JP2009540001A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009540001A5 JP2009540001A5 JP2009515517A JP2009515517A JP2009540001A5 JP 2009540001 A5 JP2009540001 A5 JP 2009540001A5 JP 2009515517 A JP2009515517 A JP 2009515517A JP 2009515517 A JP2009515517 A JP 2009515517A JP 2009540001 A5 JP2009540001 A5 JP 2009540001A5
- Authority
- JP
- Japan
- Prior art keywords
- polysorbate
- formulation
- vegf antagonist
- sodium phosphate
- phosphate buffer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81448406P | 2006-06-16 | 2006-06-16 | |
| US60/814,484 | 2006-06-16 | ||
| PCT/US2007/014085 WO2007149334A2 (en) | 2006-06-16 | 2007-06-14 | Vegf antagonist formulations suitable for intravitreal administration |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013040234A Division JP5597271B2 (ja) | 2006-06-16 | 2013-03-01 | 硝子体内投与に適したｖｅｇｆアンタゴニスト製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009540001A JP2009540001A (ja) | 2009-11-19 |
| JP2009540001A5 true JP2009540001A5 (enExample) | 2013-02-07 |
| JP5216002B2 JP5216002B2 (ja) | 2013-06-19 |
Family
ID=38834013
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009515517A Active JP5216002B2 (ja) | 2006-06-16 | 2007-06-14 | 硝子体内投与に適したｖｅｇｆアンタゴニスト製剤 |
| JP2013040234A Active JP5597271B2 (ja) | 2006-06-16 | 2013-03-01 | 硝子体内投与に適したｖｅｇｆアンタゴニスト製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013040234A Active JP5597271B2 (ja) | 2006-06-16 | 2013-03-01 | 硝子体内投与に適したｖｅｇｆアンタゴニスト製剤 |
Country Status (22)
| Country | Link |
|---|---|
| US (16) | US7608261B2 (enExample) |
| EP (4) | EP2029103A2 (enExample) |
| JP (2) | JP5216002B2 (enExample) |
| KR (1) | KR101406811B1 (enExample) |
| CN (2) | CN101478949A (enExample) |
| AU (1) | AU2007261536C1 (enExample) |
| BR (1) | BRPI0713749B8 (enExample) |
| CA (1) | CA2654510C (enExample) |
| CY (2) | CY1114244T1 (enExample) |
| DK (2) | DK2944306T3 (enExample) |
| ES (2) | ES2861898T3 (enExample) |
| HK (1) | HK1204580A1 (enExample) |
| HU (2) | HUE053612T2 (enExample) |
| IL (1) | IL195788A (enExample) |
| LT (1) | LT2944306T (enExample) |
| MX (1) | MX2008016124A (enExample) |
| PL (2) | PL2364691T3 (enExample) |
| PT (2) | PT2944306T (enExample) |
| RU (1) | RU2432155C3 (enExample) |
| SI (2) | SI2944306T1 (enExample) |
| WO (1) | WO2007149334A2 (enExample) |
| ZA (1) | ZA200809827B (enExample) |
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ592039A (en) * | 2003-08-27 | 2013-03-28 | Ophthotech Corp | Combination therapy for the treatment of ocular neovascular disorders |
| CA3142945A1 (en) | 2005-03-25 | 2006-10-05 | Regeneron Pharmaceuticals, Inc. | Histidine-buffered formulations of vegf antagonist |
| ES2828739T3 (es) | 2006-04-07 | 2021-05-27 | Aerpio Pharmaceuticals Inc | Anticuerpos que se unen a la proteína tirosina fosfatasa beta humana (HPTP-beta) y sus usos |
| CA2654510C (en) | 2006-06-16 | 2015-03-17 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
| DE602008006064D1 (de) | 2007-01-18 | 2011-05-19 | Eveready Battery Inc | Rasiersystem mit gaserzeugungszelle |
| US20130064834A1 (en) | 2008-12-15 | 2013-03-14 | Regeneron Pharmaceuticals, Inc. | Methods for treating hypercholesterolemia using antibodies to pcsk9 |
| JO3672B1 (ar) | 2008-12-15 | 2020-08-27 | Regeneron Pharma | أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9). |
| US8956600B2 (en) * | 2009-08-10 | 2015-02-17 | Taiwan Liposome Co. Ltd. | Ophthalmic drug delivery system containing phospholipid and cholesterol |
| MX366337B (es) | 2010-10-06 | 2019-07-05 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-receptor de interleucina-4 (il-4r). |
| KR20180023015A (ko) | 2011-01-13 | 2018-03-06 | 리제너론 파아마슈티컬스, 인크. | 혈관신생 눈 장애를 치료하기 위한 vegf 길항제의 용도 |
| CA2825778A1 (en) | 2011-01-28 | 2012-08-02 | Sanofi | Pharmaceutical compositions comprising human antibodies to pcsk9 |
| JO3283B1 (ar) | 2011-04-26 | 2018-09-16 | Sanofi Sa | تركيب يتضمن أفليبيرسيبت, حمض فولينيك, 5- فلورويوراسيل (5- Fu) وإرينوسيتان (FOLFIRI) |
| AR087305A1 (es) | 2011-07-28 | 2014-03-12 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-pcsk9, metodo de preparacion y kit |
| ES2773111T3 (es) | 2011-09-16 | 2020-07-09 | Regeneron Pharma | Inhibidor de la proproteína convertasa subtilisina/kexina 9 (PCSK9) para su uso en la reducción de los niveles de lipoproteína (a) |
| MX363351B (es) | 2011-10-13 | 2019-03-20 | Aerpio Therapeutics Inc | Un agente de unión a hptp?-ecd para usarse en el tratamiento de síndrome de fuga vascular. |
| AU2012340107B2 (en) | 2011-11-18 | 2017-06-15 | Regeneron Pharmaceuticals, Inc. | Polymer protein microparticles |
| CN107115294B (zh) * | 2012-01-19 | 2019-10-18 | 北京康弘生物医药有限公司 | 一种含有vegf拮抗剂的滴眼液 |
| KR102063028B1 (ko) | 2012-01-23 | 2020-01-07 | 리제너론 파아마슈티컬스, 인크. | 항-ａｎｇ2 항체를 함유하는 안정화된 제형 |
| AR092325A1 (es) | 2012-05-31 | 2015-04-15 | Regeneron Pharma | Formulaciones estabilizadas que contienen anticuerpos anti-dll4 y kit |
| JP2015519373A (ja) * | 2012-06-01 | 2015-07-09 | オプソテック コーポレイションＯｐｈｔｈｏｔｅｃｈ Ｃｏｒｐｏｒａｔｉｏｎ | 抗ｐｄｇｆアプタマーおよびｖｅｇｆ拮抗薬を含む組成物 |
| US20130323242A1 (en) * | 2012-06-01 | 2013-12-05 | Ophthotech Corp. | Compositions comprising an anti-pdgf aptamer and a vegf antagonist |
| HUE055994T2 (hu) * | 2012-06-01 | 2022-01-28 | Novartis Ag | Fecskendõ |
| AU2013100360B4 (en) * | 2012-07-03 | 2013-05-16 | Novartis Ag | Device |
| DE202013000688U1 (de) * | 2012-07-03 | 2013-03-05 | Novartis Ag | Glas-Spritze |
| AU2013100070B4 (en) * | 2012-07-03 | 2013-04-04 | Novartis Ag | Use of device |
| AU2012101678B4 (en) * | 2012-07-03 | 2013-01-24 | Novartis Ag | Use of device |
| CN102819150A (zh) | 2012-08-06 | 2012-12-12 | 深圳市华星光电技术有限公司 | 液晶注入装置及液晶容器 |
| UA115789C2 (uk) | 2012-09-05 | 2017-12-26 | Трейкон Фармасутікалз, Інк. | Композиція антитіла до cd105 та її застосування |
| MY170528A (en) | 2013-02-18 | 2019-08-09 | Vegenics Pty Ltd | Vegfr-3 ligand binding molecules and uses thereof |
| US10111953B2 (en) | 2013-05-30 | 2018-10-30 | Regeneron Pharmaceuticals, Inc. | Methods for reducing remnant cholesterol and other lipoprotein fractions by administering an inhibitor of proprotein convertase subtilisin kexin-9 (PCSK9) |
| TW201534324A (zh) | 2013-06-07 | 2015-09-16 | Sanofi Sa | 藉由投與ｐｃｓｋ９抑制劑抑制動脈粥狀硬化的方法 |
| SI4374873T1 (sl) | 2013-07-12 | 2026-01-30 | Astellas Us Llc | Sredstvo za uporabo pri zdravljenju ali preprečevanju oftalmoloških stanj |
| DK3024484T3 (en) | 2013-07-23 | 2018-10-08 | Novaliq Gmbh | STABILIZED ANTIBODY COMPOSITIONS |
| MX2016001854A (es) | 2013-08-12 | 2016-09-06 | Genentech Inc | Composiciones y metodo para tratar condiciones asociadas con el complemento. |
| CN103622961B (zh) * | 2013-09-06 | 2016-03-02 | 武汉光谷百桥国际生物科技有限公司 | 一种非肽类缓激肽b2受体激动剂在促进毛发生长方面的应用 |
| US10428157B2 (en) | 2013-11-12 | 2019-10-01 | Sanofi Biotechnology | Dosing regimens for use with PCSK9 inhibitors |
| ES2875878T3 (es) * | 2013-11-18 | 2021-11-11 | Formycon Ag | Composición farmacéutica de un anticuerpo anti-VEGF |
| SG11201608868PA (en) | 2014-05-01 | 2016-11-29 | Genentech Inc | Anti-factor d antibody variants and uses thereof |
| WO2015200905A2 (en) | 2014-06-28 | 2015-12-30 | Oligasis, Llc | Dual pdgf/vegf antagonists |
| KR20230074283A (ko) | 2014-07-16 | 2023-05-26 | 사노피 바이오테크놀로지 | 이형접합성 가족성 고콜레스테롤혈증(heFH) 환자의 치료방법 |
| RS58957B1 (sr) | 2014-07-18 | 2019-08-30 | Sanofi Sa | Postupak za predviđanje ishoda tretmana sa afliberceptom kod pacijenta za kog se sumnja da boluje od raka |
| CN104940926B (zh) * | 2014-09-25 | 2017-09-22 | 信达生物制药(苏州)有限公司 | 重组融合蛋白制剂 |
| AR102198A1 (es) | 2014-10-09 | 2017-02-08 | Regeneron Pharma | Proceso para reducir partículas subvisibles en una formulación farmacéutica |
| TWI806150B (zh) | 2014-11-07 | 2023-06-21 | 瑞士商諾華公司 | 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 |
| US20160144025A1 (en) * | 2014-11-25 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and formulations for treating vascular eye diseases |
| WO2016120753A1 (en) | 2015-01-28 | 2016-08-04 | Pfizer Inc. | Stable aqueous anti- vascular endothelial growth factor (vegf) antibody formulation |
| KR101808234B1 (ko) | 2015-06-23 | 2017-12-12 | (주)알테오젠 | IgG Fc 도메인을 가지는 융합 단백질의 안정한 액상 제제 |
| EA201890519A1 (ru) | 2015-08-18 | 2018-07-31 | Ридженерон Фармасьютикалз, Инк. | Ингибирующие антитела против pcsk9 для лечения пациентов с гиперлипидемией, подвергающихся аферезу липопротеинов |
| US20170087100A1 (en) | 2015-09-30 | 2017-03-30 | Novaliq Gmbh | Semifluorinated compounds and their compositions |
| KR20180090785A (ko) | 2015-10-07 | 2018-08-13 | 아펠리스 파마슈티컬스 인코포레이티드 | 투여 요법 |
| MX390837B (es) * | 2015-10-16 | 2025-03-21 | Regeneron Pharma | Composiciones de proteinas estables. |
| TW201730211A (zh) | 2015-10-30 | 2017-09-01 | 建南德克公司 | 抗因子d抗體及結合物 |
| JP2018536650A (ja) | 2015-10-30 | 2018-12-13 | ジェネンテック， インコーポレイテッド | 抗ｄ因子抗体変異体コンジュゲート及びその使用 |
| CN108883172A (zh) | 2015-11-18 | 2018-11-23 | 福迈康股份公司 | 包含vegf拮抗剂的液体配制品的预填充药物包装 |
| KR102854749B1 (ko) | 2015-11-18 | 2025-09-04 | 에스아이오2 메디컬 프로덕츠, 엘엘씨 | 안과 제제용 제약 패키지 |
| KR20210157427A (ko) | 2015-12-03 | 2021-12-28 | 리제너론 파마슈티칼스 인코포레이티드 | 항-vegf로 치료된 연령-관련 황반 변성을 앓고 있는 환자에서의 임상 결과와 유전적 변이체를 연관시키는 방법 |
| MY200764A (en) * | 2015-12-16 | 2024-01-14 | Regeneron Pharma | Compositions and methods of manufacturing protein microparticles |
| IL290457B2 (en) | 2015-12-30 | 2025-02-01 | Kodiak Sciences Inc | Antibodies and their conjugates |
| EP3407868A1 (en) | 2016-01-26 | 2018-12-05 | Formycon AG | Liquid formulation of a vegf antagonist |
| GB201612317D0 (en) * | 2016-07-15 | 2016-08-31 | Philogen Spa | Antibody compositions |
| IL322404B1 (en) | 2016-07-29 | 2026-05-01 | Regeneron Pharma | Assembly line with built-in electronic visual inspection |
| AU2017312785B2 (en) | 2016-08-16 | 2024-10-10 | Regeneron Pharmaceuticals, Inc. | Methods for quantitating individual antibodies from a mixture |
| WO2018063963A1 (en) * | 2016-09-28 | 2018-04-05 | Board Of Regents, The University Of Texas System | Antibody and protein therapeutic formulations and uses thereof |
| KR102759512B1 (ko) | 2016-10-25 | 2025-02-03 | 리제너론 파아마슈티컬스, 인크. | 크로마토그래피 데이터 분석을 위한 방법 및 시스템 |
| CN109937034B (zh) * | 2016-11-21 | 2022-09-16 | 济世-伊沃泰克生物制品有限公司 | 阿柏西普制剂及其用途 |
| US20180207293A1 (en) * | 2017-01-25 | 2018-07-26 | 2C Tech Corp. | Nanoparticles for sustained ophthalmic drug delivery and methods of use |
| KR101861163B1 (ko) | 2017-04-26 | 2018-05-25 | 삼천당제약주식회사 | 안과용 약학 조성물 |
| MX389729B (es) | 2017-05-06 | 2025-03-20 | Regeneron Pharma | Uso de antagonistas de aplnr e inhibidores de vegf para tratar trastornos oculares. |
| WO2019020777A1 (en) | 2017-07-26 | 2019-01-31 | Formycon Ag | LIQUID FORMULATION OF A VEGF ANTAGONIST |
| US20200255496A1 (en) | 2017-09-18 | 2020-08-13 | Amgen Inc. | Vegfr-fc fusion protein formulations |
| WO2019060062A1 (en) | 2017-09-19 | 2019-03-28 | Regeneron Pharmaceuticals Inc. | METHODS OF REDUCING PARTICLE FORMATION AND COMPOSITIONS FORMED THEREFROM |
| CN111182893A (zh) | 2017-10-04 | 2020-05-19 | 诺瓦利克有限责任公司 | 包含f6h8的眼用组合物 |
| WO2019099921A2 (en) | 2017-11-17 | 2019-05-23 | Amgen Inc. | Vegfr-fc fusion protein formulations |
| MY202872A (en) | 2017-11-20 | 2024-05-28 | Just Evotec Biologics Inc | Aflibercept formulations containing a lysine salt as tonicifying agent and uses thereof |
| KR20200093621A (ko) | 2017-11-30 | 2020-08-05 | 리제너론 파아마슈티컬스, 인크. | 혈관형성 눈 장애를 치료하기 위한 vegf 길항제의 용도 |
| CN117405806A (zh) * | 2017-12-13 | 2024-01-16 | 里珍纳龙药品有限公司 | 管理层析柱床支架的装置和系统及相关方法 |
| JP2021507884A (ja) | 2017-12-15 | 2021-02-25 | アペリス・ファーマシューティカルズ・インコーポレイテッドＡｐｅｌｌｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． | 投与レジメンならびに関連組成物および方法 |
| EP3730126B1 (en) * | 2017-12-22 | 2025-05-14 | Samsung Bioepis Co., Ltd. | Liquid composition comprising vegf antagonist |
| US11524053B2 (en) | 2018-01-26 | 2022-12-13 | The Regents Of The University Of California | Methods and compositions for treatment of angiogenic disorders using anti-VEGF agents |
| CA3092588A1 (en) | 2018-03-02 | 2019-09-06 | Kodiak Sciences Inc. | Il-6 antibodies and fusion constructs and conjugates thereof |
| WO2019173767A1 (en) | 2018-03-08 | 2019-09-12 | Coherus Biosciences Inc. | Stable aqueous formulations of aflibercept |
| US11426446B2 (en) | 2018-03-08 | 2022-08-30 | Coherus Biosciences, Inc. | Stable aqueous formulations of aflibercept |
| US20210169871A1 (en) * | 2018-04-05 | 2021-06-10 | Tarveda Therapeutics, Inc. | Pharmaceutical compositions with reduced tert-butanol levels |
| JP7855312B2 (ja) | 2018-04-27 | 2026-05-08 | ノバリック ゲーエムベーハー | 緑内障の治療のためのタフルプロストを含む眼科用組成物 |
| TWI903214B (zh) | 2018-05-02 | 2025-11-01 | 美商里珍納龍藥品有限公司 | 用於評估生化過濾器的適合性的方法 |
| RS67656B1 (sr) | 2018-05-10 | 2026-02-27 | Regeneron Pharma | Formulacije koje sadrže visoke koncentracije fuzionog proteina vegf receptora |
| US11519020B2 (en) | 2018-05-25 | 2022-12-06 | Regeneron Pharmaceuticals, Inc. | Methods of associating genetic variants with a clinical outcome in patients suffering from age-related macular degeneration treated with anti-VEGF |
| TWI919355B (zh) | 2018-07-02 | 2026-03-21 | 美商里珍納龍藥品有限公司 | 自混合物製備多肽之系統及方法 |
| EP3856245A4 (en) | 2018-09-24 | 2022-10-26 | EyePoint Pharmaceuticals, Inc. | MULTISPECIFIC ANTIBODIES AGAINST HPTP - BETA (VE-PTP) AND VEGF |
| US20210353713A1 (en) | 2018-10-26 | 2021-11-18 | Amgen Inc. | Formulations comprising a tris buffer and a protein |
| WO2020109343A1 (en) | 2018-11-29 | 2020-06-04 | F. Hoffmann-La Roche Ag | Combination therapy for treatment of macular degeneration |
| EP3923907B1 (en) | 2019-02-13 | 2024-09-25 | Novaliq GmbH | Compositions and methods for the treatment of ocular neovascularization |
| EA202192422A1 (ru) | 2019-03-05 | 2021-12-09 | Ридженерон Фармасьютикалз, Инк. | Человеческий сывороточный альбумин в составах |
| PE20240329A1 (es) | 2019-06-05 | 2024-02-27 | Regeneron Pharma | Dispositivos y metodos para administracion de dosis de precision |
| KR102286892B1 (ko) * | 2019-07-08 | 2021-08-06 | 삼천당제약주식회사 | 안과용 단백질 제제의 정제방법 |
| UY38819A (es) * | 2019-08-01 | 2021-02-26 | Gennova Biopharmaceuticals Ltd | Composición oftálmica de bevacizumab |
| WO2021050687A1 (en) | 2019-09-10 | 2021-03-18 | Coherus Biosciences, Inc. | Stable aqueous formulations of aflibercept |
| MX2022002980A (es) | 2019-09-16 | 2022-04-06 | Amgen Inc | Metodo para la esterilizacion externa de un dispositivo de suministro de farmacos. |
| CA3157509A1 (en) | 2019-10-10 | 2021-04-15 | Kodiak Sciences Inc. | Methods of treating an eye disorder |
| CN114867487A (zh) | 2019-11-25 | 2022-08-05 | 加利福尼亚大学董事会 | 用于眼内新生血管的长效vegf抑制剂 |
| IL309560B2 (en) | 2019-12-06 | 2025-05-01 | Regeneron Pharma | Anti-VEGF protein preparations and methods for their production |
| MX2022013812A (es) | 2020-05-08 | 2022-12-15 | Regeneron Pharma | Trampas y mini-trampas de vegf y metodos para el tratamiento de trastornos oculares y cancer. |
| WO2021231463A1 (en) | 2020-05-11 | 2021-11-18 | Regeneron Pharmaceuticals, Inc. | Viral clearance by low ph hold |
| EP4186492B1 (en) | 2020-07-24 | 2026-01-21 | Pangen Biotech Inc. | Ophthalmic liquid composition |
| EP4190310A4 (en) * | 2020-07-31 | 2024-01-17 | Celltrion, Inc. | Stable pharmaceutical preparation |
| CN112245569B (zh) * | 2020-11-18 | 2024-05-28 | 通化东宝药业股份有限公司 | 一种稳定的阿柏西普制剂及其制备方法 |
| KR102720956B1 (ko) * | 2020-12-15 | 2024-10-24 | 삼천당제약주식회사 | 안과용 제형을 포함하는 시린지 |
| IL303675A (en) | 2020-12-17 | 2023-08-01 | Regeneron Pharma | Production of protein thermal microgels |
| FI4185318T3 (fi) | 2021-05-17 | 2025-10-13 | Regeneron Pharma | Pitkäaikaisia, suuren annoksen VEGF-antagonistihoitoja angiogeenisten silmäsairauksien hoitoon |
| US12649031B2 (en) | 2021-09-08 | 2026-06-09 | Regeneron Pharmaceuticals, Inc. | Methods for delivering agents with pre-filled syringes to minimize intraocular inflammation |
| WO2023153535A1 (ko) * | 2022-02-09 | 2023-08-17 | 삼천당제약주식회사 | 안과용 제형을 포함하는 시린지 |
| US11723955B1 (en) * | 2022-05-13 | 2023-08-15 | Allgenesis Biotherapeutics Inc. | VEGFR fusion protein pharmaceutical composition |
| USD1120314S1 (en) | 2022-11-30 | 2026-03-24 | Regeneron Pharmaceuticals, Inc. | Dose delivery device |
| WO2025176843A1 (en) | 2024-02-21 | 2025-08-28 | Ags Therapeutics Sas | Microalgae extracellular vesicle based gene therapy vectors (mev-gtvs), their preparation, and uses thereof |
| WO2025227916A1 (zh) | 2024-04-29 | 2025-11-06 | 齐鲁制药有限公司 | 包含阿柏西普和其变体的组合物以及相关方法和应用 |
| US12240888B1 (en) | 2024-04-29 | 2025-03-04 | QILU Pharmaceutical, Co., Ltd. | Composition comprising aflibercept and a variant thereof, and related methods and uses |
Family Cites Families (86)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1046492A (en) | 1907-11-14 | 1912-12-10 | Walter Chisholm Ranson | Flushing apparatus. |
| JPH03504499A (ja) | 1988-05-27 | 1991-10-03 | セントカー・インコーポレーテツド | 抗体試薬のための配合物 |
| AU2309692A (en) | 1991-07-03 | 1993-02-11 | Cryolife, Inc. | Method for stabilization of biomaterials |
| WO1993022336A1 (en) | 1992-04-30 | 1993-11-11 | Alpha Therapeutic Corporation | Improved solubilization and stabilization of factor viii complex |
| ATE198277T1 (de) | 1992-10-02 | 2001-01-15 | Genetics Inst | Zusammensetzung, welche den koagulationsfaktor viii beinhaltet; verfahren zu deren herstellung und die benutzung eines oberflächenaktiven stoffes als stabilisator |
| US6177401B1 (en) | 1992-11-13 | 2001-01-23 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften | Use of organic compounds for the inhibition of Flk-1 mediated vasculogenesis and angiogenesis |
| GB9410534D0 (en) | 1994-05-26 | 1994-07-13 | Lynxvale Ltd | Improvements in or relating to growth factor inhibitors |
| US5656730A (en) | 1995-04-07 | 1997-08-12 | Enzon, Inc. | Stabilized monomeric protein compositions |
| US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
| US6685940B2 (en) | 1995-07-27 | 2004-02-03 | Genentech, Inc. | Protein formulation |
| CA2226575C (en) | 1995-07-27 | 2011-10-18 | Genentech, Inc. | Stabile isotonic lyophilized protein formulation |
| JPH09154588A (ja) | 1995-10-07 | 1997-06-17 | Toagosei Co Ltd | Ｖｅｇｆ結合性ポリペプチド |
| US5770700A (en) | 1996-01-25 | 1998-06-23 | Genetics Institute, Inc. | Liquid factor IX formulations |
| US6100071A (en) | 1996-05-07 | 2000-08-08 | Genentech, Inc. | Receptors as novel inhibitors of vascular endothelial growth factor activity and processes for their production |
| US5763401A (en) | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
| US7312196B2 (en) | 1997-01-08 | 2007-12-25 | Amylin Pharmaceuticals, Inc. | Formulations for amylin agonist peptides |
| JPH10273450A (ja) * | 1997-03-27 | 1998-10-13 | Toagosei Co Ltd | 眼内血管新生性疾患治療薬 |
| DE69829891T2 (de) | 1997-04-07 | 2005-10-06 | Genentech, Inc., South San Francisco | Anti-VEGF Antikörper |
| US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
| US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
| JPH1180024A (ja) | 1997-09-12 | 1999-03-23 | Toagosei Co Ltd | 角膜血管新生阻害剤 |
| US6436897B2 (en) * | 1998-06-01 | 2002-08-20 | Celtrix Pharmaceuticals, Inc. | Pharmaceutical formulations for IGF/IGFBP |
| US6472179B2 (en) | 1998-09-25 | 2002-10-29 | Regeneron Pharmaceuticals, Inc. | Receptor based antagonists and methods of making and using |
| US6927044B2 (en) | 1998-09-25 | 2005-08-09 | Regeneron Pharmaceuticals, Inc. | IL-1 receptor based cytokine traps |
| IL145675A0 (en) | 1999-04-16 | 2002-06-30 | Genentech Inc | Vascular endothelial cell growth factor variants and uses thereof |
| EP1179541B1 (en) | 1999-04-28 | 2004-06-16 | Board Of Regents, The University Of Texas System | Compositions and methods for cancer treatment by selectively inhibiting VEGF |
| US7087411B2 (en) | 1999-06-08 | 2006-08-08 | Regeneron Pharmaceuticals, Inc. | Fusion protein capable of binding VEGF |
| US7303746B2 (en) | 1999-06-08 | 2007-12-04 | Regeneron Pharmaceuticals, Inc. | Methods of treating eye disorders with modified chimeric polypeptides |
| CN101433715B (zh) | 1999-06-08 | 2013-04-17 | 里珍纳龙药品有限公司 | 具有改善的药物动力学特性的修饰嵌合多肽 |
| US7070959B1 (en) | 1999-06-08 | 2006-07-04 | Regeneron Pharmaceuticals, Inc. | Modified chimeric polypeptides with improved pharmacokinetic properties |
| US6833349B2 (en) | 1999-06-08 | 2004-12-21 | Regeneron Pharmaceuticals, Inc. | Methods of treating inflammatory skin diseases |
| US7396664B2 (en) | 1999-06-08 | 2008-07-08 | Regeneron Pharmaceuticals, Inc. | VEGF-binding fusion proteins and nucleic acids encoding the same |
| US7306799B2 (en) | 1999-06-08 | 2007-12-11 | Regeneron Pharmaceuticals, Inc. | Use of VEGF inhibitors for treatment of eye disorders |
| US7001892B1 (en) | 1999-06-11 | 2006-02-21 | Purdue Research Foundation | Pharmaceutical materials and methods for their preparation and use |
| US6777429B1 (en) | 1999-07-23 | 2004-08-17 | Novartis Ag | Ophthalmic composition |
| DE60139944D1 (de) | 2000-10-12 | 2009-10-29 | Genentech Inc | Niederviskose konzentrierte proteinformulierungen |
| RU2177801C1 (ru) * | 2001-01-25 | 2002-01-10 | Санкт-Петербургская Общественная Организация "Санкт-Петербургский Институт Биорегуляции И Геронтологии Сзо Рамн" | Средство, ингибирующее ангиогенез при заболеваниях органа зрения |
| GB0113179D0 (en) | 2001-05-31 | 2001-07-25 | Novartis Ag | Organic compounds |
| EP1406700A1 (en) | 2001-07-06 | 2004-04-14 | Sucampo AG | Composition for topical administration comprising an interleukin-2 inhibitor and an antimicrobial agent |
| ATE454137T1 (de) | 2001-07-25 | 2010-01-15 | Facet Biotech Corp | Stabile lyophilisierte pharmazeutische formulierung des igg-antikörpers daclizumab |
| US20030138417A1 (en) | 2001-11-08 | 2003-07-24 | Kaisheva Elizabet A. | Stable liquid pharmaceutical formulation of IgG antibodies |
| HRP20040406A2 (en) * | 2001-11-09 | 2005-02-28 | Eyetech Pharmaceuticals | Methods for treating ocular neovascular diseases |
| CA2476934C (en) | 2002-02-27 | 2009-06-16 | Immunex Corporation | Stabilized tnfr-fc composition comprising arginine |
| JP4730909B2 (ja) | 2003-03-28 | 2011-07-20 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | Ｖｅｇｆ媒介性活性を遮断することにより糖尿病を処置する方法 |
| PT1610820E (pt) | 2003-04-04 | 2010-12-16 | Novartis Ag | Formulações de elevada concentração de anticorpos e proteínas |
| US20040266688A1 (en) | 2003-05-14 | 2004-12-30 | Nayak Nihar R | Methods for modulating endometrium |
| AU2004242586C1 (en) | 2003-05-28 | 2011-02-24 | Regeneron Pharmaceuticals, Inc. | Method of treating corneal transplant rejection by using VEGF antagonists |
| RS20150135A1 (sr) | 2003-05-30 | 2015-08-31 | Genentech Inc. | Tretman sa anti-vegf antitelima |
| CA2519875C (en) | 2003-06-06 | 2014-01-14 | Regeneron Pharmaceuticals, Inc. | Method of tumor regression with vegf inhibitors |
| AR046510A1 (es) * | 2003-07-25 | 2005-12-14 | Regeneron Pharma | Composicion de un antagonista de vegf y un agente anti-proliferativo |
| JP2007501239A (ja) | 2003-08-06 | 2007-01-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 放射線治療と組み合わせたｖｅｇｆアンタゴニストの使用 |
| NZ592039A (en) * | 2003-08-27 | 2013-03-28 | Ophthotech Corp | Combination therapy for the treatment of ocular neovascular disorders |
| WO2005072772A1 (en) | 2004-01-30 | 2005-08-11 | Suomen Punainen Risti Veripalvelu | Pharmaceutical compositions |
| US7422741B2 (en) | 2004-03-05 | 2008-09-09 | Vegenics Limited | VEGFR-3 fusion proteins |
| WO2005102303A2 (en) | 2004-04-21 | 2005-11-03 | Advanced Ocular Systems Limited | Antiprostaglandins for the treatment of ocular pathologies |
| CN100361710C (zh) | 2004-06-07 | 2008-01-16 | 成都康弘生物科技有限公司 | 肿瘤细胞专一表达免疫调节因子gm-csf的溶瘤性腺病毒重组体的构建及其应用 |
| ES2381014T3 (es) | 2004-06-08 | 2012-05-22 | Chengdu Kanghong Biotechnologies Co., Ltd. | Proteína quimérica inhibidora de la angiogénesis y el uso |
| CN1304427C (zh) | 2004-06-08 | 2007-03-14 | 成都康弘生物科技有限公司 | 抑制血管新生的融合蛋白质及其用途 |
| EP2583685A1 (en) | 2004-06-10 | 2013-04-24 | Regeneron Pharmaceuticals, Inc. | Method of administering and using VEGF inhibitors for the treatment of human cancer |
| EP1755645A2 (en) | 2004-06-18 | 2007-02-28 | Regeneron Pharmaceuticals, Inc. | Vegf inhibitors for the treatment of malignant pleural effusion |
| US20060008415A1 (en) | 2004-06-25 | 2006-01-12 | Protein Design Labs, Inc. | Stable liquid and lyophilized formulation of proteins |
| CN1997386B (zh) | 2004-07-30 | 2012-05-30 | 瑞泽恩制药公司 | 通过阻断vegf介导的活性来治疗i型糖尿病的方法 |
| ES2395035T3 (es) | 2004-08-17 | 2013-02-07 | Regeneron Pharmaceuticals, Inc. | Formulaciones de antagonistas de la IL-1 |
| WO2006043965A1 (en) | 2004-10-14 | 2006-04-27 | Allergan, Inc. | Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods |
| PT1802334E (pt) | 2004-10-21 | 2012-11-28 | Genentech Inc | Método para tratamento de doenças neovasculares intraoculares |
| EP1877438A2 (en) | 2005-02-02 | 2008-01-16 | Regeneron Pharmaceuticals, Inc. | Method of treating eye injury with local administration of a vegf inhibitor |
| CA3142945A1 (en) | 2005-03-25 | 2006-10-05 | Regeneron Pharmaceuticals, Inc. | Histidine-buffered formulations of vegf antagonist |
| JP2008543839A (ja) | 2005-06-14 | 2008-12-04 | アムジェン インコーポレーテッド | 自己緩衝タンパク質製剤 |
| CN100502945C (zh) | 2006-03-31 | 2009-06-24 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在治疗眼睛疾病中的应用 |
| CN100567325C (zh) | 2006-03-31 | 2009-12-09 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白及其在制备治疗眼睛疾病的药物中的应用 |
| US8216575B2 (en) | 2006-03-31 | 2012-07-10 | Chengdu Kanghong Biotechnologies Co., Ltd. | Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains |
| CA2654510C (en) | 2006-06-16 | 2015-03-17 | Regeneron Pharmaceuticals, Inc. | Vegf antagonist formulations suitable for intravitreal administration |
| US8642067B2 (en) | 2007-04-02 | 2014-02-04 | Allergen, Inc. | Methods and compositions for intraocular administration to treat ocular conditions |
| US11078262B2 (en) | 2007-04-30 | 2021-08-03 | Allergan, Inc. | High viscosity macromolecular compositions for treating ocular conditions |
| US20090202855A1 (en) | 2008-01-09 | 2009-08-13 | Saxton David M | Porous sliding bearing and method of construction thereof |
| WO2010125416A1 (en) | 2009-04-27 | 2010-11-04 | Raouf Rekik | Drug delivery to the anterior and posterior segments of the eye |
| CN102233132B (zh) | 2010-04-28 | 2013-10-23 | 成都康弘生物科技有限公司 | Vegf受体融合蛋白在制备抑制眼表新生血管生长的药物中的应用 |
| CN102380096B (zh) | 2010-08-31 | 2014-04-30 | 成都康弘生物科技有限公司 | 一种含有抑制血管增生的融合蛋白的药物组合物及用途 |
| CN107115294B (zh) | 2012-01-19 | 2019-10-18 | 北京康弘生物医药有限公司 | 一种含有vegf拮抗剂的滴眼液 |
| DE202013000688U1 (de) | 2012-07-03 | 2013-03-05 | Novartis Ag | Glas-Spritze |
| JP6071099B1 (ja) | 2014-01-25 | 2017-02-01 | ツェンドゥー カンホン バイオテクノロジーズ カンパニー リミテッド | 血管の新生又は成長を抑制する融合タンパク質及びその用途 |
| US20160144025A1 (en) | 2014-11-25 | 2016-05-26 | Regeneron Pharmaceuticals, Inc. | Methods and formulations for treating vascular eye diseases |
| EP3407868A1 (en) | 2016-01-26 | 2018-12-05 | Formycon AG | Liquid formulation of a vegf antagonist |
| CN109937034B (zh) | 2016-11-21 | 2022-09-16 | 济世-伊沃泰克生物制品有限公司 | 阿柏西普制剂及其用途 |
| KR101861163B1 (ko) | 2017-04-26 | 2018-05-25 | 삼천당제약주식회사 | 안과용 약학 조성물 |
| EP3730126B1 (en) | 2017-12-22 | 2025-05-14 | Samsung Bioepis Co., Ltd. | Liquid composition comprising vegf antagonist |
-
2007
- 2007-06-14 CA CA2654510A patent/CA2654510C/en active Active
- 2007-06-14 ES ES15169936T patent/ES2861898T3/es active Active
- 2007-06-14 DK DK15169936.0T patent/DK2944306T3/da active
- 2007-06-14 ES ES11157965T patent/ES2406764T3/es active Active
- 2007-06-14 HU HUE15169936A patent/HUE053612T2/hu unknown
- 2007-06-14 EP EP07809593A patent/EP2029103A2/en not_active Withdrawn
- 2007-06-14 MX MX2008016124A patent/MX2008016124A/es active IP Right Grant
- 2007-06-14 PT PT151699360T patent/PT2944306T/pt unknown
- 2007-06-14 HU HUE11157965A patent/HUE018715T2/hu unknown
- 2007-06-14 RU RU2009101226A patent/RU2432155C3/ru active
- 2007-06-14 DK DK11157965.2T patent/DK2364691T3/da active
- 2007-06-14 US US11/818,463 patent/US7608261B2/en active Active
- 2007-06-14 PL PL11157965T patent/PL2364691T3/pl unknown
- 2007-06-14 EP EP20178021.0A patent/EP3753548A1/en active Pending
- 2007-06-14 KR KR1020087029933A patent/KR101406811B1/ko active Active
- 2007-06-14 SI SI200732171T patent/SI2944306T1/sl unknown
- 2007-06-14 CN CNA2007800225554A patent/CN101478949A/zh active Pending
- 2007-06-14 AU AU2007261536A patent/AU2007261536C1/en active Active
- 2007-06-14 EP EP15169936.0A patent/EP2944306B1/en active Active
- 2007-06-14 JP JP2009515517A patent/JP5216002B2/ja active Active
- 2007-06-14 WO PCT/US2007/014085 patent/WO2007149334A2/en not_active Ceased
- 2007-06-14 SI SI200731264T patent/SI2364691T1/sl unknown
- 2007-06-14 CN CN201410707259.XA patent/CN104434770A/zh active Pending
- 2007-06-14 EP EP11157965.2A patent/EP2364691B1/en active Active
- 2007-06-14 BR BRPI0713749A patent/BRPI0713749B8/pt active Search and Examination
- 2007-06-14 LT LTEP15169936.0T patent/LT2944306T/lt unknown
- 2007-06-14 PT PT111579652T patent/PT2364691E/pt unknown
- 2007-06-14 PL PL15169936T patent/PL2944306T3/pl unknown
-
2008
- 2008-11-18 ZA ZA2008/09827A patent/ZA200809827B/en unknown
- 2008-12-08 IL IL195788A patent/IL195788A/en active IP Right Grant
-
2009
- 2009-09-16 US US12/560,885 patent/US7807164B2/en active Active
-
2010
- 2010-07-09 US US12/833,417 patent/US8092803B2/en active Active
-
2011
- 2011-12-19 US US13/329,770 patent/US8481046B2/en active Active
-
2013
- 2013-03-01 JP JP2013040234A patent/JP5597271B2/ja active Active
- 2013-06-11 US US13/914,996 patent/US8802107B2/en active Active
- 2013-07-15 CY CY20131100595T patent/CY1114244T1/el unknown
-
2014
- 2014-07-14 US US14/330,096 patent/US9340594B2/en active Active
-
2015
- 2015-06-02 HK HK15105252.5A patent/HK1204580A1/xx unknown
-
2016
- 2016-04-11 US US15/095,606 patent/US9914763B2/en not_active Expired - Fee Related
- 2016-05-11 US US15/151,776 patent/US9580489B2/en active Active
-
2018
- 2018-01-24 US US15/879,294 patent/US10400025B2/en active Active
- 2018-10-12 US US16/159,269 patent/US10464992B2/en active Active
-
2019
- 2019-09-25 US US16/582,486 patent/US11066458B2/en active Active
-
2020
- 2020-01-10 US US16/739,559 patent/US11084865B2/en active Active
-
2021
- 2021-03-22 CY CY20211100247T patent/CY1124265T1/el unknown
- 2021-06-15 US US17/348,438 patent/US11732024B2/en active Active
-
2023
- 2023-06-29 US US18/344,786 patent/US20230374108A1/en not_active Abandoned
-
2024
- 2024-10-23 US US18/924,707 patent/US12331099B2/en active Active
-
2025
- 2025-04-11 US US19/176,527 patent/US20250257118A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2009101226A (ru) | Составы антагониста vegf, подходящие для интравитреального введения | |
| JP2013079270A5 (enExample) | ||
| JP4789698B2 (ja) | 因子ｉｘ用処方 | |
| RU2011127913A (ru) | Составы, содержащие антитела | |
| JP5752671B2 (ja) | Ｖｅｇｆアンタゴニスト製剤 | |
| US20190388348A1 (en) | Compositions and methods for treating cardiovascular and pulmonary diseases with apelin | |
| JP2000504327A (ja) | 高度に濃縮された、凍結乾燥された、および液体の、因子▲ｉｘ▼処方 | |
| JP2005526084A5 (enExample) | ||
| JP2009524595A5 (enExample) | ||
| JP2012515221A5 (enExample) | ||
| JP2015231997A5 (enExample) | ||
| US20010031721A1 (en) | Highly concentrated, lyophilized, and liquid factor IX formulations | |
| JP2021503485A5 (enExample) | ||
| JP2016533345A5 (enExample) | ||
| JP2017510585A5 (enExample) | ||
| JP2008510716A (ja) | Ｉｌ−１アンタゴニスト製剤 | |
| JP2008510716A5 (enExample) | ||
| ES2595160T3 (es) | Uso combinado de un glucosaminoglicano sulfatado y una hialuronidasa para mejorar la biodisponibilidad del Factor VIII | |
| KR101710471B1 (ko) | 건조한 트랜스글루타미나제 조성물 | |
| ES2449044T3 (es) | Procedimiento de administración de fVIII sin dominio B porcino | |
| US20260124245A1 (en) | Methods and compositions for using leucine zippers for crosslinking of cells and drug carriers | |
| IL316880A (en) | Freeze-dried RNA composition (lyophilization) | |
| NZ733837B2 (en) | Pharmaceutical composition comprising plasminogen and uses thereof |