BRPI0414961A - processo de indução da diferenciação de células tronco em células do miocárdio - Google Patents

processo de indução da diferenciação de células tronco em células do miocárdio

Info

Publication number
BRPI0414961A
BRPI0414961A BRPI0414961-0A BRPI0414961A BRPI0414961A BR PI0414961 A BRPI0414961 A BR PI0414961A BR PI0414961 A BRPI0414961 A BR PI0414961A BR PI0414961 A BRPI0414961 A BR PI0414961A
Authority
BR
Brazil
Prior art keywords
stem cell
cell differentiation
myocardial cells
differentiation induction
induction process
Prior art date
Application number
BRPI0414961-0A
Other languages
English (en)
Inventor
Keiichi Fukuda
Shinsuke Yuasa
Hideyuki Okano
Takuya Shimazaki
Uichi Koshimizu
Tomofumi Tanaka
Keijiro Sugimura
Original Assignee
Keiichi Fukuda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Keiichi Fukuda filed Critical Keiichi Fukuda
Publication of BRPI0414961A publication Critical patent/BRPI0414961A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0657—Cardiomyocytes; Heart cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/03—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from non-embryonic pluripotent stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

"PROCESSO DE INDUçãO DA DIFERENCIAçãO DE CéLULAS TRONCO EM CéLULAS DO MIOCáRDIO". Para um processo de indução da diferenciação de cardiomiócitos partindo de células tronco, é fornecido um processo para induzir eficientemente e seletivamente a diferenciação de cardiomiócitos através de um processo tal em que as células tronco são cultivadas para induzir a diferenciação em cardiomiócitos na presença de uma substância que inibe a sinalização de BMP.
BRPI0414961-0A 2003-10-03 2004-10-04 processo de indução da diferenciação de células tronco em células do miocárdio BRPI0414961A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2003346248 2003-10-03
JP2004212255 2004-07-20
PCT/JP2004/014598 WO2005033298A1 (ja) 2003-10-03 2004-10-04 幹細胞から心筋細胞を分化誘導する方法

Publications (1)

Publication Number Publication Date
BRPI0414961A true BRPI0414961A (pt) 2006-11-07

Family

ID=34425354

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0414961-0A BRPI0414961A (pt) 2003-10-03 2004-10-04 processo de indução da diferenciação de células tronco em células do miocárdio

Country Status (11)

Country Link
US (1) US7727762B2 (pt)
EP (1) EP1674562A4 (pt)
JP (1) JP4684108B2 (pt)
KR (1) KR101164104B1 (pt)
CN (2) CN103602633A (pt)
AU (1) AU2004278634B2 (pt)
BR (1) BRPI0414961A (pt)
CA (1) CA2540135C (pt)
IL (1) IL174606A (pt)
RU (1) RU2392315C2 (pt)
WO (1) WO2005033298A1 (pt)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
IL160507A0 (en) * 2001-08-24 2004-07-25 Advanced Cell Tech Inc Screening assays for identifying differentiation-inducing agents and production of differentiated cells for cell therapy
JP5560391B2 (ja) 2005-06-22 2014-07-23 アステリアス バイオセラピューティクス インコーポレイテッド ヒト胚性幹細胞の懸濁培養法
EP1739179A1 (en) * 2005-06-30 2007-01-03 Octapharma AG Serum-free stable transfection and production of recombinant human proteins in human cell lines
RU2433174C2 (ru) * 2006-04-28 2011-11-10 Дайити Санкио Компани, Лимитед Способ индукции дифференциации плюрипотентных стволовых клеток в кардиомиоциты
EP2155860B1 (en) 2007-05-03 2014-08-27 The Brigham and Women's Hospital, Inc. Multipotent stem cells and uses thereof
US8574567B2 (en) 2007-05-03 2013-11-05 The Brigham And Women's Hospital, Inc. Multipotent stem cells and uses thereof
EP2154242B1 (en) * 2007-06-07 2016-01-06 Keiichi Fukuda Method of inducing differentiation into myocardial cells using g-csf
US8799249B2 (en) * 2007-06-08 2014-08-05 Yahoo! Inc. Method and system for rendering a collection of media items
AU2008283255B2 (en) * 2007-07-31 2013-07-04 Daiichi Sankyo Company, Limited Method of constructing masses of myocardial cells and use of the myocardial cell mass
KR100937457B1 (ko) * 2007-08-10 2010-01-19 한국생명공학연구원 인간배아줄기세포와 인간배아종양세포를 심근세포 직계열로분화시키는 방법
US9962409B2 (en) 2007-10-01 2018-05-08 Vestion, Inc. Therapy using cardiac stem cells and mesenchymal stem cells
JP5453612B2 (ja) * 2007-12-06 2014-03-26 公益財団法人ヒューマンサイエンス振興財団 心筋細胞分化誘導促進剤及びその使用方法
SG10201607710UA (en) 2008-03-17 2016-11-29 Scripps Research Inst Combined chemical and genetic approaches for generation of induced pluripotent stem cells
EP3029061B1 (en) * 2008-06-18 2017-09-13 The Texas A&M University System Mesenchymal stem cells, compositions, and methods for treatment of cardiac tissue damage
CA2747398C (en) 2008-12-17 2023-06-20 The Scripps Research Institute Generation and maintenance of stem cells
JP5921430B2 (ja) * 2009-05-20 2016-05-24 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ Ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ 哺乳類細胞の心臓発生能を決定する方法
RU2662675C1 (ru) * 2009-07-09 2018-07-26 Янссен Байотек, Инк. Клетки, производные от кардиальной ткани
WO2011047300A1 (en) 2009-10-16 2011-04-21 The Scripps Research Institute Induction of pluripotent cells
EP3255142A1 (en) * 2009-10-19 2017-12-13 Cellular Dynamics International, Inc. Cardiomyocyte production
KR101168053B1 (ko) * 2009-11-06 2012-07-24 연세대학교 산학협력단 효율적이고 보편적인 전분화능 줄기세포의 신경세포 분화 유도방법
WO2011071118A1 (ja) * 2009-12-09 2011-06-16 国立大学法人京都大学 ニトロビンを含む多能性幹細胞の心筋細胞への分化促進剤
EP3936608A1 (en) 2010-03-31 2022-01-12 The Scripps Research Institute Reprogramming cells
EP2580317B1 (en) 2010-06-13 2020-12-23 Institute of Biophysics Chinese Academy of Sciences Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof
WO2011159726A2 (en) 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate
EP2610249B1 (en) * 2010-08-26 2017-10-11 Kyoto University Pluripotent stem cell cardiomyocyte differentiation-promoting agent
US9499790B2 (en) 2010-08-26 2016-11-22 Kyoto University Method for promoting differentiation of pluripotent stem cells into cardiac muscle cells
US9528090B2 (en) * 2010-08-31 2016-12-27 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
US9181529B2 (en) 2010-10-19 2015-11-10 Cellular Dynamics International, Inc. Titration of differentiation medium components
KR20140063501A (ko) 2010-12-22 2014-05-27 페이트 세러퓨틱스, 인코포레이티드 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
JP5840855B2 (ja) 2011-03-30 2016-01-06 学校法人東京女子医科大学 胚性幹細胞から心筋シートを製造する方法
US9487752B2 (en) 2011-03-30 2016-11-08 Cellular Dynamics International, Inc. Priming of pluripotent stem cells for neural differentiation
KR101996343B1 (ko) 2012-01-27 2019-07-05 고쿠리츠 다이가쿠 호진 교토 다이가쿠 전능성 줄기세포의 심근분화 유도방법
JP5920741B2 (ja) 2012-03-15 2016-05-18 ｉＨｅａｒｔ Ｊａｐａｎ株式会社 人工多能性幹細胞から心筋および血管系混合細胞群を製造する方法
CN104508121B (zh) * 2012-07-23 2018-01-19 中国科学院生物物理研究所 体外诱导多能干细胞分化为心室肌细胞的方法
US9746457B2 (en) 2012-11-30 2017-08-29 Vestion, Inc. Cardiac stem cells and methods of identifying and using the same
WO2014136519A1 (ja) 2013-03-08 2014-09-12 国立大学法人京都大学 Ｅｇｆ受容体阻害剤を含む多能性幹細胞の心筋分化促進剤
US9493742B2 (en) 2013-03-15 2016-11-15 Emory University Purification of cell mixtures using molecular beacons targeting cell specific RNA
JP5862915B2 (ja) 2013-05-31 2016-02-16 ｉＨｅａｒｔ Ｊａｐａｎ株式会社 ハイドロゲルを組み込んだ積層化細胞シート
WO2015066197A2 (en) * 2013-10-29 2015-05-07 Vestion, Inc. Cardiac neural crest cells and methods of use thereof
EP3604499A1 (en) 2014-03-04 2020-02-05 Fate Therapeutics, Inc. Improved reprogramming methods and cell culture platforms
WO2015169762A1 (en) * 2014-05-06 2015-11-12 F. Hoffmann-La Roche Ag Method for differentiation of pluripotent stem cells into cardiomyocytes
JP6651218B2 (ja) 2014-05-30 2020-02-19 国立大学法人京都大学 低分子化合物を用いた多能性幹細胞の心筋分化誘導法
KR20160142587A (ko) * 2015-06-03 2016-12-13 서울대학교산학협력단 전기·기계적 자극을 가하여 줄기세포를 심근세포로 분화시키는 방법
JP7263005B2 (ja) 2015-10-16 2023-04-24 フェイト セラピューティクス，インコーポレイテッド 基底状態の多能性の誘導及び維持に関するプラットフォーム
AU2017346898B2 (en) * 2016-10-17 2021-04-01 Keio University Undifferentiated stem cell-removing agent, and method for removing undifferentiated stem cells
JP2018093823A (ja) 2016-12-15 2018-06-21 Ｈｅａｒｔｓｅｅｄ株式会社 未分化幹細胞除去剤及び未分化幹細胞除去方法
JP6909454B2 (ja) * 2017-01-26 2021-07-28 日本メナード化粧品株式会社 幹細胞の品質を評価する方法及び幹細胞の品質評価用キット
JP6978045B2 (ja) * 2017-10-03 2021-12-08 Ｈｅａｒｔｓｅｅｄ株式会社 未分化幹細胞を培養し心筋細胞を分化誘導するシステム及び心筋細胞の製造方法
ES2966207T3 (es) 2018-03-30 2024-04-18 Orizuru Therapeutics Inc Compuesto heterocíclico
WO2019189545A1 (ja) 2018-03-30 2019-10-03 国立大学法人京都大学 細胞の製造方法
EP3778869A4 (en) 2018-03-30 2021-12-08 Kyoto University CARDIOMYOCYTE MATURATION PROMOTER
US20220145329A1 (en) 2018-08-10 2022-05-12 Kyoto University Method for transfection into cardiomyocytes using cationic lipid
CN110907644B (zh) * 2019-12-11 2023-01-06 深圳市达科为生物工程有限公司 多种细胞鉴定试剂盒及操作方法
GB202308408D0 (en) 2023-06-06 2023-07-19 Cambridge Entpr Ltd Stem cells based three-dimensional embryo model
CN117398427B (zh) * 2023-12-14 2024-02-27 再少年(北京)生物科技有限公司 包含iPS诱导定向分化成心肌细胞的药物组合在用于治疗心力衰竭中的应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1397646A (zh) * 2001-07-13 2003-02-19 上海杰隆生物工程股份有限公司 一种克隆心肌细胞、心脏组织及心脏的方法
CA2468292A1 (en) * 2001-11-26 2003-06-05 Advanced Cell Technology, Inc. Methods for making and using reprogrammed human somatic cell nuclei and autologous and isogenic human stem cells
CN1164741C (zh) * 2002-12-30 2004-09-01 浙江大学 淫羊藿苷在诱导胚胎干细胞体外定向分化方面的用途

Also Published As

Publication number Publication date
KR101164104B1 (ko) 2012-07-12
RU2392315C2 (ru) 2010-06-20
EP1674562A4 (en) 2007-04-11
KR20060080934A (ko) 2006-07-11
CN1863904A (zh) 2006-11-15
CA2540135C (en) 2012-12-04
IL174606A (en) 2011-07-31
CN103602633A (zh) 2014-02-26
US20070134215A1 (en) 2007-06-14
JPWO2005033298A1 (ja) 2006-12-14
AU2004278634A1 (en) 2005-04-14
AU2004278634B2 (en) 2009-10-01
IL174606A0 (en) 2006-08-20
WO2005033298A1 (ja) 2005-04-14
EP1674562A1 (en) 2006-06-28
RU2006114832A (ru) 2007-11-10
US7727762B2 (en) 2010-06-01
JP4684108B2 (ja) 2011-05-18
CN1863904B (zh) 2014-05-28
CA2540135A1 (en) 2005-04-14

Similar Documents

Publication Publication Date Title
BRPI0414961A (pt) processo de indução da diferenciação de células tronco em células do miocárdio
AR123811A2 (es) Composiciones de células madre mesenquimáticas purificadas y métodos relacionados
BRPI0710949A2 (pt) Método para indução de diferenciação de células tronco pluripotentes em cardiomiócitos
BR112015027996A2 (pt) organoides compreendendo células renais isoladas e suas utilizações
GB2449772A (en) Large scale production of stem cells
BR112014030417A2 (pt) composição detergente
CL2008001620A1 (es) Induccion de fenotipo tolerogenico en celulas dendriticas maduras
SG10201808863UA (en) Combined chemical and genetic approaches for generation of induced pluripotent stem cells
BRPI0810003A2 (pt) "produção de proteínas de alta manose em cultura de plantas"
SG163588A1 (en) Methods for identifying agents and conditions that modulate neurogenesis
BR0112633A (pt) Método para substituir, translocar e empilhar dna em genomas eucarióticos
TW200723003A (en) Method and system for multiple GPU support
IL199496A0 (en) In vitro methods for the induction and maintenance of plant cell lines as single suspension cells with intact cell walls, and transformation thereof
MX2020013384A (es) Compuestos de comarina sustituidos con amina exocíclica y sus usos como etiquetas fluorescentes.
BR0109415A (pt) Implantação de instalações de uma usina de eletrólise para a produção de alumìnio
BR112014032567A2 (pt) purificação de iduronato-2-sulfatase
AR081354A1 (es) Metodos y reactivos par una transferencia genica eficaz y dirigida a monocitos y macrofagos
AR056090A1 (es) Metodo y aparato para compartir memoria en un sistema de varios procesadores
BR9916842A (pt) Transformação de plastìdeo de brassica
BRPI1003783A2 (pt) Meio de cultura de células de mamíferos que compreende sobrenadante de estágios de fracionamento de cohn, seu processo de preparação e uso
WO2011153236A8 (en) Purified compositions of cardiovascular progenitor cells
BR9813099A (pt) Seleção positiva-negativa na recombinação homóloga
BR0212246A (pt) Composição indutora da resistência a doença de planta, método para controlar uma doença de planta, e, processo para a produção de uma composição
BR0212757A (pt) Composição, método para produzir uma composição de fator de crescimento, e, método para tratar um defeito de osso, tendão ou cartilagem
GB2429718A (en) Improved cardiomyocyte differentiation

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B15K Others concerning applications: alteration of classification

Ipc: C12N 5/077 (2010.01)

B11T Dismissal of application maintained [chapter 11.20 patent gazette]