WO2001083524A3 - Rna metabolism proteins - Google Patents

Rna metabolism proteins Download PDF

Info

Publication number
WO2001083524A3
WO2001083524A3 PCT/US2001/013862 US0113862W WO0183524A3 WO 2001083524 A3 WO2001083524 A3 WO 2001083524A3 US 0113862 W US0113862 W US 0113862W WO 0183524 A3 WO0183524 A3 WO 0183524A3
Authority
WO
WIPO (PCT)
Prior art keywords
rmep
rna metabolism
metabolism proteins
provides
proteins
Prior art date
Application number
PCT/US2001/013862
Other languages
French (fr)
Other versions
WO2001083524A2 (en
Inventor
Preeti Lal
Henry Yue
Y Tom Tang
Dyung Aina M Lu
Yalda Azimzai
Janice Au-Young
Jennifer L Hillman
Mariah R Baughn
Monique G Yao
Neil Burford
Sajeev Batra
Jennifer J Policky
Original Assignee
Incyte Genomics Inc
Preeti Lal
Henry Yue
Y Tom Tang
Dyung Aina M Lu
Yalda Azimzai
Janice Au-Young
Jennifer L Hillman
Mariah R Baughn
Monique G Yao
Neil Burford
Sajeev Batra
Jennifer J Policky
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Incyte Genomics Inc, Preeti Lal, Henry Yue, Y Tom Tang, Dyung Aina M Lu, Yalda Azimzai, Janice Au-Young, Jennifer L Hillman, Mariah R Baughn, Monique G Yao, Neil Burford, Sajeev Batra, Jennifer J Policky filed Critical Incyte Genomics Inc
Priority to AU2001257427A priority Critical patent/AU2001257427A1/en
Priority to US10/258,662 priority patent/US20040082029A1/en
Priority to CA002407435A priority patent/CA2407435A1/en
Priority to EP01930939A priority patent/EP1278843A2/en
Priority to JP2001580948A priority patent/JP2004511208A/en
Publication of WO2001083524A2 publication Critical patent/WO2001083524A2/en
Publication of WO2001083524A3 publication Critical patent/WO2001083524A3/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • AIDS & HIV (AREA)
  • Obesity (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The invention provides human RNA metabolism proteins (RMEP) and polynucleotides which identify and encode RMEP. The invention also provides expression vectors, host cells, antibodies, agonists, and antagonists. The invention also provides methods for diagnosing, treating, or preventing disorders associated with aberrant expression of RMEP.
PCT/US2001/013862 2000-04-28 2001-04-27 Rna metabolism proteins WO2001083524A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU2001257427A AU2001257427A1 (en) 2000-04-28 2001-04-27 Rna metabolism proteins
US10/258,662 US20040082029A1 (en) 2001-04-27 2001-04-27 Rna metabolism proteins
CA002407435A CA2407435A1 (en) 2000-04-28 2001-04-27 Rna metabolism proteins
EP01930939A EP1278843A2 (en) 2000-04-28 2001-04-27 Rna metabolism proteins
JP2001580948A JP2004511208A (en) 2000-04-28 2001-04-27 RNA metabolism protein

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
US20018400P 2000-04-28 2000-04-28
US60/200,184 2000-04-28
US20209000P 2000-05-04 2000-05-04
US20187500P 2000-05-04 2000-05-04
US60/201,875 2000-05-04
US60/202,090 2000-05-04
US21023200P 2000-06-06 2000-06-06
US60/210,232 2000-06-06
US22055300P 2000-07-25 2000-07-25
US60/220,553 2000-07-25

Publications (2)

Publication Number Publication Date
WO2001083524A2 WO2001083524A2 (en) 2001-11-08
WO2001083524A3 true WO2001083524A3 (en) 2002-06-20

Family

ID=27539426

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2001/013862 WO2001083524A2 (en) 2000-04-28 2001-04-27 Rna metabolism proteins

Country Status (5)

Country Link
EP (1) EP1278843A2 (en)
JP (1) JP2004511208A (en)
AU (1) AU2001257427A1 (en)
CA (1) CA2407435A1 (en)
WO (1) WO2001083524A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020111307A1 (en) * 2000-06-23 2002-08-15 Glucksmann Maria Alexandra 46508, a novel human peptidyl-tRNA hydrolase family member and uses thereof
DE60140559D1 (en) * 2000-10-05 2009-12-31 Millenium Pharmaceuticals Inc 32144, A HUMAN FATTY ACID HYDROLASE AND ITS USES
US7179606B2 (en) * 2001-11-23 2007-02-20 Syn X Pharma, Inc. IG heavy chain, IG kappa, IG lambda biopolymer markers predictive of Alzheimer's disease
US7074576B2 (en) * 2001-11-23 2006-07-11 Syn X Pharma, Inc. Protein biopolymer markers indicative of alzheimer's disease
WO2013024467A2 (en) * 2011-08-18 2013-02-21 Ecole Polytechnique Federale De Lausanne (Epfl) Mitochondrial ribosomal proteins as aging regulators
CN109311955B (en) * 2016-08-19 2022-09-23 武汉华大吉诺因生物科技有限公司 Novel tumor specific polypeptide and application thereof

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998023744A1 (en) * 1996-11-26 1998-06-04 Incyte Pharmaceuticals, Inc. Novel human rna-binding protein
WO2000055173A1 (en) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. Human breast and ovarian cancer associated gene sequences and polypeptides
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'
WO2001087917A1 (en) * 2000-05-18 2001-11-22 Hyseq, Inc. Novel nucleic acids and polypeptides

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998023744A1 (en) * 1996-11-26 1998-06-04 Incyte Pharmaceuticals, Inc. Novel human rna-binding protein
WO2000055173A1 (en) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. Human breast and ovarian cancer associated gene sequences and polypeptides
WO2000055174A1 (en) * 1999-03-12 2000-09-21 Human Genome Sciences, Inc. Human prostate cancer associated gene sequences and polypeptides
WO2000058473A2 (en) * 1999-03-31 2000-10-05 Curagen Corporation Nucleic acids including open reading frames encoding polypeptides; 'orfx'
WO2001087917A1 (en) * 2000-05-18 2001-11-22 Hyseq, Inc. Novel nucleic acids and polypeptides

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
"Three novel components of the human exosome.", JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 276, no. 9, 2 March 2001 (2001-03-02), pages 6177 - 6184, XP002187892 *
ALLMANG CHRISTINE ET AL: "The yeast exosome and human PM-Scl are related complexes of 3' fwdarw 5' exonucleases.", GENES & DEVELOPMENT, vol. 13, no. 16, 15 August 1999 (1999-08-15), pages 2148 - 2158, XP002187891, ISSN: 0890-9369 *
DATABASE EMBL 10 July 2000 (2000-07-10), BROUWER R., ET AL.: "Homo sapiens exosome component Rrp41 mRNA, complete cds.", XP002187898 *
DATABASE EMBL 22 February 2000 (2000-02-22), SUGANO S., ET AL.: "Homo sapiens cDNA FLJ20591 fis, clone KAT09018.", XP002187893 *
DATABASE EMBL 23 March 2000 (2000-03-23), "hg16h04.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone IMAGE:2945815 3' similar to WP:B0564.1 CE20469 RIBONUCLEASE PH-LIKE PROTEIN B0564.1 ;, mRNA sequence.", XP002187894 *
DATABASE EMBL 30 June 1999 (1999-06-30), "wi79c09.x1 NCI_CGAP_Kid12 Homo sapiens cDNA clone IMAGE:2399536 3' similar to WP:B0564.1 CE05175 RIBONUCLEASE PH-LIKE PROTEIN B0564.1 ;, mRNA", XP002187897 *
DATABASE EMBL 5 May 1999 (1999-05-05), "wb30d08.x1 NCI_CGAP_GC6 Homo sapiens cDNA clone IMAGE:2307183 3' similar to WP:B0564.1 CE05175 RIBONUCLEASE PH-LIKE PROTEIN B0564.1 ;, mRNA sequence.", XP002187895 *
DATABASE EMBL 5 November 1997 (1997-11-05), FISCHER, U., ET AL.: "Homo sapiens survival of motor neuron protein interacting protein 1 (SIP1) mRNA, complete cds.", XP002188024 *
DATABASE EMBL 7 January 1999 (1999-01-07), "qp51h02.x1 NCI_CGAP_Co8 Homo sapiens cDNA clone IMAGE:1926579 3' similar to WP:B0564.1 CE05175 RIBONUCLEASE PH LIKE ;, mRNA sequence.", XP002187896 *
LIU QING ET AL: "The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins.", CELL, vol. 90, no. 6, 1997, pages 1013 - 1021, XP002187934 *

Also Published As

Publication number Publication date
WO2001083524A2 (en) 2001-11-08
EP1278843A2 (en) 2003-01-29
CA2407435A1 (en) 2001-11-08
AU2001257427A1 (en) 2001-11-12
JP2004511208A (en) 2004-04-15

Similar Documents

Publication Publication Date Title
WO2002063005A3 (en) Lipid-associated molecules
WO2001096546A3 (en) Protein phosphatases
WO2002097060A3 (en) Carbohydrate-associated proteins
WO2002010363A3 (en) Protein phosphatases
WO2003054219A3 (en) Nucleic acid-associated proteins
WO2001085942A3 (en) Cytoskeleton-associated proteins
WO2004044165A3 (en) Lipid-associated proteins
WO2001083524A3 (en) Rna metabolism proteins
WO2002024924A3 (en) Protein phosphatases
WO2002066646A3 (en) Neurotransmission-associated proteins
WO2003038052A3 (en) Nucleic acid-associated proteins
WO2003010329A3 (en) Nucleic acid-associated proteins
WO2001064907A3 (en) Lipid metabolism enzymes
WO2000023466A3 (en) Human rna binding proteins
WO2002099115A3 (en) Nucleic acid-associated proteins
WO2003016549A3 (en) Nucleic-acid associated proteins
WO2001085956A3 (en) Lipid metabolism enzymes
WO2000071679A3 (en) Human oxidoreductase proteins
WO2002083873A3 (en) Enzymes
WO2003006618A3 (en) Nucleic acid-associated proteins
WO2004022705A3 (en) Neurotransmission-associated proteins
WO2000078952A8 (en) Human rna metabolism proteins (rmep)
WO2001081590A3 (en) Protein phosphatases
WO2003052048A3 (en) Nucleic acid-associated proteins
WO2002079389A3 (en) Nucleic acid-associated proteins

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
AK Designated states

Kind code of ref document: A3

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BY BZ CA CH CN CR CU CZ DE DK DM DZ EE ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NO NZ PL PT RO RU SD SE SG SI SK SL TJ TM TR TT TZ UA UG US UZ VN YU ZA ZW

AL Designated countries for regional patents

Kind code of ref document: A3

Designated state(s): GH GM KE LS MW MZ SD SL SZ TZ UG ZW AM AZ BY KG KZ MD RU TJ TM AT BE CH CY DE DK ES FI FR GB GR IE IT LU MC NL PT SE TR BF BJ CF CG CI CM GA GN GW ML MR NE SN TD TG

REG Reference to national code

Ref country code: DE

Ref legal event code: 8642

WWE Wipo information: entry into national phase

Ref document number: 2407435

Country of ref document: CA

ENP Entry into the national phase

Ref country code: JP

Ref document number: 2001 580948

Kind code of ref document: A

Format of ref document f/p: F

WWE Wipo information: entry into national phase

Ref document number: 2001930939

Country of ref document: EP

WWP Wipo information: published in national office

Ref document number: 2001930939

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 10258662

Country of ref document: US

WWW Wipo information: withdrawn in national office

Ref document number: 2001930939

Country of ref document: EP