MY113489A - Reversible protease inhibitors - Google Patents
Reversible protease inhibitorsInfo
- Publication number
- MY113489A MY113489A MYPI96001076A MYPI19961076A MY113489A MY 113489 A MY113489 A MY 113489A MY PI96001076 A MYPI96001076 A MY PI96001076A MY PI19961076 A MYPI19961076 A MY PI19961076A MY 113489 A MY113489 A MY 113489A
- Authority
- MY
- Malaysia
- Prior art keywords
- protease inhibitors
- reversible protease
- reversible
- inhibitors
- specific
- Prior art date
Links
- 230000002441 reversible effect Effects 0.000 title abstract 2
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 title 1
- 239000000137 peptide hydrolase inhibitor Substances 0.000 title 1
- 102000005927 Cysteine Proteases Human genes 0.000 abstract 1
- 108010005843 Cysteine Proteases Proteins 0.000 abstract 1
- 108091005804 Peptidases Proteins 0.000 abstract 1
- 239000004365 Protease Substances 0.000 abstract 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
- C07D295/215—Radicals derived from nitrogen analogues of carbonic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C317/28—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
- C07F9/6533—Six-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Enzymes And Modification Thereof (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
THE INVENTION RELATES TO NOVEL REVERSIBLE PROTEASE. THE INHIBITORS ARE SPECIFIC TO CYSTEINE PROTEASES.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40999695A | 1995-03-24 | 1995-03-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MY113489A true MY113489A (en) | 2002-03-30 |
Family
ID=23622800
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MYPI96001076A MY113489A (en) | 1995-03-24 | 1996-03-22 | Reversible protease inhibitors |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0817778A1 (en) |
| JP (1) | JPH11503417A (en) |
| KR (1) | KR19980703261A (en) |
| CN (1) | CN1071751C (en) |
| AU (1) | AU713492B2 (en) |
| CA (1) | CA2216151A1 (en) |
| CZ (1) | CZ298197A3 (en) |
| IL (1) | IL117638A0 (en) |
| MY (1) | MY113489A (en) |
| NO (1) | NO311573B1 (en) |
| NZ (1) | NZ305626A (en) |
| PL (1) | PL322409A1 (en) |
| TW (1) | TW470750B (en) |
| WO (1) | WO1996030353A1 (en) |
| ZA (1) | ZA962336B (en) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6608030B1 (en) | 1996-04-22 | 2003-08-19 | Brigham & Women's Hospital, Inc. | Suppression of immune response via inhibition of cathepsin S |
| NZ333713A (en) * | 1996-07-30 | 2000-12-22 | Axys Pharm Inc | Compounds for treating diseases associated with tryptase activity |
| DE19817461A1 (en) | 1998-04-20 | 1999-10-21 | Basf Ag | New benzamide derivatives useful as cysteine protease inhibitors for treating neurodegenerative diseases, neuronal damage, stroke, cranial trauma, Alzheimer's disease, etc. |
| WO2000051998A1 (en) | 1999-03-02 | 2000-09-08 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compounds useful as reversible inhibitors of cathepsin s |
| US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
| ES2199856T3 (en) * | 1999-09-13 | 2004-03-01 | Boehringer Ingelheim Pharmaceuticals, Inc. | NEW HETEROCICLIC COMPOUNDS, USEFUL AS REVERSIBLE INHIBITORS OF CISTEINA PROTEASAS. |
| KR20020056923A (en) | 1999-11-18 | 2002-07-10 | 코르바스 인터내셔날, 인코포레이티드 | Nucleic acids encoding endotheliases, endotheliases and uses thereof |
| US7700341B2 (en) | 2000-02-03 | 2010-04-20 | Dendreon Corporation | Nucleic acid molecules encoding transmembrane serine proteases, the encoded proteins and methods based thereon |
| US7589202B2 (en) | 2000-08-14 | 2009-09-15 | Ortho Mcneil Pharmaceutical, Inc. | Substituted pyrazoles |
| US7332494B2 (en) | 2000-08-14 | 2008-02-19 | Janssen Pharmaceutica, N.V. | Method for treating allergies using substituted pyrazoles |
| JP4911864B2 (en) | 2000-08-14 | 2012-04-04 | オーソ−マクニール・フアーマシユーチカル・インコーポレーテツド | Substituted pyrazoles |
| DE60118004T2 (en) | 2000-08-14 | 2006-11-16 | Ortho-Mcneil Pharmaceutical, Inc. | SUBSTITUTED PYRAZOLE |
| RU2003106192A (en) | 2000-09-06 | 2004-07-27 | Орто-Макнейл Фармасьютикал, Инк. (Us) | METHOD FOR TREATING ALLERGIES |
| WO2002048097A1 (en) * | 2000-12-12 | 2002-06-20 | Corvas International, Inc. | Compounds, compositions and methods for treatment of parasitic infections |
| US7030116B2 (en) | 2000-12-22 | 2006-04-18 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
| US7064123B1 (en) | 2000-12-22 | 2006-06-20 | Aventis Pharmaceuticals Inc. | Compounds and compositions as cathepsin inhibitors |
| WO2003024923A1 (en) * | 2001-09-14 | 2003-03-27 | Axys Pharmaceuticals, Inc. | Sulfonamide compounds as protease inhibitors |
| IL160819A0 (en) * | 2001-09-14 | 2004-08-31 | Aventis Pharma Inc | Novel compounds and compositions as cathepsin inhibitors |
| CN1324018C (en) | 2001-11-14 | 2007-07-04 | 安万特药物公司 | Oligopeptides and compositions containing them as cathepsin S inhibitors |
| GB0311406D0 (en) * | 2003-05-17 | 2003-06-25 | Queen Mary & Westfield College | Substituted phosphonate fluorescent sensors,and use thereof |
| ES2640814T3 (en) | 2008-05-21 | 2017-11-06 | Genesis Technologies Limited | Selective caspase inhibitors and their uses |
| US9045524B2 (en) | 2009-05-21 | 2015-06-02 | Novagenesis Foundation | Selective caspase inhibitors and uses thereof |
| WO2011069149A2 (en) | 2009-12-04 | 2011-06-09 | Dcb-Usa Llc | Cathepsin s inhibitors |
| ES2665301T3 (en) | 2011-04-15 | 2018-04-25 | Genesis Technologies Limited | Selective cysteine prorease inhibitors and their uses |
| KR101309578B1 (en) * | 2011-05-06 | 2013-09-17 | 연세대학교 산학협력단 | Dityrosine compounds having selectivity for cysteine proteases and method for monitoring cysteine proteases using the same |
| KR101385855B1 (en) * | 2012-10-16 | 2014-04-22 | 이동익 | Diaromatic amino acid-based substrate for detecting cathepsins |
| WO2019142890A1 (en) * | 2018-01-19 | 2019-07-25 | 株式会社大阪ソーダ | Organosilicon compound and rubber composition including same |
| EP3553521A1 (en) * | 2018-04-12 | 2019-10-16 | Koninklijke Philips N.V. | Gingivitis diagnostic methods, uses and kits |
-
1996
- 1996-03-21 PL PL96322409A patent/PL322409A1/en unknown
- 1996-03-21 NZ NZ305626A patent/NZ305626A/en unknown
- 1996-03-21 KR KR1019970706665A patent/KR19980703261A/en not_active Application Discontinuation
- 1996-03-21 CZ CZ972981A patent/CZ298197A3/en unknown
- 1996-03-21 JP JP8529509A patent/JPH11503417A/en active Pending
- 1996-03-21 AU AU53674/96A patent/AU713492B2/en not_active Ceased
- 1996-03-21 WO PCT/US1996/003844 patent/WO1996030353A1/en not_active Application Discontinuation
- 1996-03-21 CA CA002216151A patent/CA2216151A1/en not_active Abandoned
- 1996-03-21 CN CN96193951A patent/CN1071751C/en not_active Expired - Fee Related
- 1996-03-21 EP EP96910499A patent/EP0817778A1/en not_active Withdrawn
- 1996-03-22 ZA ZA962336A patent/ZA962336B/en unknown
- 1996-03-22 MY MYPI96001076A patent/MY113489A/en unknown
- 1996-03-24 IL IL11763896A patent/IL117638A0/en unknown
- 1996-04-12 TW TW085104392A patent/TW470750B/en active
-
1997
- 1997-09-23 NO NO19974403A patent/NO311573B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA962336B (en) | 1996-07-31 |
| AU5367496A (en) | 1996-10-16 |
| CA2216151A1 (en) | 1996-10-03 |
| KR19980703261A (en) | 1998-10-15 |
| CN1184472A (en) | 1998-06-10 |
| CZ298197A3 (en) | 1998-03-18 |
| TW470750B (en) | 2002-01-01 |
| WO1996030353A1 (en) | 1996-10-03 |
| JPH11503417A (en) | 1999-03-26 |
| NO974403D0 (en) | 1997-09-23 |
| NZ305626A (en) | 2000-01-28 |
| NO974403L (en) | 1997-11-17 |
| PL322409A1 (en) | 1998-01-19 |
| NO311573B1 (en) | 2001-12-10 |
| IL117638A0 (en) | 1996-07-23 |
| CN1071751C (en) | 2001-09-26 |
| EP0817778A1 (en) | 1998-01-14 |
| AU713492B2 (en) | 1999-12-02 |
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