JP2016520075A5 - - Google Patents
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- JP2016520075A5 JP2016520075A5 JP2016513387A JP2016513387A JP2016520075A5 JP 2016520075 A5 JP2016520075 A5 JP 2016520075A5 JP 2016513387 A JP2016513387 A JP 2016513387A JP 2016513387 A JP2016513387 A JP 2016513387A JP 2016520075 A5 JP2016520075 A5 JP 2016520075A5
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- formulation
- vwf
- binding agent
- tween
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018209611A JP6952019B2 (ja) | 2013-05-17 | 2018-11-07 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361824523P | 2013-05-17 | 2013-05-17 | |
| US61/824,523 | 2013-05-17 | ||
| PCT/EP2014/060107 WO2014184352A1 (en) | 2013-05-17 | 2014-05-16 | Stable formulations of immunoglobulin single variable domains and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018209611A Division JP6952019B2 (ja) | 2013-05-17 | 2018-11-07 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016520075A JP2016520075A (ja) | 2016-07-11 |
| JP2016520075A5 true JP2016520075A5 (enExample) | 2017-06-15 |
| JP6433986B2 JP6433986B2 (ja) | 2018-12-05 |
Family
ID=49304267
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016513387A Active JP6433986B2 (ja) | 2013-05-17 | 2014-05-16 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
| JP2018209611A Active JP6952019B2 (ja) | 2013-05-17 | 2018-11-07 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018209611A Active JP6952019B2 (ja) | 2013-05-17 | 2018-11-07 | 免疫グロブリン単一可変ドメインの安定製剤及びその使用 |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US10035862B2 (enExample) |
| EP (2) | EP2996720B1 (enExample) |
| JP (2) | JP6433986B2 (enExample) |
| KR (1) | KR102166399B1 (enExample) |
| CN (3) | CN110063935B (enExample) |
| AU (3) | AU2014267222B2 (enExample) |
| BR (1) | BR112015028411B1 (enExample) |
| CA (1) | CA2912670A1 (enExample) |
| CY (1) | CY1122090T1 (enExample) |
| DK (1) | DK2996720T3 (enExample) |
| ES (2) | ES2895150T3 (enExample) |
| HR (1) | HRP20190954T1 (enExample) |
| HU (1) | HUE044392T2 (enExample) |
| LT (1) | LT2996720T (enExample) |
| MX (2) | MX387527B (enExample) |
| NL (1) | NL1040254C2 (enExample) |
| PH (1) | PH12015502591B1 (enExample) |
| PL (2) | PL2996720T3 (enExample) |
| PT (2) | PT2996720T (enExample) |
| RS (1) | RS58857B1 (enExample) |
| RU (1) | RU2671977C2 (enExample) |
| SI (1) | SI2996720T1 (enExample) |
| SM (1) | SMT201900359T1 (enExample) |
| TR (1) | TR201908663T4 (enExample) |
| WO (1) | WO2014184352A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL1040254C2 (en) * | 2013-05-17 | 2014-11-24 | Ablynx Nv | Stable formulations of immunoglobulin single variable domains and uses thereof. |
| AU2015366284B2 (en) | 2014-12-19 | 2021-07-22 | Ablynx N.V. | Cysteine linked nanobody dimers |
| CN105833255A (zh) * | 2016-03-23 | 2016-08-10 | 兆科药业（合肥）有限公司 | 抗血小板溶栓素在制备治疗血栓性血小板减少性紫癜的药物中的应用 |
| GB201612043D0 (en) * | 2016-07-11 | 2016-08-24 | Crescendo Biologics Ltd | Composition for treatment of disorders |
| EP3534963B1 (en) * | 2016-11-02 | 2024-04-17 | Polaris Group | Formulations of pegylated arginine deiminase |
| MX2020008294A (es) | 2018-02-06 | 2020-11-18 | Ablynx Nv | Metodos de tratamiento de episodio inicial de ttp con dominios variables simples de inmunoglobulina. |
| BR112021000021A2 (pt) | 2018-07-03 | 2021-03-30 | Fennec Pharmaceuticals, Inc. | Tiossulfato de sódio anidro e formulações do mesmo |
| BR112021004126A2 (pt) * | 2018-09-05 | 2021-05-25 | Ventria Bioscience Inc. | formulação profilática e/ou terapêutica estabilizada e método profilático ou terapêutico |
| MX2021004146A (es) * | 2018-10-10 | 2021-06-08 | Astellas Pharma Inc | Composicion farmaceutica que contiene complejo de fragmento fab de anticuerpo antihumano con sitio marcado. |
| CN110564841A (zh) * | 2019-09-19 | 2019-12-13 | 广东省中医院（广州中医药大学第二附属医院、广州中医药大学第二临床医学院、广东省中医药科学院） | 脑缺血相关基因作为缺血性卒中行为学特征分析的生物标记的应用 |
| CN110624105B (zh) * | 2019-09-24 | 2021-06-11 | 苏州大学 | 血管性血友病因子的结构敏感多肽抗原的序列 |
| JP7502861B2 (ja) * | 2019-12-27 | 2024-06-19 | 旭化成株式会社 | 標的物質と両親媒性高分子との複合体の形成反応の反応温度の評価方法 |
| KR20230065258A (ko) * | 2020-09-09 | 2023-05-11 | 암젠 인크 | 동결건조된 약물 제품의 유통 기한 안정성의 예측 |
| US20240100158A1 (en) * | 2021-01-20 | 2024-03-28 | Dr. Reddy’S Laboratories Limited | Freeze dried antibody formulations and methods thereof |
| CN113908254B (zh) * | 2021-10-19 | 2024-05-28 | 山西锦波生物医药股份有限公司 | 一种干粉吸入剂及其制备方法和用途 |
| CN115850493B (zh) * | 2022-11-08 | 2024-03-12 | 江苏耀海生物制药有限公司 | 一种二价纳米抗体Cablivi的分离纯化方法 |
| WO2025240928A1 (en) * | 2024-05-16 | 2025-11-20 | Vega Therapeutics, Inc. | Treatment of von willebrand disease |
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| DE69334275D1 (de) | 1992-08-21 | 2009-05-20 | Univ Bruxelles | Immunoglobuline ohne Leichtkette |
| WO1994025591A1 (en) | 1993-04-29 | 1994-11-10 | Unilever N.V. | PRODUCTION OF ANTIBODIES OR (FUNCTIONALIZED) FRAGMENTS THEREOF DERIVED FROM HEAVY CHAIN IMMUNOGLOBULINS OF $i(CAMELIDAE) |
| FR2708622B1 (fr) | 1993-08-02 | 1997-04-18 | Raymond Hamers | Vecteur recombinant contenant une séquence d'un gène de lipoprotéine de structure pour l'expression de séquences de nucléotides. |
| AU696387B2 (en) | 1994-05-18 | 1998-09-10 | Inhale Therapeutic Systems, Inc. | Methods and compositions for the dry powder formulation of interferons |
| EP0739981A1 (en) | 1995-04-25 | 1996-10-30 | Vrije Universiteit Brussel | Variable fragments of immunoglobulins - use for therapeutic or veterinary purposes |
| ATE374248T1 (de) | 1996-06-27 | 2007-10-15 | Vlaams Interuniv Inst Biotech | Antikörpermoleküle, die spezifisch mit dem aktiven zentrum oder dem aktiven spalt eines zielmoleküls interagieren |
| US6329516B1 (en) | 1997-04-28 | 2001-12-11 | Fmc Corporation | Lepidopteran GABA-gated chloride channels |
| DK1027439T3 (da) | 1997-10-27 | 2010-05-10 | Bac Ip Bv | Multivalente antigenbindende proteiner |
| AU3596599A (en) | 1998-01-26 | 1999-08-09 | Unilever Plc | Method for producing antibody fragments |
| EP0967284A1 (en) | 1998-05-28 | 1999-12-29 | Pfizer Limited | Phosphodiesterases |
| BR9916765A (pt) | 1999-01-05 | 2001-09-25 | Unilever Nv | Processo para produzir um material imunoadsorvente, uso de uma proteìna que é ligada por meio de uma ligação covalente a um fragmento de anticorpo, material imunadsorvente, uso de um material, e, kit de teste diagnóstico |
| ATE276359T1 (de) | 1999-01-19 | 2004-10-15 | Unilever Nv | Verfahren zur herstellung von antikörperfragmenten |
| NZ513356A (en) | 1999-02-05 | 2004-01-30 | Univ Leiden | Method of modulating metabolite biosynthesis in recombinant cells using an AP2-domain transcription factor that is involved in the response of a plant cell to a jasmonate |
| WO2000055318A2 (en) | 1999-03-15 | 2000-09-21 | University Of British Columbia | Abc1 polypeptide and methods and reagents for modulating cholesterol levels |
| CN1252264C (zh) | 1999-04-22 | 2006-04-19 | 荷兰联合利华有限公司 | 利用单价抗原－结合蛋白抑制病毒感染 |
| EP1190065A2 (en) | 1999-06-18 | 2002-03-27 | Cv Therapeutics, Inc. | Atp binding cassette transporter protein abc1 polypeptides |
| WO2001009300A2 (en) | 1999-08-02 | 2001-02-08 | Keygene N.V. | Method for generating cgmmv resistant plants, genetic constructs, and obtained cgmmv-resistant plants |
| GB9922124D0 (en) | 1999-09-17 | 1999-11-17 | Pfizer Ltd | Phosphodiesterase enzymes |
| US6479280B1 (en) | 1999-09-24 | 2002-11-12 | Vlaams Interuniversitair Institutuut Voor Biotechnologie Vzw | Recombinant phages capable of entering host cells via specific interaction with an artificial receptor |
| DE19955408A1 (de) | 1999-11-18 | 2001-05-23 | Bayer Ag | GABA-B-Rezeptoren |
| ATE342922T1 (de) | 1999-11-29 | 2006-11-15 | Unilever Nv | Immobilisierung von proteinen mit hilfe eines polypeptidsegments |
| ATE440111T1 (de) | 1999-11-29 | 2009-09-15 | Bac Ip B V | Immobilisierte antigenbindende moleküle aus einer domäne |
| ATE428733T1 (de) | 2000-03-14 | 2009-05-15 | Unilever Nv | Variabele domänen der schweren kette eines antikörpers gegen menschliche ernährungslipasen und deren verwendungen |
| US20030190598A1 (en) | 2000-05-26 | 2003-10-09 | Jasmid Tanha | Single-domain antigen-binding antibody fragments derived from llama antibodies |
| AU2002229639A1 (en) | 2000-12-13 | 2002-06-24 | De Haard, Johannes Joseph Wilhelmus | Camelidae antibody arrays |
| AU2002319544B2 (en) | 2001-08-10 | 2008-07-10 | Aberdeen University | Antigen binding domains from fish |
| CA2459794C (en) | 2001-09-12 | 2012-08-21 | Virexx Medical Corp. | Vascular occlusion solid-phase agent with immobilised platelet binding agent |
| JP4213586B2 (ja) | 2001-09-13 | 2009-01-21 | 株式会社抗体研究所 | ラクダ抗体ライブラリーの作製方法 |
| US6723359B2 (en) | 2001-10-18 | 2004-04-20 | Firmenich Sa | Spray-dried compositions and method for their preparation |
| JP2005289809A (ja) | 2001-10-24 | 2005-10-20 | Vlaams Interuniversitair Inst Voor Biotechnologie Vzw (Vib Vzw) | 突然変異重鎖抗体 |
| EP1456410A2 (en) | 2001-12-11 | 2004-09-15 | AlgoNomics N.V. | Method for displaying loops from immunoglobulin domains in different contexts |
| JP4323317B2 (ja) | 2001-12-21 | 2009-09-02 | フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー（ヴェーイーベー・ヴェーゼットウェー） | 可変領域配列のクローニング方法 |
| WO2003055527A2 (en) | 2002-01-03 | 2003-07-10 | Vlaams Interuniversitair Instituut Voor Biotechnologie Vzw | Immunoconjugates useful for treatment of tumours |
| GB0202633D0 (en) * | 2002-02-05 | 2002-03-20 | Delta Biotechnology Ltd | Stabilization of protein preparations |
| ATE512364T1 (de) | 2002-08-07 | 2011-06-15 | Ablynx Nv | Modulation der blutplättchen-adhäsion basierend auf dem oberflächen-exponierten beta-switch loop des blutplättchen-glycoproteins ib-alpha |
| EP1565482B1 (en) | 2002-10-23 | 2014-04-30 | Ludwig Institute for Cancer Research Ltd. | A34 and a33-like 3 dna, proteins, antibodies thereto and methods of treatment using same |
| EP1558645B1 (en) | 2002-11-08 | 2011-07-27 | Ablynx N.V. | Stabilized single domain antibodies in pharmaceutical composition adapted for inhalation |
| NZ540194A (en) | 2002-11-08 | 2008-07-31 | Ablynx Nv | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| AU2004247737B2 (en) | 2003-06-11 | 2009-04-23 | Wyeth | Platelet glycoprotein IB alpha variant fusion polypeptides and methods of use thereof |
| PT1687338E (pt) | 2003-11-07 | 2011-01-20 | Ablynx Nv | Anticorpos de domínio único vhh de camelídeos direccionados para o receptor do factor de crescimento epidérmico e suas utilizações |
| WO2006040153A2 (en) | 2004-10-13 | 2006-04-20 | Ablynx N.V. | Single domain camelide anti -amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as alzheimer's disease |
| SI1836500T1 (sl) | 2005-01-14 | 2010-11-30 | Ablynx Nv | Postopki in testi za razlikovanje med različnimioblikami bolezni in motenj ki so označene s trombocitopenijo in ali s spontano interakcijo med von Willebrandovim faktorjem vWF in krvnimi ploščicami |
| JP2008528010A (ja) | 2005-01-31 | 2008-07-31 | アブリンクス ナームローゼ フェンノートシャップ | 重鎖抗体の可変ドメイン配列を作出する方法 |
| AU2006249144B2 (en) | 2005-05-18 | 2011-11-17 | Ablynx Nv | Improved NanobodiesTM against Tumor Necrosis Factor-alpha |
| LT2444424T (lt) | 2005-05-20 | 2018-10-25 | Ablynx N.V. | Pagerintos tm nanodalelės, skirtos agregacijos sąlygotų sutrikimų gydymui |
| JP5085322B2 (ja) * | 2005-06-10 | 2012-11-28 | 中外製薬株式会社 | ｓｃ（Ｆｖ）２を含有する医薬組成物 |
| WO2007104529A2 (en) | 2006-03-13 | 2007-09-20 | Ablynx N.V. | Amino acid sequences directed against il-6 and polypeptides comprising the same for the treatment of diseases and disorders associated with il-6-mediated signalling |
| JP2010511397A (ja) | 2006-12-05 | 2010-04-15 | アブリンクス エン．ヴェー． | 血清タンパク質と結合可能なペプチド |
| CA2681743A1 (en) * | 2007-03-22 | 2008-09-25 | Imclone Llc | Stable antibody formulations |
| EP2244814B1 (en) * | 2007-12-28 | 2021-06-02 | Takeda Pharmaceutical Company Limited | Recombinant vwf formulations |
| SG2013054218A (en) * | 2008-01-15 | 2014-10-30 | Abbott Gmbh & Co Kg | Powdered protein compositions and methods of making same |
| US20110158996A1 (en) * | 2008-03-21 | 2011-06-30 | Ablynx N.V. | Von willebrand factor specific binders and methods of use therefor |
| CA2721202A1 (en) | 2008-04-17 | 2009-10-22 | Hilde Adi Pierrette Revets | Peptides capable of binding to serum proteins and compounds, constructs and polypeptides comprising the same |
| EP2349314B1 (en) * | 2008-10-21 | 2013-02-27 | Baxter International Inc. | Lyophilized recombinant vwf formulations |
| RU2481824C2 (ru) | 2008-10-29 | 2013-05-20 | Аблинкс Н.В | Препараты однодоменных антигенсвязывающих молекул |
| EP2196476A1 (en) * | 2008-12-10 | 2010-06-16 | Novartis Ag | Antibody formulation |
| US20120321640A1 (en) | 2009-12-01 | 2012-12-20 | Ablynx N.V. | Von willebrand factor specific binding agents and uses thereof |
| EP2531523A1 (en) | 2010-02-05 | 2012-12-12 | Ablynx N.V. | Peptides capable of binding to serum albumin and compounds, constructs and polypeptides comprising the same |
| SI2533761T1 (sl) * | 2010-02-11 | 2019-08-30 | Ablynx N.V. | Postopki in sestavki za pripravo aerosolov |
| US20120225072A1 (en) * | 2011-03-02 | 2012-09-06 | Ablynx N.V. | Stable formulations of immunoglobulin single variable domains and uses thereof |
| CN104956600B (zh) | 2013-02-01 | 2018-09-25 | 飞利浦灯具控股公司 | 经由功率波形的通信 |
| NL1040254C2 (en) * | 2013-05-17 | 2014-11-24 | Ablynx Nv | Stable formulations of immunoglobulin single variable domains and uses thereof. |
-
2013
- 2013-06-14 NL NL1040254A patent/NL1040254C2/en active
-
2014
- 2014-05-16 SM SM20190359T patent/SMT201900359T1/it unknown
- 2014-05-16 PT PT14727433T patent/PT2996720T/pt unknown
- 2014-05-16 HR HRP20190954TT patent/HRP20190954T1/hr unknown
- 2014-05-16 WO PCT/EP2014/060107 patent/WO2014184352A1/en not_active Ceased
- 2014-05-16 HU HUE14727433 patent/HUE044392T2/hu unknown
- 2014-05-16 RU RU2015154214A patent/RU2671977C2/ru active
- 2014-05-16 SI SI201431229T patent/SI2996720T1/sl unknown
- 2014-05-16 TR TR2019/08663T patent/TR201908663T4/tr unknown
- 2014-05-16 EP EP14727433.6A patent/EP2996720B1/en active Active
- 2014-05-16 BR BR112015028411-6A patent/BR112015028411B1/pt active IP Right Grant
- 2014-05-16 PT PT191571470T patent/PT3511018T/pt unknown
- 2014-05-16 PL PL14727433T patent/PL2996720T3/pl unknown
- 2014-05-16 ES ES19157147T patent/ES2895150T3/es active Active
- 2014-05-16 KR KR1020157035523A patent/KR102166399B1/ko active Active
- 2014-05-16 LT LTEP14727433.6T patent/LT2996720T/lt unknown
- 2014-05-16 DK DK14727433.6T patent/DK2996720T3/da active
- 2014-05-16 CN CN201811423557.0A patent/CN110063935B/zh active Active
- 2014-05-16 ES ES14727433T patent/ES2731922T3/es active Active
- 2014-05-16 US US14/891,441 patent/US10035862B2/en active Active
- 2014-05-16 MX MX2019005269A patent/MX387527B/es unknown
- 2014-05-16 AU AU2014267222A patent/AU2014267222B2/en active Active
- 2014-05-16 MX MX2015015722A patent/MX364664B/es active IP Right Grant
- 2014-05-16 CN CN201811422890.XA patent/CN110037983A/zh active Pending
- 2014-05-16 EP EP19157147.0A patent/EP3511018B1/en active Active
- 2014-05-16 CN CN201480034630.9A patent/CN105339003B/zh active Active
- 2014-05-16 JP JP2016513387A patent/JP6433986B2/ja active Active
- 2014-05-16 CA CA2912670A patent/CA2912670A1/en not_active Abandoned
- 2014-05-16 RS RS20190694A patent/RS58857B1/sr unknown
- 2014-05-16 PL PL19157147T patent/PL3511018T3/pl unknown
-
2015
- 2015-11-16 PH PH12015502591A patent/PH12015502591B1/en unknown
-
2018
- 2018-06-14 US US16/008,103 patent/US12662550B2/en active Active
- 2018-11-07 JP JP2018209611A patent/JP6952019B2/ja active Active
-
2019
- 2019-02-25 AU AU2019201307A patent/AU2019201307B2/en active Active
- 2019-06-26 CY CY20191100669T patent/CY1122090T1/el unknown
-
2021
- 2021-01-05 AU AU2021200035A patent/AU2021200035A1/en not_active Abandoned
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