LT2494039T - Ląstelių perprogramavimo būdai ir jų panaudojimas - Google Patents

Ląstelių perprogramavimo būdai ir jų panaudojimas

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Publication number
LT2494039T
LT2494039T LTEP10825907.8T LT10825907T LT2494039T LT 2494039 T LT2494039 T LT 2494039T LT 10825907 T LT10825907 T LT 10825907T LT 2494039 T LT2494039 T LT 2494039T
Authority
LT
Lithuania
Prior art keywords
methods
reprogramming cells
reprogramming
cells
Prior art date
Application number
LTEP10825907.8T
Other languages
English (en)
Inventor
Jan-Eric Ahlfors
Rouwayda Elayoubi
Original Assignee
Genesis Technologies Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genesis Technologies Limited filed Critical Genesis Technologies Limited
Publication of LT2494039T publication Critical patent/LT2494039T/lt

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Families Citing this family (72)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7642091B2 (en) 2005-02-24 2010-01-05 Jau-Nan Lee Human trophoblast stem cells and use thereof
US9453205B2 (en) 2009-10-31 2016-09-27 Genesis Technologies Limited Methods for reprogramming cells and uses thereof
US20140038291A1 (en) 2009-10-31 2014-02-06 New World Laboratories Inc. Methods for reprogramming cells and uses thereof
CA2779310C (en) * 2009-10-31 2021-11-30 New World Laboratories Inc. Methods for reprogramming cells and uses thereof
US9228170B2 (en) * 2010-02-05 2016-01-05 Auckland Uniservices Limited Cell programming
JP6163104B2 (ja) * 2010-11-15 2017-07-12 アクセラレイテッド・バイオサイエンシズ・コーポレーション ヒト・トロホブラスト幹細胞からの神経幹細胞の生成
KR102703637B1 (ko) 2010-12-22 2024-09-05 페이트 세러퓨틱스, 인코포레이티드 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
KR101376635B1 (ko) * 2011-01-14 2014-03-24 한국생명공학연구원 Ｒｅｘ１을 포함하는 세포 리프로그래밍 조성물 및 이를 이용한 유도만능줄기세포 제조방법
WO2013013105A2 (en) * 2011-07-19 2013-01-24 Vivoscript,Inc. Compositions and methods for re-programming cells without genetic modification for repairing cartilage damage
US9428730B2 (en) 2012-02-29 2016-08-30 Mead Johnson Nutrition Company Coatings and culture media for promoting neurogenesis in adipose tissue derived stem cells
US20130224782A1 (en) * 2012-02-29 2013-08-29 Chenzhong Kuang Neurogenesis screening method and system using adipose tissue derived stem cells
GB201118964D0 (en) * 2011-11-03 2011-12-14 Ucl Business Plc Method
AU2012350353B2 (en) * 2011-12-13 2018-01-04 Unisa Ventures Pty Ltd Method of producing multipotent stem cells
CN102604894B (zh) * 2012-02-29 2014-07-30 中国科学院广州生物医药与健康研究院 用于制备神经干细胞的培养基及其用途
WO2013138368A1 (en) * 2012-03-12 2013-09-19 Loma Linda University Medical Center Substances and methods for the treatment of cerebral amyloid angiopathy related conditions or diseases
US10561742B2 (en) 2012-07-19 2020-02-18 The Penn State Research Foundation Methods and compositions for treatment of disease or injury of the nervous system
US20140134139A1 (en) * 2012-11-07 2014-05-15 Northwestern University Cd34+ cells and methods of use
CN105143445B (zh) 2012-11-29 2020-07-07 宝生物欧洲公司 衍生自人多能干细胞的肝细胞样细胞的成熟
CN113604423A (zh) 2012-11-30 2021-11-05 艾克塞利瑞提德生物技术公司 通过调节mir-124分化干细胞的方法
EP2938196B1 (en) * 2012-12-14 2019-04-03 Celularity, Inc. Anoikis resistant placental stem cells and uses thereof
AU2013362880B2 (en) * 2012-12-17 2019-01-17 Vashe CHANDRAKANTHAN Methods of generating cells with multilineage potential
PT2970890T (pt) * 2013-03-14 2020-04-24 Massachusetts Inst Technology Composições e métodos para expansão e cultura de células estaminais epiteliais
US20160032317A1 (en) * 2013-03-14 2016-02-04 Children's Medical Center Corporation Compositions and methods for reprogramming hematopoietic stem cell lineages
WO2014170488A1 (en) * 2013-04-19 2014-10-23 Universita' Degli Studi Di Milano Methods for the conversion of somatic cells into pancreatic-hormone secreting cells
KR101655383B1 (ko) 2013-07-27 2016-09-08 고려대학교 산학협력단 소분자 화합물을 포함하는 만능성 줄기세포의 염색체 안정성 유지용 조성물
CA2926372C (en) * 2013-10-10 2023-09-26 Mcmaster University Diagnosis and monitoring of endometriosis through bdnf and full-length ntrk2 levels
US20160298080A1 (en) * 2013-12-03 2016-10-13 The Johns Hopkins University Method for highly efficient conversion of human stem cells to lineage-specific neurons
US9512406B2 (en) 2013-12-20 2016-12-06 The J. David Gladstone Institute, a testamentary trust established under the Will of J. David Gladstone Generating hepatocytes
FR3016372B1 (fr) * 2014-01-13 2018-01-19 Centre Leon Berard Procede de preparation de cellules pluripotentes induites
JP2017509322A (ja) * 2014-01-29 2017-04-06 ヘルムホルツ ツェントゥルム ミュンヘン ドイチェス フォルシュングスツェントゥルム フューア ゲズントハイト ウント ウムヴェルト （ゲーエムベーハー） 分化細胞の分化転換
EP3114214B1 (en) 2014-03-04 2023-11-01 Fate Therapeutics, Inc. Improved reprogramming methods and cell culture platforms
US20150353623A1 (en) * 2014-04-03 2015-12-10 Loma Linda University Substances and methods for the treatment of cerebral amyloid angiopathy related conditions or diseases
US9259357B2 (en) 2014-04-16 2016-02-16 Loma Linda University Composition, preparation, and use of chitosan shards for biomedical applications
KR101731624B1 (ko) * 2014-07-01 2017-05-04 광주과학기술원 세포 리프로그래밍 유도용 조성물
KR20230019500A (ko) 2014-09-03 2023-02-08 더 브리검 앤드 우먼즈 하스피털, 인크. 청력 손실의 치료를 위해 내이 털세포를 생성하기 위한 조성물, 시스템, 및 방법
US9730975B2 (en) 2014-11-25 2017-08-15 The Penn State Research Foundation Chemical reprogramming of human glial cells into neurons for brain and spinal cord repair
JP6836990B2 (ja) 2014-11-26 2021-03-03 アクセラレイテッド・バイオサイエンシズ・コーポレーション 誘導肝細胞およびそれらの使用
MA41296A (fr) * 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
US10839509B2 (en) 2015-07-10 2020-11-17 3Scan Inc. Spatial multiplexing of histological stains
CN105062953A (zh) * 2015-08-06 2015-11-18 深圳爱生再生医学科技有限公司 三维诱导间充质干细胞转化为胰岛细胞的方法
KR20180055918A (ko) 2015-10-16 2018-05-25 페이트 세러퓨틱스, 인코포레이티드 기저 상태 다능성의 유도 및 유지를 위한 플랫폼
JP2019506153A (ja) 2016-01-08 2019-03-07 マサチューセッツ インスティテュート オブ テクノロジー 分化した腸内分泌細胞およびインスリン産生細胞の作製
US10973930B2 (en) 2016-02-18 2021-04-13 The Penn State Research Foundation Generating GABAergic neurons in brains
US10201540B2 (en) 2016-03-02 2019-02-12 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using GSK3 inhibitors: I
US11260130B2 (en) 2016-03-02 2022-03-01 Frequency Therapeutics, Inc. Solubilized compositions for controlled proliferation of stem cells / generating inner ear hair cells using a GSK3 inhibitor: IV
US10213511B2 (en) 2016-03-02 2019-02-26 Frequency Therapeutics, Inc. Thermoreversible compositions for administration of therapeutic agents
CN107142240B (zh) * 2016-06-03 2021-01-29 中国人民解放军军事医学科学院野战输血研究所 将消化道来源上皮细胞重编程为内胚层干/祖细胞的方法及应用
CN105861447B (zh) * 2016-06-13 2017-12-19 广州市搏克生物技术有限公司 一种非病毒iPSCs诱导组合物及其试剂盒
JP7118901B2 (ja) 2016-06-20 2022-08-16 ジェネシス テクノロジーズ リミティド 自動化された細胞加工システム及び方法
CA3048220A1 (en) 2016-12-30 2018-07-05 Frequency Therapeutics, Inc. 1h-pyrrole-2,5-dione compounds and methods of using them to induce self-renewal of stem/progenitor supporting cells
CA3054120A1 (en) * 2017-02-24 2018-08-30 Koji Tanabe Nerve cell production method by introduction of inducing factor rna
CN111471653B (zh) * 2017-03-01 2022-11-25 中国科学院动物研究所 一种将非神经元细胞转化为神经元细胞的方法
AU2017421792B2 (en) * 2017-06-30 2022-03-10 Stemlab Inc. Method for directly reprogramming cells in urine into keratinocyte stem cells and method for preparing composition for promoting skin regeneration by using reprogrammed keratinocyte stem cells
US20210230550A1 (en) * 2018-01-29 2021-07-29 Institute Of Zoology, Chinese Academy Of Sciences Cell induction method
CN110093310B (zh) * 2018-01-29 2021-07-02 中国科学院动物研究所 一种将成纤维细胞转化为永生化细胞的方法及其应用
CN110093309B (zh) * 2018-01-29 2021-07-02 中国科学院动物研究所 一种诱导成纤维细胞转分化为脂肪细胞的方法
CN110093305B (zh) * 2018-01-29 2021-07-02 中国科学院动物研究所 一种诱导肝细胞体外扩增的方法
CA3087869A1 (en) * 2018-02-02 2019-08-08 The Penn State Research Foundation Methods and materials for treating brain injuries
CN110305846A (zh) * 2018-03-20 2019-10-08 中山大学中山眼科中心 视网膜节细胞的制备方法
SG11202011395RA (en) * 2018-06-22 2020-12-30 Skin2Neuron Pty Ltd Expansion and differentiation of neuronal precursor cells
AU2019321641A1 (en) 2018-08-17 2021-04-15 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by upregulating Jag-1
WO2020037326A1 (en) 2018-08-17 2020-02-20 Frequency Therapeutics, Inc. Compositions and methods for generating hair cells by downregulating foxo
AU2019343166A1 (en) * 2018-09-19 2021-05-20 Regeneration Biomedical, Inc. WNT-activated adipose-derived stem cell apparatuses, methods and systems
US11518971B2 (en) 2018-11-27 2022-12-06 Research Triangle Institute Method and apparatus for spatial control of cellular growth
JP7285591B2 (ja) * 2019-01-02 2023-06-02 セラピューティクス バイオ 体細胞から分化した新規な神経膠様細胞、その製造方法、その製造用カクテル組成物、これを含む神経疾患の予防または治療用細胞治療剤およびこれを投与して神経疾患を予防および治療する方法
US20220110979A1 (en) * 2019-01-11 2022-04-14 Figene, Llc Fibroblast regenerative cells
AU2020268341A1 (en) 2019-05-06 2021-12-02 Accelerated Biosciences Corp. Precursory regulatory cytotrophoblast cells and uses thereof
KR102183208B1 (ko) * 2019-07-25 2020-11-25 한국과학기술연구원 Ngn2(neurogenin-2)를 이용하여 척수 손상 모델에서 반응성 성상세포를 신경세포로 리프로그래밍하는 방법
AU2020402020A1 (en) * 2019-12-09 2022-06-23 The Brigham And Women's Hospital, Inc. Methods for generating hematopoietic stem cells
CN111471651A (zh) * 2020-04-24 2020-07-31 中国人民解放军第四军医大学 一种人脂肪干细胞无血清培养基及其制备方法
CN113862218B (zh) * 2021-10-12 2024-06-25 广州医科大学附属第一医院（广州呼吸中心） 一种肿瘤相关性血管周细胞亚群及制备方法与应用
US20230257969A1 (en) * 2022-02-16 2023-08-17 Caterpillar Inc. Adapter retention plug

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6087168A (en) 1999-01-20 2000-07-11 Cedars Sinai Medical Center Conversion of non-neuronal cells into neurons: transdifferentiation of epidermal cells
US20020136709A1 (en) 2000-12-12 2002-09-26 Nucleus Remodeling, Inc. In vitro-derived adult pluripotent stem cells and uses therefor
AU2002313817A1 (en) * 2001-08-27 2003-03-10 Advanced Cell Technology, Inc. Trans-differentiation and re-differentiation of somatic cells and production of cells for cell therapies
US20030217378A1 (en) 2002-04-05 2003-11-20 The University Of Georgia Research Foundation, Inc Cloning using rapidly matured oocytes
US7732203B2 (en) * 2002-08-17 2010-06-08 Ajoll University Industry Cooperation Foundation Method for transdifferentiating mesenchymal stem cells into neuronal cells
US8178349B2 (en) 2005-02-09 2012-05-15 Burnham Institute For Medical Research Homogeneous neural precursor cells
US8440460B2 (en) 2005-07-27 2013-05-14 The Board Of Regents Of The University Of Texas System Methods for transdifferentiating cells
CN101389761A (zh) 2006-02-27 2009-03-18 银怎株式会社 使用bmi-1使星形胶质细胞去分化成为神经干细胞
AU2007332799A1 (en) * 2006-12-07 2008-06-19 Teva Pharmaceutical Industries Ltd. Method of generation and expansion of tissue-progenitor cells and mature tissue cells from intact bone marrow or intact umbilical cord tissue
WO2009018832A1 (en) * 2007-08-09 2009-02-12 Rigshospitalet Method for increasing the plasticity level of a cell
RU2492232C2 (ru) * 2007-08-31 2013-09-10 Уайтхэд Инститьют Фор Байомедикал Рисерч СТИМУЛЯЦИЯ ПУТИ Wnt ПРИ ПЕРЕПРОГРАММИРОВАНИИ СОМАТИЧЕСКИХ КЛЕТОК
CA2660123C (en) 2007-10-31 2017-05-09 Kyoto University Nuclear reprogramming method
US20090136461A1 (en) * 2007-11-28 2009-05-28 Moon Suk Kim Neuronal differentiation method of adult stem cells using small molecules
EP2245140A2 (en) * 2007-11-30 2010-11-03 New York Medical College Compositions comprising hdac inhibitors and methods of their use in restoring stem cell function and preventing heart failure
AU2008338989A1 (en) 2007-12-17 2009-06-25 Gliamed, Inc. Stem-like cells and method for reprogramming adult mammalian somatic cells
WO2009117439A2 (en) * 2008-03-17 2009-09-24 The Scripps Research Institute Combined chemical and genetic approaches for generation of induced pluripotent stem cells
JP2011516082A (ja) * 2008-04-07 2011-05-26 ニューポテンシャル，インコーポレイテッド 小分子修飾因子の使用を通して多能性遺伝子を誘発することによる細胞の再プログラミング
JP5608645B2 (ja) 2008-11-05 2014-10-15 学校法人慶應義塾 神経幹細胞製造方法
EP2393915A4 (en) 2009-02-05 2012-12-26 Regenertech Pty Ltd PROCESS FOR THE PREPARATION OF PRECURSOR CELLS FROM DIFFERENTIATED CELLS
WO2010124143A1 (en) * 2009-04-23 2010-10-28 Nevada Cancer Institute Reprogramming of somatic cells with purified proteins
JP5921430B2 (ja) * 2009-05-20 2016-05-24 マヨ ファウンデーション フォー メディカル エデュケーション アンド リサーチＭａｙｏ Ｆｏｕｎｄａｔｉｏｎ Ｆｏｒ Ｍｅｄｉｃａｌ Ｅｄｕｃａｔｉｏｎ Ａｎｄ Ｒｅｓｅａｒｃｈ 哺乳類細胞の心臓発生能を決定する方法
CA2779310C (en) * 2009-10-31 2021-11-30 New World Laboratories Inc. Methods for reprogramming cells and uses thereof
US9453205B2 (en) * 2009-10-31 2016-09-27 Genesis Technologies Limited Methods for reprogramming cells and uses thereof
US20130097717A1 (en) * 2010-06-23 2013-04-18 Vivoscript, Inc. Compositions and methods for re-programming cells without genetic modification for treatment of cardiovascular diseases
WO2013033213A1 (en) * 2011-08-30 2013-03-07 The J. David Gladstone Institutes Methods for generating cardiomyocytes
US9540612B2 (en) 2012-01-30 2017-01-10 Icahn School Of Medicine At Mount Sinai Methods for programming differentiated cells into hematopoietic stem cells

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