BR112018001232A2 - pd-l1 que expressa células-tronco hematopoéticas e usos - Google Patents

pd-l1 que expressa células-tronco hematopoéticas e usos

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Publication number
BR112018001232A2
BR112018001232A2 BR112018001232-7A BR112018001232A BR112018001232A2 BR 112018001232 A2 BR112018001232 A2 BR 112018001232A2 BR 112018001232 A BR112018001232 A BR 112018001232A BR 112018001232 A2 BR112018001232 A2 BR 112018001232A2
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Brazil
Prior art keywords
cths
stem cells
hematopoietic stem
pge2
expressing hematopoietic
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Application number
BR112018001232-7A
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English (en)
Inventor
Fiorina Paolo
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The Children's Medical Center Corporation
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Publication of BR112018001232A2 publication Critical patent/BR112018001232A2/pt

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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
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    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract

as modalidades descritas aqui fornecem células-tronco hematopoiéticas (cths) modificadas por engenharia, cths estimuladas artificialmente com prostaglandina e2 (pge2), composições que compreendem estas cths, métodos de utilização destas cths modificadas para tratar doenças e distúrbios autoimunes e para suprimir o sistema imunológico. em particular, as cths modificadas por engenharia ou as cths estimuladas com pge2 expressam o marcador de superfície, ligando 1 da morte celular programada 1 (pd-l1).
BR112018001232-7A 2015-07-21 2016-07-20 pd-l1 que expressa células-tronco hematopoéticas e usos BR112018001232A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562194969P 2015-07-21 2015-07-21
US62/194,969 2015-07-21
PCT/US2016/043053 WO2017015320A1 (en) 2015-07-21 2016-07-20 Pd-l1 expressing hematopoietic stem cells and uses

Publications (1)

Publication Number Publication Date
BR112018001232A2 true BR112018001232A2 (pt) 2018-09-25

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BR112018001232-7A BR112018001232A2 (pt) 2015-07-21 2016-07-20 pd-l1 que expressa células-tronco hematopoéticas e usos

Country Status (14)

Country Link
US (5) US20180214487A1 (pt)
EP (1) EP3324982A4 (pt)
JP (1) JP2018520688A (pt)
KR (1) KR20180033537A (pt)
CN (1) CN108135935A (pt)
AU (1) AU2016296741A1 (pt)
BR (1) BR112018001232A2 (pt)
CA (1) CA2993201A1 (pt)
HK (1) HK1249029A1 (pt)
IL (1) IL257046A (pt)
MX (1) MX2018000897A (pt)
RU (1) RU2018106515A (pt)
WO (1) WO2017015320A1 (pt)
ZA (1) ZA201800798B (pt)

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EP3324982A1 (en) 2018-05-30
US11642378B2 (en) 2023-05-09
JP2018520688A (ja) 2018-08-02
CN108135935A (zh) 2018-06-08
RU2018106515A3 (pt) 2019-12-09
US10751373B2 (en) 2020-08-25
KR20180033537A (ko) 2018-04-03
RU2018106515A (ru) 2019-08-21
AU2016296741A1 (en) 2018-02-22
IL257046A (en) 2018-03-29
US20180214487A1 (en) 2018-08-02
HK1249029A1 (zh) 2018-10-26
US20200129559A1 (en) 2020-04-30
US20190099450A1 (en) 2019-04-04
US10517899B2 (en) 2019-12-31
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US20230321150A1 (en) 2023-10-12
US20200085878A1 (en) 2020-03-19

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