JP2011517560A5 - - Google Patents
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- JP2011517560A5 JP2011517560A5 JP2011500906A JP2011500906A JP2011517560A5 JP 2011517560 A5 JP2011517560 A5 JP 2011517560A5 JP 2011500906 A JP2011500906 A JP 2011500906A JP 2011500906 A JP2011500906 A JP 2011500906A JP 2011517560 A5 JP2011517560 A5 JP 2011517560A5
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- Prior art keywords
- polypeptide
- inhibitor
- cell
- pluripotent
- cells
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 131
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 130
- 229920001184 polypeptide Polymers 0.000 claims description 128
- 210000004027 cell Anatomy 0.000 claims description 110
- 238000000034 method Methods 0.000 claims description 72
- 239000003112 inhibitor Substances 0.000 claims description 38
- 239000003795 chemical substances by application Substances 0.000 claims description 37
- 239000000203 mixture Substances 0.000 claims description 26
- 230000011987 methylation Effects 0.000 claims description 23
- 238000007069 methylation reaction Methods 0.000 claims description 23
- 210000000130 stem cell Anatomy 0.000 claims description 15
- 229940124647 MEK inhibitor Drugs 0.000 claims description 14
- 239000002829 mitogen activated protein kinase inhibitor Substances 0.000 claims description 14
- 210000001778 pluripotent stem cell Anatomy 0.000 claims description 13
- 239000012824 ERK inhibitor Substances 0.000 claims description 12
- 102000001267 GSK3 Human genes 0.000 claims description 12
- 108060006662 GSK3 Proteins 0.000 claims description 12
- 102000016397 Methyltransferase Human genes 0.000 claims description 12
- 108060004795 Methyltransferase Proteins 0.000 claims description 12
- 108020005497 Nuclear hormone receptor Proteins 0.000 claims description 12
- 108091005735 TGF-beta receptors Proteins 0.000 claims description 12
- 102000016715 Transforming Growth Factor beta Receptors Human genes 0.000 claims description 12
- 239000012190 activator Substances 0.000 claims description 12
- 239000000556 agonist Substances 0.000 claims description 12
- 229940121372 histone deacetylase inhibitor Drugs 0.000 claims description 12
- 239000003276 histone deacetylase inhibitor Substances 0.000 claims description 12
- 239000003446 ligand Substances 0.000 claims description 12
- NFVJNJQRWPQVOA-UHFFFAOYSA-N n-[2-chloro-5-(trifluoromethyl)phenyl]-2-[3-(4-ethyl-5-ethylsulfanyl-1,2,4-triazol-3-yl)piperidin-1-yl]acetamide Chemical compound CCN1C(SCC)=NN=C1C1CN(CC(=O)NC=2C(=CC=C(C=2)C(F)(F)F)Cl)CCC1 NFVJNJQRWPQVOA-UHFFFAOYSA-N 0.000 claims description 12
- 102000006255 nuclear receptors Human genes 0.000 claims description 12
- 108020004017 nuclear receptors Proteins 0.000 claims description 12
- 230000037361 pathway Effects 0.000 claims description 12
- 230000017858 demethylation Effects 0.000 claims description 11
- 238000010520 demethylation reaction Methods 0.000 claims description 11
- 210000004962 mammalian cell Anatomy 0.000 claims description 11
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims description 10
- 238000012216 screening Methods 0.000 claims description 6
- 238000000338 in vitro Methods 0.000 claims description 5
- 230000032459 dedifferentiation Effects 0.000 claims description 3
- 230000008672 reprogramming Effects 0.000 claims description 3
- 102000007665 Extracellular Signal-Regulated MAP Kinases Human genes 0.000 claims description 2
- 102000043136 MAP kinase family Human genes 0.000 claims description 2
- 108091054455 MAP kinase family Proteins 0.000 claims description 2
- 230000007348 cell dedifferentiation Effects 0.000 claims description 2
- 230000018109 developmental process Effects 0.000 claims description 2
- 210000001082 somatic cell Anatomy 0.000 claims description 2
- 230000004663 cell proliferation Effects 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000013598 vector Substances 0.000 description 25
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 108020004414 DNA Proteins 0.000 description 8
- 108091033319 polynucleotide Proteins 0.000 description 8
- 102000040430 polynucleotide Human genes 0.000 description 8
- 239000002157 polynucleotide Substances 0.000 description 8
- 102100035423 POU domain, class 5, transcription factor 1 Human genes 0.000 description 7
- 101710126211 POU domain, class 5, transcription factor 1 Proteins 0.000 description 7
- 239000013604 expression vector Substances 0.000 description 7
- 239000013600 plasmid vector Substances 0.000 description 7
- 230000001177 retroviral effect Effects 0.000 description 7
- 230000003612 virological effect Effects 0.000 description 7
- 108700021430 Kruppel-Like Factor 4 Proteins 0.000 description 5
- 101710135898 Myc proto-oncogene protein Proteins 0.000 description 5
- 102100038895 Myc proto-oncogene protein Human genes 0.000 description 5
- 101100247004 Rattus norvegicus Qsox1 gene Proteins 0.000 description 5
- 101710150448 Transcriptional regulator Myc Proteins 0.000 description 5
- 241001465754 Metazoa Species 0.000 description 4
- 210000005260 human cell Anatomy 0.000 description 4
- 238000003259 recombinant expression Methods 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 3
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 3
- 239000013543 active substance Substances 0.000 description 3
- 210000002744 extracellular matrix Anatomy 0.000 description 3
- 210000003780 hair follicle Anatomy 0.000 description 3
- 230000001939 inductive effect Effects 0.000 description 3
- 210000005155 neural progenitor cell Anatomy 0.000 description 3
- 210000003491 skin Anatomy 0.000 description 3
- OSXFATOLZGZLSK-UHFFFAOYSA-N 6,7-dimethoxy-2-(4-methyl-1,4-diazepan-1-yl)-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine Chemical compound C=12C=C(OC)C(OC)=CC2=NC(N2CCN(C)CCC2)=NC=1NC(CC1)CCN1CC1=CC=CC=C1 OSXFATOLZGZLSK-UHFFFAOYSA-N 0.000 description 2
- 210000002950 fibroblast Anatomy 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010067306 Fibronectins Proteins 0.000 description 1
- 102000016359 Fibronectins Human genes 0.000 description 1
- 108010085895 Laminin Proteins 0.000 description 1
- 102000007547 Laminin Human genes 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 108010082117 matrigel Proteins 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6995608P | 2008-03-17 | 2008-03-17 | |
| US61/069,956 | 2008-03-17 | ||
| US19798608P | 2008-10-31 | 2008-10-31 | |
| US61/197,986 | 2008-10-31 | ||
| PCT/US2009/037429 WO2009117439A2 (en) | 2008-03-17 | 2009-03-17 | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015013821A Division JP2015119714A (ja) | 2008-03-17 | 2015-01-28 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011517560A JP2011517560A (ja) | 2011-06-16 |
| JP2011517560A5 true JP2011517560A5 (enExample) | 2012-05-24 |
| JP5951254B2 JP5951254B2 (ja) | 2016-07-13 |
Family
ID=41091504
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011500906A Active JP5951254B2 (ja) | 2008-03-17 | 2009-03-17 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| JP2015013821A Pending JP2015119714A (ja) | 2008-03-17 | 2015-01-28 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| JP2016151681A Active JP6321733B2 (ja) | 2008-03-17 | 2016-08-02 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| JP2018072807A Active JP6899792B2 (ja) | 2008-03-17 | 2018-04-05 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| JP2021099098A Active JP7286710B2 (ja) | 2008-03-17 | 2021-06-15 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| JP2023085020A Active JP7642712B2 (ja) | 2008-03-17 | 2023-05-24 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| JP2024198599A Pending JP2025015628A (ja) | 2008-03-17 | 2024-11-13 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015013821A Pending JP2015119714A (ja) | 2008-03-17 | 2015-01-28 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| JP2016151681A Active JP6321733B2 (ja) | 2008-03-17 | 2016-08-02 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| JP2018072807A Active JP6899792B2 (ja) | 2008-03-17 | 2018-04-05 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| JP2021099098A Active JP7286710B2 (ja) | 2008-03-17 | 2021-06-15 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| JP2023085020A Active JP7642712B2 (ja) | 2008-03-17 | 2023-05-24 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| JP2024198599A Pending JP2025015628A (ja) | 2008-03-17 | 2024-11-13 | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
Country Status (15)
| Country | Link |
|---|---|
| US (8) | US9534205B2 (enExample) |
| EP (4) | EP2279243B1 (enExample) |
| JP (7) | JP5951254B2 (enExample) |
| KR (1) | KR101679082B1 (enExample) |
| CN (2) | CN104694570B (enExample) |
| AU (1) | AU2009225665B9 (enExample) |
| BR (1) | BRPI0908708A2 (enExample) |
| CA (1) | CA2718904C (enExample) |
| ES (1) | ES2690554T3 (enExample) |
| IL (1) | IL208144B (enExample) |
| MX (1) | MX2010010165A (enExample) |
| RU (1) | RU2010139426A (enExample) |
| SG (4) | SG10201607710UA (enExample) |
| WO (1) | WO2009117439A2 (enExample) |
| ZA (1) | ZA201006683B (enExample) |
Families Citing this family (184)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US20110171185A1 (en) * | 1999-06-30 | 2011-07-14 | Klimanskaya Irina V | Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof |
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| AU2006304392B2 (en) | 2005-10-18 | 2014-05-01 | National Jewish Health | Conditionally immortalized long-term stem cells and methods of making and using such cells |
| US8278104B2 (en) * | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
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| US20090227032A1 (en) * | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| CN105861443A (zh) | 2007-04-07 | 2016-08-17 | 怀特黑德生物医学研究所 | 体细胞重编程 |
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