MA41296A - Procédés de transdifférenciation et procédés d'utilisation de ceux-ci - Google Patents

Procédés de transdifférenciation et procédés d'utilisation de ceux-ci

Info

Publication number
MA41296A
MA41296A MA041296A MA41296A MA41296A MA 41296 A MA41296 A MA 41296A MA 041296 A MA041296 A MA 041296A MA 41296 A MA41296 A MA 41296A MA 41296 A MA41296 A MA 41296A
Authority
MA
Morocco
Prior art keywords
methods
same
transdifferentiation
processes
transdifferentiation processes
Prior art date
Application number
MA041296A
Other languages
English (en)
Inventor
Sarah Ferber
Original Assignee
Orgenesis Ltd
Tel Hashomer Medical Res Infrastructure & Services Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Orgenesis Ltd, Tel Hashomer Medical Res Infrastructure & Services Ltd filed Critical Orgenesis Ltd
Publication of MA41296A publication Critical patent/MA41296A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/39—Pancreas; Islets of Langerhans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C12N15/861—Adenoviral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/14—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from hepatocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/10011—Adenoviridae
    • C12N2710/10311—Mastadenovirus, e.g. human or simian adenoviruses
    • C12N2710/10341—Use of virus, viral particle or viral elements as a vector
    • C12N2710/10343—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Toxicology (AREA)
  • Emergency Medicine (AREA)
MA041296A 2014-12-30 2015-12-29 Procédés de transdifférenciation et procédés d'utilisation de ceux-ci MA41296A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201462098050P 2014-12-30 2014-12-30

Publications (1)

Publication Number Publication Date
MA41296A true MA41296A (fr) 2017-11-07

Family

ID=56284403

Family Applications (1)

Application Number Title Priority Date Filing Date
MA041296A MA41296A (fr) 2014-12-30 2015-12-29 Procédés de transdifférenciation et procédés d'utilisation de ceux-ci

Country Status (15)

Country Link
US (3) US10179151B2 (fr)
EP (2) EP3240576B1 (fr)
JP (1) JP6817943B2 (fr)
KR (1) KR102487883B1 (fr)
CN (1) CN107750170B (fr)
AU (1) AU2015373129B2 (fr)
BR (1) BR112017014280A2 (fr)
CA (1) CA2972569A1 (fr)
CO (1) CO2017006937A2 (fr)
EA (1) EA035360B1 (fr)
IL (1) IL253234B (fr)
MA (1) MA41296A (fr)
MX (1) MX2017008669A (fr)
SG (1) SG11201705344VA (fr)
WO (1) WO2016108237A1 (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2915143C (fr) 2013-06-13 2021-08-03 Orgenesis Ltd. Populations cellulaires, procedes de transdifferenciation et leurs procedes d'utilisation
AU2014326794B2 (en) 2013-09-24 2019-03-21 Giner, Inc. System for gas treatment of a cell implant
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
CA3023221A1 (fr) 2016-05-05 2017-11-09 Southwest Research Institute Bioreacteur tridimensionnel pour expansion cellulaire et applications associees
BR112019009712A2 (pt) 2016-11-15 2019-08-13 Giner Life Sciences Inc dispositivo de difusão gasosa percutânea adequado para uso com um implante subcutâneo
CN110831656A (zh) 2017-05-04 2020-02-21 吉纳生命科学公司 稳健的可植入气体递送装置和方法、系统以及包括该装置的装置
EP3635106A4 (fr) * 2017-05-08 2021-01-06 Orgenesis Ltd. Populations de cellules transdifférenciées et leurs procédés d'utilisation
WO2018220623A1 (fr) * 2017-05-29 2018-12-06 Orgenesis Ltd. Compositions et procédés de fourniture de thérapie de remplacement cellulaire
EP3694985A1 (fr) 2017-10-13 2020-08-19 IMBA-Institut für Molekulare Biotechnologie GmbH Reprogrammation améliorée de cellules somatiques
EP3761999A4 (fr) * 2018-03-06 2021-11-17 Orgenesis Ltd. Groupes tridimensionnels de cellules transdifférenciées, compositions et procédés associés
US11149244B2 (en) 2018-04-04 2021-10-19 Southwest Research Institute Three-dimensional bioreactor for T-cell activation and expansion for immunotherapy
AU2019346419B2 (en) 2018-09-24 2023-08-17 Southwest Research Institute Three-dimensional bioreactors
EP3816276A1 (fr) * 2019-10-31 2021-05-05 Unicyte Islet AG Structures de cellules de type îlots pancréatiques viables et leur procédé de préparation

Family Cites Families (71)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4522811A (en) 1982-07-08 1985-06-11 Syntex (U.S.A.) Inc. Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
US4980286A (en) 1985-07-05 1990-12-25 Whitehead Institute For Biomedical Research In vivo introduction and expression of foreign genetic material in epithelial cells
US4737323A (en) 1986-02-13 1988-04-12 Liposome Technology, Inc. Liposome extrusion method
DE122007000007I2 (de) 1986-04-09 2010-12-30 Genzyme Corp Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern
US4837028A (en) 1986-12-24 1989-06-06 Liposome Technology, Inc. Liposomes with enhanced circulation time
US4873316A (en) 1987-06-23 1989-10-10 Biogen, Inc. Isolation of exogenous recombinant proteins from the milk of transgenic mammals
US4992417A (en) 1987-07-17 1991-02-12 Mount Sinai School Of Medicine Superactive human insulin analogues
US5082670A (en) 1988-12-15 1992-01-21 The Regents Of The University Of California Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5328470A (en) 1989-03-31 1994-07-12 The Regents Of The University Of Michigan Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor
US5427940A (en) 1991-06-03 1995-06-27 Board Of Regents, The University Of Texas System Engineered cells producing insulin in response to glucose
DK0671923T3 (da) 1992-10-09 2001-08-13 Advanced Tissue Sciences Inc Leverreserveceller
US5523226A (en) 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
US5424286A (en) 1993-05-24 1995-06-13 Eng; John Exendin-3 and exendin-4 polypeptides, and pharmaceutical compositions comprising same
EP0714438B1 (fr) 1993-08-16 2007-09-19 RESEARCH DEVELOPMENT FOUNDATION (a Nevada corporation) Nouveau facteur d'homeosequence stimulant l'expression de l'insuline dans les cellules des ilots pancreatiques
US5858973A (en) 1994-02-23 1999-01-12 The General Hospital Corporation Transcription factor and uses therefor
IL114193A (en) 1994-06-20 2000-02-29 Teva Pharma Ophthalmic pharmaceutical compositions based on sodium alginate
US5849989A (en) 1994-10-07 1998-12-15 Ontogeny, Inc. Insulin promoter factor, and uses related thereto
JP2000501290A (ja) 1995-11-30 2000-02-08 リサーチ ディベロップメント ファンデーション ソマトスタチン及びインシュリン生成を刺激する化合物のスクリーニング・アッセイ
IL118376A0 (en) 1996-05-22 1996-09-12 Univ Ben Gurion Polysaccharide sponges for cell culture and transplantation
JP2000513227A (ja) 1996-06-24 2000-10-10 ビーボウアールエックス ファーマスーティカルズ，インコーポレイテッド インスリン分泌細胞の単離および増殖方法
EP0996736A1 (fr) 1997-08-11 2000-05-03 Chiron Corporation Methodes de modification genetique de lymphocytes t
CA2221195A1 (fr) 1997-11-14 1999-05-14 Chantal E. Holy Matrice en polymere biodegradable
US6143293A (en) 1998-03-26 2000-11-07 Carnegie Mellon Assembled scaffolds for three dimensional cell culturing and tissue generation
IL124957A0 (en) 1998-06-16 1999-01-26 Univ Ben Gurion Active ingredient delivery systems and devices based on porous matrices
US6242666B1 (en) 1998-12-16 2001-06-05 The Scripps Research Institute Animal model for identifying a common stem/progenitor to liver cells and pancreatic cells
US6774120B1 (en) 1999-06-01 2004-08-10 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US8778899B2 (en) 1999-06-01 2014-07-15 Sarah Ferber Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues
US6716824B1 (en) 1999-10-22 2004-04-06 F. Charles Brunicardi Treatment of pancreatic adenocarcinoma by cytotoxic gene therapy
US6759039B2 (en) 2000-06-30 2004-07-06 Amcyte, Inc. Culturing pancreatic stem cells having a specified, intermediate stage of development
US7214371B1 (en) 2000-09-01 2007-05-08 Ben-Gurion University Of The Negev Research & Development Authority Tissue engineered biografts for repair of damaged myocardium
US7524492B2 (en) 2001-08-31 2009-04-28 Joslin Diabetes Center, Inc. Insulin related transcription factor and uses thereof
WO2003033697A1 (fr) 2001-10-18 2003-04-24 Ixion Biotechnology, Inc. Transformation de cellules souches et progenitrices du foie en cellules fonctionnelles du pancreas
US7722894B2 (en) 2001-10-22 2010-05-25 Massachusetts Institute Of Technology Biodegradable polymer
GB2415432B (en) 2001-12-07 2006-09-06 Geron Corp Islet cells from human embryonic stem cells
US7029915B2 (en) * 2002-02-22 2006-04-18 University Of Florida Research Foundation, Inc. Method for differentiating rat hepatic stem cells to insulin-producing cells
GB0206357D0 (en) 2002-03-18 2002-05-01 Univ Bath Cells
JP4136434B2 (ja) 2002-04-17 2008-08-20 進 清野 インスリン産生細胞の誘導
WO2003102134A2 (fr) 2002-05-28 2003-12-11 Becton, Dickinson And Company Methodes d'expansion et de transdifferentiation in vitro de cellules acineuses pancreatiques humaines en cellules produisant de l'insuline
ES2440654T3 (es) 2003-05-05 2014-01-29 Ben-Gurion University Of The Negev Research And Development Authority Preparaciones poliméricas reticuladas inyectables y usos de las mismas
JP2006525994A (ja) * 2003-05-12 2006-11-16 サラ ファーバー， 非膵島組織における調節された膵ホルモンの産生を誘導する方法
WO2005005607A2 (fr) 2003-06-30 2005-01-20 Lifescan, Inc. Ensemencement de cellules pancreatiques sur des matrices poreuses
WO2005021728A2 (fr) 2003-08-27 2005-03-10 Stemcells California, Inc. Populations de cellules progenitrices et de cellules souches pancreatiques enrichies, methodes d'identification, d'isolement et d'enrichissement de ces populations
WO2005056747A2 (fr) 2003-12-09 2005-06-23 Ben-Gurion University Of The Negev Research And Development Authority Bioreacteur a perfusion a milieu d'impulsion avec moyen de transport de masse ameliore pour constructions cellulaires 3d multiples
WO2006021950A1 (fr) 2004-08-25 2006-03-02 Technion Research & Development Foundation Ltd. Procédé de génération de corps embryoïdes utilisant des échelles tridimensionnelles
US8679484B2 (en) 2005-03-02 2014-03-25 Polyrizon Ltd. Method for removal of toxins from mucosal membranes
US9216236B2 (en) 2005-03-07 2015-12-22 Technion Research & Development Foundation Limited Natural tissue-derived decellularized matrix and methods of generating and using same
US7517856B2 (en) 2005-10-11 2009-04-14 Ben-Gurion University Of The Negev Research And Development Authority Bioconjugates comprising sulfated polysaccharides and their uses
CA2658180A1 (fr) * 2006-07-19 2008-01-31 University Of Florida Research Foundation, Inc. Compositions pour la reprogrammation d'une cellule et leurs utilisations
US9127254B2 (en) 2006-12-18 2015-09-08 Ben-Gurion University Of The Negev Research And Development Authority Scaffolding for tissue regeneration or repair
WO2009007979A2 (fr) 2007-07-11 2009-01-15 Technion Research & Development Foundation Ltd. Cellules souches mésenchymateuses encapsulées et leurs procédés d'utilisation
IL187707A0 (en) 2007-11-27 2008-11-03 Univ Ben Gurion Alginate scaffold in hepatectomy
WO2009126927A2 (fr) * 2008-04-11 2009-10-15 Joslin Diabetes Center, Inc. Procédés de génération de cellules produisant de l'insuline
WO2010022395A2 (fr) * 2008-08-22 2010-02-25 President And Fellows Of Harvard College Procédés de reprogrammation de cellules
WO2011016423A1 (fr) 2009-08-02 2011-02-10 学校法人 東京女子医科大学 Feuillet de cellules de langerhans, procédé de production associé, et application associée
CA2779310C (fr) * 2009-10-31 2021-11-30 New World Laboratories Inc. Procedes de reprogrammation cellulaire et leurs utilisations
JP2011223993A (ja) 2010-03-30 2011-11-10 Kumamoto Univ 幹細胞の分化誘導方法
WO2011159726A2 (fr) 2010-06-14 2011-12-22 The Scripps Research Institute Reprogrammation de cellules pour leur conférer un nouveau destin
JP6063613B2 (ja) 2011-08-09 2017-01-18 イェダ リサーチ アンド デベロップメント カンパニー リミテッド ベータ細胞の分化およびインスリン産生を促進するためのｍｉＲ−７のダウンレギュレーション
WO2013124855A1 (fr) 2012-02-21 2013-08-29 Ben-Gurion University Of The Negev Research And Development Authority Système hydrogel comprenant des polypeptides bioactifs séparés dans l'espace
WO2014102802A1 (fr) 2012-12-30 2014-07-03 Hadasit Medical Research Services And Development Ltd. Compositions d'alginate et leurs utilisations
US20160101133A1 (en) 2013-05-08 2016-04-14 Regenmedtx, Llc Organoids comprising isolated renal cells and use thereof
CA2915143C (fr) * 2013-06-13 2021-08-03 Orgenesis Ltd. Populations cellulaires, procedes de transdifferenciation et leurs procedes d'utilisation
WO2015125147A1 (fr) 2014-02-20 2015-08-27 B. G. Negev Technologies And Applications Ltd Polyplexes anioniques destinés à être utilisés pour l'administration d'acides nucléiques
EP3149067B1 (fr) 2014-05-30 2021-03-17 The Secant Group, LLC Préparations de matériaux polymères à médiation par l'eau
EP3149026A4 (fr) 2014-06-02 2018-01-24 B.G. Negev Technologies and Applications Ltd. Modification régiosélective de polysaccharides et applications associées
MA41296A (fr) * 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
WO2017118979A1 (fr) 2016-01-07 2017-07-13 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Compositions et méthodes pour générer des réponses immunotolérantes
WO2017175229A1 (fr) 2016-04-07 2017-10-12 B.G. Negev Technologies And Applications Ltd. Compositions de polysaccharides et leurs utilisations
US20170290954A1 (en) 2016-04-07 2017-10-12 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Compositions and methods for treating spinal cord injury
EP3635106A4 (fr) 2017-05-08 2021-01-06 Orgenesis Ltd. Populations de cellules transdifférenciées et leurs procédés d'utilisation

Also Published As

Publication number Publication date
EA035360B1 (ru) 2020-06-02
US11617769B2 (en) 2023-04-04
US20200297777A1 (en) 2020-09-24
CN107750170B (zh) 2021-10-08
MX2017008669A (es) 2018-02-16
US10668107B2 (en) 2020-06-02
CN107750170A (zh) 2018-03-02
EP3698803A1 (fr) 2020-08-26
US20190134097A1 (en) 2019-05-09
CA2972569A1 (fr) 2016-07-07
KR20170102308A (ko) 2017-09-08
WO2016108237A1 (fr) 2016-07-07
IL253234A0 (en) 2017-08-31
KR102487883B1 (ko) 2023-01-11
JP2018502574A (ja) 2018-02-01
EP3240576B1 (fr) 2020-03-04
EP3240576A4 (fr) 2018-06-20
US20160220616A1 (en) 2016-08-04
US10179151B2 (en) 2019-01-15
BR112017014280A2 (pt) 2018-03-27
EA201791508A1 (ru) 2018-05-31
IL253234B (en) 2020-04-30
CO2017006937A2 (es) 2017-10-20
JP6817943B2 (ja) 2021-01-20
AU2015373129A1 (en) 2017-08-03
SG11201705344VA (en) 2017-07-28
AU2015373129B2 (en) 2021-07-15
EP3240576A1 (fr) 2017-11-08
EP3698803B1 (fr) 2023-03-08

Similar Documents

Publication Publication Date Title
MA41296A (fr) Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
IL265396A (en) Methods and compositions for detecting analytes
IL259837A (en) Microfluidic devices and kits and their uses
HK1243104A1 (zh) 抗fgfr2/3抗體及其使用方法
MA55748A (fr) Procédés de détection d'aav
MA43365A (fr) Anticorps anti-dr5 et procédés d'utilisation de ceux-ci
EP3271824A4 (fr) Attestation automatisée d'intégrité d'un dispositif à l'aide d'une chaîne de blocs
KR102478638B9 (ko) 진단 방법 및 이를 수행하는 기기
MA41613A (fr) Récepteurs antigéniques chimériques anti-dll3 et procédés d'utilisation desdits récepteurs
HK1256242A1 (zh) 吲哚化合物以及製備和使用該化合物的方法
PL3392931T3 (pl) Separator dla urządzenia elektrochemicznego i urządzenie elektrochemiczne go zawierające
TWI561924B (en) Chemically-amplified negative resist composition and resist patterning process using the same
MA39915A (fr) Composés de pladiénolide pyridine et leurs procédés d'utilisation
MA46059A (fr) Variants de l'endonucléase homing tim3, compositions et procédés d'utilisation
TWI561931B (en) Chemically-amplified positive resist composition and resist patterning process using the same
PL3258660T3 (pl) Urządzenie zabezpieczające i klucz sprzętowy oraz sposób jego używania
MA45047A (fr) Procédés d'utilisation d'inhibiteurs de fasn
GB201615209D0 (en) Catalyst and process using the catalyst
GB2571629B (en) Motor and apparatus using the same
GB201615197D0 (en) Catalyst and process using the catalyst
GB201420222D0 (en) Molecular probes and methods using the same
FR3026388B1 (fr) Atterrisseur d'aeronef
KR101469505B9 (ko) 방습 및 배수를 위한 벽체시공용 클립 및 이를 이용한 벽체 시공 방법
FI11211U1 (fi) Puristinlaite
GB201501411D0 (en) Mass exchange apparatus and methods for the use thereof