナットを当該リードネジに沿って後方に移動させ、前記プランジャロッドを前記シリンジ及び前記カセットから引き抜くことを特徴とする請求項12に記載の自動注射器。
- 前記モータ駆動式針挿入治療薬押出駆動手段を制御して監視するためのマイクロプロセッサをさらに備え、これにより、針挿入、薬物押出及び針後退を自動化させていることを特徴とする請求項5に記載の自動注射器。
- 自動注射器と共に使用するためのカセットであって、
治療薬を収容するシリンジであって、当該シリンジの使用前後において当該カセット内に隠される、シリンジと、
当該カセットの前記自動注射器のドア内への正確な方向での挿入を補助する機械構造体と、
を備えることを特徴とするカセット。 - 当該カセットの前記ドア内への正確な方向での挿入を補助するための表示をさらに備えることを特徴とする請求項16に記載のカセット。
- 当該カセットを前記自動注射器内に設置したときに前記自動注射器の窓部と位置合わせされる両側の窓部をさらに備えることを特徴とする請求項16または17に記載のカセット。
- 当該カセット内での前記シリンジの進行を制限する硬質停止部をさらに備え、これにより、所望のあらかじめ設定した設計までの針侵入深さを確実にすることを特徴とする請求項16から18のいずれか1項に記載のカセット。
- シリンジ内に収容された治療薬を注射するための自動注射器であって、
前記シリンジが、カセット内で隠されており、
細長いハンドルセクションと、細長い前記ハンドルセクションに沿うカセット受容セクションと、を備えるケーシングを備え、
細長い前記ハンドルセクションが、軟質把持領域を有することを特徴とする自動注射器。 - 前記ケーシングの細長い前記ハンドルセクションの自由端部が、注射開始ボタンを有し、
前記注射開始ボタンが、親指を当該ボタン上に置くことを最適化するための凹凸部を有することを特徴とする請求項20に記載の自動注射器。 - 前記ケーシングの細長い前記ハンドルセクションの前記自由端部が、当該ケーシングの長手方向軸に対して傾けられており、親指を前記ボタン上に置くことをさらに最適化していることを特徴とする請求項21に記載の自動注射器。
- 前記注射開始ボタンが、当該自動注射器のオペレータまたはユーザに視覚信号を提供するために選択的に照明されており、前記視覚信号が、あらかじめ設定した動作事象を表示させることを特徴とする請求項21または22に記載の自動注射器。
- 前記軟質把持部分が、前記ケーシングの細長い前記ハンドルセクションの後側にあることを特徴とする請求項20から23のいずれか1項に記載の自動注射器。
- 前記ケーシングの前記カセット受容セクションが、当該カセット受容セクションの両側にある窓部と、前記カセットを当該自動注射器内に設置するためのカセットドアと、を有し、
前記カセット受容セクションの前記窓部が、前記カセットを当該自動注射器内に設置したときに前記カセットの窓部と位置合わせされることを特徴とする請求項20から24のいずれか1項に記載の自動注射器。 - 前記カセット窓部と前記カセット内に配置された前記シリンジとを照明するために前記ケーシング内に配置された発光部をさらに備え、オペレータまたはユーザが当該自動注射器の前記カセット及び前記ケーシングの前記窓部を通して注射サイクルを観測することを可能とすることを特徴とする請求項25に記載の自動注射器。
- シリンジ内に収容された治療薬を注射するための自動注射器であって、
前記シリンジが、カセット内に隠されており、
ハンドルセクションと、前記ハンドルセクションに沿うカセット受容セクションと、を有するケーシングを備え、
前記カセット受容セクションが、当該自動注射器を支持面で位置付けるためのベースを形成する平坦な端壁部を画成することを特徴とする自動注射器。 - 前記シリンジが、注射針と、前記注射針を被覆する針シールドと、を有し、
前記カセットが、前記注射針を被覆する前記針シールドを取り外すための針シールド取外器を有し、
前記端壁部が、前記カセットを当該自動注射器内に設置したときに前記針シールド取外器を前記カセットから取り外すことを可能とするアパーチャを有し、これにより、前記注射針を被覆する前記針シールドを取り外すことを特徴とする請求項27に記載の自動注射器。 - 前記端壁部の一部が、前記ケーシングの前記カセット受容セクションのカセットドアによって形成されており、
前記カセットドアが、前記カセットを当該自動注射器内に設置するためのものであり、
前記カセットドアが、前記カセットを当該自動注射器内に設置したときに前記針シールド取外器を前記カセットから取り外すことを可能とする前記アパーチャを有することを特徴とする請求項28に記載の自動注射器。 - 前記端壁部が、前記シールド取外器を前記カセットから取り外すときに照明する標的ライトをさらに有し、注射場所を視覚化して選択するときにオペレータまたはユーザを補助することを特徴とする請求項29に記載の自動注射器。
- 前記端壁部が皮膚に触れるまたは接触するか判断するための皮膚センサをさらに有し、皮膚接触を検出すると、音声の及び視覚のうちの少なくとも一方を表示することを特徴とする請求項27から30のいずれか1項に記載の自動注射器。
- 前記皮膚センサが、容量ベースのセンサであることを特徴とする請求項31に記載の自動注射器。
- 前記皮膚センサが、前記端壁部内に埋め込まれた2つの電極を有し、
前記電極が、皮膚接触を形成したか判断するためにマイクロプロセッサによって使用される容量信号を発生させることを特徴とする請求項32に記載の自動注射器。
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Families Citing this family (99)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2006259664A1 (en) | 2005-06-14 | 2006-12-28 | Amgen Inc. | Self-buffering protein formulations |
SI2240222T1 (en) | 2008-01-11 | 2018-08-31 | Ucb Biopharma Sprl | SYSTEMS FOR MEDICATION OF PATIENTS WITH REVOMATOID ARTS |
US8177749B2 (en) | 2008-05-20 | 2012-05-15 | Avant Medical Corp. | Cassette for a hidden injection needle |
EP2276527B1 (en) | 2008-05-20 | 2018-02-28 | Avant Medical Corp. | Autoinjector system |
US8052645B2 (en) | 2008-07-23 | 2011-11-08 | Avant Medical Corp. | System and method for an injection using a syringe needle |
US9393369B2 (en) | 2008-09-15 | 2016-07-19 | Medimop Medical Projects Ltd. | Stabilized pen injector |
US9427529B2 (en) | 2008-09-15 | 2016-08-30 | Medimop Medical Projects Ltd. | Safeguard mechanism for autoinjector needle |
CA2833748C (en) * | 2011-04-20 | 2019-07-16 | Amgen Inc. | Autoinjector apparatus |
WO2012164404A2 (en) | 2011-06-02 | 2012-12-06 | Ucb Pharma S.A. | Auto-injector |
AR087305A1 (es) * | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
US10493151B2 (en) | 2011-10-18 | 2019-12-03 | Coherus Biosciences, Inc. | Etanercept formulations stabilized with sodium chloride |
AU2012325937B2 (en) | 2011-10-21 | 2018-03-01 | Icu Medical, Inc. | Medical device update system |
USD898908S1 (en) | 2012-04-20 | 2020-10-13 | Amgen Inc. | Pharmaceutical product cassette for an injection device |
JP6479655B2 (ja) | 2012-07-05 | 2019-03-06 | ユーエヌエル ホールディングス エルエルシーUNL Holdings LLC | 注射可能カートリッジ用自動注射器及びその為の駆動制御機構 |
WO2014020000A1 (en) | 2012-07-30 | 2014-02-06 | Ucb Pharma S.A. | Auto-injector |
WO2014019999A1 (en) | 2012-07-30 | 2014-02-06 | Ucb Pharma S.A. | Auto-injector |
EP2879737B1 (en) | 2012-07-30 | 2018-09-12 | UCB Biopharma SPRL | Auto-injector |
WO2014019997A1 (en) | 2012-07-30 | 2014-02-06 | Ucb Pharma S.A. | Auto-injector |
CN104602736B (zh) | 2012-09-05 | 2018-04-20 | E3D农业合作协会有限公司 | 电子自动注射设备 |
GB201218913D0 (en) * | 2012-10-22 | 2012-12-05 | Ucb Pharma Sa | Auto-injector and drive unit therefor |
EP2938376A4 (en) | 2012-12-27 | 2017-01-25 | Kaleo, Inc. | Devices, systems and methods for locating and interacting with medicament delivery systems |
BR112015016201B1 (pt) * | 2013-01-16 | 2022-05-03 | Bayer Pharma Aktiengesellschaft | Dispositivo injetor de droga |
MX2015011453A (es) | 2013-03-08 | 2016-08-04 | Teva Pharma | Dispositivo inyector reutilizable para jeringa. |
US8652100B1 (en) * | 2013-03-08 | 2014-02-18 | Teva Pharmaceutical Industries, Ltd. | Re-useable injector device for syringe |
MX2015011451A (es) * | 2013-03-08 | 2016-06-10 | Teva Pharma | Dispositivo inyector reutilizable para jeringa. |
JP6768501B2 (ja) * | 2013-03-15 | 2020-10-14 | アムゲン・インコーポレーテッド | 薬物カセット、自動注入機、および自動注入機システム |
EP2968760B1 (en) * | 2013-03-15 | 2024-01-03 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
GB201313888D0 (en) * | 2013-08-02 | 2013-09-18 | Consort Medical Plc | Assembly for an autoinjector device |
GB201314381D0 (en) | 2013-08-12 | 2013-09-25 | Ucb Pharma Sa | Injector |
DK3459576T3 (da) | 2013-08-29 | 2023-05-30 | Sanofi Sa | Hætte til en medikamentbeholder |
EP3335751B1 (en) * | 2013-08-29 | 2020-12-30 | Sanofi | Safety device for a medicament container |
US20150066531A1 (en) | 2013-08-30 | 2015-03-05 | James D. Jacobson | System and method of monitoring and managing a remote infusion regimen |
WO2015048791A1 (en) * | 2013-09-30 | 2015-04-02 | Medimop Medical Projects Ltd. | Adhesive cover peeler and needle cover remover for autoinjector |
JP7086520B2 (ja) * | 2013-10-24 | 2022-06-20 | アムジエン・インコーポレーテツド | インジェクター及び組み立ての方法 |
GB2519974B (en) * | 2013-11-01 | 2017-06-14 | Consort Medical Plc | Medicament delivery device sub-assembly |
US9789254B2 (en) | 2014-01-27 | 2017-10-17 | Ucb Biopharma Sprl | Auto-injector |
EP3099351B1 (en) | 2014-01-27 | 2019-11-06 | UCB Biopharma SPRL | Auto-injector |
US9821123B2 (en) | 2014-01-27 | 2017-11-21 | Ucb Biopharma Sprl | Auto-injector |
FR3017956B1 (fr) * | 2014-02-21 | 2018-02-09 | Horiba Jobin Yvon Sas | Systeme et procede de transfert d'un echantillon fluidique dans une cellule fluidique |
KR20230037063A (ko) | 2014-06-03 | 2023-03-15 | 암겐 인코포레이티드 | 제어 가능한 약물 전달 시스템 및 사용 방법 |
WO2015189700A1 (en) | 2014-06-13 | 2015-12-17 | Aterica Inc. | System and device for management of medication delivery devices |
US9724470B2 (en) | 2014-06-16 | 2017-08-08 | Icu Medical, Inc. | System for monitoring and delivering medication to a patient and method of using the same to minimize the risks associated with automated therapy |
ES2834023T3 (es) | 2014-08-28 | 2021-06-16 | Unl Holdings Llc | Sistemas de sensores para dispositivos de administración de fármacos |
AU2015308659B2 (en) * | 2014-08-28 | 2020-07-02 | Unitract Syringe Pty Ltd | Skin sensors for drug delivery devices |
GB201416985D0 (en) | 2014-09-26 | 2014-11-12 | Ucb Biopharma Sprl And Bespak Europ Ltd | Housing part for an auto-injector |
US10293120B2 (en) | 2015-04-10 | 2019-05-21 | West Pharma. Services IL, Ltd. | Redundant injection device status indication |
WO2016210404A1 (en) * | 2015-06-26 | 2016-12-29 | Quio Technologies Llc. | Auto-injector device with interchangeable modules for dimensional and operational compatibility with a variety of diverse pre-filled cartridges |
JP2018523684A (ja) | 2015-08-18 | 2018-08-23 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドRegeneron Pharmaceuticals, Inc. | リポタンパク質アフェレーシスを受けている高脂血症の患者を治療するための抗pcsk9阻害抗体 |
US10155063B2 (en) | 2015-11-12 | 2018-12-18 | University Of Virginia Patent Foundation | Methods for vas-occlusive contraception and reversal thereof |
CN108290008B (zh) * | 2015-12-08 | 2024-03-08 | 贝克顿迪金森法国公司 | 用于医用注射器的带有半球形部分的帽 |
US10737036B2 (en) | 2015-12-08 | 2020-08-11 | Becton Dickinson France S.A.S. | Housing and cap for medical injector |
KR20180091078A (ko) * | 2015-12-08 | 2018-08-14 | 벡톤 디킨슨 프랑스 | 의료용 주입기용 캡 |
CN108290012B (zh) * | 2015-12-08 | 2022-04-08 | 贝克顿迪金森法国公司 | 用于医疗注射器的t形帽 |
WO2017100501A1 (en) * | 2015-12-09 | 2017-06-15 | Amgen Inc. | Auto-injector with signaling cap |
US10881801B2 (en) | 2015-12-24 | 2021-01-05 | Phc Holdings Corporation | Drug infusion device, cartridge adapter, and drug infusion system |
US10894129B2 (en) * | 2015-12-24 | 2021-01-19 | Phc Holdings Corporation | Drug injection device, cartridge adapter, and drug injection system |
JP7002465B2 (ja) | 2015-12-30 | 2022-01-20 | アセンディス ファーマ エー/エス | 充電器の安全性を有する自動注射器 |
NZ742526A (en) | 2015-12-30 | 2024-01-26 | Ascendis Pharma As | Auto injector with detection of used cartridge and associated method |
RS63450B1 (sr) | 2015-12-30 | 2022-08-31 | Ascendis Pharma As | Auto-injektor sa sistemom za zadržavanje kertridža |
DK3397318T3 (da) | 2015-12-30 | 2022-01-10 | Ascendis Pharma As | Autoinjektor med indstillelig luftskudsmekanisme |
ES2929568T3 (es) * | 2015-12-30 | 2022-11-30 | Ascendis Pharma As | Autoinyector con control de temperatura |
EP3429663B1 (en) * | 2016-03-15 | 2020-07-15 | Amgen Inc. | Reducing probability of glass breakage in drug delivery devices |
AU2017246285B2 (en) * | 2016-04-08 | 2021-09-23 | Icu Medical, Inc. | Control of a drug infusion device |
US11571516B2 (en) * | 2016-06-06 | 2023-02-07 | E3D Agricultural Cooperative Association | Multiple use computerized injector |
CH712753A2 (de) | 2016-07-28 | 2018-01-31 | Tecpharma Licensing Ag | Trennen einer Nadelschutzkappe von einem Produktbehälter und Verfahren zum Montieren einer Injektionsvorrichtung. |
SG11201903521XA (en) | 2016-10-21 | 2019-05-30 | Amgen Inc | Pharmaceutical formulations and methods of making the same |
WO2018096534A1 (en) | 2016-11-22 | 2018-05-31 | Sorrel Medical Ltd. | Apparatus for delivering a therapeutic substance |
EP3558420A4 (en) * | 2016-12-23 | 2020-05-27 | Kaleo, Inc. | DRUG DELIVERY DEVICE AND METHODS OF DELIVERY OF DRUGS TO INFANTS AND CHILDREN |
US10332623B2 (en) | 2017-01-17 | 2019-06-25 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and event detection |
KR102110292B1 (ko) * | 2017-01-20 | 2020-05-14 | 엘.쥐.피. 테크노로지 홀딩스 엘엘씨 | 자동 주사기 장치 |
ES2871812T3 (es) * | 2017-03-16 | 2021-11-02 | Novartis Ag | Dispositivo inyector |
KR20230056801A (ko) | 2017-05-23 | 2023-04-27 | 아센디스 파마 에이에스 | 가변 플런저 힘을 갖는 자동 인젝터 |
US11819666B2 (en) | 2017-05-30 | 2023-11-21 | West Pharma. Services IL, Ltd. | Modular drive train for wearable injector |
EP4241888A3 (en) | 2017-06-08 | 2023-12-27 | Becton, Dickinson and Company | Biological fluid separation device |
CA3064056A1 (en) | 2017-06-29 | 2019-01-03 | Steen Jensen | Auto injector with reconstitution handling support |
GB201718315D0 (en) | 2017-11-06 | 2017-12-20 | Owen Mumford Ltd | Auto-injector |
MX2020005066A (es) | 2017-11-16 | 2020-08-20 | Amgen Inc | Autoinyector con deteccion de detencion y punto final. |
US11400220B2 (en) | 2018-05-01 | 2022-08-02 | Portal Instruments, Inc. | Active injection guide |
WO2020018433A1 (en) | 2018-07-16 | 2020-01-23 | Kaleo, Inc. | Medicament delivery devices with wireless connectivity and compliance detection |
NZ772135A (en) | 2018-07-17 | 2022-11-25 | Icu Medical Inc | Systems and methods for facilitating clinical messaging in a network environment |
NZ771914A (en) | 2018-07-17 | 2023-04-28 | Icu Medical Inc | Updating infusion pump drug libraries and operational software in a networked environment |
EP3632487A1 (en) | 2018-10-05 | 2020-04-08 | Sorrel Medical Ltd. | Triggering sequence |
JP2022506078A (ja) | 2018-11-13 | 2022-01-17 | コントラライン,インコーポレイテッド | 生体材料を送達するためのシステムおよび方法 |
JP7119121B2 (ja) * | 2018-12-27 | 2022-08-16 | 株式会社ダイセル | 無針注射器 |
AU2020259327A1 (en) * | 2019-04-17 | 2021-09-16 | Amgen Inc. | Cassette for an autoinjector and related methods |
CA3148032A1 (en) * | 2019-08-01 | 2021-02-04 | Amgen Inc. | Drug delivery device with temperature measurement and related method |
AU2020363623A1 (en) * | 2019-10-08 | 2022-03-17 | Amgen Inc. | Cassette for an autoinjector and related methods |
DE102019220296A1 (de) * | 2019-12-19 | 2021-06-24 | Vetter Pharma-Fertigung GmbH & Co. KG | Injektionseinrichtung zum Injizieren einer pharmazeutischen Substanz, und Injektionsladeteil für eine solche Injektionseinrichtung |
EP4094790A4 (en) | 2020-01-23 | 2023-06-28 | PHC Holdings Corporation | Cassette, medicine injection device, and medicine injection system |
USD948039S1 (en) * | 2020-05-08 | 2022-04-05 | Vitagoods, LLC | Serum pen |
WO2022004876A1 (ja) * | 2020-07-02 | 2022-01-06 | ヤーマン株式会社 | 液体注入装置、及びそのシステムとカートリッジユニット |
WO2022056005A1 (en) * | 2020-09-09 | 2022-03-17 | Bard Access Systems, Inc. | Aspiration apparatus for intraosseous access system |
WO2022087325A1 (en) | 2020-10-23 | 2022-04-28 | Eli Lilly And Company | Medication delivery device including disposable and reusable portions |
WO2023287934A1 (en) * | 2021-07-16 | 2023-01-19 | Eli Lilly And Company | Methods and systems for selecting an injection site |
IL310641A (en) * | 2021-08-19 | 2024-04-01 | Lilly Co Eli | A device for transferring a therapeutic agent that includes disposable and reusable parts |
CN117794595A (zh) * | 2021-08-20 | 2024-03-29 | 伊莱利利公司 | 具有使用者输入装置的治疗剂输送装置 |
WO2023076712A1 (en) * | 2021-11-01 | 2023-05-04 | Becton, Dickinson And Company | Alarm indicator for drug delivery device |
EP4108277A1 (en) | 2022-07-22 | 2022-12-28 | Ypsomed AG | Syringe unit for a reusable injection device |
EP4275719A3 (en) | 2023-09-07 | 2024-04-24 | Ypsomed AG | Safety mechanism for an autoinjector |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009143255A1 (en) * | 2008-05-20 | 2009-11-26 | Avant Medical Corp. | Autoinjector system |
WO2010099850A1 (de) * | 2009-03-03 | 2010-09-10 | Dieter Hölzle Technik-Projekte GmbH | Injektionsvorrichtung mit injektionsvolumeneinstellung |
JP2016214237A (ja) * | 2010-06-28 | 2016-12-22 | ネステク ソシエテ アノニム | 低カロリー高タンパク質の栄養組成物及び該栄養組成物を用いる方法 |
Family Cites Families (664)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6241704B1 (en) * | 1901-11-22 | 2001-06-05 | Sims Deltec, Inc. | Drug pump systems and methods |
US2525398A (en) | 1948-02-02 | 1950-10-10 | Arthur L Collins | Hypodermic syringe holder and guide |
US2565081A (en) | 1948-09-15 | 1951-08-21 | Emma C Maynes | Device for operating hypodermic syringes |
US2701566A (en) | 1950-02-07 | 1955-02-08 | Becton Dickinson Co | Injection apparatus |
US2702547A (en) | 1950-02-27 | 1955-02-22 | Antonina S Glass | Motor-driven medical injection apparatus and cartridges therefor |
GB909898A (en) | 1958-04-17 | 1962-11-07 | Donald Travers Lewis | Improvements in or relating to a device for automatically effecting injections with a hypodermic syringe |
US3051173A (en) | 1960-05-12 | 1962-08-28 | Alvin P Johnson | Veterinary hypodermic syringe |
GB999506A (en) | 1960-11-02 | 1965-07-28 | Engis Ltd | Improvements in syringes for dispensing paste or the like |
US3203269A (en) | 1962-10-22 | 1965-08-31 | Lockheed Aircraft Corp | Telescoping screw sequencing device |
US3297210A (en) | 1964-12-28 | 1967-01-10 | Hewlett Packard Co | Dispensing apparatus |
US3623474A (en) | 1966-07-25 | 1971-11-30 | Medrad Inc | Angiographic injection equipment |
US3720211A (en) | 1971-08-18 | 1973-03-13 | G Kyrias | Automatic injection system |
US3964481A (en) | 1972-04-28 | 1976-06-22 | Albert Joseph Gourlandt | Automatic injection device |
US3859996A (en) | 1973-07-18 | 1975-01-14 | Mizzy Inc | Multi-dose injector |
FR2348709A1 (fr) | 1976-04-23 | 1977-11-18 | Pistor Michel | Procede de traitement mesotherapique et dispositif d'injection,formant micro-injecteur automatique,en comportant application |
US4273122A (en) | 1976-11-12 | 1981-06-16 | Whitney Douglass G | Self contained powered injection system |
FR2390175A2 (fr) | 1977-05-10 | 1978-12-08 | Endoscoptic Sarl | Procede de traitement mesotherapique et dispositif d'injection formant micro-injecteur automatique, en comportant application |
DE2812729A1 (de) * | 1978-03-23 | 1979-09-27 | Michael Becker | Injektionsvorrichtung zur intramuskulaeren einspritzung, vornehmlich von insulin |
US4198975A (en) | 1978-10-06 | 1980-04-22 | Haller J Gilbert | Self-injecting hypodermic syringe device |
DE2929425A1 (de) | 1979-07-20 | 1981-02-12 | Lothar Kling | Vorrichtung fuer injektionsspritzen zur intramuskulaeren und subentanen injektion |
DE8006721U1 (de) | 1980-03-12 | 1981-09-03 | Becker, Michael, 5020 Frechen | Injektionsvorrichtung zur intramuskulaeren einspritzung eines medikamentes, insbesondere von insulin |
US4276879A (en) | 1980-03-14 | 1981-07-07 | Vineland Laboratories, Inc. | Automatic injection apparatus |
US4421107A (en) | 1980-10-15 | 1983-12-20 | Estes Roger Q | Surgical retractor elements and assembly |
SE436687B (sv) | 1981-12-14 | 1985-01-21 | Anders Blomberg | Injektionsanordning |
IL65031A (en) | 1982-02-16 | 1983-07-31 | Abic Ltd | Automatic injection apparatus |
US4465478A (en) | 1982-10-14 | 1984-08-14 | Collagen Corporation | Syringe force amplification device |
US4493704A (en) | 1982-11-29 | 1985-01-15 | Oximetrix, Inc. | Portable fluid infusion apparatus |
US4504263A (en) | 1982-12-22 | 1985-03-12 | Valleylab, Inc. | Flow rate monitor with optical sensing chamber |
US4502488A (en) | 1983-01-13 | 1985-03-05 | Allied Corporation | Injection system |
DE3468173D1 (en) | 1983-09-07 | 1988-02-04 | Disetronic Ag | Portable infusion apparatus |
US4758227A (en) | 1983-09-24 | 1988-07-19 | Morf Inc. | Bird injection system |
KR850004274A (ko) | 1983-12-13 | 1985-07-11 | 원본미기재 | 에리트로포이에틴의 제조방법 |
US4703008A (en) | 1983-12-13 | 1987-10-27 | Kiren-Amgen, Inc. | DNA sequences encoding erythropoietin |
NZ210501A (en) | 1983-12-13 | 1991-08-27 | Kirin Amgen Inc | Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence |
US4685903A (en) | 1984-01-06 | 1987-08-11 | Pacesetter Infusion, Ltd. | External infusion pump apparatus |
US4613328A (en) | 1984-10-22 | 1986-09-23 | Cecil Boyd | Bio-medical injector apparatus |
US4573975A (en) * | 1985-01-04 | 1986-03-04 | Frist Brian S | Protective shield for needle receiver |
FR2581548B1 (fr) | 1985-05-09 | 1990-07-20 | Villette Alain | Dispositif d'injection intraosseuse de produits biocompatibles |
US4689042A (en) | 1985-05-20 | 1987-08-25 | Survival Technology, Inc. | Automatic medicament ingredient mixing and injecting apparatus |
US4838857A (en) | 1985-05-29 | 1989-06-13 | Becton, Dickinson And Company | Medical infusion device |
US4636201A (en) | 1985-11-01 | 1987-01-13 | American Hospital Supply Corporation | Hypodermic syringe having a protective sheath cover |
US4680027A (en) | 1985-12-12 | 1987-07-14 | Injet Medical Products, Inc. | Needleless hypodermic injection device |
FR2592307A1 (fr) | 1985-12-30 | 1987-07-03 | Guez Bernard | Dispositif commande par microprocesseur pour administrer ou prelever des produits ainsi que des micro-courants. |
FR2594341B1 (fr) | 1986-02-14 | 1990-08-10 | Charton Jean Pierre | Appareil injecteur pour la pratique de la mesotherapie |
WO1987007160A1 (en) | 1986-05-29 | 1987-12-03 | Baxter Travenol Laboratories, Inc. | Drug delivery apparatus with piston injection site |
US5180371A (en) | 1986-05-30 | 1993-01-19 | Spintech, Inc. | Hypodermic anesthetic injection apparatus and method |
EP0310629A1 (en) | 1986-08-05 | 1989-04-12 | University of Wales College of Medicine | Proximity detector |
DE3638984C3 (de) | 1986-11-14 | 1993-11-18 | Haselmeier Wilhelm Fa | Injektionsgerät |
US5569190A (en) | 1987-06-08 | 1996-10-29 | D'antonio; Nicholas F. | Hypodermic fluid dispenser |
US6056716A (en) | 1987-06-08 | 2000-05-02 | D'antonio Consultants International Inc. | Hypodermic fluid dispenser |
US5080648A (en) | 1987-06-08 | 1992-01-14 | Antonio Nicholas F D | Hypodermic fluid dispenser |
US4877034A (en) | 1987-06-18 | 1989-10-31 | Smith & Nephew, Inc. | Method and device for detection of tissue infiltration |
ATA228987A (de) * | 1987-09-09 | 1993-07-15 | Pickhard Ewald | Injektionsvorrichtung mit einer verformbaren ampulle |
FR2622457A1 (fr) | 1987-11-03 | 1989-05-05 | Piccinali Eric | Injecteur mesotherapique a microprocesseur |
US4919596A (en) | 1987-12-04 | 1990-04-24 | Pacesetter Infusion, Ltd. | Fluid delivery control and monitoring apparatus for a medication infusion system |
CH675078A5 (ja) | 1988-01-22 | 1990-08-31 | Nosta Ag | |
US5013299A (en) | 1988-03-04 | 1991-05-07 | Clark William C | Syringe resheathing device |
JPH028157A (ja) | 1988-06-28 | 1990-01-11 | Matsushita Electric Ind Co Ltd | コード巻取装置 |
IL87559A (en) | 1988-08-25 | 1993-06-10 | Amir Avni Carmiel And Menachem | Injection apparatus for veterinary use |
US4902279A (en) | 1988-10-05 | 1990-02-20 | Autoject Systems Inc. | Liquid medicament safety injector |
US4929237A (en) | 1988-11-07 | 1990-05-29 | David Medway | Hypodermic needle protection device |
US5024616A (en) | 1988-11-15 | 1991-06-18 | International Medication Systems, Limited | Disposable sheath for hypodermic cannula used with a syringe |
FR2639234B1 (fr) | 1988-11-21 | 1994-05-06 | Denance Raymond | Dispositif d'injection a usage medical et veterinaire dont la mire stabilisatrice est a usage unique et actionne un moyen faisant office de clapet au niveau de l'aiguille |
US5569236A (en) | 1989-06-16 | 1996-10-29 | Science Incorporated | Fluid delivery apparatus |
US5085641A (en) | 1989-07-17 | 1992-02-04 | Survival Technology, Inc. | Conveniently carried frequent use auto-injector with improved cap structure |
AU646822B2 (en) | 1989-10-13 | 1994-03-10 | Kirin-Amgen Inc. | Erythropoietin isoforms |
US5856298A (en) | 1989-10-13 | 1999-01-05 | Amgen Inc. | Erythropoietin isoforms |
US5272064A (en) | 1989-12-19 | 1993-12-21 | Amgen Inc. | DNA molecules encoding platelet-derived growth factor B chain analogs and method for expression thereof |
US5149792A (en) | 1989-12-19 | 1992-09-22 | Amgen Inc. | Platelet-derived growth factor B chain analogs |
US4986818A (en) | 1990-03-30 | 1991-01-22 | Becton, Dickinson And Company | Syringe assembly |
US5092843A (en) | 1990-04-12 | 1992-03-03 | Survival Technology, Inc. | Dispersion multichamber auto-injector |
USD334233S (en) | 1990-07-08 | 1993-03-23 | Baxter International Inc. | Cannula hub body with viewing lens |
US5114404A (en) | 1990-07-24 | 1992-05-19 | Paxton Gerald R | Multifunctional retractable needle type general purpose disabling syringe having enhanced safety features and related method of operation |
WO1992006725A1 (en) | 1990-10-12 | 1992-04-30 | Habley Medical Technology Corporation | Disposal module with sleeve for prefilled cartridges |
US5352196A (en) | 1990-11-19 | 1994-10-04 | Habley Medical Technology Corporation | Mixing vial |
US5114411A (en) | 1990-11-19 | 1992-05-19 | Habley Medical Technology Corporation | Multi-chamber vial |
US5354287A (en) | 1991-01-16 | 1994-10-11 | Senetek Plc | Injector for delivering fluid to internal target tissue |
US5098400A (en) | 1991-02-14 | 1992-03-24 | Sherwood Medical Company | Needle shield |
US5176643A (en) | 1991-04-29 | 1993-01-05 | George C. Kramer | System and method for rapid vascular drug delivery |
US5868711A (en) | 1991-04-29 | 1999-02-09 | Board Of Regents, The University Of Texas System | Implantable intraosseous device for rapid vascular access |
US5451210A (en) | 1991-04-29 | 1995-09-19 | Lifequest Medical, Inc. | System and method for rapid vascular drug delivery |
US5300031A (en) | 1991-06-07 | 1994-04-05 | Liebel-Flarsheim Company | Apparatus for injecting fluid into animals and disposable front loadable syringe therefor |
DE59202070D1 (de) | 1991-07-24 | 1995-06-08 | Medico Dev Investment Co | Injektor. |
US5200604A (en) | 1991-08-07 | 1993-04-06 | Laser Engineering, Inc. | Handpiece optical proximity detector for disabling surgical laser beam |
BR9107315A (pt) | 1991-08-07 | 1995-01-03 | Sterling Winthrop Inc | Seringa de segurança, conjunto de seringas, unidade de invólucro oco para alojar uma unidade cartucho-agulha e conjunto unitáro moldado de unidades de invólucro |
US5221268A (en) | 1991-12-06 | 1993-06-22 | Block Medical, Inc. | Multiple dose control apparatus |
CA2127359C (en) | 1992-01-07 | 2006-05-30 | John Glyndwr Wilmot | Automatic injectors |
IL101720A (en) | 1992-04-29 | 1998-09-24 | Mali Tech Ltd | Needle for syringe or the like |
US6290683B1 (en) | 1992-04-29 | 2001-09-18 | Mali-Tech Ltd. | Skin piercing needle assembly |
US5382785A (en) | 1992-05-04 | 1995-01-17 | Diolase Corporation | Laser beam delivery path and target proximity sensor |
US5300041A (en) | 1992-06-01 | 1994-04-05 | Habley Medical Technology Corporation | Dose setting and repeating syringe |
US5269766A (en) | 1992-06-09 | 1993-12-14 | Habley Medical Technology Corporation | Dental syringe having an automatically retractable medication carpule and needle cannula |
FR2693112B1 (fr) | 1992-07-01 | 1994-09-02 | Raymond Denance | Dispositif électromécanique d'injection à usage médical et vétérinaire actionné par une gâchette. |
US5271413A (en) | 1992-07-22 | 1993-12-21 | Dalamagas Photios P | Method to sense the tissue for injection from a hypodermic needle |
GB9219849D0 (en) | 1992-09-19 | 1992-10-28 | Hypoguard Uk Ltd | Device |
WO1994006690A1 (en) | 1992-09-21 | 1994-03-31 | Habley Medical Technology Corporation | Device and method for containing an ampule and transferring liquid within the ampule to a container |
IL107038A (en) | 1992-10-05 | 1997-04-15 | Senetek Plc | Medicament injectors and methods for injection using same |
US5569212A (en) | 1994-07-22 | 1996-10-29 | Raya Systems, Inc. | Apparatus for electrically determining injection doses in syringes |
JPH08505543A (ja) | 1992-11-19 | 1996-06-18 | テブロ ソシエテ アノニム | 予充填注射器用の使い捨て自動注射装置 |
FR2701211B1 (fr) | 1993-02-08 | 1995-05-24 | Aguettant Lab | Instrument doseur, notamment d'injection |
WO1994021324A1 (en) | 1993-03-23 | 1994-09-29 | Focal, Inc. | Apparatus and method for local application of polymeric material to tissue |
US5584815A (en) | 1993-04-02 | 1996-12-17 | Eli Lilly And Company | Multi-cartridge medication injection device |
ZA941881B (en) * | 1993-04-02 | 1995-09-18 | Lilly Co Eli | Manifold medication injection apparatus and method |
US5746714A (en) | 1993-04-05 | 1998-05-05 | P.A.T.H. | Air powered needleless hypodermic injector |
US5366118A (en) | 1993-04-30 | 1994-11-22 | Guardian Personal Security Products, Inc. | Dispenser for aerosol device |
GB9309151D0 (en) | 1993-05-04 | 1993-06-16 | Zeneca Ltd | Syringes and syringe pumps |
US5540664A (en) | 1993-05-27 | 1996-07-30 | Washington Biotech Corporation | Reloadable automatic or manual emergency injection system |
US5425715A (en) | 1993-08-05 | 1995-06-20 | Survival Technology, Inc. | Reloadable injector |
IL192290A0 (en) | 1993-08-17 | 2008-12-29 | Kirin Amgen Inc | Erythropoietin analogs |
US5431627A (en) | 1993-11-12 | 1995-07-11 | Abbott Laboratories | Cassette identification system for use with a multi-program drug infusion pump |
US5830851A (en) | 1993-11-19 | 1998-11-03 | Affymax Technologies N.V. | Methods of administering peptides that bind to the erythropoietin receptor |
US5773569A (en) | 1993-11-19 | 1998-06-30 | Affymax Technologies N.V. | Compounds and peptides that bind to the erythropoietin receptor |
US5531697A (en) * | 1994-04-15 | 1996-07-02 | Sims Deltec, Inc. | Systems and methods for cassette identification for drug pumps |
CA2129284C (en) | 1993-11-24 | 1999-03-09 | Kenneth J. Niehoff | Controlling plunger drives for fluid injection in animals |
US5354286A (en) | 1993-12-07 | 1994-10-11 | Survival Technology, Inc. | Injection device having polyparaxylylene coated container |
US5478316A (en) | 1994-02-02 | 1995-12-26 | Becton, Dickinson And Company | Automatic self-injection device |
US5514097A (en) | 1994-02-14 | 1996-05-07 | Genentech, Inc. | Self administered injection pen apparatus and method |
DE69502357T2 (de) | 1994-02-14 | 1999-01-07 | Sanofi Sa | Injektionsmodul für eine spritze |
FR2716375B3 (fr) | 1994-02-23 | 1996-05-24 | Alain Villette | Injecteur médical. |
US5536249A (en) | 1994-03-09 | 1996-07-16 | Visionary Medical Products, Inc. | Pen-type injector with a microprocessor and blood characteristic monitor |
WO1995025555A1 (en) | 1994-03-18 | 1995-09-28 | Vitajet Corporation | Air-powered needleless hypodermic injector |
AU1994295A (en) | 1994-05-16 | 1995-12-05 | Washington Biotech Corporation | Modular automatic or manual emergency medicine injection system |
DK0762904T3 (da) | 1994-05-30 | 2002-10-28 | B D Medico S A R L | Injektionsudstyr |
GB9412301D0 (en) | 1994-06-17 | 1994-08-10 | Safe T Ltd | Hollow-needle drugs etc applicators |
US5885574A (en) | 1994-07-26 | 1999-03-23 | Amgen Inc. | Antibodies which activate an erythropoietin receptor |
IL114909A (en) | 1994-08-12 | 1999-10-28 | Immunomedics Inc | Immunoconjugates and humanized antibodies specific for b-cell lymphoma and leukemia cells |
US5569197A (en) | 1994-12-21 | 1996-10-29 | Schneider (Usa) Inc | Drug delivery guidewire |
US5599302A (en) | 1995-01-09 | 1997-02-04 | Medi-Ject Corporation | Medical injection system and method, gas spring thereof and launching device using gas spring |
US5690618A (en) | 1995-02-22 | 1997-11-25 | Mark Timothy Smith | Electronic syringe |
GB9503969D0 (en) | 1995-02-28 | 1995-04-19 | Sams Bernard | Incrementing mechanism |
US5647853A (en) | 1995-03-03 | 1997-07-15 | Minimed Inc. | Rapid response occlusion detector for a medication infusion pump |
ATE279517T1 (de) | 1995-03-23 | 2004-10-15 | Immunex Corp | Il-17 receptor |
FR2733155B1 (fr) | 1995-04-18 | 1997-09-19 | Tebro | Auto-injecteur rechargeable |
US6099502A (en) | 1995-04-20 | 2000-08-08 | Acist Medical Systems, Inc. | Dual port syringe |
PL181217B1 (pl) | 1995-06-02 | 2001-06-29 | Novo Nordisk As | Strzykawka |
US5686292A (en) | 1995-06-02 | 1997-11-11 | Genentech, Inc. | Hepatocyte growth factor receptor antagonist antibodies and uses thereof |
US5767078A (en) | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
CA2151407A1 (en) | 1995-06-09 | 1996-12-10 | Duncan Newman | Injection device |
US5647851A (en) | 1995-06-12 | 1997-07-15 | Pokras; Norman M. | Method and apparatus for vibrating an injection device |
CA2229940A1 (en) | 1995-08-22 | 1997-03-06 | Michael J. Botich | Pre-filled retractable needle injection ampoules |
US5779675A (en) * | 1995-08-25 | 1998-07-14 | Medrad, Inc. | Front load pressure jacket system with syringe holder |
DE19536566C1 (de) | 1995-10-02 | 1997-02-06 | Arburg Gmbh & Co | Verfahren zur Regelung des Werkzeuginnendrucks an einer zyklisch arbeitenden Maschine |
US6283951B1 (en) | 1996-10-11 | 2001-09-04 | Transvascular, Inc. | Systems and methods for delivering drugs to selected locations within the body |
EP0956059A1 (en) | 1996-02-29 | 1999-11-17 | Medi-Ject Corporation | Nozzle assembly with adjustable plunger travel gap |
GB9606829D0 (en) | 1996-03-30 | 1996-06-05 | Jeffrey Peter | Supplying materials etc |
ES2121536B1 (es) | 1996-07-15 | 1999-05-16 | Arjona Perez Mariano | Aparato automatico para la aplicacion de inyecciones. |
US5843036A (en) | 1996-08-23 | 1998-12-01 | Becton Dickinson And Company | Non-dosing cartridge for an injection device |
US5709662A (en) | 1996-08-23 | 1998-01-20 | Becton Dickinson France, S.A. | Cartridge for an injection device |
CN1246071A (zh) | 1996-09-03 | 2000-03-01 | Mdc投资控股公司 | 预充填可缩进针注射器 |
CA2259560C (en) * | 1996-10-09 | 2005-07-05 | Equidyne Systems, Inc. | Hypodermic jet injector |
AU5251198A (en) | 1996-11-15 | 1998-06-03 | Beloit Technologies, Inc. | Dual feed flow system apparatus for a paper web coater |
AU5309798A (en) | 1996-12-20 | 1998-07-17 | Novo Nordisk A/S | Needle insertion mechanism |
US6203530B1 (en) | 1997-01-28 | 2001-03-20 | Pos-T-Vac, Inc. | Auto-injection device |
US6171283B1 (en) | 1997-03-10 | 2001-01-09 | Safety Syringes, Inc. | Disposable self-shielding unit dose syringe guard |
US6159184A (en) | 1997-03-10 | 2000-12-12 | Safety Syringes, Inc. | Disposable self-shielding unit dose syringe guard |
US5928158A (en) | 1997-03-25 | 1999-07-27 | Aristides; Arellano | Medical instrument with nerve sensor |
DE19717107B4 (de) | 1997-04-23 | 2005-06-23 | Disetronic Licensing Ag | System aus Behältnis und Antriebsvorrichtung für einen Kolben, der in dem ein Medikamentfluid enthaltenden Behältnis gehalten ist |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
US5968063A (en) | 1997-05-14 | 1999-10-19 | Jennifer Chu | Intramuscular stimulation therapy facilitating device and method |
US5993412A (en) | 1997-05-19 | 1999-11-30 | Bioject, Inc. | Injection apparatus |
US5911703A (en) | 1997-05-22 | 1999-06-15 | Avant Drug Delivery Systems, Inc. | Two-stage fluid medicament jet injector |
WO1999003887A1 (en) | 1997-07-14 | 1999-01-28 | Bolder Biotechnology, Inc. | Derivatives of growth hormone and related proteins |
US6753165B1 (en) | 1999-01-14 | 2004-06-22 | Bolder Biotechnology, Inc. | Methods for making proteins containing free cysteine residues |
US6569127B1 (en) * | 1997-07-18 | 2003-05-27 | Liebel-Flarsheim Company | Adapter and syringe for front-loading medical fluid injector |
KR100641969B1 (ko) | 1997-07-23 | 2006-11-06 | 로셰 디아그노스틱스 게엠베하 | 내인성 유전자 활성화에 의한 에리트로포이에틴의제조방법 |
GB9716065D0 (en) | 1997-07-31 | 1997-10-01 | Owen Mumford Ltd | Improvements relating to injection devices |
US6171276B1 (en) | 1997-08-06 | 2001-01-09 | Pharmacia & Upjohn Ab | Automated delivery device and method for its operation |
US5921966A (en) | 1997-08-11 | 1999-07-13 | Becton Dickinson And Company | Medication delivery pen having an improved clutch assembly |
DK1003580T3 (da) | 1997-08-21 | 2004-02-23 | Ares Trading Sa | Injektionsanordning |
US6149626A (en) | 1997-10-03 | 2000-11-21 | Bachynsky; Nicholas | Automatic injecting syringe apparatus |
US6019747A (en) | 1997-10-21 | 2000-02-01 | I-Flow Corporation | Spring-actuated infusion syringe |
CA2223659A1 (fr) | 1997-12-03 | 1999-06-03 | Alain Villette | Injecteur medical |
IL136714A0 (en) | 1997-12-16 | 2001-06-14 | Meridian Medical Technologies | Automatic injector for administrating a medicament |
AU736958B2 (en) | 1998-01-12 | 2001-08-09 | Claus Mollsoe | An injector |
DE29801168U1 (de) | 1998-01-24 | 1999-08-12 | Medico Dev Investment Co | Injektionsgerät |
GB9803084D0 (en) | 1998-02-14 | 1998-04-08 | Owen Mumford Ltd | Improvements relating to medical injection devices |
US6090082A (en) | 1998-02-23 | 2000-07-18 | Becton, Dickinson And Company | Vial retainer interface to a medication delivery pen |
US6183442B1 (en) | 1998-03-02 | 2001-02-06 | Board Of Regents Of The University Of Texas System | Tissue penetrating device and methods for using same |
US6030086A (en) | 1998-03-02 | 2000-02-29 | Becton, Dickinson And Company | Flash tube reflector with arc guide |
US6104941A (en) | 1998-03-26 | 2000-08-15 | Ge Marquette Medical Systems, Inc. | Physiological sensor |
JPH11276583A (ja) | 1998-03-31 | 1999-10-12 | Miyota Kk | 注射器及び注射液充填用カートリッジ |
US6616639B2 (en) * | 1998-04-17 | 2003-09-09 | Becton, Dickinson And Company | Safety shield system for syringes |
US6310078B1 (en) | 1998-04-20 | 2001-10-30 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted amino acids as erythropoietin mimetics |
DE19819409A1 (de) | 1998-04-30 | 1999-11-11 | Schering Ag | Injektionsvorrichtung |
JP3427171B2 (ja) | 1998-05-01 | 2003-07-14 | 日創電機株式会社 | 成形機 |
DE19822031C2 (de) | 1998-05-15 | 2000-03-23 | Disetronic Licensing Ag | Autoinjektionsgerät |
US20050181482A1 (en) | 2004-02-12 | 2005-08-18 | Meade Harry M. | Method for the production of an erythropoietin analog-human IgG fusion proteins in transgenic mammal milk |
DK1088084T3 (da) | 1998-06-15 | 2007-01-29 | Gtc Biotherapeutics Inc | Erythropoietin analog-humant serumalbumin fusionsprotein |
US6743202B2 (en) | 1998-06-15 | 2004-06-01 | Medrad, Inc. | Encoding of syringe information |
DE69913344T2 (de) | 1998-06-15 | 2004-10-14 | Medrad, Inc. | Kodierung von spritzeninformation |
DE69911965T2 (de) | 1998-07-08 | 2004-08-12 | Novo Nordisk A/S | Medizinisches abgabesystem sowie einsatzeinheit dafür |
US6428528B2 (en) | 1998-08-11 | 2002-08-06 | Antares Pharma, Inc. | Needle assisted jet injector |
GB9817662D0 (en) | 1998-08-13 | 1998-10-07 | Crocker Peter J | Substance delivery |
US5993423A (en) | 1998-08-18 | 1999-11-30 | Choi; Soo Bong | Portable automatic syringe device and injection needle unit thereof |
AU773891C (en) | 1998-10-23 | 2005-02-17 | Kirin-Amgen Inc. | Dimeric thrombopoietin peptide mimetics binding to MP1 receptor and having thrombopoietic activity |
DK1123313T3 (da) | 1998-10-23 | 2007-06-18 | Amgen Inc | Fremgangsmåder og sammensætninger til forebyggelse og behandling af anæmi |
SE9803662D0 (sv) | 1998-10-26 | 1998-10-26 | Pharmacia & Upjohn Ab | Autoinjector |
US6248093B1 (en) | 1998-10-29 | 2001-06-19 | Minimed Inc. | Compact pump drive system |
US6800071B1 (en) | 1998-10-29 | 2004-10-05 | Medtronic Minimed, Inc. | Fluid reservoir piston |
CA2349382C (en) | 1998-10-30 | 2007-12-11 | Immunex Corporation | Method and apparatus for operating a syringe and vial for injections |
PT2261335T (pt) | 1998-11-27 | 2017-09-08 | Ucb Pharma Sa | Composições e métodos para aumentar a mineralização óssea |
US6540672B1 (en) | 1998-12-09 | 2003-04-01 | Novo Nordisk A/S | Medical system and a method of controlling the system for use by a patient for medical self treatment |
EP1006184A1 (en) | 1998-12-03 | 2000-06-07 | F. Hoffmann-La Roche Ag | IGF-1 receptor interacting proteins (IIPs) genes coding therefor and uses thereof |
US6077055A (en) * | 1998-12-03 | 2000-06-20 | Sims Deltec, Inc. | Pump system including cassette sensor and occlusion sensor |
US6238335B1 (en) | 1998-12-11 | 2001-05-29 | Enteric Medical Technologies, Inc. | Method for treating gastroesophageal reflux disease and apparatus for use therewith |
US20010018937A1 (en) | 1998-12-28 | 2001-09-06 | Shigeru Nemoto | Method and device for pre-filling a syringe with a contrast agent |
US6645177B1 (en) | 1999-02-09 | 2003-11-11 | Alaris Medical Systems, Inc. | Directly engaged syringe driver system |
JP2000237309A (ja) | 1999-02-25 | 2000-09-05 | Ichiro Takai | インスリン注入経歴把握装置 |
EP1169352A4 (en) | 1999-04-14 | 2005-05-04 | Smithkline Beecham Corp | ANTIBODY AGAINST THE ERYTHROPOIETIN RECEPTOR |
US7297680B2 (en) | 1999-04-15 | 2007-11-20 | Crucell Holland B.V. | Compositions of erythropoietin isoforms comprising Lewis-X structures and high sialic acid content |
SE9901366D0 (sv) | 1999-04-16 | 1999-04-16 | Pharmacia & Upjohn Ab | Injector device and method for its operation |
SE9901736D0 (sv) | 1999-05-12 | 1999-05-12 | Pharmacia & Upjohn Ab | Injectino device and method for ITS operation |
US6752787B1 (en) | 1999-06-08 | 2004-06-22 | Medtronic Minimed, Inc., | Cost-sensitive application infusion device |
US6270481B1 (en) | 1999-06-16 | 2001-08-07 | Breg, Inc. | Patient-controlled medication delivery system |
EP1107806A1 (en) | 1999-06-30 | 2001-06-20 | Baxter International Inc. | Syringe for transfer of medication from a prefilled medication container |
CZ299516B6 (cs) | 1999-07-02 | 2008-08-20 | F. Hoffmann-La Roche Ag | Konjugát erythropoetinového glykoproteinu, zpusobjeho výroby a použití a farmaceutická kompozice sjeho obsahem |
WO2001008727A1 (en) | 1999-07-30 | 2001-02-08 | Medrad, Inc. | Injector systems and syringe adapters for use therewith |
US6213987B1 (en) * | 1999-08-02 | 2001-04-10 | Michael N. Hirsch | Shroud for a used hypodermic syringe needle |
US6318647B1 (en) | 1999-08-18 | 2001-11-20 | The Procter & Gamble Company | Disposable cartridge for use in a hand-held electrostatic sprayer apparatus |
US6520928B1 (en) | 1999-08-19 | 2003-02-18 | Alceu Meibach Rosa Junior | Medical liquid injection system and method |
JP2003508164A (ja) | 1999-09-07 | 2003-03-04 | コンピューター・コントロールド・シリンジ・インコーポレーテッド | 引っ込み可能な針装置 |
JP2003510135A (ja) | 1999-09-29 | 2003-03-18 | スターリング メディヴェイションズ インコーポレイテッド | 再使用可能な医薬注入装置 |
US6569123B2 (en) | 1999-10-14 | 2003-05-27 | Becton, Dickinson And Company | Prefillable intradermal injector |
EP1228214A2 (en) | 1999-11-12 | 2002-08-07 | MERCK PATENT GmbH | Erythropoietin forms with improved properties |
US20050202538A1 (en) | 1999-11-12 | 2005-09-15 | Merck Patent Gmbh | Fc-erythropoietin fusion protein with improved pharmacokinetics |
DK1233800T3 (da) | 1999-11-24 | 2007-10-01 | Medrad Inc | Forfra ladet medicinsk injektor og spröjte |
US6520930B2 (en) | 1999-11-24 | 2003-02-18 | Medrad, Inc. | Injectors, injector systems and injector control |
AU1816701A (en) | 1999-12-07 | 2001-06-18 | Medrad, Inc. | Syringes, syringe tubing and fluid transfer systems |
US6652489B2 (en) | 2000-02-07 | 2003-11-25 | Medrad, Inc. | Front-loading medical injector and syringes, syringe interfaces, syringe adapters and syringe plungers for use therewith |
AUPQ599700A0 (en) | 2000-03-03 | 2000-03-23 | Super Internet Site System Pty Ltd | On-line geographical directory |
US6485465B2 (en) | 2000-03-29 | 2002-11-26 | Medtronic Minimed, Inc. | Methods, apparatuses, and uses for infusion pump fluid pressure and force detection |
US6586398B1 (en) | 2000-04-07 | 2003-07-01 | Amgen, Inc. | Chemically modified novel erythropoietin stimulating protein compositions and methods |
US6190361B1 (en) | 2000-04-18 | 2001-02-20 | Gettig Technologies, Inc. | Selectively lockable needle guard |
EP1961425B1 (en) | 2000-04-21 | 2017-07-19 | Amgen Inc. | Methods and erythropoeitin analogs for the prevention and treatment of anemia |
US6756480B2 (en) | 2000-04-27 | 2004-06-29 | Amgen Inc. | Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein |
GB0012165D0 (en) | 2000-05-20 | 2000-07-12 | Team Consulting Ltd | Portable device with consistent power output |
US6673048B1 (en) | 2000-05-24 | 2004-01-06 | Acist Medical Systems, Inc. | Pressure sleeve assembly |
US6406456B1 (en) | 2000-06-08 | 2002-06-18 | Avant Drug Delivery Systems, Inc. | Jet injector |
US6645169B1 (en) | 2000-06-08 | 2003-11-11 | Avant Drug Delivery Systems, Inc. | Air-in-tip jet injector |
JP2001357132A (ja) | 2000-06-12 | 2001-12-26 | Iwami Kaihatsu Kk | 医薬品の投与システム及び投与方法 |
EP1908487A1 (en) | 2000-07-20 | 2008-04-09 | ACIST Medical Systems, Inc. | Syringe plunger locking mechanism |
JP3794252B2 (ja) | 2000-07-26 | 2006-07-05 | 東芝機械株式会社 | 電動式射出成形機および電動式射出成形機の射出制御方法 |
US6986760B2 (en) | 2000-08-02 | 2006-01-17 | Becton, Dickinson And Company | Pen needle and safety shield system |
EP1309366B1 (en) | 2000-08-10 | 2007-02-21 | Novo Nordisk A/S | Medication delivery device comprising a support for a cartridge |
US7078376B1 (en) | 2000-08-11 | 2006-07-18 | Baxter Healthcare S.A. | Therapeutic methods for treating subjects with a recombinant erythropoietin having high activity and reduced side effects |
WO2002017996A1 (en) | 2000-08-29 | 2002-03-07 | Novo Nordisk A/S | Automatic injection device with torsion function for retraction of needle |
US20030191291A1 (en) | 2000-09-08 | 2003-10-09 | Kochendoerfer Gerd G. | Synthetic erythropoiesis stimulating proteins |
EP1324792A2 (en) | 2000-09-21 | 2003-07-09 | Elan Pharma International Limited | Reconstitution and injection system |
AU2001289589A1 (en) | 2000-09-22 | 2002-04-02 | Novo-Nordisk A/S | A medication delivery device |
US6770052B2 (en) | 2000-10-10 | 2004-08-03 | Meridian Medical Technologies, Inc. | Wet/dry automatic injector assembly |
US6641561B1 (en) | 2000-10-10 | 2003-11-04 | Meridian Medical Technologies, Inc. | Drug delivery device |
US6652483B2 (en) | 2000-11-07 | 2003-11-25 | Avant Drug Delivery Systems, Inc. | Needleless jet injector system with separate drug reservoir |
US7271689B1 (en) | 2000-11-22 | 2007-09-18 | Fonar Corporation | Magnet structure |
US6503454B1 (en) | 2000-11-22 | 2003-01-07 | Xerox Corporation | Multi-ejector system for ejecting biofluids |
ATE439643T1 (de) | 2000-11-29 | 2009-08-15 | Docusys Inc | Vorrichtung zur abgabe eines arzneimittels mit einem verfolgungscode |
SE518981C2 (sv) | 2000-12-14 | 2002-12-17 | Shl Medical Ab | Autoinjektor |
WO2002049673A2 (en) | 2000-12-20 | 2002-06-27 | F. Hoffmann-La Roche Ag | Conjugates of erythropoietin (pep) with polyethylene glycol (peg) |
US6387078B1 (en) | 2000-12-21 | 2002-05-14 | Gillespie, Iii Richard D. | Automatic mixing and injecting apparatus |
IT1320868B1 (it) | 2000-12-29 | 2003-12-10 | Cane Srl | Dispositivo portatile per infusione di farmaci. |
WO2002060513A2 (en) | 2001-01-02 | 2002-08-08 | Safety Syringes, Inc. | Systems and method for tracking administration of medical products |
EP1399483B1 (en) | 2001-01-05 | 2010-04-14 | Pfizer Inc. | Antibodies to insulin-like growth factor i receptor |
EP1808193A1 (en) | 2001-02-14 | 2007-07-18 | Novo Nordisk A/S | Electronically controlled device |
JP3845857B2 (ja) | 2001-03-15 | 2006-11-15 | ニプロ株式会社 | 簡易薬液注入器 |
EP1383927B1 (en) | 2001-04-04 | 2009-07-08 | GenOdyssee | New polynucleotides and polypeptides of the erythropoietin gene |
US6817986B2 (en) | 2001-04-13 | 2004-11-16 | Avant Medical Corp. | Jet injector with data logging system for use in compliance and dose monitoring programs |
US6854620B2 (en) | 2001-04-13 | 2005-02-15 | Nipro Diabetes, Systems, Inc. | Drive system for an infusion pump |
EA010435B1 (ru) | 2001-05-11 | 2008-08-29 | Амген, Инк. | Связывающиеся с tall-1 молекулы и их применение |
WO2002092153A2 (en) | 2001-05-16 | 2002-11-21 | Eli Lilly And Company | Medication injector apparatus with drive assembly that facilitates reset |
US7308300B2 (en) | 2001-05-30 | 2007-12-11 | Acist Medical Systems, Inc. | Medical injection system |
JP2004535861A (ja) | 2001-06-05 | 2004-12-02 | バーネフ リミテッド | 出産モニタリングシステム |
US7025774B2 (en) | 2001-06-12 | 2006-04-11 | Pelikan Technologies, Inc. | Tissue penetration device |
DE10129584B4 (de) | 2001-06-20 | 2007-06-28 | Tecpharma Licensing Ag | Auslöseeinrichtung für einen Druckstrahlinjektor |
KR20040023630A (ko) | 2001-06-26 | 2004-03-18 | 아브게닉스, 인크. | Opgl에 결합하는 항체 |
US6416322B2 (en) | 2001-07-03 | 2002-07-09 | Danny W. Qualliotine | Powdering attachment for applying powder to tooth surfaces |
US6796957B2 (en) | 2001-07-10 | 2004-09-28 | Myocardial Therapeutics, Inc. | Sterile aspiration/reinjection systems |
US6835193B2 (en) | 2001-07-10 | 2004-12-28 | Myocardial Therapeutics, Inc. | Methods for controlled depth injections into interior body cavities |
AU2002345785B2 (en) | 2001-07-16 | 2007-11-15 | Eli Lilly And Company | Medication dispensing apparatus configured for rotate to prime and pull/push to inject functionality |
US20030065536A1 (en) | 2001-08-13 | 2003-04-03 | Hansen Henrik Egesborg | Portable device and method of communicating medical data information |
US6900292B2 (en) | 2001-08-17 | 2005-05-31 | Lee-Hwei K. Sun | Fc fusion proteins of human erythropoietin with increased biological activities |
BR0212136A (pt) | 2001-08-23 | 2004-12-07 | Genmab As | Anticorpo monoclonal humano isolado, métodos para inibir a produção de tnfa em células t ou monócitos e a proliferação de célula t, hibridoma, transfectoma, animal não humano transgênico, método para produzir um anticorpo monoclonal humano, composição farmacêutica, métodos para tratar ou prevenir um distúrbio mediado pela il-15 humana, a psorìase e a artrite reumatóide, método para diagnosticar uma doença, ácido nucleico, e, vetor de expressão |
US7247304B2 (en) | 2001-08-23 | 2007-07-24 | Genmab A/S | Methods of treating using anti-IL-15 antibodies |
US6669664B2 (en) | 2001-09-07 | 2003-12-30 | Avant Drug Delivery Systems, Inc. | Vacuum control cycle for jet injector |
EP1433456A4 (en) | 2001-09-12 | 2007-05-30 | Terumo Corp | MEDICATION CONTAINERS AND MEDICATION INJECTION DEVICE CONTAINING THEM |
US6930086B2 (en) | 2001-09-25 | 2005-08-16 | Hoffmann-La Roche Inc. | Diglycosylated erythropoietin |
US7214660B2 (en) | 2001-10-10 | 2007-05-08 | Neose Technologies, Inc. | Erythropoietin: remodeling and glycoconjugation of erythropoietin |
US7521053B2 (en) | 2001-10-11 | 2009-04-21 | Amgen Inc. | Angiopoietin-2 specific binding agents |
US7138370B2 (en) | 2001-10-11 | 2006-11-21 | Amgen Inc. | Specific binding agents of human angiopoietin-2 |
WO2003033363A1 (en) | 2001-10-16 | 2003-04-24 | Medical Instill Technologies, Inc. | Dispenser with sealed chamber and one-way valve for providing metered amounts of substances |
GB0125604D0 (en) | 2001-10-25 | 2001-12-19 | Glaxo Group Ltd | Novel process |
CA2465502C (en) | 2001-11-09 | 2011-03-22 | Pedro De La Serna | Pneumatic powered autoinjector |
CN100363063C (zh) * | 2001-11-09 | 2008-01-23 | 阿尔扎公司 | 伸缩式注射器筒 |
US20030105430A1 (en) | 2001-11-30 | 2003-06-05 | Elan Pharma International Limited Wil House | Automatic injector |
GB0129173D0 (en) | 2001-12-06 | 2002-01-23 | Dca Design Int Ltd | Improvements in and relating to a medicament cartridge |
GB0130140D0 (en) | 2001-12-18 | 2002-02-06 | Dca Design Int Ltd | Improvements in and relating to medicament delivery service |
US6648858B2 (en) | 2001-12-21 | 2003-11-18 | Visual Connections, Inc. | Safety device for a sheathed, prefilled injection syringe |
JP2005531282A (ja) * | 2001-12-21 | 2005-10-20 | ゲンパト77 ファーマコジェネティクス エージー | 炎症性疾患の治療に用いる抗tirc7抗体 |
JP2003180828A (ja) | 2001-12-21 | 2003-07-02 | Matsushita Electric Ind Co Ltd | 電動流体吐出装置 |
WO2003055526A2 (en) | 2001-12-21 | 2003-07-10 | Maxygen Aps | Erythropoietin conjugates |
JP4606739B2 (ja) | 2002-01-18 | 2011-01-05 | ピエール、ファーブル、メディカマン | 新規抗igf−ir抗体およびその使用 |
US7241444B2 (en) | 2002-01-18 | 2007-07-10 | Pierre Fabre Medicament | Anti-IGF-IR antibodies and uses thereof |
JP2003220142A (ja) | 2002-01-30 | 2003-08-05 | Yoshino Kogyosho Co Ltd | 注射器 |
EP1470232A1 (en) | 2002-01-31 | 2004-10-27 | Oxford Biomedica (UK) Limited | Physiologically regulated erythropoietin-expressing vector for the treatment of anaemia |
GB0202252D0 (en) | 2002-01-31 | 2002-03-20 | Oxford Biomedica Ltd | Anemia |
US6828908B2 (en) | 2002-02-06 | 2004-12-07 | Ronald Scott Clark | Locator system with an implanted transponder having an organically-rechargeable battery |
AUPS135702A0 (en) | 2002-03-25 | 2002-05-09 | Occupational & Medical Innovations Ltd | A medical syringe container |
US20050153879A1 (en) | 2002-03-26 | 2005-07-14 | Monica Svetina | Process for the preparation of a desired erythropoietin glyco-isoform profile |
WO2003084477A2 (en) | 2002-03-29 | 2003-10-16 | Centocor, Inc. | Mammalian cdr mimetibodies, compositions, methods and uses |
USD483116S1 (en) | 2002-04-05 | 2003-12-02 | Penjet Corporation | Needle-less injector |
US6960192B1 (en) | 2002-04-23 | 2005-11-01 | Insulet Corporation | Transcutaneous fluid delivery system |
EA006960B1 (ru) | 2002-05-02 | 2006-06-30 | Па Нолидж Лимитед | Инъекционное устройство |
US6808507B2 (en) | 2002-05-10 | 2004-10-26 | Cambridge Biostability Ltd. | Safety injectors |
US20040009902A1 (en) | 2002-05-13 | 2004-01-15 | Irving Boime | CTP extended erythropoietin |
US6979316B1 (en) | 2002-05-23 | 2005-12-27 | Seedlings Life Science Ventures Llc | Apparatus and method for rapid auto-injection of medication |
US20050171476A1 (en) | 2002-05-24 | 2005-08-04 | Judson Jared A. | Medication injecting apparatus with fluid container piston-engaging drive member having internal hollow for accommodating drive member shifting mechanism |
US7217796B2 (en) | 2002-05-24 | 2007-05-15 | Schering Corporation | Neutralizing human anti-IGFR antibody |
US7553294B2 (en) | 2002-05-30 | 2009-06-30 | Medrad, Inc. | Syringe plunger sensing mechanism for a medical injector |
US8641715B2 (en) | 2002-05-31 | 2014-02-04 | Vidacare Corporation | Manual intraosseous device |
US7811260B2 (en) | 2002-05-31 | 2010-10-12 | Vidacare Corporation | Apparatus and method to inject fluids into bone marrow and other target sites |
US7150724B2 (en) | 2002-06-05 | 2006-12-19 | Cardinal Health 303, Inc. | Syringe plunger driver system |
US8034904B2 (en) | 2002-06-14 | 2011-10-11 | Immunogen Inc. | Anti-IGF-I receptor antibody |
US7538195B2 (en) | 2002-06-14 | 2009-05-26 | Immunogen Inc. | Anti-IGF-I receptor antibody |
MY139059A (en) | 2002-06-24 | 2009-08-28 | Alza Corp | Reusable, spring driven autoinjector |
DE10229138B4 (de) | 2002-06-28 | 2008-01-31 | Tecpharma Licensing Ag | Produktausschüttvorrichtung mit Kolbenstangen-Eilrücksetzung |
WO2004002417A2 (en) | 2002-06-28 | 2004-01-08 | Centocor, Inc. | Mammalian ch1 deleted mimetibodies, compositions, methods and uses |
AU2003256336A1 (en) | 2002-06-28 | 2004-01-19 | Centocor, Inc. | Mammalian epo mimetic ch1 deleted mimetibodies, compositions, methods and uses |
EP2286857A1 (en) | 2002-07-02 | 2011-02-23 | Panasonic Corporation | Automatic administration instrument for medical use |
US7328064B2 (en) | 2002-07-04 | 2008-02-05 | Inovio As | Electroporation device and injection apparatus |
AU2003246486A1 (en) | 2002-07-19 | 2004-02-09 | Cangene Corporation | Pegylated erythropoietic compounds |
JP4406607B2 (ja) | 2002-08-26 | 2010-02-03 | オンコセラピー・サイエンス株式会社 | ペプチド及びこれを含む医薬 |
TWI347951B (en) | 2002-09-06 | 2011-09-01 | Amgen Inc | Therapeutic human anti-il-1r1 monoclonal antibody |
JP2006516534A (ja) | 2002-09-11 | 2006-07-06 | フレセニウス・カビ・ドイッチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | Has化ポリペプチド、特にhas化エリスロポエチン |
US6919426B2 (en) | 2002-09-19 | 2005-07-19 | Amgen Inc. | Peptides and related molecules that modulate nerve growth factor activity |
US7135027B2 (en) | 2002-10-04 | 2006-11-14 | Baxter International, Inc. | Devices and methods for mixing and extruding medically useful compositions |
US20040071694A1 (en) | 2002-10-14 | 2004-04-15 | Devries Peter J. | Erythropoietin receptor binding antibodies |
TWI320716B (en) | 2002-10-14 | 2010-02-21 | Abbott Lab | Erythropoietin receptor binding antibodies |
US7396913B2 (en) | 2002-10-14 | 2008-07-08 | Abbott Laboratories | Erythropoietin receptor binding antibodies |
AU2003285874A1 (en) | 2002-10-16 | 2004-05-04 | Amgen Inc. | HUMAN ANTI-IFN-Gamma NEUTRALIZING ANTIBODIES AS SELECTIVE IFN-Gamma PATHWAY INHIBITORS |
US20040091961A1 (en) | 2002-11-08 | 2004-05-13 | Evans Glen A. | Enhanced variants of erythropoietin and methods of use |
CN100415315C (zh) | 2002-11-25 | 2008-09-03 | 特克法马许可公司 | 用于临时保持注射装置的保护针罩的设备 |
EP1572271A1 (de) | 2002-11-25 | 2005-09-14 | Tecpharma Licensing AG | Autoinjektor mit rückstellbarer auslösesicherung |
CN100506305C (zh) | 2002-11-25 | 2009-07-01 | 特克法马许可公司 | 包括针保护设备的注射装置 |
GB0229345D0 (en) | 2002-12-17 | 2003-01-22 | Safe T Ltd | Hollow needle applicators |
MEP57508A (en) | 2002-12-20 | 2011-05-10 | Amgen Inc | Binding agents which inhibit myostatin |
US6767336B1 (en) | 2003-01-09 | 2004-07-27 | Sheldon Kaplan | Automatic injector |
US7699804B2 (en) | 2003-01-31 | 2010-04-20 | Creare Inc. | Fluid ejection system |
EP1603948A1 (en) | 2003-03-14 | 2005-12-14 | Pharmacia Corporation | Antibodies to igf-i receptor for the treatment of cancers |
CA2433205A1 (en) | 2003-03-18 | 2004-09-18 | James Alexander Keenan | Drug delivery, bodily fluid drainage, and biopsy device with enhanced ultrasonic visibility |
ATE402688T1 (de) | 2003-03-24 | 2008-08-15 | Novo Nordisk As | Transparentes elektronisches markieren eines medikamentenbehälters |
CA2519113C (en) | 2003-04-02 | 2012-06-05 | F. Hoffmann-La Roche Ag | Antibodies against insulin-like growth factor i receptor and uses thereof |
TWI235706B (en) | 2003-04-07 | 2005-07-11 | Sumitomo Heavy Industries | Method of controlling injection molding machine |
US8383158B2 (en) | 2003-04-15 | 2013-02-26 | Abbott Cardiovascular Systems Inc. | Methods and compositions to treat myocardial conditions |
US7220410B2 (en) | 2003-04-18 | 2007-05-22 | Galaxy Biotech, Llc | Monoclonal antibodies to hepatocyte growth factor |
US7638605B2 (en) | 2003-05-01 | 2009-12-29 | ImClone, LLC | Fully human antibodies directed against the human insulin-like growth factor-1 receptor |
US6805686B1 (en) | 2003-05-06 | 2004-10-19 | Abbott Laboratories | Autoinjector with extendable needle protector shroud |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
JP2007530440A (ja) | 2003-05-12 | 2007-11-01 | アフィーマックス・インコーポレイテッド | 新規ポリ(エチレングリコール)修飾化合物およびその用途 |
MXPA05012316A (es) | 2003-05-12 | 2006-04-18 | Affymax Inc | Peptidos novedosos que se unen al receptor de la eritropoyetina. |
WO2004101611A2 (en) | 2003-05-12 | 2004-11-25 | Affymax, Inc. | Peptides that bind to the erythropoietin receptor |
US7074755B2 (en) | 2003-05-17 | 2006-07-11 | Centocor, Inc. | Erythropoietin conjugate compounds with extended half-lives |
JP2006526467A (ja) | 2003-05-30 | 2006-11-24 | イーライ リリー アンド カンパニー | 複数チェンバー型投薬装置 |
US6995245B2 (en) | 2003-05-30 | 2006-02-07 | Centocor, Inc. | Formation of novel erythropoietin conjugates using transglutaminase |
US20050037390A1 (en) | 2003-06-04 | 2005-02-17 | Irm Llc, A Delaware Limited Liability Company | Methods and compositions for modulating erythropoietin expression |
AR046071A1 (es) | 2003-07-10 | 2005-11-23 | Hoffmann La Roche | Anticuerpos contra el receptor i del factor de crecimiento de tipo insulinico y los usos de los mismos |
ME02785B (me) | 2003-07-15 | 2012-12-31 | Amgen Inc | Humana anti-ngf neutrališuća antitela kao selektivni inhibitori ngf signalnog puta |
NZ544797A (en) | 2003-07-18 | 2011-04-29 | Amgen Fremont Inc | Specific antibodies that bind HGF and neutralise binding of HGF to met |
US7500963B2 (en) * | 2003-07-22 | 2009-03-10 | Safety Syringes, Inc. | Systems and methods for automatic medical injection with safeguard |
US20050019914A1 (en) | 2003-07-24 | 2005-01-27 | Aventis Pharma Deutschland Gmbh | Perfusion process for producing erythropoietin |
US20050022823A1 (en) | 2003-07-30 | 2005-02-03 | Suzanne Davison | Apparatus, system and method for treating dry eye conditions and promoting healthy eyes |
US20050027255A1 (en) | 2003-07-31 | 2005-02-03 | Sid Technologies, Llc | Automatic injector |
DE20311996U1 (de) | 2003-08-01 | 2003-10-16 | Hoelzle Dieter Tech Projekte | Injektionsvorrichtung |
US20090018505A1 (en) | 2003-08-11 | 2009-01-15 | Andrew Arguedas | Powered automatic injection device |
SI1656170T1 (sl) | 2003-08-12 | 2019-05-31 | Eli Lilly And Company | Oprema za izdajanje zdravil s trojnim vijačnim navojem za mehanski pospešek |
US7097637B2 (en) | 2003-08-27 | 2006-08-29 | C. R. Bard, Inc. | Safety needle with positive flush |
JP2007512001A (ja) | 2003-08-28 | 2007-05-17 | バイオレクシス ファーマシューティカル コーポレイション | Epoミメティックペプチドおよび融合タンパク質 |
DE10339794A1 (de) | 2003-08-28 | 2005-04-07 | Tecpharma Licensing Ag | Verabreichungsvorrichtung mit einer Schutzkappenabziehvorrichtung und einer Nadelschutzhülsenblockiereinrichtung |
CN1882355A (zh) | 2003-09-09 | 2006-12-20 | 沃伦药品公司 | 保持内源性促红细胞生成素组织保护活性的长效促红细胞生成素 |
DE10342059B4 (de) | 2003-09-11 | 2007-03-01 | Tecpharma Licensing Ag | Verabreichungsvorrichtung mit Einstech- und Ausschütteinrichtung |
IL157984A (en) | 2003-09-17 | 2015-02-26 | Dali Medical Devices Ltd | Automatic needle |
US8422413B2 (en) | 2003-09-18 | 2013-04-16 | Dentsply International Inc. | Process and device for the wireless transmission of dental process data |
CN1890383A (zh) | 2003-09-30 | 2007-01-03 | 森托科尔公司 | 人铰链核心模拟体、组合物、方法和用途 |
UA89481C2 (uk) | 2003-09-30 | 2010-02-10 | Центокор, Инк. | Еритропоетинові міметичні шарнірно-серцевинні міметитіла людини, композиції, способи та застосування |
WO2005032449A1 (en) | 2003-10-03 | 2005-04-14 | Novo Nordisk A/S | Container comprising code information elements |
JP2005131007A (ja) | 2003-10-29 | 2005-05-26 | Nemoto Kyorindo:Kk | 薬液注入システム |
US7635348B2 (en) | 2003-11-04 | 2009-12-22 | Meridian Medical Technologies, Inc. | Container for medicament automatic injector and automatic injector adapted therefor |
DE10351594A1 (de) | 2003-11-05 | 2005-06-16 | Tecpharma Licensing Ag | Vorrichtung für die Verabreichung eines injizierbaren Produkts |
DE10351596B4 (de) | 2003-11-05 | 2007-10-11 | Tecpharma Licensing Ag | Autoinjektor mit variabler Dosis |
UA93653C2 (ru) | 2003-11-07 | 2011-03-10 | Иммунекс Корпорейшн | Выделенное антитело, kotopoe специфически связывается c человеческим рецептором il-4 (il-4r) |
PE20050928A1 (es) | 2003-11-21 | 2005-11-08 | Schering Corp | Combinaciones terapeuticas de anticuerpo anti-igfr1 |
US7405198B2 (en) | 2003-11-24 | 2008-07-29 | Neose Technologies, Inc. | Glycopegylated erythropoietin |
US8633157B2 (en) | 2003-11-24 | 2014-01-21 | Novo Nordisk A/S | Glycopegylated erythropoietin |
US7666169B2 (en) | 2003-11-25 | 2010-02-23 | Medrad, Inc. | Syringe and syringe plungers for use with medical injectors |
EP1704505A2 (en) | 2003-12-04 | 2006-09-27 | Smiths Medical MD, Inc. | Programming medical pumps with electronic standing order template |
WO2005058967A2 (en) | 2003-12-16 | 2005-06-30 | Pierre Fabre Medicament | Novel anti-insulin/igf-i hybrid receptor or anti-insulin/igf-i hybrid receptor and igf-ir antibodies and uses thereof |
CH696421A5 (de) | 2003-12-18 | 2007-06-15 | Tecpharma Licensing Ag | Autoinjektor mit Arretierung des Wirkstoffbehälters. |
ATE446112T1 (de) | 2003-12-18 | 2009-11-15 | Tecpharma Licensing Ag | Auslösbares injektionsgerät |
EP1548031A1 (en) | 2003-12-22 | 2005-06-29 | Dubai Genetics FZ-LLC | Nature-identical erythropoietin |
WO2005063808A1 (en) | 2003-12-31 | 2005-07-14 | Merck Patent Gmbh | Fc-ERYTHROPOIETIN FUSION PROTEIN WITH IMPROVED PHARMACOKINETICS |
US20050170457A1 (en) | 2003-12-31 | 2005-08-04 | Chadler Pool | Novel recombinant proteins with N-terminal free thiol |
US7273469B1 (en) | 2003-12-31 | 2007-09-25 | Advanced Cardiovascular Systems, Inc. | Modified needle catheter for directional orientation delivery |
US7423139B2 (en) | 2004-01-20 | 2008-09-09 | Insight Biopharmaceuticals Ltd. | High level expression of recombinant human erythropoietin having a modified 5′-UTR |
WO2005070451A1 (en) | 2004-01-22 | 2005-08-04 | Zafena Aktiebolag | Pharmaceutical composition comprising non-glycosylated erythropoietin |
EP1715903B1 (en) | 2004-01-23 | 2007-10-24 | The Medical House Plc | Injection device |
DE102004005311A1 (de) | 2004-02-03 | 2005-08-18 | Tecpharma Licensing Ag | Ampullenerkennung |
WO2005079441A2 (en) | 2004-02-17 | 2005-09-01 | Children's Hospital Medical Center | Injection device for administering a vaccine |
PT1715904E (pt) * | 2004-02-18 | 2015-12-22 | Ares Trading Sa | Dispositivo portátil de injeção eletronicamente controlado para a injeção de medicação líquida |
WO2005084711A1 (fr) | 2004-03-02 | 2005-09-15 | Chengdu Institute Of Biological Products | Erythropoietine recombinante pegylee a activite in vivo |
EP1570875A1 (en) | 2004-03-04 | 2005-09-07 | Roche Diagnostics GmbH | Pyrotechnically driven needle-free liquid jet injection device with low-cost components and production |
JP4549079B2 (ja) | 2004-03-05 | 2010-09-22 | パナソニック株式会社 | 医療用投与器具 |
AR048918A1 (es) | 2004-03-11 | 2006-06-14 | Fresenius Kabi De Gmbh | Conjugados de almidon de hidroxietilo y eritropoyetina |
CA2559089C (en) | 2004-03-16 | 2012-10-09 | Glenord Pty. Ltd. | Single use retractable syringe |
ZA200608085B (en) | 2004-03-30 | 2008-06-25 | Novo Nordisk As | Actuator system comprising detection means |
DK1732628T3 (da) | 2004-03-30 | 2011-10-24 | Lilly Co Eli | Medicindoseringsapparat med gearsæt med åbning til et drivelement |
DK1732627T3 (da) | 2004-03-31 | 2010-08-16 | Lilly Co Eli | Injektionsapparat, som har en nålekassette til afgivelse af en farmaceutisk væske |
JP4507671B2 (ja) | 2004-03-31 | 2010-07-21 | パナソニック株式会社 | 医療用投与器具 |
US20050227289A1 (en) | 2004-04-09 | 2005-10-13 | Reilly Edward B | Antibodies to erythropoietin receptor and uses thereof |
WO2005103076A2 (en) | 2004-04-23 | 2005-11-03 | Cambridge Antibody Technology Limited | Erythropoietin protein variants |
GB2414405B (en) | 2004-05-28 | 2009-01-14 | Cilag Ag Int | Injection device |
GB2414399B (en) | 2004-05-28 | 2008-12-31 | Cilag Ag Int | Injection device |
GB2414404B (en) | 2004-05-28 | 2009-06-03 | Cilag Ag Int | Injection device |
ATE429444T1 (de) | 2004-07-07 | 2009-05-15 | Lundbeck & Co As H | Neues carbamyliertes epo und verfahren zu dessen herstellung |
JP4925828B2 (ja) | 2004-07-14 | 2012-05-09 | 株式会社根本杏林堂 | 薬液注入システム |
FR2873699B1 (fr) | 2004-07-29 | 2009-08-21 | Pierre Fabre Medicament Sa | Nouveaux anticorps anti igf ir rt leurs utilisations |
US7449012B2 (en) | 2004-08-06 | 2008-11-11 | Meridian Medical Technologies, Inc. | Automatic injector |
US7255684B2 (en) | 2004-08-09 | 2007-08-14 | Boris Zubry | Medical injection system |
DE102004039020B4 (de) | 2004-08-11 | 2018-01-25 | Tecpharma Licensing Ag | Autoinjektor |
US20060073563A1 (en) | 2004-09-02 | 2006-04-06 | Xencor, Inc. | Erythropoietin derivatives with altered immunogenicity |
WO2006045523A1 (en) | 2004-10-21 | 2006-05-04 | Novo Nordisk A/S | Medication delivery system with a detector for providing a signal indicative of an amount of an ejected dose of drug |
EP1814616A1 (en) | 2004-11-04 | 2007-08-08 | Sid Technologies Llc | Automatic injector |
AU2005303887A1 (en) | 2004-11-10 | 2006-05-18 | Aplagen Gmbh | Molecules which promote hematopoiesis |
WO2006051856A1 (ja) | 2004-11-11 | 2006-05-18 | Nemoto Kyorindo Co., Ltd. | 薬液注入システム |
CN101098723A (zh) | 2004-11-18 | 2008-01-02 | 株式会社根本杏林堂 | 药液注入系统 |
US7648483B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
US7648482B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems, and methods for medicament delivery |
US7597685B2 (en) | 2004-11-24 | 2009-10-06 | Shl Group Ab | Injection device |
US7905352B2 (en) | 2004-12-06 | 2011-03-15 | Washington Biotech Corporation | Kits containing medicine injection devices and containers |
US7297136B2 (en) | 2004-12-06 | 2007-11-20 | Wyrick Ronald E | Medicine injection devices and methods |
MY146381A (en) | 2004-12-22 | 2012-08-15 | Amgen Inc | Compositions and methods relating relating to anti-igf-1 receptor antibodies |
EP1841455A1 (en) | 2005-01-24 | 2007-10-10 | Amgen Inc. | Humanized anti-amyloid antibody |
US7731686B2 (en) | 2005-02-01 | 2010-06-08 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
CN101111281B (zh) | 2005-02-01 | 2013-02-06 | 因特利杰克特有限公司 | 用于药物递送的设备、系统和方法 |
US20060258986A1 (en) | 2005-02-11 | 2006-11-16 | Hunter Ian W | Controlled needle-free transport |
EP1858568A2 (en) | 2005-02-14 | 2007-11-28 | Novo Nordisk A/S | A dosing operation in a medical device |
ATE414551T1 (de) | 2005-02-21 | 2008-12-15 | Novo Nordisk As | Verfahren zur sicherstellung von konstanter motorgeschwindigkeit bei einer injektionsvorrichtung |
JP4762571B2 (ja) | 2005-02-24 | 2011-08-31 | 昭和薬品化工株式会社 | 歯科用カートリッジ式電動注射器における薬液注入速度制御装置 |
GB2424836B (en) | 2005-04-06 | 2010-09-22 | Cilag Ag Int | Injection device (bayonet cap removal) |
GB2427826B (en) | 2005-04-06 | 2010-08-25 | Cilag Ag Int | Injection device comprising a locking mechanism associated with integrally formed biasing means |
WO2006109778A1 (ja) | 2005-04-11 | 2006-10-19 | Nemoto Kyorindo Co., Ltd. | 薬液注入システム |
US7390319B2 (en) | 2005-04-13 | 2008-06-24 | Steven Friedman | Automatic needle injector having safety triggering mechanism |
FR2884721A1 (fr) | 2005-04-20 | 2006-10-27 | Becton Dickinson France Soc Pa | Ensemble d'injection et dispositif d'assistance a l'injection |
US7592429B2 (en) | 2005-05-03 | 2009-09-22 | Ucb Sa | Sclerostin-binding antibody |
US8277415B2 (en) | 2006-08-23 | 2012-10-02 | Medtronic Minimed, Inc. | Infusion medium delivery device and method with drive device for driving plunger in reservoir |
US7831545B1 (en) * | 2005-05-31 | 2010-11-09 | Google Inc. | Identifying the unifying subject of a set of facts |
US9011386B2 (en) | 2005-06-01 | 2015-04-21 | Shl Group Ab | Device for delivering medicament |
RU2502523C2 (ru) | 2005-06-17 | 2013-12-27 | Имклоун Элэлси | АНТИТЕЛА ПРОТИВ PDGFRα ДЛЯ ЛЕЧЕНИЯ ВТОРИЧНОЙ ОПУХОЛИ КОСТИ |
WO2007002053A2 (en) | 2005-06-21 | 2007-01-04 | Eli Lilly And Company | Needled pharmaceutical delivery device with triggered automatic needle insertion and manually controlled pharmaceutical injection |
WO2007000328A1 (en) | 2005-06-27 | 2007-01-04 | Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa | Antibodies that bind to an epitope on insulin-like growth factor 1 receptor and uses thereof |
US7955304B2 (en) | 2005-07-15 | 2011-06-07 | Shl Group Ab | Injector |
WO2007011941A2 (en) | 2005-07-18 | 2007-01-25 | Amgen Inc. | Human anti-b7rp1 neutralizing antibodies |
FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
US20070025879A1 (en) | 2005-07-27 | 2007-02-01 | Dakocytomation Denmark A/S | Method and apparatus for syringe-based sample introduction within a flow cytometer |
PE20071101A1 (es) | 2005-08-31 | 2007-12-21 | Amgen Inc | Polipeptidos y anticuerpos |
JP4850457B2 (ja) | 2005-09-06 | 2012-01-11 | キヤノン株式会社 | 薄膜トランジスタ及び薄膜ダイオード |
US8202249B2 (en) | 2005-09-20 | 2012-06-19 | Panasonic Corporation | Injection device with puncture function, method for controlling injection device with puncture function, chemical solution administration device, and method for controlling chemical solution administration device |
JP4983180B2 (ja) | 2005-09-20 | 2012-07-25 | パナソニック株式会社 | 穿刺機能付注射装置、穿刺機能付注射装置の制御方法、薬液投与装置、および薬液投与装置の制御方法 |
US7534226B2 (en) | 2005-09-26 | 2009-05-19 | M2 Group Holdings, Inc. | Dispensing fluid from an infusion pump system |
WO2007047200A1 (en) | 2005-10-11 | 2007-04-26 | Eli Lilly And Company | Apparatus for injecting a pharmaceutical |
EP1948112A4 (en) | 2005-10-11 | 2011-04-13 | Podaima Blake | SMART MEDICAL COMPLIANCE PROCESS AND SYSTEM |
US8672879B2 (en) | 2005-10-13 | 2014-03-18 | Argos Therapeutics, Inc. | Devices, systems and related methods suitable for delivery of a liquid medicament stored at cryogenic temperatures |
JP2007127086A (ja) | 2005-11-04 | 2007-05-24 | Terumo Corp | ポンプ |
US7713232B2 (en) | 2005-11-04 | 2010-05-11 | Medrad, Inc. | System for washing and processing of cells for delivery thereof to tissue |
US7988675B2 (en) | 2005-12-08 | 2011-08-02 | West Pharmaceutical Services Of Delaware, Inc. | Automatic injection and retraction devices for use with pre-filled syringe cartridges |
JP5112330B2 (ja) | 2005-12-20 | 2013-01-09 | アンタレス・ファーマ・インコーポレーテッド | 無針注入デバイス |
GB0601309D0 (en) | 2006-01-23 | 2006-03-01 | Medical House The Plc | Injection device |
US20070173770A1 (en) | 2006-01-23 | 2007-07-26 | The Medical House Plc | Injection device |
SI1980020T1 (sl) | 2006-01-31 | 2017-04-26 | Ares Trading S.A. | Vbrizgalna naprava s kapacitivnim senzorjem približevanja |
TW200744697A (en) | 2006-02-28 | 2007-12-16 | Verus Pharmaceuticals Inc | Shock absorber for an automatic injector |
WO2007099044A1 (en) | 2006-03-03 | 2007-09-07 | Shl Medical Ab | Medical device with orientation sensitive priming mechanism |
CA2905774C (en) | 2006-03-29 | 2019-02-19 | Kaleo, Inc. | Devices, systems and methods for medicament delivery |
FR2899482A1 (fr) | 2006-04-11 | 2007-10-12 | Becton Dickinson France Soc Pa | Dispositif d'injection automatique |
DE102006017209A1 (de) | 2006-04-12 | 2007-10-18 | Tecpharma Licensing Ag | Injektionsvorrichtung mit Spannfeder und Spannelement |
EP2010255B1 (en) | 2006-04-19 | 2012-04-11 | Novo Nordisk A/S | A fluid infusion system, a method of assembling such system and drug reservoir for use in the system |
TWI395754B (zh) | 2006-04-24 | 2013-05-11 | Amgen Inc | 人類化之c-kit抗體 |
EP2019701B1 (en) | 2006-05-16 | 2010-02-24 | Novo Nordisk A/S | A gearing mechanism for an injection device |
MX2008014744A (es) | 2006-05-19 | 2009-02-10 | Glycofi Inc | Composiciones de eritrocpoyetina. |
GB2438590B (en) | 2006-06-01 | 2011-02-09 | Cilag Gmbh Int | Injection device |
GB2438629B (en) | 2006-06-01 | 2011-02-23 | Cilag Gmbh Int | Injection device |
NZ573225A (en) | 2006-06-07 | 2012-02-24 | Acushot Inc | Charging mechanism for a needle-free injector with a piston actuator driven by a gas charge |
MX2008016335A (es) | 2006-06-30 | 2009-01-21 | Abbott Biotech Ltd | Dispositivo automatico de inyeccion. |
WO2008004670A1 (fr) | 2006-07-06 | 2008-01-10 | Nemoto Kyorindo Co., Ltd. | Système de remplissage et d'injection de liquide chimique, et dispositif de remplissage associé |
WO2008009645A1 (en) * | 2006-07-15 | 2008-01-24 | Novo Nordisk A/S | Medical delivery system with asymmetrical coding means |
US7618396B2 (en) | 2006-08-09 | 2009-11-17 | Avant Medical Corp. | Injection system with hidden needles |
US7681606B2 (en) | 2006-08-10 | 2010-03-23 | Fht, Inc. | Automated system and process for filling drug delivery devices of multiple sizes |
US7455663B2 (en) | 2006-08-23 | 2008-11-25 | Medtronic Minimed, Inc. | Infusion medium delivery system, device and method with needle inserter and needle inserter device and method |
DE102006053055A1 (de) | 2006-09-01 | 2008-04-17 | Tecpharma Licensing Ag | Nadelschutzvorrichtung mit blockierter Schutzposition |
CL2007002567A1 (es) | 2006-09-08 | 2008-02-01 | Amgen Inc | Proteinas aisladas de enlace a activina a humana. |
DE102007022791A1 (de) | 2006-09-15 | 2008-03-27 | Tecpharma Licensing Ag | Injektionsgerät mit verbesserter Befestigung des Produktbehälters |
US7767206B2 (en) | 2006-10-02 | 2010-08-03 | Amgen Inc. | Neutralizing determinants of IL-17 Receptor A and antibodies that bind thereto |
US7811254B2 (en) | 2006-10-18 | 2010-10-12 | Meridian Medical Technologies, Inc. | Autoinjector with needle depth adapter |
WO2008047372A2 (en) | 2006-10-19 | 2008-04-24 | Elcam Medical Agricultural Cooperative Association Ltd. | Automatic injection device |
US7760099B2 (en) | 2006-11-03 | 2010-07-20 | Codan Us Corporation | Radio frequency verification system and device |
EP1923084A1 (en) | 2006-11-17 | 2008-05-21 | Sanofi-Aventis Deutschland GmbH | Dosing and drive mechanism for drug delivery device |
EP1923083A1 (en) | 2006-11-17 | 2008-05-21 | Sanofi-Aventis Deutschland GmbH | Drive mechanisms for use in drug delivery devices |
WO2008059063A1 (en) * | 2006-11-17 | 2008-05-22 | Novo Nordisk A/S | A medical delivery system comprising a coding mechanism between dosing assembly and medicament container |
EP1923085A1 (en) | 2006-11-17 | 2008-05-21 | Sanofi-Aventis Deutschland GmbH | Dosing and drive mechanism for drug delivery device |
ES2741273T3 (es) | 2006-11-21 | 2020-02-10 | Kaleo Inc | Dispositivos y sistemas para administración de medicamento |
FR2908999B1 (fr) * | 2006-11-29 | 2012-04-27 | Biomerieux Sa | Nouveau medicament destine a l'inhibition, la prevention ou le traitement de la polyarthrite rhumatoide. |
US8382713B2 (en) | 2006-12-11 | 2013-02-26 | Kenergy Scientific, Inc. | Drug delivery device and methodology |
GB0625169D0 (en) | 2006-12-18 | 2007-01-24 | Medical House Plc The | Improved autoinjector |
US9326742B2 (en) | 2007-01-01 | 2016-05-03 | Bayer Healthcare Llc | Systems for integrated radiopharmaceutical generation, preparation, transportation and administration |
US20090270672A1 (en) * | 2007-01-09 | 2009-10-29 | Fago Frank M | Needle Cap Ejector for Radiation Shielded Syringe |
EP2125075A2 (en) | 2007-01-22 | 2009-12-02 | Intelliject, Inc. | Medical injector with compliance tracking and monitoring |
WO2008095124A1 (en) | 2007-01-31 | 2008-08-07 | Somark Innovations, Inc. | Device and method for providing a readable mark |
JP2010527248A (ja) | 2007-02-01 | 2010-08-12 | ピーエー ノウレッジ リミテッド | 自動注入器及び自動注入器の針を覆うアダプタ |
GB0704351D0 (en) | 2007-03-07 | 2007-04-11 | Medical House Plc The | Improved autoinjector |
CN101641127B (zh) | 2007-03-21 | 2012-11-28 | 诺沃-诺迪斯克有限公司 | 具有容器识别的医药输送系统和用于医药输送系统的容器 |
CN101678168B (zh) | 2007-03-22 | 2013-03-06 | 特克法马许可公司 | 具有受控制的注射针拉回功能的注射装置 |
EP2129414A1 (de) | 2007-03-22 | 2009-12-09 | Tecpharma Licensing AG | Injektionsvorrichtung mit auslösesicherungen |
US8597253B2 (en) | 2007-04-20 | 2013-12-03 | Bard Access Systems | Huber needle with safety sheath |
WO2008139458A2 (en) | 2007-05-11 | 2008-11-20 | Medingo Ltd. | A positive displacement pump |
GB0710433D0 (en) | 2007-05-31 | 2007-07-11 | Ucb Pharma Sa | Auto-injector |
US8171634B2 (en) | 2007-07-09 | 2012-05-08 | Pratt & Whitney Canada Corp. | Method of producing effusion holes |
GB2451665B (en) | 2007-08-08 | 2012-09-26 | Cilag Gmbh Int | Injection device |
JP5395077B2 (ja) | 2007-08-23 | 2014-01-22 | マリンクロッド エルエルシー | Rfエネルギを用いたシリンジ内容物検出 |
US8012120B2 (en) | 2007-09-13 | 2011-09-06 | Avant Medical Corp. | Device and method for the automatic initiation of an injection |
WO2009040602A1 (en) | 2007-09-25 | 2009-04-02 | Becton Dickinson France | Autoinject0r with deactivating means moveable by a safety shield |
EP2190501A1 (en) | 2007-09-28 | 2010-06-02 | Mallinckrodt Inc. | Coupling of powerhead ram and power injector syringe |
US7922695B2 (en) | 2007-10-18 | 2011-04-12 | Roche Diagnostics Operations, Inc. | Drug delivery pump drive using linear piezoelectric motor |
US8409141B2 (en) | 2007-11-12 | 2013-04-02 | Bang & Olufsen Medicom A/S | Auto injector with automatic needle retraction |
USD619702S1 (en) | 2007-11-15 | 2010-07-13 | Tecpharma Licensing Ag | Medicine injector |
DE102007055636A1 (de) | 2007-11-21 | 2009-05-28 | Robert Bosch Gmbh | Medikamenten-Dosiervorrichtung zum Verabreichen eines flüssigen Medikaments |
DE102007061775A1 (de) | 2007-12-20 | 2009-07-02 | Geiger Technik Gmbh | Spritzgussverfahren und zugehörige Anlage |
GB0800103D0 (en) | 2008-01-04 | 2008-02-13 | Owen Mumford Ltd | Sheath removver device |
MX2010008099A (es) | 2008-01-28 | 2010-08-04 | Medimmune Ltd | Anticuerpos y angiopoyetina-2 estabilizados y sus usos. |
JP5731829B2 (ja) | 2008-03-10 | 2015-06-10 | アンタレス・ファーマ・インコーポレーテッド | 注射器安全装置 |
US20090254060A1 (en) | 2008-04-02 | 2009-10-08 | Hetherington Hugh E | Motor assembly for injection control device |
WO2009125879A1 (en) | 2008-04-07 | 2009-10-15 | Jong-Soo Choi | Automatic injection apparatus |
US8801679B2 (en) | 2008-04-10 | 2014-08-12 | Panasonic Healthcare Co., Ltd. | Medication administering device |
RU2496528C2 (ru) | 2008-05-02 | 2013-10-27 | Санофи-Авентис Дойчланд Гмбх | Устройство подачи лекарственного средства |
PL2274030T5 (pl) | 2008-05-02 | 2021-08-30 | Sanofi-Aventis Deutschland Gmbh | Urządzenie do podawania leku |
US8052645B2 (en) | 2008-07-23 | 2011-11-08 | Avant Medical Corp. | System and method for an injection using a syringe needle |
US8177749B2 (en) * | 2008-05-20 | 2012-05-15 | Avant Medical Corp. | Cassette for a hidden injection needle |
ES2677599T3 (es) | 2008-05-30 | 2018-08-03 | Allergan, Inc. | Dispositivo de inyección para rellenos de aumento de tejido blando, agentes bioactivos y otros materiales biocompatibles en forma líquida o de gel |
GB2461088B (en) | 2008-06-19 | 2012-09-26 | Cilag Gmbh Int | Injection device |
ATE510575T1 (de) | 2008-06-30 | 2011-06-15 | Animas Corp | Antriebsmechanismus |
JP5236075B2 (ja) | 2008-07-15 | 2013-07-17 | エス・ホー・エル・グループ・アクチボラゲット | 薬剤送達装置 |
DK2326371T3 (da) | 2008-07-18 | 2019-11-18 | Ucb Biopharma Sprl | Systemer til indgift af medicin til patienter med rheumatoid arthritis |
AU2009279719B2 (en) | 2008-08-05 | 2015-07-23 | Antares Pharma, Inc. | Multiple dosage injector |
EP2251053B1 (en) | 2008-08-08 | 2013-10-23 | Mallinckrodt LLC | Power injector with automatic ram homing function |
DE102008037310B4 (de) | 2008-08-11 | 2023-11-16 | Ypsomed Ag | Automatische Injektionsvorrichtung für die Verabreichung einer festen Dosis |
USD636077S1 (en) | 2008-08-27 | 2011-04-12 | Deka Products Limited Partnership | Fluidic connector |
GB2463034B (en) | 2008-08-28 | 2012-11-07 | Owen Mumford Ltd | Autoinjection devices |
GB2463071A (en) | 2008-09-02 | 2010-03-03 | Owen Mumford Ltd | Auto-injector syringe with safety shield |
KR101251152B1 (ko) | 2008-09-10 | 2013-04-05 | 에프. 호프만-라 로슈 아게 | 치료용 약물과 함께 사용하기 위한 전달 장치 |
EP2326370B1 (en) | 2008-09-18 | 2020-08-05 | Becton, Dickinson and Company | Medical injector with slidable sleeve activation |
JP5563579B2 (ja) | 2008-09-29 | 2014-07-30 | ベクトン ディキンソン フランス | 自動注射装置 |
CN102170927A (zh) | 2008-10-06 | 2011-08-31 | 泰尔茂株式会社 | 注射器泵 |
USD619706S1 (en) | 2008-11-11 | 2010-07-13 | Artema Medical Ab | Pneumatic connector |
EP2355879B1 (en) | 2008-11-17 | 2016-03-23 | Becton Dickinson and Company | Additive force device for drug delivery pen for intradermal medication injection |
DE102008063517A1 (de) | 2008-12-18 | 2010-07-01 | Lts Lohmann Therapie-Systeme Ag | Einmalinjektor mit einem biegeelastischen Gehäuse II |
JP5717649B2 (ja) | 2008-12-29 | 2015-05-13 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 電動モータ駆動制御を備える医療注射デバイス |
US8152779B2 (en) | 2008-12-30 | 2012-04-10 | Medimop Medical Projects Ltd. | Needle assembly for drug pump |
EP2362791B1 (en) | 2009-02-04 | 2018-07-04 | Liebel-Flarsheim Company LLC | Syringe with visual use indicator |
EP2393534B1 (en) * | 2009-02-05 | 2015-03-25 | Sanofi-Aventis Deutschland GmbH | Medicament delivery devices |
DK2403562T3 (da) | 2009-03-05 | 2021-02-15 | Sanofi Aventis Deutschland | Lægemiddeladministrationsanordning, der viser brugsrelateret information |
BRPI1010235B1 (pt) | 2009-03-30 | 2020-03-17 | Sanofi-Aventis Deutschland Gmbh | Dispositivo de liberação de fármaco com uma haste do pistão melhorada |
EP2414011B1 (en) | 2009-04-01 | 2016-04-27 | SHL Group AB | Medicament delivery device |
CA2761052C (en) | 2009-04-08 | 2017-11-07 | John K. Bruce | Medical fluid delivery system with reusable rfid fixture |
WO2010123439A1 (en) | 2009-04-24 | 2010-10-28 | Shl Group Ab | Medicament delivery device |
US20110023281A1 (en) | 2009-04-30 | 2011-02-03 | Stat Medical Devices, Inc. | Pen injection device cap with integral pen needle quick release and/or removal system |
JP5808737B2 (ja) | 2009-05-07 | 2015-11-10 | メディカル・インジェクション・デヴァイシズ・インコーポレーテッド | 薬剤分注デバイス |
AU2010276522B2 (en) | 2009-07-29 | 2016-03-10 | Icu Medical, Inc. | Fluid transfer devices and methods of use |
EP2292286A1 (en) | 2009-09-07 | 2011-03-09 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a medication delivery device and medication delivery device |
ES2393278T3 (es) * | 2009-09-25 | 2012-12-20 | Carebay Europe Limited | Dispositivo de administración médica |
DE102009048497A1 (de) | 2009-09-26 | 2011-03-31 | Haselmeier Gmbh | Injektionsgerät |
AR078457A1 (es) | 2009-09-30 | 2011-11-09 | Sanofi Aventis Deutschland | Mecanismo accionador para un dispositivo de descarga de farmacos |
US20110097229A1 (en) | 2009-10-09 | 2011-04-28 | Cauley Iii Thomas Henry | Feedback Controlled Syringe Pump |
CN102665805B (zh) | 2009-10-16 | 2017-12-08 | 詹森生物科技公司 | 手掌激活型药物递送装置 |
US8394053B2 (en) * | 2009-11-06 | 2013-03-12 | Crisi Medical Systems, Inc. | Medication injection site and data collection system |
WO2011057065A1 (en) | 2009-11-06 | 2011-05-12 | The Uab Research Foundation | Apparatuses and methods for delivering substances to the inner eye |
USD637713S1 (en) | 2009-11-20 | 2011-05-10 | Carmel Pharma Ab | Medical device adaptor |
WO2011069935A2 (en) | 2009-12-07 | 2011-06-16 | Sanofi-Aventis Deutschland Gmbh | Drive assembly for a drug delivery device and drug delivery device |
EP3421028A3 (en) | 2010-01-22 | 2019-04-10 | Sanofi-Aventis Deutschland GmbH | Coded collapsible drug reservoir |
JP5598903B2 (ja) | 2010-01-29 | 2014-10-01 | 富士電機エフテック株式会社 | 薬液用電動注射器 |
EP2351591A1 (en) | 2010-02-02 | 2011-08-03 | Sanofi-Aventis Deutschland GmbH | Assembly for a drug delivery device and drug delivery device |
CA2790190A1 (en) | 2010-02-17 | 2011-08-25 | Sanofi-Aventis Deutschland Gmbh | Automatic injection device with torsional spring |
US9572937B2 (en) | 2010-02-18 | 2017-02-21 | Sanofi-Aventis Deutschland Gmbh | Autoinjector having piston rod with non-circular axial bore slidably arranged on housing shaft to prevent relative rotation |
US8911410B2 (en) | 2010-02-18 | 2014-12-16 | Sanofi-Aventis Deutschland Gmbh | Auto-injector |
DK2538993T3 (en) | 2010-02-22 | 2017-02-06 | Sanofi Aventis Deutschland | Auto injector with gearbox |
CN102781498B (zh) | 2010-03-01 | 2014-05-21 | 松下电器产业株式会社 | 药剂投放装置 |
US20110270220A1 (en) | 2010-03-03 | 2011-11-03 | Aktivpak, Inc. | Linearly actuated dispenser and therapeutic package suitable for administering a therapeutic substance and related method |
USD625015S1 (en) | 2010-03-12 | 2010-10-05 | Sonosite, Inc. | Medical device stand docking station |
IL211800A (en) | 2010-03-21 | 2014-03-31 | Isaac Zukier | Liquid or clot injection device |
EP2555816A1 (en) | 2010-04-09 | 2013-02-13 | Sanofi-Aventis Deutschland GmbH | Method and system for differentiating drug delivery devices |
CA2736841C (en) | 2010-04-15 | 2014-02-18 | Teneo Innovations Inc. | Device and electronic controller for syringe piston control |
MX2012013426A (es) | 2010-05-20 | 2013-02-12 | Becton Dickinson Co | Dispositivo de administracion de farmacos. |
CA2801865A1 (en) | 2010-06-11 | 2011-12-15 | Sanofi-Aventis Deutschland Gmbh | Drug delivery device with drive member having indication elements |
US9408977B2 (en) | 2010-06-11 | 2016-08-09 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for a drug delivery device and drug delivery device |
US8961473B2 (en) | 2010-06-11 | 2015-02-24 | Sanofi-Aventis Deutschland Gmbh | Drive mechanism for a drug delivery device and drug delivery device |
EP2399627A1 (en) | 2010-06-28 | 2011-12-28 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
EP2399634A1 (en) | 2010-06-28 | 2011-12-28 | Sanofi-Aventis Deutschland GmbH | Needle safety arrangement and method for operating it |
JP6165628B2 (ja) * | 2010-08-19 | 2017-07-19 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 電子センサを使用して、薬物リザーバに関わる情報を決定するための方法及びシステム |
USD642261S1 (en) | 2010-09-15 | 2011-07-26 | Abbott Medical Optics Inc. | Securing device for cannula attachment to syringe body |
USD650070S1 (en) | 2010-09-16 | 2011-12-06 | Panasonic Corporation | Injector |
EP2438949A1 (en) | 2010-10-06 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a drug delivery device and drug delivery device |
EP2438942A1 (en) | 2010-10-08 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
EP2438946A1 (en) | 2010-10-08 | 2012-04-11 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
JP5968325B2 (ja) | 2010-11-03 | 2016-08-10 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 薬物の漏出防止のための方法及びシステム |
TWI459986B (zh) * | 2010-11-08 | 2014-11-11 | Shl Group Ab | 容器支撐總成 |
EP2452711A1 (en) | 2010-11-12 | 2012-05-16 | Sanofi-Aventis Deutschland GmbH | Drive mechanism for a drug delivery device and drug delivery device |
US8609621B2 (en) | 2010-11-15 | 2013-12-17 | E I Du Pont De Nemours And Company | Acid-cleavable linkers exhibiting altered rates of acid hydrolysis |
EP2460553A1 (fr) | 2010-12-02 | 2012-06-06 | Debiotech S.A. | Dispositif pour l'insertion d'aiguilles |
GB201020475D0 (en) | 2010-12-02 | 2011-01-19 | Oval Medical Technologies Ltd | Delivery mechanism for an autoinjector |
GB201020472D0 (en) | 2010-12-02 | 2011-01-19 | Oval Medical Technologies Ltd | A drive assembly for an autoinjector |
CA2821367A1 (en) | 2010-12-17 | 2012-06-21 | Sanofi-Aventis Deutschland Gmbh | Medicament administration |
EP2468341A1 (en) * | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
EP2468329A1 (en) | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Auto injector with a torsion spring |
EP2468333A1 (en) | 2010-12-21 | 2012-06-27 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
USD679008S1 (en) | 2011-01-07 | 2013-03-26 | Remot Medical Innovation, LLC | Endotracheal tube adaptor |
USD677380S1 (en) | 2011-01-24 | 2013-03-05 | Abbvie Biotechnology Ltd. | Automatic injection device |
SG10201707191UA (en) | 2011-01-24 | 2017-10-30 | Abbvie Biotechnology Ltd | Removal of needle shields from syringes and automatic injection devices |
EP2489385A1 (en) | 2011-02-18 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
EP2489390A1 (en) | 2011-02-18 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Detent mechanism |
EP2489383A1 (en) | 2011-02-18 | 2012-08-22 | Sanofi-Aventis Deutschland GmbH | Auto-injector |
GB2488579A (en) | 2011-03-02 | 2012-09-05 | Owen Mumford Ltd | Autoinjector with "injection complete" indicator |
US20120253314A1 (en) | 2011-03-30 | 2012-10-04 | Ziv Harish | Palm-controlled injectors |
CA2833748C (en) | 2011-04-20 | 2019-07-16 | Amgen Inc. | Autoinjector apparatus |
AU2012245211B2 (en) | 2011-04-21 | 2016-03-10 | Abbvie Inc. | Wearable automatic injection device |
WO2012164404A2 (en) | 2011-06-02 | 2012-12-06 | Ucb Pharma S.A. | Auto-injector |
US8496619B2 (en) | 2011-07-15 | 2013-07-30 | Antares Pharma, Inc. | Injection device with cammed ram assembly |
USD679391S1 (en) | 2011-07-19 | 2013-04-02 | Timothy Mark Chinowsky | Cartridge for medical device |
EP2750737A1 (en) | 2011-08-29 | 2014-07-09 | Sid Technologies LLC | Subcutaneous and intradermal patch infusers |
JP6085607B2 (ja) | 2011-09-09 | 2017-02-22 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | 再装填式自動注射器 |
EP2583704A1 (en) | 2011-10-21 | 2013-04-24 | Sanofi-Aventis Deutschland GmbH | Autoinjector |
IL216158A0 (en) | 2011-11-06 | 2011-12-29 | Medimop Medical Projects Ltd | Electronic autoinjector apparatus and cassettes for use therewith |
EP2780020A4 (en) | 2011-11-14 | 2016-03-02 | Regenerative Sciences Llc | SUSPENDED PARTICLE DISTRIBUTION SYSTEMS AND METHODS |
USD673677S1 (en) | 2011-12-14 | 2013-01-01 | Insightra Medical, Inc. | Fibrotic band interrupter and implant introducing device |
EP2606925A1 (en) | 2011-12-21 | 2013-06-26 | Sanofi-Aventis Deutschland GmbH | Autoinjector |
USD702835S1 (en) | 2012-01-04 | 2014-04-15 | Anteis Sa | Needle retaining device |
EP2819724B1 (en) | 2012-02-27 | 2019-03-20 | F.Hoffmann-La Roche Ag | Spring force assembly for biasing or actuating stoppers of syringes, injection pen cartridges and the like |
EP2633874A1 (en) | 2012-03-02 | 2013-09-04 | Sanofi-Aventis Deutschland GmbH | Fixed-dose medicament delivery device |
US8523803B1 (en) | 2012-03-20 | 2013-09-03 | Medtronic Minimed, Inc. | Motor health monitoring and medical device incorporating same |
US8603026B2 (en) | 2012-03-20 | 2013-12-10 | Medtronic Minimed, Inc. | Dynamic pulse-width modulation motor control and medical device incorporating same |
US8603027B2 (en) | 2012-03-20 | 2013-12-10 | Medtronic Minimed, Inc. | Occlusion detection using pulse-width modulation and medical device incorporating same |
USD898908S1 (en) | 2012-04-20 | 2020-10-13 | Amgen Inc. | Pharmaceutical product cassette for an injection device |
TR201808673T4 (tr) | 2012-05-30 | 2018-07-23 | Sanofi Aventis Deutschland | Bir ilaç dağıtım cihazına yönelik tahrik mekanizması ve ilaç dağıtım cihazı. |
EP2674180A1 (en) | 2012-06-15 | 2013-12-18 | Ares Trading S.A. | Injection device |
US10238796B2 (en) | 2012-06-27 | 2019-03-26 | Sanofi-Aventis Deutschland Gmbh | Linear actor arrangement |
CA2882229C (en) | 2012-08-20 | 2018-10-30 | Carebay Europe Ltd | Automatic injection device |
US8960827B2 (en) | 2012-08-24 | 2015-02-24 | Ssw Holding Company, Inc. | Anti-tip and retention assembly for appliance support plate |
USD718439S1 (en) | 2012-12-17 | 2014-11-25 | B. Braun Melsungen Ag | Actuator assembly for a valved catheter |
EP4349383A2 (en) | 2013-02-11 | 2024-04-10 | Antares Pharma, Inc. | Needle assisted jet injection device having reduced trigger force |
US9308321B2 (en) | 2013-02-18 | 2016-04-12 | Medtronic Minimed, Inc. | Infusion device having gear assembly initialization |
JP6030803B2 (ja) | 2013-03-11 | 2016-11-24 | アンタレス・ファーマ・インコーポレーテッド | ピニオンシステムを有する用量注射器 |
JP6768501B2 (ja) | 2013-03-15 | 2020-10-14 | アムゲン・インコーポレーテッド | 薬物カセット、自動注入機、および自動注入機システム |
EP2968760B1 (en) | 2013-03-15 | 2024-01-03 | Amgen Inc. | Drug cassette, autoinjector, and autoinjector system |
EP2991705B1 (en) | 2013-05-01 | 2019-10-16 | UNL Holdings LLC | Plunger-driven auto-injectors |
US9340346B2 (en) | 2013-11-21 | 2016-05-17 | Smarthealth, Inc. | Precision dispensing device of small volume from pre-filled syringes |
USD748783S1 (en) | 2014-03-12 | 2016-02-02 | Adhezion Biomedical, Llc | Dispensing applicator |
JP2015186876A (ja) | 2014-03-27 | 2015-10-29 | 日清紡メカトロニクス株式会社 | ダイアフラムシートの製造方法 |
JP6330058B2 (ja) | 2014-04-29 | 2018-05-23 | ケアベイ・ヨーロッパ・リミテッドCarebay Europe Limited | 針の挿入深さを調節する装置 |
USD768852S1 (en) | 2014-06-30 | 2016-10-11 | Htl-Strefa Spolka Akcyjna | Safety needle device |
USD768851S1 (en) | 2014-06-30 | 2016-10-11 | Htl-Strefa Spolka Akcyjna | Safety needle device |
USD765241S1 (en) | 2014-09-15 | 2016-08-30 | Owen Mumford Ltd. | Syringe |
USD757254S1 (en) | 2015-01-07 | 2016-05-24 | Sanofi-Aventis Deutschland Gmbh | Autoinjector housing |
-
2012
- 2012-04-20 CA CA2833748A patent/CA2833748C/en active Active
- 2012-04-20 ES ES12774589T patent/ES2725785T3/es active Active
- 2012-04-20 EP EP19154409.7A patent/EP3498323B1/en active Active
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2009143255A1 (en) * | 2008-05-20 | 2009-11-26 | Avant Medical Corp. | Autoinjector system |
WO2010099850A1 (de) * | 2009-03-03 | 2010-09-10 | Dieter Hölzle Technik-Projekte GmbH | Injektionsvorrichtung mit injektionsvolumeneinstellung |
JP2016214237A (ja) * | 2010-06-28 | 2016-12-22 | ネステク ソシエテ アノニム | 低カロリー高タンパク質の栄養組成物及び該栄養組成物を用いる方法 |
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