NO20050935L - BMP-2 ostrogen-responsivt element og fremgangsmater for anvendelse av samme - Google Patents
BMP-2 ostrogen-responsivt element og fremgangsmater for anvendelse av sammeInfo
- Publication number
- NO20050935L NO20050935L NO20050935A NO20050935A NO20050935L NO 20050935 L NO20050935 L NO 20050935L NO 20050935 A NO20050935 A NO 20050935A NO 20050935 A NO20050935 A NO 20050935A NO 20050935 L NO20050935 L NO 20050935L
- Authority
- NO
- Norway
- Prior art keywords
- estrogen
- bmp
- same
- responsive element
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6897—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/51—Bone morphogenetic factor; Osteogenins; Osteogenic factor; Bone-inducing factor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/001—Vector systems having a special element relevant for transcription controllable enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/008—Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/80—Vector systems having a special element relevant for transcription from vertebrates
- C12N2830/85—Vector systems having a special element relevant for transcription from vertebrates mammalian
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- Rheumatology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Analytical Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
Oppfinnelsen angår en isolert nukleinsyre svarende til BMP-2regulatorregion, eller et fragment derav som omfatter et østrogenresponsivt element, en vektor omfattende det samme og celler som omfatter vektoren. Ved en annen utførelsesform tilveiebringer oppfinnelsen fremgangsmåter for identifisering av en østrogenagonist, -antagonist og et terapeutisk middel. Ved en annen utførelsesform tilveiebringer oppfinnelsen fremgangsmåter for behandling av tilstander som er forbundet med østrogeninsuffisiens eller med mangel på respons overfor eksternt østrogen eller agonister til dette.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40402402P | 2002-08-16 | 2002-08-16 | |
PCT/US2003/023271 WO2004016639A1 (en) | 2002-08-16 | 2003-08-18 | Bmp-2 estrogen responsive element and methods of using the same |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20050935L true NO20050935L (no) | 2005-05-10 |
Family
ID=31888312
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20050935A NO20050935L (no) | 2002-08-16 | 2005-02-21 | BMP-2 ostrogen-responsivt element og fremgangsmater for anvendelse av samme |
Country Status (14)
Country | Link |
---|---|
US (1) | US20050271637A1 (no) |
EP (1) | EP1534731A4 (no) |
JP (1) | JP2006500925A (no) |
KR (1) | KR20050083635A (no) |
CN (1) | CN1753904A (no) |
AU (1) | AU2003261246A1 (no) |
BR (1) | BR0313729A (no) |
CA (1) | CA2497304A1 (no) |
CO (1) | CO5721011A2 (no) |
MX (1) | MXPA05001694A (no) |
NO (1) | NO20050935L (no) |
RU (1) | RU2005107330A (no) |
WO (1) | WO2004016639A1 (no) |
ZA (1) | ZA200502131B (no) |
Families Citing this family (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3489257A1 (en) | 2004-07-23 | 2019-05-29 | Acceleron Pharma Inc. | Actrii receptor polypeptides, methods and compositions |
US8128933B2 (en) | 2005-11-23 | 2012-03-06 | Acceleron Pharma, Inc. | Method of promoting bone growth by an anti-activin B antibody |
RS58231B1 (sr) | 2005-11-23 | 2019-03-29 | Acceleron Pharma Inc | Antagonisti aktivin-actriia i primene za stimulaciju rasta kostiju |
US8895016B2 (en) | 2006-12-18 | 2014-11-25 | Acceleron Pharma, Inc. | Antagonists of activin-actriia and uses for increasing red blood cell levels |
TWI584815B (zh) | 2007-02-01 | 2017-06-01 | 艾瑟勒朗法瑪公司 | 活化素-ActRIIa拮抗劑及其治療或預防乳癌之用途 |
TW201907946A (zh) | 2007-02-02 | 2019-03-01 | 美商艾瑟勒朗法瑪公司 | 衍生自ActRIIB的變體與其用途 |
EA018221B1 (ru) | 2007-02-09 | 2013-06-28 | Акселерон Фарма Инк. | АНТАГОНИСТЫ АКТИВИНА-ActRIIa И ПРИМЕНЕНИЕ ДЛЯ СТИМУЛЯЦИИ РОСТА КОСТИ У БОЛЬНЫХ РАКОМ |
CN103877564A (zh) | 2007-09-18 | 2014-06-25 | 阿塞勒隆制药公司 | 活化素-actriia拮抗剂和减少或抑制fsh分泌的用途 |
PL3494986T3 (pl) | 2008-08-14 | 2020-11-16 | Acceleron Pharma Inc. | Pułapki GDF |
US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
JP5755635B2 (ja) | 2009-03-30 | 2015-07-29 | アクセルロン ファーマ, インコーポレイテッド | Bmp−alk3アンタゴニストおよび骨成長促進のためのその使用 |
AU2010258931B2 (en) | 2009-06-08 | 2015-04-23 | Acceleron Pharma Inc. | Methods for increasing thermogenic adipocytes |
WO2010151426A1 (en) | 2009-06-12 | 2010-12-29 | Acceleron Pharma Inc. | Truncated actriib-fc fusion proteins |
EP2501400B1 (en) | 2009-11-17 | 2017-11-01 | Acceleron Pharma, Inc. | Actriib proteins and variants and uses therefore relating to utrophin induction for muscular dystrophy therapy |
US8501690B2 (en) | 2010-04-30 | 2013-08-06 | John G. Stark | Use of selective estrogen receptor modulator for joint fusion and other repair or healing of connective tissue |
EP2638065A4 (en) | 2010-11-08 | 2014-04-09 | Acceleron Pharma Inc | ACTRIIA BINDING AGENTS AND USES THEREOF |
AU2013337677B2 (en) | 2012-11-02 | 2018-06-28 | Celgene Corporation | Activin-ActRII antagonists and uses for treating bone and other disorders |
US9850298B2 (en) | 2014-06-13 | 2017-12-26 | Acceleron Pharma Inc. | Methods for treating ulcers in thalassemia syndrome with an ActRIIB polypeptide |
MA41052A (fr) | 2014-10-09 | 2017-08-15 | Celgene Corp | Traitement d'une maladie cardiovasculaire à l'aide de pièges de ligands d'actrii |
RS64214B1 (sr) | 2014-12-03 | 2023-06-30 | Celgene Corp | Antagonisti aktivin-actrii i njihova primena u lečenju mijelodisplastičnog sindroma |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4870009A (en) * | 1982-11-22 | 1989-09-26 | The Salk Institute For Biological Studies | Method of obtaining gene product through the generation of transgenic animals |
JPS59500735A (ja) * | 1983-04-18 | 1984-04-26 | エス・ア−ル・アイ・インタ−ナシヨナル | 人間の癌診断のための方法および試験キツト |
US4736866B1 (en) * | 1984-06-22 | 1988-04-12 | Transgenic non-human mammals | |
US6083690A (en) * | 1995-06-02 | 2000-07-04 | Osteoscreen, Inc. | Methods and compositions for identifying osteogenic agents |
CA2274789A1 (en) * | 1996-12-13 | 1998-06-18 | Zymogenetics, Inc. | Compositions and methods for stimulating bone growth |
JPH11313673A (ja) * | 1998-04-30 | 1999-11-16 | Hoechst Marion Roussel Kk | ヒトbmp−2プロモーターおよびこれを用いた骨関連物質の探索法 |
US6630304B1 (en) * | 2000-09-14 | 2003-10-07 | Decode Genetics Ehf. | Human osteoporosis gene |
-
2003
- 2003-08-18 CA CA002497304A patent/CA2497304A1/en not_active Abandoned
- 2003-08-18 CN CNA038241234A patent/CN1753904A/zh active Pending
- 2003-08-18 MX MXPA05001694A patent/MXPA05001694A/es unknown
- 2003-08-18 EP EP03788273A patent/EP1534731A4/en not_active Withdrawn
- 2003-08-18 RU RU2005107330/13A patent/RU2005107330A/ru not_active Application Discontinuation
- 2003-08-18 BR BR0313729-5A patent/BR0313729A/pt not_active Application Discontinuation
- 2003-08-18 KR KR1020057002620A patent/KR20050083635A/ko not_active Application Discontinuation
- 2003-08-18 US US10/642,503 patent/US20050271637A1/en not_active Abandoned
- 2003-08-18 JP JP2004529191A patent/JP2006500925A/ja active Pending
- 2003-08-18 WO PCT/US2003/023271 patent/WO2004016639A1/en not_active Application Discontinuation
- 2003-08-18 AU AU2003261246A patent/AU2003261246A1/en not_active Abandoned
-
2005
- 2005-02-21 NO NO20050935A patent/NO20050935L/no not_active Application Discontinuation
- 2005-03-14 ZA ZA200502131A patent/ZA200502131B/en unknown
- 2005-03-14 CO CO05023614A patent/CO5721011A2/es not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
AU2003261246A1 (en) | 2004-03-03 |
EP1534731A4 (en) | 2006-05-17 |
CO5721011A2 (es) | 2007-01-31 |
CA2497304A1 (en) | 2004-02-26 |
US20050271637A1 (en) | 2005-12-08 |
MXPA05001694A (es) | 2005-07-22 |
KR20050083635A (ko) | 2005-08-26 |
EP1534731A1 (en) | 2005-06-01 |
WO2004016639A1 (en) | 2004-02-26 |
JP2006500925A (ja) | 2006-01-12 |
BR0313729A (pt) | 2005-06-21 |
ZA200502131B (en) | 2005-09-21 |
RU2005107330A (ru) | 2005-10-10 |
CN1753904A (zh) | 2006-03-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
NO20050935L (no) | BMP-2 ostrogen-responsivt element og fremgangsmater for anvendelse av samme | |
Bellare et al. | A role for ubiquitin in the spliceosome assembly pathway | |
Kwak et al. | Methylation of SPT5 regulates its interaction with RNA polymerase II and transcriptional elongation properties | |
Giangrande et al. | The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene. | |
Ohsato et al. | Mammalian mitochondrial endonuclease G: Digestion of R‐loops and localization in intermembrane space | |
WO2005017646A3 (en) | System, software and methods for biomarker identification | |
WO2001012662A3 (en) | Membrane associated proteins | |
NO20050144L (no) | Fremgangsmate for a fremstille substituerte pyrimidiner | |
BRPI0511906A (pt) | isolamento de proteìnas do plasma ou soro | |
WO1999036550A3 (en) | Human protease molecules | |
DE60322880D1 (de) | Einfache katalytische dna-biosensoren für ionen auf grundlage von farbveränderungen | |
NO20070067L (no) | Pyrrolopyridinderivater | |
ATE488591T1 (de) | Neuer l-lysin-induzierbarer promotor | |
Chong et al. | Pivotal role for the ubiquitin Y59-E51 loop in lysine 48 polyubiquitination | |
WO2005003958A3 (en) | Methods and apparatus to provide secure firmware storage and service access | |
NO20055210L (no) | Inhibitorproteiner av en protease og anvendelse derav | |
WO2000026245A3 (en) | Human membrane transport proteins | |
WO2000005374A3 (en) | Molecules associated with cell proliferation | |
NO20024048D0 (no) | Fremgangsmåte for drift av en elektrolysecelle samt midler for samme | |
ATE342998T1 (de) | Replikation -defektive baculoviren expressionssystem | |
WO2000078954A3 (en) | Human transcriptional regulator proteins | |
WO2003077875A3 (en) | Proteins associated with growth, differentiation, and death | |
WO2001083524A3 (en) | Rna metabolism proteins | |
WO2002002757A3 (en) | Adenylyl and guanylyl cyclases | |
WO2004003162A3 (en) | Enzymes |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |