DE69632629D1 - Thrombin zusammensetzung - Google Patents

Thrombin zusammensetzung

Info

Publication number
DE69632629D1
DE69632629D1 DE69632629T DE69632629T DE69632629D1 DE 69632629 D1 DE69632629 D1 DE 69632629D1 DE 69632629 T DE69632629 T DE 69632629T DE 69632629 T DE69632629 T DE 69632629T DE 69632629 D1 DE69632629 D1 DE 69632629D1
Authority
DE
Germany
Prior art keywords
pct
sec
factor
calcium ions
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69632629T
Other languages
English (en)
Other versions
DE69632629T2 (de
Inventor
Randle Macgregor
Charles Hardy
Olive Drummond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Common Services Agency
Original Assignee
Common Services Agency
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Common Services Agency filed Critical Common Services Agency
Publication of DE69632629D1 publication Critical patent/DE69632629D1/de
Application granted granted Critical
Publication of DE69632629T2 publication Critical patent/DE69632629T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6429—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21005—Thrombin (3.4.21.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69632629T 1995-02-24 1996-02-23 Thrombin zusammensetzung Expired - Lifetime DE69632629T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9503750.3A GB9503750D0 (en) 1995-02-24 1995-02-24 Thrombin preparation
GB9503750 1995-02-24
PCT/GB1996/000423 WO1996026269A1 (en) 1995-02-24 1996-02-23 Thrombin preparation

Publications (2)

Publication Number Publication Date
DE69632629D1 true DE69632629D1 (de) 2004-07-08
DE69632629T2 DE69632629T2 (de) 2005-06-09

Family

ID=10770203

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69632629T Expired - Lifetime DE69632629T2 (de) 1995-02-24 1996-02-23 Thrombin zusammensetzung

Country Status (10)

Country Link
US (1) US5907032A (de)
EP (1) EP0813598B1 (de)
JP (1) JP3819935B2 (de)
AT (1) ATE268380T1 (de)
AU (1) AU709673B2 (de)
CA (1) CA2212832C (de)
DE (1) DE69632629T2 (de)
ES (1) ES2218583T3 (de)
GB (1) GB9503750D0 (de)
WO (1) WO1996026269A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6274090B1 (en) * 1998-08-05 2001-08-14 Thermogenesis Corp. Apparatus and method of preparation of stable, long term thrombin from plasma and thrombin formed thereby
DE60032001T2 (de) * 1999-09-27 2007-05-31 Sysmex Corp. Verfahren zur stabilisierung von thrombin
GB0216002D0 (en) * 2002-07-10 2002-08-21 Nat Blood Authority Process and composition
KR20050084954A (ko) 2002-11-14 2005-08-29 자이단호진 가가쿠오요비겟세이료호겐쿠쇼 트롬빈-고정화 생체흡수성 합성 부직포
ES2226587B1 (es) * 2004-10-22 2005-12-16 Probitas Pharma, S.A. Composicion de trombina estable.
CN100383241C (zh) * 2005-11-11 2008-04-23 东北农业大学 猪凝血酶的制备方法
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
US9212357B2 (en) 2012-12-03 2015-12-15 Omrix Biopharmaceuticals Ltd. Thrombin solution and methods of use thereof
US9932388B2 (en) 2014-11-13 2018-04-03 Hemarus Therapeutics Limited Chromatographic process for producing high purity fibrinogen and thrombin

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3843126C3 (de) * 1988-12-22 1994-10-06 Octapharma Ag Verfahren zur Herstellung eines hochreinen Thrombinkonzentrates
DE69011136T3 (de) * 1989-01-13 2003-10-23 Mitsubishi Pharma Corp Verfahren zur Herstellung einer Protein enthaltenden Zusammensetzung.
FR2679251B1 (fr) * 1991-07-18 1993-11-12 Nord Assoc Essor Transfusion San Procede de preparation d'un concentre de thrombine humaine destine a un usage therapeutique.
AT398079B (de) * 1991-11-04 1994-09-26 Immuno Ag Präparation mit thrombinaktivität sowie verfahren zu ihrer herstellung
US5219995A (en) * 1992-07-14 1993-06-15 Alpha Therapeutic Corporation Plasma fraction purification

Also Published As

Publication number Publication date
ES2218583T3 (es) 2004-11-16
AU709673B2 (en) 1999-09-02
CA2212832A1 (en) 1996-08-29
WO1996026269A1 (en) 1996-08-29
EP0813598A1 (de) 1997-12-29
ATE268380T1 (de) 2004-06-15
EP0813598B1 (de) 2004-06-02
AU4836496A (en) 1996-09-11
US5907032A (en) 1999-05-25
CA2212832C (en) 2011-01-18
JP3819935B2 (ja) 2006-09-13
GB9503750D0 (en) 1995-04-12
JPH11500619A (ja) 1999-01-19
DE69632629T2 (de) 2005-06-09

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