JP2016520075A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016520075A5 JP2016520075A5 JP2016513387A JP2016513387A JP2016520075A5 JP 2016520075 A5 JP2016520075 A5 JP 2016520075A5 JP 2016513387 A JP2016513387 A JP 2016513387A JP 2016513387 A JP2016513387 A JP 2016513387A JP 2016520075 A5 JP2016520075 A5 JP 2016520075A5
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- formulation
- vwf
- binding agent
- tween
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018209611A JP6952019B2 (ja) | 2013-05-17 | 2018-11-07 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361824523P | 2013-05-17 | 2013-05-17 | |
| US61/824,523 | 2013-05-17 | ||
| PCT/EP2014/060107 WO2014184352A1 (en) | 2013-05-17 | 2014-05-16 | Stable formulations of immunoglobulin single variable domains and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018209611A Division JP6952019B2 (ja) | 2013-05-17 | 2018-11-07 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520075A JP2016520075A (ja) | 2016-07-11 |
| JP2016520075A5 true JP2016520075A5 (enExample) | 2017-06-15 |
| JP6433986B2 JP6433986B2 (ja) | 2018-12-05 |
Family
ID=49304267
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513387A Active JP6433986B2 (ja) | 2013-05-17 | 2014-05-16 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
| JP2018209611A Active JP6952019B2 (ja) | 2013-05-17 | 2018-11-07 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018209611A Active JP6952019B2 (ja) | 2013-05-17 | 2018-11-07 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US10035862B2 (enExample) |
| EP (2) | EP2996720B1 (enExample) |
| JP (2) | JP6433986B2 (enExample) |
| KR (1) | KR102166399B1 (enExample) |
| CN (3) | CN110063935B (enExample) |
| AU (3) | AU2014267222B2 (enExample) |
| BR (1) | BR112015028411B1 (enExample) |
| CA (1) | CA2912670A1 (enExample) |
| CY (1) | CY1122090T1 (enExample) |
| DK (1) | DK2996720T3 (enExample) |
| ES (2) | ES2895150T3 (enExample) |
| HR (1) | HRP20190954T1 (enExample) |
| HU (1) | HUE044392T2 (enExample) |
| LT (1) | LT2996720T (enExample) |
| MX (2) | MX387527B (enExample) |
| NL (1) | NL1040254C2 (enExample) |
| PH (1) | PH12015502591B1 (enExample) |
| PL (2) | PL2996720T3 (enExample) |
| PT (2) | PT3511018T (enExample) |
| RS (1) | RS58857B1 (enExample) |
| RU (1) | RU2671977C2 (enExample) |
| SI (1) | SI2996720T1 (enExample) |
| SM (1) | SMT201900359T1 (enExample) |
| TR (1) | TR201908663T4 (enExample) |
| WO (1) | WO2014184352A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1040254C2 (en) * | 2013-05-17 | 2014-11-24 | Ablynx Nv | Stable formulations of immunoglobulin single variable domains and uses thereof. |
| CN107406497A (zh) | 2014-12-19 | 2017-11-28 | 埃博灵克斯股份有限公司 | 半胱氨酸连接的纳米抗体二聚体 |
| CN111035754A (zh) * | 2016-03-23 | 2020-04-21 | 兆科药业（合肥）有限公司 | 抗血小板溶栓素在制备治疗血栓性血小板减少性紫癜的药物中的应用 |
| GB201612043D0 (en) | 2016-07-11 | 2016-08-24 | Crescendo Biologics Ltd | Composition for treatment of disorders |
| WO2018085551A2 (en) * | 2016-11-02 | 2018-05-11 | Polaris Group | Formulations of pegylated arginine deiminase |
| CN111670202A (zh) | 2018-02-06 | 2020-09-15 | 埃博灵克斯股份有限公司 | 以免疫球蛋白单可变结构域治疗ttp初次发作的方法 |
| RS67043B1 (sr) | 2018-07-03 | 2025-08-29 | Fennec Pharmaceuticals Inc | Formulacije anhidrovanog natrijum tiosulfata |
| JP7653352B2 (ja) * | 2018-09-05 | 2025-03-28 | エクスプレステック、リミテッド、ライアビリティ、カンパニー | 免疫グロブリンａ製剤 |
| MY205764A (en) * | 2018-10-10 | 2024-11-12 | Astellas Pharma Inc | Pharmaceutical composition containing tagged site-antihuman antibody fab fragment complex |
| CN110564841A (zh) * | 2019-09-19 | 2019-12-13 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 脑缺血相关基因作为缺血性卒中行为学特征分析的生物标记的应用 |
| CN110624105B (zh) * | 2019-09-24 | 2021-06-11 | 苏州大学 | 血管性血友病因子的结构敏感多肽抗原的序列 |
| JP7502861B2 (ja) * | 2019-12-27 | 2024-06-19 | 旭化成株式会社 | 標的物質と両親媒性高分子との複合体の形成反応の反応温度の評価方法 |
| CN113908254B (zh) * | 2021-10-19 | 2024-05-28 | 山西锦波生物医药股份有限公司 | 一种干粉吸入剂及其制备方法和用途 |
| CN115850493B (zh) * | 2022-11-08 | 2024-03-12 | 江苏耀海生物制药有限公司 | 一种二价纳米抗体Cablivi的分离纯化方法 |
| WO2025240928A1 (en) * | 2024-05-16 | 2025-11-20 | Vega Therapeutics, Inc. | Treatment of von willebrand disease |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1621554E (pt) | 1992-08-21 | 2009-07-13 | Univ Bruxelles | Imunoglobtainas desprovidas de cadeias leves |
| US6838254B1 (en) | 1993-04-29 | 2005-01-04 | Conopco, Inc. | Production of antibodies or (functionalized) fragments thereof derived from heavy chain immunoglobulins of camelidae |
| FR2708622B1 (fr) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
| NZ285664A (en) | 1994-05-18 | 1998-07-28 | Inhale Therapeutic Syst | Dry powder interferon composition adapted for pulmonary delivery |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| JP2000515002A (ja) | 1996-06-27 | 2000-11-14 | フラームス・インテルウニフェルジテール・インスティテュート・フォール・ビオテヒノロジー・ヴェーゼットウェー | 標的分子の活性部位またはクレフトと特異的に相互作用する認識分子 |
| US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
| WO1999023221A2 (en) | 1997-10-27 | 1999-05-14 | Unilever Plc | Multivalent antigen-binding proteins |
| WO1999037681A2 (en) | 1998-01-26 | 1999-07-29 | Unilever Plc | Method for producing antibody fragments |
| EP0967284A1 (en) | 1998-05-28 | 1999-12-29 | Pfizer Limited | Phosphodiesterases |
| WO2000040968A1 (en) | 1999-01-05 | 2000-07-13 | Unilever Plc | Binding of antibody fragments to solid supports |
| AU2291700A (en) | 1999-01-19 | 2000-08-07 | Unilever Plc | Method for producing antibody fragments |
| NZ513356A (en) | 1999-02-05 | 2004-01-30 | Univ Leiden | Method of modulating metabolite biosynthesis in recombinant cells using an AP2-domain transcription factor that is involved in the response of a plant cell to a jasmonate |
| US6617122B1 (en) | 1999-03-15 | 2003-09-09 | Xenon Genetics, Inc. | Process for identifying modulators of ABC1 activity |
| CN1252264C (zh) | 1999-04-22 | 2006-04-19 | 荷兰联合利华有限公司 | 利用单价抗原－结合蛋白抑制病毒感染 |
| ATE422545T1 (de) | 1999-06-18 | 2009-02-15 | Cv Therapeutics Inc | Regulierung mittels atp binding cassette transporter proteins abc1 |
| EP1198572A2 (en) | 1999-08-02 | 2002-04-24 | Keygene N.V. | Method for generating cgmmv resistant plants, genetic constructs, and obtained cgmmv-resistant plants |
| GB9922124D0 (en) | 1999-09-17 | 1999-11-17 | Pfizer Ltd | Phosphodiesterase enzymes |
| US6479280B1 (en) | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
| DE19955408A1 (de) | 1999-11-18 | 2001-05-23 | Bayer Ag | GABA-B-Rezeptoren |
| EP1242460B1 (en) | 1999-11-29 | 2006-10-18 | Unilever Plc | Immobilisation of proteins using a polypeptide segment |
| WO2001044301A1 (en) | 1999-11-29 | 2001-06-21 | Unilever Plc | Immobilized single domain antigen-binding molecules |
| EP1134231B1 (en) | 2000-03-14 | 2009-04-15 | Unilever N.V. | Antibody heavy chain variable domains against human dietary lipases, and their uses |
| US20030190598A1 (en) | 2000-05-26 | 2003-10-09 | Jasmid Tanha | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| ATE513854T1 (de) | 2000-12-13 | 2011-07-15 | Bac Ip B V | Proteinraster aus variablen domänen der schweren immunoglobulinkette von kamelen |
| CA2457636C (en) | 2001-08-10 | 2012-01-03 | Aberdeen University | Antigen binding domains |
| US7371849B2 (en) | 2001-09-13 | 2008-05-13 | Institute For Antibodies Co., Ltd. | Methods of constructing camel antibody libraries |
| US6723359B2 (en) | 2001-10-18 | 2004-04-20 | Firmenich Sa | Spray-dried compositions and method for their preparation |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| US20050214857A1 (en) | 2001-12-11 | 2005-09-29 | Algonomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| JP4323317B2 (ja) | 2001-12-21 | 2009-09-02 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー（ヴェーイーベー・ヴェーゼットウェー） | 可変領域配列のクローニング方法 |
| WO2003055527A2 (en) | 2002-01-03 | 2003-07-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Immunoconjugates useful for treatment of tumours |
| GB0202633D0 (en) * | 2002-02-05 | 2002-03-20 | Delta Biotechnology Ltd | Stabilization of protein preparations |
| AU2003251238A1 (en) | 2002-08-07 | 2004-02-25 | Umc Utrecht Holding B.V. | Modulation of platelet adhesion based on the surface exposed beta-switch loop of platelet glycoprotein ib-alpha |
| BRPI0315666B8 (pt) | 2002-10-23 | 2021-05-25 | Ludwig Inst For Cancer Res Ltd | dna de a34 e a33 do tipo 3, proteínas, seus anticorpos e métodos de tratamento usando os mesmos |
| EP1558647B1 (en) | 2002-11-08 | 2015-06-10 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| EP2284192A3 (en) | 2002-11-08 | 2011-07-20 | Ablynx N.V. | Camelidae antibodies for sublingual administration |
| PT1687338E (pt) | 2003-11-07 | 2011-01-20 | Ablynx Nv | Anticorpos de domínio único vhh de camelídeos direccionados para o receptor do factor de crescimento epidérmico e suas utilizações |
| WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| CA2593328C (en) | 2005-01-14 | 2018-02-06 | Ablynx N.V. | Methods and assays for distinguishing between different forms of diseases and disorders characterized by thrombocytopenia and/or by spontaneous interaction between von willebrand factor (vwf) and platelets |
| CA2595682A1 (en) | 2005-01-31 | 2006-08-03 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
| AU2006249144B2 (en) | 2005-05-18 | 2011-11-17 | Ablynx Nv | Improved NanobodiesTM against Tumor Necrosis Factor-alpha |
| MX2007014564A (es) | 2005-05-20 | 2008-02-07 | Ablynx Nv | Anticuerpos de vhh de dominio unico contra el factor de von willebrand. |
| AU2006256030B2 (en) * | 2005-06-10 | 2012-06-21 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical compositions containing sc(Fv)2 |
| EP2004690A2 (en) | 2006-03-13 | 2008-12-24 | Ablynx N.V. | Amino acid sequences directed against il-6 and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| WO2008068280A1 (en) | 2006-12-05 | 2008-06-12 | Ablynx N.V. | Peptides capable of binding to serum proteins |
| MX2009010179A (es) * | 2007-03-22 | 2010-03-15 | Imclone Llc | Formulaciones estables de anticuerpo. |
| WO2009086400A2 (en) * | 2007-12-28 | 2009-07-09 | Baxter International Inc. | Recombinant vwf formulations |
| EP2249809A1 (en) * | 2008-01-15 | 2010-11-17 | Abbott GmbH & Co. KG | Powdered protein compositions and methods of making same |
| CA2718081A1 (en) * | 2008-03-21 | 2009-09-24 | Ablynx Nv | Von willebrand factor specific binders and methods of use therefor |
| CN102089325A (zh) | 2008-04-17 | 2011-06-08 | 埃博灵克斯股份有限公司 | 能够结合血清白蛋白的肽，以及包含其的化合物、构建体和多肽 |
| DK2349314T3 (da) * | 2008-10-21 | 2013-05-27 | Baxter Int | Lyofiliserede præparater af rekombinant VWF |
| KR101593285B1 (ko) * | 2008-10-29 | 2016-02-11 | 아블린쓰 엔.브이. | 단일 도메인 항원 결합 분자의 제형 |
| EP2196476A1 (en) * | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
| US20120321640A1 (en) | 2009-12-01 | 2012-12-20 | Ablynx N.V. | Von willebrand factor specific binding agents and uses thereof |
| CN102781959A (zh) | 2010-02-05 | 2012-11-14 | 埃博灵克斯股份有限公司 | 能够结合血清白蛋白的肽和包含所述肽的化合物、构建体和多肽 |
| ES2738114T3 (es) * | 2010-02-11 | 2020-01-20 | Ablynx Nv | Métodos y composiciones para la preparación de aerosoles |
| US20120225072A1 (en) * | 2011-03-02 | 2012-09-06 | Ablynx N.V. | Stable formulations of immunoglobulin single variable domains and uses thereof |
| NL1040254C2 (en) * | 2013-05-17 | 2014-11-24 | Ablynx Nv | Stable formulations of immunoglobulin single variable domains and uses thereof. |
-
2013
- 2013-06-14 NL NL1040254A patent/NL1040254C2/en active
-
2014
- 2014-05-16 JP JP2016513387A patent/JP6433986B2/ja active Active
- 2014-05-16 MX MX2019005269A patent/MX387527B/es unknown
- 2014-05-16 RS RS20190694A patent/RS58857B1/sr unknown
- 2014-05-16 CA CA2912670A patent/CA2912670A1/en not_active Abandoned
- 2014-05-16 ES ES19157147T patent/ES2895150T3/es active Active
- 2014-05-16 EP EP14727433.6A patent/EP2996720B1/en active Active
- 2014-05-16 MX MX2015015722A patent/MX364664B/es active IP Right Grant
- 2014-05-16 DK DK14727433.6T patent/DK2996720T3/da active
- 2014-05-16 EP EP19157147.0A patent/EP3511018B1/en active Active
- 2014-05-16 PL PL14727433T patent/PL2996720T3/pl unknown
- 2014-05-16 HR HRP20190954TT patent/HRP20190954T1/hr unknown
- 2014-05-16 RU RU2015154214A patent/RU2671977C2/ru active
- 2014-05-16 AU AU2014267222A patent/AU2014267222B2/en active Active
- 2014-05-16 TR TR2019/08663T patent/TR201908663T4/tr unknown
- 2014-05-16 SI SI201431229T patent/SI2996720T1/sl unknown
- 2014-05-16 ES ES14727433T patent/ES2731922T3/es active Active
- 2014-05-16 CN CN201811423557.0A patent/CN110063935B/zh active Active
- 2014-05-16 CN CN201480034630.9A patent/CN105339003B/zh active Active
- 2014-05-16 US US14/891,441 patent/US10035862B2/en active Active
- 2014-05-16 SM SM20190359T patent/SMT201900359T1/it unknown
- 2014-05-16 PL PL19157147T patent/PL3511018T3/pl unknown
- 2014-05-16 HU HUE14727433 patent/HUE044392T2/hu unknown
- 2014-05-16 PT PT191571470T patent/PT3511018T/pt unknown
- 2014-05-16 WO PCT/EP2014/060107 patent/WO2014184352A1/en not_active Ceased
- 2014-05-16 PT PT14727433T patent/PT2996720T/pt unknown
- 2014-05-16 KR KR1020157035523A patent/KR102166399B1/ko active Active
- 2014-05-16 LT LTEP14727433.6T patent/LT2996720T/lt unknown
- 2014-05-16 BR BR112015028411-6A patent/BR112015028411B1/pt active IP Right Grant
- 2014-05-16 CN CN201811422890.XA patent/CN110037983A/zh active Pending
-
2015
- 2015-11-16 PH PH12015502591A patent/PH12015502591B1/en unknown
-
2018
- 2018-06-14 US US16/008,103 patent/US20190010249A1/en active Pending
- 2018-11-07 JP JP2018209611A patent/JP6952019B2/ja active Active
-
2019
- 2019-02-25 AU AU2019201307A patent/AU2019201307B2/en active Active
- 2019-06-26 CY CY20191100669T patent/CY1122090T1/el unknown
-
2021
- 2021-01-05 AU AU2021200035A patent/AU2021200035A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2015154214A (ru) | Стабильные композиции иммуноглобулинового одиночного вариабельного домена и их применение | |
| PH12017500844A1 (en) | Stable protein solution formulation containing high concentration of an anti-vegf antibody | |
| JP2015231997A5 (enExample) | ||
| JP2015091902A5 (enExample) | ||
| EA201892446A1 (ru) | Фармацевтическая композиция | |
| JP2016534052A5 (enExample) | ||
| AU2016204371A1 (en) | Lyophilised and aqueous anti-CD40 antibody formulations | |
| PH12014501988A1 (en) | Pharmaceutical formulations of tnf-alpha antibodies | |
| JP2012136518A5 (enExample) | ||
| AR082171A1 (es) | Formulaciones estabilizadas que contienen anticuerpos anti-ngf | |
| TN2009000382A1 (en) | Stable antibody formulations | |
| RU2017101667A (ru) | Фармацевтические композиции | |
| CN102892424A (zh) | 病毒颗粒的稳定 | |
| HRP20201242T1 (hr) | Tekući farmaceutski pripravak | |
| RU2014124143A (ru) | Стабильная композиция антитела, специфически связывающегося с her2 рецепторами, и способ ее получения | |
| HRP20220011T1 (hr) | Nova stabilna formulacija za fxia protutijela | |
| HRP20211838T1 (hr) | Krnji protein vp4 rotavirusa i njegova primjena | |
| EA202092926A2 (ru) | Лиофилизированные составы, содержащие фактор ix | |
| SI2916866T1 (en) | Form for bispecific T-cell activators (BiTE) | |
| RU2019111152A (ru) | Новый способ стабилизации биофармацевтического лекарственного продукта при производстве | |
| JP2016534062A5 (enExample) | ||
| JP2017521370A5 (enExample) | ||
| RU2015135147A (ru) | Композиции доставки с замедленным высвобождением и способ стабилизации белков в процессе изготовления | |
| GR1008818B (el) | Φαρμακευτικο σκευασμα περιεχον εναν αντιμυκητιασικο παραγοντα εχινοκανδινης και μεθοδος παρασκευης αυτου | |
| Hancheol et al. | Identification, cloning, characterization and recombinant expression of alpha-type carbonic anhydrase from Phaeodactylum tricornutum CCMP 632 |