BR9813099A - Seleção positiva-negativa na recombinação homóloga - Google Patents

Seleção positiva-negativa na recombinação homóloga

Info

Publication number
BR9813099A
BR9813099A BR9813099-4A BR9813099A BR9813099A BR 9813099 A BR9813099 A BR 9813099A BR 9813099 A BR9813099 A BR 9813099A BR 9813099 A BR9813099 A BR 9813099A
Authority
BR
Brazil
Prior art keywords
homologous recombination
positive
negative selection
recombination
genome
Prior art date
Application number
BR9813099-4A
Other languages
English (en)
Other versions
BR9813099B1 (pt
Inventor
Johannes Auer
Raimund Sprenger
Konrad Honold
Original Assignee
Roche Diagnostics Gmgh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8227499&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9813099(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Roche Diagnostics Gmgh filed Critical Roche Diagnostics Gmgh
Publication of BR9813099A publication Critical patent/BR9813099A/pt
Publication of BR9813099B1 publication Critical patent/BR9813099B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
    • C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Patente de Invenção: <B>"SELEçãO POSITIVA-NEGATIVA NA RECOMBINAçãO HOMóLOGA''<D>. A invenção refere-se a um processo para a introdução de um DNA estranho no genoma de uma célula visada mediante recombinação homóloga, bem como para a recombinação homóloga de construções de DNA adequadas.
BRPI9813099-4A 1997-10-20 1998-10-20 processo para a introduÇço de dna exàgeno em uma cÉlula hospedeira mediante recombinaÇço homàloga, vetor recombinante, bem como emprego do referido vetor e de receptores superficiais em posiÇço de membrana. BR9813099B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP97118175.5 1997-10-20
EP97118175 1997-10-20
PCT/EP1998/006616 WO1999020780A1 (de) 1997-10-20 1998-10-20 Positiv-negativ-selektion bei der homologen rekombination

Publications (2)

Publication Number Publication Date
BR9813099A true BR9813099A (pt) 2000-08-22
BR9813099B1 BR9813099B1 (pt) 2010-02-09

Family

ID=8227499

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9813099-4A BR9813099B1 (pt) 1997-10-20 1998-10-20 processo para a introduÇço de dna exàgeno em uma cÉlula hospedeira mediante recombinaÇço homàloga, vetor recombinante, bem como emprego do referido vetor e de receptores superficiais em posiÇço de membrana.

Country Status (17)

Country Link
US (1) US6284541B1 (pt)
EP (1) EP1025253B2 (pt)
JP (1) JP4417549B2 (pt)
KR (1) KR100566702B1 (pt)
CN (1) CN1146666C (pt)
AR (1) AR017368A1 (pt)
AT (1) ATE260982T1 (pt)
AU (1) AU730466B2 (pt)
BR (1) BR9813099B1 (pt)
CA (1) CA2306229C (pt)
DE (1) DE59810925D1 (pt)
DK (1) DK1025253T4 (pt)
ES (1) ES2213925T5 (pt)
PT (1) PT1025253E (pt)
TR (1) TR200001046T2 (pt)
WO (1) WO1999020780A1 (pt)
ZA (1) ZA989497B (pt)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7220221B2 (en) * 2000-05-03 2007-05-22 Nautilus, Inc. Exercise device with body extension mechanism
US6929909B2 (en) 2000-09-15 2005-08-16 Deltagen, Inc. Gene targeting vectors comprising conditional positive selection markers
WO2002055687A2 (en) * 2000-12-13 2002-07-18 Deltagen Inc Transgenic mice containing target gene disruptions
WO2003027261A2 (en) * 2001-09-27 2003-04-03 Functional Genetics, Inc. Methods and compositions for gene targeting by homologous recombination
DE50115580D1 (de) † 2001-10-01 2010-09-16 Deutsches Krebsforsch Verfahren zur Herstellung von Protein-Bibliotheken und zur Selektion von Proteinen daraus
US20030135872A1 (en) * 2001-12-04 2003-07-17 Burgess Robert M. Gene targeting methods and vectors
AU2003231244A1 (en) * 2002-05-02 2003-11-17 University Of North Carolina At Chapel Hill In vitro mutagenesis, phenotyping, and gene mapping
FR2860517B1 (fr) * 2003-10-03 2006-02-10 Evologic Sa Procedes et outils pour la modification chromosomique de bacteries
EP1859037A2 (en) 2005-03-08 2007-11-28 BASF Plant Science GmbH Expression enhancing intron sequences
JP5087625B2 (ja) 2006-09-01 2012-12-05 セラピューティック・ヒューマン・ポリクローナルズ・インコーポレーテッド 非ヒトトランスジェニック動物におけるヒトまたはヒト化免疫グロブリンの発現強化
UA100692C2 (ru) 2007-05-02 2013-01-25 Мериал Лимитед Днк-плазмиды, имеющие повышенную экспрессию и стабильность
WO2009130598A1 (en) * 2008-04-21 2009-10-29 Unitargeting Research As Genetically modified eukaryotic cells
CN102618453A (zh) * 2011-10-31 2012-08-01 四川农业大学 猪传染性胸膜肺炎放线杆菌Apx I C基因缺失突变株、构建方法、疫苗及应用
JP6037290B2 (ja) 2011-12-13 2016-12-07 公立大学法人横浜市立大学 遺伝子ターゲティングベクター及びその利用方法
DE102014116334A1 (de) * 2014-11-10 2016-05-12 Eberhard Karls Universität Tübingen Medizinische Fakultät Herstellung von rekombinanten Expressionsvektoren

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01203975A (ja) * 1988-02-09 1989-08-16 Konica Corp 流体試料中の特定成分の測定方法
DE3907679A1 (de) * 1989-03-09 1990-09-13 Max Planck Gesellschaft Verfahren zur gezielten veraenderung eines gens
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
EP0747485B1 (en) † 1989-11-06 1998-12-02 Cell Genesys, Inc. Production of proteins using homologous recombination
CA2040099A1 (en) 1990-05-01 1991-11-02 Mariano Barbacid Tyrosine kinase negative trkb
EP0559834A1 (en) * 1990-11-30 1993-09-15 Abbott Laboratories Immunoassay and monoclonal antibodies useful for detecting truncated nerve growth factor receptor
US5641670A (en) * 1991-11-05 1997-06-24 Transkaryotic Therapies, Inc. Protein production and protein delivery
PT101031B (pt) † 1991-11-05 2002-07-31 Transkaryotic Therapies Inc Processo para o fornecimento de proteinas por terapia genetica
ES2240962T3 (es) * 1993-06-04 2005-10-16 The United States Of America As Represented By The Secretary Of The Navy Metodo para estimular selectivamente la proliferacion de celulas t.
IT1261847B (it) 1993-09-01 1996-06-03 San Romanello Centro Fond Metodo per marcare cellule eucariote.
US6066322A (en) * 1995-03-03 2000-05-23 Millennium Pharmaceuticals, Inc. Methods for the treatment of immune disorders
US5633161A (en) * 1995-03-29 1997-05-27 Millennium Pharmaceuticals, Inc. Murine gene fomy030 coding for tumor progression inhibitor
US6017754A (en) * 1995-08-24 2000-01-25 Invitrogen Corporation System for isolating and identifying eukaryotic cells transfected with genes and vectors, host cells and methods thereof

Also Published As

Publication number Publication date
CN1146666C (zh) 2004-04-21
DE59810925D1 (de) 2004-04-08
TR200001046T2 (tr) 2001-07-23
JP2001523442A (ja) 2001-11-27
CA2306229C (en) 2011-03-22
EP1025253B2 (de) 2009-07-29
BR9813099B1 (pt) 2010-02-09
CA2306229A1 (en) 1999-04-29
CN1276836A (zh) 2000-12-13
AU730466B2 (en) 2001-03-08
EP1025253B1 (de) 2004-03-03
DK1025253T3 (da) 2004-07-12
DK1025253T4 (da) 2009-08-31
ZA989497B (en) 2000-04-19
US6284541B1 (en) 2001-09-04
WO1999020780A1 (de) 1999-04-29
PT1025253E (pt) 2004-07-30
AR017368A1 (es) 2001-09-05
ES2213925T5 (es) 2009-11-11
ES2213925T3 (es) 2004-09-01
ATE260982T1 (de) 2004-03-15
JP4417549B2 (ja) 2010-02-17
KR20010031277A (ko) 2001-04-16
KR100566702B1 (ko) 2006-04-03
AU1229399A (en) 1999-05-10
EP1025253A1 (en) 2000-08-09

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 09/02/2010, OBSERVADAS AS CONDICOES LEGAIS.

B21A Patent or certificate of addition expired [chapter 21.1 patent gazette]

Free format text: PATENTE EXTINTA EM 09.02.2020