JP2015091902A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2015091902A5 JP2015091902A5 JP2015031316A JP2015031316A JP2015091902A5 JP 2015091902 A5 JP2015091902 A5 JP 2015091902A5 JP 2015031316 A JP2015031316 A JP 2015031316A JP 2015031316 A JP2015031316 A JP 2015031316A JP 2015091902 A5 JP2015091902 A5 JP 2015091902A5
- Authority
- JP
- Japan
- Prior art keywords
- factor viii
- viii composition
- liquid
- optionally
- reconstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US25527999A | 1999-02-22 | 1999-02-22 | |
| US09/255,279 | 1999-02-22 | ||
| US45275299A | 1999-12-01 | 1999-12-01 | |
| US09/452,752 | 1999-12-01 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013227977A Division JP6038003B2 (ja) | 1999-02-22 | 2013-11-01 | アルブミンを含有していない新規の第viii因子処方物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015220875A Division JP6253627B2 (ja) | 1999-02-22 | 2015-11-11 | アルブミンを含有していない新規の第viii因子処方物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015091902A JP2015091902A (ja) | 2015-05-14 |
| JP2015091902A5 true JP2015091902A5 (enExample) | 2016-01-07 |
| JP6155442B2 JP6155442B2 (ja) | 2017-07-05 |
Family
ID=26944588
Family Applications (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000599425A Expired - Lifetime JP5149470B2 (ja) | 1999-02-22 | 2000-02-22 | 新規のアルブミンを含有していない第viii因子処方物 |
| JP2008120035A Expired - Lifetime JP5006832B2 (ja) | 1999-02-22 | 2008-05-01 | アルブミンを含有していない新規の第viii因子処方物 |
| JP2008255510A Expired - Lifetime JP5140539B2 (ja) | 1999-02-22 | 2008-09-30 | アルブミンを含有していない新規の第viii因子処方物 |
| JP2012009767A Expired - Lifetime JP5596064B2 (ja) | 1999-02-22 | 2012-01-20 | アルブミンを含有していない新規の第viii因子処方物 |
| JP2013227977A Expired - Lifetime JP6038003B2 (ja) | 1999-02-22 | 2013-11-01 | アルブミンを含有していない新規の第viii因子処方物 |
| JP2015031316A Expired - Lifetime JP6155442B2 (ja) | 1999-02-22 | 2015-02-20 | アルブミンを含有していない新規の第viii因子処方物 |
| JP2015220875A Expired - Lifetime JP6253627B2 (ja) | 1999-02-22 | 2015-11-11 | アルブミンを含有していない新規の第viii因子処方物 |
| JP2017088289A Withdrawn JP2017125076A (ja) | 1999-02-22 | 2017-04-27 | アルブミンを含有していない新規の第viii因子処方物 |
| JP2018125917A Pending JP2018172413A (ja) | 1999-02-22 | 2018-07-02 | アルブミンを含有していない新規の第viii因子処方物 |
Family Applications Before (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2000599425A Expired - Lifetime JP5149470B2 (ja) | 1999-02-22 | 2000-02-22 | 新規のアルブミンを含有していない第viii因子処方物 |
| JP2008120035A Expired - Lifetime JP5006832B2 (ja) | 1999-02-22 | 2008-05-01 | アルブミンを含有していない新規の第viii因子処方物 |
| JP2008255510A Expired - Lifetime JP5140539B2 (ja) | 1999-02-22 | 2008-09-30 | アルブミンを含有していない新規の第viii因子処方物 |
| JP2012009767A Expired - Lifetime JP5596064B2 (ja) | 1999-02-22 | 2012-01-20 | アルブミンを含有していない新規の第viii因子処方物 |
| JP2013227977A Expired - Lifetime JP6038003B2 (ja) | 1999-02-22 | 2013-11-01 | アルブミンを含有していない新規の第viii因子処方物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015220875A Expired - Lifetime JP6253627B2 (ja) | 1999-02-22 | 2015-11-11 | アルブミンを含有していない新規の第viii因子処方物 |
| JP2017088289A Withdrawn JP2017125076A (ja) | 1999-02-22 | 2017-04-27 | アルブミンを含有していない新規の第viii因子処方物 |
| JP2018125917A Pending JP2018172413A (ja) | 1999-02-22 | 2018-07-02 | アルブミンを含有していない新規の第viii因子処方物 |
Country Status (19)
| Country | Link |
|---|---|
| US (8) | US6586573B1 (enExample) |
| EP (5) | EP1820516B1 (enExample) |
| JP (9) | JP5149470B2 (enExample) |
| CN (3) | CN100553678C (enExample) |
| AT (1) | ATE365052T1 (enExample) |
| AU (1) | AU777972B2 (enExample) |
| BR (1) | BR0008405B1 (enExample) |
| CA (4) | CA2362927C (enExample) |
| CY (2) | CY1108030T1 (enExample) |
| CZ (3) | CZ307715B6 (enExample) |
| DE (1) | DE60035260T2 (enExample) |
| DK (4) | DK1154796T3 (enExample) |
| ES (4) | ES2541470T3 (enExample) |
| HK (1) | HK1213801A1 (enExample) |
| MX (1) | MXPA01008515A (enExample) |
| PL (4) | PL198123B1 (enExample) |
| PT (4) | PT2130554E (enExample) |
| RU (1) | RU2244556C2 (enExample) |
| WO (1) | WO2000048635A1 (enExample) |
Families Citing this family (135)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7253262B2 (en) * | 1995-01-19 | 2007-08-07 | Quandrant Drug Delivery Limited | Dried blood factor composition comprising trehalose |
| GB9501040D0 (en) * | 1995-01-19 | 1995-03-08 | Quadrant Holdings Cambridge | Dried composition |
| US7244824B2 (en) * | 1995-01-19 | 2007-07-17 | Quadrant Drug Delivery Limited | Dried blood factor composition comprising trehalose |
| US6214054B1 (en) | 1998-09-21 | 2001-04-10 | Edwards Lifesciences Corporation | Method for fixation of biological tissues having mitigated propensity for post-implantation calcification and thrombosis and bioprosthetic devices prepared thereby |
| EP1820516B1 (en) * | 1999-02-22 | 2013-07-24 | University of Connecticut | Novel albumin-free factor VIII formulations |
| US6830917B2 (en) * | 2001-12-10 | 2004-12-14 | Baxter Healthcare S.A. | Method of isolation and purification of trypsin from pronase protease and use thereof |
| JP2005530683A (ja) | 2001-12-21 | 2005-10-13 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第vii因子ポリペプチドの液体組成物 |
| KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
| US6878168B2 (en) | 2002-01-03 | 2005-04-12 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
| US6982080B2 (en) * | 2002-03-15 | 2006-01-03 | Wyeth | Hydroxyethyl starch—containing polypeptide compositions |
| GB0207092D0 (en) * | 2002-03-26 | 2002-05-08 | Sod Conseils Rech Applic | Stable pharmaceutical composition containing factor VIII |
| US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
| CN101912601B (zh) | 2002-06-21 | 2012-08-29 | 诺和诺德医疗保健公司 | 因子vii多肽的稳定化固体组合物 |
| GB0304636D0 (en) * | 2003-02-28 | 2003-04-02 | Britannia Pharmaceuticals Ltd | Pharmaceutical composition for nasal delivery |
| CA2518327A1 (en) * | 2003-03-18 | 2004-09-30 | Novo Nordisk Health Care Ag | Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides |
| US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
| KR20060015574A (ko) * | 2003-05-23 | 2006-02-17 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 용액 중 단백질 안정화 |
| ES2382157T3 (es) * | 2003-06-25 | 2012-06-05 | Novo Nordisk Health Care Ag | Composición líquida de polipépttidos del factor VII |
| JP5306597B2 (ja) * | 2003-07-01 | 2013-10-02 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第vii因子ポリペプチドの液体水性薬学的組成物 |
| DE10333317A1 (de) * | 2003-07-22 | 2005-02-17 | Biotecon Therapeutics Gmbh | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| AU2004261353B2 (en) * | 2003-08-05 | 2009-12-10 | Novo Nordisk A/S | Novel insulin derivatives |
| KR100560697B1 (ko) * | 2003-08-06 | 2006-03-16 | 씨제이 주식회사 | 알부민을 함유하지 않는 에리스로포이에틴 제제 |
| EP1656158B1 (en) | 2003-08-14 | 2016-03-09 | Novo Nordisk Health Care AG | Liquid, aqueous pharmaceutical composition of factor vii polypeptides |
| CZ300795B6 (cs) * | 2003-09-02 | 2009-08-12 | Pliva-Lachema A. S. | Farmaceutická kompozice a zpusob její výroby |
| US8541002B2 (en) * | 2003-09-12 | 2013-09-24 | Agenus Inc. | Vaccine for treatment and prevention of herpes simplex virus infection |
| EP2311437A1 (en) * | 2003-12-19 | 2011-04-20 | Novo Nordisk Health Care AG | Stabilised compositions of factor VII polypeptides |
| GB0404586D0 (en) * | 2004-03-01 | 2004-04-07 | Britannia Pharmaceuticals Ltd | Improvements in or relating to organic materials |
| JP2007526329A (ja) * | 2004-03-04 | 2007-09-13 | ワイス | 賦形剤の結晶化を改善するための凍結乾燥法 |
| WO2005094873A1 (en) * | 2004-03-19 | 2005-10-13 | Baxter International Inc. | Factor ixa for the treatment of bleeding disorders |
| US7319032B2 (en) * | 2004-04-22 | 2008-01-15 | Medtox | Non-sugar sweeteners for use in test devices |
| KR100624013B1 (ko) * | 2004-06-25 | 2006-09-19 | 주식회사 녹십자홀딩스 | 동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제 |
| AU2005322067B8 (en) | 2004-12-27 | 2012-07-26 | Takeda Pharmaceutical Company Limited | Polymer-von Willebrand factor-conjugates |
| FR2881139A1 (fr) * | 2005-01-26 | 2006-07-28 | Agronomique Inst Nat Rech | Composition pour la lyophilisation de proteines |
| EP2377554A1 (en) * | 2005-07-22 | 2011-10-19 | Amgen, Inc | Concentrated protein lyophilates, methods and uses |
| US20070135343A1 (en) | 2005-11-01 | 2007-06-14 | Wyeth | Sodium chloride solution for drug reconstitution or dilution |
| JP5757674B2 (ja) * | 2005-11-09 | 2015-07-29 | 味の素株式会社 | カルシウム受容体活性化剤 |
| US8420144B2 (en) * | 2005-11-09 | 2013-04-16 | Ajinomoto Co., Inc. | Kokumi-imparting agent, method of using, and compositions containing same |
| DE602006017421D1 (de) * | 2005-11-09 | 2010-11-18 | Ajinomoto Kk | Screening-verfahren für kokumi-vermittelnde agentien |
| KR20080071192A (ko) * | 2005-11-22 | 2008-08-01 | 와이어쓰 | 면역글로불린 융합 단백질 제형 |
| EP1969004B1 (en) | 2005-12-28 | 2011-08-10 | Novo Nordisk A/S | Compositions comprising an acylated insulin and zinc and method of making the said compositions |
| WO2007126808A1 (en) * | 2006-03-31 | 2007-11-08 | Baxter International Inc | Pegylated factor viii |
| US7982010B2 (en) | 2006-03-31 | 2011-07-19 | Baxter International Inc. | Factor VIII polymer conjugates |
| US7645860B2 (en) | 2006-03-31 | 2010-01-12 | Baxter Healthcare S.A. | Factor VIII polymer conjugates |
| US7985839B2 (en) | 2006-03-31 | 2011-07-26 | Baxter International Inc. | Factor VIII polymer conjugates |
| EP2029740B1 (en) * | 2006-05-31 | 2012-06-20 | Genzyme Corporation | Use of polysaccharides for promotion of enzymatic activity |
| US8007992B2 (en) | 2006-10-27 | 2011-08-30 | Edwards Lifesciences Corporation | Method of treating glutaraldehyde-fixed pericardial tissue with a non-aqueous mixture of glycerol and a C1-C3 alcohol |
| CN101808657A (zh) * | 2006-11-07 | 2010-08-18 | 赛诺菲巴斯德生物制剂公司 | 冻干法稳定疫苗 |
| DK2101821T3 (da) | 2006-12-15 | 2014-10-06 | Baxter Healthcare Sa | Faktor VIIA-(poly)sialinsyre-konjugat med forlænget halveringstid in vivo |
| FR2913020B1 (fr) | 2007-02-23 | 2012-11-23 | Biomethodes | Nouveaux facteurs viii pour le traitement des hemophiles de type a |
| ES2365832T3 (es) * | 2007-03-05 | 2011-10-11 | Cadila Healthcare Limited | Composiciones que comprenden conjugados de peg-interferón alfa y rafinosa como crioprotector. |
| AU2013204652B2 (en) * | 2007-04-26 | 2015-06-18 | Bayer Healthcare Llc | Stabilization of liquid solutions of recombinant protein for frozen storage |
| EP2150264A4 (en) | 2007-04-26 | 2014-09-24 | Bayer Healthcare Llc | STABILIZATION OF LIQUID SOLUTIONS OF A RECOMBINANT PROTEIN FOR FROZEN STORAGE |
| WO2008139945A1 (ja) * | 2007-05-08 | 2008-11-20 | Ajinomoto Co., Inc. | 低脂肪食品 |
| US9101691B2 (en) | 2007-06-11 | 2015-08-11 | Edwards Lifesciences Corporation | Methods for pre-stressing and capping bioprosthetic tissue |
| JP5552046B2 (ja) * | 2007-06-13 | 2014-07-16 | ノボ・ノルデイスク・エー/エス | インスリン誘導体を含有する薬学的製剤 |
| GB0715285D0 (en) * | 2007-08-06 | 2007-09-12 | Britannia Pharmaceuticals Ltd | Improvements in or relating to powdered medicaments for nasal delivery |
| CN101376022B (zh) * | 2007-08-31 | 2011-11-30 | 上海医药工业研究院 | 含聚乙二醇降纤酶的药物组合物 |
| WO2009082648A1 (en) * | 2007-12-21 | 2009-07-02 | Inspiration Biopharmaceuticals, Inc. | Stabilized factor ix formulations containing trehalose |
| US8357387B2 (en) | 2007-12-21 | 2013-01-22 | Edwards Lifesciences Corporation | Capping bioprosthetic tissue to reduce calcification |
| SI2574677T1 (sl) | 2007-12-27 | 2017-11-30 | Baxalta GmbH | Procesi celične kulture |
| EP2113564A1 (en) * | 2008-05-01 | 2009-11-04 | Arecor Limited | Protein formulation |
| JP5785077B2 (ja) * | 2008-08-05 | 2015-09-24 | ワイス・エルエルシー | 崩壊温度より高温での凍結乾燥 |
| WO2010020690A1 (en) | 2008-08-21 | 2010-02-25 | Octapharma Ag | Recombinantly produced human factor viii and ix |
| WO2010027766A1 (en) * | 2008-08-27 | 2010-03-11 | Schering Corporation | Lyophilized formulatons of engineered anti-il-23p19 antibodies |
| KR101691070B1 (ko) * | 2008-09-03 | 2016-12-29 | 옥타파마 아게 | 재조합에 의해 제조된 인자 ⅷ을 위한 신규한 보호 조성물 |
| EP2684570A1 (en) * | 2008-09-10 | 2014-01-15 | F. Hoffmann-La Roche AG | Compositions and methods for the prevention of oxidative degradation of proteins |
| CN102202683A (zh) * | 2008-10-30 | 2011-09-28 | 诺沃-诺迪斯克有限公司 | 用少于每日一次的注射频率注射胰岛素来治疗糖尿病 |
| EP2385825B1 (en) * | 2008-11-07 | 2018-10-10 | University of Connecticut | Factor viii formulations |
| EP2248518B1 (en) | 2009-04-17 | 2013-01-16 | Merz Pharma GmbH & Co. KGaA | Formulation for stabilizing proteins, peptides or mixtures thereof. |
| US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| RU2744370C2 (ru) | 2009-07-27 | 2021-03-05 | Баксалта Инкорпорейтед | Конъюгаты белков свертывания крови |
| EP3081233B1 (en) | 2009-07-27 | 2020-12-23 | Baxalta GmbH | Glycopolysialylation of proteins other than blood coagulation proteins |
| US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
| BR112012001814A8 (pt) | 2009-07-27 | 2018-02-06 | Baxalta GmbH | Conjugados de proteína de coagulação sanguínea |
| GB0915480D0 (en) * | 2009-09-04 | 2009-10-07 | Arecor Ltd | Stable formulation of factor viii |
| EP4218797B9 (en) | 2009-09-21 | 2025-04-30 | Takeda Pharmaceutical Company Limited | Stabilized liquid and lyophilized adamts13 formulations |
| CN102655876B (zh) | 2009-11-03 | 2015-07-15 | 基立福疗法公司 | α-1蛋白酶抑制剂组合物、方法和试剂盒 |
| BR112012012460B1 (pt) | 2009-11-24 | 2020-06-23 | Grifols Therapeutics Inc. | Método de liofilização de uma composição |
| RU2682720C2 (ru) * | 2010-01-19 | 2019-03-21 | Ханми Сайенс Ко., Лтд. | Жидкие составы для конъюгата эритропоэтина длительного действия |
| BR122014006876B1 (pt) | 2010-03-23 | 2020-09-29 | Edwards Lifesciences Corporation | Método para preparar material de membrana de tecido bioprotético |
| US8906601B2 (en) | 2010-06-17 | 2014-12-09 | Edwardss Lifesciences Corporation | Methods for stabilizing a bioprosthetic tissue by chemical modification of antigenic carbohydrates |
| CN102946916B (zh) | 2010-06-17 | 2015-03-18 | 爱德华兹生命科学公司 | 通过化学修饰抗原性碳水化合物稳定生物假体组织的方法 |
| PL2616090T3 (pl) * | 2010-09-17 | 2023-12-18 | Takeda Pharmaceutical Company Limited | Stabilizowanie immunoglobulin poprzez wodną formulację z histydyną o ph od słabo kwaśnego do obojętnego |
| JP5990176B2 (ja) * | 2010-10-12 | 2016-09-07 | メルツ ファーマ ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディト ゲゼルシャフト アウフ アクティーン | タンパク質の安定化に好適な哺乳動物性賦形剤非含有製剤 |
| DK2632478T3 (da) | 2010-10-27 | 2019-10-07 | Novo Nordisk As | Behandling af diabetes melitus under anvendelse af insulinindsprøjtninger indgivet med varierende indsprøjtningsintervaller |
| BR112013011041B1 (pt) | 2010-11-05 | 2021-05-25 | Baxalta GmbH | variante de fator viii, método para produzir uma variante de fviii, uso da variante de fator viii, e, composição farmacêutica |
| US9351829B2 (en) | 2010-11-17 | 2016-05-31 | Edwards Lifesciences Corporation | Double cross-linkage process to enhance post-implantation bioprosthetic tissue durability |
| WO2012079979A1 (en) * | 2010-12-16 | 2012-06-21 | Novo Nordisk A/S | Aqueous factor viii solution |
| ES2800983T3 (es) | 2010-12-22 | 2021-01-07 | Baxalta GmbH | Materiales y métodos para conjugar un derivado de ácido graso soluble en agua con una proteína |
| BRPI1105317A2 (pt) | 2011-01-24 | 2013-04-30 | Fundacco Hemoct De Ribeirco Preto | produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1 |
| WO2012135408A1 (en) | 2011-03-31 | 2012-10-04 | Merck Sharp & Dohme Corp. | Stable formulations of antibodies to human programmed death receptor pd-1 and related treatments |
| US8916352B2 (en) | 2011-04-08 | 2014-12-23 | Bio-Rad Laboratories, Inc. | PCR reaction mixtures with decreased non-specific activity |
| CN103562410B (zh) | 2011-04-08 | 2016-09-28 | 伯乐实验室公司 | 具有降低的非特异性活性的sso7-聚合酶缀合物 |
| WO2014031718A1 (en) | 2012-08-23 | 2014-02-27 | Merck Sharp & Dohme Corp. | Stable formulations of antibodies to tslp |
| US10238771B2 (en) | 2012-11-08 | 2019-03-26 | Edwards Lifesciences Corporation | Methods for treating bioprosthetic tissue using a nucleophile/electrophile in a catalytic system |
| UA117466C2 (uk) | 2012-12-13 | 2018-08-10 | Мерк Шарп Енд Доме Корп. | СТАБІЛЬНИЙ СКЛАД У ВИГЛЯДІ РОЗЧИНУ АНТИТІЛА ДО IL-23p19 |
| AU2014237111B2 (en) * | 2013-03-15 | 2018-06-21 | Bayer Healthcare Llc | Recombinant factor VIII formulations |
| ES2926798T3 (es) * | 2013-03-15 | 2022-10-28 | Bioverativ Therapeutics Inc | Formulaciones de polipéptido de factor VIII |
| US9839579B2 (en) | 2013-04-24 | 2017-12-12 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| US9700486B2 (en) | 2013-04-24 | 2017-07-11 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
| EP2991672A1 (en) | 2013-04-30 | 2016-03-09 | Novo Nordisk A/S | Novel administration regime |
| KR102058864B1 (ko) | 2013-12-16 | 2019-12-24 | 주식회사 티움바이오 | 인자 vii의 융합 단백질을 포함하는 안정성이 개선된 약학적 조성물 |
| CN106456720A (zh) | 2014-04-01 | 2017-02-22 | 爱德技术生物科学有限公司 | 在无钙作为赋形剂下因子viii的稳定性 |
| US9907835B2 (en) | 2014-04-01 | 2018-03-06 | Advanced Bioscience Farmacêutica LTDA | Stable Factor VIII formulations with low sugar-glycine |
| JP6516829B2 (ja) | 2014-08-04 | 2019-05-22 | シーエスエル、リミテッド | 第viii因子製剤 |
| KR20250150675A (ko) * | 2014-08-20 | 2025-10-20 | 포톨라 파마슈티컬스, 인코포레이티드 | 인자 xa 해독제용 동결건조된 제형 |
| SG11201702757YA (en) * | 2014-10-23 | 2017-05-30 | Ngm Biopharmaceuticals Inc | Pharmaceutical compositions comprising peptide variants and methods of use thereof |
| US11077193B2 (en) | 2015-04-21 | 2021-08-03 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Nerve growth factor composition and powder injection |
| EP3287139B1 (en) | 2015-04-21 | 2021-08-11 | Staidson (Beijing) Biopharmaceuticals Co., Ltd. | Nerve growth factor composition and injection powder |
| US11173197B2 (en) | 2015-07-07 | 2021-11-16 | Bluewillow Biologics, Inc. | Methods and compositions for nanoemulsion vaccine formulations |
| EP3319930A4 (en) * | 2015-07-07 | 2019-04-10 | NanoBio Corporation | METHOD AND COMPOSITIONS FOR STABILIZING PROTEINS |
| US10287338B2 (en) | 2015-07-10 | 2019-05-14 | Miran NERSISSIAN | Factor VIII protein compositions and methods of treating of hemophilia A |
| EP3167877A1 (en) * | 2015-11-12 | 2017-05-17 | Bayer Pharma Aktiengesellschaft | Method for the production of freeze-dried pellets comprising factor viii |
| CN108883160B (zh) | 2016-02-24 | 2022-06-28 | 博尔托拉制药公司 | 因子xa解毒剂的冻干制剂 |
| DK3463308T4 (da) * | 2016-06-01 | 2026-02-09 | Servier Ip Uk Ltd | Formuleringer af polyalkylenoxid-asparaginase og fremgangsmåder til fremstilling og anvendelse deraf |
| WO2018112780A1 (en) * | 2016-12-21 | 2018-06-28 | Chung Chin Sun | Novel method for blood plasma protein activity preservation |
| JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
| CN110913906A (zh) | 2017-05-02 | 2020-03-24 | 默沙东公司 | 抗lag3抗体的制剂和抗lag3抗体与抗pd-1抗体的共制剂 |
| CA3060695A1 (en) | 2017-05-02 | 2018-11-08 | Merck Sharp & Dohme Corp. | Stable formulations of anti-ctla4 antibodies alone and in combination with programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
| JP6630315B2 (ja) | 2017-06-27 | 2020-01-15 | 矢崎総業株式会社 | ノイズ低減ユニット |
| US10335464B1 (en) | 2018-06-26 | 2019-07-02 | Novo Nordisk A/S | Device for titrating basal insulin |
| MX2021004356A (es) | 2018-10-18 | 2021-05-31 | Merck Sharp & Dohme Llc | Formulaciones de anticuerpos anti-rsv y metodos de uso de las mismas. |
| MA54089A (fr) | 2018-10-31 | 2022-02-09 | Merck Sharp & Dohme | Anticorps anti-pd-1 humain et procédés d'utilisation associés |
| JP7503056B6 (ja) | 2018-11-07 | 2024-07-16 | メルク・シャープ・アンド・ドーム・エルエルシー | 抗lag3抗体および抗pd-1抗体の共-製剤 |
| MX2021008017A (es) * | 2019-01-06 | 2021-08-05 | Endo Global Aesthetics Ltd | Formulaciones de colagenasa y metodos de produccion de las mismas. |
| WO2021001522A1 (en) | 2019-07-04 | 2021-01-07 | CSL Behring Lengnau AG | A truncated von willebrand factor (vwf) for increasing the in vitro stability of coagulation factor viii |
| CN114096269B (zh) | 2019-07-12 | 2024-06-11 | 诺和诺德股份有限公司 | 高浓度胰岛素制剂 |
| CN110772487B (zh) * | 2019-12-09 | 2021-09-21 | 湖南科伦制药有限公司 | 一种二乙酰氨乙酸乙二胺的冻干方法 |
| CN112121009B (zh) * | 2020-09-24 | 2022-12-02 | 科兴生物制药股份有限公司 | 一种聚乙二醇修饰重组人粒细胞刺激因子新制剂 |
| US20230365692A1 (en) | 2020-09-24 | 2023-11-16 | Merck Sharp & Dohme Llc | Stable formulations of programmed death receptor 1 (pd-1) antibodies and hyaluronidase variants and fragments thereof and methods of use thereof |
| EP4240757A2 (en) | 2020-11-09 | 2023-09-13 | Takeda Pharmaceutical Company Limited | Purification of fviii from plasma using silicon oxide adsorption |
| US20230030281A1 (en) * | 2021-04-09 | 2023-02-02 | Hyalo Technologies, LLC | Method of sterilization of biologics |
| US20220323621A1 (en) * | 2021-04-09 | 2022-10-13 | Hyalo Technologies, LLC | Method of sterilization of biologics |
| WO2023017020A1 (en) * | 2021-08-11 | 2023-02-16 | Grifols Worldwide Operations Limited | Method for producing human plasma-derived factor viii / von willebrand factor and composition obtained |
| CN114015758B (zh) * | 2021-10-15 | 2022-06-24 | 无锡百泰克生物技术有限公司 | 一种冻干保护剂、荧光pcr检测试剂盒及冻干工艺 |
Family Cites Families (181)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB941019A (en) | 1961-04-27 | 1963-11-06 | Crookes Lab Ltd | Improvements in and relating to the stability of anti-haemophilic globulin (factor viii) |
| US3389314A (en) | 1962-05-07 | 1968-06-18 | Penn Controls | Proportional silicon controlled rectifier driven system for a heat motor |
| US3681126A (en) | 1969-11-25 | 1972-08-01 | Monsanto Co | Flame retardant article containing tris-(3 - halo - 2-hydroxypropyl)-hydroxymethylphosphonium chloride |
| US3839314A (en) * | 1971-06-29 | 1974-10-01 | Baxter Laboratories Inc | Clarification of blood serum and plasma using block copolymers of ethylene oxide and polyoxypropylene |
| US3770631A (en) | 1971-06-29 | 1973-11-06 | Baxter Laboratories Inc | Clarification of blood serum and plasma |
| US4073886A (en) | 1973-01-30 | 1978-02-14 | Baxter Travenol Laboratories, Inc. | Blood fractionation process using block copolymers of ethylene oxide and polyoxypropylene |
| US3980432A (en) | 1973-04-02 | 1976-09-14 | Behringwerke Aktiengesellschaft | Partial thromboplastin, its use as diagnostic agent and process for preparing it |
| US3893991A (en) | 1973-04-05 | 1975-07-08 | Baxter Laboratories Inc | Clarification of blood serum and plasma using block copolymers of ethylene oxide and polyoxypropylene |
| US3893990A (en) | 1973-04-05 | 1975-07-08 | Baxter Laboratories Inc | Clarification of blood serum and plasma using a block copolymer of ethylene oxide and polyoxypropylene |
| US4086218A (en) | 1975-04-11 | 1978-04-25 | Edward Shanbrom, Inc. | Method of preserving blood plasma II |
| US4189425A (en) | 1975-04-11 | 1980-02-19 | Edward Shanbrom, Inc. | Method of preserving blood plasma I |
| US4069216A (en) | 1975-06-16 | 1978-01-17 | Edward Shanbrom, Inc. | Simplified methods for preparation of very high purity Factor VIII concentrate |
| US4089944A (en) | 1975-12-22 | 1978-05-16 | Baxter Travenol Laboratories, Inc. | Rapidly solubilized AHF composition and process for preparing same |
| US4027013A (en) | 1976-01-22 | 1977-05-31 | William L. Wilson | Clottable fibrinogen free factor VIII and albumin product and process |
| SU663404A1 (ru) | 1976-12-30 | 1979-05-25 | Московский Ордена Ленина И Ордена Трудового Красного Знамени Государственный Университет Им. М.В.Ломоносова | Способ получени фибрин-мономера |
| US4137223A (en) | 1977-05-16 | 1979-01-30 | Edward Shanbrom, Inc. | Method of preserving blood plasma II |
| SE443293B (sv) | 1978-01-25 | 1986-02-24 | Blombaeck E G B | Blodfraktionsframstellning |
| DE2916711A1 (de) | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
| US4783441A (en) | 1979-04-30 | 1988-11-08 | Hoechst Aktiengesellschaft | Aqueous protein solutions stable to denaturation |
| FR2460305A2 (fr) | 1979-06-29 | 1981-01-23 | Merieux Inst | Procede de preparation d'un concentre de facteur viii |
| US4386068A (en) | 1980-02-26 | 1983-05-31 | Cutter Laboratories, Inc. | Antihemophilic factor concentrate and method for preparation |
| JPS56127308U (enExample) | 1980-02-27 | 1981-09-28 | ||
| US4623717A (en) | 1980-03-05 | 1986-11-18 | Miles Laboratories, Inc. | Pasteurized therapeutically active protein compositions |
| US4341764A (en) | 1980-03-05 | 1982-07-27 | Cutter Laboratories, Inc. | Method of preparing fibronectin and antihemophilic factor |
| DE3176491D1 (en) | 1980-03-05 | 1987-11-26 | Miles Lab | Pasteurized therapeutically active protein compositions |
| US4440679A (en) | 1980-03-05 | 1984-04-03 | Cutter Laboratories, Inc. | Pasteurized therapeutically active protein compositions |
| JPS56127308A (en) | 1980-03-11 | 1981-10-06 | Green Cross Corp:The | Blood-coagulation factor 8 pharmaceutical |
| JPS56135418A (en) | 1980-03-27 | 1981-10-22 | Green Cross Corp:The | Heat treatment of aqueous solution containing 8 factor of coagulation of blood derived from human |
| AT369263B (de) | 1980-08-27 | 1982-12-27 | Immuno Ag | Verfahren zur herstellung eines faktor viii(ahf) -hochkonzentrates |
| DE3033932C2 (de) | 1980-09-10 | 1984-05-24 | Biotest-Serum-Institut Gmbh, 6000 Frankfurt | Verfahren zur Kaltsterilisation von Blutgerinnungsfaktor VIII enthaltenden Präparaten |
| JPS5770814A (en) | 1980-10-17 | 1982-05-01 | Isamu Horikoshi | Oral preparation of blood clotting eighth factor |
| JPS6122022Y2 (enExample) | 1981-01-10 | 1986-07-02 | ||
| US4495278A (en) | 1981-04-27 | 1985-01-22 | Baxter Travenol Laboratories, Inc. | Process for making novel blood clotting enzyme compositions |
| US4382083A (en) | 1981-06-25 | 1983-05-03 | Baxter Travenol Laboratories, Inc. | Therapeutic method for treating blood-clotting defects with factor VIIa |
| US4479938A (en) | 1981-06-25 | 1984-10-30 | Baxter Travenol Laboratories, Inc. | Therapeutic composition containing factor VIIa |
| JPS5874617A (ja) | 1981-10-28 | 1983-05-06 | Green Cross Corp:The | 人由来血液凝固第7因子含有水溶液の加熱処理方法 |
| US4456590B2 (en) | 1981-11-02 | 1989-05-30 | Heat treatment of lyphilized blood clotting factor viii concentrate | |
| US4591505A (en) | 1982-04-14 | 1986-05-27 | New York Blood Center, Inc. | Process for inactivating hepatitis B virus |
| US4481189A (en) | 1982-04-14 | 1984-11-06 | New York Blood Center Inc. | Process for preparing sterilized plasma and plasma derivatives |
| US4495175A (en) | 1982-08-05 | 1985-01-22 | University Of Rochester | Preparation of highly purified human antihemophilic factor |
| DE3230849A1 (de) | 1982-08-19 | 1984-02-23 | Behringwerke Ag, 3550 Marburg | Pasteurisiertes human-fibrinogen (hf) und verfahren zu dessen herstellung |
| DE3237512A1 (de) | 1982-10-09 | 1984-04-12 | Behringwerke Ag, 3550 Marburg | Verfahren zur pasteurisierung von antihaemophilem kryopraezipitat (ahk) und danach hergestelltes antihaemophiles kryopraezipitat |
| GB2129685B (en) | 1982-11-11 | 1985-11-13 | Nat Biolog Standards Board | Anti-haemophilic compositions |
| JPS59134730A (ja) | 1983-01-20 | 1984-08-02 | Green Cross Corp:The | 血液凝固第8因子の加熱処理法 |
| US4650858A (en) | 1983-03-21 | 1987-03-17 | Nordisk Gentofte A/S | Concentrate of the antihemophilic factor VIII and a process for producing it |
| IE80858B1 (en) | 1983-03-31 | 1999-04-21 | Scripps Research Inst | New factor viii coagulant polypeptides |
| US4748120A (en) | 1983-05-02 | 1988-05-31 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
| US4727027A (en) | 1983-05-02 | 1988-02-23 | Diamond Scientific Co. | Photochemical decontamination treatment of whole blood or blood components |
| AT379510B (de) | 1983-05-20 | 1986-01-27 | Immuno Ag | Verfahren zur herstellung einer faktor viii (ahf) -haeltigen praeparation |
| DE3318521A1 (de) | 1983-05-20 | 1984-11-22 | Lentia GmbH Chem. u. pharm. Erzeugnisse - Industriebedarf, 8000 München | Verfahren zur herstellung eines antihaemophiliefaktor-konzentrats |
| US4540573A (en) | 1983-07-14 | 1985-09-10 | New York Blood Center, Inc. | Undenatured virus-free biologically active protein derivatives |
| DE3336631A1 (de) | 1983-10-08 | 1985-04-18 | Behringwerke Ag, 3550 Marburg | Verfahren zur pasteurisierung von plasma oder von konzentraten der blutgerinnungsfaktoren ii, vii, ix und x |
| US4757006A (en) | 1983-10-28 | 1988-07-12 | Genetics Institute, Inc. | Human factor VIII:C gene and recombinant methods for production |
| US4693981A (en) | 1983-12-20 | 1987-09-15 | Advanced Genetics Research Institute | Preparation of inactivated viral vaccines |
| JPS6122022A (ja) | 1983-12-28 | 1986-01-30 | Green Cross Corp:The | 血漿蛋白の加熱処理方法 |
| DE10399009I1 (de) | 1984-01-12 | 2003-10-23 | Chiron Corp | F}r Faktor-VIIIc kodierende DNA-Sequenzen und verwandte DNA-Konstruktionen |
| AT389815B (de) | 1984-03-09 | 1990-02-12 | Immuno Ag | Verfahren zur inaktivierung von vermehrungsfaehigen filtrierbaren krankheitserregern in blutprodukten |
| US4831012A (en) | 1984-03-23 | 1989-05-16 | Baxter International Inc. | Purified hemoglobin solutions and method for making same |
| JPS60199829A (ja) | 1984-03-24 | 1985-10-09 | Nippon Sekijiyuujishiya | 高純度抗血友病グロブリンの製造方法 |
| US5043428A (en) | 1984-08-31 | 1991-08-27 | Behringwerke Aktiengesellschaft | Pasteurized, isoagglutinin-free factor VIII preparation and a process for its production |
| US4543210A (en) | 1984-10-04 | 1985-09-24 | Miles Laboratories, Inc. | Process for producing a high purity antihemophilic factor concentrate |
| US4613501A (en) | 1984-12-21 | 1986-09-23 | New York Blood Center, Inc. | Inactivation of viruses in labile blood derivatives |
| JPS61271222A (ja) * | 1985-05-24 | 1986-12-01 | Dainippon Pharmaceut Co Ltd | ヒトインターロイキン1ポリペプチド及びその製造法 |
| US4847362A (en) | 1985-02-01 | 1989-07-11 | New York University | Method for purifying antihemophilic factor |
| US4952675A (en) | 1985-02-01 | 1990-08-28 | New York University | Method for purifying antihemophilic factor |
| US4743680A (en) | 1985-02-01 | 1988-05-10 | New York University | Method for purifying antihemophilic factor |
| MX9203440A (es) | 1985-04-12 | 1992-07-01 | Genetics Inst | Proteinas procoagulantes novedosas. |
| JPH0779694B2 (ja) | 1985-07-09 | 1995-08-30 | カドラント バイオリソ−シズ リミテツド | 蛋白質および同類品の保護 |
| US4758657A (en) | 1985-07-11 | 1988-07-19 | Armour Pharmaceutical Company | Method of purifying Factor VIII:C |
| ATE52922T1 (de) | 1985-08-05 | 1990-06-15 | Immuno Ag | Verfahren zur herstellung von praeparationen auf basis von blutgerinnungsfaktoren. |
| CA1293941C (en) | 1985-11-08 | 1992-01-07 | Maria Erlinda Co-Sarno | Method for preparing antihemophilic factor (ahf) by cold precipitation and for improving solubility of recovered ahf product |
| US5180583A (en) | 1985-11-26 | 1993-01-19 | Hedner Ulla K E | Method for the treatment of bleeding disorders |
| JPS62195331A (ja) | 1986-02-24 | 1987-08-28 | Nippon Sekijiyuujishiya | 血液凝固第8因子製剤の製法 |
| AT390374B (de) | 1986-03-18 | 1990-04-25 | Schwab & Co Gmbh | Verfahren zum pasteurisieren von plasmaprotein und plasmaproteinfraktionen |
| DE3609431A1 (de) | 1986-03-20 | 1987-09-24 | Biotest Pharma Gmbh | Verfahren zur herstellung eines den blutgerinnungsfaktor viii enthaltenden, sterilen praeparates |
| JPH0441740Y2 (enExample) | 1986-05-30 | 1992-09-30 | ||
| US4841023A (en) | 1986-06-25 | 1989-06-20 | New York Blood Center, Inc. | Inactivation of viruses in labile protein-containing compositions using fatty acids |
| AT391808B (de) | 1986-11-03 | 1990-12-10 | Immuno Ag | Verfahren zur herstellung einer faktor viii (ahf)-haeltigen fraktion |
| GB8628104D0 (en) | 1986-11-25 | 1986-12-31 | Connaught Lab | Pasteurization of immunoglobin solutions |
| CA1331157C (en) | 1987-04-06 | 1994-08-02 | Randal J. Kaufman | Method for producing factor viii:c-type proteins |
| ES2006632A6 (es) | 1987-04-21 | 1989-05-01 | Green Cross Corp | Procedimiento de tratamiento termico de fibrinogeno. |
| IL86417A (en) | 1987-05-22 | 1992-09-06 | Armour Pharma | Process for the inactivation of pathogens in biological or pharmaceutical material by mixing with aqueous solution containing a sugar(alcohol)and neutral salts as stabilizers |
| US4876241A (en) | 1987-05-22 | 1989-10-24 | Armour Pharmaceutical Company | Stabilization of biological and pharmaceutical products during thermal inactivation of viral and bacterial contaminants |
| US4795806A (en) | 1987-07-16 | 1989-01-03 | Miles Laboratories, Inc. | Phospholipid affinity purification of Factor VIII:C |
| JPH0387173A (ja) | 1987-09-10 | 1991-04-11 | Teijin Ltd | ヒト活性化天然型ファクター8cの製造方法及びそれに用いる形質転換体 |
| DE3730533A1 (de) | 1987-09-11 | 1989-03-30 | Biotest Pharma Gmbh | Verfahren zur sterilisation von plasma oder plasmafraktionen |
| KR890004724A (ko) * | 1987-09-17 | 1989-05-09 | 히사시 미하라 | 신규 프로테아제 제제(製劑) |
| US5605884A (en) | 1987-10-29 | 1997-02-25 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Factor VIII formulations in high ionic strength media |
| CA1329760C (en) * | 1987-10-29 | 1994-05-24 | Ted C. K. Lee | Plasma and recombinant protein formulations in high ionic strength media |
| US4877608A (en) | 1987-11-09 | 1989-10-31 | Rorer Pharmaceutical Corporation | Pharmaceutical plasma protein formulations in low ionic strength media |
| US5177191A (en) | 1987-12-21 | 1993-01-05 | Miles, Inc. | Gel filtration of factor VIII |
| DK18288D0 (da) | 1988-01-15 | 1988-01-15 | Nordisk Gentofte | Fremgangsmaade til pasteurisering af vandige oploesninger af faktor viii |
| WO1989009784A1 (en) | 1988-04-08 | 1989-10-19 | Commonwealth Serum Laboratories Commission | Production of heat-stable factor viii concentrate |
| US4981951A (en) | 1988-04-14 | 1991-01-01 | Miles Inc. | Lectin affinity chromatography of factor VIII |
| FR2632309B1 (fr) | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
| US5047249A (en) | 1988-07-22 | 1991-09-10 | John Morris Co., Inc. | Compositions and methods for treating skin conditions and promoting wound healing |
| US5051353A (en) | 1988-08-09 | 1991-09-24 | The United States Of America As Represented By The Secretary Of The Navy | Preservation and restoration of hemoglobin in blood substitutes |
| JPH02157231A (ja) * | 1988-12-07 | 1990-06-18 | Bio Kagaku Kenkyusho:Kk | 細胞増殖抑制剤 |
| DE3904354A1 (de) | 1989-02-14 | 1990-08-16 | Behringwerke Ag | Pasteurisiertes, gereinigtes von willebrand-faktor-konzentrat und verfahren zu seiner herstellung |
| FR2665449B1 (fr) | 1990-08-02 | 1995-04-14 | Aquitaine Developp Transf Sang | Procede de fabrication de facteur von willebrand ayant une tres haute purete, depourvu en majeure partie de facteur antihemophilique (fviiic), et facteur von willebrand ainsi obtenu, ainsi qu'une composition pharmaceutique le contenant. |
| US5760183A (en) | 1989-02-17 | 1998-06-02 | Association D'aquitaine Pour De Developpment De La Transfusion Sanguine Et Des Recherches Hematologiques | Process for the manufacture of very high-purity antithaemophilic factor (FVIIIC), and von Willebrand factor, and pharmaceutical compositions containing same |
| CN1047342A (zh) | 1989-05-13 | 1990-11-28 | 杭州市中心血站 | 因子viii的生产及其病毒灭活方法 |
| DK0399321T3 (da) | 1989-05-24 | 1993-08-09 | Miles Inc | Gelfiltrering af varmebehandlet faktor VIII |
| GB8913183D0 (en) * | 1989-06-08 | 1989-07-26 | Central Blood Lab Authority | Chemical products |
| US5138034A (en) | 1989-07-12 | 1992-08-11 | The Green Cross Corporation | Method of fractionating plasma proteins |
| US5062498A (en) | 1989-07-18 | 1991-11-05 | Jaromir Tobias | Hydrostatic power transfer system with isolating accumulator |
| DE69029765T2 (de) | 1989-07-24 | 1997-05-15 | Bayer Ag | Stabilisierung von hochgereinigten Proteinen |
| DE3926034C3 (de) | 1989-08-07 | 1996-11-21 | Behringwerke Ag | Verfahren zur Herstellung eines stabilen Faktors VIII |
| FR2651437A1 (fr) | 1989-09-05 | 1991-03-08 | Lille Transfusion Sanguine | Procede de preparation de concentre du complexe facteur viii-facteur von willebrand de la coagulation sanguine a partir de plasma total. |
| DK162233C (da) | 1989-11-09 | 1992-03-16 | Novo Nordisk As | Fremgangsmaade til isolering af faktor viii fra blodplasma og pharmaceutisk praeparat indeholdende den saaledes isolerede fator viii |
| SE465222C5 (sv) | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
| US5439882A (en) | 1989-12-29 | 1995-08-08 | Texas Tech University Health Sciences Center | Blood substitute |
| DE4001451A1 (de) | 1990-01-19 | 1991-08-01 | Octapharma Ag | Stabile injizierbare loesungen von faktor viii und faktor ix |
| US5798238A (en) | 1990-04-16 | 1998-08-25 | Baxter International Inc. | Method of inactivation of viral and bacterial blood contaminants with quinolines as photosensitizer |
| US5418130A (en) | 1990-04-16 | 1995-05-23 | Cryopharm Corporation | Method of inactivation of viral and bacterial blood contaminants |
| US5587490A (en) | 1990-04-16 | 1996-12-24 | Credit Managers Association Of California | Method of inactivation of viral and bacterial blood contaminants |
| WO1991017194A1 (en) * | 1990-05-07 | 1991-11-14 | Exxon Chemical Patents Inc. | UNSATURATED α-OLEFIN COPOLYMERS AND METHOD FOR PREPARATION THEREOF |
| US5378612A (en) | 1990-05-11 | 1995-01-03 | Juridical Foundation The Chemo-Sero-Therapeutic Research Institute | Culture medium for production of recombinant protein |
| US5232844A (en) | 1990-05-15 | 1993-08-03 | New York Blood Center | Photodynamic inactivation of viruses in cell-containing compositions |
| US5712086A (en) | 1990-05-15 | 1998-01-27 | New York Blood Center, Inc. | Process for transfusing cell containing fractions sterilized with radiation and a quencher of type I and type II photodynamic reactions |
| FR2662166A1 (fr) | 1990-05-18 | 1991-11-22 | Fondation Nale Transfusion San | Procede de preparation de facteur viii de tres haute purete comprenant une etape rapide d'immunoadsorption. |
| IT1248723B (it) | 1990-06-12 | 1995-01-26 | Scalvo S P A | Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo |
| EP0491895B1 (en) | 1990-07-12 | 1995-07-19 | Dade Produktions AG | FACTOR VIII:Ca CHROMOGENIC ASSAY |
| AU650045B2 (en) | 1990-09-12 | 1994-06-09 | Lifecell Corporation | Method and apparatus for cryopreparation dry stabilization and rehydration of biological suspensions |
| US5272135A (en) | 1991-03-01 | 1993-12-21 | Chiron Ophthalmics, Inc. | Method for the stabilization of methionine-containing polypeptides |
| FR2673632A1 (fr) | 1991-03-08 | 1992-09-11 | Lille Transfusion Sanguine | Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique. |
| DE4111393A1 (de) | 1991-04-09 | 1992-10-15 | Behringwerke Ag | Stabilisierte faktor viii-praeparationen |
| SE468480B (sv) | 1991-05-24 | 1993-01-25 | Arne Holmgren | Modifierat tioredoxin och dess anvaendning |
| AU2309692A (en) | 1991-07-03 | 1993-02-11 | Cryolife, Inc. | Method for stabilization of biomaterials |
| US5254350A (en) | 1991-07-22 | 1993-10-19 | Helena Laboratories Corporation | Method of preparing a thromboplastin extract |
| CA2078721A1 (en) | 1991-09-24 | 1993-03-25 | Hiroshi Yonemura | Process for preparing human coagulation factor viii protein complex |
| FR2681867B1 (fr) | 1991-09-26 | 1993-12-31 | Pasteur Merieux Serums Vaccins | Procede de purification du facteur viii et preparations obtenues. |
| US5278289A (en) | 1991-11-12 | 1994-01-11 | Johnson Alan J | Antihemophilic factor stabilization |
| US5192743A (en) | 1992-01-16 | 1993-03-09 | Genentech, Inc. | Reconstitutable lyophilized protein formulation |
| JPH05331071A (ja) * | 1992-01-17 | 1993-12-14 | Asahi Chem Ind Co Ltd | カルシトニン遺伝子関連ペプチド類の凍結乾燥組成物および安定化法 |
| AT399818B (de) | 1992-04-24 | 1995-07-25 | Immuno Ag | Verfahren zur herstellung einer hochgereinigten virussicheren faktor viii-präparation |
| US5288853A (en) | 1992-04-30 | 1994-02-22 | Alpha Therapeutic Corporation | Factor viii purification process |
| WO1993022336A1 (en) | 1992-04-30 | 1993-11-11 | Alpha Therapeutic Corporation | Improved solubilization and stabilization of factor viii complex |
| US5378601A (en) | 1992-07-24 | 1995-01-03 | Montefiore Medical Center | Method of preserving platelets with apyrase and an antioxidant |
| US5424471A (en) * | 1992-07-31 | 1995-06-13 | U.S. Bioscience, Inc. | Crystalline amifostine compositions and methods of the preparation and use of same |
| SE9302006D0 (sv) * | 1992-10-02 | 1993-06-11 | Kabi Pharmacia Ab | Protein formulation |
| ATE198277T1 (de) * | 1992-10-02 | 2001-01-15 | Genetics Inst | Zusammensetzung, welche den koagulationsfaktor viii beinhaltet; verfahren zu deren herstellung und die benutzung eines oberflächenaktiven stoffes als stabilisator |
| IT1256622B (it) | 1992-12-04 | 1995-12-12 | Sclavo Spa | Processo per l'estrazione del complesso fattore viii-fattore von willebrand (fviii:c-fvw) da plasma umano totale. |
| DE4242863A1 (de) * | 1992-12-18 | 1994-06-23 | Boehringer Mannheim Gmbh | Stabile lyophilisierte pharmazeutische Zubereitungen von G-CSF |
| ES2118386T3 (es) | 1993-02-09 | 1998-09-16 | Octapharma Ag | Procedimiento para la inactivacion de virus que no estan provistos de envolventes lipidicas. |
| SE9301581D0 (sv) * | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Protein formulation |
| SE504074C2 (sv) | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
| US5576291A (en) | 1993-09-13 | 1996-11-19 | Baxter International Inc. | Activated factor VIII as a therapeutic agent and method of treating factor VIII deficiency |
| US5353835A (en) | 1993-09-23 | 1994-10-11 | Ingersoll-Rand Company | Air tank drain |
| IT1268920B1 (it) | 1994-03-29 | 1997-03-13 | Syfal Srl | Macchina rotativa per la decorazione-smaltatura in particolare dipiastrelle ceramiche. |
| IL113010A0 (en) | 1994-03-31 | 1995-10-31 | Pharmacia Ab | Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
| US5514781A (en) | 1994-04-11 | 1996-05-07 | Bayer Corporation | Use of azoles as virucidal agents in solutions of biologically active proteins |
| US5955448A (en) | 1994-08-19 | 1999-09-21 | Quadrant Holdings Cambridge Limited | Method for stabilization of biological substances during drying and subsequent storage and compositions thereof |
| FR2719479B1 (fr) * | 1994-05-04 | 1996-07-26 | Sanofi Elf | Formulation stable lyophilisée comprenant une protéine: kit de dosage. |
| JP4142095B2 (ja) | 1994-06-02 | 2008-08-27 | クアドラント・ドラツグ・デリバリー・リミテツド | 各種物質の再水和または融解時の凝集を防止する方法及び該方法により得られる組成物 |
| US5580856A (en) | 1994-07-15 | 1996-12-03 | Prestrelski; Steven J. | Formulation of a reconstituted protein, and method and kit for the production thereof |
| DE4431833C1 (de) | 1994-09-07 | 1995-05-18 | Blutspendedienst Der Drk Lande | Verfahren zur Herstellung eines AHF-Konzentrates |
| GB2293100A (en) | 1994-09-15 | 1996-03-20 | Medeva Europ Ltd | Pharmaceutical compositions with deuterium oxide |
| SE503424C2 (sv) | 1994-11-14 | 1996-06-10 | Pharmacia Ab | Process för rening av rekombinant koagulationsfaktor VIII |
| SE9403915D0 (sv) | 1994-11-14 | 1994-11-14 | Annelie Almstedt | Process A |
| AU4526996A (en) * | 1994-12-28 | 1996-07-19 | Biotime, Inc. | Plasma expanders and blood substitutes |
| GB9501040D0 (en) * | 1995-01-19 | 1995-03-08 | Quadrant Holdings Cambridge | Dried composition |
| SE9501189D0 (sv) * | 1995-03-31 | 1995-03-31 | Pharmacia Ab | Protein formulation |
| US5679549A (en) | 1995-05-04 | 1997-10-21 | Bayer Corporation | Production of recombinant factor VIII in the presence of liposome-like substances of mixed composition |
| JP3927248B2 (ja) * | 1995-07-11 | 2007-06-06 | 第一製薬株式会社 | Hgf凍結乾燥製剤 |
| KR0167677B1 (ko) * | 1995-08-31 | 1999-02-01 | 김광호 | 다중 비트 테스트를 위한 패턴 발생기를 가지는 메모리 테스트 시스템 |
| SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
| ES2099678B1 (es) | 1995-11-03 | 1998-02-16 | Grifols Grupo Sa | Procedimiento para la inactivacion de virus en proteinas. |
| CA2236873A1 (en) | 1995-11-06 | 1997-05-15 | New York Blood Center, Inc. | Viral inactivation treatment of red blood cells using phthalocyanines and red light |
| US5659017A (en) | 1995-11-07 | 1997-08-19 | Alpha Therapeutic Corporation | Anion exchange process for the purification of Factor VIII |
| US5925738A (en) | 1995-12-01 | 1999-07-20 | The American National Red Cross | Methods of production and use of liquid formulations of plasma proteins |
| US5851800A (en) | 1996-05-14 | 1998-12-22 | Pharmacia & Upjohn Ab | Process for producing a protein |
| US6632648B1 (en) | 1996-05-14 | 2003-10-14 | Elan Drug Delivery Limited | Methods of terminal sterilization of fibrinogen |
| US5763401A (en) | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
| EP1820516B1 (en) * | 1999-02-22 | 2013-07-24 | University of Connecticut | Novel albumin-free factor VIII formulations |
| EP1194161B1 (en) | 1999-07-13 | 2005-11-23 | Biovitrum Ab | Stable factor viii compositions |
| US6440414B1 (en) * | 1999-10-01 | 2002-08-27 | Amgen Inc. | Pharmaceutical compositions of fibrinolytic agent |
| EP2311437A1 (en) | 2003-12-19 | 2011-04-20 | Novo Nordisk Health Care AG | Stabilised compositions of factor VII polypeptides |
| JP5231810B2 (ja) | 2005-12-28 | 2013-07-10 | 中外製薬株式会社 | 抗体含有安定化製剤 |
| US9283260B2 (en) | 2006-04-21 | 2016-03-15 | Amgen Inc. | Lyophilized therapeutic peptibody formulations |
| KR101691070B1 (ko) | 2008-09-03 | 2016-12-29 | 옥타파마 아게 | 재조합에 의해 제조된 인자 ⅷ을 위한 신규한 보호 조성물 |
-
2000
- 2000-02-22 EP EP06077229.0A patent/EP1820516B1/en not_active Expired - Lifetime
- 2000-02-22 BR BRPI0008405-0B1A patent/BR0008405B1/pt not_active IP Right Cessation
- 2000-02-22 CA CA2362927A patent/CA2362927C/en not_active Expired - Lifetime
- 2000-02-22 US US09/507,011 patent/US6586573B1/en not_active Expired - Lifetime
- 2000-02-22 PL PL356453A patent/PL198123B1/pl unknown
- 2000-02-22 EP EP09075396A patent/EP2130554B1/en not_active Revoked
- 2000-02-22 ES ES10075019.9T patent/ES2541470T3/es not_active Expired - Lifetime
- 2000-02-22 AT AT00907322T patent/ATE365052T1/de active
- 2000-02-22 CA CA002634674A patent/CA2634674A1/en not_active Abandoned
- 2000-02-22 PL PL382299A patent/PL203893B1/pl unknown
- 2000-02-22 CN CNB008063044A patent/CN100553678C/zh not_active Expired - Lifetime
- 2000-02-22 EP EP15154020.0A patent/EP2921180B1/en not_active Expired - Lifetime
- 2000-02-22 ES ES00907322T patent/ES2288843T3/es not_active Expired - Lifetime
- 2000-02-22 PT PT09075396T patent/PT2130554E/pt unknown
- 2000-02-22 PL PL382288A patent/PL203177B1/pl unknown
- 2000-02-22 PL PL382300A patent/PL204701B1/pl unknown
- 2000-02-22 PT PT60772290T patent/PT1820516E/pt unknown
- 2000-02-22 JP JP2000599425A patent/JP5149470B2/ja not_active Expired - Lifetime
- 2000-02-22 CZ CZ2008-828A patent/CZ307715B6/cs not_active IP Right Cessation
- 2000-02-22 CZ CZ20012996A patent/CZ300547B6/cs not_active IP Right Cessation
- 2000-02-22 PT PT100750199T patent/PT2193809E/pt unknown
- 2000-02-22 CA CA2634664A patent/CA2634664C/en not_active Expired - Lifetime
- 2000-02-22 WO PCT/US2000/040068 patent/WO2000048635A1/en not_active Ceased
- 2000-02-22 DE DE60035260T patent/DE60035260T2/de not_active Expired - Lifetime
- 2000-02-22 DK DK00907322T patent/DK1154796T3/da active
- 2000-02-22 DK DK06077229.0T patent/DK1820516T3/da active
- 2000-02-22 EP EP10075019.9A patent/EP2193809B1/en not_active Expired - Lifetime
- 2000-02-22 CZ CZ2008-827A patent/CZ307322B6/cs not_active IP Right Cessation
- 2000-02-22 ES ES06077229T patent/ES2435141T3/es not_active Expired - Lifetime
- 2000-02-22 CN CN200910171121A patent/CN101810854A/zh active Pending
- 2000-02-22 PT PT00907322T patent/PT1154796E/pt unknown
- 2000-02-22 MX MXPA01008515A patent/MXPA01008515A/es active IP Right Grant
- 2000-02-22 CN CN2009101711245A patent/CN101683522B/zh not_active Expired - Lifetime
- 2000-02-22 ES ES09075396T patent/ES2394755T3/es not_active Expired - Lifetime
- 2000-02-22 DK DK10075019.9T patent/DK2193809T3/en active
- 2000-02-22 RU RU2001125929/15A patent/RU2244556C2/ru active
- 2000-02-22 AU AU28843/00A patent/AU777972B2/en not_active Expired
- 2000-02-22 CA CA002634663A patent/CA2634663C/en not_active Expired - Lifetime
- 2000-02-22 DK DK09075396.3T patent/DK2130554T3/da active
- 2000-02-22 EP EP00907322A patent/EP1154796B1/en not_active Expired - Lifetime
-
2003
- 2003-07-01 US US10/610,723 patent/US7087723B2/en not_active Expired - Lifetime
-
2006
- 2006-05-15 US US11/434,634 patent/US7247707B2/en not_active Expired - Lifetime
-
2007
- 2007-06-18 US US11/764,770 patent/US8058226B2/en not_active Expired - Lifetime
- 2007-08-07 CY CY20071101050T patent/CY1108030T1/el unknown
-
2008
- 2008-05-01 JP JP2008120035A patent/JP5006832B2/ja not_active Expired - Lifetime
- 2008-09-30 JP JP2008255510A patent/JP5140539B2/ja not_active Expired - Lifetime
-
2011
- 2011-09-30 US US13/250,789 patent/US8372800B2/en not_active Expired - Fee Related
-
2012
- 2012-01-20 JP JP2012009767A patent/JP5596064B2/ja not_active Expired - Lifetime
- 2012-12-04 CY CY20121101185T patent/CY1113969T1/el unknown
-
2013
- 2013-02-06 US US13/760,900 patent/US8765665B2/en not_active Expired - Fee Related
- 2013-11-01 JP JP2013227977A patent/JP6038003B2/ja not_active Expired - Lifetime
-
2014
- 2014-05-23 US US14/286,391 patent/US9352027B2/en not_active Expired - Fee Related
-
2015
- 2015-02-20 JP JP2015031316A patent/JP6155442B2/ja not_active Expired - Lifetime
- 2015-11-11 JP JP2015220875A patent/JP6253627B2/ja not_active Expired - Lifetime
-
2016
- 2016-02-18 HK HK16101857.2A patent/HK1213801A1/en unknown
- 2016-05-04 US US15/146,835 patent/US9669076B2/en not_active Expired - Fee Related
-
2017
- 2017-04-27 JP JP2017088289A patent/JP2017125076A/ja not_active Withdrawn
-
2018
- 2018-07-02 JP JP2018125917A patent/JP2018172413A/ja active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016520075A5 (enExample) | ||
| JP4902103B2 (ja) | 凍結乾燥フォームによる生物活性材料の保存 | |
| CN1152713C (zh) | 含有海藻糖的干燥的血液因子组合物 | |
| JP2015231997A5 (enExample) | ||
| JP2017531682A5 (enExample) | ||
| JP2021521159A5 (enExample) | ||
| JP2009540001A5 (enExample) | ||
| JP2014139229A5 (enExample) | ||
| JP2013079270A5 (enExample) | ||
| PE20241346A1 (es) | Vectores del factor viii del virus adeno-asociado, particulas viricas asociadas y formulaciones que los comprenden | |
| RU2016150640A (ru) | Жидкая фармацевтическая композиция | |
| JP2014040441A5 (enExample) | ||
| JP2013511522A (ja) | ダプトマイシン製剤 | |
| US20170189528A1 (en) | Stable aqueous adalimumab formulation | |
| FI3725330T3 (fi) | Polypeptidien stabiilit valmisteet ja niiden käyttötarkoitukset | |
| RU2011151286A (ru) | Лиофилизированные рецептуры для малых модульных иммунофармацевтических средств | |
| MX2016012447A (es) | Formulaciones de factor ix liofilizadas. | |
| JP2013543505A5 (enExample) | ||
| RU2011112787A (ru) | Новые защитные композиции для рекомбинантного фактора viii | |
| JP2017510585A5 (enExample) | ||
| JP2012136518A5 (enExample) | ||
| JP2017514868A5 (enExample) | ||
| US20070190047A1 (en) | Formulations that inhibit protein aggregation | |
| JP2013544288A5 (enExample) | ||
| JP2018532806A5 (enExample) |