CO5721011A2 - Elementos de respuesta al estrogeno de bmp-2 y metodos de uso de los mismos - Google Patents
Elementos de respuesta al estrogeno de bmp-2 y metodos de uso de los mismosInfo
- Publication number
- CO5721011A2 CO5721011A2 CO05023614A CO05023614A CO5721011A2 CO 5721011 A2 CO5721011 A2 CO 5721011A2 CO 05023614 A CO05023614 A CO 05023614A CO 05023614 A CO05023614 A CO 05023614A CO 5721011 A2 CO5721011 A2 CO 5721011A2
- Authority
- CO
- Colombia
- Prior art keywords
- nucleic acid
- cell
- estrogen receptor
- vector
- host cell
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
1.- Una molécula de acido nucleico aislada que comprende un acido nucleico, que corresponde a una region reguladora BMP-2, caracterizada porque comprende un elemento sensible al estrogeno.2.- Un vector que comprende el acido nucleico de conformidad con la reivindicacion 1, caracterizado porque el acido nucleico se enlaza operativamente a un segundo acido nucleico.3.- Una célula hospedadora caracterizada porque comprende el vector de conformidad con la reivindicacion 2.4.- La célula hospedadora de conformidad con la reivindicacion 3, caracterizada porque la célula comprende ademas un receptor de estrogeno.5.- La célula hospedadora de conformidad con la reivindicacion 4, caracterizada porque el receptor de estrogeno es a.6.- La célula hospedadora de conformidad con la reivindicacion 4, caracterizada porque el receptor de estrogeno es ß.7.- Un método para la identificacion de un agente terapéutico para la prevencion y/o tratamiento de la osteoporosis, caracterizado porque comprende:(a) introducir en una célula el vector de conformidad con la reivindicacion 2, (b) poner en contacto la célula con un agente candidato;y (c) monitorear la expresion de la proteina codificada por el acido nucleico reportero, en donde la expresion inducida de la proteina indica que el agente candidato es un agente terapéutico potencial.8.- El método de conformidad con la reivindicacion 7, caracterizado porque en la etapa (a) un segundo vector de expresion que comprende una molécula de acido nucleico que codifica a un receptor de estrogeno se introduce en la célula.9.- El método de conformidad con la reivindicacion 8, caracterizado porque el receptor de estrogeno es a.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40402402P | 2002-08-16 | 2002-08-16 |
Publications (1)
Publication Number | Publication Date |
---|---|
CO5721011A2 true CO5721011A2 (es) | 2007-01-31 |
Family
ID=31888312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CO05023614A CO5721011A2 (es) | 2002-08-16 | 2005-03-14 | Elementos de respuesta al estrogeno de bmp-2 y metodos de uso de los mismos |
Country Status (14)
Country | Link |
---|---|
US (1) | US20050271637A1 (es) |
EP (1) | EP1534731A4 (es) |
JP (1) | JP2006500925A (es) |
KR (1) | KR20050083635A (es) |
CN (1) | CN1753904A (es) |
AU (1) | AU2003261246A1 (es) |
BR (1) | BR0313729A (es) |
CA (1) | CA2497304A1 (es) |
CO (1) | CO5721011A2 (es) |
MX (1) | MXPA05001694A (es) |
NO (1) | NO20050935L (es) |
RU (1) | RU2005107330A (es) |
WO (1) | WO2004016639A1 (es) |
ZA (1) | ZA200502131B (es) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2574777C (en) | 2004-07-23 | 2015-09-01 | Acceleron Pharma Inc. | Actrii receptor polypeptides, methods and compositions |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
EP1973559B1 (en) | 2005-11-23 | 2013-01-09 | Acceleron Pharma Inc. | Activin-actriia antagonists and uses for promoting bone growth |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
TWI480048B (zh) | 2007-02-01 | 2015-04-11 | Acceleron Pharma Inc | 活化素-ActRIIa拮抗劑及其治療或預防乳癌之用途 |
TW201627320A (zh) | 2007-02-02 | 2016-08-01 | 艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
TW201808334A (zh) | 2007-02-09 | 2018-03-16 | 艾瑟勒朗法瑪公司 | 包含ActRIIa-Fc融合蛋白的醫藥組合物;ActRIIa-Fc融合蛋白於治療或預防與癌症相關的骨質流失之用途;ActRIIa-Fc融合蛋白於治療或預防多發性骨髓瘤之用途 |
EP2207562B1 (en) | 2007-09-18 | 2017-05-31 | Acceleron Pharma, Inc. | Activin-actriia antagonists and uses for decreasing or inhibiting fsh secretion |
TW201803586A (zh) | 2008-08-14 | 2018-02-01 | 艾瑟勒朗法瑪公司 | 使用gdf阱以增加紅血球水平 |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
ES2575695T3 (es) | 2009-03-30 | 2016-06-30 | Acceleron Pharma Inc. | Antagonistas de BMP-ALK3 y sus usos para estimular el crecimiento óseo |
EP3345921A1 (en) | 2009-06-08 | 2018-07-11 | Acceleron Pharma Inc. | Use of anti-actriib antibodies for increasing thermogenic adipocytes |
ES2836534T3 (es) | 2009-06-12 | 2021-06-25 | Acceleron Pharma Inc | Proteínas de fusión de ActRIIB-Fc truncadas |
ES2658292T3 (es) | 2009-11-17 | 2018-03-09 | Acceleron Pharma, Inc. | Proteínas ActRIIB y variantes y usos de las mismas con respecto a la inducción de la utrofina para el tratamiento de la distrofia muscular |
US8501690B2 (en) | 2010-04-30 | 2013-08-06 | John G. Stark | Use of selective estrogen receptor modulator for joint fusion and other repair or healing of connective tissue |
CA2817008A1 (en) | 2010-11-08 | 2012-05-18 | Acceleron Pharma Inc. | Actriia binding agents and uses thereof |
CN104936605A (zh) | 2012-11-02 | 2015-09-23 | 细胞基因公司 | 激活素-actrii拮抗剂和用于治疗骨和其它病症的用途 |
WO2015192111A1 (en) | 2014-06-13 | 2015-12-17 | Acceleron Pharma, Inc. | Methods and compositions for treating ulcers |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
KR102556991B1 (ko) | 2014-12-03 | 2023-07-19 | 셀진 코포레이션 | 액티빈-ActRII 길항제 및 빈혈 치료를 위한 용도 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4870009A (en) * | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
JPS59500735A (ja) * | 1983-04-18 | 1984-04-26 | エス・ア−ル・アイ・インタ−ナシヨナル | 人間の癌診断のための方法および試験キツト |
US4736866B1 (en) * | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
US6083690A (en) * | 1995-06-02 | 2000-07-04 | Osteoscreen, Inc. | Methods and compositions for identifying osteogenic agents |
WO1998025460A1 (en) * | 1996-12-13 | 1998-06-18 | Zymogenetics, Inc. | Compositions and methods for stimulating bone growth |
JPH11313673A (ja) * | 1998-04-30 | 1999-11-16 | Hoechst Marion Roussel Kk | ヒトbmp−2プロモーターおよびこれを用いた骨関連物質の探索法 |
US6630304B1 (en) * | 2000-09-14 | 2003-10-07 | Decode Genetics Ehf. | Human osteoporosis gene |
-
2003
- 2003-08-18 KR KR1020057002620A patent/KR20050083635A/ko not_active Application Discontinuation
- 2003-08-18 WO PCT/US2003/023271 patent/WO2004016639A1/en not_active Application Discontinuation
- 2003-08-18 EP EP03788273A patent/EP1534731A4/en not_active Withdrawn
- 2003-08-18 MX MXPA05001694A patent/MXPA05001694A/es unknown
- 2003-08-18 RU RU2005107330/13A patent/RU2005107330A/ru not_active Application Discontinuation
- 2003-08-18 CN CNA038241234A patent/CN1753904A/zh active Pending
- 2003-08-18 CA CA002497304A patent/CA2497304A1/en not_active Abandoned
- 2003-08-18 US US10/642,503 patent/US20050271637A1/en not_active Abandoned
- 2003-08-18 AU AU2003261246A patent/AU2003261246A1/en not_active Abandoned
- 2003-08-18 JP JP2004529191A patent/JP2006500925A/ja active Pending
- 2003-08-18 BR BR0313729-5A patent/BR0313729A/pt not_active Application Discontinuation
-
2005
- 2005-02-21 NO NO20050935A patent/NO20050935L/no not_active Application Discontinuation
- 2005-03-14 CO CO05023614A patent/CO5721011A2/es not_active Application Discontinuation
- 2005-03-14 ZA ZA200502131A patent/ZA200502131B/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2006500925A (ja) | 2006-01-12 |
EP1534731A1 (en) | 2005-06-01 |
MXPA05001694A (es) | 2005-07-22 |
CA2497304A1 (en) | 2004-02-26 |
EP1534731A4 (en) | 2006-05-17 |
CN1753904A (zh) | 2006-03-29 |
NO20050935L (no) | 2005-05-10 |
KR20050083635A (ko) | 2005-08-26 |
AU2003261246A1 (en) | 2004-03-03 |
WO2004016639A1 (en) | 2004-02-26 |
ZA200502131B (en) | 2005-09-21 |
BR0313729A (pt) | 2005-06-21 |
US20050271637A1 (en) | 2005-12-08 |
RU2005107330A (ru) | 2005-10-10 |
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