IT1261847B - Metodo per marcare cellule eucariote. - Google Patents

Metodo per marcare cellule eucariote.

Info

Publication number
IT1261847B
IT1261847B ITRM930587A ITRM930587A IT1261847B IT 1261847 B IT1261847 B IT 1261847B IT RM930587 A ITRM930587 A IT RM930587A IT RM930587 A ITRM930587 A IT RM930587A IT 1261847 B IT1261847 B IT 1261847B
Authority
IT
Italy
Prior art keywords
receptor
marking
nucleic acid
cell surface
cell
Prior art date
Application number
ITRM930587A
Other languages
English (en)
Inventor
Claudio Bordignon
Fulvio Mavilio
Original Assignee
San Romanello Centro Fond
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11401929&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1261847(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by San Romanello Centro Fond filed Critical San Romanello Centro Fond
Priority to ITRM930587A priority Critical patent/IT1261847B/it
Publication of ITRM930587A0 publication Critical patent/ITRM930587A0/it
Priority to US08/602,791 priority patent/US6074836A/en
Priority to EP94926187A priority patent/EP0724634B1/en
Priority to DK94926187T priority patent/DK0724634T3/da
Priority to ES94926187T priority patent/ES2210260T3/es
Priority to CA002170757A priority patent/CA2170757C/en
Priority to PCT/EP1994/002687 priority patent/WO1995006723A1/en
Priority to PT94926187T priority patent/PT724634E/pt
Priority to DE69433342T priority patent/DE69433342T2/de
Priority to AT94926187T priority patent/ATE254660T1/de
Priority to JP7507213A priority patent/JP2781276B2/ja
Priority to IL11081594A priority patent/IL110815A0/xx
Priority to IL147557A priority patent/IL147557A/en
Publication of ITRM930587A1 publication Critical patent/ITRM930587A1/it
Publication of IT1261847B publication Critical patent/IT1261847B/it
Application granted granted Critical
Priority to IL14755702A priority patent/IL147557A0/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Food Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un metodo per marcare una cellula eucariota (mammifero) esprimendo in questa cellula un acido nucleico, detto acido nucleico codificante un recettore di superficie cellulare, e successivamente presentando detto recettore alla superficie cellulare, caratterizzato dal fatto di utilizzare un acido nucleico in cui la regione codificante il dominio intracellulare del recettore è stata completamente o parzialmente deleta o modificata in maniera tale che il recettore presentato alla superficie cellulare non può, dopo legame al suo ligando, effettuare alcuna trasduzione di segnale, è efficace e utilizzabile nella terapia genica.
ITRM930587A 1993-09-01 1993-09-01 Metodo per marcare cellule eucariote. IT1261847B (it)

Priority Applications (14)

Application Number Priority Date Filing Date Title
ITRM930587A IT1261847B (it) 1993-09-01 1993-09-01 Metodo per marcare cellule eucariote.
JP7507213A JP2781276B2 (ja) 1993-09-01 1994-08-11 マーカーとしての細胞表面レセプターの使用による真核細胞のマーキング方法
PT94926187T PT724634E (pt) 1993-09-01 1994-08-11 Metodo para a marcacao de celulas eucarioticas por meio da utilizacao de um receptor da superficie da celula como um marcador
DE69433342T DE69433342T2 (de) 1993-09-01 1994-08-11 Methode zur markierung von eukaryotischen zellen mittels verwendung von rezeptoren der zelloberfläche als marker
DK94926187T DK0724634T3 (da) 1993-09-01 1994-08-11 Fremgangsmåde til mærkning af eukaryote celler ved anvendelsen af en celleoverfladereceptor som markør
ES94926187T ES2210260T3 (es) 1993-09-01 1994-08-11 Metodo de marcado de celulas eucarioticas empleando como marcador un receptor de superficie celular.
CA002170757A CA2170757C (en) 1993-09-01 1994-08-11 Method of marking eukaryotic cells by the use of a cell surface receptor as a marker
PCT/EP1994/002687 WO1995006723A1 (en) 1993-09-01 1994-08-11 Method of marking eukaryotic cells by the use of a cell surface receptor as a marker
US08/602,791 US6074836A (en) 1993-09-01 1994-08-11 Method of marking eukaryotic cells
EP94926187A EP0724634B1 (en) 1993-09-01 1994-08-11 Method of marking eukaryotic cells by the use of a cell surface receptor as a marker
AT94926187T ATE254660T1 (de) 1993-09-01 1994-08-11 Methode zur markierung von eukaryotischen zellen mittels verwendung von rezeptoren der zelloberfläche als marker
IL147557A IL147557A (en) 1993-09-01 1994-08-29 Method for the immunoselection and immunoseparation of transfected eukaryotic cells
IL11081594A IL110815A0 (en) 1993-09-01 1994-08-29 Method of marking eukaryotic cells
IL14755702A IL147557A0 (en) 1993-09-01 2002-01-10 Method for the immunoselection and immunoseparation of transfected eukaryotic cells

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITRM930587A IT1261847B (it) 1993-09-01 1993-09-01 Metodo per marcare cellule eucariote.

Publications (3)

Publication Number Publication Date
ITRM930587A0 ITRM930587A0 (it) 1993-09-01
ITRM930587A1 ITRM930587A1 (it) 1995-03-01
IT1261847B true IT1261847B (it) 1996-06-03

Family

ID=11401929

Family Applications (1)

Application Number Title Priority Date Filing Date
ITRM930587A IT1261847B (it) 1993-09-01 1993-09-01 Metodo per marcare cellule eucariote.

Country Status (12)

Country Link
US (1) US6074836A (it)
EP (1) EP0724634B1 (it)
JP (1) JP2781276B2 (it)
AT (1) ATE254660T1 (it)
CA (1) CA2170757C (it)
DE (1) DE69433342T2 (it)
DK (1) DK0724634T3 (it)
ES (1) ES2210260T3 (it)
IL (2) IL110815A0 (it)
IT (1) IT1261847B (it)
PT (1) PT724634E (it)
WO (1) WO1995006723A1 (it)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19643682C1 (de) * 1996-10-23 1998-01-15 Manfred Prof Dr Gareis Verfahren zum Herkunftsnachweis von Nutztieren sowie davon stammenden Produkten
US6500421B1 (en) * 1996-11-04 2002-12-31 St. Jude Children's Research Hospital In vivo selection of primitive hematopoietic cells
JP4080544B2 (ja) 1997-01-31 2008-04-23 株式会社ディナベック研究所 ノックアウト動物
EP0904786B1 (en) * 1997-08-22 2004-12-15 Science Park Raf S.p.A. Tumor vaccination by use of autologous or HLA-related antigen presenting cell (APC) transduced with a tumour antigen and a foreign antigen capable of causing an immune reaction
ZA989497B (en) 1997-10-20 2000-04-19 Roche Diagnostics Gmbh Positive-negative selection in homologous recombination.
IT1297016B1 (it) * 1997-12-23 1999-08-03 San Raffaele Centro Fond Processo di selezione di linfociti t cd4+ per la transduzione di geni anti-hiv
IT1312570B1 (it) * 1999-05-28 2002-04-22 Genera Spa Metodo per il traferimento di antigeni a cellule dendritiche.
US6790614B1 (en) 1999-11-19 2004-09-14 Novartis Ag Selectable cell surface marker genes
WO2001036659A2 (en) * 1999-11-19 2001-05-25 Novartis Ag Selectable cell surface marker genes
JP2003533183A (ja) * 2000-03-30 2003-11-11 ノバルティス アクチエンゲゼルシャフト 選択マーカー遺伝子
DE10019075B4 (de) * 2000-04-18 2007-01-18 Vision 7 Gmbh Verwendung von CD34 oder einem davon abgeleiteten Polypeptid als Zell-Oberflächen- bzw. Gentransfer-Marker
EP1390384A4 (en) * 2001-05-30 2005-08-17 Chromos Molecular Systems Inc PLATFORMS ON CHROMOSOME BASIS
US7737124B2 (en) * 2001-09-13 2010-06-15 California Institute Of Technology Method for expression of small antiviral RNA molecules with reduced cytotoxicity within a cell
US7919309B2 (en) 2001-09-13 2011-04-05 California Institute Of Technology Method for expression of small antiviral RNA molecules within a cell
AU2003241409A1 (en) * 2003-05-12 2005-01-21 Potomac Pharmaceuticals, Inc. Gene expression suppression agents
GB0413702D0 (en) 2004-06-18 2004-07-21 Molmed Spa Thymidine kinase
JP4956427B2 (ja) * 2004-07-21 2012-06-20 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド レンチウイルスベクターおよびその使用
AU2012320480A1 (en) 2011-10-05 2014-04-24 Molmed Spa Viral vectors purification system
US20140037599A1 (en) * 2012-08-03 2014-02-06 The Trustees Of The University Of Pennsylvania Compositions and Methods of Treating T Cell Deficiency

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5055459A (en) * 1986-06-30 1991-10-08 Board Of Regents, The University Of Texas Selective elimination of malignant cells from bone marrow by bis (acyloxy) propylphosphoramidates
AU7583891A (en) * 1990-04-17 1991-11-11 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Selective cytotoxic reagents comprising toxic moieties derived from mammalian proteins
CA2040099A1 (en) * 1990-05-01 1991-11-02 Mariano Barbacid Tyrosine kinase negative trkb
US5462856A (en) * 1990-07-19 1995-10-31 Bunsen Rush Laboratories, Inc. Methods for identifying chemicals that act as agonists or antagonists for receptors and other proteins involved in signal transduction via pathways that utilize G-proteins
ATE129746T1 (de) * 1990-09-14 1995-11-15 Univ Johns Hopkins Verfahren und zusammensetzungen für gentherapie und stärkung des immunsystems.
US5470730A (en) * 1990-09-28 1995-11-28 Immunex Method for producing TH -independent cytotoxic T lymphocytes
JP3150340B2 (ja) * 1990-11-13 2001-03-26 イムネクス コーポレイション 二機能選択可能融合遺伝子
AU9164991A (en) * 1990-11-30 1992-06-25 Abbott Laboratories Immunoassay and monoclonal antibodies useful for detecting truncated nerve growth factor receptor
AU1922092A (en) * 1991-05-03 1992-12-21 Albert Einstein College Of Medicine Of Yeshiva University Targeted delivery of genes encoding cell surface receptors
US5529774A (en) * 1991-08-13 1996-06-25 The Regents Of The University Of California In vivo transfer of the HSV-TK gene implanted retroviral producer cells
JP2006344159A (ja) * 2005-06-10 2006-12-21 Toshiba Information Systems (Japan) Corp 共通バス接続デバイス用通信制御装置

Also Published As

Publication number Publication date
EP0724634B1 (en) 2003-11-19
JPH09501569A (ja) 1997-02-18
DE69433342T2 (de) 2004-09-09
JP2781276B2 (ja) 1998-07-30
EP0724634A1 (en) 1996-08-07
CA2170757A1 (en) 1995-03-09
DE69433342D1 (de) 2003-12-24
PT724634E (pt) 2004-03-31
ES2210260T3 (es) 2004-07-01
WO1995006723A1 (en) 1995-03-09
IL110815A0 (en) 1994-11-11
US6074836A (en) 2000-06-13
ITRM930587A1 (it) 1995-03-01
CA2170757C (en) 2003-04-22
ITRM930587A0 (it) 1993-09-01
DK0724634T3 (da) 2004-03-29
IL147557A (en) 2006-10-31
ATE254660T1 (de) 2003-12-15

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TA Fee payment date (situation as of event date), data collected since 19931001

Effective date: 19970929