ZA201006683B - Combined chemical and genetic approaches for generation of induced pluripotent stem cells - Google Patents
Combined chemical and genetic approaches for generation of induced pluripotent stem cellsInfo
- Publication number
- ZA201006683B ZA201006683B ZA2010/06683A ZA201006683A ZA201006683B ZA 201006683 B ZA201006683 B ZA 201006683B ZA 2010/06683 A ZA2010/06683 A ZA 2010/06683A ZA 201006683 A ZA201006683 A ZA 201006683A ZA 201006683 B ZA201006683 B ZA 201006683B
- Authority
- ZA
- South Africa
- Prior art keywords
- generation
- stem cells
- pluripotent stem
- induced pluripotent
- genetic approaches
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0618—Cells of the nervous system
- C12N5/0623—Stem cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
- C12N5/0656—Adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2500/00—Specific components of cell culture medium
- C12N2500/05—Inorganic components
- C12N2500/10—Metals; Metal chelators
- C12N2500/12—Light metals, i.e. alkali, alkaline earth, Be, Al, Mg
- C12N2500/14—Calcium; Ca chelators; Calcitonin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/01—Modulators of cAMP or cGMP, e.g. non-hydrolysable analogs, phosphodiesterase inhibitors, cholera toxin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/065—Modulators of histone acetylation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/10—Growth factors
- C12N2501/15—Transforming growth factor beta (TGF-β)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/602—Sox-2
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/603—Oct-3/4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/604—Klf-4
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/605—Nanog
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/60—Transcription factors
- C12N2501/608—Lin28
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/70—Enzymes
- C12N2501/72—Transferases [EC 2.]
- C12N2501/727—Kinases (EC 2.7.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/08—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from cells of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/09—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from epidermal cells, from skin cells, from oral mucosa cells
- C12N2506/094—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from epidermal cells, from skin cells, from oral mucosa cells from keratinocytes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
- C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
- C12N2506/28—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from vascular endothelial cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Pulmonology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Molecular Biology (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6995608P | 2008-03-17 | 2008-03-17 | |
| US19798608P | 2008-10-31 | 2008-10-31 | |
| PCT/US2009/037429 WO2009117439A2 (en) | 2008-03-17 | 2009-03-17 | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA201006683B true ZA201006683B (en) | 2011-11-30 |
Family
ID=41091504
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA2010/06683A ZA201006683B (en) | 2008-03-17 | 2010-09-17 | Combined chemical and genetic approaches for generation of induced pluripotent stem cells |
Country Status (15)
| Country | Link |
|---|---|
| US (8) | US9534205B2 (enExample) |
| EP (4) | EP2955222B1 (enExample) |
| JP (7) | JP5951254B2 (enExample) |
| KR (1) | KR101679082B1 (enExample) |
| CN (2) | CN102027105B (enExample) |
| AU (1) | AU2009225665B9 (enExample) |
| BR (1) | BRPI0908708A2 (enExample) |
| CA (1) | CA2718904C (enExample) |
| ES (1) | ES2690554T3 (enExample) |
| IL (1) | IL208144B (enExample) |
| MX (1) | MX2010010165A (enExample) |
| RU (1) | RU2010139426A (enExample) |
| SG (4) | SG10202103401QA (enExample) |
| WO (1) | WO2009117439A2 (enExample) |
| ZA (1) | ZA201006683B (enExample) |
Families Citing this family (189)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110171185A1 (en) * | 1999-06-30 | 2011-07-14 | Klimanskaya Irina V | Genetically intact induced pluripotent cells or transdifferentiated cells and methods for the production thereof |
| US7682828B2 (en) | 2003-11-26 | 2010-03-23 | Whitehead Institute For Biomedical Research | Methods for reprogramming somatic cells |
| ES2933478T3 (es) * | 2005-08-03 | 2023-02-09 | Astellas Inst For Regenerative Medicine | Métodos mejorados de reprogramación de células somáticas animales |
| US8883507B2 (en) | 2005-10-18 | 2014-11-11 | The Regents Of The University Of Colorado | Conditionally immortalized long-term hematopoietic stem cells and methods of making and using such cells |
| US8129187B2 (en) | 2005-12-13 | 2012-03-06 | Kyoto University | Somatic cell reprogramming by retroviral vectors encoding Oct3/4. Klf4, c-Myc and Sox2 |
| US8278104B2 (en) * | 2005-12-13 | 2012-10-02 | Kyoto University | Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2 |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| EP2206724A1 (en) * | 2005-12-13 | 2010-07-14 | Kyoto University | Nuclear reprogramming factor |
| MX348010B (es) | 2007-04-07 | 2017-05-23 | Whitehead Inst Biomedical Res | Reprogramacion de celulas somaticas. |
| US9213999B2 (en) * | 2007-06-15 | 2015-12-15 | Kyoto University | Providing iPSCs to a customer |
| JP2008307007A (ja) * | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| US20140342984A1 (en) * | 2007-10-19 | 2014-11-20 | Robert G. Matheny | Compositions for Regenerating Defective or Absent Myocardium |
| JP5951254B2 (ja) | 2008-03-17 | 2016-07-13 | ザ スクリプス リサーチ インスティテュート | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| CN102083982A (zh) * | 2008-04-07 | 2011-06-01 | 纽珀滕索有限公司 | 通过rna干扰引入复能基因而重编程细胞 |
| JP5346925B2 (ja) | 2008-05-02 | 2013-11-20 | 国立大学法人京都大学 | 核初期化方法 |
| SG10201803982TA (en) | 2008-05-16 | 2018-07-30 | Taiga Biotechnologies Inc | Antibodies and processes for preparing the same |
| WO2009152529A2 (en) | 2008-06-13 | 2009-12-17 | Whitehead Institute For Biomedical Research Nine Cambridge Center | Programming and reprogramming of cells |
| DK2313496T3 (en) | 2008-07-21 | 2014-12-15 | Taiga Biotechnologies Inc | Anukleære differentiated cells, and method for preparation thereof |
| US8298825B1 (en) | 2008-08-25 | 2012-10-30 | The General Hospital Corporation | TGF-beta receptor inhibitors to enhance direct reprogramming |
| US8784825B2 (en) | 2008-08-28 | 2014-07-22 | Taiga Biotechnologies, Inc. | Modulators of MYC, methods of using the same, and methods of identifying agents that modulate MYC |
| EP2376626A4 (en) * | 2008-12-13 | 2012-10-17 | Dna Microarray | MICRO-ENVIRONMENTAL NICHE ASSAY FOR SCREENING OF INDUCED PLURIPOTENT STEM CELLS (CIPS) |
| SG172160A1 (en) * | 2008-12-17 | 2011-07-28 | Scripps Research Inst | Generation and maintenance of stem cells |
| CA2748009A1 (en) * | 2008-12-23 | 2010-07-01 | Vivoscript, Inc. | Compositions and methods for re-programming cells without genetic modification |
| US20120128655A1 (en) * | 2009-04-03 | 2012-05-24 | The Mclean Hospital Corporation | Induced pluripotent stem cells |
| US9109245B2 (en) | 2009-04-22 | 2015-08-18 | Viacyte, Inc. | Cell compositions derived from dedifferentiated reprogrammed cells |
| JP5777113B2 (ja) | 2009-05-29 | 2015-09-09 | 学校法人慶應義塾 | 人工多能性幹細胞のクローンの選択方法 |
| JP5751548B2 (ja) * | 2009-08-07 | 2015-07-22 | 国立大学法人京都大学 | イヌiPS細胞及びその製造方法 |
| MX389666B (es) * | 2009-10-16 | 2025-03-19 | Scripps Research Inst | Induccion de celulas pluripotentes. |
| AU2014250681B2 (en) * | 2009-10-16 | 2016-12-15 | The Scripps Research Institute | Induction of pluripotent cells |
| AU2010312291A1 (en) | 2009-10-29 | 2012-06-21 | Mcmaster University | Generating induced pluripotent stem cells and progenitor cells from fibroblasts |
| LT2494039T (lt) * | 2009-10-31 | 2019-07-25 | Genesis Technologies Limited | Ląstelių perprogramavimo būdai ir jų panaudojimas |
| KR101775926B1 (ko) * | 2009-11-04 | 2017-09-07 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 화학 물질을 이용한 에피솜 재프로그래밍 |
| US20130189780A1 (en) * | 2009-12-31 | 2013-07-25 | Fate Therapeutics, Inc. | Reprogramming compositions |
| WO2011109015A1 (en) * | 2010-03-02 | 2011-09-09 | The Scripps Research Institute | Improved methods of generating pluripotent stem cells |
| EP2366432A1 (en) * | 2010-03-16 | 2011-09-21 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Inhibitors of glycogen synthase kinase 3 for use in therapeutic methods and screening method relating thereto |
| CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
| CN102260646B (zh) * | 2010-05-26 | 2015-09-16 | 北京瑞普晨创科技有限公司 | 一种制备诱导多潜能干细胞的方法,试剂盒及用途 |
| WO2011159726A2 (en) | 2010-06-14 | 2011-12-22 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| AU2011268056B2 (en) | 2010-06-18 | 2014-04-24 | Cellular Dynamics International, Inc. | Cardiomyocyte medium with dialyzed serum |
| WO2012007725A2 (en) * | 2010-07-16 | 2012-01-19 | Plasticell Ltd | Method of reprogramming a cell |
| WO2012030854A2 (en) | 2010-09-01 | 2012-03-08 | Whitehead Institute For Biomedical Research | Compositions and methods for modulating emt and uses thereof |
| WO2012031288A1 (en) * | 2010-09-03 | 2012-03-08 | United States Of America As Represented By The Department Of Veterans Affairs | Efficient generation of neurally-induced mesenchymal stem cells and applications thereof |
| US9447408B2 (en) | 2010-09-14 | 2016-09-20 | Kyoto University | Method of efficiently establishing induced pluripotent stem cells |
| JP6124791B2 (ja) * | 2010-09-22 | 2017-05-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ コロラド,ア ボディー コーポレイトTHE REGENTS OF THE UNIVERSITY OF COLORADO,a body corporate | Smad7の治療的適用 |
| KR101921350B1 (ko) * | 2010-12-17 | 2018-11-22 | 바이오라미나 에이비 | 인간 다능성 줄기세포를 유지하기 위한 시스템 |
| US9732319B2 (en) | 2010-12-22 | 2017-08-15 | Fate Therapeutics, Inc. | Cell culture platform for single cell sorting and enhanced reprogramming of iPSCs |
| US8956868B2 (en) * | 2010-12-27 | 2015-02-17 | Lsip, Llc | Induced pluripotent stem cells produced with a connexin inhibitor and a TGF-β signaling inhibitor |
| WO2012098260A1 (en) * | 2011-01-21 | 2012-07-26 | Axiogenesis Ag | A non-viral system for the generation of induced pluripotent stem (ips) cells |
| PT2705143T (pt) * | 2011-05-02 | 2021-04-07 | Univ Wayne State | Tecnologia de células pluripotentes induzidas por proteínas e utilizações da mesma |
| WO2012166973A1 (en) | 2011-06-01 | 2012-12-06 | Sanford-Burnham Medical Research Institute | Methods for promoting cell reprogramming |
| US10865383B2 (en) | 2011-07-12 | 2020-12-15 | Lineage Cell Therapeutics, Inc. | Methods and formulations for orthopedic cell therapy |
| US20140289882A1 (en) * | 2011-07-19 | 2014-09-25 | Oregon Health And Science University | Compositions and methods for re-programming cells without genetic modification for repairing cartilage damage |
| JP6143265B2 (ja) | 2011-07-25 | 2017-06-07 | 国立大学法人京都大学 | 人工多能性幹細胞の選別方法 |
| US20140248698A1 (en) | 2011-10-21 | 2014-09-04 | Arkray, Inc. | Method for culturing pluripotency-maintained singly dispersed cells by means of laminar flow |
| WO2013077423A1 (ja) | 2011-11-25 | 2013-05-30 | 国立大学法人京都大学 | 多能性幹細胞の培養方法 |
| US8497124B2 (en) | 2011-12-05 | 2013-07-30 | Factor Bioscience Inc. | Methods and products for reprogramming cells to a less differentiated state |
| EP3260140B1 (en) | 2011-12-05 | 2021-02-03 | Factor Bioscience Inc. | Methods and products for transfecting cells |
| WO2013131000A1 (en) * | 2012-03-01 | 2013-09-06 | Whitehead Institute For Biomedical Research | Emt-inducing transcription factors cooperate with sox9 |
| EP2825637A4 (en) * | 2012-03-14 | 2015-12-23 | Childrens Medical Center | PICTORIAL-BASED CHEMICAL SCREENING WITH HIGH PASSAGE IN A ZEBRAFISH BLASTOMER CELL CULTURE |
| JP6285930B2 (ja) | 2012-07-20 | 2018-02-28 | タイガ バイオテクノロジーズ,インク. | 造血コンパートメントの再構築及び自家再構築の増進 |
| US10357517B1 (en) * | 2012-10-01 | 2019-07-23 | University Of South Florida | Methods of treating epilepsy using neural stem cells that express nanog, SSEA-4, OCT-4, MIR-34B, MIR-34C and MIR-592 |
| CA2890110C (en) | 2012-11-01 | 2023-05-02 | Factor Bioscience Inc. | Methods and products for expressing proteins in cells |
| WO2014071323A2 (en) * | 2012-11-02 | 2014-05-08 | Duke University | Inhibition of histone methyltransferase for cardiac reprogramming |
| EP2943564B1 (en) * | 2013-01-09 | 2026-03-25 | International Stem Cell Corporation | Sl327 for use in skin regeneration |
| EP2955223B1 (en) | 2013-02-08 | 2019-12-18 | Kyoto University | Production methods for megakaryocytes and platelets |
| US9738861B2 (en) | 2013-03-06 | 2017-08-22 | Kyoto University | Culture system for pluripotent stem cells and method for subculturing pluripotent stem cells |
| US9422352B2 (en) | 2013-03-08 | 2016-08-23 | The Regents Of The University Of Colorado, A Body Corporate | PTD-SMAD7 therapeutics |
| US9365825B2 (en) * | 2013-03-11 | 2016-06-14 | Taiga Biotechnologies, Inc. | Expansion of adult stem cells in vitro |
| US10272115B2 (en) | 2013-03-11 | 2019-04-30 | Taiga Biotechnologies, Inc. | Production and use of red blood cells |
| US8859286B2 (en) | 2013-03-14 | 2014-10-14 | Viacyte, Inc. | In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells |
| BR112015023261A2 (pt) | 2013-03-14 | 2017-07-18 | Massachusetts Inst Technology | composições e métodos para expansão e cultura de células-tronco epiteliais |
| SG11201507829SA (en) | 2013-03-21 | 2015-12-30 | Univ Kyoto | Pluripotent stem cell for neuronal differentiation induction |
| JP6473686B2 (ja) | 2013-03-25 | 2019-02-20 | 公益財団法人神戸医療産業都市推進機構 | 細胞の選別方法 |
| KR20140121317A (ko) * | 2013-04-06 | 2014-10-15 | 서울대학교산학협력단 | 비신경 세포로부터 유도 신경 줄기 세포의 생산 방법 및 이에 의하여 생산되는 유도 신경 줄기 세포 |
| JP6461787B2 (ja) | 2013-04-12 | 2019-01-30 | 国立大学法人京都大学 | 肺胞上皮前駆細胞の誘導方法 |
| WO2014185358A1 (ja) | 2013-05-14 | 2014-11-20 | 国立大学法人京都大学 | 効率的な心筋細胞の誘導方法 |
| KR101870174B1 (ko) | 2013-05-31 | 2018-06-22 | 아이하트 재팬 가부시키가이샤 | 하이드로겔을 포함하는 적층화된 세포 시트 |
| MX2015017036A (es) | 2013-06-11 | 2016-07-21 | Univ Kyoto | Metodo para producir celulas progenitoras renales y farmaco que comprende las mismas. |
| CN104278008B (zh) * | 2013-07-12 | 2020-08-21 | 北京宏冠再生医学科技有限公司 | 一种通过小分子化合物处理来制备多潜能干细胞的方法、试剂盒和用途 |
| KR101655383B1 (ko) | 2013-07-27 | 2016-09-08 | 고려대학교 산학협력단 | 소분자 화합물을 포함하는 만능성 줄기세포의 염색체 안정성 유지용 조성물 |
| JP6378183B2 (ja) | 2013-08-07 | 2018-08-22 | 国立大学法人京都大学 | 膵ホルモン産生細胞の製造法 |
| CN121136933A (zh) | 2013-09-05 | 2025-12-16 | 国立大学法人京都大学 | 由多能干细胞制造产多巴胺神经前体细胞的方法、产多巴胺神经前体细胞、帕金森病治疗剂和试剂盒 |
| CN104419683A (zh) * | 2013-09-10 | 2015-03-18 | 中国科学院生物物理研究所 | 制备范可尼贫血症患者自体诱导多能干细胞的方法及其应用 |
| EP3060649A4 (en) * | 2013-10-23 | 2017-07-12 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Reprogramming cardiomyocytes with one transcription factor |
| KR102113829B1 (ko) | 2013-10-25 | 2020-05-25 | 웨인 스테이트 유니버시티 | 단백질-유도 생체내 세포 재프로그래밍을 통한 세포 전환 방법, 시스템 및 조성물 |
| EP3064577B1 (en) | 2013-11-01 | 2020-09-09 | Kyoto University | Novel chondrocyte induction method |
| US9512406B2 (en) | 2013-12-20 | 2016-12-06 | The J. David Gladstone Institute, a testamentary trust established under the Will of J. David Gladstone | Generating hepatocytes |
| KR102415811B1 (ko) | 2014-01-31 | 2022-07-04 | 팩터 바이오사이언스 인크. | 핵산 제조 및 송달을 위한 방법 및 산물 |
| CN104894060B (zh) * | 2014-03-03 | 2018-11-06 | 中国科学院上海生命科学研究院 | 诱导体细胞转分化为神经干细胞的方法及其应用 |
| CN120536341A (zh) | 2014-03-04 | 2025-08-26 | 菲特治疗公司 | 改良的重编程方法和细胞培养平台 |
| EP3929302A1 (en) | 2014-07-14 | 2021-12-29 | Chugai Seiyaku Kabushiki Kaisha | Method for identifying epitope on protein |
| WO2016008982A1 (en) * | 2014-07-16 | 2016-01-21 | Fundación Pública Andaluza Progreso Y Salud | Methods for generating induced pluripotent stem cells |
| AU2015290554A1 (en) | 2014-07-18 | 2017-03-09 | Kyoto University | Method for inducing T cells for cell-based immunotherapy from pluripotent stem cells |
| US20160030484A1 (en) | 2014-08-04 | 2016-02-04 | University Of Kansas | Mammalian pluripotent stem cells, methods for their production, and uses thereof |
| RU2565548C1 (ru) * | 2014-08-05 | 2015-10-20 | Дмитрий Андреевич Журавлёв | Способ получения плюрипотентных стволовых клеток |
| EP3177709B1 (en) | 2014-08-07 | 2022-05-18 | The J. David Gladstone Institutes, A Testamentary Trust Established under The Will of J. David Gladstone | Reversible stencils for fabricating micro-tissues |
| CN107073042A (zh) * | 2014-09-03 | 2017-08-18 | 布里格海姆妇女医院公司 | 用于产生内耳毛细胞来治疗听力损失的组合物、系统和方法 |
| US10711249B2 (en) | 2014-12-26 | 2020-07-14 | Kyoto University | Method for inducing hepatocytes |
| WO2016117139A1 (ja) * | 2015-01-20 | 2016-07-28 | タカラバイオ株式会社 | 神経系細胞の製造方法 |
| CA2974903A1 (en) | 2015-01-26 | 2016-08-04 | Fate Therapeutics, Inc. | Cells with increased immuno-regulatory properties and methods for their use and manufacture |
| US10767165B2 (en) * | 2015-01-30 | 2020-09-08 | Centre National De La Recherche Scientifique (Cnrs) | Reprogramming method for producing induced pluripotent stem cells (iPSC) |
| US11241505B2 (en) | 2015-02-13 | 2022-02-08 | Factor Bioscience Inc. | Nucleic acid products and methods of administration thereof |
| JP2018510649A (ja) | 2015-02-17 | 2018-04-19 | ユニバーシティー ヘルス ネットワーク | 洞房結節様ペースメーカー心筋細胞および心室様心筋細胞を作製および使用するための方法 |
| EP3081638A1 (en) | 2015-04-16 | 2016-10-19 | Kyoto University | Method for producing pseudo-islets |
| BR112018001232A2 (pt) | 2015-07-21 | 2018-09-25 | The Children's Medical Center Corporation | pd-l1 que expressa células-tronco hematopoéticas e usos |
| CN108350433B (zh) * | 2015-08-21 | 2021-11-30 | 京都府公立大学法人 | 成骨细胞及其制备方法 |
| CN117737124A (zh) * | 2015-10-16 | 2024-03-22 | 菲特治疗公司 | 用于诱导和维护基态多能性的平台 |
| KR20260079466A (ko) * | 2015-10-21 | 2026-06-01 | 교토후고리츠다이가쿠호진 | 세포의 조제 방법 |
| CA3010610A1 (en) | 2016-01-08 | 2017-07-13 | The Brigham And Women's Hospital, Inc. | Production of differentiated enteroendocrine cells and insulin producing cells |
| KR20180114032A (ko) * | 2016-01-08 | 2018-10-17 | 국립연구개발법인 고쿠리츠간켄큐센터 | 저분자 화합물에 의한 성숙 간세포로부터의 간 줄기/전구세포의 제작 방법 |
| AU2017210031C1 (en) | 2016-01-20 | 2020-11-26 | Fate Therapeutics, Inc. | Compositions and methods for immune cell modulation in adoptive immunotherapies |
| JP7653759B2 (ja) | 2016-01-20 | 2025-03-31 | フェイト セラピューティクス,インコーポレイテッド | 養子免疫療法における免疫細胞調節のための組成物および方法 |
| US10201540B2 (en) | 2016-03-02 | 2019-02-12 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I |
| US10213511B2 (en) | 2016-03-02 | 2019-02-26 | Frequency Therapeutics, Inc. | Thermoreversible compositions for administration of therapeutic agents |
| US11260130B2 (en) | 2016-03-02 | 2022-03-01 | Frequency Therapeutics, Inc. | Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV |
| LT3444334T (lt) | 2016-04-15 | 2021-12-10 | Kyoto University | Antigenui specifinių cd8 teigiamų t ląstelių indikavimo būdas |
| EP3447130A4 (en) | 2016-04-22 | 2019-11-13 | Kyoto University | METHOD FOR PRODUCING DOPAMINE-PROPERING NEURAL PRESERVATOR CELLS |
| CN105943526B (zh) * | 2016-05-18 | 2018-08-14 | 上海交通大学医学院附属上海儿童医学中心 | Pd0325901在维持动脉导管开放中的应用 |
| EP3483262B1 (en) * | 2016-06-03 | 2021-11-17 | Institue of Transfusion Medicine, Academy of Military Medical Sciences, People's Liberation Army of China | Small molecule compound combination for reprogramming digestive tract derived epithelial cells to endodermal stem/progenitor cells, reprogramming method and application |
| US20190322643A1 (en) * | 2016-06-29 | 2019-10-24 | Georgia State University Research Foundation, Inc. | Histone deacetylase and histone methyltransferase inhibitors and methods of making and use of the same |
| IL264439B2 (en) | 2016-08-17 | 2024-08-01 | Factor Bioscience Inc | non-viral, cell-free composition comprising a synthetic messenger RNA (MRNA) encoding a gene-editing protein for use in treating cancer, and a synthetic RNA encoding a gene-editing protein for use in treatment |
| JP7134416B2 (ja) * | 2016-10-28 | 2022-09-12 | 国立研究開発法人国立がん研究センター | ヒト肝前駆細胞の調製方法 |
| US10583156B2 (en) | 2016-12-02 | 2020-03-10 | Taiga Biotechnologies, Inc. | Nanoparticle formulations |
| US11932870B2 (en) | 2016-12-05 | 2024-03-19 | Fate Therapeutics, Inc. | Compositions and methods for immune cell modulation in adoptive immunotherapies |
| US20200141921A1 (en) | 2016-12-27 | 2020-05-07 | Sumitomo Chemical Company, Limited | Evaluation method and selection method for induced pluripotent stem cells, and production method for induced pluripotent stem cells |
| CN106754655B (zh) * | 2016-12-29 | 2020-06-19 | 赛业(苏州)生物科技有限公司 | 一种动物胚胎培养基 |
| AU2017386417B2 (en) | 2016-12-30 | 2022-07-14 | Frequency Therapeutics, Inc. | 1H-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells |
| EP3572502B1 (en) | 2017-01-20 | 2023-01-11 | Kyoto University | Method for producing cd8alpha +beta + cytotoxic t cells |
| US20210130785A1 (en) | 2017-01-26 | 2021-05-06 | Osaka University | Medium for inducing differentiation of stem cells into mesodermal cells and method for producing mesodermal cells |
| JP7171055B2 (ja) | 2017-03-14 | 2022-11-15 | 国立大学法人京都大学 | 多能性幹細胞からヘルパーt細胞を製造する方法 |
| WO2018216743A1 (ja) | 2017-05-25 | 2018-11-29 | 国立大学法人京都大学 | 中間中胚葉細胞から腎前駆細胞への分化誘導方法、および多能性幹細胞から腎前駆細胞への分化誘導方法 |
| WO2018235583A1 (ja) | 2017-06-19 | 2018-12-27 | 公益財団法人神戸医療産業都市推進機構 | 多能性幹細胞の分化能の予測方法及びそのための試薬 |
| US10149898B2 (en) | 2017-08-03 | 2018-12-11 | Taiga Biotechnologies, Inc. | Methods and compositions for the treatment of melanoma |
| US20190062711A1 (en) * | 2017-08-25 | 2019-02-28 | So Young Life Sciences Corporation | Use Of Phosphorylated TBeta4 And Other Factors To Generate Human Induced Pluripotent Stem Cells |
| WO2019060708A1 (en) | 2017-09-22 | 2019-03-28 | The Children's Medical Center Corporation | TREATMENT OF TYPE 1 DIABETES AND AUTOIMMUNE DISEASES OR DISORDERS |
| EP3699267A4 (en) | 2017-10-17 | 2021-10-27 | Kyoto University | METHOD OF MANUFACTURING AN ARTIFICIAL NEUROMUSCULAR END PLATE FROM PLURIPOTENT STEM CELLS |
| KR101810008B1 (ko) | 2017-10-23 | 2018-01-18 | 차의과학대학교 산학협력단 | 역분화-증진제를 이용한 인간-유래의 체세포로부터 역분화 만능 줄기세포의 제조방법 |
| KR101810014B1 (ko) | 2017-10-23 | 2018-01-18 | 차의과학대학교 산학협력단 | 히스톤 데아세틸라제 저해제 및 골 형성 단백질 경로 차단제를 이용한 인간-유래의 체세포로부터 역분화 만능 줄기세포의 제조방법 |
| KR101998633B1 (ko) * | 2017-10-31 | 2019-07-11 | 가톨릭관동대학교산학협력단 | 엘립티신의 줄기세포의 연골세포로의 분화 유도 용도 |
| CN108624562B (zh) * | 2018-05-18 | 2021-11-02 | 首都医科大学附属北京朝阳医院 | 一种制备肿瘤干细胞的方法及其专用试剂盒 |
| KR102158783B1 (ko) * | 2018-06-18 | 2020-09-22 | 한국생명공학연구원 | 세포 리프로그래밍 조성물 및 이를 이용한 유도만능줄기세포의 제조방법 |
| EP3822342A4 (en) | 2018-07-13 | 2022-08-03 | Kyoto University | METHOD OF PRODUCTION OF GAMMA DELTA T-CELLS |
| US20210299331A1 (en) | 2018-07-19 | 2021-09-30 | Kyoto University | Pluripotent stem cell-derived plate-shaped cartilage and method for producing the same |
| WO2020022261A1 (ja) | 2018-07-23 | 2020-01-30 | 国立大学法人京都大学 | 新規腎前駆細胞マーカーおよびそれを利用した腎前駆細胞の濃縮方法 |
| WO2020037323A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by upregulating jag-1 |
| WO2020037326A1 (en) | 2018-08-17 | 2020-02-20 | Frequency Therapeutics, Inc. | Compositions and methods for generating hair cells by downregulating foxo |
| US12168781B2 (en) | 2018-12-06 | 2024-12-17 | Kirin Holdings Kabushiki Kaisha | Production method for T cells or NK cells, medium for culturing T cells or NK cells, method for culturing T cells or NK cells, method for maintaining undifferentiated state of undifferentiated T cells, and growth-accelerating agent for T cells or NK cells |
| WO2020130147A1 (ja) | 2018-12-21 | 2020-06-25 | 国立大学法人京都大学 | ルブリシン局在軟骨様組織、その製造方法及びそれを含む関節軟骨損傷治療用組成物 |
| US20220062341A1 (en) | 2018-12-26 | 2022-03-03 | Kirin Holdings Kabushiki Kaisha | Modified tcr and production method therefor |
| EP3952909A4 (en) | 2019-04-08 | 2023-06-07 | Taiga Biotechnologies, Inc. | COMPOSITIONS AND METHODS FOR CRYOPRESERVING IMMUNE CELLS |
| SG11202112529WA (en) | 2019-05-14 | 2021-12-30 | Taiga Biotechnologies Inc | Compositions and methods for treating t cell exhaustion |
| WO2020230832A1 (ja) | 2019-05-15 | 2020-11-19 | 味の素株式会社 | 神経堤細胞または角膜上皮細胞の純化方法 |
| JPWO2020235319A1 (enExample) | 2019-05-20 | 2020-11-26 | ||
| CA3145425A1 (en) | 2019-07-03 | 2021-01-07 | Factor Bioscience Inc. | Cationic lipids and uses thereof |
| WO2021015228A1 (ja) * | 2019-07-25 | 2021-01-28 | 富士フイルム株式会社 | 特定の分化細胞の製造方法 |
| US10501404B1 (en) | 2019-07-30 | 2019-12-10 | Factor Bioscience Inc. | Cationic lipids and transfection methods |
| CN112301052A (zh) | 2019-08-01 | 2021-02-02 | 浙江霍德生物工程有限公司 | 一种通过体细胞重编程制备诱导多功能干细胞的方法 |
| JP7058431B2 (ja) | 2019-12-12 | 2022-04-22 | 国立大学法人千葉大学 | 巨核球および血小板を含む凍結乾燥製剤 |
| KR102087084B1 (ko) * | 2020-02-03 | 2020-03-10 | 주식회사 이에이치엘바이오 | 항노화인자를 발현하는 지방유래 줄기세포의 대량 배양방법 |
| JP7842690B2 (ja) | 2020-02-19 | 2026-04-08 | ナミ セラピューティクス, インコーポレイテッド | がんの処置において有用なTFGβアンタゴニストプロドラッグを含有する製剤化および/または共製剤化リポソーム組成物ならびにその方法 |
| IL295964A (en) | 2020-02-28 | 2022-10-01 | Takeda Pharmaceuticals Co | A method for producing natural killer cells from pluripotent stem cells |
| CN115885038A (zh) | 2020-06-17 | 2023-03-31 | 国立大学法人京都大学 | 表达嵌合抗原受体的免疫活性细胞 |
| US20230256024A1 (en) | 2020-07-13 | 2023-08-17 | Kyoto University | Skeletal muscle precursor cells and method for purifying same, composition for treating myogenic diseases, and method for producing cell group containing skeletal muscle precursor cells |
| WO2022019152A1 (ja) | 2020-07-20 | 2022-01-27 | 学校法人 愛知医科大学 | 多能性細胞の未分化維持培養用組成物、多能性細胞の未分化維持培養用培地、多能性細胞の未分化状態での維持培養方法、および多能性細胞の製造方法 |
| JPWO2022039279A1 (enExample) | 2020-08-18 | 2022-02-24 | ||
| EP4310176A4 (en) | 2021-03-17 | 2025-03-26 | Astellas Pharma Inc. | Pericyte with basic fibroblast growth factor (BFGF) gene inserted into it |
| CA3218400A1 (en) | 2021-04-30 | 2022-11-03 | Riken | Cord-like aggregates of retinal pigment epithelial cells, device and production method for producing same, and therapeutic agent comprising said cord-like aggregates |
| US20240254441A1 (en) | 2021-06-04 | 2024-08-01 | Kirin Holdings Kabushiki Kaisha | Cell composition, method for producing cell composition, and pharmaceutical composition containing cell composition |
| WO2022259721A1 (ja) | 2021-06-10 | 2022-12-15 | 味の素株式会社 | 間葉系幹細胞の製造方法 |
| CN117813374A (zh) | 2021-06-15 | 2024-04-02 | 武田药品工业株式会社 | 从多能干细胞产生自然杀伤细胞的方法 |
| US20240309320A1 (en) * | 2021-07-08 | 2024-09-19 | The Broad Institute, Inc. | Methods for differentiating and screening stem cells |
| EP4372079A4 (en) | 2021-07-15 | 2025-07-30 | Astellas Pharma Inc | PERICYTE-LIKE CELLS EXPRESSING VASCULAR ENDOTHELIAL GROWTH FACTOR (VEGF) AT A HIGH LEVEL |
| US20240335480A1 (en) | 2021-07-15 | 2024-10-10 | Astellas Pharma Inc. | Vascular endothelial growth factor (vegf)-highly expressing pericyte-like cell |
| EP4386083A4 (en) | 2021-08-11 | 2025-11-12 | Univ Kyoto | METHOD FOR PRODUCING RENAL INTERSTITIAL PROGENITOR CELLS, ERYTHROPOIETIN-PRODUCING CELLS AND METHOD FOR PRODUCING RENIIN-PRODUCING CELLS |
| JPWO2023074648A1 (enExample) * | 2021-10-25 | 2023-05-04 | ||
| CN118265792A (zh) | 2021-11-11 | 2024-06-28 | 希里欧斯株式会社 | 基因修饰多能干细胞、来自其的免疫活性细胞、它们的制造方法和它们的用途 |
| JPWO2023153464A1 (enExample) | 2022-02-09 | 2023-08-17 | ||
| CN116694551A (zh) * | 2022-02-24 | 2023-09-05 | 清华大学 | 诱导性成熟肝脏细胞及其制备的方法 |
| JPWO2023210713A1 (enExample) | 2022-04-27 | 2023-11-02 | ||
| CN114702591B (zh) * | 2022-05-17 | 2022-09-23 | 诺赛联合(北京)生物医学科技有限公司 | 成体细胞衍生的类器官制备技术 |
| CN119365606A (zh) | 2022-06-10 | 2025-01-24 | 国立大学法人京都大学 | 未分化多能干细胞的检测方法和检测试剂 |
| WO2024078118A1 (en) * | 2022-10-12 | 2024-04-18 | Peking University | Chemical reprogramming and pluripotent stem cells |
| KR102887911B1 (ko) | 2022-11-04 | 2025-11-19 | 건국대학교 글로컬산학협력단 | 분화된 세포의 유도만능줄기세포로의 리프로그래밍 효율 증진 방법 |
| CN115772495B (zh) * | 2022-12-02 | 2025-05-16 | 上海交通大学医学院附属第九人民医院 | 一种诱导胚胎干细胞定向分化为外胚层软骨祖细胞的培养基、方法及用途 |
| WO2024248017A1 (ja) | 2023-05-29 | 2024-12-05 | 国立研究開発法人理化学研究所 | 心筋細胞を成熟させる方法及び成熟した心筋細胞の製造方法 |
| EP4722343A1 (en) | 2023-05-29 | 2026-04-08 | Kansai Medical University Educational Corporation | Method for producing suprachiasmatic nucleus organoid |
| CN121195060A (zh) | 2023-05-31 | 2025-12-23 | 学校法人顺天堂 | 源自多能干细胞的cd4阳性t细胞、其制造方法以及其用途 |
| WO2025135136A1 (ja) | 2023-12-20 | 2025-06-26 | 学校法人関西医科大学 | 爪母細胞の製造方法 |
| WO2026030659A1 (en) * | 2024-08-01 | 2026-02-05 | Colossal Biosciences Inc. | Methods of generating rock hyrax ipsc |
Family Cites Families (106)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR901228A (fr) | 1943-01-16 | 1945-07-20 | Deutsche Edelstahlwerke Ag | Système d'aimant à entrefer annulaire |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| US5010175A (en) | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| IE66205B1 (en) | 1990-06-14 | 1995-12-13 | Paul A Bartlett | Polypeptide analogs |
| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| US5384253A (en) | 1990-12-28 | 1995-01-24 | Dekalb Genetics Corporation | Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes |
| WO1993004169A1 (en) | 1991-08-20 | 1993-03-04 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5702932A (en) | 1992-07-20 | 1997-12-30 | University Of Florida | Microinjection methods to transform arthropods with exogenous DNA |
| US5288514A (en) | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| WO1995003402A1 (en) | 1993-07-22 | 1995-02-02 | Merck & Co., Inc. | EXPRESSION OF HUMAN INTERLEUKIN-1β IN A TRANSGENIC ANIMAL |
| US5519134A (en) | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
| US5593853A (en) | 1994-02-09 | 1997-01-14 | Martek Corporation | Generation and screening of synthetic drug libraries |
| US5539083A (en) | 1994-02-23 | 1996-07-23 | Isis Pharmaceuticals, Inc. | Peptide nucleic acid combinatorial libraries and improved methods of synthesis |
| US5656610A (en) | 1994-06-21 | 1997-08-12 | University Of Southern California | Producing a protein in a mammal by injection of a DNA-sequence into the tongue |
| US5525735A (en) | 1994-06-22 | 1996-06-11 | Affymax Technologies Nv | Methods for synthesizing diverse collections of pyrrolidine compounds |
| US5549974A (en) | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| US5736524A (en) | 1994-11-14 | 1998-04-07 | Merck & Co.,. Inc. | Polynucleotide tuberculosis vaccine |
| US5843780A (en) | 1995-01-20 | 1998-12-01 | Wisconsin Alumni Research Foundation | Primate embryonic stem cells |
| US5569588A (en) | 1995-08-09 | 1996-10-29 | The Regents Of The University Of California | Methods for drug screening |
| US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
| US5780448A (en) | 1995-11-07 | 1998-07-14 | Ottawa Civic Hospital Loeb Research | DNA-based vaccination of fish |
| GB9807935D0 (en) | 1998-04-14 | 1998-06-10 | Univ Edinburgh | Lineage specific cells and progenitor cells |
| US5945100A (en) | 1996-07-31 | 1999-08-31 | Fbp Corporation | Tumor delivery vehicles |
| US5981274A (en) | 1996-09-18 | 1999-11-09 | Tyrrell; D. Lorne J. | Recombinant hepatitis virus vectors |
| WO1998050048A1 (en) | 1997-05-07 | 1998-11-12 | Pharma Mar, S.A. | Aplidine as an l-type calcium channel enhancer |
| CA2292339A1 (en) | 1997-06-13 | 1998-12-17 | Ludwig Institute For Cancer Research | Smad6 and uses thereof |
| US5994624A (en) | 1997-10-20 | 1999-11-30 | Cotton Incorporated | In planta method for the production of transgenic plants |
| US5994136A (en) | 1997-12-12 | 1999-11-30 | Cell Genesys, Inc. | Method and means for producing high titer, safe, recombinant lentivirus vectors |
| USH1963H1 (en) | 1998-01-16 | 2001-06-05 | Dresser Industries, Inc. | High pressure differential electrical connector |
| US20060263382A1 (en) | 1998-06-20 | 2006-11-23 | Richard Hotchkiss | Membrane-permeant peptide complexes for treatment of sepsis |
| EP1100872A1 (en) | 1998-07-24 | 2001-05-23 | Carnegie Institution Of Washington | Method for maintenance and propagation of germline stem cells using members of the tgf-beta family of growth factors |
| GB9819912D0 (en) * | 1998-09-11 | 1998-11-04 | Univ Edinburgh | Propagation and/or derivation of embryonic stem cells |
| CA2350234A1 (en) | 1999-01-07 | 2000-07-13 | Alexander James Bridges | Treatment of asthma with mek inhibitors |
| US6703420B1 (en) | 1999-03-19 | 2004-03-09 | Bristol-Myers Squibb Pharma Company | Amino-thio-acrylonitriles as MEK inhibitors |
| US6730293B1 (en) | 1999-08-24 | 2004-05-04 | Cellgate, Inc. | Compositions and methods for treating inflammatory diseases of the skin |
| US20020142457A1 (en) | 1999-12-28 | 2002-10-03 | Akihiro Umezawa | Cell having the potentiality of differentiation into cardiomyocytes |
| WO2008108741A1 (en) | 2007-03-07 | 2008-09-12 | S*Bio Pte Ltd | Combination of benzimidazole anti-cancer agent and a second anti-cancer agent |
| WO2003025151A2 (en) * | 2001-09-21 | 2003-03-27 | University Of Rochester | Circadian control of stem/progenitor cell self-renewal and differentiation and of clock controlled gene expression |
| SI1456380T1 (sl) | 2001-11-02 | 2012-11-30 | Giuliani Int Ltd | Smad inhibitorji za zdravljenje cns bolezni |
| ATE306810T1 (de) * | 2002-03-05 | 2005-11-15 | Artemis Pharmaceuticals Gmbh | Durch inzucht erzeugte von embryonalen stammzellen abgeleitete mäuse |
| GB0210539D0 (en) | 2002-05-08 | 2002-06-19 | Univ Edinburgh | Control of es cell self renewal and lineage specification, and medium therefor |
| EP1562601A1 (en) | 2002-11-15 | 2005-08-17 | Warner-Lambert Company LLC | Combination chemotherapy comprising a mek inhibitor and capecitabine for treating cancer |
| WO2004072068A1 (en) | 2003-02-10 | 2004-08-26 | Amgen Inc. | Vanilloid receptor ligands and their use in treatments |
| AU2003901099A0 (en) | 2003-03-11 | 2003-03-27 | Es Cell International Pte Ltd. | Methods of inducing differentiation of stem cells |
| US20070010008A1 (en) | 2005-06-29 | 2007-01-11 | Tissuetech, Inc. | Ex vivo expansion of primary animal cells |
| US20060222657A1 (en) | 2003-06-20 | 2006-10-05 | Dowdy Steven F | Polypeptide transduction and fusogenic peptides |
| BRPI0414961A (pt) | 2003-10-03 | 2006-11-07 | Keiichi Fukuda | processo de indução da diferenciação de células tronco em células do miocárdio |
| GB2407048B (en) | 2003-10-15 | 2007-07-11 | Biotrace Internat Plc | Laboratory apparatus |
| CA2542276A1 (en) | 2003-10-16 | 2005-04-28 | The University Court Of The University Of Edinburgh | Control of es cell self-renewal and lineage specification, and medium therefor |
| WO2005049812A1 (en) | 2003-11-19 | 2005-06-02 | Australian Stem Cell Centre Limited | Methods for producing blood products from pluripotent cells in cell culture |
| US20070269412A1 (en) | 2003-12-02 | 2007-11-22 | Celavie Biosciences, Llc | Pluripotent cells |
| US8187878B2 (en) | 2004-08-13 | 2012-05-29 | University Of Georgia Research Foundation, Inc. | Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors |
| WO2006026473A2 (en) | 2004-08-25 | 2006-03-09 | University Of Georgia Research Foundation, Inc. | METHODS AND COMPOSITIONS UTILIZING MYC AND GSK3ß TO MANIPULATE THE PLURIPOTENCY OF EMBRYONIC STEM CELLS |
| US20060182724A1 (en) | 2005-02-15 | 2006-08-17 | Riordan Neil H | Method for expansion of stem cells |
| KR101004634B1 (ko) * | 2005-08-01 | 2011-01-04 | 뉴포텐셜, 인크. | 잠재력이 복원된 리프로그래밍된 세포의 제조 |
| WO2007030693A2 (en) | 2005-09-08 | 2007-03-15 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for promoting stem cell proliferation and survival |
| JP5249770B2 (ja) * | 2005-11-03 | 2013-07-31 | バーテックス ファーマシューティカルズ インコーポレイテッド | キナーゼインヒビターとして有用なアミノピリジン |
| US8217042B2 (en) * | 2005-11-11 | 2012-07-10 | Zentaris Gmbh | Pyridopyrazines and their use as modulators of kinases |
| TW200730623A (en) * | 2005-11-11 | 2007-08-16 | Univ Edinburgh | Reprogramming and genetic modification of cells |
| EP2206724A1 (en) | 2005-12-13 | 2010-07-14 | Kyoto University | Nuclear reprogramming factor |
| US20090227032A1 (en) | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| JP5024049B2 (ja) | 2005-12-16 | 2012-09-12 | 株式会社明電舎 | 真空コンデンサ |
| GB0601538D0 (en) * | 2006-01-26 | 2006-03-08 | Univ Birmingham | Epigenetic analysis |
| EP1992360A4 (en) | 2006-02-01 | 2010-02-17 | Univ Tokyo | COMMON USE OF A TGF BETA SIGNAL HEMMER AND AN ANTITUMORAL AGENT |
| US7541186B2 (en) | 2006-02-22 | 2009-06-02 | University Of Washington | Method of generating human retinal progenitors from embryonic stem cells |
| GB0615327D0 (en) | 2006-03-30 | 2006-09-13 | Univ Edinburgh | Culture medium containing kinase inhibitors and uses thereof |
| WO2007113505A2 (en) | 2006-03-30 | 2007-10-11 | The University Court Of The University Of Edinburgh | Culture medium containing kinase inhibitors. and uses thereof |
| US8741643B2 (en) | 2006-04-28 | 2014-06-03 | Lifescan, Inc. | Differentiation of pluripotent stem cells to definitive endoderm lineage |
| GB2452186B (en) | 2006-05-02 | 2011-01-26 | Wisconsin Alumni Res Found | Method of differentiating stem cells into cells of the endoderm and pancreatic lineage |
| GB2437737B (en) | 2006-05-04 | 2008-07-09 | Access Products Ltd | Scaffolding |
| WO2008005268A1 (en) | 2006-06-30 | 2008-01-10 | Schering Corporation | Substituted piperidines that increase p53 activity and the uses thereof |
| CA2657227A1 (en) | 2006-07-14 | 2008-01-17 | Novartis Ag | Pyrimidine derivatives as alk-5 inhibitors |
| US20080020014A1 (en) | 2006-07-19 | 2008-01-24 | Paul Consigny | Implantable devices containing nuclear receptor ligands for the treatment of vascular and related disorders |
| GB0622395D0 (en) | 2006-11-09 | 2006-12-20 | Univ Cambridge Tech | Methods relating to pluripotent cells |
| SE0950586L (sv) | 2007-01-17 | 2009-08-13 | Wisconsin Alumni Res Found | Förbättrad odling av stamceller |
| WO2008088882A2 (en) | 2007-01-19 | 2008-07-24 | The J. David Gladstone Institutes | Methods of generating cardiomyocytes |
| EP2126045A4 (en) | 2007-01-30 | 2010-05-26 | Univ Georgia | EARLY MESODERM CELLS, STABLE POPULATION OF MESENDODERM CELLS WITH THE ABILITY TO GENERATE ENDODERM AND MESODERM CELL LINES AND MULTIPOTENTIAL MIGRATION CELLS |
| WO2008105630A1 (en) | 2007-02-27 | 2008-09-04 | Procell Therapeutics Inc. | Combined use of cell permeable nanog and oct4 for increasing self-renewal and suppressing differentiation of stem cells |
| WO2008126932A2 (en) | 2007-04-09 | 2008-10-23 | Riken | Epigenetical regulation of brain plasticity |
| CA2684460C (en) * | 2007-04-18 | 2017-01-03 | Hadasit Medical Research Services & Development Limited | Stem cell-derived retinal pigment epithelial cells |
| US8648069B2 (en) | 2007-06-08 | 2014-02-11 | Abbvie Inc. | 5-substituted indazoles as kinase inhibitors |
| JP2008307007A (ja) | 2007-06-15 | 2008-12-25 | Bayer Schering Pharma Ag | 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞 |
| AU2008272949B2 (en) | 2007-06-29 | 2014-05-15 | FUJIFILM Cellular Dynamics, Inc. | Automated method and apparatus for embryonic stem cell culture |
| US20120282229A1 (en) | 2007-08-01 | 2012-11-08 | Christian Kannemeier | Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state |
| WO2009032194A1 (en) * | 2007-08-31 | 2009-03-12 | Whitehead Institute For Biomedical Research | Wnt pathway stimulation in reprogramming somatic cells |
| AU2008297024B2 (en) | 2007-10-31 | 2014-08-28 | Kyoto University | Nuclear reprogramming method |
| JP4604076B2 (ja) | 2007-11-07 | 2010-12-22 | 国立大学法人静岡大学 | 燃料電池用電解質膜 |
| EP2227540A4 (en) | 2007-11-29 | 2011-11-02 | Children S Hospital Of Orange County | DIFFERENTIATION OF HUMAN CELLS |
| AU2008329563A1 (en) | 2007-11-30 | 2009-06-04 | Cytomatrix Pty Ltd | Methods of inducing pluripotency involving Oct4 protein |
| EP2227241A1 (en) | 2007-11-30 | 2010-09-15 | Cytomatrix PTY LTD | Methods of inducing pluripotency involving sox2 protein |
| WO2009082184A2 (en) | 2007-12-26 | 2009-07-02 | Posdata Co., Ltd. | Method for determining spurious and wireless communication system applying that method |
| JP5951254B2 (ja) | 2008-03-17 | 2016-07-13 | ザ スクリプス リサーチ インスティテュート | 人工多能性幹細胞を作製するための化学的手法と遺伝的手法の組み合わせ法 |
| US8298825B1 (en) | 2008-08-25 | 2012-10-30 | The General Hospital Corporation | TGF-beta receptor inhibitors to enhance direct reprogramming |
| SG172160A1 (en) | 2008-12-17 | 2011-07-28 | Scripps Research Inst | Generation and maintenance of stem cells |
| US20120122212A1 (en) | 2009-03-06 | 2012-05-17 | Marica Grskovic | Tgf-beta pathway inhibitors for enhancement of cellular reprogramming of human cells |
| JP5777113B2 (ja) | 2009-05-29 | 2015-09-09 | 学校法人慶應義塾 | 人工多能性幹細胞のクローンの選択方法 |
| US8900871B2 (en) | 2009-08-07 | 2014-12-02 | Kyoto University | Method of producing induced pluripotent stem cells using inhibitors of P53 |
| MX389666B (es) | 2009-10-16 | 2025-03-19 | Scripps Research Inst | Induccion de celulas pluripotentes. |
| EP2542669B1 (en) | 2010-03-05 | 2015-01-21 | Texas Heart Institute | Ets2 and mesp1 generate cardiac progenitors from fibroblasts |
| CA2800498C (en) | 2010-03-31 | 2021-11-16 | The Scripps Research Institute | Reprogramming cells |
| JO3421B1 (ar) | 2011-06-20 | 2019-10-20 | H Lundbeck As | طريقة لإعطاء 1-((1ار.3س)-6-كلورو-3-فينيل-اندان-1-ايل)-1.2.2-ترايميثيل- بيبيرازين واملاجها لمعالجة انفصام الشخصية |
| US9166832B1 (en) | 2013-10-04 | 2015-10-20 | Altera Corporation | Methods and apparatus for decision feedback equalization adaptation |
-
2009
- 2009-03-17 JP JP2011500906A patent/JP5951254B2/ja active Active
- 2009-03-17 EP EP15177122.7A patent/EP2955222B1/en active Active
- 2009-03-17 EP EP25164709.5A patent/EP4578941A3/en active Pending
- 2009-03-17 SG SG10202103401QA patent/SG10202103401QA/en unknown
- 2009-03-17 CN CN200980117686.XA patent/CN102027105B/zh active Active
- 2009-03-17 SG SG10201808863UA patent/SG10201808863UA/en unknown
- 2009-03-17 MX MX2010010165A patent/MX2010010165A/es not_active Application Discontinuation
- 2009-03-17 CA CA2718904A patent/CA2718904C/en active Active
- 2009-03-17 KR KR1020107023172A patent/KR101679082B1/ko active Active
- 2009-03-17 EP EP09721278.1A patent/EP2279243B1/en active Active
- 2009-03-17 ES ES15177122.7T patent/ES2690554T3/es active Active
- 2009-03-17 SG SG2013019211A patent/SG188904A1/en unknown
- 2009-03-17 US US12/933,391 patent/US9534205B2/en active Active
- 2009-03-17 WO PCT/US2009/037429 patent/WO2009117439A2/en not_active Ceased
- 2009-03-17 EP EP18185585.9A patent/EP3409762A1/en not_active Ceased
- 2009-03-17 AU AU2009225665A patent/AU2009225665B9/en active Active
- 2009-03-17 RU RU2010139426/10A patent/RU2010139426A/ru not_active Application Discontinuation
- 2009-03-17 CN CN201510084514.4A patent/CN104694570B/zh active Active
- 2009-03-17 BR BRPI0908708A patent/BRPI0908708A2/pt not_active IP Right Cessation
- 2009-03-17 SG SG10201607710UA patent/SG10201607710UA/en unknown
-
2010
- 2010-03-12 US US12/723,063 patent/US9068170B2/en active Active
- 2010-04-02 US US12/753,386 patent/US9394524B2/en active Active
- 2010-09-14 IL IL208144A patent/IL208144B/en active IP Right Grant
- 2010-09-17 ZA ZA2010/06683A patent/ZA201006683B/en unknown
-
2013
- 2013-03-14 US US13/831,289 patent/US9540615B2/en active Active
-
2015
- 2015-01-28 JP JP2015013821A patent/JP2015119714A/ja active Pending
-
2016
- 2016-06-10 US US15/179,657 patent/US9771563B2/en active Active
- 2016-08-02 JP JP2016151681A patent/JP6321733B2/ja active Active
- 2016-11-30 US US15/365,823 patent/US9926533B2/en active Active
-
2017
- 2017-08-23 US US15/684,851 patent/US20180002671A1/en not_active Abandoned
-
2018
- 2018-02-08 US US15/892,312 patent/US20180171303A1/en not_active Abandoned
- 2018-04-05 JP JP2018072807A patent/JP6899792B2/ja active Active
-
2021
- 2021-06-15 JP JP2021099098A patent/JP7286710B2/ja active Active
-
2023
- 2023-05-24 JP JP2023085020A patent/JP7642712B2/ja active Active
-
2024
- 2024-11-13 JP JP2024198599A patent/JP2025015628A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| SG10202103401QA (en) | Combined chemical and genetic approaches for generation of induced pluripotent stem cells | |
| GB2458863B (en) | Improved culture of stem cells | |
| ZA201100758B (en) | Differentiation of pluripotent stem cells | |
| SG10201402428WA (en) | Method of efficiently establishing induced pluripotent stem cells | |
| ZA201606403B (en) | Pluripotent stem cell culture on micro-carriers | |
| SG10201608797WA (en) | Method of efficiently establishing induced pluripotent stem cells | |
| PL2046946T3 (pl) | Hodowla pluripotencjalnych komórek macierzystych | |
| PL2356227T3 (pl) | Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych | |
| GB0814249D0 (en) | Uses of mesenchymal stem cells | |
| IL211764A0 (en) | Markers of induced pluripotent stem cells | |
| IL213582A0 (en) | Generation and maintenance of stem cells | |
| ZA201000715B (en) | Single pluripotent stem cell culture | |
| SG10201500674YA (en) | Pluripotent stem cells | |
| SG10201802522SA (en) | Treatment of pluripotent cells | |
| IL223527B (en) | Generation of induced pluripotent stem cells from small volumes of peripheral blood | |
| GB0710095D0 (en) | Culture method of stem cell | |
| IL216902A0 (en) | Methods for culturing stem and progentitor cells | |
| IL214798A0 (en) | Methods and compositions for stem cell cultures | |
| IL221481A0 (en) | Method of efficiently establishing induced pluripotent stem cells | |
| EP2414510A4 (en) | INDUCED PLURIPOTENTIAL STEM CELLS | |
| IL213205A0 (en) | Stem cell cultures | |
| EP2499241B8 (en) | Methods of generating neural stem cells | |
| BRPI0913925A2 (pt) | Diferenciação de células-tronco pluripotentes | |
| IL217063A0 (en) | Generation of induced pluripotent stem cells from cord blood | |
| GB0622394D0 (en) | Differentiation of pluripotent cells |