MX389666B - Induccion de celulas pluripotentes. - Google Patents

Induccion de celulas pluripotentes.

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Publication number
MX389666B
MX389666B MX2016003993A MX2016003993A MX389666B MX 389666 B MX389666 B MX 389666B MX 2016003993 A MX2016003993 A MX 2016003993A MX 2016003993 A MX2016003993 A MX 2016003993A MX 389666 B MX389666 B MX 389666B
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MX
Mexico
Prior art keywords
inhibitor
rock
induction
pluripotent cells
alk5
Prior art date
Application number
MX2016003993A
Other languages
English (en)
Inventor
Sheng Ding
Tongxiang Lin
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Scripps Research Inst
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Publication date
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Publication of MX389666B publication Critical patent/MX389666B/es

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N2501/065—Modulators of histone acetylation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/09—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from epidermal cells, from skin cells, from oral mucosa cells
    • C12N2506/094—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from epidermal cells, from skin cells, from oral mucosa cells from keratinocytes
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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  • Health & Medical Sciences (AREA)
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  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
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  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La presente invención se refiere a una composición que comprende: un inhibidor de quinasa Rho (ROCK) un inhibidor de ALK5; y un inhibidor de MEK, en donde el inhibidor de ALK5, el inhibidor de MEK y el inhibidor de ROCK están presentes en cantidades efectivas para incrementar la eficiencia de reprogramar una célula de mamífero no pluripotente en una célula pluripotente, en comparación con células de mamífero no pluripotentes tratadas con el inhibidor de ALK5 y el inhibidor de MEK, sin el inhibidor de ROCK.
MX2016003993A 2009-10-16 2010-10-15 Induccion de celulas pluripotentes. MX389666B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25254809P 2009-10-16 2009-10-16
PCT/US2010/052896 WO2011047300A1 (en) 2009-10-16 2010-10-15 Induction of pluripotent cells

Publications (1)

Publication Number Publication Date
MX389666B true MX389666B (es) 2025-03-19

Family

ID=43876590

Family Applications (3)

Application Number Title Priority Date Filing Date
MX2016003993A MX389666B (es) 2009-10-16 2010-10-15 Induccion de celulas pluripotentes.
MX2012004283A MX337982B (es) 2009-10-16 2010-10-15 Induccion de celulas pluripotentes.
MX2021014919A MX2021014919A (es) 2009-10-16 2012-04-12 Induccion de celulas pluripotentes.

Family Applications After (2)

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MX2012004283A MX337982B (es) 2009-10-16 2010-10-15 Induccion de celulas pluripotentes.
MX2021014919A MX2021014919A (es) 2009-10-16 2012-04-12 Induccion de celulas pluripotentes.

Country Status (11)

Country Link
US (5) US9005968B2 (es)
EP (3) EP2488630B1 (es)
JP (7) JP5808331B2 (es)
CN (3) CN102741394B (es)
AU (1) AU2010306627B2 (es)
BR (1) BR112012008848A2 (es)
CA (3) CA2777720C (es)
ES (2) ES2638464T3 (es)
MX (3) MX389666B (es)
RU (1) RU2012117719A (es)
WO (1) WO2011047300A1 (es)

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