JP2014522413A5 - - Google Patents
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- JP2014522413A5 JP2014522413A5 JP2014514905A JP2014514905A JP2014522413A5 JP 2014522413 A5 JP2014522413 A5 JP 2014522413A5 JP 2014514905 A JP2014514905 A JP 2014514905A JP 2014514905 A JP2014514905 A JP 2014514905A JP 2014522413 A5 JP2014522413 A5 JP 2014522413A5
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- Prior art keywords
- dimethyl
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161494775P | 2011-06-08 | 2011-06-08 | |
| US61/494,775 | 2011-06-08 | ||
| PCT/US2012/041715 WO2012170923A1 (en) | 2011-06-08 | 2012-06-08 | Process for preparing high purity and crystalline dimethyl fumarate |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016111809A Division JP2016155868A (ja) | 2011-06-08 | 2016-06-03 | 高純度結晶性ジメチルフマラートの調製方法 |
| JP2018107557A Division JP2018162266A (ja) | 2011-06-08 | 2018-06-05 | 高純度結晶性ジメチルフマラートの調製方法 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| JP2014522413A JP2014522413A (ja) | 2014-09-04 |
| JP2014522413A5 true JP2014522413A5 (https=) | 2015-07-23 |
| JP6385273B2 JP6385273B2 (ja) | 2018-09-05 |
| JP6385273B6 JP6385273B6 (ja) | 2023-12-15 |
Family
ID=47296498
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014514905A Expired - Fee Related JP6385273B6 (ja) | 2011-06-08 | 2012-06-08 | 高純度結晶性ジメチルフマラートの調製方法 |
| JP2016111809A Pending JP2016155868A (ja) | 2011-06-08 | 2016-06-03 | 高純度結晶性ジメチルフマラートの調製方法 |
| JP2018107557A Pending JP2018162266A (ja) | 2011-06-08 | 2018-06-05 | 高純度結晶性ジメチルフマラートの調製方法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016111809A Pending JP2016155868A (ja) | 2011-06-08 | 2016-06-03 | 高純度結晶性ジメチルフマラートの調製方法 |
| JP2018107557A Pending JP2018162266A (ja) | 2011-06-08 | 2018-06-05 | 高純度結晶性ジメチルフマラートの調製方法 |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US9422226B2 (https=) |
| EP (1) | EP2718257B1 (https=) |
| JP (3) | JP6385273B6 (https=) |
| KR (2) | KR20150080037A (https=) |
| CN (1) | CN103649041A (https=) |
| AU (1) | AU2012267524A1 (https=) |
| BR (1) | BR112013031616A2 (https=) |
| CA (1) | CA2838271A1 (https=) |
| CL (1) | CL2013003483A1 (https=) |
| CO (1) | CO6821956A2 (https=) |
| CY (1) | CY1119920T1 (https=) |
| DK (1) | DK2718257T3 (https=) |
| EA (1) | EA201391638A1 (https=) |
| EC (1) | ECSP14013123A (https=) |
| ES (1) | ES2659771T3 (https=) |
| HR (1) | HRP20180203T1 (https=) |
| HU (1) | HUE036085T2 (https=) |
| IL (1) | IL229656A0 (https=) |
| LT (1) | LT2718257T (https=) |
| ME (1) | ME02960B (https=) |
| MX (1) | MX355421B (https=) |
| NO (1) | NO2820009T3 (https=) |
| NZ (1) | NZ618178A (https=) |
| PE (1) | PE20141639A1 (https=) |
| PH (1) | PH12013502498A1 (https=) |
| PL (1) | PL2718257T3 (https=) |
| PT (1) | PT2718257T (https=) |
| RS (1) | RS56972B1 (https=) |
| SG (1) | SG195227A1 (https=) |
| SI (1) | SI2718257T1 (https=) |
| SM (1) | SMT201800098T1 (https=) |
| WO (1) | WO2012170923A1 (https=) |
Families Citing this family (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2526586C (en) | 2003-09-09 | 2010-03-16 | Biogen International Gmbh | The use of fumaric acid derivatives for treating cardiac insufficiency, and asthma |
| PL2316430T3 (pl) | 2004-10-08 | 2012-11-30 | Forward Pharma As | Kompozycje farmaceutyczne o kontrolowanym uwalnianiu, zawierające ester kwasu fumarowego |
| RU2554347C2 (ru) | 2008-08-19 | 2015-06-27 | Ксенопорт, Инк. | Пролекарства метилгидрофумарата, фармацевтические композиции с ними и способы применения |
| KR20150080037A (ko) | 2011-06-08 | 2015-07-08 | 바이오젠 엠에이 인코포레이티드 | 고순도 및 결정질 다이메틸 푸마레이트의 제조 방법 |
| CA2882730C (en) | 2012-08-22 | 2019-12-31 | Arbor Pharmaceuticals, Llc | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| US10945984B2 (en) | 2012-08-22 | 2021-03-16 | Arbor Pharmaceuticals, Llc | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| EP2934503B1 (en) | 2012-12-21 | 2019-04-10 | Biogen MA Inc. | Deuterium substituted fumarate derivatives |
| KR102085557B1 (ko) | 2013-03-14 | 2020-03-06 | 엘커메스 파마 아일랜드 리미티드 | 푸마레이트의 프로드럭 및 다양한 질환을 치료하는데 있어서의 이들의 용도 |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| US10179118B2 (en) | 2013-03-24 | 2019-01-15 | Arbor Pharmaceuticals, Llc | Pharmaceutical compositions of dimethyl fumarate |
| CN104098471A (zh) * | 2013-04-03 | 2014-10-15 | 南京卡文迪许生物工程技术有限公司 | 富马酸二甲酯多晶型物及其制备方法和药物组合物 |
| US9302977B2 (en) | 2013-06-07 | 2016-04-05 | Xenoport, Inc. | Method of making monomethyl fumarate |
| US9421182B2 (en) | 2013-06-21 | 2016-08-23 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| US9416096B2 (en) | 2013-09-06 | 2016-08-16 | Xenoport, Inc. | Crystalline forms of (N,N-Diethylcarbamoyl)methyl methyl (2E)but-2-ene-1,4-dioate, methods of synthesis and use |
| IN2013MU03070A (https=) * | 2013-09-25 | 2015-07-17 | Glenmark Pharmaceuticals Ltd | |
| IN2014CH00308A (https=) * | 2014-01-24 | 2015-07-31 | Shilpa Medicare Ltd | |
| JP6337135B2 (ja) | 2014-02-24 | 2018-06-06 | アルカーメス ファーマ アイルランド リミテッド | フマル酸エステルのスルホンアミドプロドラッグ及びスルフィンアミドプロドラッグ並びに種々の疾患の治療におけるその使用 |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| ES2713157T3 (es) | 2014-02-28 | 2019-05-20 | Banner Life Sciences Llc | Cápsulas blandas entéricas de liberación controlada de ésteres de fumarato |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| WO2015140811A2 (en) * | 2014-03-17 | 2015-09-24 | Biophore India Pharmaceuticals Pvt. Ltd. | An improved process for the synthesis of dimethyl fumarate |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| WO2016001093A1 (en) * | 2014-07-03 | 2016-01-07 | Synthon B.V. | Process for making microcrystalline dimethyl fumarate |
| CN104151165B (zh) * | 2014-08-11 | 2016-08-24 | 广东东阳光药业有限公司 | 制备富马酸二甲酯的方法 |
| CN104761453A (zh) * | 2015-04-22 | 2015-07-08 | 河南中帅医药科技股份有限公司 | 一种富马酸二甲酯晶型及其制备方法 |
| WO2016194004A1 (en) * | 2015-06-01 | 2016-12-08 | Sun Pharmaceutical Industries Ltd. | Pharmaceutical compositions of dimethyl fumarate |
| MX387092B (es) * | 2015-06-17 | 2025-03-19 | Biogen Ma Inc | Particulas de dimetilfumarato y composiciones farmaceuticas de estas. |
| CN106316841A (zh) * | 2015-06-30 | 2017-01-11 | 深圳翰宇药业股份有限公司 | 一种富马酸二甲酯的制备方法 |
| WO2017013672A1 (en) * | 2015-07-23 | 2017-01-26 | Natco Pharma Ltd | Process for the preparation of pharmaceutical grade dimethyl fumarate |
| US10011663B2 (en) | 2016-02-04 | 2018-07-03 | Eastman Chemical Company | Vulcanizing composition containing cyclododecasulfur and improved cyclododecasulfur compound |
| RU2616605C1 (ru) * | 2016-04-07 | 2017-04-18 | Олег Ростиславович Михайлов | Кристаллическая бета - модификация (Е)-диметилбутендиоата, способ её получения и фармацевтическая композиция на её основе |
| CN107285320A (zh) * | 2017-08-02 | 2017-10-24 | 内蒙古新福地科技有限公司 | 一种氟硅酸钠的结晶方法及装置 |
| HUE062926T2 (hu) | 2017-10-10 | 2023-12-28 | Pfizer | Lorlatinib mint szabad bázis hidrátjának kristályos formája |
| US11903918B2 (en) | 2020-01-10 | 2024-02-20 | Banner Life Sciences Llc | Fumarate ester dosage forms with enhanced gastrointestinal tolerability |
| KR102271575B1 (ko) * | 2020-09-16 | 2021-07-01 | 김갑용 | 염의 이온교환법을 이용한 친환경 고효율 에스터화반응 기반의 에스터화합물 제조방법 및 이의 화합물 |
| JP6865489B1 (ja) * | 2020-10-20 | 2021-04-28 | 株式会社エス・ディー・エス バイオテック | ２，３，５，６−テトラクロロ−１，４−ベンゼンジカルボン酸ジメチルの製造方法 |
| CN117550970A (zh) * | 2023-10-30 | 2024-02-13 | 寿光金远东变性淀粉有限公司 | 一种高纯度衣康酸二甲酯的生产方法 |
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| EP2713724A4 (en) | 2011-05-26 | 2015-03-11 | Biogen Idec Inc | METHODS OF TREATING MULTIPLE SCLEROSIS AND PRESERVING AND / OR INCREASING MYELINE CONTENT |
| KR20150080037A (ko) | 2011-06-08 | 2015-07-08 | 바이오젠 엠에이 인코포레이티드 | 고순도 및 결정질 다이메틸 푸마레이트의 제조 방법 |
| CN102432464A (zh) | 2011-12-14 | 2012-05-02 | 费近峰 | 一种富马酸二甲酯的连续生产工艺 |
| CN114146081A (zh) | 2012-02-07 | 2022-03-08 | 比奥根玛公司 | 含有富马酸二甲酯的药物组合物 |
| CN102766050A (zh) | 2012-08-10 | 2012-11-07 | 太仓市运通化工厂 | 一种富马酸二甲酯的合成方法 |
| EP2934503B1 (en) | 2012-12-21 | 2019-04-10 | Biogen MA Inc. | Deuterium substituted fumarate derivatives |
| CN103848739A (zh) | 2014-03-20 | 2014-06-11 | 徐晓宁 | 一种高纯度富马酸二甲酯的生产方法 |
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- 2012-06-08 KR KR1020147000390A patent/KR20140035995A/ko not_active Ceased
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