BR112012008848A2 - composição, e, método in vitro ou ex vivo para induzir células de mamífero não-pluripotente em células tronco pluripotentes induzidas - Google Patents

composição, e, método in vitro ou ex vivo para induzir células de mamífero não-pluripotente em células tronco pluripotentes induzidas

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Publication number
BR112012008848A2
BR112012008848A2 BR112012008848A BR112012008848A BR112012008848A2 BR 112012008848 A2 BR112012008848 A2 BR 112012008848A2 BR 112012008848 A BR112012008848 A BR 112012008848A BR 112012008848 A BR112012008848 A BR 112012008848A BR 112012008848 A2 BR112012008848 A2 BR 112012008848A2
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BR
Brazil
Prior art keywords
cells
vitro
induced pluripotent
vivo method
stem cells
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BR112012008848A
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English (en)
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Ding Sheng
Lin Tongxiang
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Scripps Research Inst
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Publication date
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Publication of BR112012008848A2 publication Critical patent/BR112012008848A2/pt

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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/065—Modulators of histone acetylation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
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    • C12N2501/999—Small molecules not provided for elsewhere
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/09—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from epidermal cells, from skin cells, from oral mucosa cells
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/28—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from vascular endothelial cells
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    • C12N2510/00—Genetically modified cells

Abstract

composição, e, método in vitro ou ex vivo para induzir células de mamífero não-pluripotente em células tronco pluripotentes induzidas. as cinéticas lentas e eficiência baixa dos métodos de reprogramação para gerar células tranco humanas pluripotentes induzidas (ipscs) impõem limitações maiores na sua utilidade em aplicações biomédicas. aqui nós descrevemos uma aproximação química que dramaticamente melhora (>200 vezes) a eficiência da geração de ipsc a partir de fibroblastos humanos, dentro de sete dias de tratamento. isto fornecerá uma base para o desenvolvimento métodos não virais mais seguros, mais eficientes para a reprogramação de células somáticas humanas.
BR112012008848A 2009-10-16 2010-10-15 composição, e, método in vitro ou ex vivo para induzir células de mamífero não-pluripotente em células tronco pluripotentes induzidas BR112012008848A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25254809P 2009-10-16 2009-10-16
PCT/US2010/052896 WO2011047300A1 (en) 2009-10-16 2010-10-15 Induction of pluripotent cells

Publications (1)

Publication Number Publication Date
BR112012008848A2 true BR112012008848A2 (pt) 2019-09-24

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BR112012008848A BR112012008848A2 (pt) 2009-10-16 2010-10-15 composição, e, método in vitro ou ex vivo para induzir células de mamífero não-pluripotente em células tronco pluripotentes induzidas

Country Status (12)

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US (4) US9005968B2 (pt)
EP (3) EP3235901B1 (pt)
JP (6) JP5808331B2 (pt)
CN (3) CN113621576A (pt)
AU (1) AU2010306627B2 (pt)
BR (1) BR112012008848A2 (pt)
CA (3) CA3194845A1 (pt)
ES (2) ES2938049T3 (pt)
HK (1) HK1175811A1 (pt)
MX (2) MX337982B (pt)
RU (1) RU2012117719A (pt)
WO (1) WO2011047300A1 (pt)

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