SE9403915D0 - Process A - Google Patents
Process AInfo
- Publication number
- SE9403915D0 SE9403915D0 SE9403915A SE9403915A SE9403915D0 SE 9403915 D0 SE9403915 D0 SE 9403915D0 SE 9403915 A SE9403915 A SE 9403915A SE 9403915 A SE9403915 A SE 9403915A SE 9403915 D0 SE9403915 D0 SE 9403915D0
- Authority
- SE
- Sweden
- Prior art keywords
- factor viii
- pct
- date
- recombinant
- protease
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/827—Proteins from mammals or birds
- Y10S530/829—Blood
- Y10S530/83—Plasma; serum
- Y10S530/831—Cohn fractions
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9403915A SE9403915D0 (sv) | 1994-11-14 | 1994-11-14 | Process A |
PCT/SE1995/001351 WO1996015150A1 (en) | 1994-11-14 | 1995-11-14 | Process for purifying factor viii |
DE69534383T DE69534383T2 (de) | 1994-11-14 | 1995-11-14 | Verfahren zur aufreinigung des faktors viii |
US08/809,756 US5831026A (en) | 1994-11-14 | 1995-11-14 | Process for purifying factor VIII |
JP51599396A JP3787154B2 (ja) | 1994-11-14 | 1995-11-14 | Viii因子の精製方法 |
CA2202875A CA2202875C (en) | 1994-11-14 | 1995-11-14 | Process for purifying factor viii |
AT95937286T ATE302216T1 (de) | 1994-11-14 | 1995-11-14 | Verfahren zur aufreinigung des faktors viii |
AU39439/95A AU691692B2 (en) | 1994-11-14 | 1995-11-14 | Process for purifying factor VIII |
NZ295811A NZ295811A (en) | 1994-11-14 | 1995-11-14 | Protease resistant factor viii composition containing inhibitors of zinc dependent proteases added to a solution after harvest |
MX9703552A MX9703552A (es) | 1994-11-14 | 1995-11-14 | Proceso de purificacion de factor viii. |
EP95937286A EP0784633B1 (en) | 1994-11-14 | 1995-11-14 | Process for purifying factor viii |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9403915A SE9403915D0 (sv) | 1994-11-14 | 1994-11-14 | Process A |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9403915D0 true SE9403915D0 (sv) | 1994-11-14 |
Family
ID=20395964
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9403915A SE9403915D0 (sv) | 1994-11-14 | 1994-11-14 | Process A |
Country Status (11)
Country | Link |
---|---|
US (1) | US5831026A (sv) |
EP (1) | EP0784633B1 (sv) |
JP (1) | JP3787154B2 (sv) |
AT (1) | ATE302216T1 (sv) |
AU (1) | AU691692B2 (sv) |
CA (1) | CA2202875C (sv) |
DE (1) | DE69534383T2 (sv) |
MX (1) | MX9703552A (sv) |
NZ (1) | NZ295811A (sv) |
SE (1) | SE9403915D0 (sv) |
WO (1) | WO1996015150A1 (sv) |
Families Citing this family (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6605222B1 (en) * | 1998-05-20 | 2003-08-12 | Baxter Aktiengesellschaft | Method for producing a factor VIII/von Willebrand factor complex |
US6586573B1 (en) | 1999-02-22 | 2003-07-01 | Baxter International Inc. | Albumin-free Factor VIII formulations |
EP1172443A4 (en) * | 1999-03-19 | 2004-11-17 | Yamanouchi Pharma Co Ltd | METHOD FOR SCREENING AN INHIBITOR OF THE CYSTEIN PROTEASE |
US6338964B1 (en) * | 1999-05-07 | 2002-01-15 | Bayer Corporation | Process and medium for mammalian cell culture under low dissolved carbon dioxide concentration |
HUP0402315A3 (en) * | 2001-12-21 | 2009-03-30 | Novo Nordisk Healthcare Ag | Liquid composition of factor vii polypeptides |
KR20040065278A (ko) * | 2001-12-21 | 2004-07-21 | 노보 노르디스크 에이/에스 | 변경된 인자 ⅶ 폴리펩티드의 액체 조성물 |
US20040009918A1 (en) * | 2002-05-03 | 2004-01-15 | Hanne Nedergaard | Stabilised solid compositions of modified factor VII |
CN101912601B (zh) | 2002-06-21 | 2012-08-29 | 诺和诺德医疗保健公司 | 因子vii多肽的稳定化固体组合物 |
EP1605968A2 (en) * | 2003-03-18 | 2005-12-21 | Novo Nordisk Health Care AG | Liquid, aqueous, pharmaceutical compositions of factor vii polypeptides |
US7897734B2 (en) * | 2003-03-26 | 2011-03-01 | Novo Nordisk Healthcare Ag | Method for the production of proteins |
KR20060015574A (ko) * | 2003-05-23 | 2006-02-17 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 용액 중 단백질 안정화 |
JP4658041B2 (ja) * | 2003-06-25 | 2011-03-23 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | Vii因子ポリペプチドの液体組成物 |
ES2335994T3 (es) * | 2003-07-01 | 2010-04-07 | Novo Nordisk Health Care Ag | Composicion farmaceutica liquida, acuosa de polipeptidos factor vii. |
JP5653572B2 (ja) * | 2003-08-14 | 2015-01-14 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 第vii因子ポリペプチドの液状水性医薬組成物 |
ES2229931B1 (es) * | 2003-10-03 | 2006-01-16 | Grifols, S.A. | Composicion liquida bilogicamente estable de fviii, de fvw o del complejo fviii/fvw humanos. |
KR20150138427A (ko) * | 2003-12-19 | 2015-12-09 | 노보 노르디스크 헬스 케어 악티엔게젤샤프트 | 인자 vii 폴리펩티드의 안정화된 조성물 |
EP1707634A1 (en) | 2005-03-29 | 2006-10-04 | Octapharma AG | Method for isolation of recombinantly produced proteins |
WO2008135498A2 (en) * | 2007-05-04 | 2008-11-13 | Novo Nordisk A/S | Prevention of protein degradation in mammalian cell cultures |
EP2113564A1 (en) * | 2008-05-01 | 2009-11-04 | Arecor Limited | Protein formulation |
US8329871B2 (en) * | 2008-06-24 | 2012-12-11 | Octapharma Ag | Process of purifying coagulation factor VIII |
WO2010020690A1 (en) | 2008-08-21 | 2010-02-25 | Octapharma Ag | Recombinantly produced human factor viii and ix |
ATE551050T1 (de) * | 2008-09-03 | 2012-04-15 | Octapharma Ag | Stabilisierte zusammensetzungen für rekombinant hergestellten faktor viii |
MX339060B (es) | 2008-11-07 | 2016-05-09 | Baxter Int | Formulaciones del factor viii. |
GB0915480D0 (en) | 2009-09-04 | 2009-10-07 | Arecor Ltd | Stable formulation of factor viii |
BRPI1105317A2 (pt) | 2011-01-24 | 2013-04-30 | Fundacco Hemoct De Ribeirco Preto | produÇço estÁvel e em larga escala de fviii humano em linhagem celular humana sk-hep-1 |
Family Cites Families (26)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4289691A (en) * | 1980-01-18 | 1981-09-15 | The Canadian Red Cross Society | Method of obtaining intermediate purity factor VIII |
US4406886A (en) * | 1983-01-14 | 1983-09-27 | University Patents, Inc. | Purification of antihemophilia factor VIII by precipitation with zinc ions |
FI86885C (sv) * | 1984-04-20 | 1992-10-26 | Genentech Inc | Förfarande för framställning av human rekombinantfaktor VIII och nukle insyrasekvenser och vektorer använd därtill |
US5149787A (en) * | 1984-05-22 | 1992-09-22 | The Blood Center Research Foundation | Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing |
US4710381A (en) * | 1984-05-22 | 1987-12-01 | The Blood Center Of Southeastern Wisconsin | Method for maintaining intact, non-degraded factor VIII/von-Willebrand factor during blood processing |
SE8501050D0 (sv) * | 1985-03-05 | 1985-03-05 | Kabivitrum Ab | Biologically active fragments of human antihemophilic factor and method for preparation thereof |
CA1329760C (en) * | 1987-10-29 | 1994-05-24 | Ted C. K. Lee | Plasma and recombinant protein formulations in high ionic strength media |
US4877608A (en) * | 1987-11-09 | 1989-10-31 | Rorer Pharmaceutical Corporation | Pharmaceutical plasma protein formulations in low ionic strength media |
US4981951A (en) * | 1988-04-14 | 1991-01-01 | Miles Inc. | Lectin affinity chromatography of factor VIII |
WO1990002175A1 (en) * | 1988-08-16 | 1990-03-08 | Novo Nordisk A/S | A method of producing polypeptides by culturing eukaryotic cells in the presence of protease inhibitors |
GB8827305D0 (en) * | 1988-11-23 | 1988-12-29 | British Bio Technology | Compounds |
US5110907A (en) * | 1989-08-01 | 1992-05-05 | Alpha Therapeutic Corporation | Factor viii complex purification using heparin affinity chromatography |
DE3926034C3 (de) * | 1989-08-07 | 1996-11-21 | Behringwerke Ag | Verfahren zur Herstellung eines stabilen Faktors VIII |
SE465222C5 (sv) * | 1989-12-15 | 1998-02-10 | Pharmacia & Upjohn Ab | Ett rekombinant, humant faktor VIII-derivat och förfarande för dess framställning |
IT1248723B (it) * | 1990-06-12 | 1995-01-26 | Scalvo S P A | Processo per la purificazione del fattore viii e fattore viii ottenuto con tale processo |
EP0575405A1 (en) * | 1991-02-04 | 1993-12-29 | Berlex Laboratories, Inc. | Endothelin converting enzyme |
SE468050C (sv) * | 1991-03-15 | 1998-02-11 | Pharmacia & Upjohn Ab | Rekombinant derivat av human faktor VIII |
CA2078721A1 (en) * | 1991-09-24 | 1993-03-25 | Hiroshi Yonemura | Process for preparing human coagulation factor viii protein complex |
US5278289A (en) * | 1991-11-12 | 1994-01-11 | Johnson Alan J | Antihemophilic factor stabilization |
US5399670A (en) * | 1992-04-30 | 1995-03-21 | Alpha Therapeutic Corporation | Solubilization and stabilization of factor VIII complex |
US5288853A (en) * | 1992-04-30 | 1994-02-22 | Alpha Therapeutic Corporation | Factor viii purification process |
GB9211538D0 (en) * | 1992-06-01 | 1992-07-15 | Blake David R | Antiinflammatory agent |
WO1994007510A1 (en) * | 1992-10-02 | 1994-04-14 | Kabi Pharmacia Ab | Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer |
SE9301581D0 (sv) * | 1993-05-07 | 1993-05-07 | Kabi Pharmacia Ab | Protein formulation |
SE504074C2 (sv) * | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
IL113010A (en) * | 1994-03-31 | 1999-10-28 | Pharmacia & Upjohn Ab | Pharmaceutical formulation comprising factor viii with an activity of at least 500iu/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
-
1994
- 1994-11-14 SE SE9403915A patent/SE9403915D0/sv unknown
-
1995
- 1995-11-14 WO PCT/SE1995/001351 patent/WO1996015150A1/en active IP Right Grant
- 1995-11-14 CA CA2202875A patent/CA2202875C/en not_active Expired - Lifetime
- 1995-11-14 AT AT95937286T patent/ATE302216T1/de active
- 1995-11-14 JP JP51599396A patent/JP3787154B2/ja not_active Expired - Lifetime
- 1995-11-14 EP EP95937286A patent/EP0784633B1/en not_active Expired - Lifetime
- 1995-11-14 MX MX9703552A patent/MX9703552A/es unknown
- 1995-11-14 US US08/809,756 patent/US5831026A/en not_active Expired - Lifetime
- 1995-11-14 NZ NZ295811A patent/NZ295811A/en not_active IP Right Cessation
- 1995-11-14 DE DE69534383T patent/DE69534383T2/de not_active Expired - Lifetime
- 1995-11-14 AU AU39439/95A patent/AU691692B2/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
WO1996015150A1 (en) | 1996-05-23 |
JP3787154B2 (ja) | 2006-06-21 |
NZ295811A (en) | 1998-08-26 |
AU3943995A (en) | 1996-06-06 |
US5831026A (en) | 1998-11-03 |
EP0784633A1 (en) | 1997-07-23 |
CA2202875C (en) | 2011-03-15 |
CA2202875A1 (en) | 1996-05-23 |
EP0784633B1 (en) | 2005-08-17 |
JPH10509144A (ja) | 1998-09-08 |
ATE302216T1 (de) | 2005-09-15 |
MX9703552A (es) | 1997-08-30 |
AU691692B2 (en) | 1998-05-21 |
DE69534383T2 (de) | 2006-05-24 |
DE69534383D1 (de) | 2005-09-22 |
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