DE3587526D1 - Serinproteaseinhibitoren und isolierungsverfahren dazu. - Google Patents

Serinproteaseinhibitoren und isolierungsverfahren dazu.

Info

Publication number
DE3587526D1
DE3587526D1 DE8686900423T DE3587526T DE3587526D1 DE 3587526 D1 DE3587526 D1 DE 3587526D1 DE 8686900423 T DE8686900423 T DE 8686900423T DE 3587526 T DE3587526 T DE 3587526T DE 3587526 D1 DE3587526 D1 DE 3587526D1
Authority
DE
Germany
Prior art keywords
serine protease
protease inhibitor
inhibitor
ability
inhibit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE8686900423T
Other languages
English (en)
Other versions
DE3587526T2 (de
DE3587526T3 (de
Inventor
Robert Thompson
Kjell Ohlsson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amgen Inc
Original Assignee
Synergen Biologicals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27102098&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE3587526(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Synergen Biologicals Inc filed Critical Synergen Biologicals Inc
Application granted granted Critical
Publication of DE3587526D1 publication Critical patent/DE3587526D1/de
Publication of DE3587526T2 publication Critical patent/DE3587526T2/de
Publication of DE3587526T3 publication Critical patent/DE3587526T3/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/81—Protease inhibitors
    • C07K14/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
    • C07K14/811—Serine protease (E.C. 3.4.21) inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Detergent Compositions (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
DE3587526T 1984-12-06 1985-12-04 Serinproteaseinhibitoren und isolierungsverfahren dazu. Expired - Lifetime DE3587526T3 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US67882384A 1984-12-06 1984-12-06
US80347185A 1985-12-02 1985-12-02
PCT/US1985/002384 WO1986003497A1 (en) 1984-12-06 1985-12-04 Serine protease inhibitors and methods for isolation of same

Publications (3)

Publication Number Publication Date
DE3587526D1 true DE3587526D1 (de) 1993-09-16
DE3587526T2 DE3587526T2 (de) 1993-11-25
DE3587526T3 DE3587526T3 (de) 2002-08-08

Family

ID=27102098

Family Applications (1)

Application Number Title Priority Date Filing Date
DE3587526T Expired - Lifetime DE3587526T3 (de) 1984-12-06 1985-12-04 Serinproteaseinhibitoren und isolierungsverfahren dazu.

Country Status (5)

Country Link
EP (1) EP0205555B2 (de)
AT (1) ATE92935T1 (de)
AU (1) AU591474B2 (de)
DE (1) DE3587526T3 (de)
WO (1) WO1986003497A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6291662B1 (en) 1984-12-05 2001-09-18 Amgen Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences
US5871956A (en) * 1984-12-06 1999-02-16 Amgen Inc. Recombinant methods for production of serine inhibitors and DNA sequences useful for same
US5900400A (en) * 1984-12-06 1999-05-04 Amgen Inc. Serine protease inhibitor analogs
US6132990A (en) * 1984-12-06 2000-10-17 Amgen Boulder Inc. Recombinant methods for production of serine protease inhibitors and DNA sequences useful for same
DE3600571A1 (de) * 1986-01-10 1987-08-06 Gruenenthal Gmbh Dna-sequenzen, die fuer proteine mit der biologischen aktivitaet der husi-typi-inhibitoren codieren, gentechnologische verfahren zur herstellung dieser proteine und diese proteine enthaltende arzneimittel
EP0238473A3 (de) * 1986-03-18 1989-06-07 Monsanto Company Serinprotease-Hemmungsstoffe
DE3841873A1 (de) * 1988-12-13 1990-06-21 Gruenenthal Gmbh Neue serinprotease-inhibitor-proteine, diese enthaltende arzneimittel, dna-sequenzen, die fuer diese proteine codieren und verfahren zur herstellung dieser proteine, arzneimittel und dna-sequenzen
JPH0739329B2 (ja) * 1989-03-13 1995-05-01 味の素株式会社 植物の開花を制御する方法及び植物の開花制御剤
FR2647677B1 (fr) * 1989-05-31 1991-09-27 Roussel Uclaf Nouvelles micro-proteines, procede de preparation et application a titre de medicaments de ces nouvelles micro-proteines
DK0547102T3 (da) * 1990-09-05 1999-04-19 Natinco Nv Opløseliggørelse af proteiner på aktiv form
US6869925B1 (en) * 1992-09-09 2005-03-22 Amgen Inc. Inhibition of retrovirus infection
US6017880A (en) * 1994-03-09 2000-01-25 Amgen Inc. Inhibition of retrovirus infection
KR970701561A (ko) * 1994-03-23 1997-04-12 아사이 이뻬이 신규 기도부 바이러스 질환 치료제(Novel Remedy for Respiratory-Tract Viral Disease)
US5633227A (en) * 1994-09-12 1997-05-27 Miles, Inc. Secretory leukocyte protease inhibitor as an inhibitor of tryptase
EP0834556A1 (de) * 1996-09-25 1998-04-08 Academisch Ziekenhuis Leiden Verfahren zur Zellkultivierung

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE668563A (de) * 1964-09-22 1965-12-16
AU577259B2 (en) * 1982-08-13 1988-09-22 Zymogenetics Inc. Glycolytic promters for regulated protein expression protease inhibitor
AU560584B2 (en) * 1983-07-28 1987-04-09 Bayer Aktiengesellschaft Homologues of aprotinin
JPS60186290A (ja) * 1983-08-10 1985-09-21 チモ−ジエネテイツクス　インコ−ポレ−テツド アルフア−１−アンチトリプシンを細菌に表現させる方法
US4711848A (en) * 1984-03-14 1987-12-08 Zymogenetics, Inc. Site specific mutagenesis in alpha-1-antitrypsin
WO1986003519A1 (en) * 1984-12-06 1986-06-19 Synergen Biologicals, Inc. Recombinant methods for production of serine protease inhibitors and dna sequences useful for same

Also Published As

Publication number Publication date
EP0205555A4 (de) 1987-11-09
AU591474B2 (en) 1989-12-07
AU5232886A (en) 1986-07-01
WO1986003497A1 (en) 1986-06-19
DE3587526T2 (de) 1993-11-25
DE3587526T3 (de) 2002-08-08
EP0205555A1 (de) 1986-12-30
ATE92935T1 (de) 1993-08-15
EP0205555B1 (de) 1993-08-11
EP0205555B2 (de) 2002-04-10

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8327 Change in the person/name/address of the patent owner

Owner name: AMGEN BOULDER INC. (N.D.GES.D. STAATES DELAWARE),

8327 Change in the person/name/address of the patent owner

Owner name: AMGEN INC.(N.D.GES D. STAATES DELAWARE), THOUSAND

8366 Restricted maintained after opposition proceedings