KR890004724A - 신규 프로테아제 제제(製劑) - Google Patents

신규 프로테아제 제제(製劑) Download PDF

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Publication number
KR890004724A
KR890004724A KR870010309A KR870010309A KR890004724A KR 890004724 A KR890004724 A KR 890004724A KR 870010309 A KR870010309 A KR 870010309A KR 870010309 A KR870010309 A KR 870010309A KR 890004724 A KR890004724 A KR 890004724A
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South Korea
Prior art keywords
treated
minutes
activity
remaining
inhibited
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Application number
KR870010309A
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English (en)
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히사시 미하라
히로유끼 스미
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히사시 미하라
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Application filed by 히사시 미하라 filed Critical 히사시 미하라
Priority to KR870010309A priority Critical patent/KR890004724A/ko
Priority to JP63210670A priority patent/JP2716472B2/ja
Publication of KR890004724A publication Critical patent/KR890004724A/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

내용 없음

Description

신규 프로테아제 제제(製劑)
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음
제1도는 본 발명의 프로테아제 제제(製劑)의 pH와 잔존 활성과의 관계를 나타낸 그래프.
제2도는 온도와 잔존 활성과의 관계를 나타낸 그래프.

Claims (1)

  1. 하기의 효소 화학적 성질을 가진 지렁이 추출물 프랙션으로부터 이루어진 프로테아제 제제. (a) 작용 및 기질 특이성 : 피브린을 용해하거나, 피브리노겐을 용해하지 않고, 플라즈미노겐을 활성화 해서 플라즈민을 생성하고, 또한 우로키나아제 및 플라즈민의 합성 기질인 4-메틸-쿠마릴 아미드의 펩타이드 유도체에 대해서 작용한다. (b) 최적 pH:pH 8.0∼10.0, (c) 최적 온도:45℃∼55℃, (d) 안정 pH:pH 3.5∼10, (e) 열안정성:50℃에서 60분간 처리하였을 때의 잔존 활성이 100%, 60℃에서 60분간 처리하였을 때의 잔존활성이 75%, 70℃에서 60분간 처리하였을 때의 잔존활성이 25%이다. (f) 등전점:pH3.7∼4.0, (g) 분자량 : 약 25,000∼32,000, (h) 저해제:트라지롤(상품명), 대두 트립신 인히비타, 트랜사민(상품명) 및 사람 혈장에 의해서 저해되나, 트랜스-4-아미노 메틸시클로헥산 카르복실산에 의해서는 저해받지 않는다.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR870010309A 1987-09-17 1987-09-17 신규 프로테아제 제제(製劑) KR890004724A (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR870010309A KR890004724A (ko) 1987-09-17 1987-09-17 신규 프로테아제 제제(製劑)
JP63210670A JP2716472B2 (ja) 1987-09-17 1988-08-26 新規なプロテアーゼ製剤

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR870010309A KR890004724A (ko) 1987-09-17 1987-09-17 신규 프로테아제 제제(製劑)

Publications (1)

Publication Number Publication Date
KR890004724A true KR890004724A (ko) 1989-05-09

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ID=19264546

Family Applications (1)

Application Number Title Priority Date Filing Date
KR870010309A KR890004724A (ko) 1987-09-17 1987-09-17 신규 프로테아제 제제(製劑)

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JP (1) JP2716472B2 (ko)
KR (1) KR890004724A (ko)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE365052T1 (de) * 1999-02-22 2007-07-15 Univ Connecticut Neue albuminfreie faktor viii formulierungen
JP4501209B2 (ja) 2000-03-08 2010-07-14 ソニー株式会社 情報処理装置、情報処理方法およびリモコンのコマンダ
CN100406470C (zh) * 2001-03-30 2008-07-30 科学和工业研究委员会 从一种印度蚯蚓体腔液中得到的引起精子不能游动的蛋白
WO2006101140A1 (ja) * 2005-03-22 2006-09-28 Sodx Co., Ltd. 新規プロテアーゼ、該プロテアーゼを生産する微生物、及びこれらの利用
ATE475425T1 (de) 2008-03-26 2010-08-15 Well Stone Co Verfahren zur herstellung eines trockenen regenwurmpulvers
NZ593190A (en) 2008-11-07 2013-01-25 Baxter Int Factor viii formulations
CN101584853B (zh) * 2009-06-15 2012-12-19 南京中医药大学 一种地龙蛋白多肽制剂
CN103263660B (zh) * 2013-05-13 2015-05-20 肖梅芬 降糖、降压、消除糖尿病并发症的地龙蛋白及其应用
CN103239706B (zh) * 2013-05-13 2014-11-26 肖梅芬 降糖、改善微循环消除糖尿病并发症的地龙蛋白及其应用
CN103845273B (zh) * 2014-03-14 2017-06-30 江苏隆力奇生物科技股份有限公司 一种抗皮肤老化的地龙肽及其制备方法和应用
JP2016086736A (ja) * 2014-11-05 2016-05-23 日立化成株式会社 血中希少細胞含有液の製造方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5963184A (ja) * 1982-10-02 1984-04-10 Amano Pharmaceut Co Ltd 新規なプロテア−ゼ
JPH0694420B2 (ja) * 1983-03-31 1994-11-24 恒 美原 血栓溶解剤

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Publication number Publication date
JP2716472B2 (ja) 1998-02-18
JPS6475431A (en) 1989-03-22

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