ATE309264T1 - Peptidyl-2-amino-1hydroxyalkansulfonsäuren als cystein-protease-inhibitoren - Google Patents

Peptidyl-2-amino-1hydroxyalkansulfonsäuren als cystein-protease-inhibitoren

Info

Publication number
ATE309264T1
ATE309264T1 AT98915572T AT98915572T ATE309264T1 AT E309264 T1 ATE309264 T1 AT E309264T1 AT 98915572 T AT98915572 T AT 98915572T AT 98915572 T AT98915572 T AT 98915572T AT E309264 T1 ATE309264 T1 AT E309264T1
Authority
AT
Austria
Prior art keywords
amino
peptidyl
protease inhibitors
acids
cysteine protease
Prior art date
Application number
AT98915572T
Other languages
English (en)
Inventor
Ron Bihovsky
Ming Tao
Original Assignee
Cephalon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cephalon Inc filed Critical Cephalon Inc
Application granted granted Critical
Publication of ATE309264T1 publication Critical patent/ATE309264T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/022—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -X-C(=O)-(C)n-N-C-C(=O)-Y-; X and Y being heteroatoms; n being 1 or 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT98915572T 1997-04-18 1998-04-15 Peptidyl-2-amino-1hydroxyalkansulfonsäuren als cystein-protease-inhibitoren ATE309264T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US4467697P 1997-04-18 1997-04-18
US09/060,491 US6348448B1 (en) 1997-04-18 1998-04-15 Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors
PCT/US1998/007499 WO1998047523A1 (en) 1997-04-18 1998-04-15 Peptidyl-2-amino-1-hydroxyalkanesulfonic acid cysteine protease inhibitors

Publications (1)

Publication Number Publication Date
ATE309264T1 true ATE309264T1 (de) 2005-11-15

Family

ID=26721855

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98915572T ATE309264T1 (de) 1997-04-18 1998-04-15 Peptidyl-2-amino-1hydroxyalkansulfonsäuren als cystein-protease-inhibitoren

Country Status (10)

Country Link
US (2) US6348448B1 (de)
EP (1) EP0975353B1 (de)
JP (1) JP4144811B2 (de)
AT (1) ATE309264T1 (de)
AU (1) AU733420B2 (de)
CA (1) CA2286722C (de)
DE (1) DE69832268T2 (de)
ES (1) ES2252831T3 (de)
NZ (1) NZ500045A (de)
WO (1) WO1998047523A1 (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645939B1 (en) 1997-11-24 2003-11-11 Merck & Co., Inc. Substituted β-alanine derivatives as cell adhesion inhibitors
AU751950B2 (en) * 1997-11-24 2002-09-05 Merck & Co., Inc. Substituted beta-alanine derivatives as cell adhesion inhibitors
US6900237B2 (en) 2001-09-14 2005-05-31 Axys Pharmaceuticals, Inc. Sulfonamide compounds as protease inhibitors
WO2012174552A2 (en) * 2011-06-17 2012-12-20 Virobay, Inc. Cathepsin inhibitors for treating microglia-mediated neuron loss in the central nervous system
CN103649289A (zh) 2011-07-01 2014-03-19 诺维信公司 液体洗涤剂组合物
CN107858217B (zh) * 2011-07-01 2021-03-23 诺维信公司 稳定化的枯草杆菌蛋白酶组合物
WO2014152674A1 (en) 2013-03-14 2014-09-25 Novozymes A/S Enzyme and inhibitor containing water-soluble films
EP3461881B1 (de) 2013-05-03 2024-10-09 Novozymes A/S Mikroverkapselung von wasch- und reinigungsmittelenzymen
WO2016001319A1 (en) 2014-07-03 2016-01-07 Novozymes A/S Improved stabilization of non-protease enzyme
EP3234093B1 (de) 2014-12-19 2020-05-27 Novozymes A/S Proteasevarianten und dafür codierende polynukleotide
CN107969136B (zh) 2015-07-06 2021-12-21 诺维信公司 脂肪酶变体以及编码它们的多核苷酸
US11078445B2 (en) 2017-05-05 2021-08-03 Novozymes A/S Compositions comprising lipase and sulfite
EP3645692B1 (de) 2017-06-30 2025-12-31 Novozymes A/S Enzymschlammzusammensetzung
CN111527190A (zh) 2017-11-01 2020-08-11 诺维信公司 多肽以及包含此类多肽的组合物
EP3704240A1 (de) 2017-11-01 2020-09-09 Novozymes A/S Polypeptide und zusammensetzungen mit solchen polypeptiden
US20210002588A1 (en) 2018-03-13 2021-01-07 Novozymes A/S Microencapsulation Using Amino Sugar Oligomers
EP3647397A1 (de) 2018-10-31 2020-05-06 Henkel AG & Co. KGaA Reinigungsmittel mit dispersins iv
ES2981999T3 (es) 2018-10-31 2024-10-14 Henkel Ag & Co Kgaa Composiciones limpiadoras que contienen dispersinas V
EP3994148A1 (de) 2019-07-01 2022-05-11 Basf Se Peptideacetale zur stabilisierung von enzymen
WO2021123307A2 (en) 2019-12-20 2021-06-24 Novozymes A/S Polypeptides having proteolytic activity and use thereof
EP4305146A1 (de) 2021-03-12 2024-01-17 Novozymes A/S Polypeptidvarianten
WO2024131880A2 (en) 2022-12-23 2024-06-27 Novozymes A/S Detergent composition comprising catalase and amylase

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0124317B1 (de) 1983-04-27 1990-04-11 Ici Americas Inc. Prolin-Derivate
JPH075634B2 (ja) * 1987-10-30 1995-01-25 日東紡績株式会社 トリペプチド類及びこれを含有する抗プラスミン剤
DE4101895C1 (de) * 1991-01-23 1991-12-05 Forschungszentrum Juelich Gmbh, 5170 Juelich, De
US5436229A (en) 1994-03-04 1995-07-25 Eli Lilly And Company Bisulfite adducts of arginine aldehydes
PT861233E (pt) * 1995-11-16 2000-09-29 Searle & Co Beta-amino-hidroxissulfonatos n-protegidos/n-substituidos

Also Published As

Publication number Publication date
EP0975353B1 (de) 2005-11-09
JP4144811B2 (ja) 2008-09-03
NZ500045A (en) 2001-02-23
HK1025511A1 (en) 2000-11-17
ES2252831T3 (es) 2006-05-16
CA2286722A1 (en) 1998-10-29
AU6972098A (en) 1998-11-13
EP0975353A4 (de) 2001-11-28
WO1998047523A1 (en) 1998-10-29
JP2001520674A (ja) 2001-10-30
US6348448B1 (en) 2002-02-19
DE69832268D1 (en) 2005-12-15
EP0975353A1 (de) 2000-02-02
DE69832268T2 (de) 2006-07-13
CA2286722C (en) 2010-10-19
US6500802B1 (en) 2002-12-31
AU733420B2 (en) 2001-05-17

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