JP2013527853A5 - - Google Patents

Download PDF

Info

Publication number
JP2013527853A5
JP2013527853A5 JP2013509240A JP2013509240A JP2013527853A5 JP 2013527853 A5 JP2013527853 A5 JP 2013527853A5 JP 2013509240 A JP2013509240 A JP 2013509240A JP 2013509240 A JP2013509240 A JP 2013509240A JP 2013527853 A5 JP2013527853 A5 JP 2013527853A5
Authority
JP
Japan
Prior art keywords
array
micro
pth
base
water
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013509240A
Other languages
English (en)
Japanese (ja)
Other versions
JP6327852B2 (ja
JP2013527853A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/035261 external-priority patent/WO2011140274A2/en
Publication of JP2013527853A publication Critical patent/JP2013527853A/ja
Publication of JP2013527853A5 publication Critical patent/JP2013527853A5/ja
Application granted granted Critical
Publication of JP6327852B2 publication Critical patent/JP6327852B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013509240A 2010-05-04 2011-05-04 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス Active JP6327852B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33122610P 2010-05-04 2010-05-04
US61/331,226 2010-05-04
PCT/US2011/035261 WO2011140274A2 (en) 2010-05-04 2011-05-04 Method and device for transdermal delivery of parathyroid hormone using a microprojection array

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016135849A Division JP6279662B2 (ja) 2010-05-04 2016-07-08 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス

Publications (3)

Publication Number Publication Date
JP2013527853A JP2013527853A (ja) 2013-07-04
JP2013527853A5 true JP2013527853A5 (cg-RX-API-DMAC7.html) 2014-06-26
JP6327852B2 JP6327852B2 (ja) 2018-05-23

Family

ID=44902423

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013509240A Active JP6327852B2 (ja) 2010-05-04 2011-05-04 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス
JP2016135849A Active JP6279662B2 (ja) 2010-05-04 2016-07-08 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016135849A Active JP6279662B2 (ja) 2010-05-04 2016-07-08 微小突起アレイを使用した副甲状腺ホルモンの経皮送達のための方法及びデバイス

Country Status (7)

Country Link
US (4) US9687641B2 (cg-RX-API-DMAC7.html)
EP (1) EP2566501B1 (cg-RX-API-DMAC7.html)
JP (2) JP6327852B2 (cg-RX-API-DMAC7.html)
AU (1) AU2011248108B2 (cg-RX-API-DMAC7.html)
CA (1) CA2798145C (cg-RX-API-DMAC7.html)
ES (1) ES2719595T3 (cg-RX-API-DMAC7.html)
WO (1) WO2011140274A2 (cg-RX-API-DMAC7.html)

Families Citing this family (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008241470B2 (en) 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
WO2011140274A2 (en) * 2010-05-04 2011-11-10 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
EP3106159A1 (en) 2010-05-12 2016-12-21 Radius Health, Inc. Therapeutic regimens
AU2011312490B2 (en) 2010-09-28 2015-06-25 Radius Pharmaceuticals, Inc. Selective androgen receptor modulators
JP6265740B2 (ja) 2011-10-06 2018-01-24 久光製薬株式会社 アプリケータ
US9675675B2 (en) 2011-11-30 2017-06-13 3M Innovative Properties Company Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same
EP2865409B1 (en) 2012-06-22 2020-06-24 Toppan Printing Co., Ltd. Needle-shaped body and manufacturing method for needle-shaped body
KR102265808B1 (ko) 2012-12-21 2021-06-16 코리움, 인크. 치료제의 전달을 위한 마이크로어레이 및 그것의 사용방법
US10183156B2 (en) 2013-02-28 2019-01-22 Sorrento Therapeutics, Inc. Transdermal drug delivery device
EP2968887B1 (en) 2013-03-12 2022-05-04 Corium, Inc. Microprojection applicators
EP2974768A4 (en) * 2013-03-12 2017-05-17 Takeda Pharmaceutical Company Limited Micro-needle patch
EP4194028A1 (en) 2013-03-15 2023-06-14 Corium Pharma Solutions, Inc. Multiple impact microprojection applicators
JP2016512754A (ja) * 2013-03-15 2016-05-09 コリウム インターナショナル, インコーポレイテッド 治療剤の送達のためのマイクロアレイ、使用方法および製造方法
MX2015012433A (es) 2013-03-15 2016-02-03 Corium Int Inc Matriz de microestructura para suministro de agentes activos.
CN105246458B (zh) 2013-03-15 2020-09-15 考里安公司 用于治疗剂递送的微阵列及其使用方法
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
WO2015012112A1 (ja) * 2013-07-22 2015-01-29 凸版印刷株式会社 マイクロニードル、および、マイクロニードルの製造方法
US20170049695A1 (en) * 2014-02-27 2017-02-23 Hisamitsu Pharmaceutical Co., Inc. Microneedle sheet
FI3122426T3 (fi) 2014-03-28 2023-03-31 Univ Duke Rintasyövän hoitaminen käyttäen selektiivisiä estrogeenin reseptorin modulaattoreita
EP3193828B8 (en) 2014-08-29 2023-04-05 Corium Pharma Solutions, Inc. Microstructure array for delivery of active agents
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
MA41818A (fr) * 2015-03-27 2018-01-30 Leo Pharma As Timbre à micro-aiguilles pour administration d'un principe actif à la peau
RU2747228C2 (ru) 2015-04-29 2021-04-29 Радиус Фармасьютикалз, Инк. Способы лечения рака
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
WO2017018086A1 (ja) * 2015-07-29 2017-02-02 日本写真印刷株式会社 マイクロニードルシート
JP6799005B2 (ja) * 2015-12-15 2020-12-09 久光製薬株式会社 マイクロニードル・シート
US20170348218A1 (en) * 2016-06-03 2017-12-07 Sanova Bioscience Inc Microneedle patch containing hyaluronic acid for cosmetic use
EP3474841B1 (en) 2016-06-22 2022-03-16 Ellipses Pharma Ltd Ar+ breast cancer treatment methods
KR102571833B1 (ko) 2016-12-16 2023-08-30 소렌토 쎄라퓨틱스, 인코포레이티드 제어기 조립체를 가지는 유체 전달 장치 및 그 이용 방법
CN110382034B (zh) 2016-12-16 2023-01-17 索伦托治疗有限公司 用于给予适合治疗偏头痛或丛集性头痛的药物的流体输送装置
AU2017378022B2 (en) * 2016-12-16 2023-06-29 Vivasor, Inc. Fluid delivery apparatus and method of assembly
AU2017378018B2 (en) 2016-12-16 2023-06-22 Vivasor, Inc. Fluid delivery apparatus having a gas extraction device and method of use
KR20190088073A (ko) 2016-12-16 2019-07-25 소렌토 쎄라퓨틱스, 인코포레이티드 유체 전달 장치용 부착 밴드 및 그 이용 방법
EP3554620A4 (en) 2016-12-16 2020-07-15 Sorrento Therapeutics, Inc. APPLICATION DEVICE FOR LIQUID DISPENSER AND METHOD FOR USE
LT3565542T (lt) 2017-01-05 2024-07-10 Radius Pharmaceuticals, Inc. Polimorfinės rad1901-2hcl formos
KR101776659B1 (ko) 2017-02-27 2017-09-11 주식회사 쿼드메디슨 마이크로 니들 및 이의 제조방법
WO2020005973A1 (en) 2018-06-25 2020-01-02 Corium, Inc. Hybrid method of forming microstructure array molds, methods of making microstructure arrays, and methods of use
JP7473486B2 (ja) 2018-07-04 2024-04-23 ラジウス ファーマシューティカルズ,インコーポレイテッド Rad1901-2hclの多形形態
KR20210127961A (ko) 2019-02-12 2021-10-25 래디어스 파마슈티컬스, 인코포레이티드 방법 및 화합물
WO2020231939A1 (en) * 2019-05-10 2020-11-19 Cornell University Nanoprojection devices as well as methods of making and using such devices
US20230073125A1 (en) * 2019-10-29 2023-03-09 The Regents Of The University Of California Periodontal micropatch and uses thereof
CN115734798A (zh) 2020-04-28 2023-03-03 提克纳有限责任公司 微针组件
KR20240046503A (ko) * 2021-08-20 2024-04-09 코스메드 파마소티컬 씨오 쩜 엘티디 고성능 마이크로니들 어레이
CN116510014A (zh) * 2022-01-28 2023-08-01 苏州悦肤达医疗科技有限公司 药物组合物、微针制剂、微针给药系统、制备方法和应用

Family Cites Families (464)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1554510A (en) 1924-04-23 1925-09-22 Elsie W Kirby Massaging device
US1770632A (en) 1928-07-02 1930-07-15 Arthur E Smith Ampul syringe
US2046240A (en) 1932-07-01 1936-06-30 Thomas W Bayley Abrasive article
US2434407A (en) 1946-01-05 1948-01-13 Hofe George Douglas Depilatory device
NL200971A (cg-RX-API-DMAC7.html) 1954-10-04
JPS4637758Y1 (cg-RX-API-DMAC7.html) 1967-12-13 1971-12-27
US3675766A (en) 1970-02-04 1972-07-11 Sol Roy Rosenthal Multiple puncture injector device
US3704194A (en) 1970-07-02 1972-11-28 Gen Electric Perforated reinforced plastic member and method for making
US3873255A (en) 1971-01-27 1975-03-25 Johnson & Johnson Apparatus for producing nonwoven fabric
US3964482A (en) 1971-05-17 1976-06-22 Alza Corporation Drug delivery device
BE795384A (fr) 1972-02-14 1973-08-13 Ici Ltd Pansements
DE2319591C2 (de) 1973-04-18 1982-02-25 Kirchner & Wilhelm, 7000 Stuttgart Medizinischer Apparat
FR2232331B1 (cg-RX-API-DMAC7.html) 1973-06-06 1978-03-24 Guerin A Ets
AT347283B (de) 1975-03-07 1978-12-27 Collo Gmbh Schaumstoffkoerper fuer reinigungs-, scheuer- und/oder polierzwecke u. dgl.
US4151240A (en) 1976-10-19 1979-04-24 The Procter & Gamble Company Method for debossing and perforating a running ribbon of thermoplastic film
US4180232A (en) 1977-01-13 1979-12-25 Hardigg James S Truss panel mold
US4117841A (en) 1977-02-07 1978-10-03 Anthony Perrotta Medicated bandage pocket
JPS5428369A (en) 1977-08-03 1979-03-02 Yamakawa Tsuneko Method of forming needleelike projection of thermoplastic resin on sheet
US4342314A (en) 1979-03-05 1982-08-03 The Procter & Gamble Company Resilient plastic web exhibiting fiber-like properties
US4402696A (en) 1979-10-15 1983-09-06 Gulko Bruce N Folded applicator
US4381963A (en) 1980-07-30 1983-05-03 The University Of Rochester Micro fabrication molding process
US4509908A (en) 1981-02-02 1985-04-09 The Procter & Gamble Company Apparatus for uniformly debossing and aperturing a resilient plastic web
US4395215A (en) 1981-02-02 1983-07-26 The Procter & Gamble Company Film forming structure for uniformly debossing and selectively aperturing a resilient plastic web and method for its construction
US4463045A (en) 1981-03-02 1984-07-31 The Procter & Gamble Company Macroscopically expanded three-dimensional plastic web exhibiting non-glossy visible surface and cloth-like tactile impression
US4460370A (en) 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication application cell
US4460368A (en) 1981-10-29 1984-07-17 Almedco, Inc. Trans-dermal medication system
US4966159A (en) 1981-12-14 1990-10-30 Maganias Nicholas H Allergy test strip
US4585991A (en) 1982-06-03 1986-04-29 Texas Instruments Incorporated Solid state multiprobe testing apparatus
FR2535602B1 (fr) 1982-11-05 1986-06-13 Stallergenes Lab Dispositif scarificateur
US4556441A (en) 1983-01-24 1985-12-03 Faasse Jr Adrian L Pharmaceutical packaging method
US4515168A (en) 1983-07-22 1985-05-07 Chester Martin H Clamp-on nerve stimulator and locator
US4708716A (en) 1983-08-18 1987-11-24 Drug Delivery Systems Inc. Transdermal drug applicator
US5591123A (en) 1983-08-18 1997-01-07 Drug Delivery Systems Inc. Programmable control mounting system for transdermal drug applicator
US4695422A (en) 1984-02-16 1987-09-22 The Procter & Gamble Company Production of formed material by solid-state formation with a high-pressure liquid stream
US4583982A (en) 1984-08-24 1986-04-22 Vlock D G Fluid dispenser
US5569469A (en) 1984-10-16 1996-10-29 Vectorpharma International, S.P.A. Poorly soluble medicaments supported on polymer substances in a form suitable for increasing their dissolving rate
US5135477A (en) 1984-10-29 1992-08-04 Medtronic, Inc. Iontophoretic drug delivery
US4597961A (en) 1985-01-23 1986-07-01 Etscorn Frank T Transcutaneous application of nicotine
AU590872B2 (en) 1985-02-26 1989-11-23 Johns Hopkins University, The Neovascularization inhibitors and methods for their production and use
US4904475A (en) 1985-05-03 1990-02-27 Alza Corporation Transdermal delivery of drugs from an aqueous reservoir
US4609518A (en) 1985-05-31 1986-09-02 The Procter & Gamble Company Multi-phase process for debossing and perforating a polymeric web to coincide with the image of one or more three-dimensional forming structures
US4630603A (en) 1986-02-13 1986-12-23 The Kendall Company Wound dressing
US4743249A (en) 1986-02-14 1988-05-10 Ciba-Geigy Corp. Dermal and transdermal patches having a discontinuous pattern adhesive layer
AU597890B2 (en) 1986-03-14 1990-06-14 Drug Delivery Systems Inc. Transdermal drug applicator and electrodes therefor
US4660721A (en) 1986-04-07 1987-04-28 Cvp Systems, Inc. Sterilization package
US4784737A (en) 1986-04-18 1988-11-15 The United States Department Of Energy Electromicroinjection of particles into living cells
US4837049A (en) 1986-06-17 1989-06-06 Alfred E. Mann Foundation For Scientific Research Method of making an electrode array
US4743234A (en) 1987-05-18 1988-05-10 The Cloverline, Inc. Syringe magnifier
US4842794A (en) 1987-07-30 1989-06-27 Applied Extrusion Technologies, Inc. Method of making apertured films and net like fabrics
US5061258A (en) 1987-08-07 1991-10-29 Martz Joel D Vapor permeable dressing with releasable medication
US4846821A (en) 1987-08-24 1989-07-11 The Procter & Gamble Company Substantially fluid-impervious microbubbled polymeric web exhibiting low levels of noise when subjected to movement
DE3880763T2 (de) 1987-08-24 1993-12-02 Procter & Gamble Im wesentlichen flüssigkeitsundurchlässige polymere Warenbahn mit Mikrobläschen und Verfahren und Vorrichtung für deren Herstellung.
US4812305A (en) 1987-11-09 1989-03-14 Vocal Rodolfo S Well medicine strip
SU1641346A1 (ru) 1987-12-08 1991-04-15 Мгту Им.Н.Э.Баумана Устройство дл электростимул ции
DK157899C (da) 1987-12-15 1990-09-03 Coloplast As Hudpladeprodukt
FR2625937B1 (fr) 1988-01-19 1993-04-30 Vuillaume Andre Procede et dispositif pour perforer un produit en feuille, et produit perfore ainsi obtenu
US5362307A (en) 1989-01-24 1994-11-08 The Regents Of The University Of California Method for the iontophoretic non-invasive-determination of the in vivo concentration level of an inorganic or organic substance
US5198192A (en) 1988-05-18 1993-03-30 Inax Corporation Apparatus for detecting ingredient in urine, a toilet stool equipped with a urine detecting device and a room for urine detecting facility
US4894054A (en) 1988-06-20 1990-01-16 Miskinyar Shir A Preloaded automatic disposable syringe
JP2608921B2 (ja) 1988-06-27 1997-05-14 ティーディーケイ株式会社 高誘電率セラミックス組成物
GB2221394B (en) 1988-08-05 1992-03-04 Eilert Eilertsen An injection device
DE3844247A1 (de) 1988-12-29 1990-07-12 Minnesota Mining & Mfg Vorrichtung, insbesondere pflaster zum transdermalen verabreichen eines medikaments
SU1667864A1 (ru) 1989-03-23 1991-08-07 Опытный завод энергетического машиностроения Электростимул тор
US5134079A (en) 1989-03-27 1992-07-28 International Technidyne Corp. Fluid sample collection and delivery system and methods particularly adapted for body fluid sampling
US5788983A (en) 1989-04-03 1998-08-04 Rutgers, The State University Of New Jersey Transdermal controlled delivery of pharmaceuticals at variable dosage rates and processes
US5531675A (en) 1989-05-10 1996-07-02 Yoo; Tae W. Micro-acupuncture needle for a finger of a hand
CA2016900A1 (en) 1989-07-06 1991-01-06 Ronald J. Filipski Tines structure in clinical applicator
EP0429842B1 (en) 1989-10-27 1996-08-28 Korea Research Institute Of Chemical Technology Device for the transdermal administration of protein or peptide drug
US5215088A (en) 1989-11-07 1993-06-01 The University Of Utah Three-dimensional electrode device
JP2646766B2 (ja) 1989-11-08 1997-08-27 日本電気株式会社 皮膚角層の除去器具
US5190558A (en) 1989-11-08 1993-03-02 Nec Corporation Method of eliminating stratum corneum from the skin and an instrument to be used therefor
US5697901A (en) 1989-12-14 1997-12-16 Elof Eriksson Gene delivery by microneedle injection
US5244711A (en) 1990-03-12 1993-09-14 Mcneil-Ppc, Inc. Apertured non-woven fabric
US5162043A (en) 1990-03-30 1992-11-10 Alza Corporation Iontophoretic delivery device
US5139029A (en) 1990-04-06 1992-08-18 Henry Fishman Allergy testing apparatus and method
IT1246382B (it) 1990-04-17 1994-11-18 Eurand Int Metodo per la cessione mirata e controllata di farmaci nell'intestino e particolarmente nel colon
ATE129906T1 (de) 1990-07-19 1995-11-15 Nardino Righi Sicherheitsspritze zum einmaligen gebrauch.
TW279133B (cg-RX-API-DMAC7.html) 1990-12-13 1996-06-21 Elan Med Tech
US5279544A (en) 1990-12-13 1994-01-18 Sil Medics Ltd. Transdermal or interdermal drug delivery devices
US5156591A (en) 1990-12-13 1992-10-20 S. I. Scientific Innovations Ltd. Skin electrode construction and transdermal drug delivery device utilizing same
US5527288A (en) 1990-12-13 1996-06-18 Elan Medical Technologies Limited Intradermal drug delivery device and method for intradermal delivery of drugs
US5158073A (en) 1990-12-18 1992-10-27 Bukowski Voytek Z Acupressure foot massage mat
US5252279A (en) 1991-01-17 1993-10-12 Reinhold Industries Method for making perforated articles
US5312456A (en) 1991-01-31 1994-05-17 Carnegie Mellon University Micromechanical barb and method for making the same
US5160315A (en) 1991-04-05 1992-11-03 Minnesota Mining And Manufacturing Company Combined adhesive strip and transparent dressing delivery system
TW273531B (en) 1991-08-14 1996-04-01 Chicopee Textile-like apertured plastic films
JP3189337B2 (ja) 1991-11-08 2001-07-16 日本電気株式会社 皮膚角層の除去器具および除去方法
JPH05162076A (ja) 1991-12-13 1993-06-29 Sony Corp 遊離微粒子噴射加工装置
DE69230408T2 (de) 1992-02-18 2000-06-08 Mcneil-Ppc, Inc. Textilähnliche, gelochte plastikfolie
US5256360A (en) 1992-03-25 1993-10-26 Panasonic Technologies, Inc. Method of manufacturing a precision micro-filter
US5756117A (en) 1992-04-08 1998-05-26 International Medical Asscociates, Inc. Multidose transdermal drug delivery system
IE930532A1 (en) 1993-07-19 1995-01-25 Elan Med Tech Liquid material dispenser and valve
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5308625A (en) 1992-09-02 1994-05-03 Cygnus Therapeutic Systems Enhancement of transdermal drug delivery using monoalkyl phosphates and other absorption promoters
US5462743A (en) 1992-10-30 1995-10-31 Medipro Sciences Limited Substance transfer system for topical application
US5250067A (en) 1992-11-30 1993-10-05 Ala Gelfer Body treatment pad having a multiple number of sharpened skin-penetration protuberances
US5383512A (en) 1993-01-27 1995-01-24 Midwest Research Institute Method for fabricating a substrate having spaced apart microcapillaries thereon
JPH06238644A (ja) 1993-02-15 1994-08-30 Taiyo Yuden Co Ltd セラミックグリーンシートの加工方法
GB9305930D0 (en) 1993-03-22 1993-05-12 Moran Peter L Electrical circuit board
CN1222258C (zh) 1993-03-22 2005-10-12 美国3M公司 无窗的框架供给的敷料及其制备方法
US6685682B1 (en) 1993-03-22 2004-02-03 3M Innovative Properties Company Carrier delivered dressing and method of manufacture
IE68890B1 (en) 1993-04-08 1996-07-24 Elan Med Tech Intradermal delivery device
AU667766B2 (en) 1993-05-27 1996-04-04 Paul Hartmann Ag Hydrogel wound dressing product
US5330452A (en) 1993-06-01 1994-07-19 Zook Gerald P Topical medicating device
US5728089A (en) 1993-06-04 1998-03-17 The Regents Of The University Of California Microfabricated structure to be used in surgery
US5320600A (en) 1993-06-14 1994-06-14 Lambert Wm S Plural content container for simultaneous ejection
CA2132277C (en) 1993-10-22 2005-05-10 Giorgio Cirelli Injection device
JP3590805B2 (ja) 1993-11-10 2004-11-17 株式会社ニコン 採血装置
US5962011A (en) 1993-12-06 1999-10-05 Schering-Plough Healthcare Products, Inc. Device for delivery of dermatological ingredients
AU1848395A (en) 1994-02-22 1995-09-04 Board Of Trustees Of The University Of Illinois, The Genes and genetic elements associated with sensitivity to platinum-based drugs
US5457041A (en) 1994-03-25 1995-10-10 Science Applications International Corporation Needle array and method of introducing biological substances into living cells using the needle array
US5536263A (en) 1994-03-30 1996-07-16 Lectec Corporation Non-occulusive adhesive patch for applying medication to the skin
US5503843A (en) 1994-04-22 1996-04-02 Flora Inc. Transdermal delivery of alpha adrenoceptor blocking agents
KR0134152B1 (ko) 1994-05-23 1998-04-14 이형도 의약품 투여용 피부흠집 형성장치
KR0134151B1 (ko) 1994-05-23 1998-04-14 이형도 인슐린 패치
CA2149836C (en) 1994-05-23 1999-07-06 Sang Bae Choi Perforating device for dermal administration
CA2149943C (en) 1994-05-23 1999-07-13 Kwang Kyun Jang Skin perforating device for transdermal medication
US5851549A (en) 1994-05-25 1998-12-22 Becton Dickinson And Company Patch, with system and apparatus for manufacture
US5512219A (en) 1994-06-03 1996-04-30 Reflexite Corporation Method of casting a microstructure sheet having an array of prism elements using a reusable polycarbonate mold
US5591139A (en) 1994-06-06 1997-01-07 The Regents Of The University Of California IC-processed microneedles
US5487726A (en) 1994-06-16 1996-01-30 Ryder International Corporation Vaccine applicator system
US5771890A (en) 1994-06-24 1998-06-30 Cygnus, Inc. Device and method for sampling of substances using alternating polarity
US5496304A (en) 1994-07-20 1996-03-05 University Of Utah Research Foundation Surgical marking pen
US5498235A (en) 1994-09-30 1996-03-12 Becton Dickinson And Company Iontophoresis assembly including patch/controller attachment
US5551953A (en) 1994-10-31 1996-09-03 Alza Corporation Electrotransport system with remote telemetry link
IE72524B1 (en) 1994-11-04 1997-04-23 Elan Med Tech Analyte-controlled liquid delivery device and analyte monitor
US6120488A (en) 1994-11-28 2000-09-19 The Procter & Gamble Company Absorbent articles having cuffs and topsheet with skin care composition(s) disposed thereon
ATE177325T1 (de) 1994-12-09 1999-03-15 Novartis Erfind Verwalt Gmbh Transdermales system
WO1996037155A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical device and method for enhancing delivery of compounds through the skin
WO1996037256A1 (en) 1995-05-22 1996-11-28 Silicon Microdevices, Inc. Micromechanical patch for enhancing the delivery of compounds through the skin
US5869079A (en) 1995-06-02 1999-02-09 Oculex Pharmaceuticals, Inc. Formulation for controlled release of drugs by combining hydrophilic and hydrophobic agents
DE19525607A1 (de) 1995-07-14 1997-01-16 Boehringer Ingelheim Kg Transcorneales Arzneimittelfreigabesystem
US5780050A (en) 1995-07-20 1998-07-14 Theratech, Inc. Drug delivery compositions for improved stability of steroids
JP2713255B2 (ja) 1995-08-11 1998-02-16 日本電気株式会社 浸出液吸引装置
IE77523B1 (en) 1995-09-11 1997-12-17 Elan Med Tech Medicament delivery device
US5735273A (en) 1995-09-12 1998-04-07 Cygnus, Inc. Chemical signal-impermeable mask
JP2718408B2 (ja) 1995-09-20 1998-02-25 日本電気株式会社 浸出液吸引装置
US5645977A (en) 1995-09-22 1997-07-08 Industrial Technology Research Institute Method of making molds for manufacturing multiple-lead microstructures
US5658515A (en) 1995-09-25 1997-08-19 Lee; Abraham P. Polymer micromold and fabrication process
US5776103A (en) 1995-10-11 1998-07-07 Science Incorporated Fluid delivery device with bolus injection site
US5662127A (en) 1996-01-17 1997-09-02 Bio-Plas, Inc. Self-contained blood withdrawal apparatus and method
US5730721A (en) 1996-01-25 1998-03-24 Vesture Corporation Medical applicator and method
JP3430771B2 (ja) 1996-02-05 2003-07-28 株式会社デンソー 半導体力学量センサの製造方法
JPH09215755A (ja) 1996-02-09 1997-08-19 Poritoronikusu:Kk 皮接治療具
US5948488A (en) 1996-04-30 1999-09-07 3M Innovative Properties Company Glittering cube-corner article
US6219574B1 (en) 1996-06-18 2001-04-17 Alza Corporation Device and method for enchancing transdermal sampling
DE19624578A1 (de) 1996-06-20 1998-01-08 Nancy L Divers Vorrichtung zur Hautpflege
ATE241405T1 (de) 1996-07-03 2003-06-15 Altea Therapeutics Corp Mehrfache mechanische mikroperforierung von haut oder schleimhäuten
US6512010B1 (en) 1996-07-15 2003-01-28 Alza Corporation Formulations for the administration of fluoxetine
WO1998011937A1 (en) 1996-09-17 1998-03-26 Deka Products Limited Partnership System for delivery of drugs by transport
DE19649100A1 (de) 1996-11-27 1998-06-04 Lohmann Therapie Syst Lts Verfahren zur verlustarmen Herstellung wirkstoffhaltiger scheibenförmiger Formkörper und diese enthaltende transdermale therapeutische Systeme
WO1998028307A1 (en) 1996-12-23 1998-07-02 Sartomer Company, Inc. Free radically polymerizable silane monomers and oligomers and the method for making them
US5873849A (en) 1997-04-24 1999-02-23 Ichor Medical Systems, Inc. Electrodes and electrode arrays for generating electroporation inducing electrical fields
JP3097600B2 (ja) 1997-05-30 2000-10-10 日本電気株式会社 角質層穿刺装置
US5904712A (en) 1997-06-12 1999-05-18 Axelgaard Manufacturing Co., Ltd. Current-controlling electrode
US5928207A (en) 1997-06-30 1999-07-27 The Regents Of The University Of California Microneedle with isotropically etched tip, and method of fabricating such a device
US6216034B1 (en) 1997-08-01 2001-04-10 Genetronics, Inc. Method of programming an array of needle electrodes for electroporation therapy of tissue
US6241701B1 (en) 1997-08-01 2001-06-05 Genetronics, Inc. Apparatus for electroporation mediated delivery of drugs and genes
US6055453A (en) 1997-08-01 2000-04-25 Genetronics, Inc. Apparatus for addressing needle array electrodes for electroporation therapy
US6047208A (en) 1997-08-27 2000-04-04 Becton, Dickinson And Company Iontophoretic controller
US20010023324A1 (en) 1997-11-03 2001-09-20 Allan Pronovost Glucose detector and method for diagnosing diabetes
US5868244A (en) 1997-12-01 1999-02-09 Ethicon, Inc. Microbial barrier vented package for sterile medical devices and method of packaging
US5938684A (en) 1997-12-09 1999-08-17 Sierra Self Healing Products, Inc. Accupressure device for therapeutic relief
US6918901B1 (en) 1997-12-10 2005-07-19 Felix Theeuwes Device and method for enhancing transdermal agent flux
CA2313458C (en) 1997-12-11 2007-04-17 Alza Corporation Device for enhancing transdermal agent flux
EP1037686B1 (en) 1997-12-11 2005-08-17 Alza Corporation Device for enhancing transdermal agent flux
KR100557261B1 (ko) 1997-12-11 2006-03-07 알자 코포레이션 경피성 작용제 유동률을 증진시키기 위한 장치
US6135990A (en) 1997-12-17 2000-10-24 University Of South Florida Electroporation device and method
US6778853B1 (en) 1997-12-17 2004-08-17 University Of South Florida Electroporation device
ES2182379T3 (es) 1997-12-22 2003-03-01 Alza Corp Membrana de regulacion del regimen de liberacion para dispositivos de administracion controlada de farmacos.
US6024553A (en) 1997-12-22 2000-02-15 Mcneil-Ppc, Inc. Apparatus for supporting a starting web during formation of the apertured web
CA2575064C (en) 1997-12-31 2010-02-02 Medtronic Minimed, Inc. Insertion device for an insertion set and method of using the same
JPH11230707A (ja) 1998-02-10 1999-08-27 Mitsutoyo Corp マイクロセンサデバイスの製造方法
US6106751A (en) 1998-03-18 2000-08-22 The Regents Of The University Of California Method for fabricating needles via conformal deposition in two-piece molds
US6136008A (en) 1998-03-19 2000-10-24 3M Innovative Properties Company Skin abrader for biomedical electrode
US5902800A (en) 1998-03-27 1999-05-11 Glenpharma Dextran formulations and method for treatment of inflammatory joint disorders
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6120792A (en) 1998-04-29 2000-09-19 Juni; Jack E. Medicated skin patch and method for its use
US6290679B1 (en) 1999-05-14 2001-09-18 Disetronic Licensing Ag Device for metered administration of an injectable product
AU763433B2 (en) 1998-05-22 2003-07-24 California Institute Of Technology Microfabricated cell sorter
US6503231B1 (en) 1998-06-10 2003-01-07 Georgia Tech Research Corporation Microneedle device for transport of molecules across tissue
AU767122B2 (en) 1998-06-10 2003-10-30 Georgia Tech Research Corporation Microneedle devices and methods of manufacture and use thereof
GB9815819D0 (en) 1998-07-22 1998-09-16 Secr Defence Transferring materials into cells and a microneedle array
GB9815820D0 (en) 1998-07-22 1998-09-16 Secr Defence Improvements relating to micro-machining
US6532386B2 (en) 1998-08-31 2003-03-11 Johnson & Johnson Consumer Companies, Inc. Electrotransort device comprising blades
JP2000146777A (ja) 1998-09-08 2000-05-26 Matsushita Electric Ind Co Ltd 検体採取方法、検体採取装置、検体採取用容器、検体測定方法、検体測定装置および検体測定用容器
US7048723B1 (en) 1998-09-18 2006-05-23 The University Of Utah Research Foundation Surface micromachined microneedles
US6036659A (en) 1998-10-09 2000-03-14 Flexsite Diagnostics, Inc. Collection device for biological samples and methods of use
US6038465A (en) 1998-10-13 2000-03-14 Agilent Technologies, Inc. Telemedicine patient platform
US6611706B2 (en) 1998-11-09 2003-08-26 Transpharma Ltd. Monopolar and bipolar current application for transdermal drug delivery and analyte extraction
EP1003078A3 (en) 1998-11-17 2001-11-07 Corning Incorporated Replicating a nanoscale pattern
JP4214584B2 (ja) 1998-11-27 2009-01-28 株式会社デンソー 半導体力学量センサおよびその製造方法
CA2352974A1 (en) 1998-12-18 2000-06-22 John H. Livingston Insertion sets with micro-piercing members for use with medical devices and methods of using the same
JP2000194142A (ja) 1998-12-25 2000-07-14 Fujitsu Ltd パタ―ン形成方法及び半導体装置の製造方法
JP2000232095A (ja) 1999-02-12 2000-08-22 Nippon Telegr & Teleph Corp <Ntt> 半導体表面の微細パターン形成方法
JP2000232971A (ja) 1999-02-15 2000-08-29 Arkray Inc 吸引浸出液採取方法および装置
US5997549A (en) 1999-02-16 1999-12-07 Sauceda; Charles J. Wart removing tool
US6132449A (en) 1999-03-08 2000-10-17 Agilent Technologies, Inc. Extraction and transportation of blood for analysis
US6183770B1 (en) 1999-04-15 2001-02-06 Acutek International Carrier patch for the delivery of agents to the skin
US6689103B1 (en) 1999-05-07 2004-02-10 Scimed Life System, Inc. Injection array apparatus and method
JP2000323461A (ja) 1999-05-11 2000-11-24 Nec Corp 微細パターン形成装置、その製造方法、および形成方法
NO311797B1 (no) 1999-05-12 2002-01-28 Thin Film Electronics Asa Fremgangsmåter til mönstring av polymerfilmer og anvendelse av fremgangsmåtene
JP4114761B2 (ja) 1999-05-14 2008-07-09 国立大学法人群馬大学 情報記録ディスク用スタンパー、その製造方法、情報記録ディスク、および情報記録ディスク製造方法
CA2376128C (en) 1999-06-04 2009-01-06 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6743211B1 (en) 1999-11-23 2004-06-01 Georgia Tech Research Corporation Devices and methods for enhanced microneedle penetration of biological barriers
US6611707B1 (en) 1999-06-04 2003-08-26 Georgia Tech Research Corporation Microneedle drug delivery device
US6312612B1 (en) 1999-06-09 2001-11-06 The Procter & Gamble Company Apparatus and method for manufacturing an intracutaneous microneedle array
US6256533B1 (en) 1999-06-09 2001-07-03 The Procter & Gamble Company Apparatus and method for using an intracutaneous microneedle array
US6379324B1 (en) 1999-06-09 2002-04-30 The Procter & Gamble Company Intracutaneous microneedle array apparatus
DE19927359A1 (de) 1999-06-16 2000-12-21 Creavis Tech & Innovation Gmbh Elektrophoretische Displays aus lichtstreuenden Trägermaterialien
JP3654059B2 (ja) 1999-06-25 2005-06-02 松下電工株式会社 赤外線センサーの製造方法
ATE450895T1 (de) 1999-07-21 2009-12-15 E Ink Corp Bevorzugte methode, elektrische leiterbahnen für die kontrolle eines elektronischen displays herzustellen
JP3387897B2 (ja) 1999-08-30 2003-03-17 キヤノン株式会社 構造体の製造方法、並びに該製造方法により製造される構造体及び該構造体を用いた構造体デバイス
US6623457B1 (en) 1999-09-22 2003-09-23 Becton, Dickinson And Company Method and apparatus for the transdermal administration of a substance
US6835184B1 (en) 1999-09-24 2004-12-28 Becton, Dickinson And Company Method and device for abrading skin
US20030093089A1 (en) 1999-10-20 2003-05-15 Greenberg Ronald Allan Apparatus for variable micro abrasion of human tissue and/or hides using different size and types of abrasive particles
US6355054B1 (en) 1999-11-05 2002-03-12 Ceramoptec Industries, Inc. Laser system for improved transbarrier therapeutic radiation delivery
CN101238998A (zh) 1999-11-15 2008-08-13 维尔克工业有限公司 皮肤附着件
EP1233927A4 (en) 1999-11-17 2003-01-08 Univ California APPARATUS AND METHOD FOR FORMING A NANOMETRIC SCALE MEMBRANE
US6511463B1 (en) 1999-11-18 2003-01-28 Jds Uniphase Corporation Methods of fabricating microneedle arrays using sacrificial molds
US20010023351A1 (en) 1999-12-01 2001-09-20 Eilers George J. Skin abrasion system and method
HK1048773B (en) 1999-12-10 2005-10-14 Alza Corporation Skin treatment apparatus for sustained transdermal drug delivery
DK1239916T3 (da) 1999-12-10 2006-04-03 Alza Corp Indretning og fremgangsmåde til at forbedre perforering af hud med mikrofremspring
EP1239775B1 (en) 1999-12-16 2005-03-16 ALZA Corporation Device for enhancing transdermal flux of sampled agents
US6406638B1 (en) 2000-01-06 2002-06-18 The Regents Of The University Of California Method of forming vertical, hollow needles within a semiconductor substrate, and needles formed thereby
US6248120B1 (en) 2000-01-10 2001-06-19 P. Z. “HTL” Spolka Akcyjna Puncturing device
US6375627B1 (en) 2000-03-02 2002-04-23 Agilent Technologies, Inc. Physiological fluid extraction with rapid analysis
US6558361B1 (en) 2000-03-09 2003-05-06 Nanopass Ltd. Systems and methods for the transport of fluids through a biological barrier and production techniques for such systems
US6629949B1 (en) 2000-05-08 2003-10-07 Sterling Medivations, Inc. Micro infusion drug delivery device
US6565532B1 (en) 2000-07-12 2003-05-20 The Procter & Gamble Company Microneedle apparatus used for marking skin and for dispensing semi-permanent subcutaneous makeup
JP4001311B2 (ja) 2000-06-01 2007-10-31 株式会社リコー 液滴吐出ヘッド、インクジェット記録装置、マイクロアクチュエータ
US6537242B1 (en) 2000-06-06 2003-03-25 Becton, Dickinson And Company Method and apparatus for enhancing penetration of a member for the intradermal sampling or administration of a substance
US6607513B1 (en) 2000-06-08 2003-08-19 Becton, Dickinson And Company Device for withdrawing or administering a substance and method of manufacturing a device
JP2002000728A (ja) 2000-06-19 2002-01-08 Terumo Corp 微小針を備えた噴射式の薬液注入装置
US6494830B1 (en) 2000-06-22 2002-12-17 Guidance Interactive Technologies, Inc. Handheld controller for monitoring/using medical parameters
US6589202B1 (en) 2000-06-29 2003-07-08 Becton Dickinson And Company Method and apparatus for transdermally sampling or administering a substance to a patient
EP1299494B1 (en) 2000-07-07 2010-08-25 A.V. Topchiev Institute of Petrochemical Synthesis Preparation of hydrophilic pressure sensitive adhesives having optimized adhesive properties
US6603987B2 (en) 2000-07-11 2003-08-05 Bayer Corporation Hollow microneedle patch
US6440096B1 (en) 2000-07-14 2002-08-27 Becton, Dickinson And Co. Microdevice and method of manufacturing a microdevice
US6656147B1 (en) 2000-07-17 2003-12-02 Becton, Dickinson And Company Method and delivery device for the transdermal administration of a substance
US20080164638A1 (en) 2006-11-28 2008-07-10 Wei Zhang Method and apparatus for rapid imprint lithography
GB0017999D0 (en) 2000-07-21 2000-09-13 Smithkline Beecham Biolog Novel device
AU2000261716A1 (en) 2000-07-25 2002-02-05 Dickinson Legg Limited Lamina separator
US6533949B1 (en) 2000-08-28 2003-03-18 Nanopass Ltd. Microneedle structure and production method therefor
JP2002079499A (ja) 2000-09-08 2002-03-19 Terumo Corp 針形状物の作製方法および作製された針
CA2357386C (en) 2000-09-15 2009-03-24 Timberjack Inc. High rotation felling head mechanism
AU2001293460A1 (en) 2000-10-05 2002-04-15 Thomas Marsoner Medical injection device
US7419481B2 (en) 2000-10-13 2008-09-02 Alza Corporation Apparatus and method for piercing skin with microprotrusions
RU2275871C2 (ru) 2000-10-13 2006-05-10 Алза Корпорейшн Устройство и способ для прокалывания кожи микровыступами
HUP0303583A2 (en) 2000-10-13 2004-01-28 Alza Corp Microblade array impact applicator
KR20030068137A (ko) 2000-10-13 2003-08-19 알자 코포레이션 충격 어플리케이터용 미세 돌기 부재 리테이너
US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7131987B2 (en) 2000-10-16 2006-11-07 Corium International, Inc. Microstructures and method for treating and conditioning skin which cause less irritation during exfoliation
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
EP2085109A3 (en) 2000-10-26 2009-09-02 Alza Corporation Transdermal drug delivery devices having coated microprotrusions
US6533884B1 (en) 2000-11-03 2003-03-18 Printpack Illinois, Inc. Method and system for extrusion embossing
JP3525177B2 (ja) 2000-11-14 2004-05-10 関西ティー・エル・オー株式会社 X線を用いた材料の加工方法
US6591133B1 (en) 2000-11-27 2003-07-08 Microlin Llc Apparatus and methods for fluid delivery using electroactive needles and implantable electrochemical delivery devices
US9302903B2 (en) 2000-12-14 2016-04-05 Georgia Tech Research Corporation Microneedle devices and production thereof
US6508947B2 (en) 2001-01-24 2003-01-21 Xerox Corporation Method for fabricating a micro-electro-mechanical fluid ejector
WO2002062202A2 (en) 2001-02-05 2002-08-15 Becton, Dickinson And Company Microprotrusion array and methods of making a microprotrusion
JP3696513B2 (ja) 2001-02-19 2005-09-21 住友精密工業株式会社 針状体の製造方法
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
CN100349632C (zh) 2001-04-20 2007-11-21 阿尔扎公司 具有包含有益药剂的涂层的微小突出物阵列
US20020193729A1 (en) 2001-04-20 2002-12-19 Cormier Michel J.N. Microprojection array immunization patch and method
DE60233217D1 (de) 2001-05-01 2009-09-17 Corium Internat Inc Hydrogel-zusammensetzungen
US20050215727A1 (en) 2001-05-01 2005-09-29 Corium Water-absorbent adhesive compositions and associated methods of manufacture and use
US6585742B2 (en) 2001-05-08 2003-07-01 Dowling B. Stough Wart removal method and device
US6591124B2 (en) 2001-05-11 2003-07-08 The Procter & Gamble Company Portable interstitial fluid monitoring system
US6921410B2 (en) 2001-05-29 2005-07-26 Scimed Life Systems, Inc. Injection molded vaso-occlusive elements
US20020188310A1 (en) 2001-06-08 2002-12-12 Seward Kirk Partick Microfabricated surgical device
WO2002100476A2 (en) 2001-06-08 2002-12-19 Becton, Dickinson And Company Device for manipulating a needle or abrader array
US6767341B2 (en) 2001-06-13 2004-07-27 Abbott Laboratories Microneedles for minimally invasive drug delivery
WO2003000236A1 (en) 2001-06-23 2003-01-03 Lyotropic Therapeutics, Inc Particles with improved solubilization capacity
US20040204669A1 (en) 2001-07-05 2004-10-14 Hofmann Gunter A. Apparatus for electroporation mediated delivery for drugs and genes
US6749792B2 (en) 2001-07-09 2004-06-15 Lifescan, Inc. Micro-needles and methods of manufacture and use thereof
JP5055672B2 (ja) 2001-07-31 2012-10-24 大日本印刷株式会社 薄膜パターン形成用スタンプ
JP4919446B2 (ja) 2001-08-09 2012-04-18 学校法人東京電機大学 微細溝加工方法及びその装置
US6881203B2 (en) 2001-09-05 2005-04-19 3M Innovative Properties Company Microneedle arrays and methods of manufacturing the same
US20040087992A1 (en) 2002-08-09 2004-05-06 Vladimir Gartstein Microstructures for delivering a composition cutaneously to skin using rotatable structures
JP2005503210A (ja) 2001-09-14 2005-02-03 ザ プロクター アンド ギャンブル カンパニー 回転可能構造を用いて皮膚を介して組成物を皮膚に送達するための微細構造
EP1424928B1 (en) 2001-09-14 2019-09-11 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
WO2003024507A2 (en) 2001-09-19 2003-03-27 Biovalve Technologies, Inc. Microneedles, microneedle arrays, and systems and methods relating to same
US20030135201A1 (en) 2001-09-28 2003-07-17 Gonnelli Robert R. Microneedle with membrane
US7429258B2 (en) 2001-10-26 2008-09-30 Massachusetts Institute Of Technology Microneedle transport device
US20030093028A1 (en) 2001-11-09 2003-05-15 Michael Spiegel Appararus and method for magnetic induction of therapeutic electric fields
US20050208050A1 (en) 2001-11-09 2005-09-22 Gerd Multhaup Compounds for the diagnosis/prevention/treatment of alzheimer's disease
EP1485317A2 (en) 2001-11-30 2004-12-15 Alza Corporation Methods and apparatuses for forming microprojection arrays
JP4469610B2 (ja) 2002-02-04 2010-05-26 ベクトン・ディキンソン・アンド・カンパニー 皮膚アクセス部材
US6780171B2 (en) 2002-04-02 2004-08-24 Becton, Dickinson And Company Intradermal delivery device
US7115108B2 (en) 2002-04-02 2006-10-03 Becton, Dickinson And Company Method and device for intradermally delivering a substance
US7713214B2 (en) 2002-04-19 2010-05-11 Pelikan Technologies, Inc. Method and apparatus for a multi-use body fluid sampling device with optical analyte sensing
US6945952B2 (en) * 2002-06-25 2005-09-20 Theraject, Inc. Solid solution perforator for drug delivery and other applications
DK1534376T3 (en) 2002-06-25 2016-12-05 Theraject Inc QUICK-SOLVING MICROPERFORATORS FOR PHARMACEUTICAL DELIVERY AND OTHER APPLICATIONS
ATE336277T1 (de) 2002-06-28 2006-09-15 Alza Corp Verfahren zur oberflächenbeschichtung von vorrichtungen zur transdermalen verabreichung von arzneien mit beschichteten mikrovorsprüngen
CA2492867C (en) 2002-07-19 2011-07-05 3M Innovative Properties Company Microneedle devices and microneedle delivery apparatus
ATE421990T1 (de) 2002-07-22 2009-02-15 Meito Sangyo Kk Zusammensetzung zur förderung der vermehrung von lactobacillus casei subsp. casei
JP2004065775A (ja) 2002-08-08 2004-03-04 Sanwa Kagaku Kenkyusho Co Ltd 針状構造体を備えたデバイス
AR040819A1 (es) 2002-08-08 2005-04-20 Alza Corp Dispositivo de administracion transdermica de vacuna que tiene microproyecciones revestidas
US7166086B2 (en) 2002-08-29 2007-01-23 Becton, Dickinson And Company Substance delivery via a rotating microabrading surface
AU2003275311A1 (en) 2002-09-16 2004-04-30 Sung-Yun Kwon Solid micro-perforators and methods of use
US7148211B2 (en) 2002-09-18 2006-12-12 Genzyme Corporation Formulation for lipophilic agents
DE10244503A1 (de) 2002-09-25 2004-04-08 Capsulution Nanoscience Ag Methode zur Herstellung und Stabilisierung von Mikro- und Nanosuspensionen mit Amphiphilen und Polyelektrolyten
EP1590034B1 (en) 2002-10-07 2014-05-14 Biovalve Technologies, Inc. Microneedle array patch
GB0226401D0 (en) 2002-11-12 2002-12-18 Koninkl Philips Electronics Nv Electroluminescent devices and their manufacture
AR042815A1 (es) 2002-12-26 2005-07-06 Alza Corp Dispositivo de suministro de agente activo que tiene miembros compuestos
US7578954B2 (en) 2003-02-24 2009-08-25 Corium International, Inc. Method for manufacturing microstructures having multiple microelements with through-holes
US6926694B2 (en) 2003-05-09 2005-08-09 Medsolve Technologies, Llc Apparatus and method for delivery of therapeutic and/or diagnostic agents
US7572405B2 (en) 2003-06-02 2009-08-11 Corium International Inc. Method for manufacturing microstructures having hollow microelements using fluidic jets during a molding operation
CA2530520A1 (en) 2003-06-30 2005-01-20 Alza Corporation Method for coating skin piercing microprojections
CA2530954A1 (en) 2003-07-02 2005-01-13 Alza Corporation Microprojection array immunization patch and method
WO2005016441A1 (en) * 2003-08-04 2005-02-24 Alza Corporation Method and device for enhancing transdermal agent flux
US8353861B2 (en) 2003-09-18 2013-01-15 Texmac, Inc. Applicator for applying functional substances into human skin
EP1680057A4 (en) 2003-10-24 2007-10-31 Alza Corp DEVICE AND METHOD FOR IMPROVING TRANSDERMAL DRUG DELIVERY
BRPI0415629A (pt) 2003-10-31 2006-12-12 Alza Corp aplicador auto-atuador para conjunto de microprojeções
WO2005046769A2 (en) 2003-11-12 2005-05-26 Vidacare Corporation Reusable intraosseous device and method for accessing bone marrow in the sternum
CA2552385C (en) 2003-12-29 2013-07-23 3M Innovative Properties Company Medical devices and kits including same
AU2004313245B2 (en) 2003-12-30 2011-04-14 Durect Corporation Polymeric implants, preferably containing a mixture of PEG and PLG, for controlled release of active agents, preferably a GNRH
AT500095B8 (de) 2004-01-23 2007-02-15 Braun Werner Mag Transdermales abgabesystem
US8551391B2 (en) 2004-02-17 2013-10-08 Avery Dennison Corporation Method of making microneedles
US20070191761A1 (en) 2004-02-23 2007-08-16 3M Innovative Properties Company Method of molding for microneedle arrays
US20050203575A1 (en) 2004-03-15 2005-09-15 Unilever Home & Personal Care Usa, Division Of Conopco, Inc. Skin microactivation system and method
JP5085317B2 (ja) 2004-03-24 2012-11-28 コリウム インターナショナル, インコーポレイテッド 経皮送達デバイス
MXPA06011429A (es) 2004-04-01 2007-04-25 Johnson & Johnson Aparato y metodo para el suministro transdermico de la vacuna contra la influenza.
US20050271684A1 (en) 2004-04-13 2005-12-08 Trautman Joseph C Apparatus and method for transdermal delivery of multiple vaccines
US7556821B2 (en) * 2004-05-13 2009-07-07 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents
WO2005123173A1 (en) 2004-06-10 2005-12-29 3M Innovative Properties Company Patch application device and kit
WO2006015299A2 (en) 2004-07-30 2006-02-09 Microchips, Inc. Multi-reservoir device for transdermal drug delivery and sensing
TW200618830A (en) 2004-08-10 2006-06-16 Alza Corp Micorprojection apparatus and system with low infection potential
GB2417462A (en) 2004-08-31 2006-03-01 Eastman Chem Co Moulding of thermoplastic polyesters
CA2579471A1 (en) 2004-09-28 2006-04-06 Alza Corporation Stabilization of alum-adjuvanted immunologically active agents
US8267889B2 (en) 2004-11-18 2012-09-18 3M Innovative Properties Company Low-profile microneedle array applicator
US8057842B2 (en) 2004-11-18 2011-11-15 3M Innovative Properties Company Method of contact coating a microneedle array
KR101224257B1 (ko) 2004-11-18 2013-01-18 쓰리엠 이노베이티브 프로퍼티즈 컴파니 마이크로니들 어레이를 코팅하기 위한 마스킹 방법
US20080009811A1 (en) 2004-11-18 2008-01-10 3M Innovative Properties Company Non-Skin-Contacting Microneedle Array Applicator
JP4927752B2 (ja) 2004-11-18 2012-05-09 スリーエム イノベイティブ プロパティズ カンパニー マイクロニードルアレイアプリケーターおよび保持装置
ATE483493T1 (de) 2004-12-10 2010-10-15 3M Innovative Properties Co Medizinische vorrichtung
US20060134188A1 (en) 2004-12-20 2006-06-22 Hans-Peter Podhaisky Transdermal pharmaceutical preparation with a progesterone A-specific ligand (PRASL) as active ingredient
CA2595894C (en) 2005-01-31 2013-09-10 Kanji Takada Percutaneously absorbable preparation, percutaneously absorbable preparation holding sheet, and percutaneously absorbable preparation holding equipment
US20070043320A1 (en) 2005-02-09 2007-02-22 Kenany Saad A Microstream injector
WO2006101459A1 (en) 2005-03-23 2006-09-28 Agency For Science, Technology And Research Microneedles
JP2006271781A (ja) 2005-03-30 2006-10-12 Toppan Printing Co Ltd 医療品用滅菌包装袋の製造方法
EP1871459B1 (en) 2005-04-07 2019-06-19 3M Innovative Properties Company System for tool feedback sensing
US20060253078A1 (en) 2005-04-25 2006-11-09 Wu Jeffrey M Method of treating skin disorders with stratum corneum piercing device
JP2006341089A (ja) 2005-05-13 2006-12-21 Fujikura Ltd 医薬物運搬用器具およびその製造方法
WO2007002523A2 (en) 2005-06-24 2007-01-04 3M Innovative Properties Company Collapsible patch with microneedle array
CN101208129B (zh) 2005-06-27 2011-03-30 3M创新有限公司 微针药筒组件及其施放方法
WO2007002521A2 (en) 2005-06-27 2007-01-04 3M Innovative Properties Company Microneedle array applicator device
CN101227940A (zh) 2005-07-25 2008-07-23 纳米技术维多利亚有限公司 微阵列装置
US20070078414A1 (en) 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
CA2629393C (en) * 2005-09-06 2014-06-10 Theraject, Inc. Solid solution perforator containing drug particle and/or drug-adsorbed particles
EP2368573A3 (en) 2005-11-04 2013-05-01 Novartis Vaccines and Diagnostics S.r.l. Influenza vaccines including combinations of particulate adjuvants and immunopotentiators
JP2007130030A (ja) 2005-11-08 2007-05-31 Toray Ind Inc マイクロニードル、マイクロニードル集合体及びその製造方法
WO2007061964A1 (en) 2005-11-18 2007-05-31 3M Innovative Properties Company Methods for coating microneedles
US7842008B2 (en) 2005-11-21 2010-11-30 Becton, Dickinson And Company Intradermal delivery device
EP1968777B1 (en) 2005-12-23 2013-11-06 3M Innovative Properties Company Manufacturing microneedle arrays
US7658728B2 (en) 2006-01-10 2010-02-09 Yuzhakov Vadim V Microneedle array, patch, and applicator for transdermal drug delivery
JP2007190112A (ja) 2006-01-18 2007-08-02 Toray Ind Inc マイクロニードル
JP2009529400A (ja) 2006-03-10 2009-08-20 アルザ コーポレイション 高バリア保持具を備えた微小突起アレイの適用
CA2680690A1 (en) * 2006-03-15 2007-09-20 Alza Corporation Apparatus and method for transdermal delivery of parathyroid hormone agents to prevent or treat osteopenia
US9119945B2 (en) 2006-04-20 2015-09-01 3M Innovative Properties Company Device for applying a microneedle array
WO2008024141A2 (en) * 2006-05-09 2008-02-28 Apogee Technology, Inc. Nanofiber structures on asperities for sequestering, carrying and transferring substances
US20080063866A1 (en) 2006-05-26 2008-03-13 Georgia Tech Research Corporation Method for Making Electrically Conductive Three-Dimensional Structures
JP2008006178A (ja) 2006-06-30 2008-01-17 Fujifilm Corp マイクロニードルシートの製造方法及び製造装置
US20090182306A1 (en) 2006-07-21 2009-07-16 Georgia Tech Research Corporation Microneedle Devices and Methods of Drug Delivery or Fluid Withdrawal
WO2008011625A2 (en) 2006-07-21 2008-01-24 Georgia Tech Researh Corporation Microneedle devices and methods of drug delivery or fluid withdrawal
WO2008013282A1 (fr) 2006-07-27 2008-01-31 Toppan Printing Co., Ltd. Procédé de production d'une micro-aiguille
ITMI20061538A1 (it) 2006-08-02 2008-02-03 Mediolanum Pharmaceuticals Ltd Impianti sottocutanei in grado di rilasciare il principio attivo per un periodo prolungato di tempo
JPWO2008020633A1 (ja) 2006-08-18 2010-01-07 凸版印刷株式会社 マイクロニードル及びマイクロニードルパッチ
CN101505816B (zh) 2006-08-24 2012-05-30 霍夫曼-拉罗奇有限公司 适于插入头部尤其是适于插入输注装置的插入工具
JP4925039B2 (ja) 2006-09-21 2012-04-25 日東電工株式会社 糖材料の調製方法ならびに糖材料、糖材料を含むマイクロニードルおよびマイクロニードルをそなえてなる経皮製剤
US20110165236A1 (en) 2006-09-22 2011-07-07 Biokey, Inc. Controlled release hydrogel formulation
JPWO2008062832A1 (ja) 2006-11-22 2010-03-04 凸版印刷株式会社 マイクロニードルアレイ及びマイクロニードルアレイの製造方法
US7785301B2 (en) 2006-11-28 2010-08-31 Vadim V Yuzhakov Tissue conforming microneedle array and patch for transdermal drug delivery or biological fluid collection
JP2008142183A (ja) 2006-12-07 2008-06-26 Fujifilm Corp マイクロニードルシート及びその製造方法
US20080214987A1 (en) 2006-12-22 2008-09-04 Nanomed Devices, Inc. Microdevice And Method For Transdermal Delivery And Sampling Of Active Substances
WO2008091602A2 (en) 2007-01-22 2008-07-31 Corium International, Inc. Applicators for microneedle arrays
CN101594905A (zh) 2007-01-29 2009-12-02 株式会社医药处方 生产热敏物质微针的方法
JP4959363B2 (ja) 2007-02-14 2012-06-20 凸版印刷株式会社 針状体の製造方法
AU2008241470B2 (en) * 2007-04-16 2013-11-07 Corium Pharma Solutions, Inc. Solvent-cast microneedle arrays containing active
US7578985B2 (en) 2007-04-18 2009-08-25 Gas Technology Institute Method for direct oxidation of hydrogen sulfide to elemental sulfur at low temperatures
US20080269665A1 (en) 2007-04-24 2008-10-30 Johan Petersen Chemotherapy delivery device
EP2153863B1 (en) 2007-05-15 2022-03-16 Hisamitsu Pharmaceutical Co., Inc. Method of coating microneedle
JP2008284318A (ja) 2007-05-15 2008-11-27 Kosumedei Seiyaku Kk 生体由来物質からなる投薬用微細針
WO2008150970A2 (en) 2007-05-30 2008-12-11 Dow Global Technologies Inc. High-output solvent-based electrospinning
US20090041810A1 (en) 2007-07-09 2009-02-12 Andrianov Alexander K Immunostimulating polyphosphazene compounds for intradermal immunization
US20090017210A1 (en) * 2007-07-09 2009-01-15 Andrianov Alexander K Methods and systems for coating a microneedle with a dosage of a biologically active compound
WO2009012601A1 (en) 2007-07-26 2009-01-29 Sanofi Pasteur Limited Antigen-adjuvant compositions and methods
US20120150023A1 (en) 2007-08-06 2012-06-14 Kaspar Roger L Microneedle arrays for active agent delivery
US8366677B2 (en) 2007-08-06 2013-02-05 Transderm, Inc. Microneedle arrays formed from polymer films
US8409145B2 (en) 2007-09-17 2013-04-02 Tecpharma Licensing Ag Insertion devices for infusion devices
JP4885816B2 (ja) 2007-09-27 2012-02-29 富士フイルム株式会社 機能性膜の製造方法および製造装置
JP2009082206A (ja) 2007-09-27 2009-04-23 Fujifilm Corp 機能性膜の製造方法
ES2612061T3 (es) 2007-09-28 2017-05-11 The Queen's University Of Belfast Dispositivo y método de suministro
WO2009048607A1 (en) 2007-10-10 2009-04-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US20090117158A1 (en) 2007-10-23 2009-05-07 Mahmoud Ameri Transdermal sustained release drug delivery
CN101868229A (zh) 2007-11-21 2010-10-20 株式会社培旺精廉宅 体表适用制剂和体表适用制剂保持片
US9220678B2 (en) 2007-12-24 2015-12-29 The University Of Queensland Coating method
JP5267910B2 (ja) 2008-02-28 2013-08-21 コスメディ製薬株式会社 マイクロニードルアレイ
JP5584202B2 (ja) 2008-05-21 2014-09-03 セラジェクト, インコーポレイテッド 固溶体穿孔器パッチの製造方法及びその使用
AU2009250341A1 (en) 2008-05-23 2009-11-26 The University Of Queensland Analyte detection using a needle projection patch
KR20100037389A (ko) 2008-10-01 2010-04-09 연세대학교 산학협력단 다중 약물방출조절이 가능한 솔리드 마이크로구조체 및 이의 제조방법
WO2010040271A1 (en) * 2008-10-07 2010-04-15 Tuo Jin Phase-transition polymeric microneedles
CN102333565A (zh) 2008-10-16 2012-01-25 昆士兰大学 用于涂布帖剂组件上的突起物的方法和相关的装置
KR20100064669A (ko) 2008-12-05 2010-06-15 폴 곽 마이크로 니들 피부 미용기
US8734697B2 (en) 2008-12-22 2014-05-27 The University Of Queensland Patch production
KR101634836B1 (ko) 2008-12-26 2016-06-29 히사미쓰 세이야꾸 가부시키가이샤 마이크로 니들 디바이스
JP2010233673A (ja) 2009-03-30 2010-10-21 Fujifilm Corp 経皮吸収シート及びその製造方法
JP2010233674A (ja) 2009-03-30 2010-10-21 Fujifilm Corp マイクロニードルシート及びその使用方法並びに製造方法
ES2634667T3 (es) 2009-04-24 2017-09-28 Corium International, Inc. Métodos para fabricar conjuntos de microproyección
JP2011012050A (ja) 2009-06-03 2011-01-20 Bioserentack Co Ltd 多孔性基盤を用いたマイクロニードル・アレイとその製造方法
ES2691259T3 (es) 2009-06-10 2018-11-26 Hisamitsu Pharmaceutical Co., Inc. Dispositivo de microagujas
RU2414255C1 (ru) 2009-07-01 2011-03-20 Институт теоретической и прикладной механики им. С.А. Христиановича СО РАН (ИТПМ СО РАН) Способ введения жидкого вещества в микрокапсулы и устройство для его осуществления
KR101686692B1 (ko) 2009-07-23 2016-12-14 히사미쓰 세이야꾸 가부시키가이샤 마이크로니들 어레이
RU2508135C2 (ru) 2009-07-31 2014-02-27 3М Инновейтив Пропертиз Компани Матрица полых микроигл
US8834423B2 (en) 2009-10-23 2014-09-16 University of Pittsburgh—of the Commonwealth System of Higher Education Dissolvable microneedle arrays for transdermal delivery to human skin
DK2327433T3 (da) 2009-11-26 2012-07-23 Hoffmann La Roche Udefra udløselig kanyleanordning
WO2011105496A1 (ja) 2010-02-24 2011-09-01 久光製薬株式会社 マイクロニードルデバイス
US20110306853A1 (en) 2010-03-19 2011-12-15 Michael Darryl Black Body fluid sampling/fluid delivery device
WO2011121023A1 (en) 2010-03-30 2011-10-06 Unomedical A/S Medical device
WO2012046149A1 (en) 2010-04-28 2012-04-12 Kimberly-Clark Worldwide, Inc. Method for increasing permeability of an epithelial barrier
WO2011140274A2 (en) 2010-05-04 2011-11-10 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
AU2011248166B2 (en) 2010-05-04 2015-12-17 Corium Pharma Solutions, Inc. Applicators for microneedles
UY33386A (es) 2010-05-14 2011-12-30 Abbott Laboratoires Proteínas de unión a il-1
EP2399624B1 (en) 2010-06-21 2015-10-07 F.Hoffmann-La Roche Ag Device for inserting a soft member into the tissue of the body of a patient
CA2808965C (en) 2010-08-20 2020-01-07 Novartis Ag Soluble needle arrays for delivery of influenza vaccines
US8703727B2 (en) 2010-08-24 2014-04-22 Aphios Corporation Nanotechnology formulation of poorly soluble compounds
JP5937092B2 (ja) 2010-10-19 2016-06-22 トラスティーズ オブ タフツ カレッジ シルクフィブロインベースのマイクロニードルおよびその製造方法
EP2637562B1 (en) 2010-11-09 2016-01-27 Seventh Sense Biosystems, Inc. Systems and interfaces for blood sampling
CN102000020B (zh) 2010-11-17 2012-10-10 河南羚锐制药股份有限公司北京药物研究院 新型可降解聚合物微针贴剂及其制备方法
CA2822428A1 (en) 2010-12-22 2012-06-28 Valeritas, Inc. Microneedle patch applicator
KR20140041438A (ko) 2011-01-24 2014-04-04 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘, 엘티디. 약물의 진피 및 전신 전달을 위한 나노입자
DK2683359T3 (en) 2011-03-07 2015-07-20 3M Innovative Properties Co MICROWAVE DEVICES AND METHODS
GB2486748B (en) 2011-03-24 2013-04-10 Owen Mumford Ltd Autoinjector devices
GB201107642D0 (en) 2011-05-09 2011-06-22 Univ Cork Method
EP3881781B1 (en) 2011-10-12 2023-03-29 Vaxxas Pty Limited Delivery device
US9675675B2 (en) 2011-11-30 2017-06-13 3M Innovative Properties Company Microneedle device having a peptide therapeutic agent and an amino acid, methods of making and using the same
SMT202200355T1 (it) 2011-12-16 2022-11-18 Modernatx Inc Composizioni di mrna modificato
CN102580232B (zh) 2012-02-23 2013-12-18 游学秋 一种丝素微针系统和丝素纳米颗粒及其制备方法
US8765725B2 (en) 2012-05-08 2014-07-01 Aciex Therapeutics, Inc. Preparations of hydrophobic therapeutic agents, methods of manufacture and use thereof
WO2013172999A1 (en) 2012-05-16 2013-11-21 Mewa Singh Pharmaceutical compositions for the delivery of substantially water-insoluble drugs
US20140200508A1 (en) 2012-06-29 2014-07-17 Isaac D. Cohen Microneedles Comprising One Or More Cosmetic Ingredients
CN104755128B (zh) 2012-11-02 2018-05-11 考司美德制药株式会社 视黄酸微针
CN104780967B (zh) 2012-11-13 2017-04-12 富士胶片株式会社 经皮吸收片的制造方法
JP5980347B2 (ja) 2012-11-13 2016-08-31 富士フイルム株式会社 経皮吸収シートの製造方法
AU2013352155B2 (en) 2012-11-29 2016-06-16 Massachusetts Institute Of Technology Adhesive articles containing a combination of surface micropatterning and reactive chemistry and methods of making and using thereof
KR102265808B1 (ko) 2012-12-21 2021-06-16 코리움, 인크. 치료제의 전달을 위한 마이크로어레이 및 그것의 사용방법
CN104027324B (zh) 2013-03-06 2017-12-15 中国科学院理化技术研究所 一种可溶性微针疫苗贴片及其制备方法
EP2974768A4 (en) 2013-03-12 2017-05-17 Takeda Pharmaceutical Company Limited Micro-needle patch
EP2968887B1 (en) 2013-03-12 2022-05-04 Corium, Inc. Microprojection applicators
EP4194028A1 (en) 2013-03-15 2023-06-14 Corium Pharma Solutions, Inc. Multiple impact microprojection applicators
EP2968116A1 (en) 2013-03-15 2016-01-20 Corium International, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
MX2015012433A (es) 2013-03-15 2016-02-03 Corium Int Inc Matriz de microestructura para suministro de agentes activos.
CN105246458B (zh) 2013-03-15 2020-09-15 考里安公司 用于治疗剂递送的微阵列及其使用方法
JP2016512754A (ja) 2013-03-15 2016-05-09 コリウム インターナショナル, インコーポレイテッド 治療剤の送達のためのマイクロアレイ、使用方法および製造方法
US10369340B2 (en) 2013-08-12 2019-08-06 Nanomedical Systems, Inc. Device and method for sustained release of low water solubility therapeutic agent in solubilizer
JP6934721B2 (ja) 2014-04-24 2021-09-15 ジョージア テック リサーチ コーポレイション マイクロニードル及びその製造方法
EP3193828B8 (en) 2014-08-29 2023-04-05 Corium Pharma Solutions, Inc. Microstructure array for delivery of active agents
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
JP5931155B2 (ja) 2014-09-30 2016-06-08 日本写真印刷株式会社 マイクロニードルシートの梱包体及びその製造方法
CA2967028A1 (en) 2014-11-07 2016-05-12 Corium International, Inc. Medical device packaging
WO2016149152A1 (en) 2015-03-13 2016-09-22 The University Of North Carolina At Chapel Hill Polymeric microneedles and rapid additive manufacturing of the same
WO2017004067A1 (en) 2015-06-29 2017-01-05 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
US11285308B2 (en) 2015-12-28 2022-03-29 Endoderma Co., Ltd. Microstructure for transdermal absorption and method for manufacturing same

Similar Documents

Publication Publication Date Title
JP2013527853A5 (cg-RX-API-DMAC7.html)
Kim et al. Microneedles for drug and vaccine delivery
US20250262390A1 (en) Applicator for applying a microneedle device to skin
Bal et al. Advances in transcutaneous vaccine delivery: do all ways lead to Rome?
US10391290B2 (en) Microneedle injection apparatus comprising a dual cover
Ye et al. Polymeric microneedles for transdermal protein delivery
US9782574B2 (en) Force-controlled applicator for applying a microneedle device to skin
CN105073180B (zh) 包括计数器组件的微针施用装置
ES2921481T3 (es) Aplicadores para microproyecciones
JP2011172968A5 (cg-RX-API-DMAC7.html)
US10300260B2 (en) Applicator and method for applying a microneedle device to skin
ES2786508T3 (es) Lámina de microagujas
MX2015012433A (es) Matriz de microestructura para suministro de agentes activos.
WO2011140274A3 (en) Method and device for transdermal delivery of parathyroid hormone using a microprojection array
TW200526286A (en) System and method for transdermal delivery
CN101252967A (zh) 用于涂布微凸起构件的连续条带的方法和装置
WO2014036556A3 (en) Drug delivery systems and methods for treatment of prostate disease comprising gemicitabine
US20190381295A1 (en) Portable transdermal administration patch apparatus and preparation method thereof
KR20070099540A (ko) 향상된 피부 점착성 및 순응도를 갖는 미세돌출부 어레이
Lallow Intradermal Platforms for the Delivery of Nucleic Acid-Based Vaccines in Vivo
CN202590086U (zh) 胰岛素注射定位装置
CN201735027U (zh) 胰岛素注射辅助装置
김낙원 et al. Efficient DNA vaccination by introducing chemotatic peptide loaded microspheres and polyplexs with multi-layered
Lee et al. Micro needle array fabrication for drug delivery and drug delivery evaluation test using optical inspection module
CN202397911U (zh) 胰岛素注射定位腰带