ME02960B - Postupak za pripremu visoko-čistog i kristalnog dimetil fumarata - Google Patents
Postupak za pripremu visoko-čistog i kristalnog dimetil fumarataInfo
- Publication number
- ME02960B ME02960B MEP-2018-39A MEP201839A ME02960B ME 02960 B ME02960 B ME 02960B ME P201839 A MEP201839 A ME P201839A ME 02960 B ME02960 B ME 02960B
- Authority
- ME
- Montenegro
- Prior art keywords
- dimethylum
- fumarate
- preparation
- purity crystalline
- purity
- Prior art date
Links
- VZCYOOQTPOCHFL-OWOJBTEDSA-L fumarate(2-) Chemical compound [O-]C(=O)\C=C\C([O-])=O VZCYOOQTPOCHFL-OWOJBTEDSA-L 0.000 title 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/62—Use of additives, e.g. for stabilisation
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/28—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group
- C07C67/297—Preparation of carboxylic acid esters by modifying the hydroxylic moiety of the ester, such modification not being an introduction of an ester group by splitting-off hydrogen or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/48—Separation; Purification; Stabilisation; Use of additives
- C07C67/52—Separation; Purification; Stabilisation; Use of additives by change in the physical state, e.g. crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/593—Dicarboxylic acid esters having only one carbon-to-carbon double bond
- C07C69/60—Maleic acid esters; Fumaric acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/52—Esters of acyclic unsaturated carboxylic acids having the esterified carboxyl group bound to an acyclic carbon atom
- C07C69/604—Polycarboxylic acid esters, the acid moiety containing more than two carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Crystallography & Structural Chemistry (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161494775P | 2011-06-08 | 2011-06-08 | |
| EP12796164.7A EP2718257B1 (en) | 2011-06-08 | 2012-06-08 | Process for preparing high purity and crystalline dimethyl fumarate |
| PCT/US2012/041715 WO2012170923A1 (en) | 2011-06-08 | 2012-06-08 | Process for preparing high purity and crystalline dimethyl fumarate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02960B true ME02960B (me) | 2018-07-20 |
Family
ID=47296498
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2018-39A ME02960B (me) | 2011-06-08 | 2012-06-08 | Postupak za pripremu visoko-čistog i kristalnog dimetil fumarata |
Country Status (32)
| Country | Link |
|---|---|
| US (1) | US9422226B2 (https=) |
| EP (1) | EP2718257B1 (https=) |
| JP (3) | JP6385273B6 (https=) |
| KR (2) | KR20150080037A (https=) |
| CN (1) | CN103649041A (https=) |
| AU (1) | AU2012267524A1 (https=) |
| BR (1) | BR112013031616A2 (https=) |
| CA (1) | CA2838271A1 (https=) |
| CL (1) | CL2013003483A1 (https=) |
| CO (1) | CO6821956A2 (https=) |
| CY (1) | CY1119920T1 (https=) |
| DK (1) | DK2718257T3 (https=) |
| EA (1) | EA201391638A1 (https=) |
| EC (1) | ECSP14013123A (https=) |
| ES (1) | ES2659771T3 (https=) |
| HR (1) | HRP20180203T1 (https=) |
| HU (1) | HUE036085T2 (https=) |
| IL (1) | IL229656A0 (https=) |
| LT (1) | LT2718257T (https=) |
| ME (1) | ME02960B (https=) |
| MX (1) | MX355421B (https=) |
| NO (1) | NO2820009T3 (https=) |
| NZ (1) | NZ618178A (https=) |
| PE (1) | PE20141639A1 (https=) |
| PH (1) | PH12013502498A1 (https=) |
| PL (1) | PL2718257T3 (https=) |
| PT (1) | PT2718257T (https=) |
| RS (1) | RS56972B1 (https=) |
| SG (1) | SG195227A1 (https=) |
| SI (1) | SI2718257T1 (https=) |
| SM (1) | SMT201800098T1 (https=) |
| WO (1) | WO2012170923A1 (https=) |
Families Citing this family (38)
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|---|---|---|---|---|
| SI1663197T1 (sl) | 2003-09-09 | 2008-06-30 | Biogen Idec Internat Gmbh | Uporaba derivatov fumarne kisline za zdravljenje sräśne insuficience in astme |
| LT2801354T (lt) | 2004-10-08 | 2017-06-26 | Forward Pharma A/S | Kontroliuojamo atpalaidavimo farmacinės kompozicijos, apimančios fumaro rūgšties esterį |
| HRP20140640T1 (hr) | 2008-08-19 | 2014-11-21 | Xenoport, Inc. | Prolijekovi monometil estera fumarne kiseline, farmaceutski sastavi iz toga i postupci njihove uporabe |
| SMT201800098T1 (it) | 2011-06-08 | 2018-03-08 | Biogen Ma Inc | Processo per la preparazione di dimetilfumarato cristallino e con purezza elevata |
| AU2013305684B2 (en) | 2012-08-22 | 2016-11-24 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| US10945984B2 (en) | 2012-08-22 | 2021-03-16 | Arbor Pharmaceuticals, Llc | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| AR094277A1 (es) | 2012-12-21 | 2015-07-22 | Biogen Idec Inc | Derivados de fumarato sustituidos con deuterio |
| BR112015022854A2 (pt) | 2013-03-14 | 2017-07-18 | Alkermes Pharma Ireland Ltd | pró-farmacos de fumaratos e uso do mesmo no tratamento de várias doenças |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| WO2014160633A1 (en) | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Pharmaceutical compositions of dimethyl fumarate |
| CN104098471A (zh) * | 2013-04-03 | 2014-10-15 | 南京卡文迪许生物工程技术有限公司 | 富马酸二甲酯多晶型物及其制备方法和药物组合物 |
| WO2014197860A1 (en) | 2013-06-07 | 2014-12-11 | Xenoport, Inc. | Method of making monomethyl fumarate |
| WO2014205392A1 (en) | 2013-06-21 | 2014-12-24 | Xenoport, Inc. | Cocrystals of dimethyl fumarate |
| EP3041467A1 (en) | 2013-09-06 | 2016-07-13 | XenoPort, Inc. | Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use |
| IN2013MU03070A (https=) * | 2013-09-25 | 2015-07-17 | Glenmark Pharmaceuticals Ltd | |
| EP3097075A4 (en) * | 2014-01-24 | 2017-06-21 | Shilpa Medicare Limited | Process for preparation of dimethyl-(e)-butenedioate |
| JP6337135B2 (ja) | 2014-02-24 | 2018-06-06 | アルカーメス ファーマ アイルランド リミテッド | フマル酸エステルのスルホンアミドプロドラッグ及びスルフィンアミドプロドラッグ並びに種々の疾患の治療におけるその使用 |
| AU2015222880B2 (en) | 2014-02-28 | 2016-11-24 | Banner Life Sciences Llc | Controlled release enteric soft capsules of fumarate esters |
| US10098863B2 (en) | 2014-02-28 | 2018-10-16 | Banner Life Sciences Llc | Fumarate esters |
| US9326947B1 (en) | 2014-02-28 | 2016-05-03 | Banner Life Sciences Llc | Controlled release fumarate esters |
| US9636318B2 (en) | 2015-08-31 | 2017-05-02 | Banner Life Sciences Llc | Fumarate ester dosage forms |
| US10626076B2 (en) * | 2014-03-17 | 2020-04-21 | Biophore India Pharmaeuticals Pvt. Ltd. | Process for the synthesis of dimethyl fumarate |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| EP3164378A1 (en) * | 2014-07-03 | 2017-05-10 | Synthon B.V. | Process for making microcrystalline dimethyl fumarate |
| CN104151165B (zh) * | 2014-08-11 | 2016-08-24 | 广东东阳光药业有限公司 | 制备富马酸二甲酯的方法 |
| CN104761453A (zh) * | 2015-04-22 | 2015-07-08 | 河南中帅医药科技股份有限公司 | 一种富马酸二甲酯晶型及其制备方法 |
| CA2987895A1 (en) * | 2015-06-01 | 2016-12-08 | Sun Pharmaceutical Industries Ltd. | Pharmaceutical compositions of dimethyl fumarate |
| MX387092B (es) | 2015-06-17 | 2025-03-19 | Biogen Ma Inc | Particulas de dimetilfumarato y composiciones farmaceuticas de estas. |
| CN106316841A (zh) * | 2015-06-30 | 2017-01-11 | 深圳翰宇药业股份有限公司 | 一种富马酸二甲酯的制备方法 |
| WO2017013672A1 (en) * | 2015-07-23 | 2017-01-26 | Natco Pharma Ltd | Process for the preparation of pharmaceutical grade dimethyl fumarate |
| US10011663B2 (en) | 2016-02-04 | 2018-07-03 | Eastman Chemical Company | Vulcanizing composition containing cyclododecasulfur and improved cyclododecasulfur compound |
| RU2616605C1 (ru) * | 2016-04-07 | 2017-04-18 | Олег Ростиславович Михайлов | Кристаллическая бета - модификация (Е)-диметилбутендиоата, способ её получения и фармацевтическая композиция на её основе |
| CN107285320A (zh) * | 2017-08-02 | 2017-10-24 | 内蒙古新福地科技有限公司 | 一种氟硅酸钠的结晶方法及装置 |
| JP7153069B2 (ja) * | 2017-10-10 | 2022-10-13 | ファイザー・インク | ロルラチニブ遊離塩基水和物の結晶形態 |
| US11903918B2 (en) | 2020-01-10 | 2024-02-20 | Banner Life Sciences Llc | Fumarate ester dosage forms with enhanced gastrointestinal tolerability |
| KR102271575B1 (ko) * | 2020-09-16 | 2021-07-01 | 김갑용 | 염의 이온교환법을 이용한 친환경 고효율 에스터화반응 기반의 에스터화합물 제조방법 및 이의 화합물 |
| JP6865489B1 (ja) * | 2020-10-20 | 2021-04-28 | 株式会社エス・ディー・エス バイオテック | ２，３，５，６−テトラクロロ−１，４−ベンゼンジカルボン酸ジメチルの製造方法 |
| CN117550970A (zh) * | 2023-10-30 | 2024-02-13 | 寿光金远东变性淀粉有限公司 | 一种高纯度衣康酸二甲酯的生产方法 |
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