DE69432422D1 - Methoden zum aufspüren von anti-östrogenverbindungen - Google Patents

Methoden zum aufspüren von anti-östrogenverbindungen

Info

Publication number
DE69432422D1
DE69432422D1 DE69432422T DE69432422T DE69432422D1 DE 69432422 D1 DE69432422 D1 DE 69432422D1 DE 69432422 T DE69432422 T DE 69432422T DE 69432422 T DE69432422 T DE 69432422T DE 69432422 D1 DE69432422 D1 DE 69432422D1
Authority
DE
Germany
Prior art keywords
compounds
methods
detecting anti
reporter gene
estrogen compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69432422T
Other languages
English (en)
Other versions
DE69432422T2 (de
Inventor
Peter Kushner
Paul Webb
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of California
Original Assignee
University of California
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of California filed Critical University of California
Application granted granted Critical
Publication of DE69432422D1 publication Critical patent/DE69432422D1/de
Publication of DE69432422T2 publication Critical patent/DE69432422T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/743Steroid hormones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52Purines, e.g. adenine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/721Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6897Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids involving reporter genes operably linked to promoters
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/72Assays involving receptors, cell surface antigens or cell surface determinants for hormones
    • G01N2333/723Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
DE69432422T 1993-09-01 1994-09-01 Methoden zum aufspüren von anti-östrogenverbindungen Expired - Fee Related DE69432422T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US115161 1987-10-30
US11516193A 1993-09-01 1993-09-01
PCT/US1994/009898 WO1995006754A1 (en) 1993-09-01 1994-09-01 Methods for screening antiestrogen compounds

Publications (2)

Publication Number Publication Date
DE69432422D1 true DE69432422D1 (de) 2003-05-08
DE69432422T2 DE69432422T2 (de) 2004-03-04

Family

ID=22359653

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69432422T Expired - Fee Related DE69432422T2 (de) 1993-09-01 1994-09-01 Methoden zum aufspüren von anti-östrogenverbindungen

Country Status (9)

Country Link
EP (1) EP0724648B1 (de)
JP (1) JP3503945B2 (de)
KR (1) KR100355647B1 (de)
AT (1) ATE236247T1 (de)
AU (1) AU682398B2 (de)
CA (1) CA2169466A1 (de)
DE (1) DE69432422T2 (de)
NO (1) NO960715D0 (de)
WO (1) WO1995006754A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5723291A (en) * 1993-09-01 1998-03-03 The Regents Of The University Of California Methods for screening compounds for estrogenic activity
US6156723A (en) 1993-09-01 2000-12-05 The Regents Of The University Of California Compositions comprising inhibitors of estrogen response
GB9424497D0 (en) * 1994-12-05 1995-01-25 Karobio Ab Reporter cell line
WO1997034144A1 (de) * 1996-03-14 1997-09-18 Schering Aktiengesellschaft Verfahren zum nachweis der wirkung von testsubstanzen unter verwendung von hühner-urokinase
US5965543A (en) * 1996-04-18 1999-10-12 Geron Corporation Senescence responsive transcriptional element
US6051417A (en) * 1996-08-06 2000-04-18 Calydon, Inc. Prostate cancer drug screening using hKLK2 enhancer
US5783435A (en) * 1996-08-06 1998-07-21 Lamparski; Henry G. Prostate cancer drug screenings
EP1045035B1 (de) * 1999-04-14 2006-09-20 Sumitomo Chemical Company, Limited Zelle zur Bestimmung der Fähigkeit die Aktivität eines Liganden-abhängigen Transkriptionskontrollfaktors zu kontrollieren
US20110195420A1 (en) * 2008-10-09 2011-08-11 Merck Patent Gesellschaft Estrogen and anti-estrogen marker genes

Also Published As

Publication number Publication date
EP0724648A1 (de) 1996-08-07
ATE236247T1 (de) 2003-04-15
EP0724648B1 (de) 2003-04-02
DE69432422T2 (de) 2004-03-04
JPH09502345A (ja) 1997-03-11
KR100355647B1 (ko) 2002-12-28
NO960715L (no) 1996-02-22
JP3503945B2 (ja) 2004-03-08
AU682398B2 (en) 1997-10-02
CA2169466A1 (en) 1995-03-09
NO960715D0 (no) 1996-02-22
EP0724648A4 (de) 1996-10-09
WO1995006754A1 (en) 1995-03-09
AU7719094A (en) 1995-03-22

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee