JP2017510585A5 - - Google Patents
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- JP2017510585A5 JP2017510585A5 JP2016558751A JP2016558751A JP2017510585A5 JP 2017510585 A5 JP2017510585 A5 JP 2017510585A5 JP 2016558751 A JP2016558751 A JP 2016558751A JP 2016558751 A JP2016558751 A JP 2016558751A JP 2017510585 A5 JP2017510585 A5 JP 2017510585A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- item
- lyophilized
- less
- temperature
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022007013A JP7503583B2 (ja) | 2014-03-24 | 2022-01-20 | 凍結乾燥第ｉｘ因子製剤 |
| JP2024033771A JP7759978B2 (ja) | 2014-03-24 | 2024-03-06 | 凍結乾燥第ｉｘ因子製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461969801P | 2014-03-24 | 2014-03-24 | |
| US61/969,801 | 2014-03-24 | ||
| PCT/US2015/022141 WO2015148444A1 (en) | 2014-03-24 | 2015-03-24 | Lyophilized factor ix formulations |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020016131A Division JP2020063313A (ja) | 2014-03-24 | 2020-02-03 | 凍結乾燥第ｉｘ因子製剤 |
| JP2022007013A Division JP7503583B2 (ja) | 2014-03-24 | 2022-01-20 | 凍結乾燥第ｉｘ因子製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017510585A JP2017510585A (ja) | 2017-04-13 |
| JP2017510585A5 true JP2017510585A5 (enExample) | 2018-05-10 |
| JP7058940B2 JP7058940B2 (ja) | 2022-04-25 |
Family
ID=54196282
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016558751A Active JP7058940B2 (ja) | 2014-03-24 | 2015-03-24 | 凍結乾燥第ｉｘ因子製剤 |
| JP2020016131A Pending JP2020063313A (ja) | 2014-03-24 | 2020-02-03 | 凍結乾燥第ｉｘ因子製剤 |
| JP2022007013A Active JP7503583B2 (ja) | 2014-03-24 | 2022-01-20 | 凍結乾燥第ｉｘ因子製剤 |
| JP2024033771A Active JP7759978B2 (ja) | 2014-03-24 | 2024-03-06 | 凍結乾燥第ｉｘ因子製剤 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020016131A Pending JP2020063313A (ja) | 2014-03-24 | 2020-02-03 | 凍結乾燥第ｉｘ因子製剤 |
| JP2022007013A Active JP7503583B2 (ja) | 2014-03-24 | 2022-01-20 | 凍結乾燥第ｉｘ因子製剤 |
| JP2024033771A Active JP7759978B2 (ja) | 2014-03-24 | 2024-03-06 | 凍結乾燥第ｉｘ因子製剤 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US10772942B2 (enExample) |
| EP (1) | EP3123090A4 (enExample) |
| JP (4) | JP7058940B2 (enExample) |
| KR (1) | KR102385372B1 (enExample) |
| AR (1) | AR099838A1 (enExample) |
| AU (2) | AU2015236340B2 (enExample) |
| CA (1) | CA2943034C (enExample) |
| CL (1) | CL2016002386A1 (enExample) |
| EA (2) | EA202092926A3 (enExample) |
| IL (3) | IL247869B (enExample) |
| MA (1) | MA39779A (enExample) |
| MX (2) | MX387269B (enExample) |
| PH (1) | PH12016501877A1 (enExample) |
| SG (3) | SG10201913735SA (enExample) |
| TW (1) | TWI700101B (enExample) |
| WO (1) | WO2015148444A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI788044B (zh) * | 2013-03-15 | 2022-12-21 | 美商百歐維拉提夫治療公司 | 因子ｉｘ多肽調配物 |
| SG10201913735SA (en) | 2014-03-24 | 2020-03-30 | Bioverativ Therapeutics Inc | Lyophilized factor ix formulations |
| BR112019011115A2 (pt) * | 2016-12-02 | 2019-10-01 | Bioverativ Therapeutics Inc. | métodos para tratar artropatia hemofílica usando fatores de coagulação quiméricos |
| MX2020000480A (es) * | 2017-07-11 | 2020-09-10 | Universal Stabilization Tech Inc | Método para la conservación de material biológico. |
| CN112175088B (zh) * | 2019-07-02 | 2023-03-28 | 江苏晟斯生物制药有限公司 | 改进的fix融合蛋白、缀合物及其应用 |
| MX2022009558A (es) | 2020-02-04 | 2022-09-09 | Regeneron Pharma | Contenido de humedad residual objetivo para farmaco liofilizado. |
| JP2023526024A (ja) * | 2020-05-11 | 2023-06-20 | アルカームス ファーマ アイルランド リミテッド | Ｉｌ－２融合ポリペプチド組成物ならびにその作製及び使用方法 |
| CN118557531B (zh) * | 2024-08-02 | 2024-10-18 | 成都蓉生药业有限责任公司 | 一种重组人凝血因子VIII-Fc融合蛋白冻干制剂的制备方法 |
Family Cites Families (58)
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| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| WO1990006952A1 (fr) | 1988-12-22 | 1990-06-28 | Kirin-Amgen, Inc. | Facteur de stimulation de colonies de granulocytes modifies chimiquement |
| WO1990009800A1 (en) | 1989-02-21 | 1990-09-07 | Washington University | Modified forms of reproductive hormones |
| US6552170B1 (en) | 1990-04-06 | 2003-04-22 | Amgen Inc. | PEGylation reagents and compounds formed therewith |
| DK0575545T3 (da) | 1991-03-15 | 2003-09-15 | Amgen Inc | Pegylering af polypeptider |
| FR2686899B1 (fr) | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
| WO1994007510A1 (en) | 1992-10-02 | 1994-04-14 | Kabi Pharmacia Ab | Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer |
| DE4405426A1 (de) | 1994-02-21 | 1995-08-24 | Boehringer Mannheim Gmbh | Pharmazeutisches Präparat enthaltend Plasminogenaktivator (t-PA) oder dessen Derivate |
| US6372716B1 (en) | 1994-04-26 | 2002-04-16 | Genetics Institute, Inc. | Formulations for factor IX |
| US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| US5770700A (en) * | 1996-01-25 | 1998-06-23 | Genetics Institute, Inc. | Liquid factor IX formulations |
| IN184589B (enExample) | 1996-10-16 | 2000-09-09 | Alza Corp | |
| US20010031721A1 (en) | 1999-05-05 | 2001-10-18 | Chandra Webb | Highly concentrated, lyophilized, and liquid factor IX formulations |
| JP2001151694A (ja) | 1999-09-17 | 2001-06-05 | Takeda Chem Ind Ltd | タンパク質粉体の製造法 |
| KR20020063853A (ko) * | 1999-09-17 | 2002-08-05 | 다케다 야쿠힌 고교 가부시키가이샤 | 단백질 분체의 제조 방법 |
| AU4314801A (en) | 2000-02-11 | 2001-08-20 | Lexigen Pharm Corp | Enhancing the circulating half-life of antibody-based fusion proteins |
| WO2002040544A2 (en) | 2000-11-14 | 2002-05-23 | Board Of Regents, University Of Texas Systems | Mutant human factor ix with an increased resistance to inhibition by heparin |
| EP1427820A2 (en) | 2001-09-04 | 2004-06-16 | MERCK PATENT GmbH | Modified factor ix |
| WO2003060071A2 (en) | 2001-12-21 | 2003-07-24 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP3552627A1 (en) | 2003-05-06 | 2019-10-16 | Bioverativ Therapeutics Inc. | Clotting factor-fc chimeric proteins to treat hemophilia |
| US7348004B2 (en) | 2003-05-06 | 2008-03-25 | Syntonix Pharmaceuticals, Inc. | Immunoglobulin chimeric monomer-dimer hybrids |
| TWI353991B (en) * | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
| JP2005060378A (ja) | 2003-07-28 | 2005-03-10 | Yamanouchi Pharmaceut Co Ltd | 生理活性蛋白質含有凍結乾燥製剤 |
| US20050152979A1 (en) | 2003-09-05 | 2005-07-14 | Cell Therapeutics, Inc. | Hydrophobic drug compositions containing reconstitution enhancer |
| EP2311437A1 (en) | 2003-12-19 | 2011-04-20 | Novo Nordisk Health Care AG | Stabilised compositions of factor VII polypeptides |
| CA2554018A1 (en) | 2004-03-04 | 2005-09-29 | Wyeth | Lyophilization method to improve excipient crystallization |
| WO2006029467A1 (en) | 2004-09-16 | 2006-03-23 | Btf Pty Ltd | Rapid freeze drying process |
| US8367805B2 (en) | 2004-11-12 | 2013-02-05 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| LT2371856T (lt) | 2004-11-12 | 2022-08-25 | Bayer Healthcare Llc | Fviii modifikacija, nukreipta į tam tikrą vietą |
| KR101283736B1 (ko) | 2004-12-15 | 2013-07-08 | 스위디쉬 오르펀 바이오비트럼 에이비(피유비엘) | 케라티노사이트 성장 인자의 치료학적 제형 |
| EP2377554A1 (en) * | 2005-07-22 | 2011-10-19 | Amgen, Inc | Concentrated protein lyophilates, methods and uses |
| EP1951757B1 (en) * | 2005-10-06 | 2014-05-14 | Xencor, Inc. | Optimized anti-cd30 antibodies |
| BRPI0618133A2 (pt) | 2005-11-01 | 2011-08-16 | Wyeth Corp | solução de cloreto de sódio para reconstituição ou diluição de droga |
| US8048848B2 (en) | 2006-02-03 | 2011-11-01 | Prolor Biotech Ltd. | Long-acting interferons and derivatives thereof and methods thereof |
| EP2004683B1 (en) | 2006-03-24 | 2016-05-11 | Biogen Hemophilia Inc. | Pc5 as a factor ix propeptide processing enzyme |
| KR101504969B1 (ko) | 2006-04-04 | 2015-03-24 | 샤이어 파마슈티칼스 아일랜드 리미티드 | 폴리펩타이드의 농축 방법 |
| TW200804416A (en) | 2006-06-19 | 2008-01-16 | Nautilus Technology Llc | Modified coagulation factor IX polypeptides and use thereof for treatment |
| US8015841B2 (en) | 2006-09-08 | 2011-09-13 | Praxair Technology, Inc. | Cryogenic refrigeration system for lyophilization |
| US7700734B2 (en) | 2007-01-09 | 2010-04-20 | Shu-Wha Lin | Recombinant human factor IX and use thereof |
| KR101631323B1 (ko) | 2007-06-21 | 2016-06-17 | 엑스엘-프로테인 게엠베하 | 증가된 생체내 및/또는 시험관내 안정성을 갖는 생물학적 활성 단백질 |
| CN102026653B (zh) | 2007-10-15 | 2014-06-18 | 北卡罗来纳-查佩尔山大学 | 半衰期延长的人因子ⅸ变体 |
| CN101903030A (zh) | 2007-12-21 | 2010-12-01 | 灵感生物制药学有限公司 | 含海藻糖的稳定化因子ix制剂 |
| NZ585835A (en) | 2007-12-27 | 2012-07-27 | Baxter Int | Chemically modified factor IX comprising a hydrophilic polymer attached via a releasable linker |
| JP2011517950A (ja) | 2008-04-16 | 2011-06-23 | バイエル・ヘルスケア・エルエルシー | 第ｉｘ因子の部位特異的修飾 |
| WO2009137254A2 (en) | 2008-04-16 | 2009-11-12 | Bayer Healthcare Llc | Modified factor ix polypeptides and uses thereof |
| WO2009130198A2 (en) | 2008-04-21 | 2009-10-29 | Novo Nordisk A/S | Hyperglycosylated human coagulation factor ix |
| AU2009239641B2 (en) | 2008-04-24 | 2013-11-07 | Cantab Biopharmaceuticals Patents Limited | Factor IX conjugates with extended half-lives |
| ES2755029T3 (es) | 2008-08-05 | 2020-04-21 | Wyeth Llc | Liofilización por encima de la temperatura de colapso |
| CN102164943A (zh) | 2008-09-24 | 2011-08-24 | 稳定技术有限公司 | 使用糖和聚乙烯亚胺保存多肽的方法 |
| US20120114646A1 (en) | 2009-06-18 | 2012-05-10 | Wyeth Llc | Lyophilized formulations for small modular immunopharmaceuticals |
| EP2458990B1 (en) * | 2009-07-28 | 2016-03-30 | Merck Sharp & Dohme Corp. | Methods for producing high concentration lyophilized pharmaceutical formulations |
| EA028067B1 (ru) | 2010-07-09 | 2017-10-31 | Байоджен Хемофилия Инк. | Способы контроля или предотвращения кровотечения или эпизодов кровотечения |
| US20130217708A1 (en) | 2010-09-30 | 2013-08-22 | Toyama Chemical Co., Ltd. | Meglumine salt of 6-fluoro-3-hydroxy-2-pyrazine carboxamide |
| US10286037B2 (en) | 2011-02-09 | 2019-05-14 | Glaxosmithkline Llc | Methods of producing lyophilized polypeptide composition formulations comprising volatile additives |
| WO2013185113A1 (en) | 2012-06-08 | 2013-12-12 | Biogen Idec Ma Inc. | Procoagulant compounds |
| WO2014052490A1 (en) * | 2012-09-25 | 2014-04-03 | Biogen Idec Ma Inc. | Methods of using fix polypeptides |
| TWI788044B (zh) | 2013-03-15 | 2022-12-21 | 美商百歐維拉提夫治療公司 | 因子ｉｘ多肽調配物 |
| SG10201913735SA (en) * | 2014-03-24 | 2020-03-30 | Bioverativ Therapeutics Inc | Lyophilized factor ix formulations |
-
2015
- 2015-03-24 SG SG10201913735SA patent/SG10201913735SA/en unknown
- 2015-03-24 MA MA039779A patent/MA39779A/fr unknown
- 2015-03-24 CA CA2943034A patent/CA2943034C/en active Active
- 2015-03-24 WO PCT/US2015/022141 patent/WO2015148444A1/en not_active Ceased
- 2015-03-24 KR KR1020167028692A patent/KR102385372B1/ko active Active
- 2015-03-24 AU AU2015236340A patent/AU2015236340B2/en not_active Withdrawn - After Issue
- 2015-03-24 EA EA202092926A patent/EA202092926A3/ru unknown
- 2015-03-24 SG SG10201808249VA patent/SG10201808249VA/en unknown
- 2015-03-24 SG SG11201607642RA patent/SG11201607642RA/en unknown
- 2015-03-24 TW TW104109389A patent/TWI700101B/zh active
- 2015-03-24 JP JP2016558751A patent/JP7058940B2/ja active Active
- 2015-03-24 US US15/128,951 patent/US10772942B2/en active Active
- 2015-03-24 EP EP15769411.8A patent/EP3123090A4/en active Pending
- 2015-03-24 EA EA201691807A patent/EA038573B1/ru unknown
- 2015-03-24 MX MX2016012447A patent/MX387269B/es unknown
- 2015-03-25 AR ARP150100880A patent/AR099838A1/es unknown
-
2016
- 2016-09-18 IL IL247869A patent/IL247869B/en active IP Right Grant
- 2016-09-22 CL CL2016002386A patent/CL2016002386A1/es unknown
- 2016-09-23 MX MX2021012939A patent/MX2021012939A/es unknown
- 2016-09-23 PH PH12016501877A patent/PH12016501877A1/en unknown
-
2020
- 2020-01-26 IL IL272257A patent/IL272257B/en active IP Right Grant
- 2020-02-03 JP JP2020016131A patent/JP2020063313A/ja active Pending
- 2020-04-30 AU AU2020202863A patent/AU2020202863B2/en active Active
- 2020-08-17 US US16/995,173 patent/US12128092B2/en active Active
-
2021
- 2021-03-02 IL IL281197A patent/IL281197B/en unknown
-
2022
- 2022-01-20 JP JP2022007013A patent/JP7503583B2/ja active Active
-
2024
- 2024-03-06 JP JP2024033771A patent/JP7759978B2/ja active Active
- 2024-09-24 US US18/894,851 patent/US20250121042A1/en active Pending
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