IT1248723B - Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo - Google Patents

Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo

Info

Publication number
IT1248723B
IT1248723B IT02061090A IT2061090A IT1248723B IT 1248723 B IT1248723 B IT 1248723B IT 02061090 A IT02061090 A IT 02061090A IT 2061090 A IT2061090 A IT 2061090A IT 1248723 B IT1248723 B IT 1248723B
Authority
IT
Italy
Prior art keywords
factor viii
purification
viii obtained
factor
viii
Prior art date
Application number
IT02061090A
Other languages
English (en)
Other versions
IT9020610A1 (it
IT9020610A0 (it
Inventor
Silvana Arrighi
Maria Giuseppina Borri
Costante Ceccarini
Original Assignee
Scalvo S P A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scalvo S P A filed Critical Scalvo S P A
Priority to IT02061090A priority Critical patent/IT1248723B/it
Publication of IT9020610A0 publication Critical patent/IT9020610A0/it
Priority to EP19910109496 priority patent/EP0468181A3/en
Priority to CA002044191A priority patent/CA2044191A1/en
Priority to US07/713,071 priority patent/US5259951A/en
Priority to JP3166197A priority patent/JPH04243899A/ja
Publication of IT9020610A1 publication Critical patent/IT9020610A1/it
Application granted granted Critical
Publication of IT1248723B publication Critical patent/IT1248723B/it

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2525—Stabilizing or preserving
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
IT02061090A 1990-06-12 1990-06-12 Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo IT1248723B (it)

Priority Applications (5)

Application Number Priority Date Filing Date Title
IT02061090A IT1248723B (it) 1990-06-12 1990-06-12 Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo
EP19910109496 EP0468181A3 (en) 1990-06-12 1991-06-10 Process for the purification of factor viii and factor viii obtained by said process
CA002044191A CA2044191A1 (en) 1990-06-12 1991-06-10 Process for the purification of factor viii and factor viii obtained by said process
US07/713,071 US5259951A (en) 1990-06-12 1991-06-11 Process for the purification of factor VIII and factor VIII obtained by said process
JP3166197A JPH04243899A (ja) 1990-06-12 1991-06-12 第ｖｉｉｉ因子の精製およびこの方法で得られた第ｖｉｉｉ因子

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT02061090A IT1248723B (it) 1990-06-12 1990-06-12 Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo

Publications (3)

Publication Number Publication Date
IT9020610A0 IT9020610A0 (it) 1990-06-12
IT9020610A1 IT9020610A1 (it) 1991-12-12
IT1248723B true IT1248723B (it) 1995-01-26

Family

ID=11169516

Family Applications (1)

Application Number Title Priority Date Filing Date
IT02061090A IT1248723B (it) 1990-06-12 1990-06-12 Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo

Country Status (5)

Country Link
US (1) US5259951A (it)
EP (1) EP0468181A3 (it)
JP (1) JPH04243899A (it)
CA (1) CA2044191A1 (it)
IT (1) IT1248723B (it)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5760183A (en) * 1989-02-17 1998-06-02 Association D'aquitaine Pour De Developpment De La Transfusion Sanguine Et Des Recherches Hematologiques Process for the manufacture of very high-purity antithaemophilic factor (FVIIIC), and von Willebrand factor, and pharmaceutical compositions containing same
US5629287A (en) * 1991-01-18 1997-05-13 University College London Depot formulations
US5610148A (en) * 1991-01-18 1997-03-11 University College London Macroscopically oriented cell adhesion protein for wound treatment
DE4111393A1 (de) * 1991-04-09 1992-10-15 Behringwerke Ag Stabilisierte faktor viii-praeparationen
FR2686883B1 (fr) * 1992-02-04 1994-05-13 Aquitaine Develop Transf Sanguin Procede de fabrication de fibrinogene de tres haute purete, fibrinogene de tres haute purete obtenu ainsi qu'une composition pharmaceutique le contenant.
US5288853A (en) * 1992-04-30 1994-02-22 Alpha Therapeutic Corporation Factor viii purification process
IT1256622B (it) * 1992-12-04 1995-12-12 Sclavo Spa Processo per l'estrazione del complesso fattore viii-fattore von willebrand (fviii:c-fvw) da plasma umano totale.
AU2201295A (en) * 1994-04-08 1995-10-30 Amicon, Inc. Method and apparatus for isolation and purification of biologically active complexes
SE9403915D0 (sv) * 1994-11-14 1994-11-14 Annelie Almstedt Process A
US5833860A (en) * 1995-08-28 1998-11-10 Millipore Investment Holdings Limited Centrifugal adsorptive sample preparation device and method
US5659017A (en) * 1995-11-07 1997-08-19 Alpha Therapeutic Corporation Anion exchange process for the purification of Factor VIII
US6320029B1 (en) 1996-11-29 2001-11-20 The American National Red Cross Methods of production and use of liquid formulations of plasma proteins
US5925738A (en) * 1995-12-01 1999-07-20 The American National Red Cross Methods of production and use of liquid formulations of plasma proteins
USRE38431E1 (en) * 1995-12-01 2004-02-17 The American National Red Cross Methods of production and use of liquid formulations of plasma proteins
US6057164A (en) * 1996-03-08 2000-05-02 Octapharma Ag Process for testing suitability of protein fractions containing factor VIII
FR2772381B1 (fr) * 1997-12-15 2001-06-08 Lab Francais Du Fractionnement Procede de preparation par filtration d'une solution de facteur viii securisee viralement
WO2000048635A1 (en) 1999-02-22 2000-08-24 Baxter International Inc. Novel albumin-free factor viii formulations
JP2001335509A (ja) * 2000-05-31 2001-12-04 Nihon Pharmaceutical Co Ltd フィブリノーゲンを含有する溶液のウイルス除去法
SI1596887T1 (sl) * 2003-02-26 2022-05-31 Nektar Therapeutics Konjugati polimer-del faktorja VIII
RU2253475C1 (ru) * 2004-02-02 2005-06-10 Общество с ограниченной ответственностью "Гемоцентр" Способ получения препарата фактора viii
US8920849B1 (en) 2006-03-30 2014-12-30 Kenneth P. Callison Skin treatment method and system
RU2326689C1 (ru) * 2007-03-13 2008-06-20 Общество с ограниченной ответственностью "БиоГениус" Способ получения концентрата viii фактора свертывания крови человека и продукт его содержащий
JP5069661B2 (ja) * 2008-10-22 2012-11-07 ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー ヒト血液凝固第ｘｉｉｉ因子の安定化された水性液製剤
ES2706296T3 (es) 2008-11-07 2019-03-28 Univ Connecticut Formulaciones de Factor VIII
US20160130361A1 (en) * 2013-06-13 2016-05-12 Biogen Ma Inc. Anti-factor viii antibodies or uses thereof
GB201906595D0 (en) * 2019-05-10 2019-06-26 Ge Healthcare Bioprocess R&D Ab Method for purification of plasma proteins
WO2021054997A1 (en) * 2019-09-20 2021-03-25 Plasma Technologies, Llc Compositions and methods for generating modified cryo-poor plasma

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3803115A (en) * 1972-05-17 1974-04-09 Baxter Laboratories Inc Stabilization of ahf using heparin
US4361509A (en) * 1981-12-14 1982-11-30 Scripps Clinic And Research Foundation Ultrapurification of factor VIII using monoclonal antibodies
US4495175A (en) * 1982-08-05 1985-01-22 University Of Rochester Preparation of highly purified human antihemophilic factor
US4543210A (en) * 1984-10-04 1985-09-24 Miles Laboratories, Inc. Process for producing a high purity antihemophilic factor concentrate
US4743680A (en) * 1985-02-01 1988-05-10 New York University Method for purifying antihemophilic factor
US4952675A (en) * 1985-02-01 1990-08-28 New York University Method for purifying antihemophilic factor
CA1293941C (en) * 1985-11-08 1992-01-07 Maria Erlinda Co-Sarno Method for preparing antihemophilic factor (ahf) by cold precipitation and for improving solubility of recovered ahf product
NL8701915A (nl) * 1987-08-14 1989-03-01 Waander Riethorst Adsorbensmateriaal en toepassing daarvan voor het isoleren van stollingsfaktoren.
DE3878245D1 (de) * 1988-11-05 1993-03-18 Octapharma Ag Verfahren zur herstellung eines hochreinen, nicht infektioesen antihaemophiliefaktors mittels chromatographie.
FR2644064B1 (fr) * 1989-02-17 1994-05-27 Aquitaine Dev Transf Sanguine Procede de fabrication du facteur antihemophilique fviiic ayant une tres haute purete et facteur antihemophilique fviiic ainsi obtenu, ainsi que composition pharmaceutique le contenant
FR2650393A1 (fr) * 1989-07-28 1991-02-01 Herault Ctre Rgl Transfusion S Methode de purification du facteur vii (f viii) par chromatographie echangeuse d'ions

Also Published As

Publication number Publication date
US5259951A (en) 1993-11-09
JPH04243899A (ja) 1992-08-31
IT9020610A1 (it) 1991-12-12
EP0468181A3 (en) 1992-06-24
CA2044191A1 (en) 1991-12-13
EP0468181A2 (en) 1992-01-29
IT9020610A0 (it) 1990-06-12

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Legal Events

Date Code Title Description
0001 Granted
TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19971128