HK1175811A1 - 多能細胞的誘導 - Google Patents

多能細胞的誘導

Info

Publication number
HK1175811A1
HK1175811A1 HK13102807.4A HK13102807A HK1175811A1 HK 1175811 A1 HK1175811 A1 HK 1175811A1 HK 13102807 A HK13102807 A HK 13102807A HK 1175811 A1 HK1175811 A1 HK 1175811A1
Authority
HK
Hong Kong
Prior art keywords
induction
pluripotent cells
pluripotent
cells
Prior art date
Application number
HK13102807.4A
Other languages
English (en)
Inventor
林通翔
丁生
Original Assignee
斯克里普斯研究所
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 斯克里普斯研究所 filed Critical 斯克里普斯研究所
Publication of HK1175811A1 publication Critical patent/HK1175811A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0696—Artificially induced pluripotent stem cells, e.g. iPS
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/065—Modulators of histone acetylation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/602—Sox-2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/603—Oct-3/4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/604—Klf-4
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/60—Transcription factors
    • C12N2501/606—Transcription factors c-Myc
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/999—Small molecules not provided for elsewhere
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/09—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from epidermal cells, from skin cells, from oral mucosa cells
    • C12N2506/094—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from epidermal cells, from skin cells, from oral mucosa cells from keratinocytes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/13—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells
    • C12N2506/1307—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from connective tissue cells, from mesenchymal cells from adult fibroblasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/28—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from vascular endothelial cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Developmental Biology & Embryology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Materials For Medical Uses (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HK13102807.4A 2009-10-16 2013-03-06 多能細胞的誘導 HK1175811A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US25254809P 2009-10-16 2009-10-16
PCT/US2010/052896 WO2011047300A1 (en) 2009-10-16 2010-10-15 Induction of pluripotent cells

Publications (1)

Publication Number Publication Date
HK1175811A1 true HK1175811A1 (zh) 2013-07-12

Family

ID=43876590

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13102807.4A HK1175811A1 (zh) 2009-10-16 2013-03-06 多能細胞的誘導

Country Status (12)

Country Link
US (4) US9005968B2 (zh)
EP (3) EP3235901B1 (zh)
JP (7) JP5808331B2 (zh)
CN (3) CN113621576A (zh)
AU (1) AU2010306627B2 (zh)
BR (1) BR112012008848A2 (zh)
CA (3) CA3091210C (zh)
ES (2) ES2638464T3 (zh)
HK (1) HK1175811A1 (zh)
MX (2) MX337982B (zh)
RU (1) RU2012117719A (zh)
WO (1) WO2011047300A1 (zh)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009117439A2 (en) 2008-03-17 2009-09-24 The Scripps Research Institute Combined chemical and genetic approaches for generation of induced pluripotent stem cells
WO2010077955A1 (en) 2008-12-17 2010-07-08 The Scripps Research Institute Generation and maintenance of stem cells
ES2638464T3 (es) 2009-10-16 2017-10-20 The Scripps Research Institute Inducción de células pluripotentes
CN102597221B (zh) * 2009-11-04 2015-03-11 细胞动力国际有限公司 使用化学品的游离重编程
CN102959076B (zh) 2010-03-31 2015-09-16 斯克里普斯研究所 重编程细胞
WO2011159726A2 (en) 2010-06-14 2011-12-22 The Scripps Research Institute Reprogramming of cells to a new fate
WO2012030854A2 (en) 2010-09-01 2012-03-08 Whitehead Institute For Biomedical Research Compositions and methods for modulating emt and uses thereof
KR102703637B1 (ko) 2010-12-22 2024-09-05 페이트 세러퓨틱스, 인코포레이티드 단세포 분류 및 iPSC의 증강된 재프로그래밍을 위한 세포 배양 플랫폼
AU2012350353B2 (en) * 2011-12-13 2018-01-04 Unisa Ventures Pty Ltd Method of producing multipotent stem cells
CN102604894B (zh) * 2012-02-29 2014-07-30 中国科学院广州生物医药与健康研究院 用于制备神经干细胞的培养基及其用途
US20150017134A1 (en) * 2012-03-01 2015-01-15 Whitehead Institute For Biomedical Research Emt-inducing transcription factors cooperate with sox9
JP6470044B2 (ja) * 2012-09-03 2019-02-13 国立大学法人九州大学 がんに対する免疫療法の有効性の予測方法
EP2900808B1 (en) 2012-09-28 2019-04-03 Scripps Health Methods of differentiating stem cells into chondrocytes
KR101786276B1 (ko) * 2012-10-12 2017-11-15 캐논 가부시끼가이샤 데이터를 스트리밍하기 위한 방법, 데이터를 제공하기 위한 방법, 데이터를 획득하기 위한 방법, 컴퓨터 판독 가능 저장 매체, 서버 장치, 및 클라이언트 장치
EP2912166B1 (en) * 2012-10-29 2019-05-01 Scripps Health Methods of producing pluripotent stem cells from chondrocytes
JPWO2014058080A1 (ja) * 2012-11-30 2016-09-05 国立研究開発法人理化学研究所 体細胞のリプログラミングを亢進させる方法、及び細胞作製キット
KR102263013B1 (ko) 2013-01-09 2021-06-10 인터내셔날 스템 셀 코포레이션 피부 재생을 촉진시키는 소분자
EP3114214B1 (en) 2014-03-04 2023-11-01 Fate Therapeutics, Inc. Improved reprogramming methods and cell culture platforms
CA2974381A1 (en) 2015-01-26 2016-08-04 Fate Therapeutics, Inc. Methods and compositions for inducing hematopoietic cell differentiation
AU2016211688A1 (en) 2015-01-26 2017-08-10 Fate Therapeutics, Inc. Cells with increased immuno-regulatory properties and methods for their use and manufacture
US10738280B2 (en) 2015-03-18 2020-08-11 Ono Pharmaceutical Co., Ltd. Method for producing naïve pluripotent stem cells
RU2018106515A (ru) 2015-07-21 2019-08-21 Зе Чилдрен'С Медикал Сентер Корпорейшн Pd-l1-экспрессирующие гемопоэтические стволовые клетки и применения
KR20180055918A (ko) 2015-10-16 2018-05-25 페이트 세러퓨틱스, 인코포레이티드 기저 상태 다능성의 유도 및 유지를 위한 플랫폼
EP3371301A4 (en) 2015-11-04 2019-06-26 Fate Therapeutics, Inc. METHOD AND COMPOSITIONS FOR INDUCING THE DIFFERENTIATION OF HEMATOPOIETIC CELLS
ES2953925T3 (es) 2015-11-04 2023-11-17 Fate Therapeutics Inc Ingeniería genómica de células pluripotentes
CA3010808A1 (en) 2016-01-08 2017-07-13 National Cancer Center Japan Method for producing hepatic stem/precursor cells from mature hepatic cells using low-molecular-weight compound
CN109890956A (zh) * 2016-10-28 2019-06-14 国立研究开发法人国立癌研究中心 人肝前体细胞的制备方法
KR102107602B1 (ko) * 2017-05-29 2020-05-08 한양대학교 산학협력단 인간 성체 간세포 리프로그래밍 배지 조성물
CN110832069B (zh) * 2017-05-31 2023-06-20 北昊干细胞与再生医学研究院有限公司 用于化学诱导的谱系重编程的方法
CN107326007B (zh) * 2017-08-07 2020-06-12 南开大学 利用巴豆酸激活Zscan4等二细胞期基因并延长端粒，提高化学诱导重编程效率的方法
WO2019060708A1 (en) 2017-09-22 2019-03-28 The Children's Medical Center Corporation TREATMENT OF TYPE 1 DIABETES AND AUTOIMMUNE DISEASES OR DISORDERS
CN108251377B (zh) * 2018-01-16 2021-08-27 内蒙古大学 利用携带Xist Tale抑制性转录因子R6的R6-MEF制备饲养层细胞的方法
CN111684063A (zh) 2018-01-31 2020-09-18 富士胶片株式会社 细胞的制造方法
EP3868870A4 (en) * 2018-10-15 2022-10-19 Evia Life Sciences Inc. METHOD OF GENERATING STEM/PROGENIOR CELLS USING SMALL MOLECULAR COMPOUNDS FROM CELLS DERIVED FROM AN ENDODERMAL TISSUE OR ORGAN
WO2020213725A1 (ja) * 2019-04-17 2020-10-22 学校法人慶應義塾 誘導多能性幹細胞の製造方法及びキット
WO2021167703A1 (en) 2020-02-19 2021-08-26 Nammi Therapeutics, Inc. Formulated and/or co-formulated liposome compositions containing tgfb antagonist prodrugs useful in the treatment of cancer and methods thereof
CN116348592A (zh) * 2020-10-02 2023-06-27 菲特治疗公司 诱导性多能干细胞的改善的重编程、维持和保存
EP4170018A1 (en) * 2021-10-20 2023-04-26 Roslin Technologies Limited Ipsc induction and progeny derivation
WO2023067090A1 (en) * 2021-10-20 2023-04-27 Roslin Technologies Limited Ipsc induction and progeny derivation
WO2024111626A1 (ja) * 2022-11-25 2024-05-30 カルナバイオサイエンス株式会社 新規チアゾール誘導体
CN115948325A (zh) * 2022-12-15 2023-04-11 武汉睿健医药科技有限公司 一种诱导间质细胞向上皮细胞转化及重编程的诱导剂

Family Cites Families (100)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4797368A (en) 1985-03-15 1989-01-10 The United States Of America As Represented By The Department Of Health And Human Services Adeno-associated virus as eukaryotic expression vector
US5139941A (en) 1985-10-31 1992-08-18 University Of Florida Research Foundation, Inc. AAV transduction vectors
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5384253A (en) 1990-12-28 1995-01-24 Dekalb Genetics Corporation Genetic transformation of maize cells by electroporation of cells pretreated with pectin degrading enzymes
AU2515992A (en) 1991-08-20 1993-03-16 Genpharm International, Inc. Gene targeting in animal cells using isogenic dna constructs
CA2117096C (en) 1991-09-06 1997-11-04 Masafumi Arita 4-amino(alkyl)cyclohexane-1-carboxamide compound and use thereof
US5702932A (en) 1992-07-20 1997-12-30 University Of Florida Microinjection methods to transform arthropods with exogenous DNA
WO1995003402A1 (en) * 1993-07-22 1995-02-02 Merck & Co., Inc. EXPRESSION OF HUMAN INTERLEUKIN-1β IN A TRANSGENIC ANIMAL
US5656610A (en) 1994-06-21 1997-08-12 University Of Southern California Producing a protein in a mammal by injection of a DNA-sequence into the tongue
US5736524A (en) 1994-11-14 1998-04-07 Merck & Co.,. Inc. Polynucleotide tuberculosis vaccine
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US6013516A (en) 1995-10-06 2000-01-11 The Salk Institute For Biological Studies Vector and method of use for nucleic acid delivery to non-dividing cells
US5780448A (en) 1995-11-07 1998-07-14 Ottawa Civic Hospital Loeb Research DNA-based vaccination of fish
US20030059913A1 (en) 1995-11-20 2003-03-27 Walter Weyler Novel Microorganisms with ability to degrade indole and novel enzymes therefrom
GB9807935D0 (en) 1998-04-14 1998-06-10 Univ Edinburgh Lineage specific cells and progenitor cells
US5945100A (en) 1996-07-31 1999-08-31 Fbp Corporation Tumor delivery vehicles
DE69737631T3 (de) 1996-08-12 2011-08-18 Mitsubishi Tanabe Pharma Corp. MEDIKAMENTE ENTHALTEND Rho-KINASE INHIBITOREN
US5981274A (en) 1996-09-18 1999-11-09 Tyrrell; D. Lorne J. Recombinant hepatitis virus vectors
ATE394484T1 (de) 1997-06-13 2008-05-15 Ludwig Inst Cancer Res Smad 6 und dessen anwendungen
US5994624A (en) 1997-10-20 1999-11-30 Cotton Incorporated In planta method for the production of transgenic plants
US5994136A (en) 1997-12-12 1999-11-30 Cell Genesys, Inc. Method and means for producing high titer, safe, recombinant lentivirus vectors
US20060263382A1 (en) 1998-06-20 2006-11-23 Richard Hotchkiss Membrane-permeant peptide complexes for treatment of sepsis
JP2002521025A (ja) 1998-07-24 2002-07-16 ザ カーネギー インスチチューション オブ ワシントン 増殖因子のＴＧＦ−βファミリーのメンバーを使用する、生殖系列幹細胞の維持および増殖のための方法。
WO2000078351A1 (fr) 1999-06-18 2000-12-28 Mitsubishi Pharma Corporation Promoteurs de l'osteogenese
US6730293B1 (en) 1999-08-24 2004-05-04 Cellgate, Inc. Compositions and methods for treating inflammatory diseases of the skin
AU6865100A (en) 1999-09-02 2001-04-10 Mitsubishi Pharma Corporation Osteogenesis promoting agents
US20020142457A1 (en) 1999-12-28 2002-10-03 Akihiro Umezawa Cell having the potentiality of differentiation into cardiomyocytes
JP2002184539A (ja) 2000-12-14 2002-06-28 Auto Network Gijutsu Kenkyusho:Kk コネクタ
WO2008108741A1 (en) 2007-03-07 2008-09-12 S*Bio Pte Ltd Combination of benzimidazole anti-cancer agent and a second anti-cancer agent
US20030125344A1 (en) 2001-03-23 2003-07-03 Bayer Corporation Rho-kinase inhibitors
US20030087919A1 (en) 2001-03-23 2003-05-08 Bayer Corporation Rho-kinase inhibitors
JP2003097552A (ja) 2001-09-21 2003-04-03 Nsk Ltd 摩擦付加装置および直動案内装置
US20030062225A1 (en) 2001-10-03 2003-04-03 Stucky Paul A. Elevator load bearing assembly having a detectable element that is indicative of local strain
KR101072867B1 (ko) 2001-10-31 2011-10-17 유니버시티 오브 노스 텍사스 헬스 사이언스 센터 뼈 형태발생 단백질(ｂｍｐ), ｂｍｐ 수용체 및 ｂｍｐ 결합 단백질 및 녹내장 진단 및 치료에서 그의 용도
PT1456380E (pt) 2001-11-02 2012-07-23 Giuliani Int Ltd Inibidores smad7 para o tratamento de doenças do snc
AU2003202263A1 (en) 2002-01-10 2003-07-30 Bayer Healthcare Ag Roh-kinase inhibitors
JP4469179B2 (ja) 2002-01-23 2010-05-26 バイエル ファーマセチカル コーポレーション Ｒｈｏキナーゼ阻害剤としてのピリミジン誘導体
CA2473910C (en) 2002-01-23 2011-03-15 Bayer Pharmaceuticals Corporation Pyrimidine derivatives as rho-kinase inhibitors
US20050182040A1 (en) 2002-04-03 2005-08-18 Naonori Imazaki Benzamide derivatives
GB0210539D0 (en) 2002-05-08 2002-06-19 Univ Edinburgh Control of es cell self renewal and lineage specification, and medium therefor
US20040039796A1 (en) 2002-08-08 2004-02-26 Virtual Radio, Inc. Personalized cyber disk jockey and Internet radio advertising
CA2503646C (en) 2002-10-28 2011-09-27 Bayer Healthcare Ag Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors
CA2515215A1 (en) * 2003-02-10 2004-08-26 Amgen Inc. Vanilloid receptor ligands and their use in treatments
AU2003901099A0 (en) 2003-03-11 2003-03-27 Es Cell International Pte Ltd. Methods of inducing differentiation of stem cells
US20070010008A1 (en) 2005-06-29 2007-01-11 Tissuetech, Inc. Ex vivo expansion of primary animal cells
AU2004316996A1 (en) 2003-06-20 2005-09-15 The Regents Of The University Of California Polypeptide transduction and fusogenic peptides
CN1863904B (zh) 2003-10-03 2014-05-28 福田惠一 由干细胞分化诱导心肌细胞的方法
ES2426288T3 (es) 2003-10-15 2013-10-22 Ube Industries, Ltd. Novedoso derivado de imidazol
AU2004281309A1 (en) 2003-10-16 2005-04-28 The University Court Of The University Of Edinburgh Control of ES cell self-renewal and lineage specification, and medium therefor
WO2005049812A1 (en) 2003-11-19 2005-06-02 Australian Stem Cell Centre Limited Methods for producing blood products from pluripotent cells in cell culture
US20070269412A1 (en) 2003-12-02 2007-11-22 Celavie Biosciences, Llc Pluripotent cells
JP2007519754A (ja) 2004-01-30 2007-07-19 スミスクライン ビーチャム コーポレーション 化合物
JP2008501640A (ja) 2004-04-21 2008-01-24 ザ ユニヴァーシティー オヴ シカゴ ミオシン軽鎖キナーゼ阻害剤及びその使用
US20060024634A1 (en) 2004-07-28 2006-02-02 3M Innovative Properties Company Self-ligating orthodontic appliance with clip
US8187878B2 (en) 2004-08-13 2012-05-29 University Of Georgia Research Foundation, Inc. Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
US20080268533A1 (en) 2004-08-25 2008-10-30 University Of Georgia Research Foundation, Inc. Methods and Compositions Utilizing Myc and Gsk3Beta to Manipulate the Pluripotency of Embryonic Stem Cells
US20060182724A1 (en) 2005-02-15 2006-08-17 Riordan Neil H Method for expansion of stem cells
CA2617611A1 (en) 2005-08-01 2007-02-08 Nupotential, Llc Production of reprogrammed cells with restored potential
US20080242594A1 (en) 2005-09-08 2008-10-02 Mckay Ronald D G Methods for Promoting Stem Cell Proliferation and Survival
GB0523039D0 (en) * 2005-11-11 2005-12-21 Univ Edinburgh Reprogramming and genetic modification of cells
US20090227032A1 (en) 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US8048999B2 (en) 2005-12-13 2011-11-01 Kyoto University Nuclear reprogramming factor
WO2007088651A1 (ja) 2006-02-01 2007-08-09 The University Of Tokyo ＴＧＦ－βシグナル阻害剤と抗腫瘍剤の組み合せ使用
US7541186B2 (en) 2006-02-22 2009-06-02 University Of Washington Method of generating human retinal progenitors from embryonic stem cells
GB2436737B (en) 2006-03-30 2008-07-09 Univ Edinburgh Culture medium containing kinase inhibitors,and uses thereof
GB0615327D0 (en) 2006-03-30 2006-09-13 Univ Edinburgh Culture medium containing kinase inhibitors and uses thereof
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
SE534150C2 (sv) 2006-05-02 2011-05-10 Wisconsin Alumni Res Found Förfarande för differentiering av stamceller till celler av den endodermala och pankreatiska utvecklingslinjen
EP2035416A1 (en) 2006-06-30 2009-03-18 Schering Corporation Substituted piperidines that increase p53 activity and the uses thereof
AU2007271964B2 (en) 2006-07-14 2012-01-19 Novartis Ag Pyrimidine derivatives as ALK-5 inhibitors
JP2008099662A (ja) * 2006-09-22 2008-05-01 Institute Of Physical & Chemical Research 幹細胞の培養方法
GB0622395D0 (en) 2006-11-09 2006-12-20 Univ Cambridge Tech Methods relating to pluripotent cells
JP5419279B2 (ja) * 2007-01-17 2014-02-19 ウィスコンシン アラムニ リサーチ ファンデーション 改良された幹細胞の培養
US20100172883A1 (en) 2007-01-19 2010-07-08 Bruneau Benoit Gaetan Methods of generating cardiomyocytes
EP2126045A4 (en) 2007-01-30 2010-05-26 Univ Georgia EARLY MESODERM CELLS, STABLE POPULATION OF MESENDODERM CELLS WITH THE ABILITY TO GENERATE ENDODERM AND MESODERM CELL LINES AND MULTIPOTENTIAL MIGRATION CELLS
WO2008105630A1 (en) 2007-02-27 2008-09-04 Procell Therapeutics Inc. Combined use of cell permeable nanog and oct4 for increasing self-renewal and suppressing differentiation of stem cells
WO2008126932A2 (en) 2007-04-09 2008-10-23 Riken Epigenetical regulation of brain plasticity
US8648069B2 (en) 2007-06-08 2014-02-11 Abbvie Inc. 5-substituted indazoles as kinase inhibitors
JP2008307007A (ja) 2007-06-15 2008-12-25 Bayer Schering Pharma Ag 出生後のヒト組織由来未分化幹細胞から誘導したヒト多能性幹細胞
CA2691793A1 (en) * 2007-06-29 2009-01-08 Cellular Dynamics International, Inc. Automated method and apparatus for embryonic stem cell culture
WO2009032456A2 (en) 2007-08-01 2009-03-12 Primegen Biotech Llc Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state
RU2492232C2 (ru) 2007-08-31 2013-09-10 Уайтхэд Инститьют Фор Байомедикал Рисерч СТИМУЛЯЦИЯ ПУТИ Wnt ПРИ ПЕРЕПРОГРАММИРОВАНИИ СОМАТИЧЕСКИХ КЛЕТОК
CA2660123C (en) 2007-10-31 2017-05-09 Kyoto University Nuclear reprogramming method
US20110151447A1 (en) 2007-11-06 2011-06-23 Children's Medical Center Corporation Method to produce induced pluripotent stem (ips) cells from non-embryonic human cells
JP4604076B2 (ja) 2007-11-07 2010-12-22 国立大学法人静岡大学 燃料電池用電解質膜
WO2009073523A2 (en) 2007-11-29 2009-06-11 Children's Hospital Of Orange County De-differentiation of human cells
US20110190729A1 (en) 2007-11-30 2011-08-04 Cytomatrix Pty Ltd Methods of inducing pluripotency involving sox2 protein
WO2009067757A1 (en) 2007-11-30 2009-06-04 Cytomatrix Pty Ltd Methods of inducing pluripotency involving oct4 protein
JP2009215191A (ja) * 2008-03-07 2009-09-24 Keio Gijuku 神経損傷治療剤及び神経損傷治療方法
WO2009117439A2 (en) 2008-03-17 2009-09-24 The Scripps Research Institute Combined chemical and genetic approaches for generation of induced pluripotent stem cells
US8298825B1 (en) * 2008-08-25 2012-10-30 The General Hospital Corporation TGF-beta receptor inhibitors to enhance direct reprogramming
EP2370445B1 (en) 2008-12-03 2014-07-23 The Scripps Research Institute Stem cell cultures
WO2010077955A1 (en) 2008-12-17 2010-07-08 The Scripps Research Institute Generation and maintenance of stem cells
WO2010102267A2 (en) 2009-03-06 2010-09-10 Ipierian, Inc. Tgf-beta pathway inhibitors for enhancement of cellular reprogramming of human cells
WO2010137348A1 (en) * 2009-05-29 2010-12-02 Keio University Method for selecting clone of induced pluripotent stem cells
JP5376478B2 (ja) * 2009-08-07 2013-12-25 国立大学法人京都大学 効率的な人工多能性幹細胞の樹立方法
ES2638464T3 (es) * 2009-10-16 2017-10-20 The Scripps Research Institute Inducción de células pluripotentes
WO2011109695A1 (en) 2010-03-05 2011-09-09 Texas Heart Institute Ets2 and mesp1 generate cardiac progenitors from fibroblasts
CN102959076B (zh) 2010-03-31 2015-09-16 斯克里普斯研究所 重编程细胞
US9905105B1 (en) 2016-12-01 2018-02-27 General Electric Company Method of increasing sensing device noticeability upon low battery level

Also Published As

Publication number Publication date
AU2010306627B2 (en) 2014-07-17
US20150240214A1 (en) 2015-08-27
JP2016027808A (ja) 2016-02-25
JP2024138390A (ja) 2024-10-08
JP2013507932A (ja) 2013-03-07
US20180163181A1 (en) 2018-06-14
RU2012117719A (ru) 2013-11-27
CN105861446A (zh) 2016-08-17
EP3235901B1 (en) 2022-12-21
JP2019110912A (ja) 2019-07-11
US20120264218A1 (en) 2012-10-18
MX337982B (es) 2016-03-30
CA3091210C (en) 2023-04-04
EP2488630A1 (en) 2012-08-22
ES2638464T3 (es) 2017-10-20
EP2488630B1 (en) 2017-07-05
JP5808331B2 (ja) 2015-11-10
MX2012004283A (es) 2012-06-28
CN105861446B (zh) 2021-10-01
BR112012008848A2 (pt) 2019-09-24
JP2020167994A (ja) 2020-10-15
CA2777720C (en) 2020-10-06
JP6683857B2 (ja) 2020-04-22
JP2022185128A (ja) 2022-12-13
CA3194845A1 (en) 2011-04-21
JP6491284B2 (ja) 2019-03-27
EP3235901A1 (en) 2017-10-25
AU2010306627A1 (en) 2012-05-17
JP6189384B2 (ja) 2017-08-30
EP4206319A1 (en) 2023-07-05
CA3091210A1 (en) 2011-04-21
MX2021014919A (es) 2022-07-21
WO2011047300A1 (en) 2011-04-21
US9909105B2 (en) 2018-03-06
CN113621576A (zh) 2021-11-09
US11046933B2 (en) 2021-06-29
CN102741394B (zh) 2016-05-04
JP7160855B2 (ja) 2022-10-25
JP2017192401A (ja) 2017-10-26
ES2938049T3 (es) 2023-04-04
US20210403878A1 (en) 2021-12-30
CA2777720A1 (en) 2011-04-21
US9005968B2 (en) 2015-04-14
CN102741394A (zh) 2012-10-17
EP2488630A4 (en) 2013-06-26
JP7520083B2 (ja) 2024-07-22

Similar Documents

Publication Publication Date Title
HK1175811A1 (zh) 多能細胞的誘導
IL267629A (en) A method for eukaryotic cell culture
IL214818A0 (en) Differentiation of pluripotent cells
ZA201008392B (en) Treatment of pluripotent cells
HK1186492A1 (zh) 多能幹細胞的分化
SG10201500674YA (en) Pluripotent stem cells
EP2414510A4 (en) INDUCED PLURIPOTENT STEM CELLS
HK1252414A1 (zh) 重新設定的多能幹細胞的製備
EP2475761A4 (en) PHOTO BIOREACTOR
EP2438246A4 (en) CONSTRUCTION ASPECTS
GB0905611D0 (en) Bioreactor
EP2516615A4 (en) IMPROVED BIOREACTORS
EP2601279A4 (en) SUPERTORREFICATION FROM BIOMASS TO BIO COAL
IL217609A (en) A bioreactor containing silicone materials
TWM372743U (en) Improved structure of Kendama
TWM365675U (en) Improved structure of teapoy
GB0919773D0 (en) Induced pluripotent stem cell
GB0904173D0 (en) Way of extracting energy
GB0921526D0 (en) Bioreactor
TWM374127U (en) Structure of three-string Huqin
GB0905280D0 (en) Novel uses of VEGFxxxb
GB0906303D0 (en) Culture
GB0906302D0 (en) Culture
GB0906304D0 (en) Culture
GB0906307D0 (en) Culture