PL2356227T3 - Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych - Google Patents

Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych

Info

Publication number
PL2356227T3
PL2356227T3 PL09826863T PL09826863T PL2356227T3 PL 2356227 T3 PL2356227 T3 PL 2356227T3 PL 09826863 T PL09826863 T PL 09826863T PL 09826863 T PL09826863 T PL 09826863T PL 2356227 T3 PL2356227 T3 PL 2356227T3
Authority
PL
Poland
Prior art keywords
encapsulation
pluripotent stem
human pluripotent
stem cells
pancreatic
Prior art date
Application number
PL09826863T
Other languages
English (en)
Inventor
Laura Martinson
Chad Green
Evert Kroon
Alan Agulnick
Olivia Kelly
Emmanuel E. Baetge
Original Assignee
Viacyte, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Viacyte, Inc. filed Critical Viacyte, Inc.
Publication of PL2356227T3 publication Critical patent/PL2356227T3/pl

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N1/00Preservation of bodies of humans or animals, or parts thereof
    • A01N1/02Preservation of living parts
    • A01N1/0205Chemical aspects
    • A01N1/021Preservation or perfusion media, liquids, solids or gases used in the preservation of cells, tissue, organs or bodily fluids
    • A01N1/0221Freeze-process protecting agents, i.e. substances protecting cells from effects of the physical process, e.g. cryoprotectants, osmolarity regulators like oncotic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/022Artificial gland structures using bioreactors
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37Digestive system
    • A61K35/39Pancreas; Islets of Langerhans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • A61M31/002Devices for releasing a drug at a continuous and controlled rate for a prolonged period of time
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/48Drugs for disorders of the endocrine system of the pancreatic hormones
    • A61P5/50Drugs for disorders of the endocrine system of the pancreatic hormones for increasing or potentiating the activity of insulin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0676Pancreatic cells
    • C12N5/0678Stem cells; Progenitor cells; Precursor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/126Immunoprotecting barriers, e.g. jackets, diffusion chambers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/62Encapsulated active agents, e.g. emulsified droplets
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64Animal cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00Special media to be introduced, removed or treated
    • A61M2202/07Proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00General characteristics of the apparatus
    • A61M2205/04General characteristics of the apparatus implanted
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M31/00Devices for introducing or retaining media, e.g. remedies, in cavities of the body
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/115Basic fibroblast growth factor (bFGF, FGF-2)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/117Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/119Other fibroblast growth factors, e.g. FGF-4, FGF-8, FGF-10
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/16Activin; Inhibin; Mullerian inhibiting substance
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10Growth factors
    • C12N2501/19Growth and differentiation factors [GDF]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30Hormones
    • C12N2501/38Hormones with nuclear receptors
    • C12N2501/385Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40Regulators of development
    • C12N2501/41Hedgehog proteins; Cyclopamine (inhibitor)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40Regulators of development
    • C12N2501/415Wnt; Frizzeled
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Transplantation (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cell Biology (AREA)
  • Dermatology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Diabetes (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Vascular Medicine (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Botany (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nutrition Science (AREA)
PL09826863T 2008-11-14 2009-11-13 Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych PL2356227T3 (pl)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US11485708P 2008-11-14 2008-11-14
US12108608P 2008-12-09 2008-12-09
EP09826863.4A EP2356227B1 (en) 2008-11-14 2009-11-13 Encapsulation of pancreatic cells derived from human pluripotent stem cells
PCT/US2009/064459 WO2010057039A2 (en) 2008-11-14 2009-11-13 Encapsulation of pancreatic cells derived from human pluripotent stem cells

Publications (1)

Publication Number Publication Date
PL2356227T3 true PL2356227T3 (pl) 2018-07-31

Family

ID=42170745

Family Applications (1)

Application Number Title Priority Date Filing Date
PL09826863T PL2356227T3 (pl) 2008-11-14 2009-11-13 Kapsułkowanie komórek trzustki pochodzących z ludzkich pluripotencjalnych komórek macierzystych

Country Status (9)

Country Link
US (9) US8278106B2 (pl)
EP (3) EP2356227B1 (pl)
JP (6) JP2012508584A (pl)
CN (2) CN102282254B (pl)
AU (1) AU2009313870B2 (pl)
CA (2) CA3229301A1 (pl)
ES (2) ES2932850T3 (pl)
PL (1) PL2356227T3 (pl)
WO (1) WO2010057039A2 (pl)

Families Citing this family (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7432104B2 (en) * 2001-08-06 2008-10-07 Bresgen Inc. Methods for the culture of human embryonic stem cells on human feeder cells
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
EP2610336A1 (en) 2007-07-31 2013-07-03 Lifescan, Inc. Differentiation of human embryonic stem cells
US9062290B2 (en) 2007-11-27 2015-06-23 Lifescan, Inc. Differentiation of human embryonic stem cells
KR20190057164A (ko) 2008-02-21 2019-05-27 얀센 바이오테크 인코포레이티드 세포 부착, 배양 및 탈리를 위한 방법, 표면 개질 플레이트 및 조성물
GB2460842B (en) * 2008-06-10 2011-02-16 Cryogenetics As Packaging for biological material
CA2729121C (en) 2008-06-30 2019-04-09 Centocor Ortho Biotech Inc. Differentiation of pluripotent stem cells
MX2011004563A (es) 2008-10-31 2011-06-01 Centocor Ortho Biotech Inc Diferenciacion de celulas madre embrionarias humanas al linaje endocrino pancreatico.
CA2742268C (en) 2008-10-31 2020-02-18 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
US8895300B2 (en) 2008-11-04 2014-11-25 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
US8008075B2 (en) * 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
CN102282254B (zh) 2008-11-14 2015-12-16 维赛特公司 源于人多能干细胞的胰腺细胞的包封
KR101837080B1 (ko) 2008-11-20 2018-03-09 얀센 바이오테크 인코포레이티드 마이크로-캐리어 상의 만능 줄기 세포 배양
CA2744227C (en) 2008-11-20 2018-10-02 Centocor Ortho Biotech Inc. Methods and compositions for cell attachment and cultivation on planar substrates
US9109245B2 (en) 2009-04-22 2015-08-18 Viacyte, Inc. Cell compositions derived from dedifferentiated reprogrammed cells
KR102058901B1 (ko) * 2009-07-20 2019-12-24 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
SG10202001012VA (en) 2009-08-28 2020-04-29 Sernova Corp Device for cellular transplantation and uses thereof
US20120321595A1 (en) 2009-11-09 2012-12-20 The Brigham And Women's Hospital, Inc. Treatment of heart disease
WO2011079017A2 (en) 2009-12-23 2011-06-30 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells
US8455242B2 (en) 2010-02-22 2013-06-04 Hyclone Laboratories, Inc. Mixing system with condenser
EP2542667A4 (en) 2010-03-01 2013-07-31 Janssen Biotech Inc PROCESS FOR CLEANING CELLS OBTAINED FROM PLURIPOTENTIAL STEM CELLS
KR101903562B1 (ko) 2010-05-12 2018-10-02 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
EP2604685B1 (en) * 2010-08-09 2017-03-15 Takeda Pharmaceutical Company Limited Method of producing pancreatic hormone-producing cells
AU2015213422A1 (en) * 2010-08-12 2015-09-10 Janssen Biotech, Inc. Treatment of diabetes with pancreatic endocrine precursor cells
RU2013110524A (ru) * 2010-08-12 2014-09-20 Янссен Байотек, Инк. Лечение диабета при помощи панкреатических эндокринных клеток-предшественников
US9475709B2 (en) 2010-08-25 2016-10-25 Lockheed Martin Corporation Perforated graphene deionization or desalination
CN103154239B (zh) 2010-08-31 2018-05-15 詹森生物科技公司 人胚胎干细胞的分化
US9181528B2 (en) 2010-08-31 2015-11-10 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
EP2611909B1 (en) 2010-08-31 2018-01-17 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
AU2011307663B2 (en) * 2010-09-27 2015-05-07 Gloriana Therapeutics Sarl Implantable cell device with supportive and radial diffusive scaffolding
MX2010013135A (es) * 2010-11-30 2012-05-31 Val De Bio S De R L De C V Procedimiento y dispositivo mejorados para favorecer el trasplante de material biológico.
WO2012115619A1 (en) 2011-02-21 2012-08-30 Viacyte, Inc. Loading system for an encapsulation device
ES2902650T3 (es) 2011-06-21 2022-03-29 Novo Nordisk As Inducción eficiente de endodermo definitivo a partir de células madre pluripotentes
CN102550542B (zh) * 2011-08-09 2014-06-25 臻景生物技术(上海)有限公司 用于脂肪干细胞的无血清冻存液及脂肪干细胞库的建立
US20140242038A1 (en) * 2011-10-11 2014-08-28 The Trustees Of Columbia University In The City Of New York Method for generating beta cells
USD728095S1 (en) * 2011-12-12 2015-04-28 Viacyte, Inc. Cell encapsulation device
USD726307S1 (en) * 2011-12-12 2015-04-07 Viacyte Inc. Cell encapsulation device
USD726306S1 (en) * 2011-12-12 2015-04-07 Viacyte, Inc. Cell encapsulation device
CN105143446B (zh) 2011-12-22 2020-11-03 詹森生物科技公司 人胚胎干细胞分化成单一激素胰岛素阳性细胞
CN104160018A (zh) 2012-03-07 2014-11-19 詹森生物科技公司 用于扩增和维持多能干细胞的成分确定的培养基
US9610546B2 (en) 2014-03-12 2017-04-04 Lockheed Martin Corporation Separation membranes formed from perforated graphene and methods for use thereof
US10696554B2 (en) 2015-08-06 2020-06-30 Lockheed Martin Corporation Nanoparticle modification and perforation of graphene
US9834809B2 (en) 2014-02-28 2017-12-05 Lockheed Martin Corporation Syringe for obtaining nano-sized materials for selective assays and related methods of use
US10980919B2 (en) 2016-04-14 2021-04-20 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
US10653824B2 (en) 2012-05-25 2020-05-19 Lockheed Martin Corporation Two-dimensional materials and uses thereof
US9744617B2 (en) 2014-01-31 2017-08-29 Lockheed Martin Corporation Methods for perforating multi-layer graphene through ion bombardment
USD734847S1 (en) * 2012-05-31 2015-07-21 Viacyte, Inc. Cell encapsulation device
RU2018108850A (ru) 2012-06-08 2019-02-26 Янссен Байотек, Инк. Дифференцировка эмбриональных стволовых клеток человека в панкреатические эндокринные клетки
US20150320836A1 (en) * 2012-07-06 2015-11-12 The Regents Of The University Of California Cryopreservation of cells inside a macro-encapsulation device
US20150247123A1 (en) 2012-09-03 2015-09-03 Novo Nordisk A/S Generation of pancreatic endoderm from Pluripotent Stem cells using small molecules
AU2013248265B2 (en) 2012-11-08 2018-11-01 Viacyte, Inc. Scalable primate pluripotent stem cell aggregate suspension culture and differentiation thereof
WO2014106141A1 (en) 2012-12-31 2014-07-03 Janssen Biotech, Inc. Suspension and clustering of human pluripotent cells for differentiation into pancreatic endocrine cells
US10138465B2 (en) 2012-12-31 2018-11-27 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endocrine cells using HB9 regulators
DK2938724T3 (da) 2012-12-31 2020-12-14 Janssen Biotech Inc Dyrkning af humane embryonale stamceller ved luft-væskegrænsefladen til differentiering til endokrine pankreasceller
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
IL311689A (en) * 2013-02-06 2024-05-01 Viacyte Inc Cell preparations derived from dedifferentiated and reprogrammed cells
US20150368616A1 (en) * 2013-02-14 2015-12-24 The Cleveland Clinic Foundation Methods for induction of cell fates from pluripotent cells
USD720469S1 (en) 2013-03-07 2014-12-30 Viacyte, Inc. Cell encapsulation device
JP6234485B2 (ja) 2013-03-07 2017-11-22 ヴィアサイト インコーポレイテッド 3次元大収容力細胞封入デバイスアセンブリー
WO2014138671A2 (en) 2013-03-08 2014-09-12 Viacyte, Inc. Cryopreservation, hibernation and room temperature storage of encapulated pancreatic endoderm cell aggregates
WO2014164621A1 (en) 2013-03-12 2014-10-09 Lockheed Martin Corporation Method for forming filter with uniform aperture size
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
JP6325649B2 (ja) * 2013-04-24 2018-05-16 ネステク ソシエテ アノニム カプセル化デバイス
EP3569694A1 (en) 2013-06-11 2019-11-20 President and Fellows of Harvard College Sc-beta cells and compositions and methods for generating the same
US9572918B2 (en) 2013-06-21 2017-02-21 Lockheed Martin Corporation Graphene-based filter for isolating a substance from blood
AU2014286177B2 (en) 2013-07-02 2018-01-18 Austrianova Singapore Pte Ltd. A method of freeze-drying encapsulated cells, freeze-dried encapsulated cells, compositions containing freeze-dried encapsulated cells and uses of such cells and compositions
CA2924681C (en) 2013-09-24 2019-12-31 Giner, Inc. System for gas treatment of a cell implant
WO2015116857A2 (en) 2014-01-31 2015-08-06 Lockheed Martin Corporation Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer
KR20160142820A (ko) 2014-01-31 2016-12-13 록히드 마틴 코포레이션 브로드 이온 필드를 사용한 2차원 물질 천공
SG11201607584PA (en) * 2014-03-12 2016-10-28 Lockheed Corp In vivo and in vitro use of graphene
JP2017512129A (ja) 2014-03-12 2017-05-18 ロッキード・マーチン・コーポレーション 有孔グラフェンから形成された分離膜
KR102454662B1 (ko) 2014-03-21 2022-10-14 라이프 테크놀로지스 코포레이션 유체 처리 시스템을 위한 냉각 시스템
CN106232219B (zh) 2014-03-21 2020-04-24 生命科技股份有限公司 用于流体处理系统的气体过滤器系统
US9950151B2 (en) * 2014-03-27 2018-04-24 Beta-O2 Technologies Ltd. Implantable medical devices
USD760399S1 (en) * 2014-04-16 2016-06-28 Viacyte, Inc. Case for an encapsulation device
US11051900B2 (en) * 2014-04-16 2021-07-06 Viacyte, Inc. Tools and instruments for use with implantable encapsulation devices
EP4289467A3 (en) 2014-04-16 2024-02-21 ViaCyte, Inc. Instruments for use with implantable encapsulation devices
WO2015175776A1 (en) * 2014-05-14 2015-11-19 NuTech Medical, Inc. Placental membrane preparations and methods of making and using same for regenerating cartilage and spinal intervertebral discs
JP6588969B2 (ja) 2014-05-16 2019-10-09 ヤンセン バイオテツク,インコーポレーテツド 膵内分泌細胞内のmafa発現を強化するための小分子の使用
WO2015178431A1 (ja) * 2014-05-21 2015-11-26 国立大学法人京都大学 膵芽細胞の製造方法および膵芽細胞を含む膵疾患治療剤
EP3180044B1 (en) 2014-06-09 2020-08-05 Cornell University Implantable therapeutic delivery system and methods thereof
SG11201701654UA (en) 2014-09-02 2017-04-27 Lockheed Corp Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same
CN107614678B (zh) * 2014-12-18 2021-04-30 哈佛学院校长同事会 干细胞来源的β细胞的产生方法及其使用方法
EP3234110B1 (en) 2014-12-18 2024-02-28 President and Fellows of Harvard College METHODS FOR GENERATING STEM CELL-DERIVED ß CELLS AND USES THEREOF
US10443042B2 (en) 2014-12-18 2019-10-15 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived beta cells and uses thereof
WO2016154333A1 (en) 2015-03-23 2016-09-29 The Regents Of The University Of California Thin film cell encapsulation devices
DK3286300T3 (da) 2015-04-24 2021-01-18 Univ Copenhagen Isolering af bona fide pankreatiske stamceller
WO2017023376A1 (en) 2015-08-05 2017-02-09 Lockheed Martin Corporation Perforatable sheets of graphene-based material
WO2017049008A1 (en) * 2015-09-16 2017-03-23 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
EP3167911A1 (en) * 2015-11-10 2017-05-17 Oniris Si-hpmc-encapsulated insulin-producing cells for the treatment of type 1 diabetes
CN108778515B (zh) * 2015-12-29 2020-11-17 生命科技股份有限公司 具有部分分割分隔区的柔性生物处理容器
US11613732B2 (en) 2016-01-12 2023-03-28 StemoniX Inc. Cell medium formulation for cell stabilization
US11534466B2 (en) 2016-03-09 2022-12-27 Aal Scientifics, Inc. Pancreatic stem cells and uses thereof
WO2017165850A1 (en) * 2016-03-25 2017-09-28 Lockheed Martin Corporation Methods for in vivo and in vitro use of graphene and other two-dimensional materials
CA3020880A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Selective interfacial mitigation of graphene defects
EP3442786A4 (en) 2016-04-14 2020-03-18 Lockheed Martin Corporation TWO-DIMENSIONAL MEMBRANE STRUCTURES HAVING FLOW PASSAGES
SG11201808961QA (en) 2016-04-14 2018-11-29 Lockheed Corp Methods for in situ monitoring and control of defect formation or healing
MA45479A (fr) 2016-04-14 2019-02-20 Janssen Biotech Inc Différenciation de cellules souches pluripotentes en cellules de l'endoderme de l'intestin moyen
WO2017180135A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Membranes with tunable selectivity
CA3020686A1 (en) 2016-04-14 2017-10-19 Lockheed Martin Corporation Method for treating graphene sheets for large-scale transfer using free-float method
EP3484997A4 (en) * 2016-07-12 2020-07-29 California Institute of Technology SUBSTRATES FOR HIGH-DENSITY CELL GROWTH AND METABOLITE EXCHANGE
US20200054257A1 (en) * 2016-11-03 2020-02-20 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods, systems, and implantable devices for enhancing blood glucose regulation
SG10202104562TA (en) 2016-11-03 2021-06-29 Univ Arizona Stacked tissue encapsulation device systems with or without oxygen delivery
AU2017355528B2 (en) 2016-11-03 2021-04-01 Arizona Board Of Regents On Behalf Of The University Of Arizona Encapsulation device systems with oxygen sensors with or without exogenous oxygen delivery
WO2018144099A1 (en) 2016-11-03 2018-08-09 The Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for real-time assessment of cells in encapsulation devices pre-and post-transplantation
US11052230B2 (en) * 2016-11-08 2021-07-06 W. L. Gore & Associates, Inc. Implantable encapsulation devices
US10849731B2 (en) * 2016-11-08 2020-12-01 W. L. Gore & Associates, Inc. Cell encapsulation devices containing structural spacers
EP3537986A4 (en) * 2016-11-10 2020-06-03 ViaCyte, Inc. PANCREATIC ENDODERM CELLS PDX1 IN CELL DELIVERY DEVICES AND RELATED METHODS
USD824042S1 (en) 2016-11-10 2018-07-24 Viacyte, Inc. Perforated cell encapsulation device
BR112019009761A2 (pt) 2016-11-15 2019-08-13 Giner Life Sciences Inc autorregulação de gerador de gás eletrolítico e sistema de implante compreendendo o mesmo
US11033666B2 (en) 2016-11-15 2021-06-15 Giner Life Sciences, Inc. Percutaneous gas diffusion device suitable for use with a subcutaneous implant
CN108148808B (zh) * 2016-12-05 2020-12-11 同济大学 有助于诱导生成神经前体细胞的诱导培养基
JPWO2018159805A1 (ja) * 2017-03-03 2020-01-09 国立大学法人京都大学 膵前駆細胞の製造方法
US12016327B2 (en) 2017-03-20 2024-06-25 Boston Scientific Medical Device Limited Cell encapsulation device
US11642501B2 (en) 2017-05-04 2023-05-09 Giner, Inc. Robust, implantable gas delivery device and methods, systems and devices including same
EP3409239A1 (en) * 2017-05-29 2018-12-05 University College Dublin, National University of Ireland, Dublin An implantable active agent encapsulating device
CA3066055A1 (en) 2017-06-14 2018-12-20 Semma Therapeutics, Inc. Devices and methods for delivering therapeutics
US20200208093A1 (en) * 2017-06-14 2020-07-02 Takeda Pharmaceutical Company Limited Cell-sealing device
KR102001120B1 (ko) 2017-06-29 2019-07-16 서울대학교산학협력단 나노섬유 및 하이드로젤의 복합체 및 이를 포함하는 조직 재생용 스캐폴드
US10391156B2 (en) 2017-07-12 2019-08-27 Viacyte, Inc. University donor cells and related methods
WO2019044990A1 (ja) 2017-08-30 2019-03-07 富士フイルム株式会社 細胞移植用デバイスおよびその製造方法
JP6854904B2 (ja) * 2017-08-30 2021-04-07 富士フイルム株式会社 血管新生剤およびその製造方法
MA50279A (fr) * 2017-09-11 2020-07-22 Novo Nordisk As Enrichissement de cellules coexprimant nkx6.1 et le peptide c, dérivées in vitro à partir de cellules souches
US11951206B2 (en) 2017-09-29 2024-04-09 Vertex Pharmaceuticals Incorporated Cell housing device
CA2983845C (en) 2017-10-26 2024-01-30 University Of Copenhagen Generation of glucose-responsive beta cells
JP7428653B2 (ja) 2017-11-15 2024-02-06 バーテックス ファーマシューティカルズ インコーポレイテッド 島細胞製造組成物および使用方法
JP2019097442A (ja) 2017-11-30 2019-06-24 株式会社日立製作所 免疫隔離デバイス
JP6417023B2 (ja) * 2017-12-20 2018-10-31 ネステク ソシエテ アノニム カプセル化デバイス
CN108543116B (zh) * 2018-05-02 2021-04-27 深圳市华异生物科技有限责任公司 海藻酸钠与明胶复合水凝胶3d胰岛支架及其制备方法
WO2019222704A1 (en) 2018-05-17 2019-11-21 Giner Life Sciences, Inc. Electrolytic gas generator with combined lead and gas port terminals
JP7370600B2 (ja) * 2018-08-03 2023-10-30 オリヅルセラピューティクス株式会社 細胞製造法
EP3833365A4 (en) 2018-08-10 2022-05-11 Vertex Pharmaceuticals Incorporated ISLE DIFFERENTIATION DERIVED FROM STEM CELLS
CN112654331A (zh) * 2018-08-22 2021-04-13 波士顿科学国际有限公司 包括多孔管的细胞包封装置
EP3843545A4 (en) * 2018-08-30 2021-11-17 The Curators Of The University Of Missouri EFFICIENT CRYOPRESERVATION DEVICE TO PREVENT DIRECT CONTACT BETWEEN SAMPLES AND EXTRACELLULAR ICE
US20200080107A1 (en) 2018-09-07 2020-03-12 Crispr Therapeutics Ag Universal donor cells
US20210401564A1 (en) * 2018-09-24 2021-12-30 Arizona Board Regents On Behalf Of The University Of Arizona Methods and systems for implantable medical devices and vascularization membranes
US20210315682A1 (en) * 2018-09-26 2021-10-14 W. L. Gore & Associates, Inc. Cell Encapsulation Devices With Controlled Cell Bed Thickness
UY38389A (es) 2018-09-27 2020-04-30 Sigilon Therapeutics Inc Dispositivos implantables para terapia celular y métodos relacionados
CA3116184A1 (en) * 2018-10-15 2020-04-23 Cynity Co., Ltd. Method for producing stem/precursor cells, by using low molecular weight compound, from cells derived from endodermal tissue or organ
CN109289090A (zh) * 2018-10-31 2019-02-01 陈津 一种胰岛移植微环境及其构建方法
WO2020138028A1 (ja) * 2018-12-25 2020-07-02 富士フイルム株式会社 細胞移植キット、袋状構造物の製造方法、および糖尿病治療剤
JP6970245B2 (ja) * 2019-02-25 2021-11-24 ヴィアサイト インコーポレイテッド 埋め込み可能な封入デバイスと共に使用するツールおよび器具
JP7267377B2 (ja) * 2019-02-25 2023-05-01 ヴィアサイト インコーポレイテッド 埋め込み可能な封入デバイスと共に使用するツールおよび器具
AU2020256224A1 (en) * 2019-04-03 2021-11-11 Vertex Pharmaceuticals Incorporated Multicompartment macroencapsulation devices
CN114173837A (zh) * 2019-05-31 2022-03-11 W.L.戈尔及同仁股份有限公司 生物相容性膜复合材料
CN114401752B (zh) 2019-05-31 2023-04-04 W.L.戈尔及同仁股份有限公司 具有受控氧扩散距离的细胞封装装置
WO2020243663A1 (en) 2019-05-31 2020-12-03 W. L. Gore & Associates, Inc. A biocompatible membrane composite
WO2020243666A1 (en) 2019-05-31 2020-12-03 W. L. Gore & Associates, Inc. A biocompatible membrane composite
CA3150233A1 (en) 2019-09-05 2021-03-11 Alireza Rezania UNIVERSAL DONOR CELLS
CA3150235A1 (en) 2019-09-05 2021-03-11 Alireza Rezania UNIVERSAL DONOR CELLS
KR20220070474A (ko) * 2019-09-27 2022-05-31 이슬라 테크놀로지스, 인크. 생체인공 췌장
WO2022047543A1 (en) * 2020-09-04 2022-03-10 Captix Biomedical Pty Ltd "bone implant"
AU2021372247A1 (en) * 2020-10-30 2023-06-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Methods and systems for encapsulation devices for housing cells and agents
CN112544613B (zh) * 2020-12-25 2022-08-16 武汉睿健医药科技有限公司 一种多能干细胞冻存液、其应用及冻存方法
US11566230B2 (en) 2020-12-31 2023-01-31 Crispr Therapeutics Ag Universal donor cells
KR20240056514A (ko) * 2021-08-10 2024-04-30 위니베르시테이트 마스트리흐트 개방형의 이식 가능한 세포 전달 장치
WO2023164171A2 (en) 2022-02-25 2023-08-31 Viacyte, Inc. Multilayer implantable cell encapsulation devices and methods thereof
WO2023203208A1 (en) 2022-04-21 2023-10-26 Evotec International Gmbh New cell populations and means and methods for their differentiation and preservation
WO2024073711A1 (en) 2022-09-30 2024-04-04 W.L. Gore & Associates, Inc. Implantable membrane construct and encapsulaton devices incorporating the same
WO2024081309A1 (en) 2022-10-11 2024-04-18 Sigilon Therapeutics, Inc. Engineered cells and implantable elements for treatment of disease
WO2024081310A1 (en) 2022-10-11 2024-04-18 Sigilon Therapeutics, Inc. Engineered cells and implantable elements for treatment of disease
JP7451818B1 (ja) 2023-11-10 2024-03-18 洋之 高尾 Diffusion Chamber型人工膵島器

Family Cites Families (162)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2500388A (en) 1948-07-21 1950-03-14 Minnesota Mining & Mfg Fluorocarbon ethers
US2594272A (en) 1948-09-10 1952-04-29 Minnesota Mining & Mfg Cyclic fluoroalkylene oxide compounds
US2519983A (en) 1948-11-29 1950-08-22 Minnesota Mining & Mfg Electrochemical process of making fluorine-containing carbon compounds
US2616927A (en) 1950-05-12 1952-11-04 Minnesota Mining & Mfg Fluorocarbon tertiary amines
US4298002A (en) * 1979-09-10 1981-11-03 National Patent Development Corporation Porous hydrophilic materials, chambers therefrom, and devices comprising such chambers and biologically active tissue and methods of preparation
US4542104A (en) 1983-04-06 1985-09-17 The Board Of Trustees Of The Leland Stanford Jr. Univ. Phycobiliprotein fluorescent conjugates
US4723953A (en) * 1985-01-07 1988-02-09 Rocky Mountain Medical Corporation Absorbent pad
US4788339A (en) 1985-09-06 1988-11-29 Minnesota Mining And Manufacturing Company Perfluoroaminoethers
US5026365A (en) 1987-04-29 1991-06-25 The University Of Massachusetts Method and apparatus for therapeutically treating immunological disorders and disease states
US5182111A (en) 1987-11-17 1993-01-26 Boston University Research Foundation In vivo delivery of active factors by co-cultured cell implants
US5418154A (en) 1987-11-17 1995-05-23 Brown University Research Foundation Method of preparing elongated seamless capsules containing biological material
US5158881A (en) * 1987-11-17 1992-10-27 Brown University Research Foundation Method and system for encapsulating cells in a tubular extrudate in separate cell compartments
US5106627A (en) * 1987-11-17 1992-04-21 Brown University Research Foundation Neurological therapy devices
US5283187A (en) 1987-11-17 1994-02-01 Brown University Research Foundation Cell culture-containing tubular capsule produced by co-extrusion
US5011494A (en) 1988-09-16 1991-04-30 Clemson University Soft tissue implant with micron-scale surface texture to optimize anchorage
US5219361A (en) 1988-09-16 1993-06-15 Clemson University Soft tissue implant with micron-scale surface texture to optimize anchorage
CA1335181C (en) 1988-10-11 1995-04-11 R. Alan Hardwick System for selective cell separation from cell concentrate
WO1990007380A2 (en) 1988-12-28 1990-07-12 Stefan Miltenyi Methods and materials for high gradient magnetic separation of biological materials
US5002661A (en) 1989-08-25 1991-03-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device
US5116493A (en) 1989-08-25 1992-05-26 W. R. Grace & Co.-Conn. Artificial pancreatic perfusion device with reseedable matrix
US5100392A (en) 1989-12-08 1992-03-31 Biosynthesis, Inc. Implantable device for administration of drugs or other liquid solutions
US5171846A (en) 1990-05-21 1992-12-15 Coulter Corporation Method of preferential labelling of a phycobiliprotein with a second dye for use in a multiple color assay and product for such use
US5272257A (en) 1990-05-21 1993-12-21 Coulter Corporation Method of preferential labelling of a phycobiliprotein with an amine-reactive dye for use in a multiple color assay and product for such use
US5240640A (en) 1990-06-04 1993-08-31 Coulter Corporation In situ use of gelatin or an aminodextran in the preparation of uniform ferrite particles
US5529914A (en) 1990-10-15 1996-06-25 The Board Of Regents The Univeristy Of Texas System Gels for encapsulation of biological materials
US5545223A (en) 1990-10-31 1996-08-13 Baxter International, Inc. Ported tissue implant systems and methods of using same
US5466609A (en) 1990-10-31 1995-11-14 Coulter Corporation Biodegradable gelatin-aminodextran particle coatings of and processes for making same
US5713888A (en) 1990-10-31 1998-02-03 Baxter International, Inc. Tissue implant systems
US5314471A (en) 1991-07-24 1994-05-24 Baxter International Inc. Tissue inplant systems and methods for sustaining viable high cell densities within a host
WO1992007525A1 (en) 1990-10-31 1992-05-14 Baxter International Inc. Close vascularization implant material
US5639620A (en) 1990-10-31 1997-06-17 Coulter Corporation Polymeric particles having a biodegradable gelatin or aminodextran coating and process for making same
US5344454A (en) 1991-07-24 1994-09-06 Baxter International Inc. Closed porous chambers for implanting tissue in a host
EP0523949B1 (en) 1991-07-15 2003-06-25 The Wellcome Foundation Limited Production of antibodies
US6773458B1 (en) 1991-07-24 2004-08-10 Baxter International Inc. Angiogenic tissue implant systems and methods
US5453278A (en) 1991-07-24 1995-09-26 Baxter International Inc. Laminated barriers for tissue implants
JPH06502577A (ja) 1991-07-30 1994-03-24 バクスター、インターナショナル、インコーポレイテッド 有孔埋め込み物
JPH0613739Y2 (ja) * 1991-09-26 1994-04-13 富士システムズ株式会社 人工臓器用カプセル及び人工臓器
US5248772A (en) 1992-01-29 1993-09-28 Coulter Corporation Formation of colloidal metal dispersions using aminodextrans as reductants and protective agents
US6165993A (en) 1992-03-23 2000-12-26 University Of Massachusetts Medical Center DNA vaccines against rotavirus infections
WO1993021902A1 (en) * 1992-04-24 1993-11-11 Somatix Therapy Corporation Biocompatible, therapeutic, implantable device
US5690926A (en) 1992-10-08 1997-11-25 Vanderbilt University Pluripotential embryonic cells and methods of making same
US7153684B1 (en) 1992-10-08 2006-12-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5453357A (en) 1992-10-08 1995-09-26 Vanderbilt University Pluripotential embryonic stem cells and methods of making same
US5262055A (en) 1992-10-19 1993-11-16 The University Of Utah Implantable and refillable biohybrid artificial pancreas
US5593972A (en) 1993-01-26 1997-01-14 The Wistar Institute Genetic immunization
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
DE69433087T2 (de) 1993-06-11 2004-06-09 Coulter International Corp., Miami Anti-cd3-antikörper-aminodextran-konjugate zur induktion der t-zellen-aktivierung und vermehrung
WO1995001203A2 (en) * 1993-06-23 1995-01-12 Cytotherapeutics, Inc. Implantable membrane encapsulation apparatus
JPH08503715A (ja) 1993-09-24 1996-04-23 バクスター、インターナショナル、インコーポレイテッド 埋め込み装置の血管化を促進するための方法
US6015671A (en) 1995-06-07 2000-01-18 Indiana University Foundation Myocardial grafts and cellular compositions
US5421923A (en) 1993-12-03 1995-06-06 Baxter International, Inc. Ultrasonic welding horn with sonics dampening insert
US5549675A (en) * 1994-01-11 1996-08-27 Baxter International, Inc. Method for implanting tissue in a host
US6156305A (en) 1994-07-08 2000-12-05 Baxter International Inc. Implanted tumor cells for the prevention and treatment of cancer
US5989833A (en) 1994-09-20 1999-11-23 Institut National De La Sante Et De La Recherche Medicale (Inserm) Methods for detection of molecules with affinity for MPL polypeptides
US5807406A (en) 1994-10-07 1998-09-15 Baxter International Inc. Porous microfabricated polymer membrane structures
US5874301A (en) 1994-11-21 1999-02-23 National Jewish Center For Immunology And Respiratory Medicine Embryonic cell populations and methods to isolate such populations
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5705059A (en) 1995-02-27 1998-01-06 Miltenyi; Stefan Magnetic separation apparatus
WO1996032076A1 (en) 1995-04-11 1996-10-17 Baxter Internatonal Inc. Tissue implant systems
US6060640A (en) 1995-05-19 2000-05-09 Baxter International Inc. Multiple-layer, formed-in-place immunoisolation membrane structures for implantation of cells in host tissue
CA2190628C (en) 1995-06-07 2000-05-30 Mark D. Butler An implantable containment apparatus for a therapeutical device and method for loading and reloading the device therein
WO1997010807A1 (en) 1995-09-22 1997-03-27 Gore Hybrid Technologies, Inc. Improved cell encapsulation device
EP0885308A4 (en) 1996-02-28 2002-02-27 Univ Vanderbilt CONNECTIONS AND METHODS FOR THE PRODUCTION OF EMBRYONIC STEM CELLS
US5964261A (en) * 1996-05-29 1999-10-12 Baxter International Inc. Implantation assembly
AU5734998A (en) 1997-01-10 1998-08-03 Life Technologies, Inc. Embryonic stem cell serum replacement
US6090622A (en) 1997-03-31 2000-07-18 The Johns Hopkins School Of Medicine Human embryonic pluripotent germ cells
US6261281B1 (en) 1997-04-03 2001-07-17 Electrofect As Method for genetic immunization and introduction of molecules into skeletal muscle and immune cells
BR9813202B1 (pt) 1997-09-15 2011-11-01 complexo de administração de genes; processo de transdução de células com material genético estranho, composição útil para administração de material genético e uso de um complexo de administração de genes.
US5945293A (en) 1997-10-09 1999-08-31 Coulter International Corp. Protein-colloidal metal-aminodextran coated particle and methods of preparation and use
US6074884A (en) 1997-10-09 2000-06-13 Coulter International Corp. Stable protein-nickel particles and methods of production and use thereof
WO1999020741A1 (en) 1997-10-23 1999-04-29 Geron Corporation Methods and materials for the growth of primate-derived primordial stem cells
WO1999053021A1 (en) 1998-04-09 1999-10-21 Bresagen Limited Cell differentiation/proliferation and maintenance factor and uses thereof
US6921811B2 (en) 1998-09-22 2005-07-26 Biosurface Engineering Technologies, Inc. Bioactive coating composition and methods
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
DE19852800C1 (de) 1998-11-16 2000-04-13 Univ Albert Ludwigs Freiburg Verfahren zur Herstellung von Antikörpern gegen ein Polypeptid, von dem die kodierende Nukleinsäure bekannt ist
CA2355675C (en) * 1998-12-15 2006-07-04 Universidad Nacional Autonoma De Mexico Process and device for facilitating the implantation of biological material
EP1175487A2 (en) * 1999-02-10 2002-01-30 Curis, Inc. Pancreatic progenitor cells, methods and uses related thereto
US6365385B1 (en) * 1999-03-22 2002-04-02 Duke University Methods of culturing and encapsulating pancreatic islet cells
US6872389B1 (en) 1999-07-08 2005-03-29 Rhode Island Hospital Liver stem cell
US6520997B1 (en) 1999-12-08 2003-02-18 Baxter International Inc. Porous three dimensional structure
US6617151B1 (en) * 2000-02-29 2003-09-09 Gore Enterprise Holdings, Inc. Method of closing a cell containment device with a wet seal
US7005252B1 (en) 2000-03-09 2006-02-28 Wisconsin Alumni Research Foundation Serum free cultivation of primate embryonic stem cells
US6436704B1 (en) * 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
US7256042B2 (en) 2000-04-27 2007-08-14 Geron Corporation Process for making hepatocytes from pluripotent stem cells
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
JP2004504834A (ja) 2000-08-01 2004-02-19 イスム リサーチ ディベロップメント カンパニー 胚性細胞の定方向分化
WO2002034880A2 (en) 2000-10-23 2002-05-02 University Of Kansas Cadherin peptides for drug delivery and inhibition of tumor metastasis/invasion
JP2005501573A (ja) * 2000-12-01 2005-01-20 ネフロス セラピューティクス, インコーポレイテッド 血管内薬物送達デバイスおよびその使用
US6616912B2 (en) 2001-01-05 2003-09-09 Spectrum Laboratories, Inc. Bi-component microporous hollow fiber membrane structure for in vivo propagation of cells
JP2005503759A (ja) 2001-01-24 2005-02-10 アメリカ合衆国 幹細胞の膵臓内分泌細胞への分化方法
CA2450720A1 (en) 2001-06-13 2002-12-19 Massachusetts Institute Of Technology In vivo bioreactors
US6702857B2 (en) * 2001-07-27 2004-03-09 Dexcom, Inc. Membrane for use with implantable devices
US7432104B2 (en) 2001-08-06 2008-10-07 Bresgen Inc. Methods for the culture of human embryonic stem cells on human feeder cells
EP1298201A1 (en) 2001-09-27 2003-04-02 Cardion AG Process for the production of cells exhibiting an islet-beta-cell-like state
WO2003048336A2 (en) * 2001-12-04 2003-06-12 Organogenesis Inc. Cultured cells from pancreatic islets
US7157278B2 (en) 2001-12-04 2007-01-02 Organogenesis, Inc. Cultured cells from pancreatic islets
US7033831B2 (en) 2001-12-07 2006-04-25 Geron Corporation Islet cells from human embryonic stem cells
US20030138949A1 (en) 2001-12-12 2003-07-24 Anil Bhushan Methods for the regeneration of pancreatic islets and expansion of pancreatic endocrine cells
US7101546B2 (en) * 2001-12-21 2006-09-05 Amcyte, Inc. In situ maturation of cultured pancreatic stem cells having a specified, intermediate stage of development
JP2006513727A (ja) 2002-05-17 2006-04-27 マウント シナイ スクール オブ メディスン オブ ニューヨーク ユニバーシティー 中胚葉および成体型内胚葉細胞集団
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
EP1507552A2 (en) 2002-05-28 2005-02-23 Novocell, Inc. Methods, compositions, and growth and differentiation factors for insulin-producing cells
CN1662643A (zh) 2002-05-28 2005-08-31 贝克顿·迪金森公司 人腺泡细胞的扩增和转分化
WO2004032881A2 (en) 2002-10-11 2004-04-22 Novocell, Inc. Implantation of encapsulated biological materials for treating diseases
AU2003302702B2 (en) 2002-12-05 2008-08-07 Technion Research & Development Foundation Ltd. Cultured human pancreatic islets, and uses thereof
KR20050096974A (ko) 2003-02-07 2005-10-06 위스콘신 얼럼나이 리서어치 화운데이션 인간 줄기 세포의 지시된 유전적 변형
WO2005045001A2 (en) 2003-02-14 2005-05-19 The Board Of Trustees Of The Leland Stanford Junior University Insulin-producing cells derived from stem cells
US20030224411A1 (en) 2003-03-13 2003-12-04 Stanton Lawrence W. Genes that are up- or down-regulated during differentiation of human embryonic stem cells
US20040229350A1 (en) 2003-05-12 2004-11-18 Nikolai Strelchenko Morula derived embryonic stem cells
US20060281136A1 (en) 2003-05-20 2006-12-14 Shinichi Nishikawa Preparation of endodermal stem cells
WO2005017131A2 (en) 2003-08-14 2005-02-24 THE GOUVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT F HEALTH AND HUMAN SERVICES Methods for the differentiation of human stem cells
EP1670900A4 (en) 2003-08-27 2008-06-11 Stemcells California Inc ENHANCED PANCREATIC STEM CELL AND PRECURSOR CELL POPULATIONS AND METHOD OF IDENTIFYING, INSULATING AND ENRICHING SUCH POPULATIONS
US20050170502A1 (en) 2003-09-30 2005-08-04 Regents Of The University Of California Methods for maintaining hepatocytes in culture and for differentiating embryonic stem cells along a hepatocyte lineage
WO2005059095A2 (en) * 2003-12-10 2005-06-30 The General Hospital Corporation Expansion and differentiation of islet progenitor cells
US7985585B2 (en) 2004-07-09 2011-07-26 Viacyte, Inc. Preprimitive streak and mesendoderm cells
MX2009009225A (es) 2003-12-23 2009-09-28 Cythera Inc Endodermo definitivo.
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
WO2007059007A2 (en) 2005-11-14 2007-05-24 Cythera, Inc. Markers of definitive endoderm
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US20050191282A1 (en) * 2004-03-01 2005-09-01 Opara Emmanuel C. Method of cryopreserving pancreatic islet cells
JP2008500809A (ja) * 2004-03-09 2008-01-17 ライフスキャン・インコーポレイテッド インスリン産生細胞を発生させるための方法
WO2005097980A2 (en) 2004-03-26 2005-10-20 Geron Corporation New protocols for making hepatocytes from embryonic stem cells
JP4491014B2 (ja) 2004-04-01 2010-06-30 ウイスコンシン アラムニ リサーチ ファンデーション 幹細胞の内胚葉および膵臓系統への分化
SG152273A1 (en) 2004-04-27 2009-05-29 Cythera Inc Pdx1 expressing endoderm
CN100457900C (zh) * 2004-06-29 2009-02-04 天津大学 细胞和组织移植用金属微囊
NZ582597A (en) 2004-07-09 2011-08-26 Viacyte Inc Preprimitive streak and mesendoderm cells
JP5687816B2 (ja) 2004-07-09 2015-03-25 ヴィアサイト,インコーポレイテッド 胚体内胚葉を分化させるための因子を同定する方法
WO2006020919A2 (en) 2004-08-13 2006-02-23 University Of Georgia Research Foundation, Inc. Compositions and methods for self-renewal and differentiation in human embryonic stem cells
US20060063141A1 (en) * 2004-09-17 2006-03-23 Mcgann Locksley E Method of cryopreserving cells
GB2434156B (en) 2004-09-29 2010-06-30 Cellartis Ab Methods for the generation of hepatocyte-like cells from human blastocyst-derived stem (hBs)
AU2006208944A1 (en) * 2005-01-28 2006-08-03 Imperial College Innovations Limited Methods for embryonic stem cell culture
EP1859026A2 (en) 2005-01-31 2007-11-28 ES Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
US20060182722A1 (en) * 2005-02-11 2006-08-17 Hering Bernhard J Methods and materials for isolating isogenic islet cells
CN100425694C (zh) 2005-04-15 2008-10-15 北京大学 诱导胚胎干细胞向胰腺细胞分化的方法
WO2007002210A2 (en) 2005-06-20 2007-01-04 Bresagen, Inc. Embryonic stem cell culture compositions and methods of use thereof
ES2743202T3 (es) 2005-10-27 2020-02-18 Viacyte Inc Endodermo de intestino proximal dorsal y ventral que expresa PDX1
GB0522564D0 (en) * 2005-11-04 2005-12-14 Reneuron Ltd Cells
GB0602063D0 (en) 2006-02-02 2006-03-15 Univ Manchester Cell Culture
EP1989289B1 (en) 2006-02-07 2017-01-04 Spinalcyte, LLC Methods and compositions for repair of cartilage using an in vivo bioreactor
CN105802904B (zh) 2006-02-23 2021-04-20 维亚赛特公司 用于培养可分化细胞的组合物和方法
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
NZ571427A (en) 2006-03-02 2012-07-27 Viacyte Inc Endocrine precursor cells, pancreatic hormone-expressing cells and methods of production
AU2007257594B2 (en) * 2006-03-07 2012-11-01 Geeta Shroff Compositions comprising human embryonic stem cells and their derivatives, methods of use, and methods of preparation
US20070237749A1 (en) * 2006-04-07 2007-10-11 Wang Taylor G Multi-membrane immunoisolation system for cellular transplant
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
WO2008013664A2 (en) * 2006-07-26 2008-01-31 Cythera, Inc. Methods of producing pancreatic hormones
US20090274712A1 (en) * 2006-10-24 2009-11-05 Dennis James E Compositions for coating cell membranes and methods of use thereof
US20080241250A1 (en) 2006-11-08 2008-10-02 Emans Pieter J In vivo bioreactors and methods of making and using same
US20080176318A1 (en) * 2006-12-07 2008-07-24 Wilson John R Highly efficient devices and methods for culturing cells
US20080279833A1 (en) 2007-05-10 2008-11-13 Matheny Robert G Laminate sheet articles for tissue regeneration
US7695963B2 (en) 2007-09-24 2010-04-13 Cythera, Inc. Methods for increasing definitive endoderm production
US8623650B2 (en) 2007-10-19 2014-01-07 Viacyte, Inc. Methods and compositions for feeder-free pluripotent stem cell media containing human serum
US20100292543A1 (en) 2007-10-30 2010-11-18 Tufts University Analysis of Endogenous Fluorescence Images to Extract Morphological/Organization Information About Living Samples
US8338170B2 (en) 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
CN102282254B (zh) * 2008-11-14 2015-12-16 维赛特公司 源于人多能干细胞的胰腺细胞的包封
SG10202001012VA (en) 2009-08-28 2020-04-29 Sernova Corp Device for cellular transplantation and uses thereof
WO2011079017A2 (en) 2009-12-23 2011-06-30 Centocor Ortho Biotech Inc. Differentiation of human embryonic stem cells
KR101903562B1 (ko) 2010-05-12 2018-10-02 얀센 바이오테크 인코포레이티드 인간 배아 줄기 세포의 분화
US10702008B2 (en) 2018-02-26 2020-07-07 Hbn Shoe, Llc Device and method of constructing shoes
US11586805B2 (en) 2021-07-26 2023-02-21 Atlassian Pty Ltd. Machine-learning-based natural language processing techniques for low-latency document summarization

Also Published As

Publication number Publication date
AU2009313870A1 (en) 2011-06-30
US20230256137A1 (en) 2023-08-17
US8278106B2 (en) 2012-10-02
US11660377B2 (en) 2023-05-30
WO2010057039A3 (en) 2010-12-02
CN105349517B (zh) 2021-05-04
EP2356227B1 (en) 2018-03-28
AU2009313870A2 (en) 2011-06-30
CN102282254B (zh) 2015-12-16
US9913930B2 (en) 2018-03-13
US20100124564A1 (en) 2010-05-20
US20190201582A1 (en) 2019-07-04
CN105349517A (zh) 2016-02-24
US9764062B2 (en) 2017-09-19
EP3363444A1 (en) 2018-08-22
EP2356227A4 (en) 2013-08-21
CA2743641A1 (en) 2010-05-20
US20130261568A1 (en) 2013-10-03
JP2021004258A (ja) 2021-01-14
CA2743641C (en) 2024-03-26
ES2667493T3 (es) 2018-05-11
JP2014159477A (ja) 2014-09-04
JP2022125204A (ja) 2022-08-26
CN102282254A (zh) 2011-12-14
AU2009313870B2 (en) 2013-07-11
EP4176888A1 (en) 2023-05-10
ES2932850T3 (es) 2023-01-27
US20130209425A1 (en) 2013-08-15
US10272179B2 (en) 2019-04-30
CA3229301A1 (en) 2010-05-20
US8425928B2 (en) 2013-04-23
US20110280915A1 (en) 2011-11-17
WO2010057039A2 (en) 2010-05-20
US20170354760A1 (en) 2017-12-14
EP3363444B1 (en) 2022-09-14
EP2356227A2 (en) 2011-08-17
JP2017197578A (ja) 2017-11-02
US20160038640A1 (en) 2016-02-11
US20160067380A1 (en) 2016-03-10
JP2018188484A (ja) 2018-11-29
US9132226B2 (en) 2015-09-15
JP2012508584A (ja) 2012-04-12

Similar Documents

Publication Publication Date Title
EP2356227A4 (en) ENCAPSULATION OF PANCREATIC CELLS DERIVED FROM HUMAN PLURIPOTENT STEM CELLS
HK1216905A1 (zh) 多能幹細胞的分化
IL251763A0 (en) Extrahepatic myrtle stem cells with great activity and methods for their separation
GB201202848D0 (en) Differemtiaiotn of human embryonic stem cells
ZA201008392B (en) Treatment of pluripotent cells
SG10201500674YA (en) Pluripotent stem cells
SG10201402428WA (en) Method of efficiently establishing induced pluripotent stem cells
GB2458863B (en) Improved culture of stem cells
GB0814249D0 (en) Uses of mesenchymal stem cells
SG10201608797WA (en) Method of efficiently establishing induced pluripotent stem cells
EP2315829A4 (en) INDUCED PLURIPOTENT STEM CELLS
ZA201001158B (en) Diferentiation of human embryonic stem cells
IL213260A (en) METHOD FOR PRODUCING FINAL ENDODERMIC CELLS FROM FLORIPONETIC STEM CELLS
HK1154404A1 (en) Methods for purifying pancreatic endoderm cells derived from human embryonic stem cells
GB2484873B (en) Differentiation of pancreatic endoderm cells.
EP2414510A4 (en) INDUCED PLURIPOTENT STEM CELLS
ZA201202685B (en) Methods of preparing mesenchymal stem cells,compositions and kit thereof
EP2438159A4 (en) METHOD FOR SELECTING A CLONE OF INDUCED PLURIPOTENT STEM CELLS
EP2536828A4 (en) METHOD FOR EFFICIENTLY ESTABLISHING INDUCED PLURIPOTENT STEM CELLS
IL211764A0 (en) Markers of induced pluripotent stem cells
EP2499241A4 (en) PROCESS FOR PRODUCING NEURAL STEM CELLS
BRPI0913925A2 (pt) Diferenciação de células-tronco pluripotentes
IL217063A0 (en) Generation of induced pluripotent stem cells from cord blood
IL221586B (en) Smooth muscle-like cells (smlcs) derived from human pluripotent stem cells
PL2456863T3 (pl) Pluripotencjalne komórki macierzyste otrzymywane z miazgi zęba